horminone and taxodione

horminone has been researched along with taxodione* in 1 studies

Other Studies

1 other study(ies) available for horminone and taxodione

Article	Year
Effects of plant diterpenes on the neuronal GABAA receptor-operated chloride current. Neuroreport, 1994, Dec-20, Volume: 5, Issue:18 The effects of plant diterpenes, horminone (HMN) and taxodione (TXN), on the GABAA receptor-operated Cl-current (IGABA) were investigated in voltage-clamped and internally perfused neurones dissociated from frog dorsal root ganglia. Both diterpenes depressed IGABA in a concentration-dependent manner similar to that of picrotoxin. Concentrations required to elicit 50% depression of the IGABA were 10(-6) M for picrotoxin, 10(-5) M for HMN and 10(-4) M for TXN. Blocking and restoration kinetics of the IGABA with HMN were also similar to those of picrotoxin. Time constants for both the blockade and restoration of the IGABA with TXN were more than five times greater than those with HMN. Topics: Abietanes; Animals; Chlorides; Diterpenes; Electric Conductivity; gamma-Aminobutyric Acid; Ganglia, Spinal; Kinetics; Neurons, Afferent; Osmolar Concentration; Picrotoxin; Plant Extracts; Rana catesbeiana; Receptors, GABA	1994

Article

Year

Effects of plant diterpenes on the neuronal GABAA receptor-operated chloride current.

Neuroreport, 1994, Dec-20, Volume: 5, Issue:18

The effects of plant diterpenes, horminone (HMN) and taxodione (TXN), on the GABAA receptor-operated Cl-current (IGABA) were investigated in voltage-clamped and internally perfused neurones dissociated from frog dorsal root ganglia. Both diterpenes depressed IGABA in a concentration-dependent manner similar to that of picrotoxin. Concentrations required to elicit 50% depression of the IGABA were 10(-6) M for picrotoxin, 10(-5) M for HMN and 10(-4) M for TXN. Blocking and restoration kinetics of the IGABA with HMN were also similar to those of picrotoxin. Time constants for both the blockade and restoration of the IGABA with TXN were more than five times greater than those with HMN.

Topics: Abietanes; Animals; Chlorides; Diterpenes; Electric Conductivity; gamma-Aminobutyric Acid; Ganglia, Spinal; Kinetics; Neurons, Afferent; Osmolar Concentration; Picrotoxin; Plant Extracts; Rana catesbeiana; Receptors, GABA

1994