Page last updated: 2024-09-03

hwa 138 and pentoxifylline

hwa 138 has been researched along with pentoxifylline in 22 studies

Compound Research Comparison

Studies
(hwa 138)
Trials
(hwa 138)
Recent Studies (post-2010)
(hwa 138)
Studies
(pentoxifylline)
Trials
(pentoxifylline)
Recent Studies (post-2010) (pentoxifylline)
22004,437657943

Protein Interaction Comparison

ProteinTaxonomyhwa 138 (IC50)pentoxifylline (IC50)
AcetylcholinesteraseHomo sapiens (human)6.6

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.09)18.7374
1990's20 (90.91)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bahrami, S; Buurman, WA; Redl, H; Schlag, G1
Gunning, K; Masouyé, P; Morel, DR; Pittet, JF; Suter, PM1
Schmid-Schönbein, GW; Wong, PM1
Hawkins, EP; Kaplan, SL; Mason, EO; Rodriguez, AF1
Keyhani, A; Lopez-Berestein, G; Luke, DR; McQueen, TJ; Mehta, R; Vadiei, K; Wasan, KM; White, RA1
Berens, KL; Langston, JD; Luke, DR; Wasan, KM1
Berens, KL; Luke, DR; Verani, RR1
Lopez-Berestein, G; Luke, DR; McQueen, TJ; Wasan, KM1
Schade, UF1
Fujishima, S; Hatherill, JR; Hoffmann, H; Ishizaka, A; Raffin, TA; Yonemaru, M; Zheng, H1
Hand, DL; Hand, WL1
Duncker, HP; Koch, T; Möschet, B; Neuhof, H; Schönharting, M; Stein, A; van Ackern, K1
Bunk, A; Dapper, F; Hata, H; Hehrlein, FW; Neuhof, H1
Bahrami, S; Redl, H; Schlag, G; Yu, YH1
Lagarde, M; Meskini, N; Némoz, G; Okyayuz-Baklouti, I; Prigent, AF1
Alléra, A; Eisenhut, T; Endres, S; Gebert, U; Moeller, J; Schönharting, MM; Semmler, J1
Birg, A; Frank, G; Hoffmann, H; Jochum, M; Schönharting, MM; Weis, M1
Bauer, M; Herzog, C; Maier, M; Marzi, I1
Bahrami, S; Leichtfried, G; Redl, H; Schlag, G; Shiga, H; Yao, YM1
Bengtsson, A; Högåsen, K; Mollnes, TE; Redl, H; Schlag, G1
Bendtzen, K; Jakobsen, PH; Koch, C1
Kelleher, DK; Thews, O; Vaupel, P1

Other Studies

22 other study(ies) available for hwa 138 and pentoxifylline

ArticleYear
Influence of the xanthine derivate HWA 138 on endotoxin-related coagulation disturbances: effects in non-sensitized vs D-galactosamine sensitized rats.
    Thrombosis and haemostasis, 1992, Oct-05, Volume: 68, Issue:4

    Topics: Animals; Antithrombin III; Blood Coagulation Disorders; Blood Glucose; Fibrinogen; Galactosamine; Hematologic Tests; Immunization; In Vitro Techniques; Leukocyte Count; Lipopolysaccharides; Male; Partial Thromboplastin Time; Pentoxifylline; Platelet Count; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

1992
Xanthine derivative HWA 138 attenuates hemodynamic and oxygen uptake dysfunction secondary to severe endotoxin shock in sheep.
    Circulatory shock, 1992, Volume: 36, Issue:2

    Topics: Animals; Disease Models, Animal; Endotoxins; Escherichia coli; Female; Half-Life; Hemodynamics; Male; Oxygen Consumption; Pentoxifylline; Sheep; Shock, Septic

1992
Attenuation of spontaneous pseudopod formation in human neutrophils by pentoxifylline.
    Cell biophysics, 1991, Volume: 18, Issue:3

    Topics: Actins; Adult; Complement C5a; Cytoplasm; Dose-Response Relationship, Drug; Endotoxins; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentoxifylline; Pseudopodia; Receptors, Purinergic; Theophylline; Time Factors

1991
Effect of dexamethasone or HWA-138 in combination with antibiotics in experimental Haemophilus influenzae type b infection.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:10

    Topics: Ampicillin; Animals; Animals, Newborn; Anti-Bacterial Agents; Bronchodilator Agents; Cefotaxime; Cefuroxime; Child; Dexamethasone; Drug Therapy, Combination; Ear, Inner; Haemophilus Infections; Haemophilus influenzae; Humans; Pentoxifylline; Rats; Rats, Inbred Strains

1991
Antifungal activity of HWA-138 and amphotericin B in experimental systemic candidiasis.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:10

    Topics: Amphotericin B; Animals; Antifungal Agents; Candidiasis; Drug Synergism; Mice; Mice, Inbred ICR; Pentoxifylline

1991
Influence of pentoxifylline and related analogues in endotoxemic renal failure.
    Circulatory shock, 1991, Volume: 34, Issue:3

    Topics: Acute Kidney Injury; Animals; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Kidney; Male; Pentoxifylline; Rats; Rats, Inbred Strains

1991
Benefit of vascular decongestion in glycerol-induced acute renal failure.
    Renal failure, 1991, Volume: 13, Issue:2-3

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Blood Vessels; Dose-Response Relationship, Drug; Glycerol; Kidney; Kidney Tubular Necrosis, Acute; Male; Pentoxifylline; Random Allocation; Rats; Rats, Inbred Strains

1991
Enhancement of the treatment of experimental candidiasis with vascular decongestants.
    The Journal of infectious diseases, 1990, Volume: 162, Issue:1

    Topics: Amphotericin B; Animals; Candidiasis; Drug Therapy, Combination; Glomerular Filtration Rate; Kidney; Male; Pentoxifylline; Random Allocation; Rats; Rats, Inbred Strains; Renal Circulation; Theobromine; Vasoconstrictor Agents

1990
The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice.
    Eicosanoids, 1989, Volume: 2, Issue:3

    Topics: Animals; Endotoxins; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pentoxifylline; Theobromine; Tumor Necrosis Factor-alpha

1989
Attenuation of acute lung injury in septic guinea-pigs by a new xanthine derivative (HWA-138).
    Pharmatherapeutica, 1989, Volume: 5, Issue:6

    Topics: Acute Disease; Animals; Blood Pressure; Bronchodilator Agents; Erythrocytes; Escherichia coli Infections; Guinea Pigs; Injections, Intravenous; Iodine Radioisotopes; Leukocyte Count; Lung Diseases; Pentoxifylline; Respiratory Tract Infections; Theobromine

1989
Influence of pentoxifylline and its derivatives on antibiotic uptake and superoxide generation by human phagocytic cells.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:7

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Cells, Cultured; Clindamycin; Drug Interactions; Erythromycin; Humans; Macrolides; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentoxifylline; Phagocytosis; Respiratory Burst; Roxithromycin; Superoxides

1995
Influence of a pentoxifylline-analogue on the granulocyte-mediated pulmonary mediator release and vascular reaction.
    Circulatory shock, 1993, Volume: 40, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Female; Histamine Release; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentoxifylline; Pulmonary Artery; Rabbits; Tetradecanoylphorbol Acetate; Thromboxane B2; Vascular Resistance

1993
Experimental studies of the influence of priming solutions on the systemic activation of complement during cardiopulmonary bypass: comparison between the use of albumin, hydroxyethyl starch and HWA-138.
    The Journal of cardiovascular surgery, 1993, Volume: 34, Issue:2

    Topics: Albumins; Cardiopulmonary Bypass; Complement Activation; Complement C3a; Drug Evaluation, Preclinical; Female; Heart-Lung Machine; Humans; Hydroxyethyl Starch Derivatives; Intraoperative Period; Isotonic Solutions; Male; Multivariate Analysis; Pentoxifylline; Ringer's Solution; Time Factors

1993
Acute lung injury by endotoxin-induced mediators: prevention by HWA 138, a new xanthine derivative.
    The Journal of laboratory and clinical medicine, 1995, Volume: 125, Issue:4

    Topics: Animals; Cyclic AMP; Female; Humans; Lipopolysaccharides; Lung; Male; Neutrophils; Pentoxifylline; Rabbits; Sepsis

1995
Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation.
    Biochemical pharmacology, 1994, Mar-02, Volume: 47, Issue:5

    Topics: Animals; Heart Ventricles; Isoenzymes; Male; Microcirculation; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Xanthines

1994
Xanthine derivatives: comparison between suppression of tumour necrosis factor-alpha production and inhibition of cAMP phosphodiesterase activity.
    Immunology, 1993, Volume: 78, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Pentoxifylline; Theophylline; Tumor Necrosis Factor-alpha; Xanthines

1993
Amelioration of endotoxin-induced acute lung injury in pigs by HWA 138 and A 80 2715: new analogs of pentoxifylline.
    Shock (Augusta, Ga.), 1995, Volume: 4, Issue:3

    Topics: Animals; Bronchodilator Agents; Hemodynamics; Infusions, Intravenous; Leukocyte Count; Leukopenia; Lipopolysaccharides; Pentoxifylline; Pulmonary Circulation; Respiratory Distress Syndrome; Shock, Septic; Swine; Swine, Miniature; Xanthines

1995
Influence of pentoxifylline and albifylline on liver microcirculation and leukocyte adhesion after hemorrhagic shock in the rat.
    The Journal of trauma, 1996, Volume: 40, Issue:1

    Topics: Animals; Cell Adhesion Molecules; Disease Models, Animal; Female; Liver Circulation; Pentoxifylline; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Single-Blind Method; Vasodilator Agents

1996
Comparison of the efficacy of pentoxifylline and albifyllin (HWA 138) on endotoxin-induced cytokine production, coagulation disturbances, and mortality.
    Shock (Augusta, Ga.), 1996, Volume: 5, Issue:6

    Topics: Animals; Antithrombin III; Blood Coagulation Disorders; Bronchodilator Agents; Cytokines; Dose-Response Relationship, Drug; Endotoxins; Leukocytes; Male; Pentoxifylline; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

1996
Effects on complement activation and cytokine (TNF-alpha and IL-8) release of infusion of anti-TNF-antibodies or a xanthine derivative (HWA 138) in septic baboons.
    Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:2

    Topics: Animals; Antibodies; Complement Activation; Complement Membrane Attack Complex; Escherichia coli Infections; Hemodynamics; Interleukin-8; Male; Papio; Pentoxifylline; Sepsis; Tumor Necrosis Factor-alpha; Xanthines

1996
Inhibition of LPS and Plasmodium falciparum induced cytokine secretion by pentoxifylline and two analogues.
    Scandinavian journal of immunology, 1997, Volume: 45, Issue:5

    Topics: Adult; Animals; Cytokines; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Pentoxifylline; Phosphodiesterase Inhibitors; Plasmodium falciparum; Tumor Necrosis Factor-alpha

1997
Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration.
    International journal of radiation oncology, biology, physics, 1998, Nov-01, Volume: 42, Issue:4

    Topics: Animals; Male; Neoplasms, Experimental; Oxygen Consumption; Pentoxifylline; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sarcoma, Experimental; Vasodilator Agents

1998