Page last updated: 2024-08-21

hydantoins and azimilide

hydantoins has been researched along with azimilide in 129 studies

Research

Studies (129)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	37 (28.68)	18.2507
2000's	86 (66.67)	29.6817
2010's	6 (4.65)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baskin, EP; Fermini, B; Guinosso, PJ; Jow, B; Jurkiewicz, NK; Lynch, JJ; Salata, JJ	1
Black, SC; Butterfield, JL; Lucchesi, BR	1
Kane, KA; McIntosh, MA; Pacini, D; Tanira, M	1
Busch, AE; Herzer, T; Krippeit-Drews, P; Lang, F; Takumi, T; Waldegger, S	1
Adelman, JP; Busch, AE; Groh, WJ; Malloy, K; Maylie, J; Varnum, MD	1
Busch, AE; Herzer, T; Lang, F; Wagner, CA; Waldegger, S	1
Brooks, RR; Carpenter, JF; Maynard, AE; Miller, KE	1
Davies, MP; Freeman, LC; Kass, RS	1
Assadi, MA; Avitable, MJ; Brooks, RR; Caref, EB; el-Hamami, M; el-Sherif, N; Hegazy, M; Piracha, M; Restivo, M; Yin, H	1
Bleich, M; Busch, AE; Ecke, D; Greger, R; Kunzelmann, K; Lang, F; Lang, HJ; Rizzo, M; Suessbrich, H; Szabo, I; Waldegger, S	1
Brooks, RR; Drexler, AP; Micklas, JM	1
Fermini, B; Folander, K; Guinosso, PJ; Jow, B; Jurkiewicz, NK; Raynor, B; Salata, JJ; Swanson, R	1
Tseng, GN; Yao, JA	1
Gibson, KJ; Groh, WJ; Maylie, JG	1
Attali, B; Busch, AE; Busch, GL; Ford, E; Greger, R; Kunzelmann, K; Lang, HJ; Stühmer, W; Suessbrich, H	1
Benn, DR; Kostreva, DR; Lowe, ER; Maynard, AE; Mittelstadt, SW	1
Busch, AE; Eigenberger, B; Jurkiewicz, NK; Lang, F; Pica, A; Salata, JJ; Suessbrich, H	1
Agnew, J; Bao, J; Bryson, P; Comer, P; Corey, A; Griffith, S; Li, J	1
Baskin, EP; Lynch, JJ	1
Camm, AJ; Karam, R; Pratt, CM	1
Brooks, RR; Corey, AE; Karam, R; Marcello, S; Moore, A	1
Bril, A; Cheval, B; Faivre, JF; Forest, MC	1
Brooks, RR; Carpenter, JF; Miller, KE	1
Gintant, GA	1
Liu, L; Nattel, S; St-Georges, D	1
Bao, JJ; Parekh, NJ; Shuja, A	1
Sager, PT	2
Al-Khalidi, H; Brezovic, C; Corey, A; Karam, R; Marcello, S; Parekh, N; Taylor, K	1
Dorian, P; Newman, D; Qi, XQ	2
Chino, D; Hashimoto, K; Xue, Y; Yamada, C	1
Dun, W; Fan, JS; Jiang, M; Tseng, GN	1
Agnew, J; Brum, J; Corey, A; Parekh, N; Valentine, S; Williams, M	1
Agnew, JR; Corey, AE; Nesbitt, JD; Powell, JH; Thompson, GA; Valentine, SN; Wagner, DL	2
Al-Khalidi, H; Brooks, RR; Drexler, AP; Kostreva, DR; Maynard, AE	1
Clemett, D; Markham, A	1
Doggrell, SA; Nand, V	1
Brooks, RR; Finch, SL	1
Carnes, CA; Mehdirad, AA	1
Connolly, SJ; Marcello, SR; Page, RL; Pritchett, EL; Schnell, DJ; Wilkinson, WE	4
Boyden, PA; Cabo, C; Jiang, M; Tseng, G; Yao, J	1
Breit, SN; Bursill, JA; Campbell, TJ; Singleton, CB; Tie, H; Valenzuela, SM; Walker, BD; Wyse, KR	1
Abrol, R; Page, RL	1
Leunissen, JD; Van Opstal, JM; Vos, MA; Wellens, HJ	1
Camm, AJ	1
Kowey, PR; Liu, T; Marinchak, RA; Wang, J; Wu, Y; Yan, GX	1
Conway, DS; Lip, GY	1
Brooks, RR; Gopalakrishnan, M; Izzo, NJ; Moorehead, TJ; Pong, SF; Triggle, DJ	1
Assadi, MA; Brooks, RR; Caref, EB; El-Hamami, M; El-Sherif, N; Hegazy, M; Restivo, M; Yin, H	1
Cabo, C; Coromilas, JC; Schmitt, H; Wit, AL	1
Agnew, JR; Grasela, TH; Ludwig, EA; Phillips, L; Thompson, GA	1
SoRelle, R	1
Reiffel, JA	2
Bianconi, L; Castro, A; Santini, M	1
Connolly, SJ; Marcello, SR; Page, RL; Pritchett, EL; Schnell, D; Schulte, MC; Wilkinson, WE	1
Kobayashi, Y	1
Brendel, J; Busch, AE; Knobloch, K; Peukert, S; Rosenstein, B; Wirth, KJ	1
Grönefeld, GC; Hohnloser, SH	1
Agnew, JR; Corey, AE; Parekh, NJ; Powell, JH; Thompson, GA; Valentine, SN	1
Dorian, P; Dunnmon, P; Elstun, L; Newman, D	1
Chen, F; Esmailian, F; Klitzner, TS; Sarma, JS; Singh, BN; Sun, W; Wetzel, GT	1
Liu, YC; Wu, SN	1
Connolly, SJ; Marcello, SR; Page, RL; Pritchett, EL; Schnell, DJ; Tilsch, TW; Wilkinson, WE	1
Wolbrette, DL	1
Hara, M; Kanki, H; Kurita, Y; Mitamura, H; Ogawa, S; Sato, T; Shinagawa, K; Shiroshita-Takeshita, A; Takatsuki, S	1
Iost, N; Lengyel, C; Nesic, M; Papp, JG; Takács, J; Varró, A; Virág, L	1
Pratt, CM	1
Khan, MH	1
Al-Khalidi, H; Brum, J; Henthorn, R; Holroyde, M; Niazi, I; Simmons, T; Singer, I; Tchou, P	1
Li, WZ	1
Marcello, SR; Pritchett, EL	1
Singh, S	1
Al-Khalidi, HR; Brum, JM; Camm, AJ; Holroyde, MJ; Karam, R; Pratt, CM; Schwartz, PJ; Sonnenblick, EH; Spyt, MJ	1
Destefano, AJ; El Mouelhi, M; Kuzmak, B; Thompson, GA; Worley, DJ	2
Al-Khalidi, HR; Brum, JM; Camm, AJ; Holroyde, MJ; Marcello, SR; Pratt, CM; Schwartz, PJ; Singh, SN	1
Agnew, JR; Corey, AE; King, EC; Parekh, NJ; Powell, JH; Thompson, GA	1
Dong, DL; Du, ZM; Li, Z; Song, WH; Wang, HZ; Yang, BF	1
Furuichi, H; Hisatome, I; Hoshikawa, Y; Igawa, O; Iizuka, K; Kurata, Y; Makita, N; Manabe, K; Miake, J; Nanba, E; Narahashi, T; Ohgi, S; Sasaki, N; Shiota, G; Taniguchi, S; Yamamoto, Y; Yoshida, A	1
Bleich, M; Brendel, J; Busch, AE; Knobloch, K; Rosenstein, B; Wirth, KJ	1
Pürerfellner, H	1
Brendorp, B; Elming, H; Køber, L; Pedersen, OD; Pehrson, S; Torp-Petersen, C	1
Al-Khalidi, HR; Borggrefe, M; Brachmann, J; Brum, JM; Cannom, DS; Dorian, P; Hohnloser, SH; Holroyde, MJ; Myerburg, RJ; Pratt, CM; Singer, I; Tatla, DS; van der Laan, M	1
Hanna, IR; Langberg, JJ	1
Gerstenfeld, EP; Marchlinski, FE; Nayak, H; Patel, VV; Rajawat, YS	1
Al-Khalidi, HR; Borggrefe, M; Brachmann, J; Brum, JM; Cannom, DS; Dorian, P; Hohnloser, SH; Holroyde, MJ; Myerburg, RJ; Pratt, CM; Tatla, DS; van der Laan, M	1
Cvetanovic, I; Ke, X; Lin, C; Ranade, V; Somberg, J	2
Carlson, M	1
Cambron, RT; Hausman, DS; Sakr, A	1
Agnew, JR; Corey, AE; Moehrke, W; Parekh, N; Powell, JH; Thompson, GA; Toothaker, RD; Valentine, SN	1
Entwisle, JR; Figary, PC; Moorehead, TJ; Ohashi, N; Ohashi, R; Riley, P; Roe, AL; Thompson, GA	1
Ducouret, P; Ducroq, J; Gérard, JL; Puddu, PE; Rouet, R; Sallé, L; Tabourel, C	1
Carlsson, L; Kowey, PR; Liu, T; Wu, Y; Yan, GX	1
Houamed, K; Kupershmidt, S; Roden, D; Satin, LS; Zhang, M	1
Carlsson, L; Chartier, D; Nattel, S	1
Connolly, S; Kerr, C; Kowey, P; Page, RL; Pritchett, EL; Wilkinson, WE	1
Carlsson, L; Jacobson, I; Löfberg, L	1
Connolly, SJ; Kerr, CR; Kowey, P; Page, RL; Pritchett, EL; Ruda, MY; Ruzyllo, W; Wilkinson, WE	1
Al-Khalidi, HR; Borggrefe, M; Brum, JM; Camm, AJ; Dorian, P; Holroyde, MJ; Marcello, SR; Pratt, CM; Schwartz, PJ	1
Borggrefe, M; Lombardi, F; Lüderitz, B; Ruzyllo, W	1
Al-Khalidi, HR; Brum, JM; Dorian, P; Hohnloser, SH; Pratt, CM; Tatla, DS; Tchou, P	1
Guo, D; Kowey, PR; Liu, T; Wu, Y; Yan, GX; Zhao, X	1
Grant, AO; Tranquillo, J	1
Kaźmierczak, J; Peregud-Pogorzelska, M; Rzeuski, R	1
Connolly, S; Page, RL; Pritchett, EL; Wilkinson, WE	1
Nakaya, H; Nishida, A; Ogura, T; Reien, Y; Tamagawa, M; Uemura, H; Yabana, H	1
Bui-Xan, B; Chevalier, P; Dubieff, AD; Morel, E; Pineau, J; Piqueras, E; Rivard, L; Timour, Q	1
Sharma, S	1
Camm, J; Savelieva, I	1
Mitchell, LB	1
Conway, E; Kowey, PR; Musco, S	1
Al-Khalidi, HR; Brum, JM; Dorian, P; Dunnmon, PM; Hohnloser, SH; Holroyde, MJ; Kowey, P; Pratt, CM	1
Cannom, DS; Gidney, B	1
Kimura, J; Watanabe, Y	1
Ducroq, J; Legrand, JC; Puddu, PE; Rouet, R; Sallé, L	1
Tang, YQ; Wang, XJ; Yang, Q; You, QD	1
Furutani, K; Inanobe, A; Iwata, M; Kurachi, Y; Ohno, Y; Yamakawa, Y	1
Anderson, JL; Bunch, TJ	1
Bharucha, DB; Dorian, P; Kowey, PR; Mahaffey, KW; Robinson, VM	1

Reviews

24 review(s) available for hydantoins and azimilide

Article	Year
Azimilide dihydrochloride, a novel antiarrhythmic agent. The American journal of cardiology, 1998, Mar-19, Volume: 81, Issue:6A Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Humans; Hydantoins; Imidazoles; Imidazolidines; Piperazines; Potassium Channel Blockers	1998
New advances in class III antiarrhythmic drug therapy. Current opinion in cardiology, 1999, Volume: 14, Issue:1 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Denmark; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Postoperative Complications; Potassium Channel Blockers; Randomized Controlled Trials as Topic; Sulfonamides	1999
New advances in class III antiarrhythmic drug therapy. Current opinion in cardiology, 2000, Volume: 15, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides	2000
Azimilide dihydrochloride: a new class III anti-arrhythmic agent. Expert opinion on investigational drugs, 2000, Volume: 9, Issue:11 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Humans; Hydantoins; Imidazoles; Imidazolidines; Piperazines	2000
Clinical differences between the newer antiarrhythmic agents. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2000, Volume: 1 Suppl C Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dronedarone; Heart Conduction System; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sulfonamides	2000
New antiarrhythmic agents for atrial fibrillation. Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Humans; Hydantoins; Imidazoles; Imidazolidines; Lidocaine; Phenethylamines; Piperazines; Sulfonamides	2001
A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4 Topics: Analysis of Variance; Anti-Arrhythmia Agents; Bilirubin; Body Weight; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Ethnicity; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Middle Aged; Models, Statistical; Piperazines; Potassium; Reproducibility of Results; Sex Factors; Smoking; Tachycardia, Supraventricular	2001
New antiarrhythmic drugs for the treatment of atrial fibrillation. Pacing and clinical electrophysiology : PACE, 2002, Volume: 25, Issue:2 Topics: Aminobenzoates; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dronedarone; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides	2002
[Current strategies of pharmacological and non-pharmacological treatment in atrial fibrillation and atrial flutter]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:7 Topics: Atrial Fibrillation; Atrial Flutter; Body Surface Potential Mapping; Catheter Ablation; Clinical Trials as Topic; Electrophysiology; Humans; Hydantoins; Imidazoles; Imidazolidines; Pacemaker, Artificial; Piperazines; Sulfonamides	2002
[Drug therapy of ventricular arrhythmias - a contemporary perspective]. Deutsche medizinische Wochenschrift (1946), 2002, Oct-25, Volume: 127, Issue:43 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Death, Sudden, Cardiac; Defibrillators, Implantable; Double-Blind Method; Follow-Up Studies; Heart Failure; Heart Ventricles; Humans; Hydantoins; Imidazoles; Imidazolidines; Meta-Analysis as Topic; Piperazines; Placebos; Primary Prevention; Prospective Studies; Quality of Life; Randomized Controlled Trials as Topic; Risk Factors; Time Factors	2002
Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues. The American journal of cardiology, 2003, Mar-20, Volume: 91, Issue:6A Topics: Amiodarone; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart Conduction System; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Risk Assessment; Risk Factors; Sex Factors; Sotalol; Sulfonamides; Tachycardia; Torsades de Pointes	2003
Pure class III agents for prevention of sudden cardiac death. Journal of cardiovascular electrophysiology, 2003, Volume: 14, Issue:9 Suppl Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Comorbidity; Death, Sudden, Cardiac; Europe; Humans; Hydantoins; Imidazoles; Imidazolidines; Middle Aged; Myocardial Infarction; Phenethylamines; Piperazines; Randomized Controlled Trials as Topic; Sotalol; Sulfonamides; Survival Analysis; Treatment Outcome	2003
Oral class III antiarrhythmics: what is new? Current opinion in cardiology, 2004, Volume: 19, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Dronedarone; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides; Tachycardia, Supraventricular; Tachycardia, Ventricular; Treatment Outcome	2004
Azimilide for atrial fibrillation: clinical trial results and implications. Cardiac electrophysiology review, 2003, Volume: 7, Issue:3 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Electrocardiography; Humans; Hydantoins; Imidazoles; Imidazolidines; Myocardial Infarction; Piperazines; Randomized Controlled Trials as Topic; Treatment Outcome	2003
Trials of new antiarrhythmic drugs for maintenance of sinus rhythm in patients with atrial fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2004, Volume: 10 Suppl 1 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Cyclopropanes; Dronedarone; Humans; Hydantoins; Imidazoles; Imidazolidines; Indoles; Oxazines; Phenethylamines; Piperazines; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides	2004
Recent developments in cardiovascular drug therapy: treatment of atrial arrhythmias with new class III drugs and beyond. Current medicinal chemistry. Cardiovascular and hematological agents, 2004, Volume: 2, Issue:1 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Clinical Trials as Topic; Electric Countershock; Electrophysiology; Humans; Hydantoins; Imidazolidines; Pacemaker, Artificial; Phenethylamines; Piperazines; Sulfonamides	2004
A benefit-risk assessment of class III antiarrhythmic agents. Expert opinion on drug safety, 2004, Volume: 3, Issue:6 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Combined Modality Therapy; Defibrillators, Implantable; Dronedarone; Heart Conduction System; Humans; Hydantoins; Imidazolidines; Ion Transport; Life Tables; Membrane Potentials; Meta-Analysis as Topic; Phenethylamines; Piperazines; Risk Assessment; Sotalol; Sulfonamides; Survival Analysis; Torsades de Pointes; Treatment Outcome	2004
Adjunctive therapy for recurrent ventricular tachycardia in patients with implantable cardioverter defibrillators. Current cardiology reports, 2007, Volume: 9, Issue:5 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Combined Modality Therapy; Defibrillators, Implantable; Humans; Hydantoins; Imidazolidines; Piperazines; Secondary Prevention; Sotalol; Tachycardia, Ventricular; Treatment Outcome	2007
Antiarrhythmic drugs: present and future. The Journal of the Association of Physicians of India, 2007, Volume: 55 Suppl Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Design; Humans; Hydantoins; Imidazolidines; Ion Channels; Piperazines; Sotalol	2007
Update on atrial fibrillation: part II. Clinical cardiology, 2008, Volume: 31, Issue:3 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Humans; Hydantoins; Imidazolidines; Piperazines; Pulmonary Veins	2008
Role of drug therapy for sustained ventricular tachyarrhythmias. Cardiology clinics, 2008, Volume: 26, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Carbazoles; Carvedilol; Digoxin; Heart Conduction System; Humans; Hydantoins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazolidines; Piperazines; Propanolamines; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Sotalol; Tachycardia, Ventricular	2008
New horizons in antiarrhythmic therapy: will novel agents overcome current deficits? The American journal of cardiology, 2008, Sep-22, Volume: 102, Issue:6A Topics: Amiodarone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anisoles; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Cyclopropanes; Dronedarone; Humans; Hydantoins; Imidazolidines; Piperazines; Pyrrolidines	2008
[The research practice of anti-arrhythmic agents targeting on potassium ion channel]. Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:1 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dronedarone; Humans; Hydantoins; Imidazolidines; Molecular Structure; Piperazines; Potassium Channel Blockers; Potassium Channels	2011
Adjuvant antiarrhythmic therapy in patients with implantable cardioverter defibrillators. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2014, Volume: 14, Issue:2 Topics: Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Benzofurans; Defibrillators, Implantable; Humans; Hydantoins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazolidines; Mineralocorticoid Receptor Antagonists; Phenethylamines; Piperazines; Sotalol; Sulfonamides	2014

Trials

27 trial(s) available for hydantoins and azimilide

Article	Year
Effect of age and gender on azimilide pharmacokinetics after a single oral dose of azimilide dihydrochloride. Journal of clinical pharmacology, 1997, Volume: 37, Issue:10 Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Calcium Channel Blockers; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Middle Aged; Piperazines; Sex Factors	1997
The azimilide post-infarct survival evaluation (ALIVE) trial. The American journal of cardiology, 1998, Mar-19, Volume: 81, Issue:6A Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Middle Aged; Myocardial Infarction; Piperazines; Risk Factors; Stroke Volume; Survival Rate	1998
Azimilide pharmacokinetics and pharmacodynamics upon multiple oral dosing. Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Drug Administration Schedule; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Piperazines	1999
Pharmacokinetics and pharmacodynamics following intravenous doses of azimilide dihydrochloride. Journal of clinical pharmacology, 1999, Volume: 39, Issue:12 Topics: Adolescent; Adult; Calcium Channel Blockers; Demography; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Injections, Intravenous; Male; Piperazines	1999
Azimilide pharmacokinetics following intravenous and oral administration of a solution and capsule formulation. Journal of clinical pharmacology, 1999, Volume: 39, Issue:12 Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Humans; Hydantoins; Imidazoles; Imidazolidines; Injections, Intravenous; Male; Piperazines; Solutions	1999
Comparative oral bioavailability of azimilide dihydrochloride in the fed and fasted states. British journal of clinical pharmacology, 2000, Volume: 49, Issue:3 Topics: Administration, Oral; Adult; Biological Availability; Calcium Channel Blockers; Cross-Over Studies; Dietary Fats; Eating; Fasting; Food-Drug Interactions; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Piperazines	2000
Antiarrhythmic effects of azimilide in atrial fibrillation: efficacy and dose-response. Azimilide Supraventricular Arrhythmia Program 3 (SVA-3) Investigators. Journal of the American College of Cardiology, 2000, Volume: 36, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Middle Aged; Piperazines; Treatment Outcome	2000
Antiarrhythmic effects of azimilide in paroxysmal supraventricular tachycardia: efficacy and dose-response. American heart journal, 2002, Volume: 143, Issue:4 Topics: Adult; Aged; Anti-Arrhythmia Agents; Double-Blind Method; Electrocardiography; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Middle Aged; Patient Selection; Piperazines; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Telemetry; Torsades de Pointes	2002
Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillation. Journal of clinical pharmacology, 2002, Volume: 42, Issue:4 Topics: Analysis of Variance; Anti-Arrhythmia Agents; Arrhythmia, Sinus; Atrial Fibrillation; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Piperazines	2002
The effect of isoproterenol on the class III effect of azimilide in humans. Journal of cardiovascular pharmacology and therapeutics, 2002, Volume: 7, Issue:4 Topics: Action Potentials; Adrenergic beta-Agonists; Adult; Aged; Anti-Arrhythmia Agents; Drug Synergism; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Isoproterenol; Male; Middle Aged; Piperazines; Single-Blind Method; Ventricular Fibrillation; Ventricular Function, Right	2002
Asymptomatic or "silent" atrial fibrillation: frequency in untreated patients and patients receiving azimilide. Circulation, 2003, Mar-04, Volume: 107, Issue:8 Topics: Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Endpoint Determination; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Male; Middle Aged; Piperazines; Secondary Prevention	2003
Symptoms at the time of arrhythmia recurrence in patients receiving azimilide for control of atrial fibrillation or flutter: results from randomized trials. American heart journal, 2003, Volume: 146, Issue:3 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Chest Pain; Dizziness; Double-Blind Method; Dyspnea; Fatigue; Heart Rate; Humans; Hydantoins; Imidazoles; Imidazolidines; Piperazines; Recurrence	2003
Azimilide decreases recurrent ventricular tachyarrhythmias in patients with implantable cardioverter defibrillators. Journal of the American College of Cardiology, 2004, Jan-07, Volume: 43, Issue:1 Topics: Aged; Anti-Arrhythmia Agents; Defibrillators, Implantable; Double-Blind Method; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Pilot Projects; Piperazines; Recurrence; Tachycardia, Ventricular	2004
Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification. Circulation, 2004, Mar-02, Volume: 109, Issue:8 Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Double-Blind Method; Female; Heart Rate; Humans; Hydantoins; Imidazoles; Imidazolidines; Life Tables; Male; Middle Aged; Myocardial Infarction; Neutropenia; Piperazines; Potassium Channel Blockers; Risk Factors; Survival Analysis; Torsades de Pointes; Treatment Outcome; Ventricular Dysfunction, Left	2004
Influence of azimilide on CYP2C19-mediated metabolism. Journal of clinical pharmacology, 2004, Volume: 44, Issue:4 Topics: Adult; Anti-Arrhythmia Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CYP2C19; Double-Blind Method; Enzyme Inhibitors; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Piperazines	2004
The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial. Journal of the American College of Cardiology, 2004, Apr-07, Volume: 43, Issue:7 Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Double-Blind Method; Female; Follow-Up Studies; Heart Failure; Heart Rate; Humans; Hydantoins; Hypertension; Imidazoles; Imidazolidines; Male; Middle Aged; Neutropenia; Piperazines; Prevalence; Systole; Treatment Outcome; Ventricular Dysfunction, Left	2004
Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator. Circulation, 2004, Dec-14, Volume: 110, Issue:24 Topics: Anti-Arrhythmia Agents; Defibrillators, Implantable; Double-Blind Method; Electric Countershock; Endpoint Determination; Female; Humans; Hydantoins; Imidazolidines; Male; Middle Aged; Piperazines; Secondary Prevention; Tachycardia, Ventricular	2004
Influence of ketoconazole on azimilide pharmacokinetics in healthy subjects. British journal of clinical pharmacology, 2004, Volume: 58, Issue:6 Topics: Adult; Anti-Arrhythmia Agents; Antifungal Agents; Area Under Curve; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydantoins; Imidazolidines; Ketoconazole; Male; Middle Aged; Piperazines; Protein Binding	2004
Influence of coadministration on the pharmacokinetics of azimilide dihydrochloride and digoxin. Journal of clinical pharmacology, 2005, Volume: 45, Issue:7 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Cardiotonic Agents; Cross-Over Studies; Digoxin; Drug Combinations; Drug Interactions; Electrocardiography; Humans; Hydantoins; Imidazolidines; Male; Piperazines	2005
The metabolic profile of azimilide in man: in vivo and in vitro evaluations. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:9 Topics: Adult; Anti-Arrhythmia Agents; Area Under Curve; Carbon Radioisotopes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Feces; Humans; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Microsomes, Liver; Piperazines; Time Factors	2005
Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm. American heart journal, 2006, Volume: 151, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Female; Heart Rate; Humans; Hydantoins; Imidazolidines; Long QT Syndrome; Male; Middle Aged; Piperazines; Syncope; Torsades de Pointes; Treatment Outcome	2006
Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart disease. The American journal of cardiology, 2006, Jul-15, Volume: 98, Issue:2 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Confidence Intervals; Coronary Disease; Electrocardiography; Female; Heart Failure; Heart Rate; Humans; Hydantoins; Imidazolidines; Male; Middle Aged; Piperazines; Tachycardia, Paroxysmal; Treatment Outcome	2006
Azimilide vs. placebo and sotalol for persistent atrial fibrillation: the A-COMET-II (Azimilide-CardiOversion MaintEnance Trial-II) trial. European heart journal, 2006, Volume: 27, Issue:18 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Female; Humans; Hydantoins; Imidazolidines; Male; Middle Aged; Piperazines; Sotalol; Treatment Outcome	2006
Electrical storm in patients with an implantable defibrillator: incidence, features, and preventive therapy: insights from a randomized trial. European heart journal, 2006, Volume: 27, Issue:24 Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cohort Studies; Defibrillators, Implantable; Female; Humans; Hydantoins; Imidazolidines; Male; Middle Aged; Piperazines; Prospective Studies; Tachycardia, Ventricular; Treatment Outcome	2006
Azimilide for the treatment of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia: results of a randomized trial and insights on the concordance of symptoms and recurrent arrhythmias. Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:2 Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Endpoint Determination; Female; Humans; Hydantoins; Imidazolidines; Male; Piperazines; Secondary Prevention; Tachycardia, Supraventricular; Treatment Outcome	2008
Azimilide reduces emergency department visits and hospitalizations in patients with an implantable cardioverter-defibrillator in a placebo-controlled clinical trial. Journal of the American College of Cardiology, 2008, Sep-23, Volume: 52, Issue:13 Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Defibrillators, Implantable; Emergency Service, Hospital; Hospitalization; Humans; Hydantoins; Imidazolidines; Middle Aged; Piperazines	2008
Results of a curtailed randomized controlled trial, evaluating the efficacy and safety of azimilide in patients with implantable cardioverter-defibrillators: The SHIELD-2 trial. American heart journal, 2017, Volume: 185 Topics: Aged; Anti-Arrhythmia Agents; Cardiovascular Diseases; Death, Sudden, Cardiac; Defibrillators, Implantable; Double-Blind Method; Early Termination of Clinical Trials; Electric Countershock; Emergency Service, Hospital; Female; Heart Failure; Hospitalization; Humans; Hydantoins; Male; Middle Aged; Odds Ratio; Piperazines; Proportional Hazards Models; Stroke Volume; Tachycardia, Ventricular; Ventricular Fibrillation	2017

Other Studies

78 other study(ies) available for hydantoins and azimilide

Article	Year
Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Ferrets; Guinea Pigs; Heart; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Piperazines; Potassium Channel Blockers; Refractory Period, Electrophysiological	1995
Protection against programmed electrical stimulation-induced ventricular tachycardia and sudden cardiac death by NE-10064, a class III antiarrhythmic drug. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Heart Rate; Hydantoins; Imidazoles; Imidazolidines; Male; Myocardial Infarction; Piperazines; Piperidines; Tachycardia, Ventricular; Ventricular Fibrillation	1993
Comparison of the cardiac electrophysiologic effects of NE-10064 with sotalol and E-4031 and their modification by simulated ischaemia. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Myocardial Ischemia; Piperazines; Piperidines; Purkinje Fibers; Pyridines; Sheep; Sotalol	1994
Blockade of human IsK channels expressed in Xenopus oocytes by the novel class III antiarrhythmic NE-10064. European journal of pharmacology, 1994, Oct-13, Volume: 264, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Chloride Channels; Female; Gene Expression; Hydantoins; Imidazoles; Imidazolidines; Membrane Potentials; Microelectrodes; Oocytes; Piperazines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; RNA, Complementary; Xenopus laevis	1994
The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochemical and biophysical research communications, 1994, Jul-15, Volume: 202, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Cloning, Molecular; Dose-Response Relationship, Drug; Evoked Potentials; Female; Guinea Pigs; Heart; Hydantoins; Imidazoles; Imidazolidines; Membrane Potentials; Myocardium; Oocytes; Piperazines; Potassium Channel Blockers; Potassium Channels; Recombinant Proteins; Xenopus	1994
Effect of channel modulation and pH on IsK inhibition by the novel class III antiarrhythmic azimilide (NE-10064). European journal of pharmacology, 1995, Oct-15, Volume: 291, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Evoked Potentials; Humans; Hydantoins; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Isoproterenol; Oocytes; Piperazines; Potassium Channels; Xenopus	1995
Efficacy of the class III antiarrhythmic agent azimilide in rodent models of ventricular arrhythmia. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1996, Volume: 212, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chloroform; Constriction; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Hydantoins; Imidazoles; Imidazolidines; Male; Mice; Ouabain; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley	1996
Dual actions of the novel class III antiarrhythmic drug NE-10064 on delayed potassium channel currents in guinea pig ventricular and sinoatrial node cells. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Hydantoins; Imidazoles; Imidazolidines; Piperazines; Potassium Channels; Sinoatrial Node	1996
Effects of azimilide dihydrochloride on circus movement atrial flutter in the canine sterile pericarditis model. Journal of cardiovascular electrophysiology, 1996, Volume: 7, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Evoked Potentials; Hydantoins; Imidazoles; Imidazolidines; Male; Movement; Myocardium; Pericarditis; Piperazines; Refractory Period, Electrophysiological	1996
Specific blockade of slowly activating I(sK) channels by chromanols -- impact on the role of I(sK) channels in epithelia. FEBS letters, 1996, Nov-04, Volume: 396, Issue:2-3 Topics: Animals; Chlorides; Chromans; Colforsin; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epithelium; Female; Hydantoins; Imidazoles; Imidazolidines; Intestinal Mucosa; Male; Oocytes; Patch-Clamp Techniques; Piperazines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Stereoisomerism; Structure-Activity Relationship; Xenopus	1996
Suppression of inducible ventricular arrhythmias by intravenous azimilide in dogs with previous myocardial infarction. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:6 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Dogs; Electrocardiography; Heart; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Infusions, Intravenous; Male; Myocardial Infarction; Piperazines; Sotalol	1996
IK of rabbit ventricle is composed of two currents: evidence for IKs. The American journal of physiology, 1996, Volume: 271, Issue:6 Pt 2 Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Anti-Arrhythmia Agents; Electric Conductivity; Electrophysiology; Gene Expression; Guinea Pigs; Heart; Humans; Hydantoins; Imidazoles; Imidazolidines; Isoproterenol; Mice; Molecular Sequence Data; Mutation; Oocytes; Piperazines; Potassium Channels; Rabbits; Rats; Ventricular Function; Xenopus laevis	1996
Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: dependence on blockade of K, Ca, and Na channels. Journal of cardiovascular electrophysiology, 1997, Volume: 8, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Dogs; Electric Stimulation; Electrophysiology; Heart; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Myocardium; Patch-Clamp Techniques; Piperazines; Potassium Channels; Sodium Channels; Time Factors	1997
Comparison of the rate-dependent properties of the class III antiarrhythmic agents azimilide (NE-10064) and E-4031: considerations on the mechanism of reverse rate-dependent action potential prolongation. Journal of cardiovascular electrophysiology, 1997, Volume: 8, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Guinea Pigs; Heart; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Myocardium; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium Channels; Pyridines; Time Factors	1997
The role of the IsK protein in the specific pharmacological properties of the IKs channel complex. British journal of pharmacology, 1997, Volume: 122, Issue:2 Topics: Animals; Chromans; Estradiol; Humans; Hydantoins; Imidazoles; Imidazolidines; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Mefenamic Acid; Mice; Oocytes; Patch-Clamp Techniques; Piperazines; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Xenopus	1997
Effects of azimilide and d,l-sotalol on the heart rate and blood pressure response to isoproterenol in anesthetized rats. Cardiovascular drugs and therapy, 1997, Volume: 11, Issue:4 Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Electrocardiography; Heart Rate; Hydantoins; Imidazoles; Imidazolidines; Isoproterenol; Male; Piperazines; Rats; Rats, Sprague-Dawley; Sotalol	1997
Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action. British journal of pharmacology, 1998, Volume: 123, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Electric Stimulation; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Hydantoins; Imidazoles; Imidazolidines; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Piperazines; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; RNA, Messenger; Trans-Activators; Xenopus	1998
Differential atrial versus ventricular activities of class III potassium channel blockers. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Ferrets; Heart; Hydantoins; Imidazoles; Imidazolidines; Male; Papillary Muscles; Phenethylamines; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides; Temperature; Ventricular Function	1998
Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide. Cardiovascular research, 1998, Volume: 37, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Calcium Channel Blockers; Electric Stimulation; Guinea Pigs; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Membrane Potentials; Nitrendipine; Papillary Muscles; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Random Allocation; Ryanodine; Verapamil	1998
Inhibition of isoproterenol-induced tachycardia by azimilide in the isolated perfused guinea pig heart. Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Electrocardiography; Guinea Pigs; Heart; Heart Rate; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Isoproterenol; Male; Piperazines; Quaternary Ammonium Compounds; Receptors, Adrenergic, beta; Sotalol; Tachycardia	1998
Azimilide causes reverse rate-dependent block while reducing both components of delayed-rectifier current in canine ventricular myocytes. Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Delayed Rectifier Potassium Channels; Dogs; Dose-Response Relationship, Drug; Heart Ventricles; Hydantoins; Imidazoles; Imidazolidines; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Ventricular Function	1998
Effects of the novel antiarrhythmic agent azimilide on experimental atrial fibrillation and atrial electrophysiologic properties. Cardiovascular research, 1998, Volume: 37, Issue:3 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Chi-Square Distribution; Dogs; Drug Administration Schedule; Electrocardiography; Female; Heart Atria; Heart Rate; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Sulfonamides	1998
Separation and quantitation of azimilide and its putative metabolites by capillary electrophoresis. Journal of chromatography. B, Biomedical sciences and applications, 1998, Dec-11, Volume: 720, Issue:1-2 Topics: Anti-Arrhythmia Agents; Electrophoresis, Capillary; Hydantoins; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Piperazines; Reproducibility of Results; Spectrophotometry, Ultraviolet; Surface-Active Agents	1998
Azimilide decreases defibrillation voltage requirements and increases spatial organization during ventricular fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 1999, Volume: 3, Issue:1 Topics: Algorithms; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric Countershock; Electrodes, Implanted; Electrophysiology; Female; Heart Rate; Hydantoins; Imidazoles; Imidazolidines; Injections, Intravenous; Male; Piperazines; Treatment Outcome; Ventricular Fibrillation	1999
Effects of azimilide, a KV(r) and KV(s) blocker, on canine ventricular arrhythmia models. European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2 Topics: Anesthetics; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Epinephrine; Female; Halothane; Hydantoins; Imidazoles; Imidazolidines; Infusions, Intravenous; Injections, Intravenous; Male; Myocardial Reperfusion Injury; Pentobarbital; Piperazines; Potassium Channel Blockers; Ventricular Fibrillation	1999
Electrophysiology test may predict SCD (sudden cardiac death) risk: investigators induce VT in CAD patients. Patient-focused care and satisfaction, 1999, Volume: 7, Issue:8 Topics: Anti-Arrhythmia Agents; Coronary Disease; Death, Sudden, Cardiac; Electrophysiology; Humans; Hydantoins; Imidazoles; Imidazolidines; Piperazines; Risk Assessment; Tachycardia, Ventricular; United States	1999
Use-dependent 'agonist' effect of azimilide on the HERG channel. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: Animals; Cation Transport Proteins; Cell Membrane; DNA Mutational Analysis; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; GTP-Binding Proteins; Humans; Hydantoins; Imidazoles; Imidazolidines; Ion Channel Gating; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Conformation; Protein Kinases; Trans-Activators; Transcription, Genetic; Transcriptional Regulator ERG; Xenopus laevis	1999
Azimilide. NE 10064, Stedicor. Drugs in R&D, 1999, Volume: 1, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drugs, Investigational; Guinea Pigs; Humans; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Piperazines; Potassium Channel Blockers	1999
[Azimilide: Search for an effective and well-tolerated anti-arrhythmia agent]. Zeitschrift fur Kardiologie, 1999, Volume: 88, Issue:10 Suppl Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death; Death, Sudden; Humans; Hydantoins; Imidazoles; Imidazolidines; Piperazines	1999
The class III effect of azimilide is not associated with reverse use-dependence in open-chest dogs. Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiac Pacing, Artificial; Delayed Rectifier Potassium Channels; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hydantoins; Imidazoles; Imidazolidines; Male; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Refractory Period, Electrophysiological; Ventricular Fibrillation	1999
Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 223, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Female; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Male; Methoxamine; Phenethylamines; Piperazines; Procainamide; Quaternary Ammonium Compounds; Rabbits; Sotalol; Sulfonamides	2000
Azimilide. Drugs, 2000, Volume: 59, Issue:2 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Headache; Humans; Hydantoins; Imidazoles; Imidazolidines; Piperazines; Recurrence; Torsades de Pointes	2000
Effects of azimilide on cardiovascular tissues from normo- and hypertensive rats. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:2 Topics: Action Potentials; Animals; Blood Pressure; Cardiomegaly; Cardiotonic Agents; Cardiovascular System; Electric Stimulation; Heart Rate; Heart Ventricles; Hydantoins; Hypertension; Imidazoles; Imidazolidines; In Vitro Techniques; Mesenteric Arteries; Myocardial Contraction; Piperazines; Portal Vein; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Inbred WKY	2000
Effects of intravenous azimilide on cardiac performance, fibrillation threshold, and hemodynamics in anesthetized dogs. Arzneimittel-Forschung, 2000, Volume: 50, Issue:7 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Infusions, Intravenous; Injections, Intravenous; Male; Myocardial Contraction; Piperazines; Refractory Period, Electrophysiological; Sotalol; Vascular Resistance; Ventricular Fibrillation	2000
Effects of azimilide, acidemia, and the combination on defibrillation energy requirements. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Electrocardiography; Female; Hydantoins; Hydrochloric Acid; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Male; Piperazines	2000
Delayed rectifier K currents have reduced amplitudes and altered kinetics in myocytes from infarcted canine ventricle. Cardiovascular research, 2000, Volume: 48, Issue:1 Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Dogs; Electrophysiology; Hydantoins; Imidazoles; Imidazolidines; Myocardial Infarction; Myocardium; Nisoldipine; Patch-Clamp Techniques; Piperazines; Potassium Channels; RNA, Messenger; Sodium; Sodium-Potassium-Exchanging ATPase; Time Factors	2000
Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel. Cardiovascular research, 2000, Volume: 48, Issue:1 Topics: Aminobenzoates; Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds, Heterocyclic; Cation Transport Proteins; CHO Cells; Cricetinae; Depression, Chemical; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydantoins; Imidazoles; Imidazolidines; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Trans-Activators; Transcriptional Regulator ERG	2000
Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias. European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Heart Block; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sulfonamides; Torsades de Pointes; Ventricular Function	2001
Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall. Circulation, 2001, Jun-12, Volume: 103, Issue:23 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiologic Techniques, Cardiac; Heart Conduction System; Heart Ventricles; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Long QT Syndrome; Myocardial Contraction; Piperazines; Rabbits; Sotalol; Species Specificity; Systole; Tachycardia, Ventricular; Ventricular Dysfunction, Left	2001
Interaction of azimilide with neurohumoral and channel receptors. Biochemical pharmacology, 2001, Oct-01, Volume: 62, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Binding Sites; Brain; Cattle; Dogs; Guinea Pigs; Hydantoins; Imidazoles; Imidazolidines; Kidney; Mice; Muscarinic Agonists; Muscarinic Antagonists; Piperazines; Rabbits; Rats; Receptors, Adrenergic; Receptors, Muscarinic; Receptors, Neurotransmitter; Sodium-Potassium-Exchanging ATPase	2001
Efficacy of azimilide and dofetilide in the dog right atrial enlargement model of atrial flutter. Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Cardiomegaly; Dogs; Drug Evaluation, Preclinical; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Sulfonamides	2001
Effects of azimilide, a new class III antiarrhythmic drug, on reentrant circuits causing ventricular tachycardia and fibrillation in a canine model of myocardial infarction. Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Drug Evaluation, Preclinical; Electrocardiography; Hydantoins; Imidazoles; Imidazolidines; Male; Models, Animal; Myocardial Infarction; Piperazines; Tachycardia, Ventricular; Ventricular Fibrillation	2001
Dose-response relations of azimilide in the management of symptomatic, recurrent, atrial fibrillation. The American journal of cardiology, 2001, Nov-01, Volume: 88, Issue:9 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Dose-Response Relationship, Drug; Female; Heart Failure; Humans; Hydantoins; Imidazoles; Imidazolidines; Male; Middle Aged; Myocardial Ischemia; Piperazines; Randomized Controlled Trials as Topic; Recurrence	2001
Cardiovascular news. Circulation, 2001, Nov-27, Volume: 104, Issue:22 Topics: Acetanilides; Angina, Unstable; Anti-Arrhythmia Agents; Calcium Channel Blockers; Coronary Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Fondaparinux; Humans; Hydantoins; Imidazoles; Imidazolidines; Multicenter Studies as Topic; Myocardial Infarction; Nicorandil; Piperazines; Polysaccharides; Randomized Controlled Trials as Topic; Ranolazine; Treatment Outcome	2001
Is it rational, reasonable or excessive, and consistently applied? One view of the increasing FDA emphasis on safety first for the release and use of antiarrhythmic drugs for supraventricular arrhythmias. Journal of cardiovascular pharmacology and therapeutics, 2001, Volume: 6, Issue:4 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Approval; Drugs, Generic; Heart Ventricles; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sotalol; Sulfonamides; United States; United States Food and Drug Administration	2001
Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Biphenyl Compounds; Cation Transport Proteins; Electrophysiology; Ether-A-Go-Go Potassium Channels; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Kv1.5 Potassium Channel; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sotalol; Sulfonamides; Swine; Ventricular Function	2002
Effect of severe renal impairment on the pharmacokinetics of azimilide following single dose oral administration. British journal of clinical pharmacology, 2002, Volume: 54, Issue:5 Topics: Administration, Oral; Anti-Arrhythmia Agents; Area Under Curve; Chromatography, High Pressure Liquid; Female; Humans; Hydantoins; Imidazoles; Imidazolidines; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Piperazines; Regression Analysis	2002
Azimilide inhibits multiple cardiac potassium currents in human atrial myocytes. Journal of cardiovascular pharmacology and therapeutics, 2002, Volume: 7, Issue:4 Topics: Analysis of Variance; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Membrane Potentials; Myocytes, Cardiac; Piperazines; Potassium Channels	2002
Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2 Topics: 8,11,14-Eicosatrienoic Acid; alpha-Linolenic Acid; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Hydantoins; Imidazoles; Imidazolidines; Infant, Newborn; Linoleic Acids; Membrane Potentials; Neuroblastoma; Patch-Clamp Techniques; Piperazines; Piperidines; Pituitary Neoplasms; Polyunsaturated Alkamides; Potassium Channels; Pyridines; Tumor Cells, Cultured	2003
Preserved effects of potassium channel blockers in the pacing-induced remodeled canine atrium: a comparison between E4031 and azimilide. Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:5 Topics: Animals; Atrial Fibrillation; Atrial Function; Cardiac Pacing, Artificial; Dogs; Electric Stimulation; Electrocardiography; Electrodes, Implanted; Female; Hydantoins; Imidazoles; Imidazolidines; Male; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological	2003
Multiple cellular electrophysiological effects of azimilide in canine cardiac preparations. European journal of pharmacology, 2003, Jun-06, Volume: 470, Issue:3 Topics: Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Female; Heart Ventricles; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Papillary Muscles; Piperazines; Ventricular Function	2003
[Progress in the clinical use of anti-arrhythmic drugs (I)]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Child; Clinical Trials as Topic; Humans; Hydantoins; Imidazoles; Imidazolidines; Phenethylamines; Piperazines; Sulfonamides	2003
Effect of mild and moderate hepatic impairment on azimilide pharmacokinetics following single dose oral administration. Journal of pharmaceutical sciences, 2004, Volume: 93, Issue:5 Topics: Administration, Oral; Adult; Aged; Confidence Intervals; Female; Humans; Hydantoins; Imidazolidines; Liver Diseases; Male; Middle Aged; Piperazines	2004
Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels. Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Delayed Rectifier Potassium Channels; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Hydantoins; Hydrogen-Ion Concentration; Imidazoles; Imidazolidines; Myocardial Ischemia; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quinidine; Sulfonamides; Transfection; Xenopus	2004
State-dependent blocking actions of azimilide dihydrochlo-ride (NE-10064) on human cardiac Na(+) channels. Circulation journal : official journal of the Japanese Circulation Society, 2004, Volume: 68, Issue:7 Topics: Dose-Response Relationship, Drug; Electrophysiology; Heart; Humans; Hydantoins; Imidazolidines; Membrane Potentials; Models, Cardiovascular; Patch-Clamp Techniques; Piperazines; Sodium Channel Blockers; Sodium Channels	2004
Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs. Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:7 Topics: Adrenergic beta-Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Atropine; Biphenyl Compounds; Chromans; Flecainide; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Propafenone; Propanolamines; Sotalol; Sulfonamides; Swine; Ventricular Function	2004
The shocking story of azimilide. Circulation, 2004, Dec-14, Volume: 110, Issue:24 Topics: Anti-Arrhythmia Agents; Defibrillators, Implantable; Electric Countershock; Humans; Hydantoins; Imidazolidines; Piperazines; Randomized Controlled Trials as Topic; Tachycardia, Ventricular	2004
Advantages and pitfalls of combining device-based and pharmacologic therapies for the treatment of ventricular arrhythmias: observations from a tertiary referral center. Pacing and clinical electrophysiology : PACE, 2004, Volume: 27, Issue:12 Topics: Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Combined Modality Therapy; Defibrillators, Implantable; Drug Interactions; Humans; Hydantoins; Imidazolidines; Pacemaker, Artificial; Piperazines; Sotalol; Tachycardia, Ventricular; Treatment Outcome	2004
Design of the SHock Inhibition Evaluation with Azimilide (SHIELD) study: a novel method to assess antiarrhythmic drug effect in patients with an implantable cardioverter-defibrillator. The American journal of cardiology, 2005, Jan-15, Volume: 95, Issue:2 Topics: Anti-Arrhythmia Agents; Defibrillators, Implantable; Double-Blind Method; Drug Administration Schedule; Humans; Hydantoins; Imidazolidines; Piperazines; Randomized Controlled Trials as Topic; Research Design; Tachycardia, Ventricular; Treatment Outcome	2005
The influence of extracellular acidosis on the effect of IKr blockers. Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10, Issue:1 Topics: Acidosis; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Humans; Hydantoins; Imidazolidines; Myocardial Infarction; Oocytes; Phenethylamines; Piperazines; Potassium Channels; Potassium Channels, Voltage-Gated; Quinidine; Sulfonamides; Trans-Activators; Xenopus laevis	2005
Azimilide dihydrochloride. Expert review of cardiovascular therapy, 2005, Volume: 3, Issue:3 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Hydantoins; Imidazolidines; Piperazines	2005
Application of Raman spectroscopy for on-line monitoring of low dose blend uniformity. International journal of pharmaceutics, 2005, Jul-14, Volume: 298, Issue:1 Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Hydantoins; Imidazolidines; Piperazines; Spectrum Analysis, Raman; Technology, Pharmaceutical	2005
Electrophysiological effects of azimilide in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Ventricles; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenethylamines; Piperazines; Potassium Channel Blockers; Sulfonamides; Time Factors	2005
Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes. Journal of cardiovascular electrophysiology, 2005, Volume: 16, Issue:8 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Hydantoins; Imidazolidines; Male; Phenethylamines; Piperazines; Rabbits; Sulfonamides; Torsades de Pointes	2005
Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion. The Journal of general physiology, 2005, Volume: 126, Issue:4 Topics: Alkanes; Animals; Calcium; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Glucose; Humans; Hydantoins; Imidazolidines; Insulin; Insulin-Secreting Cells; KCNQ1 Potassium Channel; Membrane Potentials; Mice; Mice, Knockout; Piperazines; Potassium; Potassium Channels, Voltage-Gated; Quinolinium Compounds; Small-Conductance Calcium-Activated Potassium Channels; Time Factors; Transfection	2005
Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Female; Heart; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Piperazines; Refractory Period, Electrophysiological; Sodium Channels	2006
Electrophysiological and antiarrhythmic effects of the novel antiarrhythmic agent AZD7009: a comparison with azimilide and AVE0118 in the acutely dilated right atrium of the rabbit in vitro. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2006, Volume: 8, Issue:7 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biphenyl Compounds; Dilatation, Pathologic; Heart Atria; Hydantoins; Imidazolidines; In Vitro Techniques; Organic Chemicals; Piperazines; Rabbits	2006
Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database. Journal of the American College of Cardiology, 2006, Aug-01, Volume: 48, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Databases, Factual; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Hydantoins; Imidazolidines; Male; Middle Aged; Piperazines; Time Factors; Torsades de Pointes	2006
The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents. Cardiology, 2007, Volume: 108, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Disease Models, Animal; Electrophysiology; Extracellular Matrix; Female; Hydantoins; Hyperkalemia; Imidazolidines; Oocytes; Phenethylamines; Piperazines; Potassium Channels; Potassium Channels, Voltage-Gated; Probability; Sensitivity and Specificity; Sotalol; Sulfonamides; Xenopus laevis	2007
L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Guinea Pigs; Hydantoins; Imidazolidines; In Vitro Techniques; Myocytes, Cardiac; Nicardipine; Patch-Clamp Techniques; Phenethylamines; Piperazines; Rabbits; Sulfonamides	2007
Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation. Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Calcium Channels, L-Type; Guinea Pigs; Hydantoins; Imidazolidines; Myocytes, Cardiac; Nicardipine; Patch-Clamp Techniques; Phenethylamines; Piperazines; Rabbits; Sulfonamides; Torsades de Pointes	2007
QT Interval prolongation and torsades de pointes due to a coadministration of ciprofloxacin and azimilide in a patient with implantable cardioverter-defibrillator. Pacing and clinical electrophysiology : PACE, 2007, Volume: 30, Issue:8 Topics: Aged; Anti-Arrhythmia Agents; Anti-Infective Agents; Ciprofloxacin; Defibrillators, Implantable; Drug Interactions; Electrocardiography; Female; Humans; Hydantoins; Imidazolidines; Long QT Syndrome; Piperazines; Tachycardia, Ventricular; Torsades de Pointes	2007
Effects of azimilide on the muscarinic acetylcholine receptor-operated K+ current and experimental atrial fibrillation in guinea-pig hearts. Journal of pharmacological sciences, 2007, Volume: 105, Issue:3 Topics: Action Potentials; Animals; Atrial Fibrillation; Carbachol; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Heart Atria; Hydantoins; Imidazolidines; In Vitro Techniques; Muscarinic Antagonists; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Refractory Period, Electrophysiological	2007
The impact of acute myocardial ischemia on the ventricular defibrillation threshold during chronic oral azimilide therapy. Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:6 Topics: Acute Disease; Administration, Oral; Animals; Anti-Arrhythmia Agents; Defibrillators, Implantable; Electric Countershock; Electrocardiography; Female; Hydantoins; Imidazolidines; Long QT Syndrome; Male; Myocardial Ischemia; Piperazines; Swine; Ventricular Fibrillation	2007
Azimilide: another effort to prevent implantable cardioverter-defibrillator shocks and their sequelae why it is important and how it works. Journal of the American College of Cardiology, 2008, Sep-23, Volume: 52, Issue:13 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Defibrillators, Implantable; Humans; Hydantoins; Imidazolidines; Piperazines	2008
Inhibitory effect of azimilide on Na+/Ca2+ exchange current in guinea-pig cardiac myocytes. Journal of pharmacological sciences, 2010, Volume: 114, Issue:1 Topics: Animals; Guinea Pigs; Hydantoins; Imidazolidines; Myocytes, Cardiac; Ouabain; Piperazines; Sodium-Calcium Exchanger	2010
I(Kr) vs. I(Ks) blockade and arrhythmogenicity in normoxic rabbit Purkinje fibers: does it really make a difference? Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Delayed Rectifier Potassium Channels; Epinephrine; Hydantoins; Imidazolidines; In Vitro Techniques; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Purkinje Fibers; Rabbits; Sotalol; Sulfonamides	2011
A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents. Biochemical and biophysical research communications, 2011, Nov-11, Volume: 415, Issue:1 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydantoins; Imidazolidines; Membrane Potentials; Piperazines; Pyrimidinones; Xenopus laevis	2011