horminone has been researched along with tingenone* in 2 studies
2 other study(ies) available for horminone and tingenone
| Article | Year |
|---|---|
Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi.
Tingenone and horminone, two natural quinonoid substances, inhibited the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth. Tingenone inhibited total uptake and incorporation of [3H]thymidine, [3H]uridine, L-[3H]leucine into parasite macromolecules. Other quinonoids assayed were either less effective (abruquinone A) or even quite inactive (visminone B and ferruginin B). Investigation of several mechanisms for the cytotoxic action of tingenone pointed to the interaction with DNA as the most likely factor involved. Tingenone also inhibited the growth of Crithidia fasciculata, but the drug was significantly less active on this organism than on T. cruzi. Topics: Abietanes; Animals; Biological Transport; Crithidia; Diterpenes; Nucleic Acids; Protein Biosynthesis; Triterpenes; Trypanocidal Agents; Trypanosoma cruzi | 1985 |
[Inhibition of growth and macromolecular biosynthesis in Trypanosoma cruzi by natural products. Effects of miconidine and tingenone].
Topics: Abietanes; Animals; Chemical Phenomena; Chemistry; Diterpenes; Hydroquinones; Plant Extracts; Triterpenes; Trypanosoma cruzi | 1984 |