horminone and tanshinone

horminone has been researched along with tanshinone* in 1 studies

Other Studies

1 other study(ies) available for horminone and tanshinone

ArticleYear
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
    Bioorganic & medicinal chemistry, 2011, Aug-15, Volume: 19, Issue:16

    Phytochemical investigations of the n-hexane extract from the roots of Peltodon longipes (Lamiaceae) resulted in the isolation of 12 known abietane diterpenes (1-12). Structures were established on the basis of one and two dimensional nuclear magnetic resonance spectroscopic data ((1)H and (13)C, COSY, HSQC and HMBC), electron ionization mass spectrometric analysis (EIMS) as well as comparison with data from literature. These compounds, as well as eight known diterpenes (13-19) from Salvia miltiorrhiza, and two from Salvia sahendica (20 and 21) were evaluated for their cytotoxic effects in human pancreatic (MIAPaCa-2) and melanoma (MV-3) tumor cell lines using the MTT assay. Tanshinone IIa (13), 7α-acetoxyroyleanone (1), 1,2-dihydrotanshinone (16) and cryptotanshinone (14) had the highest cytotoxic effects in MIAPaCa-2, displaying IC(50) of 1.9, 4.7, 5.6, and 5.8 μM, respectively. Structure-activity relationships of abietane diterpenoid quinones are discussed.

    Topics: Abietanes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Humans; Lamiaceae; Phytotherapy; Plant Extracts; Plant Roots; Salvia; Structure-Activity Relationship

2011