homoharringtonine and drupacine

homoharringtonine has been researched along with drupacine* in 2 studies

Other Studies

2 other study(ies) available for homoharringtonine and drupacine

Article	Year
Convergency and divergency as strategic elements in total synthesis: the total synthesis of (-)-drupacine and the formal total synthesis of (+/-)-cephalotaxine, (-)-cephalotaxine, and (+)-cephalotaxine. The Journal of organic chemistry, 2007, Sep-14, Volume: 72, Issue:19 A concise route toward the syntheses of (-)-drupacine and (+)- and (-)-cephalotaxine has been developed. The syntheses rely on Pd(II)-catalyzed aerobic oxidative heterocyclization chemistry, which was employed to rapidly construct an important spirocyclic amine intermediate. A dynamic beta-elimination/conjugate addition process was strategically applied to complete the first asymmetric total synthesis of (-)-drupacine. Topics: Catalysis; Cyclization; Harringtonines; Homoharringtonine; Palladium; Stereoisomerism	2007
[Synthesis and antitumor activity of the derivatives of cephalotaxine and drupacine]. Yao xue xue bao = Acta pharmaceutica Sinica, 2003, Volume: 38, Issue:12 To make full use of cephalotaxus plant resources and search for antitumor agents with higher activities and lower side effects.. The C3 hydroxy groups of the cephlotaxine and drupacine were acylated by taxol side chain and its isomers to give a series of derivatives of cephlotaxine and drupacine.. Six novel alkaloid esters were designed and synthesized. The pharmacological screening results showed that VIIIa, VIIIb, IXa and IXc exhibited significant activities on KB, HCT and Bel in vitro.. Novel alkaloid esters are worthy to be intensively studied. Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Colonic Neoplasms; Harringtonines; Homoharringtonine; Humans; KB Cells; Liver Neoplasms; Tumor Cells, Cultured	2003

Article

Year

Convergency and divergency as strategic elements in total synthesis: the total synthesis of (-)-drupacine and the formal total synthesis of (+/-)-cephalotaxine, (-)-cephalotaxine, and (+)-cephalotaxine.

The Journal of organic chemistry, 2007, Sep-14, Volume: 72, Issue:19

A concise route toward the syntheses of (-)-drupacine and (+)- and (-)-cephalotaxine has been developed. The syntheses rely on Pd(II)-catalyzed aerobic oxidative heterocyclization chemistry, which was employed to rapidly construct an important spirocyclic amine intermediate. A dynamic beta-elimination/conjugate addition process was strategically applied to complete the first asymmetric total synthesis of (-)-drupacine.

Topics: Catalysis; Cyclization; Harringtonines; Homoharringtonine; Palladium; Stereoisomerism

2007

[Synthesis and antitumor activity of the derivatives of cephalotaxine and drupacine].

Yao xue xue bao = Acta pharmaceutica Sinica, 2003, Volume: 38, Issue:12

To make full use of cephalotaxus plant resources and search for antitumor agents with higher activities and lower side effects.. The C3 hydroxy groups of the cephlotaxine and drupacine were acylated by taxol side chain and its isomers to give a series of derivatives of cephlotaxine and drupacine.. Six novel alkaloid esters were designed and synthesized. The pharmacological screening results showed that VIIIa, VIIIb, IXa and IXc exhibited significant activities on KB, HCT and Bel in vitro.. Novel alkaloid esters are worthy to be intensively studied.

Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Colonic Neoplasms; Harringtonines; Homoharringtonine; Humans; KB Cells; Liver Neoplasms; Tumor Cells, Cultured

2003