hydralazine and metoprolol

hydralazine has been researched along with metoprolol in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (57.50)	18.7374
1990's	7 (17.50)	18.2507
2000's	5 (12.50)	29.6817
2010's	4 (10.00)	24.3611
2020's	1 (2.50)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dirix, R; Savoye, D; Tyberghein, JM	1
Sandström, B	3
Bahner, U; Heidland, A; Schaefer, RM; Teschner, M	1
Janssen, BJ; Struyker-Boudier, HA; Tyssen, CM	1
Christensen, KL	1
Strauer, BE	1
Allen, TJ; Clarke, BE; Cooper, ME; Doyle, AE; Jerums, G; O'Brien, RC; Papazoglou, D	1
Christensen, KL; Jespersen, LT; Mulvany, MJ	1
Baandrup, U; Christensen, HR; Christensen, KL; Jespersen, LT; Nielsen, H	1
Baba, T; Sawicki, PT	1
Hommel, E; Mathiesen, ER; Parving, HH	1
Carlsen, JE; Kardel, T; Lund, JO; McNair, A; Trap-Jensen, J	1
Katus, H; Mall, G; Mehls, O; Rambausek, M; Ritz, E	1
Holm, B; Lindeberg, S; Lundborg, P; Regårdh, CG; Sandström, B	1
Alderman, MH; Marantz, PR; Tobin, JN	1
Black, DM; Furberg, CD	1
Knowlton, PW; Svensson, CK; Ware, JA	1
Olkkonen, H; Pääkkönen, A; Saarikoski, S; Suonio, S; Tahvanainen, K	1
Magnusson, H; Pontén, J; Sonander, HG	1
Axelsson, O; Högstedt, S; Lindberg, BS; Lindeberg, S; Lindmark, G; Rane, A; Sandström, B	1
Blumlein, SL; Kidd, P; Parmley, WW; Sievers, R	1
Dols, DM; Houtzagers, JJ; Meems, L	1
Lindeberg, S; Lundborg, P; Regårdh, CG; Sandström, B	1
Freed, CR; Gerber, JG; Nies, AS	1
Honkavaara, M; Nissinen, A; Tuomilehto, J	1
Bonnevie-Nielsen, V; Broch-Møller, B; Kølendorf, K	1
Deng, LY; Schiffrin, EL	1
Aurell, M; Berglund, G; Hartford, M; Lindstedt, G; Ljungman, S; Wikstrand, J	1
Bolen, MA; Halliburton, SS; Schoenhagen, P	1
Abudiab, MM; Odunukan, OW; Sinak, LJ	1
Biswas, A; Chen, X; Ghazi, L; Hanna, J; Li, F; Peixoto, AJ; Shah, T; Simonov, M; Wilson, FP; Yamamoto, Y	1

Reviews

4 review(s) available for hydralazine and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Nephropathy in type 1 diabetes mellitus. Current experimental and clinical aspects]. Deutsche medizinische Wochenschrift (1946), 1992, Nov-06, Volume: 117, Issue:45 Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diuretics; Endopeptidases; Furosemide; Humans; Hydralazine; Kidney Glomerulus; Metoprolol; Rats; Risk Factors	1992
Diagnostic heterogeneity in clinical trials for congestive heart failure. Annals of internal medicine, 1988, Jul-01, Volume: 109, Issue:1 Topics: Amrinone; Clinical Trials as Topic; Digoxin; Heart Failure; Humans; Hydralazine; Metoprolol; Research Design	1988
Antihypertensive pharmacology. The Western journal of medicine, 1980, Volume: 132, Issue:5 Topics: Adolescent; Adult; Antihypertensive Agents; Clonidine; Diazoxide; Diuretics; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Metoprolol; Minoxidil; Nitroprusside; Patient Compliance; Prazosin; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors	1980

Trials

6 trial(s) available for hydralazine and metoprolol

Article	Year
Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiac Output; Double-Blind Method; Drug Evaluation; Drug Interactions; Female; Guanidines; Heart Rate; Hemodynamics; Humans; Hydralazine; Hypertension; Injections, Intravenous; Male; Metoprolol; Middle Aged; Pinacidil; Random Allocation; Stroke Volume; Vascular Resistance	1985
The systolic hypertension in the elderly pilot program: methodological issues. European heart journal, 1988, Volume: 9, Issue:2 Topics: Age Factors; Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Feasibility Studies; Female; Humans; Hydralazine; Hypertension; Male; Metoprolol; Middle Aged; Patient Compliance; Pilot Projects; Random Allocation; Reserpine; Sex Factors; Systole	1988
Methohexitone anaesthesia for microlaryngoscopy: circulatory modulation with metoprolol and dihydralazine. British journal of anaesthesia, 1986, Volume: 58, Issue:9 Topics: Aged; Anesthesia, Intravenous; Arrhythmias, Cardiac; Blood Pressure; Dihydralazine; Female; Heart Rate; Humans; Hydralazine; Intraoperative Complications; Laryngoscopy; Male; Methohexital; Metoprolol; Middle Aged; Premedication	1986
A prospective controlled trial of metoprolol-hydralazine treatment in hypertension during pregnancy. Acta obstetricia et gynecologica Scandinavica, 1985, Volume: 64, Issue:6 Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fetus; Gestational Age; Humans; Hydralazine; Hypertension; Labor, Induced; Maternal-Fetal Exchange; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Prospective Studies	1985
Clinical evaluation of the antihypertensive effect of metoprolol in combination with hydrochlorothiazide and hydralazine in an unselected hypertensive population. Acta cardiologica, 1980, Volume: 35, Issue:4 Topics: Adult; Antihypertensive Agents; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Lipids; Male; Metoprolol; Middle Aged; Propanolamines	1980
A trial of metoprolol in hypertensive insulin-dependent diabetic patients. Acta medica Scandinavica, 1982, Volume: 211, Issue:3 Topics: Adult; Aged; Benzothiadiazines; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Diuretics; Female; Humans; Hydralazine; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Sodium Chloride Symporter Inhibitors	1982

Other Studies

30 other study(ies) available for hydralazine and metoprolol

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Drug treatment of essential hypertension. Practical guidelines. The Practitioner, 1979, Volume: 222, Issue:1331 Topics: Adult; Aged; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines	1979
Antihypertensive treatment with the adrenergic beta-receptor blocker metoprolol during pregnancy. Gynecologic investigation, 1978, Volume: 9, Issue:4 Topics: Apgar Score; Drug Evaluation; Drug Therapy, Combination; Female; Fetal Growth Retardation; Fetus; Humans; Hydralazine; Hypertension; Infant Mortality; Infant, Newborn; Male; Metoprolol; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Propanolamines	1978
Modification of circadian blood pressure and heart rate variability by five different antihypertensive agents in spontaneously hypertensive rats. Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Heart Rate; Hydralazine; Hypertension; Male; Metoprolol; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY	1991
Reducing pulse pressure in hypertension may normalize small artery structure. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 18, Issue:6 Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Captopril; Dihydropyridines; Heart Rate; Hydralazine; Hypertension; Indoles; Isradipine; Male; Metoprolol; Perindopril; Pulse; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regression Analysis	1991
Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure. The American journal of cardiology, 1990, Apr-03, Volume: 65, Issue:14 Topics: Adult; Animals; Cardiac Output, Low; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary Vessels; Felodipine; Humans; Hydralazine; Hypertension; Metoprolol; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance	1990
Nephropathy in model combining genetic hypertension with experimental diabetes. Enalapril versus hydralazine and metoprolol therapy. Diabetes, 1990, Volume: 39, Issue:12 Topics: Administration, Oral; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Drug Therapy, Combination; Enalapril; Hydralazine; Hypertension; Kidney; Kidney Glomerulus; Male; Metoprolol; Rats; Rats, Inbred SHR	1990
Development of blood pressure in spontaneously hypertensive rats after withdrawal of long-term treatment related to vascular structure. Journal of hypertension, 1989, Volume: 7, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Hydralazine; Hypertension; Indoles; Isradipine; Male; Mesenteric Arteries; Mesenteric Veins; Metoprolol; Perindopril; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vascular Resistance	1989
Antitrophic properties of antihypertensive drugs may depend solely on their blood pressure-lowering capability. A comparative study of isradipine, hydralazine, and metoprolol. The American journal of medicine, 1989, Apr-17, Volume: 86, Issue:4A Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Coronary Vessels; Hydralazine; Isradipine; Male; Metoprolol; Pyridines; Rats; Rats, Inbred SHR; Vascular Resistance	1989
Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat: are these effects specific for enalapril? Diabetologia, 1989, Volume: 32, Issue:11 Topics: Albuminuria; Animals; Basement Membrane; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination; Enalapril; Hydralazine; Hypertension; Kidney Glomerulus; Metoprolol; Rats	1989
Converting enzyme-inhibition in diabetic nephropathy. Contributions to nephrology, 1989, Volume: 73 Topics: Albuminuria; Blood Pressure; Captopril; Diabetic Nephropathies; Drug Therapy, Combination; Furosemide; Glomerular Filtration Rate; Humans; Hydralazine; Hypertension; Metoprolol; Prospective Studies	1989
Myocardial hypertrophy in rats with renal insufficiency. Kidney international, 1985, Volume: 28, Issue:5 Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Blood Transfusion; Calcium; Cardiomegaly; Hydralazine; Isoenzymes; Kidney Diseases; Male; Metoprolol; Microscopy, Electron; Myocardium; Myosins; Nadolol; Nephrectomy; Organ Size; Parathyroid Glands; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Trifluoperazine	1985
The effect of hydralazine on steady-state plasma concentrations of metoprolol in pregnant hypertensive women. European journal of clinical pharmacology, 1988, Volume: 35, Issue:2 Topics: Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Time Factors	1988
Effect of hydralazine on the elimination of antipyrine in the rat. Pharmaceutical research, 1987, Volume: 4, Issue:6 Topics: Administration, Oral; Animals; Antipyrine; Biological Availability; Body Temperature; Drug Synergism; Hydralazine; Metoprolol; Propranolol; Rats; Rats, Inbred Strains	1987
Acute effects of dihydralazine mesylate, furosemide, and metoprolol on maternal hemodynamics in pregnancy-induced hypertension. American journal of obstetrics and gynecology, 1986, Volume: 155, Issue:1 Topics: Adult; Blood Pressure; Blood Volume; Cardiac Output; Chorionic Villi; Dihydralazine; Female; Furosemide; Heart Rate; Hemodynamics; Humans; Hydralazine; Hypertension; Metoprolol; Pregnancy; Pregnancy Complications, Cardiovascular; Regional Blood Flow	1986
Adrenergic beta-receptor blockers in hypertension of pregnancy. Clinical and experimental hypertension. Part B, Hypertension in pregnancy, 1982, Volume: 1, Issue:1 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Birth Weight; Blood Pressure; Delivery, Obstetric; Female; Fetal Heart; Heart Rate; Humans; Hydralazine; Hypertension; Infant, Newborn; Metoprolol; Middle Aged; Milk, Human; Pregnancy; Pregnancy Complications, Cardiovascular	1982
Clinical trials of adrenergic antagonists in pregnancy hypertension. Acta obstetricia et gynecologica Scandinavica. Supplement, 1984, Volume: 118 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Apgar Score; Birth Weight; Female; Fetal Growth Retardation; Humans; Hydralazine; Hypertension; Infant, Newborn; Methyldopa; Metoprolol; Oxprenolol; Pregnancy; Pregnancy Complications, Cardiovascular; Respiratory Distress Syndrome, Newborn	1984
Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbit. The American journal of cardiology, 1984, Oct-01, Volume: 54, Issue:7 Topics: Animals; Aorta; Arteriosclerosis; Blood Pressure; Cholesterol; Cholesterol, Dietary; Heart Rate; Hydralazine; Lipids; Metoprolol; Rabbits; Triglycerides; Verapamil	1984
Slow-release metoprolol, hydrochlorothiazide and hydralazine in stepwise treatment of essential hypertension. The Netherlands journal of medicine, 1984, Volume: 27, Issue:8 Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Drug Combinations; Drug Evaluation; Female; Follow-Up Studies; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged	1984
Disposition of the adrenergic blocker metoprolol in the late-pregnant woman, the amniotic fluid, the cord blood and the neonate. Acta obstetricia et gynecologica Scandinavica. Supplement, 1984, Volume: 118 Topics: Amniotic Fluid; Drug Therapy, Combination; Female; Fetal Blood; Humans; Hydralazine; Hypertension; Infant, Newborn; Kinetics; Metoprolol; Milk, Human; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, Third	1984
Effect of antihypertensive treatment on response to endothelin of resistance arteries of hypertensive rats. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:5 Topics: Animals; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Body Weight; Cilazapril; Dose-Response Relationship, Drug; Endothelins; Heart Rate; Hydralazine; Hypertension, Renovascular; In Vitro Techniques; Mesenteric Artery, Inferior; Metoprolol; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Sprague-Dawley; Renin	1993
Effects of long-term antihypertensive treatment and aging on renal function and albumin excretion in primary hypertension. American journal of hypertension, 1993, Volume: 6, Issue:7 Pt 1 Topics: Aging; Albuminuria; Case-Control Studies; Drug Therapy, Combination; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Male; Metoprolol; Middle Aged; Renal Circulation	1993
Iterative CT reconstruction of aortic intramural hematoma. Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:7 Topics: Amlodipine; Aortic Aneurysm; Aortic Dissection; Captopril; Drug Therapy, Combination; Female; Hematoma; Humans; Hydralazine; Metoprolol; Middle Aged; Multidetector Computed Tomography; Simvastatin; Treatment Outcome	2011
48-year-old man with cough and leg swelling. Mayo Clinic proceedings, 2012, Volume: 87, Issue:12 Topics: Acute Disease; Antihypertensive Agents; Cerebrovascular Circulation; Cough; Dyspnea; Echocardiography; Edema; Emergencies; Humans; Hydralazine; Hypertension; Labetalol; Lower Extremity; Male; Metoprolol; Middle Aged; Nitroglycerin; Sleep Apnea Syndromes; Vasodilator Agents	2012
Blood pressure response to commonly administered antihypertensives for severe inpatient hypertension. PloS one, 2022, Volume: 17, Issue:4 Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Carvedilol; Cohort Studies; Humans; Hydralazine; Hypertension; Inpatients; Metoprolol	2022