homogentisic acid and tyrosine

homogentisic acid has been researched along with tyrosine in 83 studies

Research

Studies (83)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (50.60)	18.7374
1990's	7 (8.43)	18.2507
2000's	10 (12.05)	29.6817
2010's	13 (15.66)	24.3611
2020's	11 (13.25)	2.80

Authors

Authors	Studies
Katayama, H; Muramatsu, K; Yamamoto, Y	1
Coufalik, A; Monder, C	1
Muramatsu, K; Nakamura, K; Takei, M	1
Berezov, TT; Kurbanov, Kh	1
Lähdesmäki, P; Oja, SS; Vanhatalo, A	1
Bethel, RA; Faraj, BA; Fulenwider, JT; Nordlinger, BM; Rudman, D	1
Ali, FM; Faraj, BA; Fulenwider, JT; Henderson, JM; Ivey, GL; Kutner, M; Nordlinger, BM; Rudman, D	1
Baĭkova, VN; Ivanova, VD; Kaverzneva, MM; Levinskiĭ, MB	1
Hannus, ML; Lähdesmäki, P	1
Baĭkova, VN; Ivanova, VD; Raushenbakh, MO	1
Ritsner, MS	1
Angsusingha, K; Punnakanta, L; Tuchinda, C	1
Lazarev, AN; Ostashevskaia, MI	1
Dickens, G; Guroff, G; Letendre, CH	1
Lähdesmäki, P; Oja, SS	1
Iijima, S; Ishii, A; Miyakoshi, T; Musha, M; Odaira, T	1
Hornig, D	1
Crawford, RL	1
Glatt, H	1
Gadbois, P; Gagné, R; Grenier, A; Halket, J; Laberge, C; Lescault, A; Morrisette, J	1
Baĭkova, VN; Rybal'chenko, VG; Shevchenko, VE; Sotnikova, EN; Vares, IM	1
Ivanova, VD; Shevchenko, VE; Sotnikova, EN; Vaĭkova, VN; Vares, IM	1
King, GS; Kvittingen, EA; Leonard, JV; Pettit, BR	1
Harper, AE; Ip, CC	1
Räihä, NC	1
Ellis, BE; Major, G; Zenk, MH	1
D'Iorio, A; Mavrides, C; Whitlow, KJ	1
Friis, J	1
Cohen, HP; Martin, WE	1
Kondrat'ev, VG; Kontsevaia, NG; Koval'skiĭ, GS; Kureeva, RIa; Shapiro, SE	1
Mongia, SP; Sharma, DC; Simlot, MM; Singh, PP	1
Hill, A; Hoag, GN; Zaleski, WA	1
Adolphsen, P; Lenz, H; Siegenthaler, W; Zimmermann, KG	1
Lindblad, B	1
Ericsson, AD; McCann, DS; Szpunar, WE	1
Fisher, MJ; Pogson, CI	1
Lähdesmäki, P	1
Morrissey, JH	1
Baĭkova, VN; Balakirev, SA; Ivanova, VD; Maiakova, SA; Vares, IM	1
Fällström, SP; Lindblad, B; Steen, G	1
Gagné, R; Grenier, A; Laberge, C; Lescault, A	1
Ruzafa, C; Sanchez-Amat, A; Solano, F	2
Deutsch, JC; Santhosh-Kumar, CR	1
Takita, H	1
de Bruijn, FJ; Milcamps, A	1
Cole, DJ; Dixon, DP; Edwards, R	1
Carreira, A; Ferreira, LM; Loureiro, V	1
Baetscher, MW; Burlingame, T; Fernández-Cañón, JM; Finegold, M; Gibson, KM; Grompe, M	1
LA DU, BN; ZANNONI, VG	2
KNOX, WE; LeMAY-KNOX, M	1
Arias-Barrau, E; Díaz, E; Fernández, C; Galán, B; García, JL; Luengo, JM; Miñambres, B; Olivera, ER	1
Berger, R; Grompe, M; Jacobs, SM; Klomp, LW; Luijerink, MC; Malingré, HE; van Beurden, EA; van den Berg, IE	1
Moran, GR	1
Bernardini, I; Gahl, WA; Gerber, LH; Kaiser-Kupfer, MI; O'Brien, K; Perry, MB; Rubin, BI; Sebring, N; Suwannarat, P; Tsilou, E	1
Akkari, Y; Al-Dhalimy, M; Finegold, M; Fleming, WH; Grompe, M; Held, PK; Jiang, S; Olson, S; Torimaru, Y; Willenbring, H	1
Endo, F; Kimoto, Y; Matsumoto, S; Nakamura, K; Tanaka, Y; Tanoue, A; Tsujimoto, G	1
Brakhage, AA; Gebhardt, P; Heinekamp, T; Kniemeyer, O; Schmaler-Ripcke, J; Sugareva, V; Winkler, R	1
Bernardini, I; Bryant, J; Gahl, WA; Introne, WJ; Kayser, MA; Moylan, E; O'Brien, KE; Perry, MB; Reynolds, JC; Sachdev, V; Suwannarat, P; Troendle, J; Tsilou, E	1
Chen, MY; Gahl, WA; Hannoush, H; Introne, WJ; Kayser, MA; Lee, SJ; O'Brien, K; Sachdev, V; Suwannarat, P	1
Goldstein, J; Lok, ZS; Smith, JA	1
Cameotra, SS; Khan, F; Kumari, M	1
Christensen, P; Davison, AS; Dutton, JJ; Gallagher, JA; Hughes, AT; Milan, AM; Ranganath, LR; Ross, G	2
Davison, AS; Dutton, JJ; Hughes, AT; Milan, AM; Ranganath, LR	1
Ayoob, H; Braconi, D; Briggs, MC; Bygott, H; Christensen, P; Cox, TF; Cronlund, A; Dutton, JJ; Fitzgerald, R; Gallagher, JA; Genovese, F; Hall, AK; Hughes, AT; Imrich, R; Jarvis, JC; Junestrand, C; Kullenberg, T; Laan, D; Le Quan Sang, KH; McCaffrey, J; Milan, AM; Nemethova, M; Olsson, B; Psarelli, EE; Ranganath, LR; Ross, G; Rovensky, J; Rudebeck, M; Santucci, A; Sireau, N; Svensson, L; Szamosi, J; Timmis, OG; van Kan, C; Zatkova, A	1
Chai, B; Chen, X; Qiao, Y; Qiu, C; Wang, H	1
Curtis, S; Davison, AS; Devine, J; Gallagher, JA; Hughes, AT; Khedr, M; Milan, AM; Ranganath, LR; Usher, J	1
Beyersdorf, F; Diab, N; Zeh, W	1
Adam, D	1
Cox, TF; Davison, AS; Gallagher, JA; Hughes, AT; Khedr, M; Milan, AM; Psarelli, EE; Ranganath, LR; Rhodes, NP; Rovensky, J	1
Davison, AS; Gallagher, JA; Hughes, AT; Milan, AM; Ranganath, LR; Sireau, N	1
Arnoux, JB; Braconi, D; Bygott, H; Davison, AS; Fitzgerald, R; Gallagher, JA; Genovese, F; Glasova, H; Hughes, AT; Hughes, JH; Imrich, R; Jarvis, JC; Khedr, M; Laan, D; Le Quan Sang, KH; Luangrath, E; Mankowitz, L; Milan, AM; Norman, BP; Olsson, B; Psarelli, EE; Ranganath, LR; Rhodes, NP; Rudebeck, M; Santucci, A; Shweihdi, E; Sireau, N; Stančík, R; van Kan, C; Zatkova, A	1
Auh, S; Avadhanula, S; Burman, KD; Ciccone, C; Filie, AC; Hannah-Shmouni, F; Introne, WJ; Klubo-Gwiezdzinska, J; Regier, D; Soldin, SJ; Stolze, B	1
Hakamata, H; Kishi, T; Kotani, A; Umemura, T	1
Bhatt, A; Dhyani, R; Hussain, A; Jain, S; Navani, NK; Shankar, K	1
Lorquin, F; Lorquin, J; Orneto, C; Piccerelle, P; Robin, M	1
Berdeli, A; Bozaci, AE; Canda, E; Coker, M; Guvenc, MS; Habif, S; Uçar, SK; Yazici, H	1
Batalov, A; Batalov, Z; Karalilova, R; Kostova, T	1
Arnoux, JB; Bou-Gharios, G; Davison, AS; Gallagher, JA; Hughes, AT; Imrich, R; M, K; Milan, AM; Norman, BP; Olsson, B; Ranganath, LR; Rudebeck, M	1
Havranova, A; Imrich, R; Lukacova, O; Penesova, A; Radikova, Z; Ranganath, L; Sedlakova, J; Vlcek, M; Zanova, E; Zatkova, A	1
Davison, AS; Norman, BP	1

Reviews

9 review(s) available for homogentisic acid and tyrosine

Article	Year
Biochemical basis for nutritional management of preterm infants. Pediatrics, 1974, Volume: 53, Issue:2 Topics: Acetoacetates; Adenosine Triphosphate; Amino Acids; Animals; Brain; Cyclic AMP; Cystathionine; Cystine; Enzyme Induction; Female; Fumarates; Homogentisic Acid; Humans; Hydro-Lyases; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature; Liver; Lyases; Maternal-Fetal Exchange; Methionine; Oxidoreductases; Phenylalanine; Phenylalanine Hydroxylase; Phenylpyruvic Acids; Pregnancy; S-Adenosylmethionine; Transferases; Tyrosine; Tyrosine Transaminase	1974
[Ochronotic arthropathy]. Ugeskrift for laeger, 1973, Dec-03, Volume: 135, Issue:49 Topics: Alkaptonuria; Ascorbic Acid; Cartilage, Articular; Homogentisic Acid; Humans; Joint Diseases; Ochronosis; Oxygenases; Tyrosine	1973
[Alkaptonuria (homogentisic aciduria)]. Ryoikibetsu shokogun shirizu, 1998, Issue:18 Pt 1 Topics: Alkaptonuria; Arthritis; Diagnosis, Differential; Dioxygenases; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Ochronosis; Oxygenases; Phenylalanine; Tyrosine	1998
4-Hydroxyphenylpyruvate dioxygenase. Archives of biochemistry and biophysics, 2005, Jan-01, Volume: 433, Issue:1 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Binding Sites; Catalysis; Enzyme Activation; Enzyme Inhibitors; Ferrous Compounds; Holoenzymes; Homogentisic Acid; Humans; Hydroxylation; Kinetics; Models, Molecular; Models, Structural; Molecular Structure; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Pseudomonas fluorescens; Spectrum Analysis, Raman; Streptomyces; Substrate Specificity; Tyrosine	2005
Alkaptonuria-associated aortic stenosis. Journal of cardiac surgery, 2013, Volume: 28, Issue:4 Topics: Aged; Alkaptonuria; Aortic Valve; Aortic Valve Stenosis; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Homogentisic Acid; Humans; Male; Middle Aged; Myocardium; Treatment Outcome; Tyrosine	2013
Alkaptonuria - Many questions answered, further challenges beckon. Annals of clinical biochemistry, 2020, Volume: 57, Issue:2 Topics: Alkaptonuria; Animals; Cyclohexanones; Disease Models, Animal; Enzyme Inhibitors; Homogentisic Acid; Humans; Mice; Nitrobenzoates; Tyrosine	2020
New insights and advances on pyomelanin production: from microbial synthesis to applications. Journal of industrial microbiology & biotechnology, 2022, Jul-30, Volume: 49, Issue:4 Topics: Homogentisic Acid; Humans; Melanins; Pigmentation; Tyrosine	2022
Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review. Rheumatology international, 2022, Volume: 42, Issue:12 Topics: Aged; Alkaptonuria; Ascorbic Acid; Cartilage Diseases; Dioxygenases; Homogentisic Acid; Humans; Joint Diseases; Ochronosis; Osteoarthritis; Quality of Life; Spondylarthropathies; Tyrosine	2022
Alkaptonuria - Past, present and future. Advances in clinical chemistry, 2023, Volume: 114 Topics: Alkaptonuria; Animals; Homogentisic Acid; Humans; Mice; Quality of Life; Tyrosine; Tyrosinemias	2023

Trials

3 trial(s) available for homogentisic acid and tyrosine

Article	Year
A 3-year randomized therapeutic trial of nitisinone in alkaptonuria. Molecular genetics and metabolism, 2011, Volume: 103, Issue:4 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Adult; Alkaptonuria; Cyclohexanones; Homogentisic Acid; Humans; Middle Aged; Nitrobenzoates; Prospective Studies; Tyrosine	2011
Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid Annals of the rheumatic diseases, 2016, Volume: 75, Issue:2 Topics: Adult; Alkaptonuria; Cyclohexanones; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Homogentisic Acid; Humans; Male; Middle Aged; Nitrobenzoates; Research Design; Tyrosine	2016
Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria. Scientific reports, 2019, 07-11, Volume: 9, Issue:1 Topics: Adult; Alkaptonuria; Cyclohexanones; Female; Homogentisic Acid; Humans; Male; Middle Aged; Nitrobenzoates; Phenylalanine; Pigments, Biological; Tandem Mass Spectrometry; Tyrosine	2019

Other Studies

71 other study(ies) available for homogentisic acid and tyrosine

Article	Year
Beneficial effect of methionine and threonine supplements on tyrosine toxicity in rats. Journal of nutritional science and vitaminology, 1976, Volume: 22, Issue:6 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Animals; Body Weight; Caseins; Diet; Homogentisic Acid; Liver; Methionine; Oxygenases; Rats; Threonine; Tyrosine; Tyrosine Transaminase	1976
Perinatal development of the tyrosine oxidizing system. Biology of the neonate, 1978, Volume: 34, Issue:3-4 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Animals; Animals, Newborn; Female; Gestational Age; Homogentisic Acid; Liver; Oxygenases; Pregnancy; Rabbits; Tyrosine; Tyrosine Transaminase	1978
Effect of dietary protein on tyrosine toxicity in the rat. The Journal of nutrition, 1975, Volume: 105, Issue:4 Topics: Animals; Caseins; Dietary Proteins; Glutens; Homogentisic Acid; Hydroxy Acids; Keto Acids; Liver; Male; Oxygenases; Phenols; Phenylpyruvic Acids; Poisoning; Protein Biosynthesis; Rats; Triticum; Tyrosine; Tyrosine Transaminase; Zea mays	1975
[Specificity of tyrosine metabolism depending on the state of melaninogenesis]. Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 80, Issue:8 Topics: Adrenal Glands; Animals; Circadian Rhythm; Homogentisic Acid; Keto Acids; Kidney; Liver; Melanins; Oxidation-Reduction; Phenylpyruvic Acids; Rabbits; Seasons; Skin; Species Specificity; Spleen; Time Factors; Tyrosine; Tyrosine Transaminase	1975
Effect of phenylpyruvate and homogentisate on the formation of aromatic aminoacyl-tRNAs. FEBS letters, 1977, Sep-01, Volume: 81, Issue:1 Topics: Animals; Brain; Cattle; Depression, Chemical; Homogentisic Acid; Phenylalanine; Phenylpyruvic Acids; RNA, Transfer; RNA, Transfer, Amino Acyl; Tryptophan; Tyrosine	1977
Tyrosine metabolism in cirrhosis: acquired alkaptonuria. Surgical forum, 1978, Volume: 29 Topics: Alkaptonuria; Homogentisic Acid; Humans; Liver Cirrhosis; Liver Function Tests; Phenylpyruvic Acids; Tyrosine	1978
Tyrosine metabolism in cirrhosis. The Journal of laboratory and clinical medicine, 1979, Volume: 94, Issue:6 Topics: Adult; Aged; Female; Hepatic Encephalopathy; Homogentisic Acid; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Phenylpyruvic Acids; Tyramine; Tyrosine	1979
[Effect of ascorbic acid on the formation of excess amounts of p-hydroxyphenyllactic acid in lymphosarcoma]. Problemy gematologii i perelivaniia krovi, 1979, Volume: 24, Issue:4 Topics: Ascorbic Acid; Female; Homogentisic Acid; Humans; Lactates; Lymphoma, Non-Hodgkin; Male; Phenylpropionates; Phenylpyruvic Acids; Time Factors; Tyrosine	1979
Effect of aromatic acids on the influx of aromatic amino acids in rat brain slices. Experimental brain research, 1977, Dec-19, Volume: 30, Issue:4 Topics: Animals; Brain; Dose-Response Relationship, Drug; Homogentisic Acid; In Vitro Techniques; Kinetics; Phenylalanine; Phenylpyruvic Acids; Rats; Tryptophan; Tyrosine	1977
[Mechanism of formation of the blastomogenic metabolite of tyrosine - P-hydroxyphenyllactic acid in hemoblastoses]. Problemy gematologii i perelivaniia krovi, 1978, Volume: 23, Issue:5 Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Homogentisic Acid; Humans; Lactates; Leukemia; Lymphoma; Middle Aged; Phenols; Pyruvates; Tyrosine	1978
[Characteristics of tyrosine balance and oxidation in oligophrenia of different origin]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1977, Volume: 77, Issue:3 Topics: Adolescent; Ascorbic Acid; Child; Female; Homogentisic Acid; Humans; Intellectual Disability; Male; Phenylpyruvic Acids; Syndrome; Tyrosine	1977
Intermittent alcaptonuria. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1975, Volume: 58, Issue:5 Topics: Alkaptonuria; Child; Homogentisic Acid; Humans; Male; Oxygenases; Phenylalanine; Tyrosine	1975
[Tyrosine and products of its transformation in the blood and urine of children with euthyroid enlargement of the thyroid gland]. Voprosy okhrany materinstva i detstva, 1975, Volume: 20, Issue:2 Topics: Adolescent; Child; Female; Homogentisic Acid; Humans; Hypertrophy; Male; Puberty; Thyroid Diseases; Thyroid Gland; Tyrosine	1975
Phenylalanine hydroxylase from Pseudomonas sp. (ATCC 11299a). Purification, molecular weight, and influence of tyrosine metabolites on activation and hydroxylation. The Journal of biological chemistry, 1975, Sep-10, Volume: 250, Issue:17 Topics: Enzyme Activation; Homogentisic Acid; Iron; Kinetics; Molecular Weight; Phenylacetates; Phenylalanine; Phenylalanine Hydroxylase; Phenylpyruvic Acids; Pseudomonas; Tyrosine	1975
Effect of aromatic acids on protein synthesis in subcellular preparations from the rat brain. Journal of neurobiology, 1975, Volume: 6, Issue:3 Topics: Animals; Benzoates; Brain; Cell-Free System; Depression, Chemical; Homogentisic Acid; In Vitro Techniques; Nerve Tissue Proteins; Phenylacetates; Phenylalanine; Phenylpyruvic Acids; Rats; Salicylates; Transfer RNA Aminoacylation; Tryptophan; Tyrosine	1975
Studies on the experimental phenylketonuria in rats. The Tohoku journal of experimental medicine, 1975, Volume: 117, Issue:2 Topics: Amino Acids; Animals; Brain Chemistry; Female; Homogentisic Acid; Humans; Liver; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Phenylpyruvic Acids; Pregnancy; Rats; Transaminases; Tyrosine	1975
[Metabolism and the importance of vitamin C in human nutrition]. Bibliotheca nutritio et dieta, 1975, Issue:21 Topics: Animals; Ascorbic Acid; Collagen; Connective Tissue; Contraceptives, Oral; Dopamine; Guinea Pigs; Homogentisic Acid; Humans; Intestinal Absorption; Intestine, Small; Norepinephrine; Nutritional Physiological Phenomena; Nutritional Requirements; Oxalates; Smoking; Tyrosine	1975
Degradation of homogentisate by strains of Bacillus and Moraxella. Canadian journal of microbiology, 1976, Volume: 22, Issue:2 Topics: Acetoacetates; Bacillus; Cell-Free System; Fumarates; Homogentisic Acid; Maleates; Moraxella; Oxygenases; Species Specificity; Tyrosine	1976
Endogenous mutagens derived from amino acids. Mutation research, 1990, Volume: 238, Issue:3 Topics: Acetylcysteine; Amino Acids; Animals; Cells, Cultured; Homogentisic Acid; Levodopa; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Tyrosine	1990
Oral loading of homogentisic acid in controls and in obligate heterozygotes for hereditary tyrosinemia type I. American journal of human genetics, 1990, Volume: 47, Issue:2 Topics: Amino Acid Metabolism, Inborn Errors; Chromatography, Thin Layer; Genetic Carrier Screening; Homogentisic Acid; Humans; Porphobilinogen Synthase; Tyrosine	1990
[Congenital disorders of tyrosine metabolism and their correction in children with tumors]. Voprosy onkologii, 1987, Volume: 33, Issue:11 Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Female; Homogentisic Acid; Humans; Male; Maternal-Fetal Exchange; Neoplasms; Phenylpropionates; Pregnancy; Tyrosine	1987
[Disorders of tyrosine metabolism in children with tumors]. Pediatriia, 1986, Issue:8 Topics: Adolescent; Child; Child, Preschool; Homogentisic Acid; Humans; Infant; Infant, Newborn; Neoplasms; Phenylpropionates; Tyrosine	1986
Concentrations of succinylacetone after homogentisate and tyrosine loading in healthy individuals with low fumarylacetoacetase activity. Clinica chimica acta; international journal of clinical chemistry, 1985, Nov-15, Volume: 152, Issue:3 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Erythrocytes; Female; Fibroblasts; Gas Chromatography-Mass Spectrometry; Genotype; Heptanoates; Heptanoic Acids; Heterozygote; Homogentisic Acid; Homozygote; Humans; Hydrolases; Lymphocytes; Male; Porphobilinogen Synthase; Tyrosine	1985
Effects of dietary protein content and glucagon administration on tyrosine metabolism and tyrosine toxicity in the rat. The Journal of nutrition, 1973, Volume: 103, Issue:11 Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Carbon Radioisotopes; Caseins; Diet; Dietary Proteins; Glucagon; Homogentisic Acid; Liver; Male; Muscles; Oxygenases; Phenols; Phenylpyruvic Acids; Rats; Tyrosine; Tyrosine Transaminase	1973
Preparation of L-tyrosine-ring- 14 C, L-DOPA-ring- 14 C and related metabolites. Analytical biochemistry, 1973, Volume: 53, Issue:2 Topics: Carbon Isotopes; Catechol Oxidase; Catechols; Chromatography, Paper; Cinnamates; Dihydroxyphenylalanine; Escherichia; Homogentisic Acid; Isotope Labeling; Phenols; Plants; Tyrosine	1973
Regulation of the enzymes of tyrosine catabolism in Tetrahymena pyriformis. Biochimica et biophysica acta, 1972, May-16, Volume: 264, Issue:3 Topics: Acetates; Acetoacetates; Animals; Carbon Isotopes; Carboxy-Lyases; Enzyme Repression; Glucose; Glycogen; Guanosine Triphosphate; Homogentisic Acid; Hydrolases; Isocitrates; Isomerases; Lyases; Mixed Function Oxygenases; Oxaloacetates; Oxygenases; Phenols; Phenylpyruvic Acids; Tetrahymena pyriformis; Tyrosine; Tyrosine Transaminase	1972
Column chromatographic separation of acidic and neutral and basic metabolites of tyrosine and dihydroxyphenylalanine. Analytical biochemistry, 1973, Volume: 53, Issue:1 Topics: Benzoates; Carbon Isotopes; Catecholamines; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Ethanol; Glycols; Homogentisic Acid; Lactates; Mandelic Acids; Methods; Phenols; Phenylacetates; Phenylpyruvic Acids; Tritium; Tyramine; Tyrosine	1973
[Aromatic compounds in certain infectious diseases]. Klinicheskaia meditsina, 1973, Volume: 51, Issue:5 Topics: Amino Acids; Erysipelas; Homogentisic Acid; Humans; Indican; Infections; Kynurenine; Liver Diseases; Nicotinic Acids; Phenylpyruvic Acids; Pneumonia; Tryptophan; Tyrosine; Xanthurenates	1973
Dietary infection of homogentisicaciduria in rats. Indian journal of experimental biology, 1973, Volume: 11, Issue:5 Topics: Anemia, Hypochromic; Animals; Diet; Homogentisic Acid; Male; Metabolic Diseases; Rats; Tyrosine	1973
The investigation of aromatic acids in phenylketonuria, alkaptonuria and tyrosinosis using gas-liquid chromatography. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 37 Topics: Acetates; Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Chemistry, Clinical; Chromatography, Gas; Diet Therapy; Ethanol; Hippurates; Homogentisic Acid; Humans; Lactates; Mandelic Acids; Methods; Phenols; Phenylacetates; Phenylketonurias; Phenylpyruvic Acids; Tyrosine	1972
[Alkaptonuria and ochronosis]. Deutsche medizinische Wochenschrift (1946), 1972, Feb-18, Volume: 97, Issue:7 Topics: Alkaptonuria; Chemical Phenomena; Chemistry; Diagnosis, Differential; Female; Germany, West; Homogentisic Acid; Humans; Male; Middle Aged; Ochronosis; Phenols; Phenylalanine; Radiography; Sex Factors; Spinal Diseases; Tyrosine	1972
Radiochemical assays for p-hydroxyphenylpyruvate hydroxylase activity in human liver. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 34, Issue:1 Topics: Adenocarcinoma; Amino Acid Oxidoreductases; Carbon Dioxide; Carbon Isotopes; Cholecystitis; Chromatography, Thin Layer; Cold Temperature; Drug Stability; Homogentisic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Liver Cirrhosis; Liver Neoplasms; Methods; Mixed Function Oxygenases; Phenylpyruvic Acids; Statistics as Topic; Stomach Neoplasms; Tyrosine	1971
Tyrosine metabolism: urinary excretion studies in Parkinsonism. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:1 Topics: Body Weight; Chromatography, Gas; Chromatography, Ion Exchange; Chromatography, Thin Layer; Colorimetry; Dihydroxyphenylalanine; Female; Homogentisic Acid; Humans; Male; Middle Aged; Parkinson Disease; Phenylacetates; Tyrosine; Vanilmandelic Acid	1971
The determination of flux through phenylalanine hydroxylase and homogentisate oxidase in isolated hepatocytes. Bioscience reports, 1984, Volume: 4, Issue:10 Topics: Animals; Cells, Cultured; Dioxygenases; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Kinetics; Liver; Male; Oxygenases; Phenylalanine; Phenylalanine Hydroxylase; Rats; Rats, Inbred Strains; Tyrosine	1984
Inhibition of protein and aminoacyl-tRNA synthesis, and binding and transport sites for aromatic amino acids in the brain in vitro with aromatic acids. The International journal of neuroscience, 1984, Volume: 23, Issue:1 Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cattle; Homogentisic Acid; In Vitro Techniques; Nerve Tissue Proteins; Phenylalanine; Phenylpyruvic Acids; Rats; Rats, Inbred Strains; RNA, Transfer, Amino Acyl; Synaptic Membranes; Synaptosomes; Tritium; Tryptophan; Tyrosine	1984
Deficiency in homogentisic acid oxidase activity associated with the brown phenotype of Dictyostelium discoideum. Journal of general microbiology, 1983, Volume: 129, Issue:4 Topics: Dictyostelium; Dioxygenases; Genotype; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Mutation; Oxygenases; Phenotype; Phenylalanine; Pigmentation; Ploidies; Suppression, Genetic; Tyrosine	1983
[Excretion of the blastomogenic tyrosine metabolite, p-hydroxyphenyllactic acid, in young children with hemoblastoses and their parents]. Problemy gematologii i perelivaniia krovi, 1981, Volume: 26, Issue:4 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Histiocytosis, Langerhans-Cell; Homogentisic Acid; Humans; Infant; Infant, Newborn; Leukemia; Male; Middle Aged; Phenylpropionates; Tyrosine	1981
On the renal tubular damage in hereditary tyrosinemia and on the formation of succinylacetoacetate and succinylacetone. Acta paediatrica Scandinavica, 1981, Volume: 70, Issue:3 Topics: Acetoacetates; Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Child; Heptanoates; Homogentisic Acid; Humans; Infant; Keto Acids; Kidney Diseases; Kidney Tubules; Male; Phenylalanine; Proteinuria; Tyrosine	1981
["Succinylacetone effect' after oral homogentisate loading]. L'union medicale du Canada, 1981, Volume: 110, Issue:7 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Child; Erythrocytes; Female; Heptanoates; Heptanoic Acids; Homogentisic Acid; Humans; Keto Acids; Male; Porphobilinogen Synthase; Sulfides; Tyrosine	1981
Characterization of the melanogenic system in Vibrio cholerae, ATCC 14035. Pigment cell research, 1995, Volume: 8, Issue:3 Topics: Chromatography, High Pressure Liquid; Culture Media; Homogentisic Acid; Hydrogen-Ion Concentration; Kinetics; Melanins; Monophenol Monooxygenase; Phenylpyruvic Acids; Transaminases; Tyrosine; Vibrio cholerae	1995
Quantitation of homogentisic acid in normal human plasma. Journal of chromatography. B, Biomedical applications, 1996, Feb-23, Volume: 677, Issue:1 Topics: Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Gas Chromatography-Mass Spectrometry; Heterozygote; Homogentisic Acid; Humans; Radioisotope Dilution Technique; Tyrosine	1996
Comparative tyrosine degradation in Vibrio cholerae strains. The strain ATCC 14035 as a prokaryotic melanogenic model of homogentisate-releasing cell. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 1998, Volume: 119, Issue:3 Topics: cis-trans-Isomerases; Dioxygenases; Enzyme Induction; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hydrolases; Kinetics; Models, Biological; Oxygenases; Serotyping; Tyrosine; Vibrio cholerae	1998
Identification of a novel nutrient-deprivation-induced Sinorhizobium meliloti gene (hmgA) involved in the degradation of tyrosine. Microbiology (Reading, England), 1999, Volume: 145 ( Pt 4) Topics: Amino Acid Sequence; cis-trans-Isomerases; Dioxygenases; DNA Transposable Elements; Genes, Bacterial; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Luciferases; Molecular Sequence Data; Multigene Family; Mutagenesis; Oxygenases; Sequence Alignment; Sequence Analysis, DNA; Sinorhizobium meliloti; Tyrosine	1999
Characterisation of a zeta class glutathione transferase from Arabidopsis thaliana with a putative role in tyrosine catabolism. Archives of biochemistry and biophysics, 2000, Dec-15, Volume: 384, Issue:2 Topics: Arabidopsis; Arabidopsis Proteins; Base Sequence; cis-trans-Isomerases; Cloning, Molecular; Escherichia coli; Genes, Plant; Glutathione Transferase; Homogentisic Acid; Molecular Sequence Data; Transfection; Tyrosine	2000
Brown pigments produced by Yarrowia lipolytica result from extracellular accumulation of homogentisic acid. Applied and environmental microbiology, 2001, Volume: 67, Issue:8 Topics: Culture Media; Homogentisic Acid; Hydrogen-Ion Concentration; Manganese; Oxidation-Reduction; Pigments, Biological; Saccharomycetales; Tyrosine	2001
Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism. Molecular and cellular biology, 2002, Volume: 22, Issue:13 Topics: Acetoacetates; Animals; cis-trans-Isomerases; Diet; Female; Glutathione; Homogentisic Acid; Male; Mice; Mice, Knockout; Mice, Mutant Strains; Tyrosine	2002
The tyrosine oxidation system of liver. II. Oxidation of p-hydroxyphenylpyruvic acid to homogentisic acid. The Journal of biological chemistry, 1955, Volume: 217, Issue:2 Topics: Acetates; Homogentisic Acid; Liver; Oxidation-Reduction; Phenylpyruvic Acids; Tyrosine	1955
A requirement for catalase in tyrosine metabolism: the oxidation of p-hydroxyphenylpyruvic acid to homogentisic acid. Nature, 1956, Mar-24, Volume: 177, Issue:4508 Topics: Catalase; Homogentisic Acid; Oxidation-Reduction; Oxidoreductases; Tyrosine	1956
The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid. The Biochemical journal, 1951, Volume: 49, Issue:5 Topics: Acetoacetates; Homogentisic Acid; Lipid Metabolism; Liver; Oxidation-Reduction; Phenylpyruvic Acids; Tyrosine	1951
The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida. Journal of bacteriology, 2004, Volume: 186, Issue:15 Topics: Bacterial Proteins; Base Sequence; Biodegradation, Environmental; Gene Expression Regulation, Bacterial; Homogentisic Acid; Molecular Sequence Data; Multigene Family; Phenylacetates; Phenylalanine; Pseudomonas putida; Sequence Analysis, DNA; Tyrosine	2004
Renal proximal tubular cells acquire resistance to cell death stimuli in mice with hereditary tyrosinemia type 1. Kidney international, 2004, Volume: 66, Issue:3 Topics: Animals; Caspase 3; Caspase 9; Caspases; Cyclohexanones; Disease Models, Animal; DNA Fragmentation; Enzyme Inhibitors; Hepatocytes; Homogentisic Acid; Hydrolases; In Situ Nick-End Labeling; Kidney Tubules, Proximal; Mice; Mice, Knockout; Nitrobenzoates; Survival Rate; Tyrosine; Tyrosinemias	2004
Use of nitisinone in patients with alkaptonuria. Metabolism: clinical and experimental, 2005, Volume: 54, Issue:6 Topics: Adult; Aged; Alkaptonuria; Cyclohexanones; Dietary Proteins; Female; Homogentisic Acid; Humans; Male; Middle Aged; Nitrobenzoates; Tyrosine	2005
In vivo genetic selection of renal proximal tubules. Molecular therapy : the journal of the American Society of Gene Therapy, 2006, Volume: 13, Issue:1 Topics: Acute Disease; Animals; Bone Marrow Transplantation; Cell Differentiation; Cell Fusion; Chronic Disease; Disease Models, Animal; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hydrolases; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Knockout; Necrosis; Regeneration; Tyrosine; Urothelium	2006
Gene expression profiles of homogentisate-treated Fah-/- Hpd-/-mice using DNA microarrays. Molecular genetics and metabolism, 2006, Volume: 89, Issue:3 Topics: Animals; Apoptosis; Caspases; Down-Regulation; Female; Gene Expression Profiling; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Hydrolases; Liver; Mice; Mice, Mutant Strains; Neurodegenerative Diseases; Oligonucleotide Array Sequence Analysis; Oxidoreductases; Porphobilinogen Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA; Smad7 Protein; Tyrosine; Tyrosinemias; Up-Regulation	2006
Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus. Applied and environmental microbiology, 2009, Volume: 75, Issue:2 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Antifungal Agents; Aspergillus fumigatus; Fungal Proteins; Gene Deletion; Gene Order; Genes, Fungal; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Melanins; Metabolic Networks and Pathways; Multigene Family; Reactive Oxygen Species; Spectroscopy, Fourier Transform Infrared; Tyrosine	2009
Aortic stenosis and vascular calcifications in alkaptonuria. Molecular genetics and metabolism, 2012, Volume: 105, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alkaptonuria; Aortic Valve Stenosis; Cardiovascular System; Echocardiography; Female; Homogentisic Acid; Humans; Male; Middle Aged; Pigments, Biological; Tyrosine; Vascular Calcification; Young Adult	2012
Biodegradation of the allelopathic chemical m-tyrosine by Bacillus aquimaris SSC5 involves the homogentisate central pathway. PloS one, 2013, Volume: 8, Issue:10 Topics: Allelopathy; Bacillus; Biocatalysis; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Mixed Function Oxygenases; Soil Microbiology; Tyrosine; Tyrosine Transaminase	2013
Urine homogentisic acid and tyrosine: simultaneous analysis by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jul-15, Volume: 963 Topics: Alkaptonuria; Chromatography, Liquid; Homogentisic Acid; Humans; Limit of Detection; Tandem Mass Spectrometry; Tyrosine	2014
Serum concentrations and urinary excretion of homogentisic acid and tyrosine in normal subjects. Clinical chemistry and laboratory medicine, 2015, Volume: 53, Issue:3 Topics: Adult; Female; Healthy Volunteers; Homogentisic Acid; Humans; Male; Middle Aged; Tyrosine	2015
Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry. Annals of clinical biochemistry, 2015, Volume: 52, Issue:Pt 5 Topics: Alkaptonuria; Biomarkers; Chromatography, Liquid; Cyclohexanones; Homogentisic Acid; Humans; Nitrobenzoates; Tandem Mass Spectrometry; Tyrosine	2015
Identification and molecular characterization of the homogentisate pathway responsible for pyomelanin production, the major melanin constituents in Aeromonas media WS. PloS one, 2015, Volume: 10, Issue:3 Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Aeromonas; Biosynthetic Pathways; Chromatography, High Pressure Liquid; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Testing; Homogentisic Acid; Levodopa; Melanins; Mutagenesis; Phenylpyruvic Acids; Pigmentation; Transcription, Genetic; Tyrosine	2015
The effect of nitisinone on homogentisic acid and tyrosine: a two-year survey of patients attending the National Alkaptonuria Centre, Liverpool. Annals of clinical biochemistry, 2017, Volume: 54, Issue:3 Topics: Adult; Aged; Alkaptonuria; Chromatography, Liquid; Cyclohexanones; Drug Administration Schedule; Enzyme Inhibitors; Female; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Longitudinal Studies; Male; Middle Aged; Monitoring, Physiologic; Nitrobenzoates; Tandem Mass Spectrometry; Tyrosine; United Kingdom	2017
Black Aortic Valve Stenosis Reveals a Rare Disorder of Tyrosine Metabolism. Deutsches Arzteblatt international, 2018, 08-06, Volume: 115, Issue:31-32 Topics: Aged; Aortic Valve Stenosis; Cardiac Surgical Procedures; Heart Valve Prosthesis; Homogentisic Acid; Humans; Male; Metabolic Diseases; Tyrosine	2018
A father's fight to help his sons - and fix clinical trials. Nature, 2019, Volume: 565, Issue:7738 Topics: Adolescent; Alkaptonuria; Animals; Autopsy; Child; Clinical Trials as Topic; Compassionate Use Trials; Cyclohexanones; Disease Models, Animal; Disease Progression; Drug Approval; Endpoint Determination; Female; Homogentisic Acid; Humans; Infant; Male; Mice; National Health Programs; National Institutes of Health (U.S.); Nitrobenzoates; Observational Studies as Topic; Off-Label Use; Orphan Drug Production; Rare Diseases; Rats; Sample Size; Tyrosine; Tyrosinemias; United States; United States Food and Drug Administration	2019
Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria. Journal of inherited metabolic disease, 2020, Volume: 43, Issue:4 Topics: Adult; Alkaptonuria; Case-Control Studies; Creatinine; Female; Glomerular Filtration Rate; Homogentisic Acid; Humans; Kidney; Linear Models; Male; Middle Aged; Ochronosis; Phenylalanine; Sex Factors; Tyrosine	2020
Assessment of Thyroid Function in Patients With Alkaptonuria. JAMA network open, 2020, 03-02, Volume: 3, Issue:3 Topics: Adult; Alkaptonuria; Autoantibodies; Autoantigens; Cohort Studies; Female; Homogentisic Acid; Humans; Hyperthyroidism; Hypothyroidism; Iodide Peroxidase; Iron-Binding Proteins; Logistic Models; Male; Middle Aged; Prevalence; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Tyrosine	2020
HPLC with electrochemical detection for determining homogentisic acid and its application to urine from rats fed tyrosine-enriched food. Journal of pharmaceutical and biomedical analysis, 2020, Jul-15, Volume: 186 Topics: Alkaptonuria; Animal Feed; Animals; Chromatography, High Pressure Liquid; Electrochemical Techniques; Food, Fortified; Homogentisic Acid; Limit of Detection; Male; Rats; Rats, Wistar; Tandem Mass Spectrometry; Tyrosine	2020
Homogentisic Acid-Based Whole-Cell Biosensor for Detection of Alkaptonuria Disease. Analytical chemistry, 2021, 03-16, Volume: 93, Issue:10 Topics: Alkaptonuria; Biosensing Techniques; Chromatography, High Pressure Liquid; Homogentisic Acid; Humans; Tyrosine	2021
Long-term follow-up of alkaptonuria patients: single center experience. Journal of pediatric endocrinology & metabolism : JPEM, 2022, Jul-26, Volume: 35, Issue:7 Topics: Adult; Alkaptonuria; Child; Female; Follow-Up Studies; Homogentisate 1,2-Dioxygenase; Homogentisic Acid; Humans; Male; Retrospective Studies; Tyrosine	2022
Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria. Scientific reports, 2022, 09-27, Volume: 12, Issue:1 Topics: Alkaptonuria; Brain Diseases, Metabolic, Inborn; Cyclohexanones; Homogentisic Acid; Humans; Nitrobenzoates; Phenylalanine; Phenylpropionates; Tyrosine; Tyrosinemias	2022
Nutritional interventions for patients with alkaptonuria: A minireview. Endocrine regulations, 2023, Jan-01, Volume: 57, Issue:1 Topics: Alkaptonuria; Homogentisic Acid; Humans; Ochronosis; Tyrosine; Tyrosinemias	2023