huperzine a has been researched along with donepezil in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 5 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X | 1 |
| Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS | 1 |
| Cheng, DH; Ren, H; Tang, XC | 1 |
| Cheng, DH; Tang, XC | 1 |
| Tang, XC; Wang, T | 1 |
| Hu, GY; Lin, JH; Tang, XC | 2 |
| Tang, XC; Wang, H | 1 |
| Chen, K; Ji, R; Jiang, H; Zeng, F; Zhai, Y; Zhang, H | 1 |
| Kaur, J; Zhang, MQ | 1 |
| Koellner, G; Kryger, G; Millard, CB; Silman, I; Steiner, T; Sussman, JL | 1 |
| Fu, Y; Tang, XC; Zhou, J | 1 |
| Tang, XC; Zhao, Q | 1 |
| Bai, DL; Jin, GY; Xia, Y | 1 |
| Liang, YQ; Tang, XC | 2 |
| Darvesh, S; Duysen, EG; Li, B; Lockridge, O | 1 |
| Tang, XC; Wang, J; Zhang, HY | 1 |
| Adler, M; Akkerman, M; Albuquerque, EX; Aracava, Y; Pereira, EF | 1 |
| Aisen, PS; Cummings, J; Schneider, LS | 1 |
| Chandrashankra, O; Hu, Y; Ip, FC; Ip, NY; Zhang, J | 1 |
| Aaron, CL; Gordon, RK; Moon, JE; Morasch, KC | 1 |
| Lee, KW; Park, C; Rampogu, S; Son, M; Zeb, A | 1 |
| Chen, MF; Chen, PY; Lee, TJF; Shih, CC | 1 |
| Dong, TTX; Duan, R; Guo, SC; Kong, XP; Leung, KW; Liu, EYL; Ren, HQ; Tsim, KWK | 1 |
| Grigorev, VY; Grigoreva, LD; Rasdolsky, AN; Tinkov, OV | 1 |
| Fu, Y; Li, J; Li, X; Lian, F; Lu, Z; Mao, F; Ni, W; Wang, H; Zhang, H; Zhang, N; Zheng, X; Zhu, J | 1 |
| Dong, SN; Gong, Q; Li, J; Li, XK; Liu, WW; Mao, F; Tang, Y; Wang, H; Wang, TD; Xu, YX; Zhang, HY; Zhu, J | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Bai, F; Fu, Y; Gong, Q; Hong, Y; Jiang, H; Li, J; Liu, H; Liu, Q; Peng, T; Wang, W; Xu, HE; Xu, S; Xu, Y; Yin, W; Zhang, D; Zhang, H; Zhou, Y | 1 |
5 review(s) available for huperzine a and donepezil
| Article | Year |
|---|---|
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine | 2000 |
[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Topics: Alkaloids; Cholinesterase Inhibitors; Donepezil; Indans; Molecular Conformation; Molecular Structure; Piperidines; Sesquiterpenes; Tacrine | 2002 |
Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
Topics: Acetylcholine; Alkaloids; Animals; Anti-Inflammatory Agents; Cholinergic Agents; Cholinesterase Inhibitors; Dementia, Vascular; Disease Models, Animal; Donepezil; Galantamine; Humans; Indans; Inflammation; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, Cholinergic; Rivastigmine; Sesquiterpenes; Signal Transduction | 2009 |
Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.
Topics: Alkaloids; Alzheimer Disease; Amino Acids; Animals; Cholinesterase Inhibitors; Dietary Supplements; Disease Progression; Docosahexaenoic Acids; Donepezil; Drug Approval; Galantamine; Ginkgo biloba; Half-Life; History, 20th Century; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Psychotropic Drugs; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Sesquiterpenes; Vitamin B Complex; Vitamin E | 2012 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
25 other study(ies) available for huperzine a and donepezil
| Article | Year |
|---|---|
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.
Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship | 2002 |
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo | 2006 |
Huperzine A, a novel promising acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1996 |
Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities.
Topics: Alkaloids; Animals; Aziridines; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Injections, Intraventricular; Male; Maze Learning; Memory; Memory, Short-Term; Neuromuscular Blocking Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1998 |
Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; In Vitro Techniques; Indans; Male; Mice; Neuromuscular Junction; Piperidines; Sesquiterpenes; Synaptic Transmission; Taurine | 1996 |
Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.
Topics: Action Potentials; Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; Indans; Male; Membrane Potentials; Mice; Muscle Fibers, Skeletal; Neuromuscular Junction; Phrenic Nerve; Piperidines; Sesquiterpenes; Tacrine | 1997 |
Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Hippocampus; In Vitro Techniques; Indans; Neuroprotective Agents; Nootropic Agents; Piperidines; Rats; Sesquiterpenes | 1999 |
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
Topics: Acetylcholinesterase; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Donepezil; Edrophonium; Hydrogen Bonding; Indans; Ligands; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Structure, Secondary; Reproducibility of Results; Sesquiterpenes; Static Electricity; Torpedo; Water | 2000 |
Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
Topics: Alkaloids; Alzheimer Disease; Animals; Cell Size; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Glucose; Hypoxia-Ischemia, Brain; Indans; Lipid Peroxidation; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Rats; Sesquiterpenes; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2001 |
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine | 2002 |
Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain Chemistry; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fasciculation; Indans; Male; Neurons; Phenylcarbamates; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Up-Regulation | 2004 |
Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.
Topics: Acetylcholine; Administration, Oral; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Indans; Male; Neuroprotective Agents; Norepinephrine; Phenylcarbamates; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Rivastigmine; Serotonin; Sesquiterpenes | 2006 |
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; Chlorpyrifos; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Mice; Mice, Knockout; Neurotoxicity Syndromes; Piperidines; Sesquiterpenes; Synaptic Transmission | 2007 |
Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Chemical Warfare Agents; Donepezil; Dose-Response Relationship, Drug; Galantamine; Guinea Pigs; Indans; Lethal Dose 50; Male; Phenylcarbamates; Piperidines; Poisoning; Rivastigmine; Sesquiterpenes; Soman; Time Factors; Toxicity Tests, Acute | 2009 |
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Drug Design; Indans; Molecular Structure; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Structure-Activity Relationship | 2013 |
Physiological and neurobehavioral effects of cholinesterase inhibition in healthy adults.
Topics: Acetylcholinesterase; Adolescent; Adult; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Female; Galantamine; Humans; Indans; Male; Memory; Piperidines; Reaction Time; Sesquiterpenes; Young Adult | 2015 |
Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Databases, Chemical; Donepezil; Drug Discovery; Galantamine; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Quantitative Structure-Activity Relationship; Sesquiterpenes | 2019 |
Differential blockade by huperzine A and donepezil of sympathetic nicotinic acetylcholine receptor-mediated nitrergic neurogenic dilations in porcine basilar arteries.
Topics: Alkaloids; Alzheimer Disease; Animals; Basilar Artery; Brain Stem; Calcium; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Dose-Response Relationship, Drug; Humans; Models, Animal; Nicotine; Nitrergic Neurons; Oocytes; Patch-Clamp Techniques; Rats; Receptors, Nicotinic; Sesquiterpenes; Swine; Synaptic Transmission; Vasodilation; Xenopus laevis | 2020 |
The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix.
Topics: Acetylcholinesterase; Alkaloids; Benzylisoquinolines; Berberine; Binding Sites; Butyrylcholinesterase; China; Cholinesterase Inhibitors; Donepezil; Drug Combinations; Drug Synergism; GPI-Linked Proteins; Humans; Molecular Docking Simulation; Neuroprotective Agents; Plant Extracts; Plants, Medicinal; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Sesquiterpenes; Solvents; Stephania tetrandra | 2020 |
Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil.
Topics: Acetylcholinesterase; Alkaloids; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Fractals; Galantamine; Sesquiterpenes | 2021 |
Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line; Cholinesterase Inhibitors; Cognition; Drug Design; Humans; Mice, Inbred ICR; Neuroprotective Agents; Protein Aggregates; Reactive Oxygen Species; Thiourea | 2016 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imidazoles; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyrimidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea | 2018 |
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Dogs; Drug Design; Female; Humans; Indans; Kinetics; Male; Mice, Inbred ICR; Molecular Structure; Nootropic Agents; Piperidines; Protein Binding; Rats, Sprague-Dawley; Scopolamine; Structure-Activity Relationship | 2021 |