huprine x has been researched along with tacrine in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gago, F; Luque, FJ; Martín-Santamaría, S; Muñoz-Muriedas, J | 1 |
| Belinskaya, T; Borriello, M; Butini, S; Campiani, G; Catalanotti, B; De Angelis, M; Fattorusso, C; Gabellieri, E; Gemma, S; Huleatt, P; Nacci, V; Novellino, E; Saxena, A | 1 |
| Badia, A; Camps, P; Clos, MV; Curutchet, C; Gómez, E; Luque, FJ; Muñoz-Muriedas, J; Muñoz-Torrero, D | 1 |
| Al-Rashid, ZF; Beri, V; Cheung, J; Rosenberry, TL; Shiomi, K; Wildman, SA | 1 |
| Barril, X; Camps, P; Dvir, H; Harel, M; Luque, FJ; Muñoz-Torrero, D; Orozco, M; Rosenberry, TL; Silman, I; Sussman, JL; Wong, DM | 1 |
| Badia, A; Camps, P; Clos, MV; Formosa, X; Muñoz-Torrero, D; Petrignet, J | 1 |
| Camps, P; Muñoz-Torrero, D | 1 |
1 review(s) available for huprine x and tacrine
| Article | Year |
|---|---|
Dimeric and hybrid anti-Alzheimer drug candidates.
Topics: Alzheimer Disease; Aminoquinolines; Animals; Binding Sites; Cholinesterase Inhibitors; Cognition Disorders; Heterocyclic Compounds, 4 or More Rings; Humans; Monoamine Oxidase Inhibitors; Piperidines; Structure-Activity Relationship; Tacrine | 2006 |
6 other study(ies) available for huprine x and tacrine
| Article | Year |
|---|---|
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Inhibitory Concentration 50; Protein Binding; Quantitative Structure-Activity Relationship; Structure-Activity Relationship | 2004 |
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Models, Molecular; Protein Binding; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine | 2006 |
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Anions; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Erythrocytes; Formamides; Glycine; Heterocyclic Compounds, 4 or More Rings; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tacrine | 2006 |
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.
Topics: Acetylcholine; Acetylcholinesterase; Aflatoxin B1; Binding Sites; Binding, Competitive; Catalysis; Catalytic Domain; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Humans; Hydrolysis; Kinetics; Models, Chemical; Phenanthrenes; Pyrans; Quinones; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity | 2013 |
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Binding Sites; Chlorine; Cholinesterase Inhibitors; Computer Simulation; Crystallization; Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Kinetics; Ligands; Models, Molecular; Protein Conformation; Sesquiterpenes; Species Specificity; Tacrine; Torpedo | 2002 |
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Aminoquinolines; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Structure-Activity Relationship; Tacrine | 2005 |