huperzine a has been researched along with sesquiterpenes in 427 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (2.58) | 18.7374 |
| 1990's | 56 (13.11) | 18.2507 |
| 2000's | 177 (41.45) | 29.6817 |
| 2010's | 146 (34.19) | 24.3611 |
| 2020's | 37 (8.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ashani, Y; Doctor, BP; Peggins, JO | 1 |
| Ball, RG; Kozikowski, AP; McKinney, M; Miller, CP; Miller, JH; Pang, YP; Yamada, F | 1 |
| Han, YY; Ma, YX; Sang, GW; Tang, XC; Yang, RM; Zhang, CL; Zhang, RW; Zhang, YD | 1 |
| Kozikowski, AP; McKinney, M; Miller, JH; Tuckmantel, W; Yamada, F | 1 |
| Geib, SJ; Kozikowski, AP; Tückmantel, W | 1 |
| Corey, J; Hanin, I; Laganière, S; Tang, XC; Wülfert, E | 1 |
| De Sarno, P; Giacobini, E; Sugaya, K; Tang, XC | 1 |
| Chen, SS; Guan, LC; Lu, WH; Tang, XC | 1 |
| Tang, XC; Wang, YE; Yue, DX | 1 |
| Chen, XP; Han, YF; Tang, XC; Zhu, XD | 1 |
| Lou, WJ; Lu, WH; Tang, XC; Yan, XF | 1 |
| Lu, WH; Shou, J; Tang, XC | 1 |
| Gong, ZH; Hao, XY; Qin, BY | 1 |
| Feng, J; Lu, WH; Tang, XC; Wang, YE | 1 |
| Tang, XC; Zhu, XD | 2 |
| Giacobini, E; Zhu, XD | 1 |
| Bores, GM; Effland, RC; Fink, DM; Huger, FP; Kurys, BE; Rush, DK; Selk, DE | 1 |
| Kozikowski, AP; Pang, YP | 1 |
| Liu, HC; Liu, MY | 1 |
| Doctor, BP; Kovach, IM; Kozikowski, AP; Pang, YP; Qian, N; Quinn, D; Radić, Z; Saxena, A; Taylor, P; Vellom, DC | 1 |
| Hanin, I; Kindel, GH; Kozikowski, AP; Tang, XC | 1 |
| Feng, J; Liu, JS; Tang, XC; Xu, H; Zhou, TX | 1 |
| Tang, XC; Wang, MY; Zhang, GB; Zheng, JQ | 1 |
| Ashani, Y; Doctor, BP; Grunwald, J; Raveh, L | 1 |
| Ashani, Y; Grunwald, J; Kronman, C; Shafferman, A; Velan, B | 1 |
| Hanin, I; Kindel, GL; Kozikowski, AP; Tang, XC | 1 |
| XI, CT; Yi, FH; Zhi, QX | 1 |
| Chai, XS; Du, ZM; Fang, YS; Gao, ZX; Tong, ZH; Weng, Z; Xu, SS; Xu, WA; Yang, JS; Zhang, ML | 1 |
| Chen, GS; Chen, K; Qian, BC; Wang, M; Zhou, RR; Zhou, ZF | 1 |
| Harel, M; Kozikowski, AP; Pang, YP; Raves, ML; Silman, I; Sussman, JL | 1 |
| Cheng, DH; Ren, H; Tang, XC | 1 |
| Skolnick, AA | 1 |
| Dave, JR; Doctor, BP; Koenig, ML; Ved, HS | 1 |
| Aubriot, S; Baubichon, D; Burckhart, MF; Lallement, G; Masqueliez, C; Veyret, J | 1 |
| Mallender, WD; Rosenberry, TL; Szegletes, T | 1 |
| Badia, A; Baños, JE; Camps, P; Contreras, J; Görbig, DM; Muñoz-Torrero, D; Simón, M; Vivas, NM | 1 |
| Cheng, DH; Tang, XC | 1 |
| Tang, XC; Wang, T | 1 |
| Ariel, N; Barak, D; Bino, T; Ordentlich, A; Shafferman, A; Velan, B | 1 |
| Armour, JA; Darvesh, S; Hopkins, DA; Losier, AM; MacDonald, SE; Martin, E | 1 |
| Hu, GY; Lin, JH; Tang, XC | 2 |
| Tang, XC | 1 |
| Chen, KX; Ji, RY; Jiang, H; Liu, DX; Wang, QM | 1 |
| Campiani, G; Doctor, BP; Kozikowski, AP; Ming, L; Nacci, V; Saxena, A; Wang, S | 1 |
| Cai, JX; Tang, XC; Wang, LM; Ye, JW | 1 |
| Patocka, J | 1 |
| Albuquerque, EX; Aracava, Y; Chebabo, SR; Rocha, ES; Santos, MD | 1 |
| McCammon, JA; Straatsma, TP; Tara, S | 1 |
| Cheng, DH; Tang, XC; Xiong, ZQ | 1 |
| Tang, XC; Wang, H | 1 |
| Bai, DL; He, XC; Liu, J; Tang, XC; Wang, B; Zhang, HY | 1 |
| Helms, V; McCammon, JA; Straatsma, TP; Tara, S | 1 |
| Hu, GY; Wang, XD; Yang, HH; Zhang, JM | 1 |
| Badia, A; Barril, X; Camps, P; El Achab, R; Eladi Baños, J; Görbig, DM; Luque, FJ; Morral, J; Muñoz-Torrero, D; Orozco, M; Vivas, NM | 1 |
| Carlier, PR; Du, DM; Han, Y; Liu, J; Pang, YP | 1 |
| Masson, P; Pilotaz, F | 1 |
| Tang, XC; Xiao, XQ; Yang, JW | 1 |
| Qiao, JT; Ye, L | 1 |
| Barril, X; Luque, FJ; Orozco, M | 1 |
| Chen, K; Ji, R; Jiang, H; Zeng, F; Zhai, Y; Zhang, H | 1 |
| Kaur, J; Zhang, MQ | 1 |
| Bai, DL; He, XC; Tang, XC | 1 |
| Koellner, G; Kryger, G; Millard, CB; Silman, I; Steiner, T; Sussman, JL | 1 |
| Lallement, G | 1 |
| Cao, WQ; Guo, HM; Pan, JL; Sun, QQ; Xu, SS | 1 |
| Cai, YL; Cai, ZY; Cheng, RY; Feng, B; Li, JX; Qu, ZW; Su, XQ; Wang, GQ; Xu, SS; Xu, WA; Yang, RM; Zhong, XS | 1 |
| Mazurek, AA | 1 |
| Pepping, J | 1 |
| Han, YF; Tang, XC; Wang, R; Xiao, XQ | 1 |
| Han, YF; Tang, XC; Wang, LM | 1 |
| Tang, XC; Wang, R; Xiao, XQ | 2 |
| Zhou, GC; Zhu, DY | 1 |
| Chiu, HF; Zhang, M | 1 |
| Doctor, BP; Kozikowski, AP; Prakash, KR; Rajendran, V; Saxena, A; Ved, HS | 1 |
| Bai, DL; Chen, XQ; Hu, GY; Jin, GY; Yang, HH; Zhang, YH | 1 |
| Badia, A; Baños, JE; Barril, X; Camps, P; Luque, FJ; Morral, J; Muñoz-Torrero, D; Orozco, M; Vivas, NM | 1 |
| Eyer, P; Felgenhauer, N; Worek, F; Zilker, T | 1 |
| Qi, JS; Qiao, JT; Ye, L | 1 |
| Shang, YZ; Tang, XC; Ye, JW | 1 |
| Shang, YZ; Tang, XC; Wang, ZM; Ye, JW | 1 |
| Li, XY; Zhao, HW | 2 |
| Lallement, G; Masqueliez, C; Monmaur, P; Testylier, G; Tonduli, LS | 1 |
| Aubriot, S; Baubichon, D; Carpentier, P; Dorandeu, F; Foquin, A; Lallement, G | 1 |
| Baubichon, D; Carpentier, P; Dorandeu, F; Foquin, A; Lallement, G | 1 |
| Fu, Y; Tang, XC; Zhou, J | 2 |
| Tang, XC; Wang, R; Zhang, HY | 1 |
| Hu, GY; Zhang, JM | 1 |
| Gao, Y; Guan, LC; Kuang, PZ; Tang, XC | 1 |
| Tang, XC; Zhang, HY; Zhou, J | 1 |
| Tang, XC; Xiao, XQ; Zhang, HY | 1 |
| Cai, JX; Ou, LY; Tang, XC | 1 |
| Bai, DL; He, XC; Liang, YQ; Tang, XC; Zhang, HY | 1 |
| Ainge, GD; Gerard, PJ; Lorimer, SD; Ruf, LD | 1 |
| Chen, XQ; Hu, GY; Wang, Y; Yang, HH; Zhang, YH; Zhao, XY | 1 |
| Filliat, P; Foquin, A; Lallement, G | 1 |
| Barril, X; Camps, P; Dvir, H; Harel, M; Luque, FJ; Muñoz-Torrero, D; Orozco, M; Rosenberry, TL; Silman, I; Sussman, JL; Wong, DM | 1 |
| Dave, JR; Doctor, BP; Gordon, RK; Nigam, SV; Ved, HS; Weitz, JA | 1 |
| Hu, GY; Li, Y | 2 |
| Buckwalter, KC | 1 |
| Baille, V; Baubichon, D; Carpentier, P; Collombet, JM; Dorandeu, F; Filliat, P; Foquin, A; Four, E; Lallement, G; Masqueliez, C; Testylier, G; Tonduli, L | 1 |
| Baubichon, D; Clarençon, D; Demoncheaux, JP; Dorandeu, F; Foquin, A; Galonnier, M; Lallement, G | 1 |
| Chen, Q; Shan, G; Shu, L; Wang, J; Wang, X; Zhang, Z | 1 |
| Bai, DL; Chetrit, M; Dvir, H; Harel, M; He, XC; Jiang, HL; Jin, GY; Silman, I; Sussman, JL; Tang, XC; Wong, DM; Yu, GL | 1 |
| Tang, XC; Zhou, J | 1 |
| Shao, XM; Tang, XC; Wang, LS; Zhou, J | 2 |
| Camps, P; Muñoz-Torrero, D | 1 |
| Tang, XC; Zhao, Q | 1 |
| Carlier, PR; Dvir, H; Greenblatt, HM; Han, YF; Pang, YP; Silman, I; Sussman, JL; Wong, DM | 1 |
| Houghton, PJ; Howes, MJ; Perry, NS | 1 |
| Bai, DL; Jin, GY; Xia, Y | 1 |
| Ma, X; Tu, Z; Wang, H; Xin, J; Zhang, T | 1 |
| Ma, XC; Tu, ZH; Wang, HX; Xin, J; Zhang, T | 2 |
| Tang, XC; Zhang, HY | 2 |
| Alcalá, Mdel M; Badia, A; Camps, P; Hospital, S; Muñoz-Torrero, D; Vivas, NM | 1 |
| Darvesh, S; Martin, E; Walsh, R | 1 |
| Fugal, KB; Kou, XL; McLaughlin, JL; Yang, QP | 1 |
| Buerki, RA; Patil, KD; Patil, PN | 1 |
| Zangara, A | 1 |
| Brimijoin, S; Tang, XC; Zhang, HY | 1 |
| Bai, DL; He, XC; Yu, GL | 1 |
| Bentley, JM; Foricher, Y; Kelly, SA; Mann, J | 1 |
| Bai, D; Jiang, H; Luo, X | 1 |
| Bai, D; He, X; Jiang, H; Jin, G; Luo, X; Zhang, H | 1 |
| JASINSKA, MC | 1 |
| Jiang, S; Li, Q; Li, Y; Song, G; Sun, M; Zhu, D | 1 |
| Du, F; Li, C; Xu, F; Xu, X; Yu, C; Zheng, J; Zhu, D | 1 |
| Chu, D; Fawcett, JP; Gu, J; Liu, W; Wang, Y; Wu, Y | 1 |
| Tang, XC; Yan, H; Zhang, HY | 3 |
| Liang, YQ; Tang, XC | 2 |
| Jaroszewski, JW; Larsen, J; Larsen, LA; Olafsdottir, ES; Staerk, D; Witt, M | 1 |
| Li, XY; Liu, J; Zhu, XZ | 1 |
| Gang, DR; Ma, X | 2 |
| Ding, J; Fan, Y; Geng, M; Hu, J; Li, J; Wang, J; Xin, X; Yang, Z | 1 |
| Camins, A; Camps, P; Canudas, AM; Jiménez, A; Jordá, EG; Muñoz-Torrero, D; Pallàs, M; Rimbau, V; Verdaguer, E | 1 |
| Chen, G; Ye, J; Zeng, S; Zhang, W | 1 |
| Gang, DR; Ma, X; Tan, C; Zhu, D | 2 |
| André, C; Darrouzain, F; Guillaume, YC; Ismaili, L; Matoga, M | 1 |
| Tang, LL; Tang, XC; Wang, R | 2 |
| Dong So, D; Han, Y; Law, SL; Xu, Z; Xue, H; Zheng, H | 1 |
| Liu, L; Sun, JX | 1 |
| Tang, XC; Wang, R | 1 |
| Fu, X; Gao, Y; Ping, Q | 2 |
| Elosta, S; Hameda, AB; Havel, J | 1 |
| Chu, DF; Li, YX; Liu, K; Liu, WH; Song, JL | 1 |
| Fu, XD; Gao, YL; Ping, QN; Ren, T | 1 |
| Chen, K; Jiang, H; Luo, X; Shen, J; Silman, I; Sussman, JL; Xu, Y | 1 |
| Badia, A; Camps, P; Clos, MV; Muñoz-Torrero, D; Roman, S | 1 |
| Aisen, PS; Doctor, BP; Feaster, SR; Garcia, GE; Gordon, RK; Haigh, JR; Lenz, DE; Riel, MA | 1 |
| Copeland, CM; Crittenden, EL; Durdan, SF; García, DM; Neece, JD; Phatarpekar, PV | 1 |
| Liu, C; Lu, R; Wei, G; Xiao, S | 1 |
| Gu, Y; Wu, Q | 1 |
| Bi, JX; Li, XN; Ma, GH; Ma, RY; Su, ZG; Sun, HH; Zhang, GF | 1 |
| Tang, XC; Wang, R; Yan, H | 1 |
| Chen, D; Ding, P; Gao, P; Wei, J; Xu, H; Yuan, Z | 1 |
| Bannwarth, B; Dallet, P; Darrouzain, F; Dubost, JP; Guillaume, YC; Ismaili, L; Matoga, M; Pehourcq, F | 1 |
| Gao, X; Tang, XC | 1 |
| Hu, X; Jin, R; Pan, J | 1 |
| Tang, LL; Tang, XC; Wang, YJ; Wang, ZF; Yan, H | 1 |
| Belinskaya, T; Borriello, M; Butini, S; Campiani, G; Catalanotti, B; De Angelis, M; Fattorusso, C; Gabellieri, E; Gemma, S; Huleatt, P; Nacci, V; Novellino, E; Saxena, A | 1 |
| Badia, A; Camps, P; Clos, MV; Colombo, L; Manzoni, C; Muñoz-Torrero, D; Pera, M; Ratia, M; Román, S; Salmona, M | 1 |
| Chu, D; Gu, J; Li, P; Li, Y; Liu, K; Liu, W | 1 |
| Eckert, S; Eyer, P; Mückter, H; Worek, F | 1 |
| Beck, C; Blank, K; Colenda, CC; Doraiswamy, MP; Kalunian, DA; Lyketsos, CG; Yaffe, K | 1 |
| Liu, L; Sun, JX; Wang, J; Xie, GY | 1 |
| Jiang, L; Lee, DY; Lemere, CA; Ma, Z; Peng, Y; Schachter, SC | 2 |
| Chu, DF; Fu, XQ; Li, YX; Liu, K; Liu, WH | 1 |
| Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA | 1 |
| Sivaprakasam, K | 1 |
| Liu, L; Wang, J; Xie, GY; Zhao, WJ | 1 |
| Beier, MT | 1 |
| Chen, D; Ding, P; Gao, P; Gao, Q; Sun, J; Xu, H | 1 |
| Tan, RX | 1 |
| Fu, XD; Gao, YL; Ping, QN | 1 |
| Jiang, XH; Lan, K; Li, YX; Wang, L | 1 |
| Eckert, S; Eyer, P; Worek, F | 1 |
| Caballero, J; Fernández, M | 1 |
| Wang, G; Zhan, H; Zhang, SQ | 1 |
| Delannay, E; Nuzillard, JM; Plé, K; Renault, JH; Richard, B; Toribio, A; Zèches-Hanrot, M | 1 |
| Badia, A; Camps, P; Clos, MV; Curutchet, C; Gómez, E; Luque, FJ; Muñoz-Muriedas, J; Muñoz-Torrero, D | 1 |
| Badia, A; Camps, P; Clos, MV; Colombo, L; Muñoz-Torrero, D; Pera, M; Ratia, M; Román, S; Salmona, M | 1 |
| Darvesh, S; Duysen, EG; Li, B; Lockridge, O | 1 |
| Kelly, SA; Lucey, C; Mann, J | 1 |
| Chen, QH; Tao, T; Yue, P; Zhao, Y | 1 |
| Chai, X; Ren, J; Tao, T; Yue, P; Zhao, Y | 2 |
| Tang, XC; Wang, ZF | 1 |
| Chen, QH; Dong, WX; Tao, T; Yue, P; Zhao, Y | 1 |
| Haviv, H; Silman, I; Sussman, JL; Wong, DM | 1 |
| Fu, F; Liu, J; Liu, K; Ma, H; Wang, C; Zhang, T | 1 |
| Cheng, XR; Zhang, YX; Zhou, WX | 1 |
| Jin, GX; Tong, Y; Wang, XP; Wang, XY; Yao, SM; Zhang, ZJ | 1 |
| Chu, D; Li, Y; Li, Z; Liu, W; Tian, J | 1 |
| Huang, XT; Liang, YQ; Tang, XC | 1 |
| Gang, DR; Ma, X; Tan, C; Xiao, P; Zhu, D | 1 |
| Chen, SN; Kleps, R; Kozikowski, AP; Laatikainen, R; Niemitz, M; Pauli, GF | 1 |
| Carlier, PR; Han, YF; Kan, KK; Li, WM; Pang, YP | 1 |
| Hu, Q; Li, J; Li, W | 1 |
| Chen, X; Li, GC; Talbot, SG; Xiao, J; Xu, M; Zhang, L | 1 |
| Aisen, PS; Little, JT; Walsh, S | 1 |
| Chen, HW; Luo, GJ; Wang, G; Zhan, H; Zhang, SQ | 1 |
| Chen, GS; Ye, JC; Zeng, S; Zheng, GL | 1 |
| Armstrong, EJ; Hemendinger, RA; Mougeot, JL; Persinski, R; Rosenfeld, J; Todd, J; Volvovitz, F | 1 |
| Wang, DS; Zhao, JK | 1 |
| Dong, BR; Li, J; Liu, GJ; Wu, HM; Zhou, RL | 1 |
| Tang, XC; Zhang, HY; Zheng, CY | 1 |
| Tang, XC; Wang, J; Wang, ZF; Zhang, HY | 1 |
| Gao, X; Tang, LL; Tang, XC; Wang, ZF; Yan, H; Zhang, HY; Zheng, CY | 1 |
| Aisen, PS; Doctor, BP; Garcia, GE; Gordon, RK; Haigh, JR; Johnston, SR; Mattern, PJ; Peppernay, A | 1 |
| Coleman, BR; Doctor, BP; Gordon, RK; Nambiar, MP; Oguntayo, SA; Ratcliffe, RH; Shi, X | 1 |
| Al-Abed, Y; Chavan, S; Ochani, K; Ochani, M; Parrish, WR; Pavlov, VA; Puerta, M; Rosas-Ballina, M; Tracey, KJ | 1 |
| Auta, J; Costa, E; Guidotti, A; Kadriu, B; Kozikowski, AP; Pibiri, F; Pinna, G | 1 |
| An, JJ; Cheng, JF; Jiang, Y; Li, HJ; Li, P; Zhou, JL | 1 |
| Chen, HZ; Song, YY; Wang, BS; Wang, H; Wei, ZH; Zhang, L | 1 |
| Desilets, AR; Dunican, KC; Gickas, JJ | 1 |
| Chen, XQ; Cheng, X; He, J; Li, MM; Peng, LY; Wang, YP; Xie, MJ; Xu, G; Zhao, QS; Zhao, Y; Zheng, YT | 1 |
| Gao, X; Tang, XC; Yang, L; Zhang, HY; Zheng, CY | 1 |
| Hao, Z; Liu, M; Liu, Z; Lv, D | 1 |
| Tang, XC; Wang, J; Zhang, HY | 2 |
| Dodman, NH; Faissler, D; Ogata, N; Schneider, BM | 1 |
| Cao, H; Wen, J; Xu, M; Zhang, L | 1 |
| Li, Z; Luo, H; Qiu, M; Sun, L; Wu, G; Yan, J; Yang, F; Yang, X; Yi, P; Zhang, X; Zhou, L | 1 |
| Chen, WL; Chu, NN; Li, XN; Liu, GY; Xu, HR; Yu, C; Zhang, XL | 1 |
| Adler, M; Akkerman, M; Albuquerque, EX; Aracava, Y; Pereira, EF | 1 |
| Chen, G; Wang, Q | 1 |
| Fukuyama, T; Koshiba, T; Yokoshima, S | 1 |
| He, F; Liu, C; Tang, Y; Yang, D; Zhou, W | 1 |
| Bonvillain, AJ; Clark, MG; Doctor, BP; Myers, TM; Saxena, A; Sun, W | 1 |
| Park, P; Schachter, S; Yaksh, T | 1 |
| de Kanter, FJ; Giera, M; Irth, H; Lingeman, H; Marques, LA; Niessen, WM | 1 |
| Chen, DW; Hu, HY; Li, KX; Li, L; Sun, X; Yang, CR; Zhao, XL | 1 |
| Wang, J; Yan, R; Zeng, Q; Zhang, Z; Zhu, D | 1 |
| Liu, Q; Luo, G; Shi, J; Wang, Y | 1 |
| Field, AR; Goodger, JQ; Holtum, JA; Lim, WH; Woodrow, IE | 1 |
| Hannongbua, S; Kitisripanya, N; Saparpakorn, P; Wolschann, P | 1 |
| Wang, LY; Wang, Y; Yan, RM; Zeng, QG; Zhang, ZB; Zhu, D | 1 |
| Gale, K; Kozikowski, AP; Malkova, L | 1 |
| Teng, WP; Wang, CY; Wang, SL; Wang, T; Wang, ZY; Xie, JW; Zhao, BL; Zheng, W | 1 |
| Aisen, PS; Behan, K; Jin, S; Little, JT; Rafii, MS; Reynolds, B; Thomas, R; Walsh, S; Ward, C | 1 |
| Carlier, PR; Choi, CL; Cui, GZ; Cui, W; Han, Y; Hu, S; Lee, SM; Li, W; Mak, S; Wong, YT; Zhang, H; Zhang, Z | 1 |
| Gurkas, E; Orhan, G; Orhan, IE | 1 |
| Ha, GT; Wong, RK; Zhang, Y | 1 |
| Doctor, BP; Jensen, N; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y | 1 |
| Jiang, XJ; Liang, XM; Xu, ZQ; Zhang, YF; Zhu, CX | 1 |
| Tang, XC; Wang, Y; Zhang, HY | 1 |
| Cong, W; Liu, Q; Luo, G; Shi, J; Wang, Y | 1 |
| Bandouchova, H; Pikula, J; Pohanka, M; Zemek, F | 1 |
| Chen, NH; Dai, JG; Hu, JF; Ning, N; Yuan, YH; Zhang, XY | 1 |
| Bandouchova, H; Drtinova, L; Hrabinova, M; Pikula, J; Pohanka, M; Zemek, F | 1 |
| Kapnissi-Christodoulou, CP; Moore, L; Nicolaou, IN; Tsioupi, DA | 1 |
| Cuthbertson, D; Lange, BM; Piljac-Žegarac, J | 1 |
| Aisen, PS; Cummings, J; Schneider, LS | 1 |
| Liu, W; Naik, RS; Saxena, A | 1 |
| Chen, F; Deng, W; Liu, W; Peng, B; Wang, J; Wang, R; Wang, Y; Wu, G; Yuan, J; Zhao, H; Zheng, P | 1 |
| Huang, XT; Tang, XC; Yang, L; Ye, CY; Zhang, HY | 1 |
| Cai, X; Jiang, Y; Li, Z; Luan, Y; Shao, W; Song, A; Zhao, Z | 1 |
| Gao, G; Guo, W; Liu, S; Peng, J; Qiu, Y; Sun, Y; Wang, P; Wei, X; Xu, Y | 1 |
| Badia, A; Camps, P; Clos, MV; Giménez-Llort, L; Muñoz-Torrero, D; Pérez, B; Ratia, M | 1 |
| Diao, T; Fu, J; Ge, D; He, Y; Liu, Z; Lu, Y; Ran, J; Shi, Q; Wei, J | 1 |
| Calderón, AI; Espinosa, A; Gupta, MP; Sanchez, R; Simithy-Williams, J; Valdespino, I | 1 |
| Kuang, P; Liang, H; Wang, Y; Yuan, Q; Zhang, H | 1 |
| Ding, R; Lin, GQ; Sun, BF | 1 |
| Zhang, HY | 1 |
| Cabrera, JL; Gonçalves, CA; Henriques, AT; Konrath, EL; Lunardi, PS; Neves, BM; Ortega, MG; Passos, Cdos S | 1 |
| Shen, JN; Wang, DS; Wang, R | 1 |
| Doctor, BP; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y | 1 |
| Hill, F; Koza, MM; Masson, P; Nachon, F; Peters, J; Tehei, M; Trapp, M; Trovaslet, M; van Eijck, L; Weik, M | 1 |
| Liu, S; Lu, L; Wu, J; Ye, W; Zhang, X | 1 |
| Dong, BR; Lin, X; Wu, HM; Wu, T; Yang, M; Yue, J | 1 |
| Chen, HZ; Cui, Y; Ge, XX; Li, J; Liu, T; Qiu, ZB; Wang, H; Xia, Z; Xie, Q; Xu, J; Xu, JR; Zhang, WW | 1 |
| Chandrashankra, O; Hu, Y; Ip, FC; Ip, NY; Zhang, J | 1 |
| Bao, Z; Gao, Z; Hu, X; Kong, D; Liu, F; Ruan, Q; Shi, D; Yu, Z | 1 |
| Lok, K; Lu, J; Nie, H; Shen, H; Wang, Y; Wang, Z; Xu, Z; Yin, M; Zhang, C; Zhao, W | 1 |
| Aisa, HA; Dou, J; Wu, T; Zhao, Y | 1 |
| Burshtein, G; Friedman, M; Greenberg, S; Hoffman, A | 1 |
| Kim, J; Li, Y; Terinek, M; White, JD | 2 |
| Han, I; Haragopal, H; Ropper, AE; Schachter, SC; Sidman, RL; Teng, YD; Thakor, DK; Yu, D; Zafonte, R | 1 |
| Doctor, BP; Gunosewoyo, H; Kozikowski, AP; Nambiar, MP; Pieroni, M; Tipparaju, SK; Wang, Y | 1 |
| Abib, R; Gonçalves, CA; Guerra, MC; Leite, MC; Lunardi, P; Nardin, P | 1 |
| Cesario, A; Del Bufalo, A; Fini, M; Frustaci, A; Russo, P | 1 |
| Kalaria, DR; Kalia, YN; Patel, PA; Patil, SC; Patravale, VB | 1 |
| Fang, L; Jiang, H; Tao, Y; Yang, H; Yang, Y; Zhang, H; Zhou, H | 1 |
| Bai, F; Chen, J; Gu, J; Jiang, H; Li, H; Liu, Q; Ma, J; Onuchic, JN; Wang, X; Xu, Y | 1 |
| Gong, K; Gong, Y; Ma, T; Tang, P; Yan, Y; Zhang, L; Zhang, X | 1 |
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| Ahmed, N; Ahn, Y; Cosoveanu, A; Shu, S; Wang, J; Wang, M; Wang, W; Xia, Q; Zhang, G; Zhang, X; Zhao, X | 1 |
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| Li, X; Liu, ZQ; Mao, XY; Zhou, HH | 1 |
| Breitbach, ZS; Kapnissi-Christodoulou, CP; Stavrou, IJ | 1 |
| Altintas, O; Antar, V; Baran, GE; Baran, O; Erdogan, H; Tasdemiroglu, E; Yuceli, S | 1 |
| Hao, H; Lu, C; Sun, M; Wang, M | 1 |
| Feng, ZH; Li, XY; Liu, L; Mei, SH; Wang, M; Wang, Y; Wang, YJ; Zuo, ZX | 1 |
| Hou, B; Yang, H; Zhang, S; Zuo, Z | 1 |
| Damar, U; Gersner, R; Johnstone, JT; Rotenberg, A; Schachter, S | 2 |
| Hu, CY; Jia, JY; Li, XN; Liu, GY; Liu, Y; Lu, C; Qu, Y; Sheng, L; Wang, HY; Wang, WL; Wang, YJ; Xu, HR; Yan, J; Yu, C; Zhang, MQ | 1 |
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| Chen, YT; Huang, XT; Tang, XC; Tao, LX; Zhang, HY | 1 |
| Chen, Y; Fu, Y; Gong, Y; Jiang, C; Wang, Z; Xie, L; Yi, X | 1 |
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| Fan, Z; Li, X; Wu, S; Xiao, Y; Xu, B; Yang, M; You, W; Zhu, M | 1 |
| Du, Y; Fu, F; Liang, H; Zhang, L | 1 |
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| Mei, Z; Situ, B; Tan, X; Wang, Y; Zheng, P | 1 |
| Cui, R; Li, X; Ruan, H; Sun, J; Tian, L | 1 |
| Collins, S; Damar, U; Gersner, R; Johnstone, JT; Kapur, K; Rotenberg, A; Schachter, S | 1 |
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| Andrés, J; Nascimento, ÉCM; Oliva, M | 1 |
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| Hirose, D; Ishiuchi, K; Jiang, WP; Kitanaka, S; Makino, T; Monthakantirat, O; Nakayama, W; Suzuki, T; Wu, JB | 1 |
| Grubmüller, H; Jakubowski, R; Nowak, W; Rydzewski, J | 1 |
| Peng, S; Wang, Y; Yan, R; Yang, H; Zhang, Z | 1 |
| Chen, T; Hu, L; Kang, X; Liu, D; Shen, P; Zhang, J | 1 |
| Han, Q; Han, Y; Huang, L; Huang, W; Liu, X; Xie, D; Zeng, H; Zhu, S | 1 |
| Fan, YX; Liu, YT; Luo, YH; Wang, LJ; Wen, J; Yan, PW; Zhang, Q; Zhu, HF | 1 |
| Lee, KW; Park, C; Rampogu, S; Son, M; Zeb, A | 1 |
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| Feng, S; Guo, YH; Hu, J; Huang, P; Li, B; Liu, QQ | 1 |
| Ahmed, AS; Al-Hagar, OEA; El-Shatoury, EH; Zaki, AG | 2 |
| Baum, L; Fei, Z; Hong, T; Hu, M; Kwan, P; Zhang, C | 1 |
| Bonjoch, J; Bosch, C; Bradshaw, B | 1 |
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| Cheng, X; Deng, G; Ding, W; Guan, H; Ju, Z; Li, S; Liu, W; Ma, C; Rong, X; Wang, C; Wang, Y; Wu, C | 1 |
| Mao, W; Shan, WG; Tang, QY; Tong, CP; Xu, YL; Ying, YM; Yu, HF; Zhan, ZJ; Zhang, CX; Zhang, Y; Zhang, ZD | 1 |
| Chen, S; Chen, Y; Cheng, G; Fang, W; Gao, S; Hu, R; Lu, W; Nie, X; Shen, Q; Sun, C; Wang, B; Xia, H | 1 |
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| Bai, LG; Cao, F; Han, C; Jian, MM; Ma, ZY; Xu, Y; Yang, K | 1 |
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| Cosoveanu, A; Cui, L; Liu, J; Liu, Y; Noushahi, HA; Shu, S; Yan, L; Zhang, J; Zhang, Y | 1 |
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55 review(s) available for huperzine a and sesquiterpenes
| Article | Year |
|---|---|
[Intelligence promoting Chinese materia medica].
Topics: Alkaloids; Animals; Drugs, Chinese Herbal; Intelligence; Learning; Memory; Sesquiterpenes | 1995 |
Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Rats; Sesquiterpenes; Stereoisomerism | 1993 |
Huperzine A (shuangyiping): a promising drug for Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Humans; Learning; Memory; Sesquiterpenes | 1996 |
Huperzine A--an interesting anticholinesterase compound from the Chinese herbal medicine.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Humans; Sesquiterpenes | 1998 |
[Huperzine a: an acetylcholinesterase inhibitor with high pharmacological potential].
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Humans; Neuroprotective Agents; Sesquiterpenes | 1999 |
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine | 2000 |
Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease.
Topics: Acetylcholine; Alkaloids; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Cognition; Drugs, Chinese Herbal; Haplorhini; Humans; Rats; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship | 2000 |
Huperzine A.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Contraindications; Memory; Rats; Sesquiterpenes | 2000 |
Dementia research in China.
Topics: Alkaloids; Caregivers; China; Cross-Cultural Comparison; Dementia; Drug Evaluation; Epidemiologic Studies; Humans; Incidence; Medicine, East Asian Traditional; Neuroprotective Agents; Prevalence; Risk Factors; Sesquiterpenes; Survival Rate | 2000 |
Review of the value of huperzine as pretreatment of organophosphate poisoning.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Organophosphate Poisoning; Sesquiterpenes | 2002 |
Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Drug Design; Humans; Models, Molecular; Molecular Conformation; Sesquiterpenes; Structure-Activity Relationship; Tacrine | 2001 |
Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.
Topics: Alkaloids; Alzheimer Disease; Estrogens, Non-Steroidal; Galantamine; Humans; Isoflavones; Physostigmine; Phytoestrogens; Phytotherapy; Plant Extracts; Plant Preparations; Plants, Medicinal; Sesquiterpenes | 2003 |
[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Topics: Alkaloids; Cholinesterase Inhibitors; Donepezil; Indans; Molecular Conformation; Molecular Structure; Piperidines; Sesquiterpenes; Tacrine | 2002 |
The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Clinical Trials as Topic; Humans; Neuroprotective Agents; Nootropic Agents; Phytotherapy; Plant Extracts; Psychopharmacology; Sesquiterpenes | 2003 |
Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease.
Topics: Alkaloids; Animals; Clinical Trials as Topic; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Sesquiterpenes; Structure-Activity Relationship | 2003 |
Huperzine A.
Topics: Alkaloids; Alzheimer Disease; Animals; Drugs, Investigational; Humans; Nootropic Agents; Sesquiterpenes | 2004 |
Recent pharmacological studies on natural products in China.
Topics: Alkaloids; Animals; Benzofurans; Berberine; China; Cholinesterase Inhibitors; Diterpenes; Dopamine Agonists; Dopamine Antagonists; Drugs, Chinese Herbal; Epoxy Compounds; Ginkgo biloba; Humans; Immunosuppressive Agents; Lactams; Lignans; Neuroprotective Agents; Phenanthrenes; Rutaceae; Sesquiterpenes | 2004 |
The Lycopodium alkaloids.
Topics: Alkaloids; Cholinesterase Inhibitors; Lycopodium; Molecular Structure; Sesquiterpenes; Structure-Activity Relationship | 2004 |
[Advances on study of organophosphate poisoning prevented by Huperzine A].
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Guinea Pigs; Macaca mulatta; Mice; Organophosphate Poisoning; Poisoning; Rats; Sesquiterpenes | 2005 |
Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Brain Chemistry; Cell Death; Cerebrovascular Disorders; Cholinesterase Inhibitors; Humans; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Signal Transduction | 2005 |
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
Topics: Alkaloids; Alzheimer Disease; Animals; Apoptosis; Brain; Cholinesterase Inhibitors; Cholinesterases; Cognition; Dementia, Vascular; Humans; Neuroprotective Agents; Oxidative Stress; Sesquiterpenes | 2006 |
Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation.
Topics: Alkaloids; Alzheimer Disease; Amyloid; Cholinergic Fibers; Cholinesterase Inhibitors; Galantamine; Inflammation; Neurofibrillary Tangles; Plaque, Amyloid; Receptors, Nicotinic; Sesquiterpenes | 2006 |
Harmless herbs? Think again: merits of a complete medication history.
Topics: Aged; Alkaloids; Cholinesterase Inhibitors; Dementia; Evidence-Based Medicine; Galantamine; Geriatric Assessment; Geriatrics; Ginkgo biloba; Herb-Drug Interactions; Humans; Medical History Taking; Neuroprotective Agents; Nootropic Agents; Phytotherapy; Sesquiterpenes | 2006 |
Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Ligands; Models, Molecular; Molecular Structure; Sesquiterpenes; Torpedo | 2007 |
Huperzine A from Huperzia species--an ethnopharmacolgical review.
Topics: Alkaloids; Alzheimer Disease; China; Cholinesterase Inhibitors; Clinical Trials as Topic; Europe; Humans; Huperzia; Medicine, Chinese Traditional; Plants, Medicinal; Sesquiterpenes | 2007 |
Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Humans; Neuroprotective Agents; Sesquiterpenes | 2008 |
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Drugs, Chinese Herbal; Humans; Models, Biological; Sesquiterpenes; Tacrine | 2007 |
An update on huperzine A as a treatment for Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Humans; Neuroprotective Agents; Sesquiterpenes | 2008 |
[Progress of study on treatment of Alzheimer's disease with active ingredients of Chinese herbal medicines].
Topics: Alkaloids; Alzheimer Disease; Drugs, Chinese Herbal; Ginkgo biloba; Ginsenosides; Humans; Phytotherapy; Salvia miltiorrhiza; Sesquiterpenes | 2008 |
Huperzine A for Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Randomized Controlled Trials as Topic; Sesquiterpenes | 2008 |
Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Dementia, Vascular; Humans; Sesquiterpenes | 2008 |
Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis.
Topics: Activities of Daily Living; Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Regression Analysis; Sesquiterpenes; Treatment Outcome | 2009 |
Role of huperzine a in the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Humans; Neuroprotective Agents; Sesquiterpenes | 2009 |
Huperzine A for vascular dementia.
Topics: Alkaloids; Dementia, Vascular; Drugs, Chinese Herbal; Humans; Neuroprotective Agents; Sesquiterpenes | 2009 |
Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
Topics: Acetylcholine; Alkaloids; Animals; Anti-Inflammatory Agents; Cholinergic Agents; Cholinesterase Inhibitors; Dementia, Vascular; Disease Models, Animal; Donepezil; Galantamine; Humans; Indans; Inflammation; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, Cholinergic; Rivastigmine; Sesquiterpenes; Signal Transduction | 2009 |
An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Galantamine; Humans; Huperzia; Liliaceae; Sesquiterpenes | 2011 |
Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials as Topic; Humans; Neuroprotective Agents; Sesquiterpenes | 2011 |
Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.
Topics: Alkaloids; Alzheimer Disease; Amino Acids; Animals; Cholinesterase Inhibitors; Dietary Supplements; Disease Progression; Docosahexaenoic Acids; Donepezil; Drug Approval; Galantamine; Ginkgo biloba; Half-Life; History, 20th Century; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Psychotropic Drugs; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Sesquiterpenes; Vitamin B Complex; Vitamin E | 2012 |
Huperzine A for mild cognitive impairment.
Topics: Alkaloids; Cholinesterase Inhibitors; Cognitive Dysfunction; Humans; Neuroprotective Agents; Sesquiterpenes | 2012 |
Multitarget drugs of plants origin acting on Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Biological Products; Cholinesterase Inhibitors; Crocus; Drug Discovery; Galantamine; Galanthus; Ginkgo biloba; Humans; Huperzia; Neuroprotective Agents; Physostigmine; Plant Extracts; Plants; Salvia; Sesquiterpenes | 2013 |
Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials.
Topics: Alkaloids; Alzheimer Disease; Humans; Placebos; Publication Bias; Randomized Controlled Trials as Topic; Risk Factors; Sesquiterpenes | 2013 |
Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research.
Topics: Alkaloids; Animals; Anticonvulsants; Cholinesterase Inhibitors; Epilepsy; Humans; Neuroprotective Agents; Sesquiterpenes | 2016 |
Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis.
Topics: Alkaloids; Antipsychotic Agents; Cognition Disorders; Drug Therapy, Combination; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Schizophrenia; Sesquiterpenes | 2016 |
Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review.
Topics: Abietanes; Alkaloids; Alzheimer Disease; Curcuma; Curcumin; Drugs, Chinese Herbal; Epimedium; Evodia; Flavonoids; Ginsenosides; Humans; Huperzia; Panax; Phytotherapy; Plant Extracts; Quinazolines; Salvia miltiorrhiza; Scutellaria baicalensis; Sesquiterpenes | 2016 |
[Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis].
Topics: Alkaloids; Cognitive Dysfunction; Humans; Memory; Randomized Controlled Trials as Topic; Sesquiterpenes | 2019 |
Microbial acetylcholinesterase inhibitors for Alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery.
Topics: Alkaloids; Alzheimer Disease; Animals; Bacteria; Cholinesterase Inhibitors; Drug Delivery Systems; Fermentation; Humans; Mice; Nanostructures; Nanotechnology; Sesquiterpenes | 2020 |
Slow-binding inhibitors of acetylcholinesterase of medical interest.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Humans; Myasthenia Gravis; Nervous System Diseases; Protein Binding; Sesquiterpenes; Tocopherols | 2020 |
Research on endophytic fungi for producing huperzine A on a large-scale.
Topics: Alkaloids; Endophytes; Fermentation; Fungi; Huperzia; Industrial Microbiology; Sesquiterpenes | 2020 |
The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews.
Topics: Activities of Daily Living; Alkaloids; Alzheimer Disease; Cognitive Dysfunction; Dementia; Humans; Quality of Life; Sesquiterpenes; Systematic Reviews as Topic | 2021 |
Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Drug Combinations; Drug Delivery Systems; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Sesquiterpenes; Tacrine | 2021 |
Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Humans; Huperzia; Molecular Structure; Neuroprotective Agents; Sesquiterpenes; Signal Transduction | 2021 |
A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies-Emphasis on Alzheimer's Disease Pathogenesis.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Humans; Sesquiterpenes | 2022 |
Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease.
Topics: Activities of Daily Living; Alkaloids; Alzheimer Disease; Ginkgolides; Humans; Neurodegenerative Diseases; Plant Extracts; Sesquiterpenes | 2022 |
Delineating biosynthesis of Huperzine A, A plant-derived medicine for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Huperzia; Sesquiterpenes | 2022 |
Disease-Modifying Activity of Huperzine A on Alzheimer's Disease: Evidence from Preclinical Studies on Rodent Models.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Rodentia; Sesquiterpenes | 2022 |
14 trial(s) available for huperzine a and sesquiterpenes
| Article | Year |
|---|---|
[Drug evaluation of huperzine A in the treatment of senile memory disorders].
Topics: Aged; Alkaloids; Case-Control Studies; Cholinesterase Inhibitors; Dementia; Dementia, Multi-Infarct; Double-Blind Method; Female; Humans; Male; Memory Disorders; Middle Aged; Sesquiterpenes | 1991 |
Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Behavior; Cholinesterase Inhibitors; Cognition; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Prospective Studies; Sesquiterpenes; Tablets | 1995 |
Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students.
Topics: Adolescent; Adult; Alkaloids; Capsules; Cholinesterase Inhibitors; Double-Blind Method; Female; Humans; Learning; Male; Matched-Pair Analysis; Memory; Sesquiterpenes; Wechsler Scales | 1999 |
Huperzine-A in capsules and tablets for treating patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Capsules; Cholinesterase Inhibitors; Double-Blind Method; Female; Humans; Lipid Peroxides; Male; Middle Aged; Prospective Studies; Sesquiterpenes; Superoxide Dismutase; Tablets | 1999 |
[Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial].
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Sesquiterpenes | 2002 |
[Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia].
Topics: Acetylcholine; Aged; Alkaloids; Anesthesia Recovery Period; Anesthesia, General; Brain; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Double-Blind Method; Electrochemistry; Female; Humans; Intraoperative Period; Male; Sesquiterpenes | 2006 |
Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.
Topics: Adolescent; Adult; Aged; Alkaloids; Antipsychotic Agents; Chlorpromazine; Cholinesterase Inhibitors; Clozapine; Drug Resistance; Drug Synergism; Female; Humans; Male; Middle Aged; Risperidone; Schizophrenia; Sesquiterpenes | 2007 |
Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
Topics: Acetylcholinesterase; Administration, Oral; Aged; Alkaloids; Butyrylcholinesterase; Dose-Response Relationship, Drug; Erythrocytes; Humans; Sesquiterpenes; Soman | 2008 |
A phase II trial of huperzine A in mild to moderate Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Analysis of Variance; Apolipoproteins E; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Mental Status Schedule; Middle Aged; Neuroprotective Agents; Sesquiterpenes; Time Factors; Treatment Outcome | 2011 |
Treatment with Huperzine A improves cognition in vascular dementia patients.
Topics: Activities of Daily Living; Aged; Alkaloids; Ascorbic Acid; Cognition; Dementia, Vascular; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Placebo Effect; Sesquiterpenes; Severity of Illness Index | 2012 |
Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Cross-Over Studies; Double-Blind Method; Humans; Male; Prodrugs; Sesquiterpenes; Treatment Outcome; Young Adult | 2013 |
Safety and Preliminary Efficacy of the Acetylcholinesterase Inhibitor Huperzine A as a Treatment for Cocaine Use Disorder.
Topics: Administration, Intravenous; Administration, Oral; Adult; Alkaloids; Blood Pressure; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Male; Self Administration; Sesquiterpenes; Treatment Outcome | 2015 |
Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects.
Topics: Aged; Aged, 80 and over; Aging; Alkaloids; Asian People; Body Height; Body Weight; Creatinine; Female; Humans; Male; Middle Aged; Models, Biological; Nonlinear Dynamics; Sesquiterpenes; Sex Characteristics | 2016 |
Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease.
Topics: Aged; Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Dysfunction; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Sesquiterpenes | 2019 |
358 other study(ies) available for huperzine a and sesquiterpenes
| Article | Year |
|---|---|
Mechanism of inhibition of cholinesterases by huperzine A.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Stability; Horses; Humans; Kinetics; Paraoxon; Protein Binding; Recombinant Proteins; Sesquiterpenes; Torpedo | 1992 |
Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.
Topics: Alkaloids; Animals; Brain; Cholinesterase Inhibitors; In Vitro Techniques; Models, Molecular; Molecular Conformation; Rats; Sesquiterpenes; Structure-Activity Relationship | 1991 |
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase.
Topics: Alkaloids; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Kinetics; Rats; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship | 1991 |
Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Chemical Phenomena; Chemistry, Physical; Cholinesterase Inhibitors; Crystallization; Humans; Molecular Conformation; Molecular Structure; Sesquiterpenes; X-Ray Diffraction | 1991 |
Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Physostigmine; Rats; Rats, Inbred Strains; Sesquiterpenes | 1991 |
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Animals; Binding, Competitive; Cholinergic Fibers; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Male; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Sesquiterpenes | 1989 |
[Effects of huperzine A on electroencephalography power spectrum in rabbits].
Topics: Alkaloids; Animals; Electroencephalography; Male; Physostigmine; Rabbits; Scopolamine; Sesquiterpenes; Signal Processing, Computer-Assisted | 1989 |
[Anti-cholinesterase activity of huperzine A].
Topics: Alkaloids; Animals; Caudate Nucleus; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Cholinesterases; Erythrocyte Membrane; Rats; Sesquiterpenes; Swine | 1986 |
[Effects of huperzine A on learning and the retrieval process of discrimination performance in rats].
Topics: Alkaloids; Animals; Atropine; Discrimination Learning; Hemicholinium 3; Male; Memory; Physostigmine; Rats; Scopolamine; Sesquiterpenes | 1986 |
[Effects of huperzine A and B on skeletal muscle and the electroencephalogram].
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electroencephalography; Mice; Muscle Contraction; Rabbits; Rats; Sesquiterpenes | 1987 |
[Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment].
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Discrimination Learning; Female; Lighting; Male; Memory; Physostigmine; Rats; Sesquiterpenes | 1988 |
[Effects of huperzine A on cholinesterase isoenzymes in plasma of mice and dogs].
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Cholinesterases; Dogs; Female; Isoenzymes; Male; Mice; Sesquiterpenes | 1988 |
[Pharmacokinetics of huperzine A in rats and mice].
Topics: Alkaloids; Animals; Biological Availability; Cholinesterase Inhibitors; Female; Male; Maternal-Fetal Exchange; Mice; Pregnancy; Rats; Sesquiterpenes; Tissue Distribution | 1988 |
[Improvement of impaired memory in mice by huperzine A and huperzine B].
Topics: Alkaloids; Animals; Avoidance Learning; Cholinesterase Inhibitors; Female; Male; Memory; Mice; Retention, Psychology; Sesquiterpenes | 1988 |
[Facilitatory effects of huperzine A and B on learning amd memory of spatial discrimination in mice].
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Discrimination Learning; Male; Memory; Mice; Physostigmine; Sesquiterpenes | 1987 |
Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines.
Topics: Acetylcholine; Alkaloids; Animals; Biogenic Amines; Cerebral Cortex; Cholinesterase Inhibitors; Dopamine; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Sodium Chloride; Time Factors | 1995 |
Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Cholinesterase Inhibitors; Dementia; Drug Evaluation; Male; Mice; Rats; Scopolamine; Sesquiterpenes; Structure-Activity Relationship | 1995 |
Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies.
Topics: Acetylcholinesterase; Algorithms; Alkaloids; Binding Sites; Cholinesterase Inhibitors; Computer-Aided Design; Drug Design; Electrochemistry; Hydrogen Bonding; In Vitro Techniques; Models, Molecular; Molecular Conformation; Molecular Structure; Sesquiterpenes; Software; Thermodynamics | 1994 |
Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.
Topics: Acetylcholinesterase; Alkaloids; Amino Acids; Animals; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Electrochemistry; Humans; Hydrogen Bonding; Kinetics; Mice; Models, Molecular; Recombinant Proteins; Sesquiterpenes; Stereoisomerism; Thermodynamics; Torpedo | 1994 |
Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism | 1994 |
Effect of cholinesterase inhibition in vitro by huperzine analogs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Erythrocyte Membrane; Galantamine; Physostigmine; Rats; Sesquiterpenes; Structure-Activity Relationship | 1994 |
[Facilitation of cholinergic transmission by huperzine A in toad paravertebral ganglia in vitro].
Topics: Acetylcholine; Action Potentials; Alkaloids; Animals; Bufo bufo; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; In Vitro Techniques; Sesquiterpenes; Synaptic Transmission | 1994 |
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Binding Sites; Brain; Cholinesterase Inhibitors; Injections, Intraperitoneal; Kinetics; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Physostigmine; Poisoning; Sesquiterpenes; Soman; Time Factors | 1994 |
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Cell Line; Cholinesterase Inhibitors; Humans; Hydrogen-Ion Concentration; Mutation; Sesquiterpenes; Tyrosine | 1994 |
Huperzine A ameliorates the spatial working memory impairments induced by AF64A.
Topics: Alkaloids; Analysis of Variance; Animals; Aziridines; Choline; Cholinesterase Inhibitors; Injections, Intraventricular; Male; Maze Learning; Memory Disorders; Neurotoxins; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 1995 |
Pharmacokinetics of tablet huperzine A in six volunteers.
Topics: Adult; Alkaloids; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Female; Humans; Male; Sesquiterpenes; Tablets | 1995 |
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Topics: Acetylcholinesterase; Alkaloids; Crystallography, X-Ray; Nootropic Agents; Protein Binding; Protein Conformation; Sesquiterpenes | 1997 |
Huperzine A, a novel promising acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1996 |
Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials as Topic; Drug Design; Drugs, Chinese Herbal; Drugs, Investigational; Fever; Humans; Sesquiterpenes | 1997 |
Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholinesterase; Alkaloids; Animals; Calcium; Cell Death; Cell Survival; Cells, Cultured; Embryo, Mammalian; Glutamic Acid; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Prosencephalon; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 1997 |
Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality.
Topics: Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Hippocampus; Male; Neuroprotective Agents; Pyridostigmine Bromide; Receptors, N-Methyl-D-Aspartate; Seizures; Sesquiterpenes; Soman | 1997 |
Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands.
Topics: Acetophenones; Acetylcholinesterase; Acylation; Alkaloids; Binding Sites; Binding, Competitive; Cholinesterase Inhibitors; Enzyme Activation; Humans; Hydrolysis; Ligands; Models, Chemical; Propidium; Sesquiterpenes | 1998 |
Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Cattle; Cholinesterase Inhibitors; Magnetic Resonance Spectroscopy; Male; Neuromuscular Junction; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spectrophotometry, Infrared; Tacrine | 1998 |
Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities.
Topics: Alkaloids; Animals; Aziridines; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Injections, Intraventricular; Male; Maze Learning; Memory; Memory, Short-Term; Neuromuscular Blocking Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1998 |
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Chemical; Models, Molecular; Physostigmine; Protein Conformation; Pyridostigmine Bromide; Sesquiterpenes; Structure-Activity Relationship; Tacrine | 1998 |
Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity.
Topics: Acetylcholine; Acetylcholinesterase; Action Potentials; Alkaloids; Animals; Butyrylcholinesterase; Choline; Cholinesterase Inhibitors; Dogs; Electrophysiology; Ganglia, Autonomic; Heart; Humans; Hydrolysis; Kinetics; Neurons; Parasympatholytics; Phenothiazines; Sesquiterpenes; Substrate Specificity | 1998 |
Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; In Vitro Techniques; Indans; Male; Mice; Neuromuscular Junction; Piperidines; Sesquiterpenes; Synaptic Transmission; Taurine | 1996 |
Interpreting the effect of methyl group at the three carbon bridge of (-)-huperzine A on its anticholinesterase activity by molecular dynamics method.
Topics: Alkaloids; Cholinesterase Inhibitors; Hydrogen Bonding; Sesquiterpenes; Structure-Activity Relationship | 1998 |
Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.
Topics: Alkaloids; Animals; Catalysis; Catechols; Cattle; Cholinesterase Inhibitors; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Palladium; Phenols; Pyridones; Sesquiterpenes; Structure-Activity Relationship | 1998 |
Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment.
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Cognition Disorders; Conditioning, Operant; Drug Interactions; Female; Macaca mulatta; Male; Memory Disorders; Memory, Short-Term; Neuroprotective Agents; Psychomotor Performance; Scopolamine; Sesquiterpenes | 1999 |
An analysis of low level doses of cholinesterase inhibitors in cultured neurons and hippocampal slices of rats.
Topics: Alkaloids; Animals; Cells, Cultured; Cholinesterase Inhibitors; Culture Techniques; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Neurons; Organophosphorus Compounds; Organothiophosphorus Compounds; Patch-Clamp Techniques; Rats; Sarin; Sesquiterpenes; Tetrodotoxin | 1998 |
Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.
Topics: Action Potentials; Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; Indans; Male; Membrane Potentials; Mice; Muscle Fibers, Skeletal; Neuromuscular Junction; Phrenic Nerve; Piperidines; Sesquiterpenes; Tacrine | 1997 |
Mouse acetylcholinesterase unliganded and in complex with huperzine A: a comparison of molecular dynamics simulations.
Topics: Acetylcholinesterase; Alkaloids; Animals; Catalytic Domain; Ligands; Mice; Models, Molecular; Protein Conformation; Sesquiterpenes; Thermodynamics | 1999 |
Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit.
Topics: Alkaloids; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Kainic Acid; Male; Maze Learning; Physostigmine; Rats; Rats, Sprague-Dawley; Retention, Psychology; Sesquiterpenes; Substantia Innominata | 1998 |
Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance.
Topics: Acetylcholinesterase; Alkaloids; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Erythrocyte Membrane; Female; Male; Maze Learning; Memory; Mice; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 1998 |
Molecular dynamics of mouse acetylcholinesterase complexed with huperzine A.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Computer Simulation; Mice; Models, Molecular; Sesquiterpenes | 1999 |
Modulation of NMDA receptor by huperzine A in rat cerebral cortex.
Topics: Alkaloids; Animals; Cell Separation; Cerebral Cortex; Cholinesterase Inhibitors; Dizocilpine Maleate; Hippocampus; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Synaptic Membranes | 1999 |
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Animals; Binding Sites; Cholinesterase Inhibitors; Diaphragm; In Vitro Techniques; Male; Models, Molecular; Muscle Contraction; Neuromuscular Junction; Neuroprotective Agents; Phrenic Nerve; Quinolines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine; Torpedo | 1999 |
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Sesquiterpenes; Tacrine | 1999 |
Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury.
Topics: Alkaloids; Animals; Catalase; Cell Survival; Cholinesterase Inhibitors; Glutathione Peroxidase; Hydrogen Peroxide; Lipid Peroxidation; Malondialdehyde; Models, Neurological; PC12 Cells; Rats; Sesquiterpenes | 1999 |
Suppressive action produced by beta-amyloid peptide fragment 31-35 on long-term potentiation in rat hippocampus is N-methyl-D-aspartate receptor-independent: it's offset by (-)huperzine A.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Neuroprotective Agents; Peptide Fragments; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes | 1999 |
Predicting relative binding free energies of tacrine-huperzine A hybrids as inhibitors of acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Amino Acid Substitution; Animals; Cholinesterase Inhibitors; Neuroprotective Agents; Protein Binding; Sesquiterpenes; Tacrine; Thermodynamics; Torpedo | 1999 |
Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Hippocampus; In Vitro Techniques; Indans; Neuroprotective Agents; Nootropic Agents; Piperidines; Rats; Sesquiterpenes | 1999 |
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
Topics: Acetylcholinesterase; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Donepezil; Edrophonium; Hydrogen Bonding; Indans; Ligands; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Structure, Secondary; Reproducibility of Results; Sesquiterpenes; Static Electricity; Torpedo; Water | 2000 |
[Pretreatment of organophosphate poisoning: potential interests of huperzine A].
Topics: Alkaloids; Antidotes; Cholinesterase Inhibitors; Humans; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Sesquiterpenes | 2000 |
Treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Drug Therapy, Combination; Humans; Sesquiterpenes | 2000 |
Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Catalase; Cell Survival; Cholinesterase Inhibitors; Glutathione Peroxidase; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Sesquiterpenes; Superoxide Dismutase | 2000 |
Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Brain Ischemia; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cognition Disorders; Glucose; Lactates; Lipid Peroxides; Male; Maze Learning; Neurons; Proteins; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Superoxide Dismutase | 2000 |
Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Catalase; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Glutathione Peroxidase; Lipid Peroxidation; Malondialdehyde; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Rats, Wistar; Sesquiterpenes; Superoxide Dismutase; Tacrine | 2000 |
Synthesis of 5-substituted analogues of huperzine A.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Inhibitory Concentration 50; Sesquiterpenes; Structure-Activity Relationship | 2000 |
Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.
Topics: Acetylcholine; Alkaloids; Animals; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glutamic Acid; Humans; Kinetics; Molecular Structure; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Sesquiterpenes; Stereoisomerism | 2000 |
Similar potency of the enantiomers of huperzine A in inhibition of [(3)H]dizocilpine (MK-801) binding in rat cerebral cortex.
Topics: Alkaloids; Alzheimer Disease; Animals; Binding Sites; Cerebral Cortex; Cholinesterase Inhibitors; Dizocilpine Maleate; Drug Interactions; Neurons; Neuroprotective Agents; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Stereoisomerism; Synaptic Membranes | 2000 |
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Bridged Bicyclo Compounds; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Humans; In Vitro Techniques; Male; Mice; Models, Molecular; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Neuroprotective Agents; Quinolines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine; Tubocurarine | 2000 |
Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss.
Topics: Alkaloids; Beverages; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Molecular Structure; Plant Extracts; Sesquiterpenes | 2000 |
Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-D-aspartate receptors.
Topics: Acetylcholine; Alkaloids; Animals; Bicuculline; Cholinesterase Inhibitors; Electric Stimulation; GABA Antagonists; Hippocampus; Long-Term Potentiation; Muscarinic Antagonists; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Scopolamine; Sesquiterpenes | 2001 |
Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats.
Topics: Aging; Alkaloids; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Free Radicals; Hippocampus; Lipid Peroxidation; Male; Malondialdehyde; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Superoxide Dismutase | 1999 |
Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance.
Topics: Aging; Alkaloids; Animals; Cholinesterase Inhibitors; Male; Maze Learning; Memory; Memory Disorders; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes | 2000 |
Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells.
Topics: Alkaloids; Animals; Astrocytoma; Brain Neoplasms; Diterpenes; Dose-Response Relationship, Drug; Ginkgolides; Glioma; Humans; Lactones; Neuroprotective Agents; Nitric Oxide; Rats; Sesquiterpenes; Tumor Cells, Cultured | 1999 |
Effects of Huperzine used as pre-treatment against soman-induced seizures.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Electroencephalography; Kinetics; Male; Microdialysis; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Sesquiterpenes; Soman | 2001 |
Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Evans Blue; Guinea Pigs; Male; Microscopy, Fluorescence; Neuroprotective Agents; Physostigmine; Pyridostigmine Bromide; Serum Albumin; Sesquiterpenes | 2001 |
Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Electroencephalography; Guinea Pigs; Male; Neuroprotective Agents; Physostigmine; Pyridostigmine Bromide; Scopolamine; Seizures; Sesquiterpenes; Soman; Time Factors | 2001 |
Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
Topics: Alkaloids; Alzheimer Disease; Animals; Cell Size; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Glucose; Hypoxia-Ischemia, Brain; Indans; Lipid Peroxidation; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Rats; Sesquiterpenes; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2001 |
Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation.
Topics: Alkaloids; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Hypoxia; DNA Fragmentation; Gene Expression; Genes, bcl-2; Genes, jun; Genes, p53; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Sesquiterpenes | 2001 |
Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Apoptosis; bcl-2-Associated X Protein; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Dose-Response Relationship, Drug; Hippocampus; Humans; In Situ Nick-End Labeling; Infusion Pumps; Injections, Intraventricular; Male; Maze Learning; Memory Disorders; Microscopy, Electron; Nerve Degeneration; Neurons; Neuroprotective Agents; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tumor Suppressor Protein p53 | 2001 |
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermine; Zinc | 2001 |
Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells.
Topics: Alkaloids; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Cholinesterase Inhibitors; Cytoprotection; Gene Expression Regulation; Hydrogen Peroxide; Immunohistochemistry; Neuroprotective Agents; Oxidants; PC12 Cells; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Tumor Suppressor Protein p53 | 2001 |
Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick.
Topics: Alkaloids; Amnesia; Animals; Avoidance Learning; Chickens; Cholinesterase Inhibitors; GABA Agonists; Male; Muscarinic Antagonists; Muscimol; Retention, Psychology; Scopolamine; Sesquiterpenes | 2000 |
Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Animals; Choline O-Acetyltransferase; Cognition Disorders; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Memory Disorders; Neurons; Reaction Time; Sesquiterpenes | 2001 |
Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Coumarins; Cysteine Proteinase Inhibitors; Drug Interactions; Female; Fetus; Flow Cytometry; Neurons; Oligopeptides; Peptide Fragments; Pregnancy; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2002 |
Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Female; Macaca mulatta; Memory; Reserpine; Sesquiterpenes; Yohimbine | 2001 |
Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice.
Topics: Acetylcholine; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Mice; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Peptide Fragments; Rats; Sesquiterpenes; Stereoisomerism | 2002 |
Insecticidal activity of huperzine A from the New Zealand clubmoss, Lycopodium varium.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Coleoptera; Diptera; Insecticides; Lycopodiaceae; Moths; New Zealand; Sesquiterpenes | 2002 |
Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.
Topics: Alkaloids; Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Cholinesterase Inhibitors; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermidine; Synaptic Membranes | 2002 |
Effects of chronic administration of huperzine A on memory in guinea pigs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Guinea Pigs; Male; Maze Learning; Memory; Sesquiterpenes | 2002 |
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Binding Sites; Chlorine; Cholinesterase Inhibitors; Computer Simulation; Crystallization; Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Kinetics; Ligands; Models, Molecular; Protein Conformation; Sesquiterpenes; Species Specificity; Tacrine; Torpedo | 2002 |
The NMDA receptor ion channel: a site for binding of Huperzine A.
Topics: Alkaloids; Animals; Binding Sites; Blood-Brain Barrier; Cerebral Cortex; Culture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Guinea Pigs; Ion Channels; Ligands; N-Methylaspartate; Neuroprotective Agents; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes | 2001 |
Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.
Topics: Acetylcholine; Alkaloids; Alzheimer Disease; Animals; Animals, Newborn; Cells, Cultured; Cholinesterase Inhibitors; Hippocampus; Humans; Neural Inhibition; Neurons; Neuroprotective Agents; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Synaptic Transmission | 2002 |
Have you had your moss today?
Topics: Aged; Alkaloids; Drugs, Chinese Herbal; Humans; Neuroprotective Agents; Sesquiterpenes | 2002 |
Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons.
Topics: Alkaloids; Animals; Dose-Response Relationship, Drug; Hippocampus; Membrane Potentials; Neural Inhibition; Neurons; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2002 |
Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Macaca fascicularis; Male; Pyridostigmine Bromide; Seizures; Sesquiterpenes; Soman | 2002 |
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
Topics: Acetylcholinesterase; Alkaloids; Animals; Binding, Competitive; Bryopsida; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Drugs, Chinese Herbal; Ligands; Macromolecular Substances; Protein Binding; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Torpedo | 2002 |
Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons.
Topics: Alkaloids; Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; DNA Fragmentation; Mitochondria; Neurons; Neuroprotective Agents; Rats; Sesquiterpenes | 2002 |
Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia.
Topics: Alkaloids; Animals; Animals, Newborn; Brain Injuries; Carotid Arteries; Cerebral Cortex; Cholinesterase Inhibitors; Cognition; Corpus Striatum; Dose-Response Relationship, Drug; Female; Hippocampus; Hypoxia-Ischemia, Brain; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Water | 2002 |
Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.
Topics: Alkaloids; Apoptosis; Brain Neoplasms; Cell Division; Diterpenes; Flow Cytometry; Ginkgolides; Humans; Lactones; Neuroblastoma; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Sesquiterpenes; Tumor Cells, Cultured | 2002 |
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine | 2002 |
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Kinetics; Ligands; Models, Molecular; Sesquiterpenes; Species Specificity; Structure-Activity Relationship; Torpedo | 2003 |
Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.
Topics: Alkaloids; Animals; Antibodies; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Enzyme Inhibitors; Male; Microsomes, Liver; Phenacetin; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2003 |
Acute effects of huperzine A and tacrine on rat liver.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Cholinesterase Inhibitors; Female; Hepatocytes; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 2003 |
Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons.
Topics: Alkaloids; Animals; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Embryo, Mammalian; Female; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Staurosporine | 2003 |
Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids.
Topics: Alkaloids; Aminoquinolines; Animals; Brain; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine | 2003 |
Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases.
Topics: Alkaloids; Amidohydrolases; Cholinesterases; Enzyme Activation; Enzyme Inhibitors; Humans; Sesquiterpenes; Stereoisomerism | 2003 |
Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection.
Topics: Alkaloids; Biological Products; Chromatography, High Pressure Liquid; Huperzia; Plant Extracts; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Spectrum Analysis | 2003 |
Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle.
Topics: Acetylcholine; Alkaloids; Animals; Cholinesterase Inhibitors; Diaphragm; Drug Synergism; Guinea Pigs; Humans; Ileum; Iris; Muscle, Smooth; Muscles; Neuromuscular Junction; Phrenic Nerve; Physostigmine; Rana catesbeiana; Rats; Rectus Abdominis; Sesquiterpenes | 2003 |
Effects of huperzine A on liver cytochrome P-450 in rats.
Topics: Alkaloids; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Male; Microsomes, Liver; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sesquiterpenes; Steroid 16-alpha-Hydroxylase | 2003 |
Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.
Topics: Acetylcholinesterase; Alkaloids; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cholinesterase Inhibitors; DNA Fragmentation; Mice; Neuroblastoma; Neuroprotective Agents; Peptide Fragments; Sesquiterpenes; Tumor Cells, Cultured | 2003 |
[Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase].
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Erythrocyte Membrane; Molecular Conformation; Molecular Structure; Rats; Sesquiterpenes | 2003 |
A convergent approach to huperzine A and analogues.
Topics: Alkaloids; Cholinesterase Inhibitors; Cyclization; Cyclohexanones; Isomerism; Sesquiterpenes | 2003 |
Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A.
Topics: Alkaloids; Alkylation; Binding Sites; Cholinesterase Inhibitors; Indicators and Reagents; Polymers; Protein Conformation; Sesquiterpenes; Tacrine | 2003 |
[Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats].
Topics: Acetylcholinesterase; Alkaloids; Animals; Animals, Newborn; Cerebral Cortex; Cognition Disorders; Corpus Striatum; Female; Hippocampus; Hypoxia-Ischemia, Brain; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Treatment Outcome | 2003 |
[Pharmacodynamic action of annotine and selagine].
Topics: Alkaloids; Autonomic Agents; Sesquiterpenes | 1952 |
1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Huperzia; Hydrogen; Magnetic Resonance Spectroscopy; Sesquiterpenes; Torpedo | 2004 |
A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Chromatography, Liquid; Male; Rats; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization | 2004 |
Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma.
Topics: Alkaloids; Animals; Dogs; Mass Spectrometry; Neuroprotective Agents; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes | 2004 |
Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells.
Topics: Alkaloids; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line; Humans; Injections, Intraventricular; Male; Mutation; Peptide Fragments; Protein Kinase C; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2004 |
Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain Chemistry; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fasciculation; Indans; Male; Neurons; Phenylcarbamates; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Up-Regulation | 2004 |
Selagoline, a new alkaloid from Huperzia selago.
Topics: Alkaloids; Cholinesterase Inhibitors; Huperzia; Magnetic Resonance Spectroscopy; Sesquiterpenes; Spectroscopy, Fourier Transform Infrared | 2004 |
Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.
Topics: Adenosine Triphosphatases; Alkaloids; Analysis of Variance; Aniline Compounds; Animals; Behavior, Animal; Brain Chemistry; Calcium; Carbohydrates; Cell Count; Cell Death; Cell Line; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Escape Reaction; Glutathione Peroxidase; Hippocampus; Humans; Male; Mannans; Maze Learning; Memory Disorders; Muscarinic Antagonists; Neuroprotective Agents; Oligosaccharides; Rats; Rats, Wistar; Reaction Time; Scopolamine; Sesquiterpenes; Superoxide Dismutase; Swimming; Time Factors; Xanthenes | 2005 |
(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
Topics: Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Animals, Newborn; Apoptosis; Cerebellum; Cholinesterase Inhibitors; Colchicine; Cytoskeleton; Disease Models, Animal; Flow Cytometry; Glycogen Synthase Kinase 3; Heterocyclic Compounds, 4 or More Rings; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 2004 |
Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Dogs; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Spectrophotometry, Ultraviolet | 2005 |
Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China.
Topics: Alkaloids; China; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Humidity; Huperzia; Neuroprotective Agents; Seasons; Sensitivity and Specificity; Sesquiterpenes | 2005 |
Huperzine A--human serum albumin association: chromatographic and thermodynamic approach.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Humans; Serum Albumin; Sesquiterpenes; Thermodynamics | 2005 |
Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.
Topics: Acetylcholinesterase; Alkaloids; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Huperzia; Nerve Growth Factor; Neurites; Neuroprotective Agents; PC12 Cells; Plants, Medicinal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sesquiterpenes | 2005 |
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Topics: Alkaloids; Animals; Avoidance Learning; Behavior, Animal; Brain Diseases; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Memory; Mice; Peptide Fragments; Scopolamine; Sesquiterpenes; Tacrine | 2006 |
Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres.
Topics: Alkaloids; Biocompatible Materials; Cholinesterase Inhibitors; Drug Compounding; Hot Temperature; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Molecular Weight; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sesquiterpenes; Solvents | 2005 |
Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
Topics: Alkaloids; Androstadienes; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Immunohistochemistry; Indole Alkaloids; Nerve Growth Factor; Neuroblastoma; Neuroprotective Agents; Oxidants; Oxidative Stress; Protein Kinase Inhibitors; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Wortmannin | 2005 |
Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks.
Topics: Alkaloids; Electrophoresis, Capillary; Humans; Neural Networks, Computer; Reproducibility of Results; Sesquiterpenes; Ultraviolet Rays | 2005 |
Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Desiccation; Dogs; Drug Compounding; Drug Stability; Lactic Acid; Microscopy, Electron, Scanning; Microspheres; Neuroprotective Agents; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sesquiterpenes; Solubility; Water | 2005 |
A survey of potential huperzine A natural resources in China: the Huperziaceae.
Topics: Alkaloids; China; Conservation of Natural Resources; Data Collection; Humans; Huperzia; Plant Structures; Plants, Medicinal; Sesquiterpenes | 2006 |
Preparation and in vivo evaluation of huperzine A-loaded PLGA microspheres.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2005 |
How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations.
Topics: Acetylcholinesterase; Alkaloids; Animals; Binding Sites; Hydrogen Bonding; Models, Molecular; Protein Binding; Protein Conformation; Sesquiterpenes; Time Factors; Torpedo; Water | 2003 |
Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
Topics: Acetylcholine; Alkaloids; Aminoquinolines; Animals; Atropine; Cholinesterase Inhibitors; Dopamine Antagonists; Dose-Response Relationship, Drug; Galantamine; Haloperidol; Heterocyclic Compounds, 4 or More Rings; In Vitro Techniques; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Parasympatholytics; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sesquiterpenes | 2005 |
Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
Topics: Administration, Oral; Alkaloids; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Humans; Neuroprotective Agents; Pyridostigmine Bromide; Sesquiterpenes; Soman | 2005 |
Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.
Topics: Acetylcholine; Adaptation, Ocular; Alkaloids; Animals; Behavior, Animal; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Cloning, Molecular; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Perciformes; Phylogeny; Pigment Epithelium of Eye; Pigments, Biological; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Analysis, Protein; Sesquiterpenes | 2005 |
Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Alkaloids; Animals; Calibration; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dogs; Female; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sesquiterpenes; Spectrophotometry, Ultraviolet | 2006 |
Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Huperzia; Mass Spectrometry; Molecular Structure; Neuroprotective Agents; Reproducibility of Results; Sesquiterpenes; Spectrophotometry, Ultraviolet | 2006 |
A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Molecular Conformation; Molecular Structure; Neuroprotective Agents; Nitriles; Sesquiterpenes; Silicon Dioxide; Solvents | 2005 |
In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid).
Topics: Alkaloids; Animals; Drug Compounding; Injections, Subcutaneous; Lactic Acid; Male; Microscopy, Electron, Scanning; Microspheres; Neuroprotective Agents; Particle Size; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Sesquiterpenes; Viscosity | 2006 |
Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases.
Topics: Alkaloids; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Chromatography; Chromatography, High Pressure Liquid; Kinetics; Membranes, Artificial; Models, Chemical; Models, Theoretical; Pharmaceutical Preparations; Sesquiterpenes; Silanes; Software; Technology, Pharmaceutical | 2006 |
Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres.
Topics: Alkaloids; Alzheimer Disease; Delayed-Action Preparations; Drug Compounding; Humans; Lactic Acid; Microscopy, Confocal; Microscopy, Electron, Scanning; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sesquiterpenes | 2005 |
Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.
Topics: Adenosine Triphosphate; Alkaloids; Amyloid beta-Peptides; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Fluorometry; Microscopy, Electron; Mitochondria; Neuroprotective Agents; PC12 Cells; Peptides; Rats; Reactive Oxygen Species; Sesquiterpenes; Sodium-Potassium-Exchanging ATPase | 2006 |
Application of L-Amino acid in determination of Huperzine A by high performance liquid chromatography.
Topics: Alkaloids; Amino Acids; Chromatography, High Pressure Liquid; Reference Standards; Sensitivity and Specificity; Sesquiterpenes; Spectrophotometry, Ultraviolet | 2006 |
Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice.
Topics: Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Gene Expression Regulation; Hippocampus; Ischemic Attack, Transient; Male; MAP Kinase Signaling System; Memory Disorders; Mice; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factor; Nerve Growth Factors; Neuroprotective Agents; Phosphorylation; Reperfusion; Sesquiterpenes; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Models, Molecular; Protein Binding; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Tacrine | 2006 |
Acetylcholinesterase triggers the aggregation of PrP 106-126.
Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Cattle; Cholinesterase Inhibitors; Coumarins; Heterocyclic Compounds, 4 or More Rings; Humans; Microscopy, Fluorescence; Peptide Fragments; Prions; Propidium; Protein Structure, Secondary; Sesquiterpenes | 2006 |
Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations.
Topics: Administration, Oral; Alkaloids; Animals; Area Under Curve; Cholinesterase Inhibitors; Dogs; Female; Injections, Intravenous; Male; Neuroprotective Agents; Sesquiterpenes | 2006 |
Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.
Topics: Acetylcholinesterase; Algorithms; Alkaloids; Carbamates; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Erythrocytes; Humans; Kinetics; Organophosphorus Compounds; Paraoxon; Physostigmine; Pyridostigmine Bromide; Sesquiterpenes; Time Factors | 2006 |
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
Topics: Aged; Alkaloids; Alzheimer Disease; Brain; Caregivers; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Diagnostic and Statistical Manual of Mental Disorders; Galantamine; Geriatric Psychiatry; Health Services for the Aged; Humans; Phenylcarbamates; Professional-Family Relations; Rivastigmine; Sesquiterpenes; Tacrine; United States | 2006 |
[Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Insecticides; Malathion; Male; Mice; Mice, Inbred Strains; Poisoning; Random Allocation; Sesquiterpenes | 2006 |
Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
Topics: Alkaloids; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Endopeptidases; Enzyme Inhibitors; Gene Expression; Humans; Hydroxamic Acids; Neuroprotective Agents; Protein Kinase C-alpha; Sesquiterpenes; Time Factors | 2006 |
Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs.
Topics: Alkaloids; Animals; Area Under Curve; Biological Availability; Cholinesterase Inhibitors; Chromatography, Liquid; Dogs; Drug Compounding; Female; Injections, Intramuscular; Injections, Subcutaneous; Lactic Acid; Male; Mass Spectrometry; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sesquiterpenes | 2006 |
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors | 2006 |
[Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim].
Topics: Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Insecticides; Malathion; Male; Mice; Neuroprotective Agents; Organothiophosphorus Compounds; Random Allocation; Sesquiterpenes | 2006 |
Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.
Topics: Acetylcholine; Administration, Oral; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Indans; Male; Neuroprotective Agents; Norepinephrine; Phenylcarbamates; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Rivastigmine; Serotonin; Sesquiterpenes | 2006 |
Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Calorimetry, Differential Scanning; Cerebral Cortex; Cholinesterase Inhibitors; Delayed-Action Preparations; Drug Stability; Lactic Acid; Male; Microscopy, Electron, Scanning; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Wistar; Sesquiterpenes | 2007 |
Editorial: natural products chemistry in China.
Topics: Alkaloids; Alzheimer Disease; Artemisinins; Biological Products; Malaria; Medicine, Chinese Traditional; Sesquiterpenes | 2006 |
[Effect of preparation technique on in vitro release mechanism of huperzine A microspheres].
Topics: Alkaloids; Cholinesterase Inhibitors; Drug Compounding; Lactic Acid; Microscopy, Confocal; Microscopy, Electron, Scanning; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sesquiterpenes | 2006 |
Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Cholinesterase Inhibitors; Humans; Neuroprotective Agents; Sesquiterpenes | 2006 |
Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Humans; Huperzia; Mass Spectrometry; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes | 2007 |
Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
Topics: Acetylcholinesterase; Alkaloids; Carbamates; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Humans; In Vitro Techniques; Sesquiterpenes; Soman; Time Factors | 2007 |
Ensembles of Bayesian-regularized genetic neural networks for modeling of acetylcholinesterase inhibition by huprines.
Topics: Acetylcholinesterase; Algorithms; Alkaloids; Animals; Bayes Theorem; Cattle; Cholinesterase Inhibitors; Computer Simulation; Drug Design; Models, Biological; Molecular Structure; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Sesquiterpenes; Tacrine | 2006 |
Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography.
Topics: Alkaloids; Centrifugation; Countercurrent Distribution; Huperzia; Hydrogen-Ion Concentration; Sesquiterpenes | 2007 |
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Topics: Acetylcholinesterase; Alkaloids; Aminoquinolines; Animals; Anions; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Erythrocytes; Formamides; Glycine; Heterocyclic Compounds, 4 or More Rings; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Tacrine | 2006 |
Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Kinetics; Peptide Fragments; Prions; Scrapie; Sesquiterpenes | 2006 |
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; Chlorpyrifos; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Mice; Mice, Knockout; Neurotoxicity Syndromes; Piperidines; Sesquiterpenes; Synaptic Transmission | 2007 |
A concise and convergent (formal) total synthesis of huperzine A.
Topics: Alkaloids; Chemistry, Organic; Chemistry, Pharmaceutical; Enzyme Inhibitors; Hydrolysis; Ketones; Models, Chemical; Sesquiterpenes; Solvents; Stereoisomerism | 2007 |
Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats.
Topics: Administration, Intranasal; Alkaloids; Animals; Area Under Curve; Brain; Chromatography, High Pressure Liquid; Gels; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2007 |
Huperzine A in rat plasma and CSF following intranasal administration.
Topics: Administration, Intranasal; Alkaloids; Animals; Area Under Curve; Biological Availability; Blood-Brain Barrier; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Injections, Intravenous; Intubation, Gastrointestinal; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spectrometry, Fluorescence | 2007 |
Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.
Topics: Acetylcholinesterase; Alkaloids; Animals; Bungarotoxins; Cell Hypoxia; Cell Nucleus; Cell Survival; Cyclooxygenase 2; Glioma; Glucose; I-kappa B Proteins; Mecamylamine; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Proline; Protein Transport; Rats; Sesquiterpenes; Thiocarbamates; Transcription Factor RelA | 2007 |
[Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration].
Topics: Administration, Intranasal; Alkaloids; Animals; Area Under Curve; Biological Transport; Brain; Cattle; Cognition; Drug Compounding; Guinea Pigs; Injections, Intravenous; Male; Maze Learning; Mice; Models, Biological; Nasal Mucosa; Neuroprotective Agents; Particle Size; Polysaccharides, Bacterial; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sesquiterpenes | 2006 |
Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Avoidance Learning; Cerebral Cortex; Delayed-Action Preparations; Drug Carriers; Lactic Acid; Male; Memory Disorders; Mice; Microspheres; Muscarinic Antagonists; Neuroprotective Agents; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Reaction Time; Scopolamine; Sesquiterpenes; Spectrophotometry | 2007 |
The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.
Topics: Aging; Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; DNA, Complementary; Drugs, Chinese Herbal; Gene Expression Regulation; Hippocampus; Male; Mice; Mice, Inbred Strains; Phytotherapy; Plant Extracts; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Sesquiterpenes | 2007 |
Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector.
Topics: Absorption; Administration, Intranasal; Alkaloids; Animals; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Ethanolamines; Freezing; Half-Life; Metabolic Clearance Rate; Methanol; Molecular Structure; Neuroprotective Agents; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Spectrometry, Fluorescence; Time Factors; Water | 2007 |
Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: in vitro and in vivo studies and the application in the treatment of the impaired memory of mice.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Lactic Acid; Memory Disorders; Mice; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sesquiterpenes | 2007 |
Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.
Topics: Alkaloids; Cell Line; Cholinesterase Inhibitors; Enzyme Inhibitors; Humans; Mecamylamine; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Nicotinic Antagonists; Protein Kinase C; Receptor, Muscarinic M1; Scopolamine; Serum Amyloid A Protein; Sesquiterpenes; Up-Regulation | 2007 |
Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.
Topics: Acetylcholine; Alkaloids; Amyloid beta-Peptides; Animals; Basal Nucleus of Meynert; Biogenic Monoamines; Choline; Dopamine; Injections; Neurotransmitter Agents; Norepinephrine; Peptides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2008 |
Complete (1)H NMR spectral fingerprint of huperzine A.
Topics: Alkaloids; Cholinesterase Inhibitors; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Protons; Sesquiterpenes; Stereoisomerism | 2007 |
Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
Topics: Alkaloids; Asian People; China; Humans; Molecular Structure; Reproducibility of Results; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Topics: ADAM Proteins; ADAM10 Protein; ADAM17 Protein; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Muscarinic Antagonists; Neuroblastoma; Neurons; Peptide Fragments; Phosphorylation; Protein Kinase C; Receptors, Muscarinic; Sesquiterpenes | 2007 |
Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method.
Topics: Acetylcholinesterase; Alkaloids; Animals; Catechin; Cholinesterase Inhibitors; Kinetics; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2008 |
[Effects of huperzine A on cognitive function of rats recovering from general anesthesia].
Topics: Alkaloids; Anesthesia, General; Animals; Cholinesterase Inhibitors; Cognition; Maze Learning; Propofol; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2008 |
Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs.
Topics: Administration, Cutaneous; Administration, Oral; Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Delayed-Action Preparations; Dogs; Drug Administration Schedule; Female; Male; Sesquiterpenes; Skin Absorption; Tablets; Time Factors | 2008 |
Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.
Topics: Alkaloids; Animals; Apoptosis; Aspartic Acid; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Drug Interactions; Enzyme Inhibitors; Hydrogen Peroxide; Ionophores; Motor Neurons; Neuroprotective Agents; Organ Culture Techniques; Oxidants; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spinal Cord; Staurosporine; Thapsigargin | 2008 |
Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.
Topics: Alkaloids; Animals; Brain; Infarction, Middle Cerebral Artery; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2008 |
Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Ischemic Attack, Transient; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2008 |
In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Huperzia; Molecular Structure; Sesquiterpenes; Tandem Mass Spectrometry | 2008 |
[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Body Temperature; Disease Models, Animal; Electroencephalography; Heart Rate; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Seizures; Sesquiterpenes; Status Epilepticus | 2008 |
Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.
Topics: Acetylcholinesterase; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Atropine Derivatives; Brain; Cholinesterase Inhibitors; Cytokines; Endotoxemia; Enzyme-Linked Immunosorbent Assay; Female; Galantamine; Injections, Intraperitoneal; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Parasympatholytics; Receptors, Nicotinic; Sesquiterpenes; Tumor Necrosis Factor-alpha; Vagotomy | 2009 |
The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
Topics: Alkaloids; Animals; Benzodiazepines; Cognition Disorders; Drug Therapy, Combination; Imidazoles; Isoflurophate; Lethal Dose 50; Locomotion; Male; Mice; Seizures; Sesquiterpenes | 2008 |
Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins.
Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Chromatography, Gel; Chromatography, Liquid; Equipment Design; Galantamine; Ligands; Mass Spectrometry; Peptide Library; Protein Binding; Proteins; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Structure-Activity Relationship | 2009 |
Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
Topics: Alkaloids; Anti-HIV Agents; Cholinesterase Inhibitors; Drugs, Chinese Herbal; HIV-1; Lycopodium; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Sesquiterpenes | 2009 |
Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.
Topics: Adenosine Triphosphate; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Death; Cell Respiration; Cholinesterase Inhibitors; Cytoprotection; Free Radicals; Huperzia; In Vitro Techniques; Male; Mitochondria; Oxidative Phosphorylation; Peptide Fragments; Phytotherapy; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2009 |
Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.
Topics: Alkaloids; Animals; Behavior, Animal; Blood Cell Count; Blood Chemical Analysis; Diptera; Dog Diseases; Dogs; Electrodiagnosis; Electroencephalography; Epilepsy, Complex Partial; Male; Neuroprotective Agents; Sesquiterpenes | 2009 |
Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Anticarcinogenic Agents; Antioxidants; Beverages; Brain; Catechin; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Neuroprotective Agents; Serum Albumin; Sesquiterpenes | 2009 |
Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Computer Simulation; Drug Design; Humans; Neuroprotective Agents; Protein Binding; Schiff Bases; Sesquiterpenes; Structure-Activity Relationship | 2009 |
Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.
Topics: Alkaloids; Area Under Curve; Calibration; Chromatography, Liquid; Drug Stability; Humans; Least-Squares Analysis; Matrines; Quinolizines; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Tandem Mass Spectrometry | 2009 |
Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Chemical Warfare Agents; Donepezil; Dose-Response Relationship, Drug; Galantamine; Guinea Pigs; Indans; Lethal Dose 50; Male; Phenylcarbamates; Piperidines; Poisoning; Rivastigmine; Sesquiterpenes; Soman; Time Factors; Toxicity Tests, Acute | 2009 |
Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats.
Topics: Administration, Intranasal; Alkaloids; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Infusions, Intravenous; Male; Mass Spectrometry; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tissue Distribution | 2009 |
Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.
Topics: Alkaloids; Animals; Carotid Artery Diseases; CD11b Antigen; Cell Hypoxia; Cell- and Tissue-Based Therapy; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Male; Maze Learning; Mitogen-Activated Protein Kinase Kinases; Myelin Sheath; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
Total synthesis of (-)-huperzine A.
Topics: Alkaloids; Cyclization; Molecular Structure; Sesquiterpenes; Stereoisomerism | 2009 |
[Release mechanism of huperzine-A swelling sustained-release tablets].
Topics: Alkaloids; Cellulose; Delayed-Action Preparations; Diffusion; Models, Biological; Polyethylene Glycols; Sesquiterpenes; Tablets | 2009 |
Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.
Topics: Acetylcholinesterase; Alkaloids; Animals; Behavior, Animal; Cholinesterase Inhibitors; Cognition; Macaca mulatta; Sesquiterpenes | 2010 |
Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.
Topics: Alkaloids; Analgesics; Animals; Atropine; Behavior, Animal; Catheterization; Dose-Response Relationship, Drug; Hot Temperature; Injections, Spinal; Male; Muscarinic Antagonists; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Time Factors | 2010 |
Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment.
Topics: Alkaloids; Biological Assay; Calibration; Cholinesterase Inhibitors; Chromatography, Liquid; Kinetics; Mass Spectrometry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Photochemical Processes; Reference Standards; Sesquiterpenes; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 2010 |
Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.
Topics: Alkaloids; Calorimetry, Differential Scanning; Drug Carriers; Lipids; Microscopy, Electron, Transmission; Nanostructures; Neuroprotective Agents; Particle Size; Sesquiterpenes | 2010 |
A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata.
Topics: Alkaloids; Ascomycota; China; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Huperzia; Phylogeny; Plant Leaves; Sesquiterpenes | 2010 |
Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Cerebral Cortex; Glutathione Peroxidase; Hippocampus; Lipid Peroxidation; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Superoxide Dismutase | 2010 |
Huperzine alkaloids from Australasian and southeast Asian Huperzia.
Topics: Alkaloids; Asia, Southeastern; Australasia; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Huperzia; Inflorescence; Isomerism; Plant Leaves; Plant Stems; Sesquiterpenes; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Cholinesterase Inhibitors; Galantamine; Hydrogen Bonding; Protein Binding; Sesquiterpenes | 2011 |
Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata.
Topics: Alkaloids; Ascomycota; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Endophytes; Fungi; Huperzia; Mass Spectrometry; Plant Leaves; Plant Roots; Plant Stems; Sesquiterpenes | 2011 |
The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.
Topics: Alkaloids; Animals; Benzothiadiazines; Cholinesterase Inhibitors; Cognition; Female; Humans; Macaca; Male; Memory; Neuroprotective Agents; Nootropic Agents; Pattern Recognition, Visual; Receptors, AMPA; Recognition, Psychology; Sesquiterpenes | 2011 |
Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; beta Catenin; Blood-Retinal Barrier; Bromodeoxyuridine; Cell Survival; Cholinesterase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Microscopy, Electron, Scanning; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurogenesis; Olfactory Bulb; Presenilin-1; RNA, Messenger; Sesquiterpenes; Signal Transduction; Transfection; Wnt Proteins | 2011 |
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
Topics: Acetylcholinesterase; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Differentiation; Cells, Cultured; Dendritic Cells; Dimerization; Neural Stem Cells; PC12 Cells; Quinolones; Rats; Receptors, Nicotinic; Sesquiterpenes | 2011 |
[+]-Huperzine A protects against soman toxicity in guinea pigs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Blood-Brain Barrier; Body Temperature; Chemical Warfare Agents; Cholinesterase Inhibitors; Guinea Pigs; Male; Neuroprotective Agents; Pyridostigmine Bromide; Seizures; Sesquiterpenes; Soman; Stereoisomerism | 2011 |
Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice.
Topics: Alkaloids; Amyloid beta-Protein Precursor; Animals; Dendritic Spines; HEK293 Cells; Humans; Mice; Mice, Transgenic; Neuroprotective Agents; Plaque, Amyloid; Presenilin-1; Sesquiterpenes; Signal Transduction; Synapses | 2012 |
Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.
Topics: Administration, Cutaneous; Alkaloids; Alzheimer Disease; Animals; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Therapy, Combination; Emulsions; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Skin Absorption; Time Factors; Transdermal Patch; Vasodilator Agents | 2012 |
Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.
Topics: Alanine Transaminase; Alkaloids; Alzheimer Disease; Animals; Apoptosis; Aspartate Aminotransferases; Biomarkers; Blood Glucose; Blood Urea Nitrogen; Brain; Caspase 3; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Glutathione Reductase; Guinea Pigs; Kidney; Liver; Models, Animal; Neuroprotective Agents; Oxidative Stress; Risk Assessment; Sesquiterpenes; Spleen; Thiobarbituric Acid Reactive Substances; Toxicity Tests | 2012 |
Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis.
Topics: Alkaloids; Animals; Antioxidants; Apoptosis; Cell Survival; HSP70 Heat-Shock Proteins; Humans; Malondialdehyde; Molecular Structure; Neuroprotective Agents; Nitric Oxide Donors; Nitroprusside; PC12 Cells; Quercetin; Rats; Reactive Oxygen Species; Sesquiterpenes | 2012 |
Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
Topics: Alkaloids; Animals; Antioxidants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; FMN Reductase; Glutathione Reductase; Guinea Pigs; Homeostasis; Models, Animal; Models, Biological; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Sesquiterpenes | 2011 |
Chiral separation of Huperzine A using CE - method validation and application in pharmaceutical formulations.
Topics: Alkaloids; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Limit of Detection; Reproducibility of Results; Sesquiterpenes; Sodium Acetate; Stereoisomerism; Surface-Active Agents; Technology, Pharmaceutical; Temperature | 2012 |
Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia.
Topics: Alkaloids; Chromatography, High Pressure Liquid; High-Throughput Screening Assays; Huperzia; Limit of Detection; Linear Models; Plant Extracts; Reproducibility of Results; Sesquiterpenes | 2012 |
Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.
Topics: Alkaloids; Animals; Animals, Laboratory; Chlorocebus aethiops; Cholinesterase Inhibitors; Cholinesterases; Dogs; Guinea Pigs; High-Throughput Screening Assays; Humans; Limit of Detection; Macaca fascicularis; Macaca mulatta; Mice; Mice, Inbred BALB C; Phenothiazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sesquiterpenes; Swine; Swine, Miniature | 2013 |
Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice.
Topics: Alkaloids; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Myelitis; Neuroprotective Agents; Primary Cell Culture; Sesquiterpenes; T-Lymphocytes | 2012 |
Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.
Topics: Acetylcholinesterase; Adenosine Triphosphate; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Mitochondria; Multienzyme Complexes; Mutation; Peptide Fragments; Presenilin-1; Sesquiterpenes | 2012 |
Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release.
Topics: Alkaloids; Animals; Delayed-Action Preparations; Drug Carriers; Drug Implants; Gels; Glycine max; Injections, Subcutaneous; Neuroprotective Agents; Phosphatidylcholines; Polyethylene Glycols; Polyglactin 910; Rabbits; Sesquiterpenes; Solubility; Static Electricity; Temperature; Time Factors | 2012 |
Examining the interactome of huperzine A by magnetic biopanning.
Topics: Alkaloids; Animals; Bacteriophages; Brain; Electron Transport; Gene Library; Magnetics; Magnetite Nanoparticles; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proton-Translocating ATPases; NADH Dehydrogenase; Neuroprotective Agents; Plant Extracts; Protein Binding; Proteins; Proteome; Sesquiterpenes | 2012 |
Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).
Topics: Alkaloids; Alzheimer Disease; Aminoquinolines; Animals; Brain Chemistry; Cerebral Cortex; Cognition Disorders; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Humans; Male; Maze Learning; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Sesquiterpenes | 2013 |
Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
Topics: Air Pressure; Alkaloids; Animals; Behavior, Animal; Biomarkers; Blotting, Western; Cognition Disorders; Decompression Sickness; Glutathione; Hippocampus; Hypoxia, Brain; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Maze Learning; Memory; Neuroprotective Agents; Oxidative Stress; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes; Superoxide Dismutase | 2012 |
Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors.
Topics: Alkaloids; Antioxidants; Cholinesterase Inhibitors; Chromatography, Thin Layer; Lycopodiaceae; Lycopodium; Mass Spectrometry; Panama; Plant Extracts; Sesquiterpenes | 2013 |
Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
Topics: Adsorption; Alkaloids; Chromatography, High Pressure Liquid; Huperzia; Plant Extracts; Sesquiterpenes; Trifluoroacetic Acid | 2012 |
An efficient total synthesis of (-)-huperzine A.
Topics: Alkaloids; Alkylation; Cyclization; Cyclohexane Monoterpenes; Lycopodium; Molecular Structure; Monoterpenes; Sesquiterpenes; Stereoisomerism | 2012 |
New insights into huperzine A for the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Drug Delivery Systems; Drugs, Chinese Herbal; Humans; Lycopodium; Mitochondria; Neuroprotective Agents; Sesquiterpenes | 2012 |
Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain; Cerebral Cortex; Cholinesterase Inhibitors; Hippocampus; Huperzia; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Phytotherapy; Plant Extracts; Sesquiterpenes | 2012 |
The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells.
Topics: Acetylcholinesterase; Alkaloids; Amyloid beta-Peptides; Animals; Blotting, Western; cdc42 GTP-Binding Protein; Cholinesterase Inhibitors; Cytoprotection; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Gene Expression Profiling; Gene Expression Regulation; GPI-Linked Proteins; Humans; Neurites; Neurons; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; PC12 Cells; Peptide Fragments; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RAC2 GTP-Binding Protein; Rats; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes | 2012 |
A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Guinea Pigs; Male; Neuroprotective Agents; Rats; Seizures; Sesquiterpenes; Soman; Stereoisomerism | 2013 |
Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart.
Topics: Acetylcholinesterase; Alkaloids; Catalytic Domain; Cholinesterase Inhibitors; Humans; Molecular Dynamics Simulation; Protein Binding; Recombinant Proteins; Sesquiterpenes; Thermodynamics | 2012 |
Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcholinesterase; Alkaloids; Animals; Apoptosis; Cholinesterase Inhibitors; Disease Models, Animal; Dopaminergic Neurons; Gene Expression Regulation, Enzymologic; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Parkinsonian Disorders; PC12 Cells; Rats; Sesquiterpenes; Substantia Nigra | 2013 |
Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Female; Humans; Kinetics; Male; Maze Learning; Memory Disorders; Meptazinol; Mice; Models, Molecular; Nootropic Agents; Scopolamine; Sesquiterpenes | 2013 |
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Drug Design; Indans; Molecular Structure; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Structure-Activity Relationship | 2013 |
The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats.
Topics: Aging; Alkaloids; Animals; Anti-Inflammatory Agents; Cellular Senescence; Cytokines; Galactose; Inflammation; Liver; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2013 |
New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Cell Line; Escape Reaction; Maze Learning; Mice; Mice, Transgenic; Nicotine; Nicotinic Agonists; Radioligand Assay; Reaction Time; Receptors, Nicotinic; Sesquiterpenes | 2013 |
Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam.
Topics: Alkaloids; Alzheimer Disease; Animals; Benzothiazoles; Biphenyl Compounds; Cell Survival; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Flavonols; Flowers; Free Radical Scavengers; Free Radicals; Gossypium; Inhibitory Concentration 50; Lipid Peroxidation; Oxidative Stress; PC12 Cells; Picrates; Plant Extracts; Rats; Sesquiterpenes; Sulfonic Acids | 2013 |
Transepithelial transport of a natural cholinesterase inhibitor, huperzine A, along the gastrointestinal tract: the role of ionization on absorption mechanism.
Topics: Alkaloids; Animals; Antipyrine; Biological Transport; Biological Transport, Active; Caco-2 Cells; Cholinesterase Inhibitors; Enterocytes; Gastrointestinal Tract; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Ions; Male; Membranes, Artificial; Metoprolol; Palmitoylcarnitine; Permeability; Rats; Rats, Wistar; Sesquiterpenes | 2013 |
A novel synthesis of (-)-huperzine A via tandem intramolecular aza-Prins cyclization-cyclobutane fragmentation.
Topics: Alkaloids; Cholinesterase Inhibitors; Cyclization; Cyclobutanes; Molecular Structure; Sesquiterpenes; Stereoisomerism | 2013 |
Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A.
Topics: Alkaloids; Animals; Behavior, Animal; Female; Pain; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spinal Cord Compression | 2013 |
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Guinea Pigs; Neuroprotective Agents; Sesquiterpenes; Soman; Survival Analysis | 2013 |
Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures.
Topics: Alkaloids; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Dementia; Hippocampus; Male; Nerve Growth Factors; Neuroprotective Agents; Rats; Rats, Wistar; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Sesquiterpenes; Tacrine | 2013 |
Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A.
Topics: Administration, Cutaneous; Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Drug Carriers; Drug Stability; Gels; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Maze Learning; Mice; Nanoparticles; Neuroprotective Agents; Particle Size; Rabbits; Rats; Rats, Wistar; Scopolamine; Sesquiterpenes; Skin; Skin Absorption; Skin Irritancy Tests; Viscosity | 2013 |
Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Databases, Protein; Down-Regulation; Mice; Neuroblastoma; Neuroprotective Agents; Peptide Fragments; Protein Interaction Maps; Proteomics; Sesquiterpenes; Signal Transduction; Tumor Suppressor Protein p53 | 2013 |
Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Drug Discovery; Humans; Kinetics; Protein Binding; Protein Folding; Sesquiterpenes | 2013 |
Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.
Topics: Alkaloids; Animals; Blotting, Western; Cell Differentiation; Cell Proliferation; Hippocampus; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Sesquiterpenes | 2013 |
Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; GPI-Linked Proteins; Injections, Intramuscular; Lactic Acid; Male; Memory; Microspheres; Particle Size; Peptide Fragments; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Technology, Pharmaceutical | 2013 |
Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Nucleus of Meynert; Cerebral Cortex; Electroencephalography; Electroencephalography Phase Synchronization; Excitatory Amino Acid Agonists; Hippocampus; Male; Maze Learning; Memory, Short-Term; Neural Pathways; Parasympathetic Nervous System; Psychomotor Performance; Rats; Rats, Wistar; Sesquiterpenes; Space Perception | 2013 |
Integrative proteomics.
Topics: Alkaloids; Animals; Databases, Factual; Gangliosides; Glycoproteins; HeLa Cells; Humans; Mass Spectrometry; Mice; Neuroprotective Agents; Phosphotransferases; Proteomics; Sesquiterpenes | 2013 |
Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026.
Topics: Alkaloids; Biomass; Carbon; Cholinesterase Inhibitors; Colletotrichum; Endophytes; Ethanol; Fermentation; Methanol; Microbial Viability; Mycelium; Sesquiterpenes; Temperature; Time Factors | 2013 |
The use of borneol as an enhancer for targeting aprotinin-conjugated PEG-PLGA nanoparticles to the brain.
Topics: Alkaloids; Alzheimer Disease; Animals; Aprotinin; Behavior, Animal; Brain; Camphanes; Endothelial Cells; Male; Maze Learning; Mice; Mice, Nude; Nanoconjugates; Neuroprotective Agents; Polyesters; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tissue Distribution | 2013 |
[Determination of Huperzine A in the extract of Huperzia serrata by high performance liquid chromatography].
Topics: Alkaloids; Chromatography, High Pressure Liquid; Huperzia; Plant Extracts; Sesquiterpenes | 2013 |
[Effect of Huperzine A on neural lesion of acute organophosphate poisoning in mice].
Topics: Alkaloids; Animals; Brain; Glutamic Acid; Malathion; Male; Mice; Neuroprotective Agents; Nitric Oxide Synthase Type I; Organophosphate Poisoning; Organothiophosphorus Compounds; Sesquiterpenes | 2013 |
The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
Topics: Acetic Acid; Alkaloids; Animals; Antioxidants; Cholinergic Neurons; Cholinesterase Inhibitors; Colitis; Colon; Cytokines; Female; Glutathione; Male; Malondialdehyde; Neuroimmunomodulation; NF-kappa B; Nicotinamide Phosphoribosyltransferase; Nicotine; Nicotinic Agonists; Peroxidase; Rats; Rats, Sprague-Dawley; Resistin; Sesquiterpenes | 2013 |
[Determination of huperzine A and semi-quantitative RT-PCR analysis of lysine decarboxylase gene in different parts of Huperzia serrata from western Hunan].
Topics: Alkaloids; Carboxy-Lyases; China; Gene Expression; Huperzia; Plant Leaves; Plant Roots; Plant Stems; Reverse Transcriptase Polymerase Chain Reaction; Sesquiterpenes | 2013 |
Controlled iontophoretic transport of huperzine A across skin in vitro and in vivo: effect of delivery conditions and comparison of pharmacokinetic models.
Topics: Alkaloids; Animals; Humans; In Vitro Techniques; Iontophoresis; Male; Rats; Rats, Wistar; Sesquiterpenes; Skin; Swine | 2013 |
Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cluster Analysis; DNA, Fungal; DNA, Ribosomal Spacer; Endophytes; Huperzia; Molecular Sequence Data; Phylogeny; Sequence Analysis, DNA; Sesquiterpenes; Trichoderma | 2014 |
Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti-apoptotic and anti-inflammatory mechanisms.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Creatine Kinase; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Interleukin-1beta; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocardial Infarction; Rats; Sesquiterpenes; Superoxide Dismutase; Transcription Factor RelA; Troponin T; Tumor Necrosis Factor-alpha | 2014 |
Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.
Topics: Alkaloids; Cyclohexane Monoterpenes; Drugs, Chinese Herbal; Lycopodium; Molecular Structure; Monoterpenes; Sesquiterpenes; Stereoisomerism | 2014 |
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Topics: ADAM Proteins; ADAM10 Protein; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Iron; Membrane Proteins; Mice; Mice, Transgenic; Neuroprotective Agents; Phosphorylation; Phytotherapy; Plaque, Amyloid; Receptors, Transferrin; Sesquiterpenes; tau Proteins | 2014 |
Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
Topics: Alkaloids; Animals; Blood Glucose; Body Weight; Brain-Derived Neurotrophic Factor; Caspase 3; Cognition Disorders; Cytokines; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Hippocampus; Male; Memory; Neuroprotective Agents; Oxidative Stress; Oxidoreductases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sesquiterpenes; Streptozocin | 2014 |
Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation.
Topics: Alkaloids; Alzheimer Disease; Ascomycota; Cell Extracts; Endophytes; Fermentation; Huperzia; Lysine; Microbial Viability; Secondary Metabolism; Sesquiterpenes | 2014 |
Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Catalysis; Cholinesterase Inhibitors; Enzyme Activation; Humans; Kinetics; Models, Chemical; Molecular Dynamics Simulation; Protein Binding; Sesquiterpenes; Statistics as Topic | 2014 |
Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways.
Topics: Alanine Transaminase; Alkaloids; Animals; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Caspase 3; Catalase; Disease Models, Animal; Glutathione; Hepatic Veins; Liver; Male; Malondialdehyde; Medicine, Chinese Traditional; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reperfusion Injury; Sesquiterpenes; Superoxide Dismutase | 2014 |
The protective effect of huperzine A against hepatic ischemia reperfusion injury in mice.
Topics: Alkaloids; Animals; Disease Models, Animal; Inflammation Mediators; Liver; Liver Function Tests; Male; Mice; Reperfusion Injury; Sesquiterpenes | 2014 |
The neurovascular protective effects of huperzine A on D-galactose-induced inflammatory damage in the rat hippocampus.
Topics: Aging; Alkaloids; Animals; Apoptosis; Blood-Brain Barrier; Cholinesterase Inhibitors; Cytokines; Encephalitis; Endothelial Cells; Galactose; Hippocampus; I-kappa B Proteins; Leukocytes; Male; Neuroglia; Neuroprotective Agents; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sesquiterpenes | 2014 |
Lumazine peptides penilumamides B-D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus.
Topics: Alkaloids; Animals; Anthozoa; Aspergillus; Bacillus cereus; Escherichia coli; Methionine; Microbial Sensitivity Tests; Molecular Structure; Nocardia; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Peptides, Cyclic; Pseudomonas; Pteridines; Salmonella enterica; Sesquiterpenes; Staphylococcus; Vibrio | 2014 |
Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Line; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Diterpenes, Kaurane; Enzyme Induction; Genes, Reporter; Humans; Plasmids; Pregnane X Receptor; Pyrazines; Real-Time Polymerase Chain Reaction; Receptors, Steroid; RNA, Messenger; Sesquiterpenes; Signal Transduction; Transfection | 2014 |
[Design, synthesis and evaluation of N-acyl-4-phenylthiazole-2-amines as acetylcholinesterase inhibitors].
Topics: Acetylcholinesterase; Alkaloids; Amines; Cholinesterase Inhibitors; Drug Design; Rivastigmine; Sesquiterpenes; Structure-Activity Relationship; Thiazoles | 2014 |
Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A.
Topics: Alkaloids; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cluster Analysis; Colletotrichum; DNA, Fungal; DNA, Ribosomal Spacer; Endophytes; Huperzia; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Sequence Analysis, DNA; Sesquiterpenes; Tandem Mass Spectrometry | 2014 |
Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
Topics: Alkaloids; Biological Products; Biotransformation; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Endophytes; Huperzia; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Sesquiterpenes | 2014 |
Construction of an immobilised acetylcholinesterase column and its application in screening insecticidal constituents from Magnolia officinalis.
Topics: Acetylcholinesterase; Alkaloids; Animals; Biphenyl Compounds; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Female; Hemiptera; Insecticides; Lignans; Magnolia; Plant Extracts; Sesquiterpenes | 2015 |
Anti-cholinesterase activity of lycopodium alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis.
Topics: Alkaloids; Cholinesterase Inhibitors; Huperzia; Inhibitory Concentration 50; Lycopodium; Plant Extracts; Sesquiterpenes | 2014 |
Huperzine A production by Paecilomyces tenuis YS-13, an endophytic fungus isolated from Huperzia serrata.
Topics: Alkaloids; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Endophytes; Fermentation; Huperzia; Mass Spectrometry; Molecular Structure; Paecilomyces; Sesquiterpenes | 2015 |
Physiological and neurobehavioral effects of cholinesterase inhibition in healthy adults.
Topics: Acetylcholinesterase; Adolescent; Adult; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Female; Galantamine; Humans; Indans; Male; Memory; Piperidines; Reaction Time; Sesquiterpenes; Young Adult | 2015 |
Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Drug Discovery; Hep G2 Cells; Humans; Models, Molecular; Nootropic Agents; Sesquiterpenes; Tacrine | 2015 |
De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A.
Topics: Alkaloids; Amine Oxidase (Copper-Containing); Colletotrichum; Gene Expression Profiling; Gene Ontology; Genes, Fungal; High-Throughput Nucleotide Sequencing; Microsatellite Repeats; Molecular Sequence Annotation; RNA, Messenger; Sequence Analysis, RNA; Sesquiterpenes | 2015 |
Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Mitochondria; Neurons; Peptide Fragments; Protein Aggregation, Pathological; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2015 |
Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognition Disorders; Huperzia; Japan; Memory Disorders; Mice; Plant Extracts; Scopolamine; Sesquiterpenes | 2015 |
Huperzine A protects neural stem cells against Aβ-induced apoptosis in a neural stem cells and microglia co-culture system.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytoprotection; Hippocampus; Inflammation Mediators; Microglia; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Paracrine Communication; Peptide Fragments; Rats, Sprague-Dawley; Sesquiterpenes; Time Factors | 2015 |
Cyclobutane Synthesis and Fragmentation. A Cascade Route to the Lycopodium Alkaloid (-)-Huperzine A.
Topics: Alkaloids; Bridged Bicyclo Compounds; Cyclization; Cyclobutanes; Cyclohexanones; Lycopodium; Pyridines; Sesquiterpenes; Stereoisomerism | 2015 |
Approach to cis-Phlegmarine Alkaloids via Stereodivergent Reduction: Total Synthesis of (+)-Serratezomine E and Putative Structure of (-)-Huperzine N.
Topics: Alkaloids; Catalysis; Hydrogenation; Lycopodium; Molecular Structure; Quinolines; Sesquiterpenes; Stereoisomerism | 2015 |
Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition.
Topics: Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Male; Neural Inhibition; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Sesquiterpenes | 2015 |
Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway.
Topics: Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Cell Line; Cell Survival; Glutamic Acid; Hippocampus; Mice; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, trkB; Sesquiterpenes; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Combined use of cyclofructans and an amino acid ester-based ionic liquid for the enantioseparation of huperzine A and coumarin derivatives in CE.
Topics: Alkaloids; Coumarins; Electrophoresis, Capillary; Fructans; Ionic Liquids; Reproducibility of Results; Sesquiterpenes; Stereoisomerism | 2015 |
Assessment of the neuroprotective effects of the acetylcholinesterase inhibitor huperzine A in an experimental spinal cord trauma model.
Topics: Alkaloids; Animals; Apoptosis; Behavior, Animal; Cholinesterase Inhibitors; Disease Models, Animal; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar; Sesquiterpenes; Spinal Cord Injuries | 2018 |
Avertoxins A-D, Prenyl Asteltoxin Derivatives from Aspergillus versicolor Y10, an Endophytic Fungus of Huperzia serrata.
Topics: Alkaloids; Aspergillus; Cholinesterase Inhibitors; HCT116 Cells; HeLa Cells; Humans; Huperzia; Inhibitory Concentration 50; Molecular Structure; Neoprene; Nuclear Magnetic Resonance, Biomolecular; Pyrones; Sesquiterpenes | 2015 |
Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice.
Topics: Acetylcholinesterase; Alkaloids; Ambenonium Chloride; Analgesics; Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Chronic Pain; Clonidine; Gyrus Cinguli; Hyperalgesia; Inflammation; Learning; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Neuralgia; Pain Threshold; Peroneal Nerve; Receptors, Muscarinic; Sesquiterpenes | 2015 |
Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives.
Topics: Alkaloids; Aminoquinolines; Cholinesterase Inhibitors; Drug Design; Heterocyclic Compounds, 4 or More Rings; Molecular Docking Simulation; Molecular Structure; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Sesquiterpenes; Tacrine | 2016 |
Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Animals; Anti-Inflammatory Agents; Apoptosis; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Encephalitis; Hippocampus; Lipopolysaccharides; Male; Rats; Rats, Wistar; Receptors, Muscarinic; Sepsis-Associated Encephalopathy; Sesquiterpenes; Spatial Learning; Spatial Memory | 2016 |
Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons.
Topics: Acetylcholinesterase; Adenosine Triphosphate; Alkaloids; Animals; Antioxidants; Cells, Cultured; Cerebral Cortex; Ferric Compounds; Iron; Iron Overload; Mitochondria; Neurons; Oxidative Stress; Quaternary Ammonium Compounds; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction | 2016 |
Effect of Huperzine A on Aβ-induced p65 of astrocyte in vitro.
Topics: Alkaloids; Amyloid beta-Peptides; Animals; Astrocytes; Mice; Peptide Fragments; Sesquiterpenes; Transcription Factor RelA | 2016 |
Chemical Transformation of an Intermediate in the Synthesis of Huperzine A, Leading to a Diverse Array of Molecules.
Topics: Alkaloids; Molecular Structure; Sesquiterpenes | 2016 |
Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A.
Topics: Aged; Alkaloids; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Stability; Female; Hepatocytes; Humans; Inactivation, Metabolic; Kidney; Male; Microsomes, Liver; Middle Aged; Sesquiterpenes | 2016 |
Time Course, Behavioral Safety, and Protective Efficacy of Centrally Active Reversible Acetylcholinesterase Inhibitors in Cynomolgus Macaques.
Topics: Alkaloids; Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Macaca fascicularis; Male; Pyridostigmine Bromide; Reaction Time; Seizures; Sesquiterpenes; Soman; Time Factors; Treatment Outcome | 2017 |
Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Anticonvulsants; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Disease Progression; Epilepsy; GABAergic Neurons; Hippocampus; Humans; Interleukin-1beta; Memory; Neurons; Neuroprotective Agents; Phosphorylation; Risk; Risk Factors; Seizures; Sesquiterpenes; Tumor Necrosis Factor-alpha | 2017 |
A novel assay to determine acetylcholinesterase activity: The application potential for screening of drugs against Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain Chemistry; Choline; Cholinesterase Inhibitors; Chromatography, Liquid; Drug Discovery; Hydrophobic and Hydrophilic Interactions; Mice; Sesquiterpenes; Tandem Mass Spectrometry | 2017 |
Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A.
Topics: Alkaloids; Computational Biology; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Ontology; High-Throughput Nucleotide Sequencing; Huperzia; Metabolic Networks and Pathways; Molecular Sequence Annotation; Phylogeny; Reproducibility of Results; Sesquiterpenes; Transcriptome | 2017 |
Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression.
Topics: Alkaloids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liquid; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Hippocampus; Male; Neurotransmitter Agents; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stroke | 2017 |
Expression and functional analysis of the lysine decarboxylase and copper amine oxidase genes from the endophytic fungus Colletotrichum gloeosporioides ES026.
Topics: Alkaloids; Amine Oxidase (Copper-Containing); Carboxy-Lyases; Chromatography, Liquid; Colletotrichum; Enzyme Activation; Escherichia coli; Gene Expression; Gene Order; Lysine; Plasmids; Recombinant Proteins; Sesquiterpenes | 2017 |
Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Brain; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Sesquiterpenes; Tissue Distribution | 2017 |
Effects of Huperzin-A on the Beta-amyloid accumulation in the brain and skeletal muscle cells of a rat model for Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Female; Gene Expression Regulation; MicroRNAs; Muscle, Skeletal; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Sesquiterpenes | 2017 |
Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury.
Topics: Alkaloids; Animals; Behavior, Animal; Brain Injuries, Traumatic; Cognition; Encephalitis; Learning; Memory; Mice; Motor Activity; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Sesquiterpenes | 2017 |
Muscarinic acetylcholine receptor but not nicotinic acetylcholine receptor plays a role in morphine-induced behavioral sensitization in rats.
Topics: Alkaloids; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Mecamylamine; Morphine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Sesquiterpenes | 2017 |
Alterations in the Timing of Huperzine A Cerebral Pharmacodynamics in the Acute Traumatic Brain Injury Setting.
Topics: Alkaloids; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Cholinesterase Inhibitors; Male; Neural Inhibition; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Transcranial Magnetic Stimulation | 2018 |
Muscarinic receptors in the nucleus accumbens shell play different roles in context-induced or morphine-challenged expression of behavioral sensitization in rats.
Topics: Alkaloids; Animals; Behavior, Animal; Male; Morphine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine; Sesquiterpenes | 2018 |
Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer's disease.
Topics: Administration, Intranasal; Alkaloids; Alzheimer Disease; Animals; Brain; Chitosan; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Lactoferrin; Mice; Nanoparticles; Neuroprotective Agents; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sesquiterpenes; Tissue Distribution | 2018 |
Binding free energy calculations to rationalize the interactions of huprines with acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Binding Sites; Cholinesterase Inhibitors; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Sesquiterpenes; Tacrine; Thermodynamics | 2018 |
A Study of a Supplement Containing Huperzine A and Curcumin in Dementia Patients and Individuals with Mild Cognitive Impairment.
Topics: Aged; Aged, 80 and over; Alkaloids; Biosimilar Pharmaceuticals; Cognition Disorders; Curcumin; Dementia, Vascular; Dietary Supplements; Female; Humans; Male; Neuropsychological Tests; Psychiatric Status Rating Scales; Retrospective Studies; Sesquiterpenes; Treatment Outcome | 2018 |
Identification of Lycopodium Alkaloids Produced by an Ultraviolet-Irradiated Strain of Paraboeremia, an Endophytic Fungus from Lycopodium serratum var. longipetiolatum.
Topics: Alkaloids; Fungi; Lycopodium; Quinolizines; Sesquiterpenes; Ultraviolet Rays | 2018 |
Kinetics of Huperzine A Dissociation from Acetylcholinesterase via Multiple Unbinding Pathways.
Topics: Acetylcholinesterase; Alkaloids; Animals; Binding Sites; Catalytic Domain; Cholinesterase Inhibitors; Kinetics; Likelihood Functions; Molecular Dynamics Simulation; Protein Structure, Tertiary; Sesquiterpenes; Thermodynamics; Torpedo | 2018 |
[Molecular cloning, expression and characterization of lysine decarboxylase gene of endophytic fungus Shiraia sp. Slf14 from Huperzia serrata].
Topics: Alkaloids; Ascomycota; Biocatalysis; Carboxy-Lyases; Cloning, Molecular; Endophytes; Fungal Proteins; Huperzia; Lysine; Molecular Weight; Sesquiterpenes | 2016 |
[Detection of Huperzine A and Huperzine B in fermentation broth of endophytic fungus Colletotrichum gloesporioides from Huperzia serrate by HPLC].
Topics: Alkaloids; Chromatography, High Pressure Liquid; Colletotrichum; Fermentation; Huperzia; Industrial Microbiology; Reproducibility of Results; Sesquiterpenes | 2018 |
[Cholinergic anti-inflammatory pathway involves in the neuroprotective effect of huperzine A on sepsis-associated encephalopathy].
Topics: Acetylcholine; Alkaloids; Animals; Anti-Inflammatory Agents; Apoptosis; Choline O-Acetyltransferase; Cholinergic Agents; Cytokines; Interleukin-1beta; Lipopolysaccharides; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Sepsis; Sepsis-Associated Encephalopathy; Sesquiterpenes; Tumor Necrosis Factor-alpha | 2016 |
Protective properties of Huperzine A through activation Nrf2/ARE-mediated transcriptional response in X-rays radiation-induced NIH3T3 cells.
Topics: Alkaloids; Animals; Antioxidant Response Elements; Apoptosis; Catalase; Cell Cycle; Chromones; Flavonoids; Gene Expression Regulation; Glutathione Peroxidase; Imidazoles; Kelch-Like ECH-Associated Protein 1; Lipid Peroxides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-E2-Related Factor 2; NIH 3T3 Cells; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Radiation-Protective Agents; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Superoxide Dismutase; X-Rays | 2018 |
Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Databases, Chemical; Donepezil; Drug Discovery; Galantamine; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Quantitative Structure-Activity Relationship; Sesquiterpenes | 2019 |
Production and enhancement of the acetylcholinesterase inhibitor, huperzine A, from an endophytic Alternaria brassicae AGF041.
Topics: Alkaloids; Alternaria; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Fermentation; Huperzia; Mycelium; Prospective Studies; Sesquiterpenes | 2019 |
The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Sesquiterpenes | 2020 |
Decahydroquinoline Ring
Topics: Alkaloids; Lycopodium; Magnetic Resonance Spectroscopy; Molecular Structure; Quinolines; Sesquiterpenes; Stereoisomerism | 2019 |
ABAD/17β-HSD10 reduction contributes to the protective mechanism of huperzine a on the cerebral mitochondrial function in APP/PS1 mice.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Survival; Cytochromes c; Disease Models, Animal; Male; Mice, Transgenic; Mitochondria; Neuroprotective Agents; Reactive Oxygen Species; Sesquiterpenes; Tacrine | 2019 |
Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice.
Topics: Acetylcholine; Alkaloids; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Cognitive Dysfunction; Hippocampus; Male; Memory; Memory Disorders; Mice, Inbred C57BL; Neurotransmitter Agents; Oxidative Stress; Peganum; Quinazolines; Scopolamine; Sesquiterpenes | 2019 |
Biotransformation of Huperzine A by Irpex lacteus-A fungal endophyte of Huperzia serrata.
Topics: Alkaloids; Biotransformation; Cell Line, Tumor; China; Endophytes; Humans; Huperzia; Neuroprotective Agents; Phytochemicals; Plants, Medicinal; Polyporales; Sesquiterpenes | 2019 |
A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study.
Topics: Administration, Intranasal; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Drug Compounding; Drug Delivery Systems; Emulsions; Gels; Hydrogen-Ion Concentration; Male; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Temperature | 2019 |
Neuroprotective Effect of Huperzine A on d-Galactose-Induced Hearing Dysfunction.
Topics: Alkaloids; Animals; Cellular Senescence; Cochlea; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Galactose; Hearing Loss; Intermediate Filaments; Neurons; Neuroprotective Agents; Rats; Sesquiterpenes | 2021 |
Frequency domain modeling of quasielastic neutron scattering from hydrated protein powders: Application to free and inhibited human acetylcholinesterase.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Humans; Neutron Diffraction; Protein Domains; Sesquiterpenes | 2019 |
Identification of a Huperzine A-producing endophytic fungus from Phlegmariurus taxifolius.
Topics: Alkaloids; Cholinesterase Inhibitors; DNA, Fungal; Endophytes; Fusarium; Lycopodiaceae; Sesquiterpenes | 2020 |
Isolation of endophytic fungi and screening of Huperzine A-producing fungus from Huperzia serrata in Vietnam.
Topics: Acetylcholinesterase; Alkaloids; Ascomycota; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA, Fungal; DNA, Ribosomal Spacer; Endophytes; Huperzia; Mucor; Mycological Typing Techniques; Phylogeny; Sesquiterpenes; Species Specificity; Vietnam | 2019 |
Dental resin as controlled release layer for the development of an innovative long-acting intra-oral delivery system.
Topics: Administration, Oral; Alkaloids; Animals; Cholinesterase Inhibitors; Delayed-Action Preparations; Drug Liberation; Mouth Mucosa; Neuroprotective Agents; Rabbits; Resins, Synthetic; Sesquiterpenes; Tablets | 2020 |
The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route.
Topics: Administration, Intranasal; Alkaloids; Alzheimer Disease; Animals; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Drug Liberation; Emulsions; Humans; Lactoferrin; Male; Nanoparticles; Nasal Mucosa; Particle Size; Phase Transition; Rats, Wistar; Sesquiterpenes; Solubility; Static Electricity; Tissue Distribution | 2019 |
Differential blockade by huperzine A and donepezil of sympathetic nicotinic acetylcholine receptor-mediated nitrergic neurogenic dilations in porcine basilar arteries.
Topics: Alkaloids; Alzheimer Disease; Animals; Basilar Artery; Brain Stem; Calcium; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Dose-Response Relationship, Drug; Humans; Models, Animal; Nicotine; Nitrergic Neurons; Oocytes; Patch-Clamp Techniques; Rats; Receptors, Nicotinic; Sesquiterpenes; Swine; Synaptic Transmission; Vasodilation; Xenopus laevis | 2020 |
Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection.
Topics: Alkaloids; Alzheimer Disease; Animals; Antioxidants; Cholinesterase Inhibitors; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Sesquiterpenes; Xanthophylls | 2020 |
Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Amines; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Molecular Docking Simulation; Neuroprotective Agents; Rivastigmine; Sesquiterpenes; Structure-Activity Relationship; Thiazoles | 2020 |
Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia.
Topics: Alkaloids; Anesthesia; Anesthetics, Inhalation; Animals; Enzyme-Linked Immunosorbent Assay; Hippocampus; Humans; Interleukin-1beta; Interleukin-6; Isoflurane; Male; Maze Learning; Nerve Growth Factors; Neuroprotective Agents; Postoperative Cognitive Complications; Random Allocation; Rats, Sprague-Dawley; Reproducibility of Results; Sesquiterpenes; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2020 |
A novel huperzine A-producing endophytic fungus Fusarium sp. Rsp5.2 isolated from Huperzia serrate.
Topics: Alkaloids; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Fusarium; Huperzia; Mycelium; Sesquiterpenes; Vietnam | 2020 |
Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.
Topics: Alkaloids; Animals; Apoptosis; Behavior, Animal; Caspase 3; Cation Transport Proteins; Cognition Disorders; Disease Models, Animal; Ferritins; Hippocampus; Hypoxia; Iron Overload; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neuroprotective Agents; Oxidative Stress; Oxygen; Reactive Oxygen Species; Receptors, Transferrin; Sesquiterpenes | 2020 |
Huperzine A inhibits heroin-seeking behaviors induced by cue or heroin priming in rats.
Topics: Alkaloids; Animals; Behavior, Animal; Cholinesterase Inhibitors; Cues; Drug-Seeking Behavior; Heroin; Heroin Dependence; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reward; Sesquiterpenes | 2020 |
Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease.
Topics: Administration, Cutaneous; Alkaloids; Animals; Area Under Curve; Biocompatible Materials; Cholinesterase Inhibitors; Drug Delivery Systems; Drug Liberation; Half-Life; Male; Microinjections; Needles; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Skin | 2020 |
Five novel and highly efficient endophytic fungi isolated from Huperzia serrata expressing huperzine A for the treatment of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Endophytes; Fusarium; Humans; Huperzia; Hypocreales; Mucor; Sesquiterpenes | 2020 |
Huperzine-A administration recovers rat ovary function after sympathetic stress.
Topics: Acetylcholine; Alkaloids; Animals; Cholinesterase Inhibitors; Cold Temperature; Disease Models, Animal; Estradiol; Female; Norepinephrine; Ovary; Polycystic Ovary Syndrome; Progesterone; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stress, Physiological; Sympathetic Nervous System; Testosterone | 2021 |
Response surface methodology-mediated improvement of the irradiated endophytic fungal strain, Alternaria brassicae AGF041 for Huperzine A-hyperproduction.
Topics: Alkaloids; Alternaria; Bioreactors; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Endophytes; Fermentation; Gamma Rays; Huperzia; Neuroprotective Agents; Sesquiterpenes; Ultraviolet Rays | 2021 |
The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix.
Topics: Acetylcholinesterase; Alkaloids; Benzylisoquinolines; Berberine; Binding Sites; Butyrylcholinesterase; China; Cholinesterase Inhibitors; Donepezil; Drug Combinations; Drug Synergism; GPI-Linked Proteins; Humans; Molecular Docking Simulation; Neuroprotective Agents; Plant Extracts; Plants, Medicinal; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Sesquiterpenes; Solvents; Stephania tetrandra | 2020 |
Metric-Based Analysis of Convergence in Complex Molecule Synthesis.
Topics: Alkaloids; Anti-Infective Agents; Diterpenes; Fluorenes; Molecular Conformation; Polyketides; Quinones; Sesquiterpenes; Stereoisomerism | 2021 |
Endophytic Fungal Community of
Topics: Alkaloids; Biodiversity; Endophytes; Fungi; Huperzia; Sesquiterpenes | 2021 |
Effect of continuous and multi-phasic current profiles on the iontophoretic transport of pramipexole, rasagiline and huperzine A: Depicting temporal variation and biodistribution in the skin.
Topics: Administration, Cutaneous; Alkaloids; Indans; Iontophoresis; Pramipexole; Sesquiterpenes; Skin; Tissue Distribution | 2021 |
Simultaneous separation and determination of three huperzine alkaloids in Huperzia serrata and its preparations by cyclodextrin-modified mixed micellar electrokinetic capillary chromatography.
Topics: Alkaloids; Chromatography, Micellar Electrokinetic Capillary; Cyclodextrins; Electrophoresis, Capillary; Huperzia; Hydrogen-Ion Concentration; Limit of Detection; Sesquiterpenes; Signal-To-Noise Ratio; Sodium Cholate; Sodium Dodecyl Sulfate | 2021 |
A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis.
Topics: Alkaloids; Biosynthetic Pathways; Lycopodium; Metabolomics; Mixed Function Oxygenases; Oxidation-Reduction; Piperidines; Regulon; Sesquiterpenes; Transcriptome | 2021 |
Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil.
Topics: Acetylcholinesterase; Alkaloids; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Fractals; Galantamine; Sesquiterpenes | 2021 |
Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of
Topics: Alkaloids; Alzheimer Disease; Blood-Brain Barrier; Catalysis; Cell Line, Tumor; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Palladium; Sesquiterpenes; Structure-Activity Relationship | 2021 |
New and potent production platform of the acetylcholinesterase inhibitor huperzine A by gamma-irradiated Alternaria brassicae under solid-state fermentation.
Topics: Acetylcholinesterase; Alkaloids; Alternaria; Cholinesterase Inhibitors; Fermentation; Gamma Rays; Sesquiterpenes | 2021 |
Mechanistic Insight into Binding of Huperzine A with Human Serum Albumin: Computational and Spectroscopic Approaches.
Topics: Alkaloids; Humans; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuroprotective Agents; Principal Component Analysis; Protein Binding; Serum Albumin, Human; Sesquiterpenes; Spectrometry, Fluorescence | 2022 |
Diversity of endophytic fungal community in Huperzia serrata from different ecological areas and their correlation with Hup A content.
Topics: Alkaloids; Ascomycota; Basidiomycota; Biodiversity; Endophytes; Fungi; Huperzia; Mycobiome; Sesquiterpenes | 2022 |
Investigation of the "Nose-to-Brain" Pathways in Intranasal HupA Nanoemulsions and Evaluation of Their in vivo Pharmacokinetics and Brain-Targeting Ability.
Topics: Administration, Intranasal; Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Brain; Drug Delivery Systems; Nasal Mucosa; Neoplasm Proteins; Rats; Sesquiterpenes | 2022 |