hydralazine and indomethacin

hydralazine has been researched along with indomethacin in 44 studies

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (61.36)	18.7374
1990's	8 (18.18)	18.2507
2000's	5 (11.36)	29.6817
2010's	4 (9.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Campbell, WB; Graham, RM; Jackson, EK	2
Ahnfelt-Rønne, I; Arrigoni-Martelli, E	1
Gerold, M; Haeusler, G	1
Cangiano, JL; Martinez-Maldonado, M; Rodriguez-Sargent, C	1
Hart, M; Stone, KJ	1
Kadowaki, H; Miyagawa, I; Nakamura, I; Okazaki, T; Saeki, H; Shimamoto, T; Sofikitis, N; Takahashi, C	1
Beckmann, ML; Byyny, RL; Gerber, JG; Loverde, M; Nies, AS	1
Clozel, M; Hefti, F; Kuhn, H	1
Raij, L; Shultz, PJ	1
Ksander, GM; Levens, NR; Mullane, KM; Zimmerman, MB	1
Friedman, WF; George, BL	1
Baez, A; Kaley, G; Panzenbeck, M	1
Bartels, T; Beitz, J; Heinemann, S; Hoffmann, P; Taube, C	1
Kageyama, M; Matsumura, Y; Morimoto, S; Sasaki, Y; Takakuwa, T	1
Adnot, S; Brun-Buisson, C; de Cremoux, H; Defouilloy, C; Lemaire, F; Piquet, J	1
Cinquegrani, MP; Liang, CS	1
Garcia-Marquez, F; Vidrio, H	1
Graeme, ML; John, M; Sigg, EB	1
Kadowitz, PJ; Krishnamurty, VS	1
Sinaiko, AR	1
Cornwell, DG; Lindsey, JA; Milo, GE; Morisaki, N	1
Jackson, SH; Pickles, H	1
Chen, BT; Kawashima, S; Liang, CS; Maekawa, K; Tsui, A	1
Jones, GR	1
Campbell, WB; Graham, RM; Jackson, EK; Loisel, DP; Pettinger, WA	1
Bambach, D; Fontana, ME; Hermiller, JB; Huss, P; Leier, CV; Magorien, RD; Thompson, MJ; Unverferth, DV	1
Jones, DH; Reid, JL	1
Lazar, JD; Rubin, LJ	1
Gross, F; Khayyal, M; Kreye, VA	1
al-Bekairi, AM; al-Rajhi, AM; Tariq, M	1
Goto, K; Kasuya, Y; Kimura, S; Masaki, T; Wei, S; Yanagisawa, M	1
Anderson, IK; Drew, GM	1
Chambers, TJ; Chow, JW; Fox, SW; Lean, JM	1
Bakhtiarian, A; Djahanguiri, B; Rahgozar, M; Toroudi, HP	1
Abe, Y; Chen, QH; Kosaka, H; Tian, RX; Yamamoto, A; Yoneyama, H; Zhang, L; Zhou, MS	1
Gorny, D; Henrion, D; Kubis, N; Lévy, BI; Loufrani, L	1

Reviews

1 review(s) available for hydralazine and indomethacin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for hydralazine and indomethacin

Article	Year
Hydralazine does not stimulate prostacyclin biosynthesis in hypertensive patients. The American journal of the medical sciences, 1990, Volume: 299, Issue:3 Topics: Adult; Aged; Blood Pressure; Drug Interactions; Epoprostenol; Female; Humans; Hydralazine; Hypertension; Indomethacin; Male; Middle Aged	1990
Indomethacin attenuates the hypotensive action of hydralazine. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:5 Topics: Adult; Analysis of Variance; Blood Pressure; Double-Blind Method; Drug Interactions; Epinephrine; Female; Forearm; Glomerular Filtration Rate; Heart Rate; Humans; Hydralazine; Indomethacin; Infusions, Parenteral; Male; Norepinephrine; Random Allocation; Renal Circulation; Vascular Resistance	1986
Indomethacin does not attenuate the effects of hydralazine in normal subjects. European journal of clinical pharmacology, 1983, Volume: 25, Issue:3 Topics: Adult; Blood Pressure; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Hydralazine; Indomethacin; Male	1983
Volume expansion and vasodilators in the treatment of idiopathic postural hypotension. Postgraduate medical journal, 1980, Volume: 56, Issue:654 Topics: Aged; Fludrocortisone; Humans; Hydralazine; Hypotension, Orthostatic; Indomethacin; Male; Sodium	1980

Other Studies

39 other study(ies) available for hydralazine and indomethacin

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Role of renal prostaglandins in sympathetically mediated renin relase in the rat. The Journal of clinical investigation, 1979, Volume: 64, Issue:2 Topics: Adrenergic beta-Agonists; Animals; Arachidonic Acids; Blood Pressure; Bucladesine; Chlorisondamine; Heart Rate; Hydralazine; Indomethacin; Isoproterenol; Kidney; Male; Meclofenamic Acid; Prostaglandin Antagonists; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Renin; Sympathetic Nervous System	1979
Rabbit lung microsomes: a rapid method for assaying simultaneously drug effects on thromboxane and prostacyclin synthesis. Agents and actions. Supplements, 1979, Issue:4 Topics: Animals; Arachidonic Acids; Aspirin; Burimamide; Dipyridamole; Epoprostenol; Hydralazine; Imidazoles; Indomethacin; Lung; Microsomes; Prostaglandins; Rabbits; Thromboxanes	1979
Increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine, dihydralazine and minoxidil. Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 310, Issue:2 Topics: Angiotensin II; Animals; Blood Pressure; Dihydralazine; Dogs; Female; Guinea Pigs; Hydralazine; Hypotension; Indomethacin; Male; Minoxidil; Prostaglandins; Pyrimidines; Rabbits; Species Specificity; Time Factors	1979
Modification of experimental renal hypertension in the rat by indomethacin and hydralazine. The Journal of laboratory and clinical medicine, 1978, Volume: 92, Issue:4 Topics: Animals; Disease Models, Animal; Female; Hydralazine; Hypertension, Renal; Indomethacin; Potassium; Rats; Renin; Sodium	1978
Inhibition of renal PGE2-9-ketoreductase by diuretics. Prostaglandins, 1976, Volume: 12, Issue:2 Topics: Alcohol Oxidoreductases; Animals; Chlorthalidone; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hydralazine; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Kidney Cortex; Phentolamine; Prostaglandins E; Rabbits; Rats; Thiazines	1976
Surgical repair versus medical treatment of varicocele in the rat: pharmacological manipulation of the varicocelized testicle. European urology, 1992, Volume: 22, Issue:1 Topics: Animals; Body Temperature; Chorionic Gonadotropin; Epididymis; Fertility; Hydralazine; Indomethacin; Infertility, Male; Kallikreins; Male; Organ Size; Prostate; Rats; Rats, Wistar; Sperm Count; Sperm Motility; Testis; Varicocele	1992
Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1990, Volume: 16, Issue:5 Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cilazapril; Endothelium, Vascular; Hydralazine; Hypertension; Indomethacin; Male; Pyridazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin	1990
Effects of antihypertensive agents on endothelium-dependent and endothelium-independent relaxations. British journal of clinical pharmacology, 1989, Volume: 28 Suppl 2 Topics: Acetylcholine; Adenosine Diphosphate; Administration, Oral; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Captopril; Enalapril; Hydralazine; Indomethacin; Male; Nitric Oxide; Pyrogallol; Rats; Rats, Inbred Strains	1989
Thromboxane synthase inhibition enhances action of converting enzyme inhibitors. Hypertension (Dallas, Tex. : 1979), 1989, Volume: 13, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Drug Synergism; Hydralazine; Indomethacin; Kidney; Phenylacetates; Pyridines; Rats; Rats, Inbred SHR; Sulfonamides; Thromboxane-A Synthase	1989
Treatment of cardiac failure in infants. Comprehensive therapy, 1986, Volume: 12, Issue:2 Topics: Alprostadil; Captopril; Digitalis Glycosides; Diuretics; Drug Therapy, Combination; Heart Failure; Humans; Hydralazine; Indomethacin; Infant; Infant, Newborn; Nitroglycerin; Nitroprusside	1986
Prostaglandins participate in the renal vasodilation due to hydralazine in dogs. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2 Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Dogs; Hydralazine; Indomethacin; Male; Prazosin; Prostaglandins; Renal Circulation; Vascular Resistance; Vasodilation	1986
Cardiovascular actions of dihydralazine as modified by dietary linoleic acid. Biomedica biochimica acta, 1986, Volume: 45, Issue:8 Topics: Animals; Aorta, Abdominal; Aspirin; Blood Pressure; Dietary Fats; Dihydralazine; Epoprostenol; Fatty Acids; Female; Hydralazine; In Vitro Techniques; Indomethacin; Kidney; Linoleic Acid; Linoleic Acids; Male; Phospholipids; Pregnancy; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Species Specificity	1986
Diuretic effect induced by intrarenal infusion of pinacidil in anesthetized dogs. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3 Topics: Anesthesia; Animals; Blood Pressure; Bradykinin; Diuretics; Dogs; Glomerular Filtration Rate; Guanidines; Hydralazine; Indomethacin; Kidney; Phosphates; Pinacidil; Renal Circulation; Sodium; Vasodilator Agents	1987
Effects of indomethacin on pulmonary hemodynamics and gas exchange in patients with pulmonary artery hypertension, interference with hydralazine. The American review of respiratory disease, 1987, Volume: 136, Issue:6 Topics: Aged; Cardiac Catheterization; Drug Evaluation; Drug Interactions; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Indomethacin; Lung Diseases, Obstructive; Male; Middle Aged; Pulmonary Circulation; Pulmonary Gas Exchange; Time Factors	1987
The influence of cyclo-oxygenase inhibitors on the cardiovascular effects of hydralazine in rats. Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 273, Issue:1 Topics: Animals; Aspirin; Blood Pressure; Body Temperature; Cyclooxygenase Inhibitors; Heart Rate; Hemodynamics; Hydralazine; Indomethacin; Male; Prostaglandins; Rats; Rats, Inbred Strains; Vasodilation	1985
Induction of periarthritis by oral administration of 6-sulfanilamidoindazole and its treatment in rats. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 157, Issue:1 Topics: Animals; Aspirin; Chloroquine; Cloxacillin; Hydralazine; Hydrocortisone; Indomethacin; Male; Mercaptopurine; Methotrexate; Morphine; ortho-Aminobenzoates; Oxyphenbutazone; Paramethasone; Periarthritis; Phenylbutazone; Rats; Sulfinpyrazone; Sulfonamides	1967
Influence of adenosine triphosphate on the isolated perfused mesenteric artery of the rabbit. Canadian journal of physiology and pharmacology, 1983, Volume: 61, Issue:11 Topics: Adenosine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Female; Hydralazine; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Muscle Tonus; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Rabbits; Reserpine; Vasodilation	1983
Influence of adrenergic nervous and prostaglandin systems on hydralazine-induced renin release. Life sciences, 1983, Dec-05, Volume: 33, Issue:23 Topics: Animals; Blood Pressure; Heart Rate; Hydralazine; Indomethacin; Male; Propranolol; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Renin	1983
Fatty acid metabolism and cell proliferation. III. Effect of prostaglandin biosynthesis either from exogenous fatty acid or endogenous fatty acid release with hydralazine. Lipids, 1983, Volume: 18, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Cell Division; Cells, Cultured; Dinoprostone; Fatty Acids; Guinea Pigs; Hydralazine; Indomethacin; Male; Muscle, Smooth, Vascular; Prostaglandins; Prostaglandins E	1983
Vasodilative effect of hydralazine in awake dogs: the roles of prostaglandins and the sympathetic nervous system. Circulation, 1984, Volume: 70, Issue:5 Topics: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Heart Rate; Hemodynamics; Hydralazine; Indomethacin; Oxygen Consumption; Phentolamine; Propranolol; Prostaglandins; Sympathetic Nervous System; Vascular Resistance; Vasodilator Agents	1984
Prevention of drug-induced upset to energy production in the S180 sarcoma by inhibition of prostaglandin synthetase [proceedings]. Biochemical Society transactions, 1980, Volume: 8, Issue:1 Topics: Adenine Nucleotides; Animals; Cyclooxygenase Inhibitors; Endotoxins; Energy Metabolism; Hydralazine; Indomethacin; Isoproterenol; Mice; Sarcoma 180; Tetradecanoylphorbol Acetate	1980
Inhibition of hydralazine-induced renin release by indomethacin in the rat. Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 246, Issue:2 Topics: Animals; Hemodynamics; Hydralazine; Indomethacin; Male; Propranolol; Prostaglandins E; Rats; Renin	1980
Effect of indomethacin on hydralazine-induced renin and catecholamine release in the conscious rabbit. British journal of pharmacology, 1980, Volume: 71, Issue:2 Topics: Animals; Catecholamines; Drug Interactions; Female; Heart Rate; Hydralazine; Indomethacin; Male; Rabbits; Renin	1980
Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension. Annals of internal medicine, 1982, Volume: 97, Issue:4 Topics: Adolescent; Adult; Aspirin; Diazoxide; Dipyridamole; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Indomethacin; Isoproterenol; Isosorbide Dinitrate; Middle Aged; Phentolamine; Prostaglandin Antagonists; Tolazoline; Vascular Resistance; Vasodilator Agents	1982
Influence of prostaglandin synthesis inhibitors on pulmonary vasodilatory effects of hydralazine in dogs with hypoxic pulmonary vasoconstriction. The Journal of clinical investigation, 1981, Volume: 67, Issue:1 Topics: Animals; Blood Pressure; Dogs; Female; Hydralazine; Indomethacin; Male; Meclofenamic Acid; ortho-Aminobenzoates; Oxygen; Prostaglandins; Pulmonary Artery; Respiration; Vascular Resistance; Vasodilation	1981
Studies on the direct vasodilator effect of hydralazine in the isolated rabbit renal artery. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 216, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Female; Hydralazine; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth; Norepinephrine; Ouabain; Potassium; Rabbits; Renal Artery; Sulpiride; Vasomotor System	1981
Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats. Pharmacological research, 1994, Volume: 29, Issue:3 Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucins; Hydralazine; Indomethacin; Male; Rats; Rats, Wistar; Reserpine; Stomach Ulcer; Stress, Physiological; Verapamil	1994
Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery. European journal of pharmacology, 1997, Mar-05, Volume: 321, Issue:3 Topics: Animals; Coronary Vessels; Cyclic AMP; Cyclic GMP; Cyclooxygenase Inhibitors; Dactinomycin; Endothelium; Hemoglobins; Hydralazine; In Vitro Techniques; Indomethacin; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Protein Synthesis Inhibitors; Swine; Vasodilator Agents	1997
Investigation of the inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antihypertensive effect of the angiotensin AT1 receptor antagonist, GR138950. British journal of pharmacology, 1997, Volume: 122, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Benzofurans; Blood Pressure; Cyclic GMP; Drug Interactions; Enalapril; Enzyme Inhibitors; Hydralazine; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase Inhibitors; Purinones; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin	1997
Role of nitric oxide and prostaglandins in mechanically induced bone formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998, Volume: 13, Issue:6 Topics: Animals; Blotting, Northern; Bone Development; Coccyx; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Genes, fos; Glutathione; Hydralazine; Indomethacin; Nitric Oxide; Nitroso Compounds; omega-N-Methylarginine; Penicillamine; Prostaglandins; Rats; Rats, Wistar; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Vasodilator Agents; Weight-Bearing	1998
Potassium channel modulators and indomethacin-induced gastric ulceration in rats. Scandinavian journal of gastroenterology, 1999, Volume: 34, Issue:10 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diazoxide; Enalapril; Gastric Mucosa; Glyburide; Hydralazine; Indomethacin; Male; Peptic Ulcer; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents	1999
L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats. Journal of hypertension, 2001, Volume: 19, Issue:3 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arginine; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclic GMP; Endothelins; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydralazine; Hydrazines; Hypertension; In Vitro Techniques; Indomethacin; Male; Methacrylates; Natriuresis; Nitrates; Nitrites; Nitroprusside; Rats; Rats, Inbred Dahl; Renal Artery; Thromboxane A2; Vasoconstriction	2001
Chronic hydralazine improves flow (shear stress)-induced endothelium-dependent dilation in mouse mesenteric resistance arteries in vitro. Microvascular research, 2002, Volume: 64, Issue:1 Topics: Acetylcholine; Animals; Blood Flow Velocity; Body Weight; Cardiovascular Agents; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hydralazine; Indomethacin; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Pressure; Stress, Mechanical; Vasodilator Agents	2002