hydralazine and losartan
hydralazine has been researched along with losartan in 66 studies
Research
Studies (66)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 21 (31.82) | 18.2507 |
2000's | 28 (42.42) | 29.6817 |
2010's | 17 (25.76) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
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Lombardo, F; Obach, RS; Waters, NJ | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Andoh, TF; Bennett, WM; Burdmann, EA; Coffman, TM; Connors, BA; Evan, A; Lindsley, J; Nast, CC | 1 |
Abassi, ZA; Cuda, G; Golomb, E; Keiser, HR; Panchal, VR; Stylianou, M; Trachewsky, D | 1 |
Hajj-Ali, AF; Reilly, TM; Wong, PC | 1 |
Fukui, T; Horio, T; Kohno, M; Kurihara, N; Takeda, T; Yasunari, K; Yokokawa, K; Yoshiyama, M | 1 |
Brecher, P; Chobanian, AV; Crawford, DC; Himeno, H; Hosoi, M | 1 |
Soltis, EE | 1 |
Brink, M; Delafontaine, P; Wellen, J | 1 |
Frohlich, ED; Nuñez, E; Prakash, O; Susic, D | 1 |
Capers, Q; de Leon, H; Fukui, T; Griendling, KK; Harrison, DG; Ishizaka, N; Laursen, JB; Rajagopalan, S; Taylor, WR; Wilcox, JN | 1 |
Head, RJ; Irvine, RJ; White, JM | 1 |
Böhm, M; Flesch, M; Paul, M; Pinto, YM; Schnabel, P; Teisman, AC; van Gilst, WH; Zolk, O | 1 |
Chan, R; Irvine, RJ; White, J | 1 |
Andoh, TF; Bennett, WM; Couser, WG; Johnson, RJ; Pichler, RH; Shankland, SJ; Thomas, SE | 1 |
Helmchen, U; Schneider, A; Stahl, RA; Wenzel, U; Wolf, G | 1 |
Böhm, M; Buikema, H; Flesch, M; Paul, M; Pinto, YM; Teisman, AC; van Gilst, WH | 1 |
Butcher, JW; Kasparov, S; Paton, JF | 1 |
Anderson, NH; Devlin, AM; Dominiczak, AF; Graham, D; Hamilton, CA; Morton, JJ; Reid, JL; Schork, NJ | 1 |
Li, J; Wang, DH | 1 |
Ferrario, CM; Gallagher, PE; Ganten, D; Strawn, WB; Tallant, EA | 1 |
Dam, TV; deBlois, D; Hamet, P; Moreau, P; Tea, BS | 1 |
Cody, RJ; Goetze, S; Graf, K; Hsueh, WA; Kawano, H; Kawano, Y; Law, RE; Schnee, J | 1 |
Attias, J; Breslow, JL; Brodsky, S; Coleman, R; Hayek, T; Keidar, S; Smith, J | 1 |
Aizawa, T; Ingelfinger, JR; Ishizaka, N; Mori, I; Nagai, R; Ohno, M; Taguchi, Ji; Tang, SS | 1 |
Aizawa, T; Ishizaka, N; Mori, I; Nagai, R; Ohno, M; Taguchi, J; Yazaki, Y | 1 |
Esposito, G; Fox, JE; Hagaman, JR; Knowles, JW; Maeda, N; Mao, L; Rockman, HA; Smithies, O | 1 |
Abe, I; Kagiyama, S; Lin, Y; Matsumura, K; Tsuchihashi, T | 1 |
Adams, MA; Bushfield, TL; Hale, TM; Woolard, J | 1 |
Arens, T; Dendorfer, A; Dominiak, P; Häuser, W; Qadri, F; Schwarz, EC | 1 |
de Resende, MM; Gomes, Mda G; Leite, CM; Milanez, Mda C; Mill, JG | 1 |
Alonso, C; Catalán, MP; Egido, J; Gallego-Delgado, J; Gómez-Garre, D; Largo, R; Ortiz, A; Plaza, JJ; Soto, K; Tejera, N | 1 |
Amiri, F; Brassard, P; Schiffrin, EL | 1 |
Akiyama, S; Gessei-Tsutsumi, N; Goda, M; Hobara, N; Kawasaki, H; Kurosaki, Y; Takayama, F | 1 |
Bayraktutan, U; Demirci, B; McKeown, PP | 1 |
Amiri, F; Brassard, P; Schiffrin, EL; Thibault, G | 1 |
Adams, MA; Hale, TM; Hannan, JL; Heaton, JP; Smallegange, C | 1 |
Ayabe, N; Babaev, VR; Fazio, S; Fogo, AB; Ichikawa, I; Kon, V; Linton, MF; Ma, J; Suganuma, E; Zuo, Y | 1 |
Ishizaka, N; Matsuzaki, G; Mori, I; Nagai, R; Noiri, E; Saito, K | 1 |
Baumann, M; Hermans, JJ; Janssen, BJ; Peutz-Kootstra, C; Smits, JF; Struijker Boudier, HA; Witzke, O | 1 |
Agharazii, M; Larivière, R; Lebel, M; Rodrigue, ME | 1 |
Biswas, SK; de Faria, JB; de Faria, JM; Pinto, CC; Silva, KC; Souza, DS | 1 |
Ayabe, N; Babaev, VR; Fazio, S; Fogo, AB; Ichikawa, I; Kon, V; Linton, MF; Motojima, M; Suganuma, E; Zuo, Y | 1 |
Brezniceanu, ML; Chan, JS; Chénier, I; Filep, JG; Ingelfinger, JR; Liu, F; Sachetelli, S; Wei, CC; Zhang, SL | 1 |
Fujihara, CK; Machado, FG; Malheiros, DM; Mattar, AL; Zatz, R | 1 |
Cochain, C; Duriez, M; Lévy, BI; Loinard, C; Mees, B; Silvestre, JS; Vilar, J; You, D | 1 |
Amann, K; Hartner, A; Hilgers, KF; Klanke, B; Melk, A; Steinbach, MP; Westhoff, JH | 1 |
Bartholome, R; Baumann, M; Janssen, BJ; Rob Hermans, JJ; Smits, JF; Struijker Boudier, HA | 1 |
Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F | 1 |
Chatziantoniou, C; Helle, F; Iversen, BM | 1 |
Casarini, DE; Coelho, MS; Ferreira, DN; Furukawa, LN; Heimann, JC; Katayama, IA; Oliveira, IB; Rosa, KT | 1 |
Caruso-Neves, C; Landgraf, SS; Pinheiro, AA; Silva, JS; Sudo, RT; Takiya, CM; Wengert, M; Zapata-Sudo, G | 1 |
Alewijnse, AE; Chalfant, CE; De Mey, JG; Janssen, BJ; Meens, MJ; Nelissen, J; Peters, SL; Spijkers, LJ; Wijesinghe, D | 1 |
Ascione, R; Dominiczak, AF; Giannotta, M; Graham, D; Hendy, EB; Hewinson, J; Kasparov, S; Liu, B; McBride, F; Oliveira-Sales, EB; Paton, JF; Toward, M; Waki, H; Xu, H | 1 |
Cohen Tervaert, JW; Fazzi, GE; Heijnen, BF; Janssen, BJ; Mullins, JJ; Nelissen, J; Peutz-Kootstra, CJ; Schalkwijk, CG; Struijker-Boudier, HA; van Essen, H | 1 |
Hashimoto, T; Kitazato, KT; Kudo, M; Liang, EI; Makino, H; Murakami, S; Nagahiro, S; Shimada, K; Tada, Y; Wada, K | 1 |
Dopona, EP; Furukawa, LN; Heimann, JC; Katayama, IA; Oliveira, IB; Pereira, RC; Shimizu, MH | 1 |
Chishaki, A; Hirooka, Y; Inoue, S; Kishi, T; Mukai, Y; Nagayama, T; Sunagawa, K; Takase, S; Takemoto, M | 1 |
Arruda-Junior, DF; Girardi, AC; Virgulino, SG | 1 |
Adhikari, S; Alpert, L; Bissonnette, M; Chen, L; Deb, DK; Dougherty, U; Hart, J; He, L; Kwon, J; Li, YC; Liu, SQ; Liu, T; Liu, W; Pekow, J; Rubin, DT; Shi, Y; Wang, J; Zhao, Q; Zhou, G | 1 |
De Mey, JG; Janssen, B; Lemkens, P; Meens, MJ; Nelissen, J; Peters, SL; Schiffers, PM; Spijkers, LJ | 1 |
Höcherl, K; Thurner, LR | 1 |
Reviews
1 review(s) available for hydralazine and losartan
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Other Studies
65 other study(ies) available for hydralazine and losartan
Article | Year |
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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Cyclosporine; Enalapril; Furosemide; Hydralazine; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Microscopy, Electron, Scanning; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles | 1995 |
Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.
Topics: Actins; Angiotensin II; Animals; Base Sequence; Biphenyl Compounds; Blood Pressure; Captopril; Cardiomegaly; DNA; DNA Primers; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Heart; Hydralazine; Hydroxyproline; Imidazoles; Isoproterenol; Labetalol; Losartan; Male; Methyldopa; Molecular Sequence Data; Myocardium; Myosins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrazoles; Transcription, Genetic | 1994 |
Modulation of renal vasoconstrictor effect of NG-nitro-L-arginine in rabbit by angiotensin II and alpha-1 adrenergic receptor blockade.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antibodies; Arginine; Biphenyl Compounds; Drug Interactions; Hemodynamics; Hydralazine; Imidazoles; Kidney; Losartan; Male; Nitroarginine; Prazosin; Rabbits; Tetrazoles; Vasoconstrictor Agents | 1994 |
Cardiac hypertrophy and brain natriuretic peptide in experimental hypertension.
Topics: Animals; Atrial Natriuretic Factor; Biphenyl Compounds; Blood Pressure; Blood Urea Nitrogen; Cardiomegaly; Chromatography, High Pressure Liquid; Creatinine; Desoxycorticosterone; Enalapril; Heart; Hydralazine; Hypertension, Malignant; Imidazoles; Losartan; Male; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Rats; Rats, Inbred SHR; Sodium, Dietary; Tetrazoles | 1994 |
Angiotensin II alters aortic fibronectin independently of hypertension.
Topics: Angiotensin II; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Fibronectins; Humans; Hydralazine; Hypertension; Imidazoles; Losartan; Male; Prazosin; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles | 1994 |
Alterations in vascular structure and function after short-term losartan treatment in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Hydralazine; Hypertension; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Tetrazoles; Vasoconstriction | 1993 |
Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Body Weight; Hematocrit; Hydralazine; Hypertension; Imidazoles; Infusions, Intravenous; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor I; Losartan; Male; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Reference Values; Tetrazoles; Time Factors; Vasodilator Agents; Weight Loss | 1996 |
Angiotensin II increases left ventricular mass without affecting myosin isoform mRNAs.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Heart Ventricles; Hemodynamics; Hydralazine; Hypertrophy, Left Ventricular; Imidazoles; Infusion Pumps, Implantable; Losartan; Male; Myosin Heavy Chains; Organ Size; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Tetrazoles | 1996 |
p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Experimental; Hydralazine; Imidazoles; In Situ Hybridization; Losartan; Male; Membrane Transport Proteins; NADPH Dehydrogenase; NADPH Oxidases; Phosphoproteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Systole; Tetrazoles | 1997 |
The renin angiotensin system and nociception in spontaneously hypertensive rats.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Captopril; Hydralazine; Hypertension; Imidazoles; Losartan; Male; Motor Activity; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Tetrazoles | 1995 |
Effects of quinapril, losartan and hydralazine on cardiac hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats.
Topics: Adenylyl Cyclases; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Blood Pressure; Cardiomegaly; GTP-Binding Proteins; Hydralazine; Isoquinolines; Losartan; Myocardium; Neuropeptides; Organ Size; Quinapril; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Tetrahydroisoquinolines; Vasodilator Agents | 1998 |
The influence of restraint on blood pressure in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Captopril; Heart Rate; Hydralazine; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Restraint, Physical; Telemetry | 1997 |
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Apoptosis; Arginine; Biotin; Cyclosporine; Deoxyuracil Nucleotides; DNA Fragmentation; Enzyme Inhibitors; Fibrosis; Hydralazine; Immunosuppressive Agents; Ischemia; Kidney; Losartan; Macrophages; Male; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Staining and Labeling | 1998 |
Regulation of glomerular TGF-beta expression in the contralateral kidney of two-kidney, one-clip hypertensive rats.
Topics: Animals; Antihypertensive Agents; Drug Combinations; Hydralazine; Hydrochlorothiazide; Hypertension, Renovascular; Kidney; Kidney Glomerulus; Losartan; Male; Rats; Rats, Wistar; Reserpine; RNA, Messenger; Sclerosis; Time Factors; Transforming Growth Factor beta | 1998 |
Dissociation of blood pressure reduction from end-organ damage in TGR(mREN2)27 transgenic hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Carbazoles; Carvedilol; Heart Function Tests; Hydralazine; Hypertension; Isoquinolines; Losartan; Norepinephrine; Propanolamines; Quinapril; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrahydroisoquinolines | 1998 |
Angiotensin II receptors within the nucleus of the solitary tract mediate the developmental attenuation of the baroreceptor vagal reflex in pre-weaned rats.
Topics: Age Factors; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antihypertensive Agents; Blood Pressure; Halothane; Heart Rate; Hydralazine; Losartan; Male; Microinjections; Phenylephrine; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Reflex; Solitary Nucleus; Sympathomimetics; Urethane; Vagus Nerve; Weaning | 1998 |
Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiomegaly; Cell Nucleus; Diastole; DNA; Female; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Indoles; Losartan; Lymphocytes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Perindopril; Rats; Rats, Inbred SHR; Systole; Telemetry; Time Factors | 1999 |
Antihypertensive mechanisms underlying a novel salt-sensitive hypertensive model induced by sensory denervation.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blood Pressure; Body Weight; Calcitonin Gene-Related Peptide; Capsaicin; Diuresis; Ganglia, Spinal; Hydralazine; Hypertension; Losartan; Male; Nerve Degeneration; Neurons, Afferent; Potassium; Prazosin; Rats; Rats, Wistar; Sodium; Sodium, Dietary | 1999 |
Angiotensin II AT1-receptor blockade inhibits monocyte activation and adherence in transgenic (mRen2)27 rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Cell Count; Blood Pressure; Cell Adhesion; Endothelium, Vascular; Female; Heart Rate; Hematocrit; Hydralazine; Hypertension; Losartan; Male; Monocytes; Nitroblue Tetrazolium; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 1999 |
Apoptosis during regression of cardiac hypertrophy in spontaneously hypertensive rats. Temporal regulation and spatial heterogeneity.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Apoptosis; Calcium Channel Blockers; Cardiomegaly; Data Interpretation, Statistical; DNA; DNA Fragmentation; Enalapril; Hemodynamics; Hydralazine; Losartan; Male; Nifedipine; Propranolol; Rats; Time Factors | 1999 |
Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts.
Topics: Actinin; Age Factors; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antigens, CD; Antihypertensive Agents; Biphenyl Compounds; Cardiomegaly; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Collagen; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Heart Ventricles; Hydralazine; Imidazoles; Integrin alphaV; Integrin beta Chains; Integrin beta1; Integrin beta3; Integrins; Irbesartan; Laminin; Losartan; Myocardium; Phosphorylation; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Up-Regulation; Vitronectin | 2000 |
The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Drug Administration Schedule; Fosinopril; Hydralazine; Hypertension; Lipid Peroxidation; Lipoproteins, LDL; Losartan; Mice; Mice, Transgenic; Oxidation-Reduction; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 1999 |
Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats : possible role in renoprotection.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cell Line, Transformed; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Filtration Rate; Heart Rate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hydralazine; Hypertension; Immunohistochemistry; Kidney Tubules, Proximal; Losartan; Norepinephrine; Oxidative Stress; Proteinuria; Protoporphyrins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cell Division; Gene Expression Regulation, Enzymologic; Heart; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemodynamics; Hydralazine; Infusions, Intravenous; Kinetics; Losartan; Male; Myocardium; Norepinephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 2000 |
Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Enalapril; Furosemide; Guanylate Cyclase; Hydralazine; Losartan; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Myocardium; Organ Size; Propranolol; Receptors, Atrial Natriuretic Factor; Telemetry; Ventricular Dysfunction, Left | 2001 |
The influence of chronic antihypertensive treatment on the central pressor response in SHR.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Body Weight; Brain; Enalapril; Epinephrine; Heart Rate; Hydralazine; Hydrochlorothiazide; Hypertension; Injections, Intraventricular; Losartan; Male; Norepinephrine; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Saline Solution, Hypertonic; Tetrazoles | 2001 |
Persistent lowering of arterial pressure after continuous and intermittent therapy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Enalapril; Heart Rate; Heart Ventricles; Hydralazine; Hydrochlorothiazide; Hypertension; Losartan; Male; Nifedipine; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Vasodilator Agents | 2003 |
Brain nitric oxide synthase activity in spontaneously hypertensive rats during the development of hypertension.
Topics: Age Factors; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Brain; Enalapril; Hydralazine; Hypertension; Losartan; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Vasodilator Agents | 2003 |
Spironolactone prevents cardiac collagen proliferation after myocardial infarction in rats.
Topics: Animals; Cicatrix; Collagen; Hydralazine; Losartan; Male; Myocardial Infarction; Myocardium; Organ Size; Rats; Rats, Wistar; Spironolactone | 2003 |
Tight blood pressure control decreases apoptosis during renal damage.
Topics: Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; Cell Division; Drug Therapy, Combination; Hydralazine; Hydrochlorothiazide; Hypertension, Renal; Immunohistochemistry; Losartan; Male; Proteinuria; Quinapril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reserpine; Tetrahydroisoquinolines | 2004 |
Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodeling and matrix metalloproteinases in resistance arteries.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Blotting, Western; Collagen Type I; Elasticity; Elastin; Fibronectins; Hydralazine; Losartan; Male; Matrix Metalloproteinase 2; Mesenteric Artery, Superior; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Vascular Resistance | 2005 |
Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats.
Topics: Aging; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcitonin Gene-Related Peptide; Cell Count; Hydralazine; Hypertension; Immunohistochemistry; Losartan; Male; Mesenteric Arteries; Nerve Fibers; Neuropeptide Y; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Sympathetic Nervous System; Thiazepines; Vasodilator Agents | 2005 |
Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects.
Topics: Aging; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Coronary Vessels; Hydralazine; Hydrochlorothiazide; Hypertension; In Vitro Techniques; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride Symporter Inhibitors; Vasodilation; Vasodilator Agents | 2005 |
Role of angiotensin type-1 and angiotensin type-2 receptors in the expression of vascular integrins in angiotensin II-infused rats.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Vessels; Hydralazine; Hypertension; Infusion Pumps; Integrins; Losartan; Male; Osteopontin; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sialoglycoproteins; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
Impact of antihypertensive treatments on erectile responses in aging spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Apomorphine; Blood Pressure; Enalapril; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney Transplantation; Losartan; Male; Nifedipine; Penile Erection; Random Allocation; Rats; Rats, Inbred SHR; Testosterone | 2006 |
Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atherosclerosis; Cholesterol; Creatinine; Disease Models, Animal; Female; Hydralazine; Losartan; Mice; Mice, Inbred C57BL; Nephrectomy; Renal Insufficiency | 2006 |
Expression and localization of PDGF-B, PDGF-D, and PDGF receptor in the kidney of angiotensin II-infused rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Cell Proliferation; Gene Expression Regulation; Hydralazine; In Situ Hybridization; Iron; Kidney; Lipid Metabolism; Losartan; Lymphokines; Male; Norepinephrine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Vasoconstrictor Agents | 2006 |
Transient AT1 receptor-inhibition in prehypertensive spontaneously hypertensive rats results in maintained cardiac protection until advanced age.
Topics: Age Factors; Aging; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomegaly; Cardiovascular Diseases; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Heart Ventricles; Hydralazine; Hypertension; Kidney; Losartan; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasodilator Agents; Ventricular Function, Left | 2007 |
Antihypertensive and renal protective effects of renin-angiotensin system blockade in uremic rats treated with erythropoietin.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Disease Models, Animal; Drug Therapy, Combination; Erythropoietin; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Kidney Failure, Chronic; Losartan; Nephrectomy; Rats; Rats, Wistar; Recombinant Proteins; Renin-Angiotensin System; Reserpine; Time Factors; Uremia | 2006 |
Prevention of hypertension abrogates early inflammatory events in the retina of diabetic hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Diabetic Retinopathy; Drug Combinations; Eye Proteins; Hydralazine; Hydrochlorothiazide; Hypertension; Immunohistochemistry; Intercellular Adhesion Molecule-1; Losartan; Male; Microglia; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reserpine; Retina; Transcription Factor RelA | 2007 |
Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Blood Pressure; Body Weight; Disease Progression; Elasticity; Female; Hydralazine; Lipids; Losartan; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Vasoconstrictor Agents | 2007 |
Overexpression of angiotensinogen increases tubular apoptosis in diabetes.
Topics: Albuminuria; Angiotensinogen; Animals; Antihypertensive Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blood Glucose; Cell Line, Transformed; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hydralazine; Hypertension, Renal; Hypoglycemic Agents; Insulin; Kidney Tubules, Proximal; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Perindopril; Rats; Renin-Angiotensin System | 2008 |
Persistent hypertension and progressive renal injury induced by salt overload after short term nitric oxide inhibition.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Hydralazine; Hypertension; Immunohistochemistry; Immunosuppressive Agents; Kidney; Kidney Failure, Chronic; Losartan; Male; Mycophenolic Acid; Nitric Oxide; Rats; Rats, Wistar; Sodium Chloride, Dietary | 2007 |
Hypertension impairs postnatal vasculogenesis: role of antihypertensive agents.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Bone Marrow Cells; Cell Differentiation; Disease Models, Animal; Endothelium, Vascular; Hindlimb; Hydralazine; Hypertension; Ischemia; Ligation; Losartan; Male; Neovascularization, Physiologic; Oxidative Stress; Perindopril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stem Cells | 2008 |
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Desoxycorticosterone; Heart Ventricles; Humans; Hydralazine; Hydrochlorothiazide; Hypertension, Renal; Kidney; Losartan; Mice; Mineralocorticoid Receptor Antagonists; Nephrosclerosis; p38 Mitogen-Activated Protein Kinases; Rats; Renin; Reserpine; RNA, Messenger; Spironolactone | 2008 |
Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; Cysteine Proteinase Inhibitors; Drug Therapy, Combination; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydralazine; Hypertension; Kidney Medulla; Losartan; Male; Oligopeptides; Osmolar Concentration; Pericytes; Phosphorylation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Sodium; Urine; Valproic Acid | 2009 |
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin-1; Hydralazine; Hypertension, Malignant; Losartan; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Insufficiency | 2009 |
Losartan increases NO release in afferent arterioles during regression of L-NAME-induced renal damage.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterioles; Blood Pressure; Disease Models, Animal; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Hydralazine; Kidney; Kidney Diseases; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Vasoconstriction | 2010 |
Salt-induced cardiac hypertrophy and interstitial fibrosis are due to a blood pressure-independent mechanism in Wistar rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Collagen Type I; Collagen Type III; Disease Models, Animal; Drinking; Eating; Echocardiography; Fibrosis; Gene Expression; Heart Ventricles; Hydralazine; Hypertension; Losartan; Male; Myocardium; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Sodium; Sodium Chloride, Dietary; Transforming Growth Factor beta; Urine | 2010 |
Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Collagen; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Hydralazine; Hypertension; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Losartan; Macrophages; Male; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System | 2011 |
Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood Vessels; Carotid Arteries; Ceramides; Endothelium, Vascular; Group VI Phospholipases A2; Hydralazine; In Vitro Techniques; Losartan; Male; Rats; Rats, Inbred SHR; Sphingolipids; Sphingomyelin Phosphodiesterase; Vasoconstriction | 2011 |
Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterial Pressure; Biomarkers; Blood Vessels; Case-Control Studies; Cell Adhesion Molecules; Cell Line; Disease Models, Animal; Humans; Hydralazine; Hypertension; Hypertension, Renovascular; Losartan; Male; Morpholinos; Prehypertension; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cell Surface; RNA, Messenger; Time Factors; Up-Regulation; Vasodilator Agents | 2012 |
Irreversible renal damage after transient renin-angiotensin system stimulation: involvement of an AT1-receptor mediated immune response.
Topics: Animals; Biomarkers; Hemodynamics; Hydralazine; Hypertension; Kidney; Losartan; Rats; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; T-Lymphocytes; Time Factors | 2013 |
Roles of hypertension in the rupture of intracranial aneurysms.
Topics: Aneurysm, Ruptured; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Desoxycorticosterone Acetate; Dose-Response Relationship, Drug; Hydralazine; Hypertension; Intracranial Aneurysm; Losartan; Male; Mice; Mice, Inbred C57BL; Pancreatic Elastase; Renin-Angiotensin System; Risk Factors; Subarachnoid Hemorrhage; Survival Analysis; Treatment Outcome | 2014 |
High-salt intake induces cardiomyocyte hypertrophy in rats in response to local angiotensin II type 1 receptor activation.
Topics: Acetylcysteine; Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Heart Rate; Hematocrit; Hydralazine; Losartan; Male; Myocytes, Cardiac; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Sodium; Sodium Chloride, Dietary; Thiobarbituric Acid Reactive Substances | 2014 |
Blockade of brain angiotensin II type 1 receptor inhibits the development of atrial fibrillation in hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Biomarkers; Blood Pressure; Brain; Disease Models, Animal; Echocardiography; Electrocardiography; Hydralazine; Hypertension; Infusions, Intraventricular; Losartan; Male; Norepinephrine; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Sympathetic Nervous System; Time Factors | 2015 |
Reduced tubular proteinuria in hypertensive rats treated with losartan is associated with higher renal cortical megalin expression.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Glomerular Filtration Barrier; Hydralazine; Kidney Cortex; Losartan; Low Density Lipoprotein Receptor-Related Protein-2; Male; Proteinuria; Rats, Inbred SHR; Receptors, Cell Surface | 2014 |
Activation of the Renin-Angiotensin System Promotes Colitis Development.
Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Colitis; Colon; Epithelial Cells; Fumarates; Humans; Hydralazine; Inflammatory Bowel Diseases; Losartan; Mice; Mice, Transgenic; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Th17 Cells | 2016 |
Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzazepines; Bosentan; Endothelin-Converting Enzymes; Endothelium, Vascular; Enzyme Inhibitors; Hydralazine; Hypertension; Losartan; Mesenteric Arteries; Muscle Contraction; Neprilysin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Protease Inhibitors; Rats; Rats, Inbred SHR; Sulfonamides; Vascular Resistance | 2017 |
Role of protease-activated receptor 2 in regulation of renin synthesis and secretion in mice.
Topics: Animals; Dose-Response Relationship, Drug; Furosemide; Gene Expression; Hydralazine; Isoproterenol; Kidney; Lipopolysaccharides; Losartan; Male; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Receptor, PAR-2; Renin; Sodium Chloride | 2019 |