hydralazine has been researched along with nifedipine in 153 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 76 (49.67) | 18.7374 |
| 1990's | 37 (24.18) | 18.2507 |
| 2000's | 15 (9.80) | 29.6817 |
| 2010's | 18 (11.76) | 24.3611 |
| 2020's | 7 (4.58) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, JM; Fake, CS; Hamilton, TC; Poyser, RH; Watts, EA | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Andersson, KE; Mikkelsen, E; Pedersen, OL | 1 |
| Hiwatari, M; Satoh, K; Taira, N | 1 |
| Duggan, PM; McCowan, LM; Stewart, AW | 1 |
| Battaglia, M; Daniel, W; Pavone, F; Sansone, M; Vetulani, J | 1 |
| Battaglia, M; Pavone, F; Sansone, M | 2 |
| Greene, ER; Hackett, PH; Hartig, GS; Levine, BD; Roach, RC | 1 |
| Maev, IV; Vorob'ev, LP | 1 |
| Bardán, B; Calleja, JM; Gil-Longo, J; Orallo, F | 1 |
| Bunchman, TE; Lynch, RE; Wood, EG | 1 |
| Villarreal Ordaz, F; Walss Rodríguez, RJ | 1 |
| Bassett, AH; el Nahas, AM; Hutchesson, A; Thurrell, W; Wight, JP | 1 |
| Burns, RJ; Frankel, D; Leenen, FH; Myers, MG | 1 |
| Appelman, Z; Fenakel, G; Fenakel, K; Katz, Z; Lurie, S; Shoham, Z | 1 |
| Buskila, D; Hercz, G; Langevitz, P; Lee, P | 1 |
| Kastanaian, AA; Masalitinova, IV; Vorob'ev, BI; Zhilin, SV | 1 |
| Strauer, BE | 1 |
| Rahimtoola, SH | 1 |
| Akashi, A; Ashida, S; Tanaka, S | 1 |
| Inariba, H; Inoue, T; Itoh, S; Kanayama, Y; Takaori, K; Takeda, T | 1 |
| Gueron, M; Sofer, S | 1 |
| Ogihara, M; Sunaga, K | 1 |
| Brogden, RN; Clissold, SP; Sorkin, EM | 1 |
| Pedrinelli, R; Tarazi, RC | 2 |
| Ioannou, P; Talesnik, J | 1 |
| Nara, Y; Note, S; Sato, T; Yamori, Y | 1 |
| Catalano, M; Contiello, V; Mazza, F; Morra, AM; Morra, MG; Polcino, A | 1 |
| Imamura, N; Kurokawa, K; Nakajima, S; Ueda, M | 1 |
| DeFeo, TT; Morgan, KG | 1 |
| Adams, GE; Godden, J; Howells, N; Stratford, IJ | 1 |
| Crawford, MH; O'Rourke, RA; Vittitoe, JA; Wilson, RS | 1 |
| Ogihara, M | 1 |
| Littler, WA; Smith, SA | 1 |
| Naden, RP; Redman, CW | 1 |
| Murphy, MB | 1 |
| Burns, R; Frankel, D; Leenen, FH; Myers, MG | 1 |
| Elkayam, U; Freidenberger, L; Hsueh, W; Rahimtoola, SH; Roth, A; Weber, L | 1 |
| Kamei, C; Kurokawa, K; Tasaka, K | 1 |
| Imai, S; Matsui, K; Ogawa, Y | 1 |
| Artman, M; Graham, TP | 1 |
| Karasawa, A; Kubo, K; Nakamizo, N; Oka, T; Shuto, K | 2 |
| Baker, JR; Haigh, RJ; Warburton, G; Weston, AH; Williamson, IH | 1 |
| Chun, DS; Corriveau, ML; Dolan, GF; Keller, CA; Rosen, BJ | 1 |
| Bingham, WT; Duncan, WJ; Kasian, GF; Mersal, A; Ninan, A; Sankaran, K; Tyrrell, MJ | 1 |
| Goldberg, HS; Halpern, SM; Jasper, AC; Koerner, SK; Lehrman, S; Shah, PK | 1 |
| Nakajima, S; Ueda, M | 1 |
| Parnell, L; Ramsay, LE; Waller, PC | 1 |
| Kato, H; Takata, Y | 1 |
| Nagao, T; Nakajima, H; Narita, H; Yamaguchi, I | 1 |
| Schroeder, JS | 1 |
| Siegl, PK; Wenger, HC | 1 |
| Ogilvie, RI | 1 |
| Hannan, WJ; Muir, AL; Wathen, CG | 1 |
| D'Alonzo, GE; Dantzker, DR; Levy, PS; Rich, S | 1 |
| DiBona, GF | 1 |
| Nordlander, M | 1 |
| Ruksin, VV | 1 |
| Dozor, AJ; Fyler, DC; Geggel, RL; Reid, LM | 1 |
| Brundage, BH; Levy, PS; Rich, S | 1 |
| Gladman, DD; Sternberg, L | 1 |
| Fowler, A; Glauser, F; Ohar, J; Polatty, C; Robichaud, A; Vetrovec, G | 1 |
| Matsuda, S; Ueda, M | 1 |
| Deedwania, PC; Fagan, TC; Mehta, JL; Sternleib, C; Vlachakis, N | 1 |
| de Jonge, A; Jonkman, FA; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B | 1 |
| Marxer, A; Schier, O | 1 |
| Awasthi, KK; Srivastava, KC | 1 |
| Brooks, HL; Gross, GJ; Warltier, DC; Zyvoloski, MG | 2 |
| Hiramatsu, K; Kubota, T; Yamada, T; Yamagishi, F | 1 |
| Rubin, LJ | 1 |
| Lipe, S; Moulds, RF | 1 |
| Ram, CV | 1 |
| Borer, JS; Fisher, J; Goldberg, HL; Mermelstein, M; Moses, JW; Niarchos, AP; Whitman, HH | 1 |
| Garthoff, B; Knorr, A | 1 |
| Aguila, E; Baz, R; Lopez, LM; Mehta, JL | 1 |
| Bulpitt, CJ; Dollery, CT; Murphy, MB | 1 |
| Medina, N; Packer, M; Yushak, M | 1 |
| Campese, VM; Elkayam, U; Massry, SG; Rahimtoola, SH; Weber, L | 1 |
| Ganz, R; Levy, PS; Rich, S | 1 |
| Elkayam, U; McKay, CR; Rahimtoola, SH; Weber, L | 1 |
| McMurtry, IF; Morris, KG; Stanbrook, HS | 1 |
| Acconcia, MC; Gaspardone, A; Pannarale, G; Valente, A | 1 |
| Douglas, JS | 1 |
| Zsotér, TT | 1 |
| Brown, MJ; Causon, R; Dollery, CT; Murphy, MB; Scriven, AJ | 1 |
| Knorr, A; Stoepel, K | 1 |
| Fujie, K; Kubo, T; Misu, Y; Yamashita, M | 1 |
| Ito, T; Ito, Y; Matsumoto, S; Okabe, F; Sada, T; Sato, M; Sekine, I; Su, KM; Takahashi, M; Ueda, A | 1 |
| Ishii, H; Itoh, K; Nose, T | 1 |
| Doering, PL; Hatton, RC; Levin, AC | 1 |
| Schömig, A; Schön, HR | 1 |
| Kawashima, A; Koike, H; Nishio, S; Ueno, Y | 1 |
| Shteĭngart, IuN; Volkova, LI | 1 |
| Albers, N; Beier, C; Bohnhorst, B; Bökenkamp, A; Brodehl, J; Offner, G | 1 |
| Bevan, EG; Carmichael, HA; Findlay, JG; Herrick, AL; Lorimer, AR; Murray, GD; Pringle, SD; Reid, JL; Waller, PC; Weir, RJ | 1 |
| Flores Padilla, LM; Walss Rodriguez, RJ | 1 |
| Jegasothy, R; Paranthaman, S | 1 |
| Filep, JG; Földes-Filep, E; Fournier, A; Skrobik, Y | 1 |
| Nasu, T; Yanagimoto, S | 1 |
| Liu, X; Songu-Mize, E | 1 |
| Atkinson, J; Duvivier, C; Lartaud-Idjouadiene, I; Marque, V; Niederhoffer, N; Peslin, R | 1 |
| Catanese, VM; Donohue, TJ; Dworkin, LD; Lango, MN; Ma, J | 1 |
| Ghosh, TS; Kwawukume, EY | 1 |
| Taguchi, T; Takenaka, T; Takeo, S; Uchida, W | 1 |
| Dam, TV; deBlois, D; Hamet, P; Moreau, P; Tea, BS | 1 |
| Borbolla, JR; Collados, MT; López, S; Massó, FA; Montaño, LF; Páez, A; Sandoval, J | 1 |
| Barhum, Y; Belkin, V; Kaganovsky, E; Kessler-Icekson, G; Schaper, J; Schaper, W | 1 |
| Hussein, M; Mooij, JM; Roujouleh, H | 1 |
| Aali, BS; Nejad, SS | 1 |
| Adams, MA; Bushfield, TL; Hale, TM; Woolard, J | 1 |
| Dennedy, MC; Houlihan, DD; Morrison, JJ; Ravikumar, N | 1 |
| Heazell, AE; Mahomoud, S; Pirie, AM | 1 |
| Adams, MA; Hale, TM; Hannan, JL; Heaton, JP; Smallegange, C | 1 |
| Chiou, SY; Lai, GW; Lin, G; Lin, LY | 1 |
| An, SJ; Choi, JH; Choi, KD; Kim, HJ; Kim, JS; Lee, JE | 1 |
| Hayashi, K; Ishiguro, K; Itoh, H; Sakamaki, Y; Sasamura, H | 1 |
| Baldwin, K; McCoy, S | 1 |
| Esmaeili, S; Khazaeipour, Z; Motevalian, M; Pourmojieb, M; Rezaei, Z; Sharbaf, FR; Youefzadeh-Fard, Y | 1 |
| Gong, SP; Huang, LP; Liu, QQ; Yu, YH | 1 |
| Alexander, JM; Wilson, KL | 1 |
| Arulkumaran, N; Lightstone, L | 1 |
| Firoz, T; Gordon, R; MacDonell, K; Magee, LA; Payne, BA; Vidler, M; von Dadelszen, P | 1 |
| Simon, M; Vadhera, RB | 1 |
| Dorrance, AM; Jackson, WF; Pires, PW | 1 |
| Olson-Chen, C; Seligman, NS | 1 |
| Abreo, A; Greene, N; Kilpatrick, SJ; Main, EK; Melsop, K; Peterson, N; Shields, LE | 1 |
| Demir, B; Engin, MS; Keleş, MK; Küçüker, İ; Yosma, E | 1 |
| Kilpatrick, SJ; Sharma, KJ | 1 |
| Gupta, A; Sharma, C; Soni, A; Verma, A; Verma, S | 1 |
| Broscious, R; Devabhakthuni, S; Noel, ZR; Watson, K | 1 |
| Sequeira, RP; Sridharan, K | 1 |
| Akerman, MB; Elsayad, A; Halpern, TA; Heiselman, CJ; Heo, HJ; Kantorowska, A; Muscat, JC; Sicuranza, GB; Vintzileos, AM | 1 |
| Cheng, Y; Jiang, YF; Li, JB; Wu, HZ; Yu, D; Zhu, ZN | 1 |
| Greene, NH; Kilpatrick, SJ; Pon, FF | 1 |
| Shigemi, D; Taguchi, R; Yasunaga, H | 1 |
| Hoffman, MC; Wautlet, CK | 1 |
| Hamidy, Y; Novri, DA; S, D; Savira, M | 1 |
| Bhat, AD; Dombrowski, MM; Keasler, PM; Kolluru, L; Palanisamy, A; Singh, PM | 1 |
26 review(s) available for hydralazine and nifedipine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Vasodilator therapy in chronic severe aortic regurgitation.
Topics: Aortic Valve Insufficiency; Chronic Disease; Digitalis Glycosides; Echocardiography; Hemodynamics; Humans; Hydralazine; Nifedipine; Vasodilator Agents | 1990 |
Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.
Topics: Absorption; Adrenergic beta-Antagonists; Angina Pectoris; Animals; Blood Platelets; Calcium Channel Blockers; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Circulation; Drug Interactions; Heart Conduction System; Heart Failure; Hemodynamics; Histamine Release; Humans; Hydralazine; Hypertension; Kidney; Kinetics; Myocardial Infarction; Nifedipine; Oxygen Consumption; Physical Exertion | 1985 |
Antihypertensive agents--the race for third place.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Captopril; Diazoxide; Felodipine; Humans; Hydralazine; Indoramin; Labetalol; Minoxidil; Nicardipine; Nifedipine; Vasodilator Agents; Verapamil | 1985 |
Antihypertensive drugs in pregnancy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Female; Fetus; Humans; Hydralazine; Hypertension; Labetalol; Methyldopa; Nifedipine; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Regional Blood Flow; Uterus | 1985 |
Combination therapy with isosorbide dinitrate: current status and the future.
Topics: Angina Pectoris; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Esophageal Achalasia; Exercise Test; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Nifedipine; Nitroprusside; Propranolol; Verapamil | 1985 |
Antihypertensive agents 1969-1980.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Ergolines; Fusaric Acid; Guanidines; Humans; Hydralazine; Indoramin; Methyldopa; Minoxidil; Nifedipine; Piperazines; Prazosin; Prostaglandins | 1981 |
Cardiovascular effects of vasodilator therapy for pulmonary arterial hypertension.
Topics: Cardiac Output; Echocardiography; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Hypotension; Hypoxia; Myocardial Contraction; Nifedipine; Pulmonary Circulation; Stroke Volume; Time Factors; Vascular Resistance; Vasodilator Agents | 1983 |
Calcium, drug action and hypertension.
Topics: Animals; Arteries; Calcium; Chelating Agents; Humans; Hydralazine; Hypertension; Lanthanum; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Veins; Verapamil | 1983 |
Hypertensive crisis.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Diazoxide; Eclampsia; Emergencies; Female; Humans; Hydralazine; Hypertension; Hypertension, Malignant; Labetalol; Minoxidil; Nifedipine; Nitroprusside; Phentolamine; Prazosin; Pregnancy; Pulmonary Edema; Trimethaphan | 1984 |
[Early pulmonary hypertension: current therapeutic prospectives].
Topics: Calcium Channel Blockers; Captopril; Diazoxide; Diltiazem; Humans; Hydralazine; Hypertension, Pulmonary; Isoproterenol; Nifedipine; Phentolamine; Time Factors | 1982 |
Calcium antagonists.
Topics: Action Potentials; Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Bronchial Spasm; Calcium; Diazoxide; Diltiazem; Hemodynamics; Humans; Hydralazine; Lanthanum; Muscle, Smooth; Myocardial Contraction; Nifedipine; Nitrites; Nitroprusside; Papillary Muscles; Verapamil | 1980 |
Use of nifedipine in the hypertensive diseases of pregnancy.
Topics: Female; Humans; Hydralazine; Hypertension; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Risk Factors; Time Factors | 1994 |
Pharmacotherapeutic options for the treatment of preeclampsia.
Topics: Female; Humans; Hydralazine; Magnesium Sulfate; Nicardipine; Nifedipine; Nitroprusside; Pre-Eclampsia; Pregnancy; Risk Factors | 2009 |
[Clinical efficacy and perinatal outcome of nifedipine for severe preeclampsia: meta-analysis].
Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Infant, Newborn; Labetalol; Nifedipine; Perinatal Mortality; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Respiratory Distress Syndrome, Newborn; Severity of Illness Index | 2012 |
Hypertensive emergencies of pregnancy.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Creatine; Diuretics; Emergency Medicine; Female; Fetal Monitoring; Humans; Hydralazine; Infusions, Intravenous; Labetalol; Methyldopa; Nifedipine; Nitroprusside; North America; Oliguria; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Proteinuria | 2013 |
Severe pre-eclampsia and hypertensive crises.
Topics: Administration, Intravenous; Administration, Oral; Antihypertensive Agents; Critical Care; Early Diagnosis; Eclampsia; Female; HELLP Syndrome; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Labetalol; Magnesium Sulfate; Methyldopa; Nifedipine; Nitroglycerin; Pre-Eclampsia; Pregnancy; Risk Assessment; Risk Factors; Severity of Illness Index; Treatment Outcome; United Kingdom | 2013 |
Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review.
Topics: Administration, Oral; Antihypertensive Agents; Female; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Labetalol; Methyldopa; Nifedipine; Postpartum Period; Pregnancy; Pregnancy Complications, Cardiovascular; Randomized Controlled Trials as Topic; Treatment Outcome; Vasodilator Agents | 2014 |
Hypertensive emergencies in pregnancy.
Topics: Antihypertensive Agents; Eclampsia; Emergencies; Female; Humans; Hydralazine; Hypertension; Hypertension, Pregnancy-Induced; Labetalol; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Severity of Illness Index | 2014 |
Hypertensive Emergencies in Pregnancy.
Topics: Antihypertensive Agents; Cesarean Section; Chronic Disease; Congenital Abnormalities; Emergencies; Esophageal Atresia; Female; Heart Defects, Congenital; Humans; Hydralazine; Hypertension; Hypertension, Pregnancy-Induced; Hypospadias; Labetalol; Labor, Induced; Male; Nifedipine; Postnatal Care; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prevalence; United States | 2016 |
Postpartum Hypertension: Etiology, Diagnosis, and Management.
Topics: Antihypertensive Agents; Blood Pressure; Disease Management; Female; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Labetalol; Nifedipine; Postpartum Period; Pregnancy; Puerperal Disorders | 2017 |
Focused Update on Pharmacologic Management of Hypertensive Emergencies.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Emergencies; Enalaprilat; Female; Guideline Adherence; Heart Failure; Humans; Hydralazine; Hypertension; Infusions, Intravenous; Intracranial Hemorrhages; Labetalol; Nifedipine; Pre-Eclampsia; Pregnancy; Pyridines; Stroke | 2018 |
Drugs for treating severe hypertension in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials.
Topics: Antihypertensive Agents; Dose-Response Relationship, Drug; Female; Headache; Humans; Hydralazine; Hypertension; Hypotension; Incidence; Labetalol; Network Meta-Analysis; Nifedipine; Perinatal Death; Pregnancy; Pregnancy Complications, Cardiovascular; Randomized Controlled Trials as Topic; Stillbirth; Tachycardia; Treatment Outcome | 2018 |
Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials.
Topics: Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Hypertension, Pregnancy-Induced; Infant, Newborn; Labetalol; Network Meta-Analysis; Nifedipine; Pregnancy; Randomized Controlled Trials as Topic | 2022 |
Hypertensive Crisis in Pregnancy.
Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Hypertension; Labetalol; Nifedipine; Pregnancy | 2022 |
Treatment of acute-onset hypertension in pregnancy: A network meta-analysis of randomized controlled trials comparing anti-hypertensives and route of administration.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Female; Humans; Hydralazine; Hypertension; Infant, Newborn; Ketanserin; Methyldopa; Network Meta-Analysis; Nifedipine; Pre-Eclampsia; Pregnancy; Randomized Controlled Trials as Topic | 2023 |
25 trial(s) available for hydralazine and nifedipine
| Article | Year |
|---|---|
Antihypertensive drug effects on placental flow velocity waveforms in pregnant women with severe hypertension.
Topics: Arteries; Blood Flow Velocity; Double-Blind Method; Female; Humans; Hydralazine; Hypertension; Nifedipine; Placenta; Pregnancy; Pregnancy Complications, Cardiovascular; Pulsatile Flow; Ultrasonography; Umbilical Arteries; Uterus; Vascular Resistance | 1992 |
[Effects of corinfar, nitrosorbide and apressin on external respiration and blood flow in chronic obstructive bronchitis].
Topics: Blood Circulation; Bronchitis; Humans; Hydralazine; Hypertension, Pulmonary; Isosorbide Dinitrate; Nifedipine; Pulmonary Circulation; Pulmonary Heart Disease; Respiration; Respiratory Function Tests | 1992 |
[Management of severe pre-eclampsia in the puerperium. Comparative study of sublingual nifedipine and hydralazine].
Topics: Administration, Sublingual; Adolescent; Adult; Antihypertensive Agents; Female; Humans; Hydralazine; Nifedipine; Pre-Eclampsia; Pregnancy; Puerperal Disorders | 1991 |
Effects of nifedipine versus hydralazine on sympathetic activity and cardiac function in patients with hypertension persisting on diuretic plus beta-blocker therapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Catecholamines; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Posture; Renin; Stroke Volume; Sympathetic Nervous System; Tablets | 1990 |
Nifedipine in the treatment of severe preeclampsia.
Topics: Adult; Blood Pressure; Female; Humans; Hydralazine; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third | 1991 |
[Differential use of peripheral vasodilators in the treatment of chronic circulatory failure in patients with mitral valve insufficiency].
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Hydralazine; Middle Aged; Mitral Valve Insufficiency; Nifedipine; Nitroglycerin; Vasodilator Agents | 1990 |
Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.
Topics: Absorption; Adrenergic beta-Antagonists; Angina Pectoris; Animals; Blood Platelets; Calcium Channel Blockers; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Circulation; Drug Interactions; Heart Conduction System; Heart Failure; Hemodynamics; Histamine Release; Humans; Hydralazine; Hypertension; Kidney; Kinetics; Myocardial Infarction; Nifedipine; Oxygen Consumption; Physical Exertion | 1985 |
Effect of digoxin and vasodilators on left ventricular function in aortic regurgitation.
Topics: Adult; Analysis of Variance; Aortic Valve Insufficiency; Digoxin; Echocardiography; Exercise Test; Heart Ventricles; Humans; Hydralazine; Male; Middle Aged; Nifedipine; Stroke Volume | 1989 |
Nifedipine tablet vs. hydralazine in patients with persisting hypertension who receive combined diuretic and beta-blocker therapy.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Random Allocation | 1986 |
Neurohumoral consequences of vasodilator therapy with hydralazine and nifedipine in severe congestive heart failure.
Topics: Adult; Aged; Aldosterone; Catecholamines; Drug Therapy, Combination; Epinephrine; Female; Heart Failure; Hemodynamics; Humans; Hydralazine; Male; Middle Aged; Neurotransmitter Agents; Nifedipine; Norepinephrine; Renin | 1986 |
Felodipine vs hydralazine: a controlled trial as third line therapy in hypertension. Cooperative Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Double-Blind Method; Felodipine; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Random Allocation | 1986 |
Treatment of pulmonary hypertension with diltiazem in a child with bronchopulmonary dysplasia.
Topics: Albuterol; Bronchopulmonary Dysplasia; Child, Preschool; Diltiazem; Humans; Hydralazine; Hypertension, Pulmonary; Infant, Newborn; Isoproterenol; Male; Nifedipine; Oxygen Inhalation Therapy; Pulmonary Heart Disease | 1988 |
Comparison of nifedipine, prazosin and hydralazine added to treatment of hypertensive patients uncontrolled by thiazide diuretic plus beta-blocker.
Topics: Adult; Aged; Atenolol; Bendroflumethiazide; Blood Pressure; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Prazosin; Random Allocation | 1987 |
Efficacy and safety comparison of nitrendipine and hydralazine as antihypertensive monotherapy.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Random Allocation; Time Factors | 1984 |
Effects of nitrendipine and hydralazine on plasma catecholamines in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Chromatography, High Pressure Liquid; Dopamine; Drug Evaluation; Epinephrine; Heart Rate; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Norepinephrine; Posture | 1984 |
Role of nifedipine in the treatment of resistant hypertension. Comparison with hydralazine in hospital outpatients.
Topics: Double-Blind Method; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Outpatients; Random Allocation | 1984 |
Comparison of captopril, hydralazine and nifedipine as third drug in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Benzothiadiazines; Captopril; Diuretics; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 1993 |
[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents].
Topics: Administration, Sublingual; Antihypertensive Agents; Apgar Score; Drug Evaluation; Eclampsia; Female; Humans; Hydralazine; Infant, Newborn; Infusions, Parenteral; Longitudinal Studies; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Prospective Studies | 1993 |
Sublingual nifedipine compared with intravenous hydrallazine in the acute treatment of severe hypertension in pregnancy: potential for use in rural practice.
Topics: Administration, Sublingual; Antihypertensive Agents; Calcium Channel Blockers; Female; Humans; Hydralazine; Hypertension; Infusions, Intravenous; Injections, Intravenous; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular; Rural Population | 1996 |
Oral nifedipine therapy in the management of severe preeclampsia.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Female; Humans; Hydralazine; Infusions, Intravenous; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prospective Studies; Vasodilator Agents | 1995 |
Characterization of von Willebrand factor in primary pulmonary hypertension.
Topics: Adrenergic beta-Agonists; Adult; Antigens; Biomarkers; Blotting, Western; Calcium Channel Blockers; Electrocardiography; Electrophoresis, Agar Gel; Endothelium, Vascular; Female; Humans; Hydralazine; Hypertension, Pulmonary; Infusions, Intra-Arterial; Isoproterenol; Male; N-Acetylneuraminic Acid; Nifedipine; Prognosis; Pulmonary Artery; Pulmonary Wedge Pressure; Vasodilation; Vasodilator Agents; von Willebrand Factor | 1999 |
Nifedipine or hydralazine as a first-line agent to control hypertension in severe preeclampsia.
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Nifedipine; Pre-Eclampsia; Pregnancy; Single-Blind Method; Vasodilator Agents | 2002 |
Comparison of the efficacy of nifedipine and hydralazine in hypertensive crisis in pregnancy.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hydralazine; Hypertension; Infusions, Intravenous; Nifedipine; Pregnancy; Pregnancy Complications | 2011 |
Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial.
Topics: Acute Disease; Adolescent; Adult; Apgar Score; Double-Blind Method; Emergencies; Female; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Hypotension; Injections, Intravenous; Labor, Induced; Nausea; Nifedipine; Pregnancy; Severity of Illness Index; Time Factors; Treatment Outcome; Vasodilator Agents; Vomiting; Young Adult | 2017 |
Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia: a randomized control trial.
Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Labetalol; Nifedipine; Pre-Eclampsia; Pregnancy | 2022 |
103 other study(ies) available for hydralazine and nifedipine
| Article | Year |
|---|---|
Synthesis and antihypertensive activity of substituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Biological Assay; Hypertension; Indicators and Reagents; Magnetic Resonance Spectroscopy; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Comparison of the in vitro effects of prazosin, nifedipine, and dihydralazine in isolated human mesenteric and crural vessels.
Topics: Adolescent; Adult; Aged; Calcium; Dihydralazine; Humans; Hydralazine; In Vitro Techniques; Leg; Mesenteric Arteries; Mesenteric Veins; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Prazosin; Pyridines; Quinazolines | 1979 |
Antihypertensive effect of nifedipine on conscious renal-hypertensive dogs.
Topics: Animals; Antihypertensive Agents; Dogs; Female; Hemodynamics; Hydralazine; Hypertension, Renal; Male; Myocardium; Nifedipine; Oxygen Consumption; Pyridines | 1979 |
Similar effects of nifedipine and hydralazine on anaesthesia and hypermotility induced by pentobarbitone in mice.
Topics: Anesthesia; Animals; Drug Interactions; Hemodynamics; Hydralazine; Male; Mice; Motor Activity; Nifedipine; Pentobarbital; Sleep | 1992 |
Nifedipine-morphine interaction: a further investigation on nociception and locomotor activity in mice.
Topics: Animals; Drug Interactions; Hydralazine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Nifedipine; Nociceptors; Pain Measurement | 1992 |
The effect of vasodilators on pulmonary hemodynamics in high altitude pulmonary edema: a comparison.
Topics: Altitude Sickness; Echocardiography, Doppler; Hemodynamics; Humans; Hydralazine; Nifedipine; Phentolamine; Pulmonary Circulation; Pulmonary Edema; Vasodilator Agents | 1992 |
Comparison of the effects of hydralazine and nifedipine on contractions and 45Ca influx of rat aorta.
Topics: Animals; Calcium Radioisotopes; Hydralazine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rats; Rats, Inbred Strains | 1991 |
Intravenously administered labetalol for treatment of hypertension in children.
Topics: Adolescent; Child; Child, Preschool; Creatinine; Diazoxide; Heart Rate; Humans; Hydralazine; Hypertension; Infusions, Intravenous; Labetalol; Nifedipine; Nitroprusside; Potassium; Time Factors | 1992 |
Effect of antihypertensive therapy in experimental chronic renal failure.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dietary Proteins; Heart; Hydralazine; Kidney Failure, Chronic; Kidney Function Tests; Lipids; Male; Nephrectomy; Nephrocalcinosis; Nifedipine; Organ Size; Rats; Rats, Inbred Strains | 1991 |
Scleroderma hypertensive renal crisis and the changing pattern of mortality in systemic sclerosis (scleroderma)
Topics: Adult; Captopril; Female; Humans; Hydralazine; Hypertension, Renal; Kidney; Male; Middle Aged; Minoxidil; Nifedipine; Nitroprusside; Scleroderma, Systemic | 1991 |
Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure.
Topics: Adult; Animals; Cardiac Output, Low; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary Vessels; Felodipine; Humans; Hydralazine; Hypertension; Metoprolol; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance | 1990 |
Effects of antihypertensive drugs on experimental cerebral ischemia in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Brain Chemistry; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulation; Energy Metabolism; Hydralazine; Lactates; Male; Nifedipine; Pyruvates; Rats; Rats, Inbred SHR | 1990 |
Chronic antihypertensive drug treatment decreases protein kinase C activity in platelets from SHR.
Topics: Animals; Antihypertensive Agents; Blood Platelets; Enalapril; Hydralazine; Male; Nifedipine; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors | 1990 |
Vasodilators and hypertensive encephalopathy following scorpion envenomation in children.
Topics: Acute Disease; Animals; Brain Diseases; Child; Child, Preschool; Humans; Hydralazine; Hypertension; Infant; Nifedipine; Scorpion Stings; Scorpions | 1990 |
Effects of calcium channel blockers and hydralazine on plasma glucose levels in streptozotocin-induced diabetic rats in vivo.
Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Catecholamines; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hexamethonium Compounds; Hydralazine; Male; Nicardipine; Nifedipine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Starvation | 1990 |
Calcium entry blockade and alpha-adrenergic responsiveness in vivo.
Topics: Animals; Azepines; Blood Pressure; Calcium Channel Blockers; Hydralazine; Nifedipine; Nitrendipine; Nitroprusside; Rats; Receptors, Adrenergic, alpha; Vasoconstriction | 1985 |
Platelet antiaggregatory substances inhibit arachidonic acid induced coronary constriction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Cardiovascular Agents; Coronary Circulation; Dipyridamole; Epoprostenol; Guinea Pigs; Heart; Hydralazine; Iloprost; In Vitro Techniques; Male; Nifedipine; Perfusion; Platelet Aggregation; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Effect of calcium antagonists on hypertension and diabetes in new hypertensive diabetic models.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diltiazem; Disease Models, Animal; Female; Glucose Tolerance Test; Heart; Hydralazine; Hypertension; Kidney; Nifedipine; Organ Size; Rats; Rats, Inbred SHR | 1987 |
[Primary pulmonary hypertension: physiopathology and critical evaluation of the therapy].
Topics: Blood Pressure; Captopril; Drug Evaluation; Epoprostenol; Humans; Hydralazine; Hypertension, Pulmonary; Nifedipine; Prognosis; Pulmonary Circulation | 1989 |
A study on the hypotensive mechanism of pinacidil: relationship between its vasodilating effect and intracellular Ca2+ levels.
Topics: Animals; Antihypertensive Agents; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Hydralazine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Rabbits; Sulfonamides; Trifluoperazine; Vasodilation | 1989 |
Calcium-force coupling mechanisms during vasodilator-induced relaxation of ferret aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Carnivora; Colforsin; Ferrets; Hydralazine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nifedipine | 1989 |
Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Hydralazine; Melphalan; Mice; Neoplasms, Experimental; Nifedipine; Vasodilator Agents; Verapamil | 1989 |
Effects of calcium channel blockers and hydralazine on epinephrine-induced hyperglycemia in vivo.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Epinephrine; Food Deprivation; Glucose Tolerance Test; Hydralazine; Hyperglycemia; Male; Nicardipine; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Treatment of hypertension with calcium antagonists.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Costs and Cost Analysis; Diuretics; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Prospective Studies; Retrospective Studies; Verapamil | 1985 |
Hypotensive effects of dihydropyridine derivatives.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Hydralazine; Nicardipine; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1985 |
Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli.
Topics: Animals; Caffeine; Colon; Coronary Vessels; Female; Guanidines; Guinea Pigs; Hydralazine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium; Swine; Vasodilator Agents | 1986 |
Calcium entry blockade by nitrendipine and alpha adrenergic responsiveness in vivo: comparison with noncalcium entry blocker vasodilators in absence and presence of phenoxybenzamine pretreatment.
Topics: Animals; Azepines; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Hydralazine; Methoxamine; Nifedipine; Nitrendipine; Nitroprusside; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasodilator Agents | 1985 |
Guidelines for vasodilator therapy of congestive heart failure in infants and children.
Topics: Captopril; Child; Child, Preschool; Enalapril; Heart Diseases; Heart Failure; Heart Ventricles; Hemodynamics; Humans; Hydralazine; Infant; Nifedipine; Nitroglycerin; Nitroprusside; Phentolamine; Prazosin; Vasodilator Agents | 1987 |
Antihypertensive effects of the new calcium antagonist benidipine hydrochloride in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Heart Rate; Hydralazine; Hypertension; Male; Nicardipine; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin; Urination | 1988 |
The measurement of drug-induced calcium changes in vascular smooth muscle using X-ray microanalysis of pyroantimonate precipitates.
Topics: Animals; Antimony; Calcium; Chemical Precipitation; Electron Probe Microanalysis; Glutaral; Hydralazine; Male; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred Strains | 1987 |
Effect of posture, hydralazine, and nifedipine on hemodynamics, ventilation, and gas exchange in patients with chronic obstructive pulmonary disease.
Topics: Carbon Dioxide; Carbon Monoxide; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Lung Diseases, Obstructive; Male; Middle Aged; Nifedipine; Posture; Pulmonary Gas Exchange; Respiration; Respiratory Function Tests; Vasodilator Agents | 1988 |
Antianginal effects of the new calcium antagonist benidipine hydrochloride in anesthetized rats and spontaneously hypertensive rats. Electrocardiographic study.
Topics: Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Electrocardiography; Heart Rate; Hydralazine; Isoproterenol; Male; Nifedipine; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Vasopressins | 1988 |
Prostaglandin E1 as a screening vasodilator in primary pulmonary hypertension.
Topics: Adult; Aged; Alprostadil; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Male; Middle Aged; Nifedipine; Oxygen; Pulmonary Circulation; Pulmonary Gas Exchange; Vasodilator Agents | 1987 |
[Pharmacological studies on pinacidil, a new antihypertensive agent. (3). Studies on the vasodilating effects in isolated monkey arteries and the peripheral hypotensive mechanism in SHR].
Topics: Animals; Antihypertensive Agents; Arteries; Guanidines; Heart Rate; Hydralazine; In Vitro Techniques; Macaca fascicularis; Nifedipine; Pinacidil; Rats; Rats, Inbred SHR; Stimulation, Chemical; Vasodilation | 1987 |
Comparative study on acute antihypertensive effects and pharmacokinetics of nisoldipine, nifedipine, nimodipine and nicardipine administered orally to conscious renal hypertensive dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hydralazine; Hypertension, Renal; Kinetics; Male; Nicardipine; Nifedipine; Nimodipine; Nisoldipine; Time Factors | 1986 |
Calcium entry blockers: antihypertensive and natriuretic effects in experimental animals.
Topics: Angiotensin II; Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Glomerular Filtration Rate; Heart Rate; Hydralazine; Kidney; Natriuresis; Nifedipine; Rana catesbeiana; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Renin-Angiotensin System; Urinary Bladder | 1985 |
Drugs for hypertensive emergencies.
Topics: Administration, Oral; Captopril; Clonidine; Diazoxide; Emergencies; Humans; Hydralazine; Hypertension; Infusions, Parenteral; Labetalol; Nifedipine; Nitroprusside; Trimethaphan | 1985 |
Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog.
Topics: Anesthesia; Animals; Dinoprost; Dogs; Epoprostenol; Female; Hemodynamics; Hydralazine; Male; Nifedipine; Nitroprusside; Prostaglandin D2; Prostaglandins D; Prostaglandins F; Prostaglandins, Synthetic; Stereoisomerism; Vasodilation; Verapamil | 1985 |
Comparative effects of vasodilator drugs on flow distribution and venous return.
Topics: Animals; Blood Pressure; Captopril; Dogs; Hemodynamics; Hydralazine; Models, Biological; Nifedipine; Prazosin; Regional Blood Flow; Time Factors; Vascular Resistance; Vasodilator Agents | 1985 |
Effects of felodipine on resistance and capacitance vessels in patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Blood Vessels; Electrocardiography; Felodipine; Heart Rate; Humans; Hydralazine; Hypertension; Middle Aged; Nifedipine; Nitroglycerin; Stroke Volume; Vascular Resistance | 1985 |
Magnitude and implications of spontaneous hemodynamic variability in primary pulmonary hypertension.
Topics: Adult; Blood Pressure; Cardiac Output; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Male; Middle Aged; Nifedipine; Pulmonary Artery; Vascular Resistance | 1985 |
Effects of felodipine on renal function in animals.
Topics: Animals; Antihypertensive Agents; Dogs; Felodipine; Glomerular Filtration Rate; Hemodynamics; Hydralazine; Hypertension; Kidney; Nifedipine; Potassium; Rats; Rats, Inbred SHR; Renal Circulation; Sodium | 1985 |
Haemodynamic effects of short and long term administration of felodipine in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Cardiac Output; Coronary Circulation; Drug Administration Schedule; Felodipine; Female; Heart Rate; Hemodynamics; Hydralazine; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex; Regional Blood Flow; Stroke Volume; Time Factors | 1985 |
[Peripheral vasodilator in cardiac insufficiency in the acute period of myocardial infarction].
Topics: Cardiomyopathy, Dilated; Drug Therapy, Combination; Heart Failure; Hemodynamics; Humans; Hydralazine; Isosorbide Dinitrate; Myocardial Infarction; Nifedipine; Vasodilator Agents | 1985 |
Effect of vasodilators at rest and during exercise in young adults with cystic fibrosis and chronic cor pulmonale.
Topics: Adult; Chronic Disease; Cystic Fibrosis; Exercise Test; Female; Hemodynamics; Humans; Hydralazine; Male; Nifedipine; Oxygen; Phentolamine; Physical Exertion; Pulmonary Heart Disease; Pulmonary Wedge Pressure; Vascular Resistance; Vasodilator Agents | 1985 |
The effect of vasodilator therapy on the clinical outcome of patients with primary pulmonary hypertension.
Topics: Adolescent; Adult; Child; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Male; Middle Aged; Nifedipine; Time Factors; Vascular Resistance; Vasodilator Agents | 1985 |
Pulmonary hypertension in systemic lupus erythematosus.
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension, Pulmonary; Lupus Erythematosus, Systemic; Nifedipine; Prednisone; Pulmonary Circulation; Vascular Resistance | 1985 |
The role of vasodilators in patients with progressive systemic sclerosis. Interstitial lung disease and pulmonary hypertension.
Topics: Humans; Hydralazine; Hypertension, Pulmonary; Lung Diseases; Nifedipine; Pulmonary Fibrosis; Sarcoidosis; Scleroderma, Systemic | 1985 |
[Pharmacological studies on pinacidil, a new anti-hypertensive agent. 1. Antihypertensive effects in SHR and DOC/saline hypertensive rats].
Topics: Administration, Oral; Animals; Antihypertensive Agents; Desoxycorticosterone; Female; Guanidines; Hydralazine; Hypertension; Male; Nifedipine; Pinacidil; Rats; Rats, Inbred SHR; Sex Factors; Sodium Chloride | 1985 |
Effect of chronic elevation of plasma calcium concentration by PTH or vitamin D3 on blood pressure and hypotensive activity of nifedipine in rats.
Topics: Animals; Blood Pressure; Calcium; Cholecalciferol; Hydralazine; Male; Nifedipine; Parathyroid Hormone; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Arachidonic acid metabolism in isolated aorta and lung of the rat: effects of dipyridamole, nifedipine, propranolol, hydralazine and verapamil.
Topics: Animals; Antihypertensive Agents; Aorta; Arachidonic Acids; Autacoids; Dipyridamole; Hydralazine; Lung; Male; Nifedipine; Propranolol; Rats; Vasodilator Agents; Verapamil | 1983 |
Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: systemic and coronary hemodynamics with and without combined beta adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dogs; Female; Heart Rate; Hemodynamics; Hydralazine; Male; Nifedipine; Nisoldipine; Nitrendipine; Propranolol; Vasodilator Agents | 1984 |
Acute effects of the calcium antagonist, nifedipine, on blood pressure, pulse rate, and the renin-angiotensin-aldosterone system in patients with essential hypertension.
Topics: Adult; Age Factors; Aldosterone; Angiotensin I; Angiotensin II; Blood Pressure; Calcium; Heart Rate; Humans; Hydralazine; Hydrocortisone; Hypertension; Middle Aged; Nifedipine; Peptidyl-Dipeptidase A; Pyridines; Renin; Renin-Angiotensin System | 1982 |
Hemodynamic effects of nifedipine versus hydralazine in primary pulmonary hypertension.
Topics: Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Infusions, Parenteral; Nifedipine; Pulmonary Wedge Pressure; Vascular Resistance | 1984 |
Differential influence of the calcium antagonist nitrendipine and the vasodilator hydralazine on normal and elevated blood pressure.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Heart Rate; Hydralazine; Hypertension; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains | 1984 |
Adverse hemodynamic and clinical effects of calcium channel blockade in pulmonary hypertension secondary to obliterative pulmonary vascular disease.
Topics: Adult; Calcium Channel Blockers; Cardiac Output; Exercise Test; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Male; Middle Aged; Nifedipine; Pulmonary Artery; Pulmonary Circulation; Pulmonary Wedge Pressure; Vascular Resistance; Verapamil | 1984 |
Renal hemodynamic effects of vasodilation with nifedipine and hydralazine in patients with heart failure.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Glomerular Filtration Rate; Heart Failure; Humans; Hydralazine; Middle Aged; Nifedipine; Random Allocation; Renal Artery; Renal Circulation; Renal Veins; Time Factors; Vascular Resistance | 1984 |
Comparative actions of hydralazine, nifedipine and amrinone in primary pulmonary hypertension.
Topics: Adult; Aminopyridines; Amrinone; Cardiac Catheterization; Cardiac Output; Female; Humans; Hydralazine; Hypertension, Pulmonary; Male; Middle Aged; Nifedipine; Pulmonary Wedge Pressure; Stroke Volume; Vascular Resistance; Vasodilator Agents | 1983 |
Drugs can help oesophageal motility disorders.
Topics: Esophageal Achalasia; Esophageal Diseases; Humans; Hydralazine; Nifedipine; Nitrates | 1984 |
Differences in hemodynamic response to vasodilation due to calcium channel antagonism with nifedipine and direct-acting agonism with hydralazine in chronic refractory congestive heart failure.
Topics: Adult; Aged; Blood Pressure; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Hydralazine; Male; Middle Aged; Nifedipine; Pulmonary Wedge Pressure; Random Allocation; Stroke Volume; Vascular Resistance | 1984 |
Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists.
Topics: Animals; Dimethyl Sulfoxide; Hydralazine; Hypertension, Pulmonary; Hypoxia; Male; Nifedipine; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vascular Resistance; Verapamil | 1984 |
Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: alterations in baroreflex sensitivity.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dogs; Female; Heart Rate; Hydralazine; Male; Nifedipine; Nisoldipine; Nitrendipine; Pressoreceptors | 1984 |
Hemodynamic effects of nifedipine in primary pulmonary hypertension.
Topics: Adult; Exercise Test; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Nifedipine; Pulmonary Wedge Pressure; Pyridines; Vascular Resistance; Vasodilator Agents | 1983 |
Hydralazine in pulmonary hypertension.
Topics: Humans; Hydralazine; Hypertension, Pulmonary; Lung Diseases, Obstructive; Nifedipine | 1982 |
The effects of nifedipine and hydralazine induced hypotension on sympathetic activity.
Topics: Adult; Blood Pressure; Heart Rate; Humans; Hydralazine; Male; Nifedipine; Norepinephrine; Pyridines; Sympathetic Nervous System | 1982 |
Effect of a new calcium antagonist, nitrendipine, on blood pressure and heart rate of conscious, unrestrained dogs.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hydralazine; Hypertension, Renal; Male; Nifedipine; Nitrendipine; Pyridines | 1981 |
Antihypertensive effects of nifedipine on conscious normotensive and hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hydralazine; Hypertension; Hypertension, Renal; Male; Nifedipine; Pyridines; Rats; Time Factors | 1981 |
Hemodynamic effects of nifedipine in congestive heart failure.
Topics: Adult; Cardiac Output; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Hydralazine; Male; Middle Aged; Nifedipine; Pulmonary Artery; Pulmonary Edema; Pyridines; Stroke Volume; Vascular Resistance | 1980 |
Different antihypertensive effects of nifedipine in conscious experimental hypertensive and normotensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Heart Rate; Hydralazine; Hypertension; Hypertension, Renal; Male; Nifedipine; Pyridines; Rats; Time Factors | 1980 |
[Long-term treatment with quinapril in chronic aortic and mitral insufficiency].
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Aortic Valve Insufficiency; Chronic Disease; Echocardiography; Female; Follow-Up Studies; Hemodynamics; Humans; Hydralazine; Isoquinolines; Male; Middle Aged; Mitral Valve Insufficiency; Nifedipine; Nitroprusside; Prodrugs; Quinapril; Radionuclide Ventriculography; Tetrahydroisoquinolines; Time Factors | 1995 |
Effect of beraprost sodium, a stable prostacyclin analogue, on pulmonary thromboembolism in mice.
Topics: Administration, Oral; Alprostadil; Animals; Aspirin; Bridged Bicyclo Compounds; Collagen; Diltiazem; Drug Evaluation, Preclinical; Epinephrine; Epoprostenol; Fatty Acids, Monounsaturated; Fibrinolytic Agents; Heparin; Hydralazine; Injections, Intravenous; Isosorbide Dinitrate; Male; Mice; Nifedipine; Nitroprusside; Platelet Aggregation Inhibitors; Pulmonary Embolism; Superoxide Dismutase; Vasodilator Agents | 1995 |
[Individual approach to vasodilator treatment of pulmonary hypertension in chronic bronchitis].
Topics: Adult; Aminophylline; Bronchitis; Chronic Disease; Humans; Hydralazine; Hypertension, Pulmonary; Middle Aged; Nifedipine; Nitroglycerin; Time Factors; Vasodilator Agents; Verapamil | 1994 |
Nifedipine aggravates cyclosporine A-induced gingival hyperplasia.
Topics: Adolescent; Adult; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Gingival Hyperplasia; Graft Rejection; Humans; Hydralazine; Hypertension; Kidney Transplantation; Male; Nifedipine | 1994 |
Attenuation of cholinergic analgesia by nifedipine.
Topics: Analgesics; Animals; Hot Temperature; Hydralazine; Male; Mice; Mice, Inbred Strains; Nifedipine; Oxotremorine; Pain Measurement; Parasympathomimetics; Physostigmine; Reaction Time | 1993 |
Effects of calcium antagonists on endothelin-1-induced myocardial ischaemia and oedema in the rat.
Topics: Albumins; Animals; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Edema; Electrocardiography; Endothelin-1; Endothelins; Heart Rate; Hydralazine; Male; Myocardial Ischemia; Nifedipine; Peptide Fragments; Rats; Rats, Wistar; Receptors, Endothelin; Vasodilator Agents; Verapamil | 1996 |
Inhibition of calcium influx and tonic response to K+ of intestinal smooth muscle by hydralazine.
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Guinea Pigs; Hydralazine; Ileum; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium | 1996 |
Alterations in alpha subunit expression of cardiac Na+,K+-ATPase in spontaneously hypertensive rats: effect of antihypertensive therapy.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Hydralazine; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 1997 |
Vasodilators, aortic elasticity, and ventricular end-systolic stress in nonanesthetized unrestrained rats.
Topics: Animals; Aorta; Blood Pressure; Elasticity; Hydralazine; Hypotension; Male; Nifedipine; Nitroprusside; Pulsatile Flow; Rats; Rats, Wistar; Stress, Mechanical; Systole; Vasodilator Agents; Ventricular Function | 1997 |
Antihypertensive agents that limit ventricular hypertrophy inhibit cardiac expression of insulin-like growth factor-I.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enalapril; Heart; Hydralazine; Hypertension; Hypertrophy, Left Ventricular; Insulin-Like Growth Factor I; Male; Myocardium; Nifedipine; Organ Size; Rats; Rats, Inbred SHR; RNA, Messenger | 1997 |
Reduction by ATP-sensitive potassium channel opener, YM934, of experimental myocardial infarct size in anesthetized dogs.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Coronary Vessels; Cyclic N-Oxides; Dogs; Drug Evaluation, Preclinical; Female; Hemodynamics; Hydralazine; Male; Myocardial Infarction; Nifedipine; Oxazines; Potassium Channels; Vasodilator Agents | 1999 |
Apoptosis during regression of cardiac hypertrophy in spontaneously hypertensive rats. Temporal regulation and spatial heterogeneity.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Apoptosis; Calcium Channel Blockers; Cardiomegaly; Data Interpretation, Statistical; DNA; DNA Fragmentation; Enalapril; Hemodynamics; Hydralazine; Losartan; Male; Nifedipine; Propranolol; Rats; Time Factors | 1999 |
Occurrence and distribution of atrial natriuretic peptide-containing cells in the left ventricle of hypertensive rats. Effect of antihypertensive treatment.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Blotting, Northern; Captopril; Cell Size; Gene Expression; Heart Ventricles; Hydralazine; Hypertension; Immunohistochemistry; Male; Muscle Fibers, Skeletal; Myocardium; Nifedipine; Organ Size; Rats; Rats, Inbred SHR; Rats, Wistar; RNA, Messenger; Vasodilator Agents; Ventricular Function | 2001 |
Factor analysis, including antihypertensive medication, of the outcome of pregnancy in pregnancy-associated hypertension.
Topics: Antihypertensive Agents; Apgar Score; Cesarean Section; Comorbidity; Disease Susceptibility; Female; Fetal Death; Humans; Hydralazine; Hypertension; Infant, Newborn; Labetalol; Multivariate Analysis; Nifedipine; Parity; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy in Diabetics; Pregnancy Outcome; Retrospective Studies; Risk Factors | 2001 |
Persistent lowering of arterial pressure after continuous and intermittent therapy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Enalapril; Heart Rate; Heart Ventricles; Hydralazine; Hydrochlorothiazide; Hypertension; Losartan; Male; Nifedipine; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Vasodilator Agents | 2003 |
Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance.
Topics: Adult; Antihypertensive Agents; Dose-Response Relationship, Drug; Female; Fetus; Humans; Hydralazine; Labetalol; Magnesium Sulfate; Methyldopa; Nifedipine; Placenta; Pre-Eclampsia; Pregnancy; Regional Blood Flow; Umbilical Arteries; Vascular Resistance | 2004 |
The treatment of severe hypertension in pregnancy: a review of current practice and knowledge in West-Midlands maternity units.
Topics: Antihypertensive Agents; Female; Hospital Units; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Labetalol; Nifedipine; Obstetrics; Practice Patterns, Physicians'; Pregnancy | 2004 |
Impact of antihypertensive treatments on erectile responses in aging spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Apomorphine; Blood Pressure; Enalapril; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney Transplantation; Losartan; Male; Nifedipine; Penile Erection; Random Allocation; Rats; Rats, Inbred SHR; Testosterone | 2006 |
Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro.
Topics: Amlodipine; Cardiovascular Agents; Enzyme Inhibitors; Hydralazine; Kinetics; Nifedipine; Octoxynol; Simvastatin; Sterol Esterase; Taurocholic Acid | 2006 |
Simultaneous posterior ischemic optic neuropathy, cerebral border zone infarction, and spinal cord infarction after correction of malignant hypertension.
Topics: Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Brain; Brain Stem Infarctions; Cerebral Infarction; Disease Progression; Female; Fosinopril; Humans; Hydralazine; Hypertension, Malignant; Hypotension; Iatrogenic Disease; Magnetic Resonance Imaging; Nifedipine; Optic Neuropathy, Ischemic; Paraparesis; Spinal Cord; Spinal Cord Ischemia; Tetrazoles; Urinary Incontinence; Vision, Low | 2008 |
"Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Hydralazine; Hypertension; Hypertrophy; Kidney; Male; Matrix Metalloproteinase 13; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Tetrazoles; Vasodilator Agents | 2009 |
Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor.
Topics: Animals; Antihypertensive Agents; Arterioles; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebrovascular Circulation; Cerebrum; Compliance; Eplerenone; Hydralazine; Hydrochlorothiazide; Hypertension; Middle Cerebral Artery; Mineralocorticoid Receptor Antagonists; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Mineralocorticoid; Reserpine; Spironolactone; Vascular Remodeling; Vascular Stiffness | 2015 |
Severe maternal morbidity in a large cohort of women with acute severe intrapartum hypertension.
Topics: Adult; Antihypertensive Agents; California; Female; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Labetalol; Morbidity; Nifedipine; Pregnancy; Retrospective Studies; Young Adult | 2016 |
Comparison of the effects of different vasoactive and antiplatelet drugs on perforator flap viability. An experimental study.
Topics: Alprostadil; Animals; Arteries; Epigastric Arteries; Graft Survival; Hydralazine; Nifedipine; Perforator Flap; Piracetam; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2016 |
Identification of factors associated with delayed treatment of obstetric hypertensive emergencies.
Topics: Administration, Intravenous; Administration, Oral; Adult; After-Hours Care; Antihypertensive Agents; Black or African American; Chronic Disease; Emergencies; Ethnicity; Female; Gestational Age; Hispanic or Latino; Humans; Hydralazine; Hypertension; Hypertension, Pregnancy-Induced; Labetalol; Labor, Obstetric; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Retrospective Studies; Risk Factors; Severity of Illness Index; Time-to-Treatment; White People | 2020 |
Race/ethnicity differences in response to acute antihypertensive treatment of peripartum severe hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Ethnicity; Female; Humans; Hydralazine; Hypertension; Labetalol; Nifedipine; Peripartum Period; Pregnancy; Retrospective Studies | 2022 |
Trends in antihypertensive prescription for pregnant women with hypertension and their peripartum outcomes before and after label and guideline revisions in Japan.
Topics: Antihypertensive Agents; Cesarean Section; Drug Prescriptions; Female; Humans; Hydralazine; Hypertension; Infant, Newborn; Japan; Methyldopa; Nifedipine; Peripartum Period; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Retrospective Studies | 2022 |