Compounds > hydralazine

hydralazine and phenobarbital

hydralazine has been researched along with phenobarbital in 17 studies

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (47.06)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (35.29)	29.6817
2010's	3 (17.65)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Freeman, RW; Harbison, RD; Oates, JA; Woosley, RL	1
Colby, HD; Dalal, NS; LaCagnin, LB; O'Donnell, JP	1
Abdella, TN; Anderson, GD; Brooks, TF; Sibai, BM; Spinnato, JA; Taslimi, M	1
Haller, J	1
Zahn, K	1
Ahuja, GK; Schumacher, GA	1
Iwaki, M; Ogiso, T; Ohtsuki, N	1
Iwaki, M; Matsuoka, H; Ogiso, T	1

Reviews

1 review(s) available for hydralazine and phenobarbital

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

16 other study(ies) available for hydralazine and phenobarbital

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Evidence for the biotransformation of procainamide to a reactive metabolite. Toxicology and applied pharmacology, 1979, Volume: 50, Issue:1 Topics: Acetylation; Animals; Biotransformation; Hydralazine; Male; Mice; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Procainamide; Salmonella typhimurium	1979
Metabolic activation of hydralazine by rat liver microsomes. Biochemical pharmacology, 1987, Aug-15, Volume: 36, Issue:16 Topics: Animals; Biotransformation; Electron Spin Resonance Spectroscopy; Hydralazine; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains	1987
Maternal and perinatal outcome of conservative management of severe preeclampsia in midtrimester. American journal of obstetrics and gynecology, 1985, May-01, Volume: 152, Issue:1 Topics: Administration, Oral; Antihypertensive Agents; Bed Rest; Birth Weight; Delivery, Obstetric; Diuretics; Female; Fetal Death; Gestational Age; Humans; Hydralazine; Infant, Newborn; Magnesium Sulfate; Methyldopa; Outcome and Process Assessment, Health Care; Phenobarbital; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Pregnancy, Prolonged; Retrospective Studies	1985
[Therapy of EPH gestosis]. Deutsche medizinische Wochenschrift (1946), 1973, Jul-06, Volume: 98, Issue:27 Topics: Chlorthalidone; Diazepam; Diet Therapy; Eclampsia; Edema; Female; Furosemide; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Magnesium Sulfate; Mannitol; Phenobarbital; Phytotherapy; Plants, Medicinal; Pre-Eclampsia; Pregnancy; Proteinuria; Rauwolfia	1973
The effects of vasoactive drugs on the retinal circulation. Transactions of the ophthalmological societies of the United Kingdom, 1966, Volume: 86 Topics: Bis-Trimethylammonium Compounds; Bromides; Ergoloid Mesylates; Heparin; Hydralazine; Hypertension; Neostigmine; Nicotinic Acids; Nitroglycerin; Papaverine; Phenobarbital; Phentolamine; Phytotherapy; Plants, Medicinal; Plants, Toxic; Procaine; Protoveratrines; Regional Blood Flow; Reserpine; Retinal Vessels; Scotoma; Tolazoline; Vasodilator Agents; Veratrum	1966
Drug-induced systemic lupus erythematosus. Primidone as a possible cause. JAMA, 1966, Nov-07, Volume: 198, Issue:6 Topics: Electroencephalography; Epilepsy; Female; Humans; Hydralazine; Hydroxychloroquine; Lupus Erythematosus, Systemic; Middle Aged; Phenobarbital; Phenytoin; Primidone	1966
Hydralazine-phenobarbital interactions in rats. II. Disposition of hydralazine and its acid-labile conjugates, and liver drug-metabolizing enzyme activities in normotensive and spontaneously hypertensive rats. Chemical & pharmaceutical bulletin, 1983, Volume: 31, Issue:1 Topics: Animals; Drug Interactions; Hydralazine; Hypertension; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1983
Pharmacodynamic interaction between hydralazine and phenobarbital in normotensive and spontaneously hypertensive rats. Chemical & pharmaceutical bulletin, 1982, Volume: 30, Issue:10 Topics: Animals; Drug Interactions; Hydralazine; Hypertension; Male; Phenobarbital; Rats; Rats, Inbred Strains	1982