hr22c16 and monastrol

hr22c16 has been researched along with monastrol* in 1 studies

Other Studies

1 other study(ies) available for hr22c16 and monastrol

Article	Year
Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly. Journal of molecular modeling, 2007, Volume: 13, Issue:9 Fifteen KSP inhibitors were docked into the receptor and the binding mode was analyzed for the first time. It was considered that in addition to the main binding pocket all the inhibitors merged in, there exists a cooperative minor binding pocket, which could be explored for significantly increased binding affinity. In addition, a good linear relationship between the biological activities and the lowest binding free energies has also been found. This may help in predicting the binding affinity of newly designed KSP inhibitors. Topics: Amino Acid Sequence; Amino Acids; Cysteine; Diterpenes; Hydrogen Bonding; Indoles; Kinesins; Models, Molecular; Phenols; Protein Binding; Pyrimidines; Spindle Apparatus; Thiones	2007

Article

Year

Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly.

Journal of molecular modeling, 2007, Volume: 13, Issue:9

Fifteen KSP inhibitors were docked into the receptor and the binding mode was analyzed for the first time. It was considered that in addition to the main binding pocket all the inhibitors merged in, there exists a cooperative minor binding pocket, which could be explored for significantly increased binding affinity. In addition, a good linear relationship between the biological activities and the lowest binding free energies has also been found. This may help in predicting the binding affinity of newly designed KSP inhibitors.

Topics: Amino Acid Sequence; Amino Acids; Cysteine; Diterpenes; Hydrogen Bonding; Indoles; Kinesins; Models, Molecular; Phenols; Protein Binding; Pyrimidines; Spindle Apparatus; Thiones

2007