hu-243 and nabilone

hu-243 has been researched along with nabilone* in 1 studies

Other Studies

1 other study(ies) available for hu-243 and nabilone

Article	Year
Synthesis and pharmacological properties of 11-hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol: a high-affinity cannabinoid agonist. Journal of medicinal chemistry, 1994, Aug-05, Volume: 37, Issue:16 11-Hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol (1) was synthesized from the known cannabimimetic analog (+/-)-nabilone. Racemic 1 was resolved by HPLC on a semipreparative CHIRALCEL OD column (Daicel, Inc.), and pharmacological activities of the individual enantiomers were evaluated in the mouse model. The (-)-enantiomer was found to be much more potent than the (+)-enantiomer in all the four measures with the potency ratios in the production of catalepsy (RI), hypoactivity (SA), hypothermia (RT), and antinociception (TF) being 93, 143, 186, and 322, respectively. The racemic 11 alpha-OH diastereomer (2), a reaction side product, was also evaluated in the mouse model. Only small differences in the pharmacological activity of racemic 1 and 2 were found in the above four measures. Topics: Analgesia; Animals; Body Temperature; Cannabinoids; Cannabinol; Catalepsy; Chromatography, High Pressure Liquid; Dronabinol; Mice; Motor Activity; Stereoisomerism; Structure-Activity Relationship	1994

Article

Year

Synthesis and pharmacological properties of 11-hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol: a high-affinity cannabinoid agonist.

Journal of medicinal chemistry, 1994, Aug-05, Volume: 37, Issue:16

11-Hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol (1) was synthesized from the known cannabimimetic analog (+/-)-nabilone. Racemic 1 was resolved by HPLC on a semipreparative CHIRALCEL OD column (Daicel, Inc.), and pharmacological activities of the individual enantiomers were evaluated in the mouse model. The (-)-enantiomer was found to be much more potent than the (+)-enantiomer in all the four measures with the potency ratios in the production of catalepsy (RI), hypoactivity (SA), hypothermia (RT), and antinociception (TF) being 93, 143, 186, and 322, respectively. The racemic 11 alpha-OH diastereomer (2), a reaction side product, was also evaluated in the mouse model. Only small differences in the pharmacological activity of racemic 1 and 2 were found in the above four measures.

Topics: Analgesia; Animals; Body Temperature; Cannabinoids; Cannabinol; Catalepsy; Chromatography, High Pressure Liquid; Dronabinol; Mice; Motor Activity; Stereoisomerism; Structure-Activity Relationship

1994