huprine x has been researched along with huprine y in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gago, F; Luque, FJ; Martín-Santamaría, S; Muñoz-Muriedas, J | 1 |
| Badia, A; Camps, P; Clos, MV; Curutchet, C; Gómez, E; Luque, FJ; Muñoz-Muriedas, J; Muñoz-Torrero, D | 1 |
| Camps, P; Cusack, B; El Achab, RE; Mallender, WD; Morral, J; Muñoz-Torrero, D; Rosenberry, TL | 1 |
| Aleu, J; Badia, A; Camps, P; Gómez de Aranda, I; Marsal, J; Muñoz-Torrero, D; Ros, E; Solsona, C | 1 |
| Badia, A; Camps, P; Clos, MV; Formosa, X; Muñoz-Torrero, D; Petrignet, J | 1 |
| Badia, A; Camps, P; Clos, MV; Colombo, L; Manzoni, C; Muñoz-Torrero, D; Pera, M; Ratia, M; Román, S; Salmona, M | 1 |
| Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Bidon-Chanal, A; Camins, A; Camps, P; Clos, MV; Galdeano, C; Gómez, T; Junyent, F; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Pallàs, M; Ramírez, L; Ratia, M; Rodríguez-Franco, MI; Verdaguer, E; Viayna, E | 1 |
| Carletti, E; Colletier, JP; Jean, L; Nachon, F; Renard, PY; Ronco, C; Weik, M | 1 |
8 other study(ies) available for huprine x and huprine y
| Article | Year |
|---|---|
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Topics: Algorithms; Artificial Intelligence; Cholinesterase Inhibitors; Inhibitory Concentration 50; Protein Binding; Quantitative Structure-Activity Relationship; Structure-Activity Relationship | 2004 |
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Anions; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Erythrocytes; Formamides; Glycine; Heterocyclic Compounds, 4 or More Rings; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tacrine | 2006 |
Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Acylation; Alzheimer Disease; Aminoquinolines; Binding, Competitive; Cholinesterase Inhibitors; Erythrocytes; Heterocyclic Compounds, 4 or More Rings; Humans; Intercalating Agents; Kinetics; Propidium | 2000 |
The pharmacology of novel acetylcholinesterase inhibitors, (+/-)-huprines Y and X, on the Torpedo electric organ.
Topics: Acetylcholine; Aminoquinolines; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electric Organ; Female; Heterocyclic Compounds, 4 or More Rings; Membrane Potentials; Oocytes; Stereoisomerism; Synapses; Torpedo; Xenopus | 2001 |
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Aminoquinolines; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Structure-Activity Relationship; Tacrine | 2005 |
Acetylcholinesterase triggers the aggregation of PrP 106-126.
Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Cattle; Cholinesterase Inhibitors; Coumarins; Heterocyclic Compounds, 4 or More Rings; Humans; Microscopy, Fluorescence; Peptide Fragments; Prions; Propidium; Protein Structure, Secondary; Sesquiterpenes | 2006 |
Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates.
Topics: Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Indans; Kinetics; Molecular Dynamics Simulation; Structure-Activity Relationship | 2010 |
Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Animals; Brain; Cholinesterase Inhibitors; Crystallography, X-Ray; Dogs; Heterocyclic Compounds, 4 or More Rings; Humans; Models, Molecular; Solutions; Stereoisomerism; Thermodynamics | 2012 |