hydralazine and acrolein

hydralazine has been researched along with acrolein in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	14 (53.85)	29.6817
2010's	8 (30.77)	24.3611
2020's	4 (15.38)	2.80

Authors

Authors	Studies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Burcham, PC; Fontaine, F; Kerr, PG	1
Burcham, PC; Fontaine, FR; Kaminskas, LM; Petersen, DR; Pyke, SM	2
Burcham, PC; Kaminskas, LM; Pyke, SM	2
Burcham, PC; Pyke, SM	1
Borgens, RB; Liu-Snyder, P; Shi, R	1
Barber, DS; Das, S; Gavin, T; Geohagen, BC; He, D; Lopachin, RM	1
Burcham, PC; Raso, A; Tan, D; Thompson, C	1
Duerstock, B; Hamann, K; Nehrt, G; Ouyang, H; Shi, R	1
Burcham, PC; Kaminskas, LM; Pyke, SM; Tan, D	1
Borgens, RB; Cho, Y; Ivanisevic, A; Shi, R	1
Hamann, K; Shi, R	1
Brookes, S; Leung, G; Shi, R; Sun, W; Tully, M; Zheng, L	1
Chen, F; Jiang, Y; Sun, Z; Wang, M; Zhu, Q	1
Burcham, PC; Kaminskas, LM; Raso, A	1
Allette, YM; Due, MR; Park, J; Shi, R; Walls, M; White, FA; Zheng, L	1
Duerstock, B; Marquis, A; Ouyang, Z; Park, J; Pond, A; Shi, R; Vega-Alvarez, S; Walls, M; Wang, H; Zheng, L	1
Acosta, G; Cao, P; Chen, Z; Muratori, B; Park, J; Shi, R; Vega-Alvarez, S; Zheng, L	1
Barker, DF; Barve, SS; Chen, WY; Donde, H; Ghare, SS; Gobejishvilli, L; Joshi-Barve, S; McClain, CJ	1
Tian, GX; Wu, YT; Xia, CQ; Yao, L; Zhang, F; Zhang, W	1
Gardeen, SS; Herr, SA; Low, PS; Shi, R	1
Chang, YP; Cheng, HW; Kuo, CW; Lin, CC; Liu, WS; Lu, SH; Tong, ZJ; Tsai, MT; Tsou, HH; Wang, HT; Yen, PC	1
Fan, Z; Qi, C; Quan, X; Wang, X; Wu, S; Wu, T; Yu, C; Zhang, H	1
Guo, K; Ma, T; Qi, CC; Quan, X; Song, BQ; Wang, H; Yu, CY	1

Reviews

4 review(s) available for hydralazine and acrolein

Article	Year
Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products. Toxicology, 2002, Dec-27, Volume: 181-182 Topics: Acrolein; Aldehydes; Animals; Carnosine; Guanidines; Humans; Hydralazine; Lipid Peroxidation; Oxidation-Reduction; Proteins; Pyridoxamine	2002
Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury. Mini reviews in medicinal chemistry, 2008, Volume: 8, Issue:4 Topics: Acrolein; Alzheimer Disease; Animals; Atherosclerosis; Cell Death; Free Radical Scavengers; Humans; Hydralazine; Liver Diseases, Alcoholic; Oxidative Stress; Protective Agents; Spinal Cord Injuries	2008
Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury. Journal of neurochemistry, 2009, Volume: 111, Issue:6 Topics: Acrolein; Animals; Free Radical Scavengers; Humans; Hydralazine; Lipid Peroxidation; Models, Biological; Oxidative Stress; Spinal Cord Injuries	2009
Acrolein scavengers: reactivity, mechanism and impact on health. Molecular nutrition & food research, 2011, Volume: 55, Issue:9 Topics: Acrolein; Ascorbic Acid; Drug Design; Glutathione; Humans; Hydralazine; Nitrogen Compounds; Oxidative Stress; Pharmaceutical Preparations; Polyphenols; Signal Transduction	2011

Other Studies

22 other study(ies) available for hydralazine and acrolein

Article	Year
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
The antihypertensive hydralazine is an efficient scavenger of acrolein. Redox report : communications in free radical research, 2000, Volume: 5, Issue:1 Topics: Acrolein; Animals; Antihypertensive Agents; Cell Death; Free Radical Scavengers; Hepatocytes; Hydralazine; Male; Mice	2000
Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity. Molecular pharmacology, 2004, Volume: 65, Issue:3 Topics: Acrolein; Animals; Antihypertensive Agents; Cells, Cultured; Cytoprotection; Drug-Related Side Effects and Adverse Reactions; Hepatocytes; Hydralazine; Mice; Protective Agents; Proteins	2004
Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3 Topics: Acrolein; Animals; Blotting, Western; Dose-Response Relationship, Drug; Glutathione; Hydralazine; Liver; Male; Mice; Propanols; Protective Agents	2004
Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde. Organic & biomolecular chemistry, 2004, Sep-21, Volume: 2, Issue:18 Topics: Acrolein; Aldehydes; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Hepatocytes; Hydralazine; Kinetics; Lipid Peroxidation; Mice; Molecular Structure	2004
Hydralazine inhibits rapid acrolein-induced protein oligomerization: role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection. Molecular pharmacology, 2006, Volume: 69, Issue:3 Topics: Acrolein; Aldehydes; Animals; Carnosine; Cross-Linking Reagents; Cytoprotection; Glutathione; Hepatocytes; Hydralazine; Mice; Protective Agents; Proteins	2006
Hydralazine rescues PC12 cells from acrolein-mediated death. Journal of neuroscience research, 2006, Volume: 84, Issue:1 Topics: Acrolein; Adenosine Triphosphate; Analysis of Variance; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Flow Cytometry; Glutathione; Hydralazine; L-Lactate Dehydrogenase; Neuroprotective Agents; PC12 Cells; Rats; Tetrazolium Salts; Thiazoles	2006
Structure-toxicity analysis of type-2 alkenes: in vitro neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 95, Issue:1 Topics: Acrolein; Acrylamide; Acrylates; Aldehydes; Alkenes; Allyl Compounds; Animals; Blotting, Western; Brain; Butanones; Cross-Linking Reagents; Dopamine; Dose-Response Relationship, Drug; Ethylmaleimide; Hydralazine; In Vitro Techniques; Male; Membrane Fusion Proteins; Neurons; Propanols; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfhydryl Reagents; Synaptic Vesicles; Synaptosomes; Tandem Mass Spectrometry	2007
Intermolecular protein cross-linking during acrolein toxicity: efficacy of carbonyl scavengers as inhibitors of heat shock protein-90 cross-linking in A549 cells. Chemical research in toxicology, 2007, Volume: 20, Issue:11 Topics: Acrolein; Adenosine Triphosphate; Blotting, Western; Cell Line, Tumor; Cross-Linking Reagents; Cytoprotection; HSP90 Heat-Shock Proteins; Humans; Hydralazine; Lung; Mass Spectrometry; Protein Carbonylation; Sulfites	2007
Hydralazine inhibits compression and acrolein-mediated injuries in ex vivo spinal cord. Journal of neurochemistry, 2008, Volume: 104, Issue:3 Topics: Acrolein; Analysis of Variance; Animals; Antihypertensive Agents; Dextrans; Drug Interactions; Glutathione; Guinea Pigs; Hydralazine; In Vitro Techniques; L-Lactate Dehydrogenase; Neural Conduction; Rhodamines; Spinal Cord Injuries; Superoxides; Tetrazolium Salts; Thiazoles	2008
Functionalized mesoporous silica nanoparticle-based drug delivery system to rescue acrolein-mediated cell death. Nanomedicine (London, England), 2008, Volume: 3, Issue:4 Topics: Acrolein; Animals; Cell Membrane; Cell Survival; Drug Delivery Systems; Endocytosis; Hydralazine; Microscopy, Electron, Transmission; Nanoparticles; Nanotechnology; PC12 Cells; Polyethylene Glycols; Porosity; Rats; Silicon Dioxide	2008
Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse. Neuroscience, 2011, Jan-26, Volume: 173 Topics: Acrolein; Animals; Antioxidants; Behavior, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Fluorescent Antibody Technique; Hydralazine; Immunoblotting; Mice; Mice, Inbred C57BL; Myelin Sheath; Spinal Cord	2011
Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress. Molecular pharmacology, 2012, Volume: 82, Issue:5 Topics: Acrolein; Adenosine Triphosphate; Antioxidants; Cell Line, Tumor; Cell Survival; Cytoprotection; Heat-Shock Response; HSP90 Heat-Shock Proteins; Humans; Hydralazine; Intermediate Filaments; Oxidative Stress; Protein Carbonylation	2012
Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat. Journal of neurochemistry, 2014, Volume: 128, Issue:5 Topics: Acrolein; Animals; Behavior, Animal; Blotting, Western; Cold Temperature; DNA, Complementary; Electrophysiological Phenomena; Ganglia, Sensory; Hot Temperature; Hydralazine; Inflammation; Injections, Spinal; Lipid Peroxidation; Male; Neuralgia; Nociceptors; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reflex, Abnormal; RNA; Spinal Cord Injuries; TRPA1 Cation Channel; TRPC Cation Channels	2014
Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage. Journal of neurochemistry, 2014, Volume: 129, Issue:2 Topics: Acrolein; Animals; Behavior, Animal; Blotting, Western; Contusions; Hydralazine; Locomotion; Male; Neuralgia; Neuroprotective Agents; Pain Measurement; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries	2014
Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury. Journal of neurochemistry, 2015, Volume: 135, Issue:5 Topics: Acetylcysteine; Acrolein; Animals; Disease Models, Animal; Ganglia, Spinal; Hydralazine; Hyperalgesia; Locomotion; Male; Neuralgia; Pain Threshold; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord; Spinal Cord Injuries; TRPA1 Cation Channel; TRPC Cation Channels; Up-Regulation; Vasodilator Agents	2015
Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicology in vitro : an international journal published in association with BIBRA, 2016, Volume: 35 Topics: Acrolein; Animals; Anti-HIV Agents; Apoptosis; Cell Survival; Cells, Cultured; DNA Fragmentation; Epigenesis, Genetic; Fas Ligand Protein; Hep G2 Cells; Hepatocytes; Histones; Humans; Hydralazine; Rats; RNA Polymerase II; Zidovudine	2016
Acrolein Scavenger Hydralazine Prevents Streptozotocin-Induced Painful Diabetic Neuropathy and Spinal Neuroinflammation in Rats. Anatomical record (Hoboken, N.J. : 2007), 2017, Volume: 300, Issue:10 Topics: Acrolein; Animals; Diabetic Nephropathies; Drug Evaluation, Preclinical; Hydralazine; Male; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Streptozocin; Vasodilator Agents	2017
Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation. Free radical biology & medicine, 2022, 05-01, Volume: 184 Topics: Acrolein; Animals; Folic Acid; Humans; Hydralazine; Lipid Peroxidation; Rats; Spinal Cord Injuries	2022
Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo. European journal of endocrinology, 2022, Oct-01, Volume: 187, Issue:4 Topics: Acetylcysteine; Acrolein; Animals; Carnosine; Cytokines; Diabetes Mellitus; Diabetic Nephropathies; Environmental Pollutants; HEK293 Cells; Humans; Hydralazine; Kidney; Mice; Streptozocin	2022
Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury. Experimental neurology, 2023, Volume: 363 Topics: Acrolein; Animals; Hydralazine; Macrophages; Male; Mice; Pain; Rats; Spinal Cord; Spinal Cord Injuries	2023
Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation. Current medical science, 2023, Volume: 43, Issue:4 Topics: Acrolein; Animals; Hydralazine; Inflammation; Macrophages; Mice; Neuralgia; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries	2023