hydralazine and amlodipine

hydralazine has been researched along with amlodipine in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (13.04)18.2507
2000's9 (39.13)29.6817
2010's8 (34.78)24.3611
2020's3 (13.04)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Atherley, R; Carlsen, RC; Gray, SD1
Bennett, MA; Hillier, C; Thurston, H1
Struthers, AD1
Chiou, SY; Lai, GW; Lin, G; Lin, LY1
Ito, T; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Ogawa, H; Tanaka, T; Tokutomi, Y; Yamamoto, E; Yamashita, T1
Aoyama, T; Esaki, M; Fujiwara, H; Fujiwara, T; Kanamori, H; Kawasaki, M; Maruyama, R; Minatoguchi, S; Miyata, S; Nakagawa, M; Ogino, A; Okada, H; Takemura, G; Ushikoshi, H1
Christian, R; Colon, PJ; Cushman, WC; Einhorn, PT; Ford, CE; Goff, DC; Henriquez, MA; Margolis, KL; Piller, LB; Vidt, DG; Wong, ND; Wright, JT1
Dong, YF; Ichijo, H; Kataoka, K; Kim-Mitsuyama, S; Matsuba, S; Ogawa, H; Shintaku, H; Tokutomi, Y; Yamamoto, E; Yamashita, T1
Aderibigbe, A; Anisiuba, BC; Ba, SA; Boombhi, HJ; Ijoma, CK; Kamdem, MK; Kaptue, J; Kingue, S; Kolo, PM; Lemogoum, D; M'buyamba-Kabangu, JR; Mipinda, JB; Ndiaye, MB; Odili, AN; Omotoso, BA; Richart, T; Staessen, JA; Thijs, L; Ulasi, II1
Bolen, MA; Halliburton, SS; Schoenhagen, P1
Baiswar, S; Suneja, M; Vogelgesang, SA1
Bidani, AK; Griffin, KA; Litbarg, N; Picken, M; Polichnowski, A; Venkatachalam, MA1
Cannon, L; Clark, D; Ming, DY; Moorthy, G; Reid, HW1
Biswas, A; Chen, X; Ghazi, L; Hanna, J; Li, F; Peixoto, AJ; Shah, T; Simonov, M; Wilson, FP; Yamamoto, Y1
Beeston, D; Cortellini, S; Jepson, R1

Reviews

2 review(s) available for hydralazine and amlodipine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Rationalizing the heart failure trials: from theory to practice.
    European heart journal, 1997, Volume: 18 Suppl E

    Topics: Adrenergic beta-Antagonists; Amiodarone; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Blood Pressure; Clinical Trials as Topic; Digoxin; Diuretics; Heart Failure; Humans; Hydralazine; Treatment Outcome; Vasodilator Agents

1997

Trials

2 trial(s) available for hydralazine and amlodipine

ArticleYear
Blood pressure control in Hispanics in the antihypertensive and lipid-lowering treatment to prevent heart attack trial.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:5

    Topics: Aged; Amlodipine; Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Canada; Chlorthalidone; Clonidine; Double-Blind Method; Doxazosin; Female; Heart Diseases; Hispanic or Latino; Humans; Hydralazine; Hypertension; Hypolipidemic Agents; Lisinopril; Male; Middle Aged; Puerto Rico; Reserpine; Treatment Outcome; United States; United States Virgin Islands; White People

2007
Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial.
    Blood pressure, 2011, Volume: 20, Issue:5

    Topics: Adult; Africa South of the Sahara; Aged; Amlodipine; Antihypertensive Agents; Bisoprolol; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Diuretics; Drug Combinations; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Research Design; Risk Factors; Tetrazoles; Valine; Valsartan

2011

Other Studies

19 other study(ies) available for hydralazine and amlodipine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Effect of chronic blood pressure reduction on soleus muscle contractile properties in spontaneously hypertensive rats.
    The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 2

    Topics: Amlodipine; Animals; Blood Pressure; Hindlimb; Hydralazine; Male; Muscle Contraction; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasodilator Agents

1994
Endothelium-dependent relaxation in resistance arteries from spontaneously hypertensive rats: effect of long-term treatment with perindopril, quinapril, hydralazine or amlodipine.
    Journal of hypertension, 1996, Volume: 14, Issue:3

    Topics: Acetylcholine; Amlodipine; Animals; Antihypertensive Agents; Arginine; Bradykinin; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydralazine; Hypertension; Indoles; Isoquinolines; Mesenteric Arteries; Nitroarginine; Perindopril; Quinapril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrahydroisoquinolines; Vasodilation

1996
Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro.
    Indian journal of biochemistry & biophysics, 2006, Volume: 43, Issue:1

    Topics: Amlodipine; Cardiovascular Agents; Enzyme Inhibitors; Hydralazine; Kinetics; Nifedipine; Octoxynol; Simvastatin; Sterol Esterase; Taurocholic Acid

2006
Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis.
    Journal of hypertension, 2006, Volume: 24, Issue:10

    Topics: Amlodipine; Animals; Azetidinecarboxylic Acid; Cardiomegaly; Dihydropyridines; Endomyocardial Fibrosis; Hydralazine; Hypertension; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tachycardia; Ventricular Remodeling

2006
Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:4

    Topics: Amlodipine; Animals; Apoptosis; bcl-Associated Death Protein; Calcineurin; Calcineurin Inhibitors; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Coronary Vessels; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; fas Receptor; Granulation Tissue; Hydralazine; Ligation; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Phosphorylation; Research Design; Tacrolimus; Time Factors; Vasodilator Agents; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2007
Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:12

    Topics: Acetophenones; Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; Biopterins; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Endothelium, Vascular; Heart Failure, Diastolic; Hydralazine; Hypertension; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Signal Transduction; Sodium Chloride, Dietary; Superoxides; Tetrazoles; Time Factors; Valine; Valsartan; Vasodilation

2007
Iterative CT reconstruction of aortic intramural hematoma.
    Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:7

    Topics: Amlodipine; Aortic Aneurysm; Aortic Dissection; Captopril; Drug Therapy, Combination; Female; Hematoma; Humans; Hydralazine; Metoprolol; Middle Aged; Multidetector Computed Tomography; Simvastatin; Treatment Outcome

2011
Hydralazine associated pauci-immune glomerulonephritis.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2014, Volume: 20, Issue:2

    Topics: Aged; Aged, 80 and over; Amlodipine; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Antihypertensive Agents; Biopsy; Female; Glomerulonephritis; Humans; Hydralazine; Hypertension; Kidney; Middle Aged; Treatment Outcome; Withholding Treatment

2014
Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:4

    Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Enalapril; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Nephrosclerosis; Rats; Rats, Inbred SHR; Reference Values; Treatment Outcome

2014
A Big Headache: An Unusual Case of Hypertensive Urgency in an Adolescent.
    Clinical pediatrics, 2021, Volume: 60, Issue:9-10

    Topics: Adolescent; Amlodipine; Antihypertensive Agents; Aorta, Abdominal; Aortic Valve Stenosis; Computed Tomography Angiography; Diagnosis, Differential; Female; Glucocorticoids; Headache; Humans; Hydralazine; Hypertension; Magnetic Resonance Angiography; Methylprednisolone; Takayasu Arteritis

2021
Blood pressure response to commonly administered antihypertensives for severe inpatient hypertension.
    PloS one, 2022, Volume: 17, Issue:4

    Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Pressure; Carvedilol; Cohort Studies; Humans; Hydralazine; Hypertension; Inpatients; Metoprolol

2022
Evaluation of presentation, treatment and outcome in hypertensive emergency in dogs and cats: 15 cases (2003-2019).
    The Journal of small animal practice, 2022, Volume: 63, Issue:10

    Topics: Amlodipine; Animals; Antihypertensive Agents; Blindness; Cat Diseases; Cats; Dog Diseases; Dogs; Emergencies; Humans; Hydralazine; Hypertension; Retrospective Studies; Seizures; Treatment Outcome

2022