hr22c16 and tryptoline

hr22c16 has been researched along with tryptoline* in 1 studies

Other Studies

1 other study(ies) available for hr22c16 and tryptoline

Article	Year
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5. Bioorganic & medicinal chemistry, 2005, Nov-15, Volume: 13, Issue:22 The mitotic kinesin Eg5 (or KSP) is a crucial player in the development and function of the mitotic spindle. Inhibition of this protein leads to cell cycle arrest and apoptosis without interfering with other microtubule-dependent processes. Therefore, it is a potential target in cancer therapy. Here, we report the synthesis and biological evaluation of a small library of molecules based on the structure of the known Eg5 inhibitor HR22C16. One of these derivatives (compound trans-24) proved to be a potent and specific Eg5 inhibitor. Topics: Animals; Carbolines; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Indoles; Inhibitory Concentration 50; Kinesins; Mitosis; Molecular Structure; Neurotoxins; Phenols; Xenopus Proteins	2005

Article

Year

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Bioorganic & medicinal chemistry, 2005, Nov-15, Volume: 13, Issue:22

The mitotic kinesin Eg5 (or KSP) is a crucial player in the development and function of the mitotic spindle. Inhibition of this protein leads to cell cycle arrest and apoptosis without interfering with other microtubule-dependent processes. Therefore, it is a potential target in cancer therapy. Here, we report the synthesis and biological evaluation of a small library of molecules based on the structure of the known Eg5 inhibitor HR22C16. One of these derivatives (compound trans-24) proved to be a potent and specific Eg5 inhibitor.

Topics: Animals; Carbolines; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Indoles; Inhibitory Concentration 50; Kinesins; Mitosis; Molecular Structure; Neurotoxins; Phenols; Xenopus Proteins

2005