huprine x and tacrine

huprine x has been researched along with tacrine in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (85.71)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gago, F; Luque, FJ; Martín-Santamaría, S; Muñoz-Muriedas, J1
Belinskaya, T; Borriello, M; Butini, S; Campiani, G; Catalanotti, B; De Angelis, M; Fattorusso, C; Gabellieri, E; Gemma, S; Huleatt, P; Nacci, V; Novellino, E; Saxena, A1
Badia, A; Camps, P; Clos, MV; Curutchet, C; Gómez, E; Luque, FJ; Muñoz-Muriedas, J; Muñoz-Torrero, D1
Al-Rashid, ZF; Beri, V; Cheung, J; Rosenberry, TL; Shiomi, K; Wildman, SA1
Barril, X; Camps, P; Dvir, H; Harel, M; Luque, FJ; Muñoz-Torrero, D; Orozco, M; Rosenberry, TL; Silman, I; Sussman, JL; Wong, DM1
Badia, A; Camps, P; Clos, MV; Formosa, X; Muñoz-Torrero, D; Petrignet, J1
Camps, P; Muñoz-Torrero, D1

Reviews

1 review(s) available for huprine x and tacrine

ArticleYear
Dimeric and hybrid anti-Alzheimer drug candidates.
    Current medicinal chemistry, 2006, Volume: 13, Issue:4

    Topics: Alzheimer Disease; Aminoquinolines; Animals; Binding Sites; Cholinesterase Inhibitors; Cognition Disorders; Heterocyclic Compounds, 4 or More Rings; Humans; Monoamine Oxidase Inhibitors; Piperidines; Structure-Activity Relationship; Tacrine

2006

Other Studies

6 other study(ies) available for huprine x and tacrine

ArticleYear
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
    Journal of medicinal chemistry, 2004, Aug-26, Volume: 47, Issue:18

    Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Inhibitory Concentration 50; Protein Binding; Quantitative Structure-Activity Relationship; Structure-Activity Relationship

2004
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
    Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11

    Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Models, Molecular; Protein Binding; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine

2006
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
    Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23

    Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Anions; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Erythrocytes; Formamides; Glycine; Heterocyclic Compounds, 4 or More Rings; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tacrine

2006
The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.
    Biochemistry, 2013, Oct-22, Volume: 52, Issue:42

    Topics: Acetylcholine; Acetylcholinesterase; Aflatoxin B1; Binding Sites; Binding, Competitive; Catalysis; Catalytic Domain; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Humans; Hydrolysis; Kinetics; Models, Chemical; Phenanthrenes; Pyrans; Quinones; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity

2013
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
    Biochemistry, 2002, Mar-05, Volume: 41, Issue:9

    Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Binding Sites; Chlorine; Cholinesterase Inhibitors; Computer Simulation; Crystallization; Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Kinetics; Ligands; Models, Molecular; Protein Conformation; Sesquiterpenes; Species Specificity; Tacrine; Torpedo

2002
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
    Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6

    Topics: Acetylcholinesterase; Aminoquinolines; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Structure-Activity Relationship; Tacrine

2005