homocysteine has been researched along with simvastatin in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 18 (64.29) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| de Lorgeril, M; Lacan, P; Paillard, F; Richard, G; Salen, P | 1 |
| Chehne, F; Kritz, H; Schmid, P; Sinzinger, H | 1 |
| Clayton, A; Cummings, CE; Kirkpatrick, C; Kush, D; Liu, M; MacMahon, M; Robinson, PJ; Tobert, J; Tomiak, RH | 1 |
| Locatelli, S; Lüftjohann, D; Schmidt, HH; Sigit, JI; von Bergmann, K | 1 |
| Brodsky, S; Goligorsky, MS; Iden, C; Lewis, A; Li, H; Rieger, R | 1 |
| Barban, A; Bonaccorsi, G; Donegà, P; Fellin, R; Mollica, G; Pansini, F; Passaro, A; Vigna, GB; Zanca, R | 1 |
| Chasiotis, G; Elisaf, M; Miltiadous, G; Papakostas, J; Seferiadis, K | 1 |
| Chasiotis, G; Elisaf, MS; Kakafika, A; Milionis, HJ; Papakostas, J; Seferiadis, K | 1 |
| Dierkes, J; Luley, C; Westphal, S | 1 |
| Kremastinos, DT; Kyriakides, ZS; Sbarouni, E | 1 |
| Celinska-Lowenhoff, M; Potaczek, DP; Szczeklik, A; Undas, A | 1 |
| Dong, YG; He, ZY; Hu, YZ; Lu, JH; Wu, MX; Zhai, YF; Zhou, Y | 1 |
| Chen, JW; Chen, YH; Huang, SL; Leu, HB; Lin, CP; Liu, PL; Liu, TZ | 1 |
| Armitage, J; Bowman, L; Bulbulia, R; Collins, R; Parish, S | 1 |
| Chen, JW; Chen, YH; Huang, SL; Leu, HB; Lin, CP; Lin, WT; Liu, TZ | 1 |
| Mikael, LG; Rozen, R | 1 |
| Berker, B; Cengiz, SD; Cesur, M; Demirtaş, S; Erdoğan, G; Kaya, C | 1 |
| Corretti, V; Ferrannini, E; Madec, S; Santini, E; Solini, A | 1 |
| Lu, G; Wu, F; Xu, Z | 1 |
| Deneva, TI; Marinov, B; Vladimirova-Kitova, LG | 1 |
| Deneva, TI; Vladimirova-Kitova, LG | 1 |
| Karska-Basta, I; Kubicka-Trząska, A; Romanowska-Dixon, B; Undas, A | 1 |
| Chen, Q; Hsu, YH; Jiang, S; Venners, SA; Wang, X; Xing, H; Xu, X; Zhong, G | 1 |
| Andrade, VL; Eccard, B; Jordão, AA; Sandrim, VC; Sertório, JT; Silva, IF; Silveira, JN; Tanus-Santos, JE; Villela, MP | 1 |
| Kanazawa, I; Notsu, M; Sugimoto, T; Takeno, A; Tanaka, K; Yokomoto-Umakoshi, M | 1 |
| Li, Y; Liu, J; Pang, X; Si, J; Xu, S | 1 |
| Bolevich, S; Jakovljevic, V; Joksimovic, J; Katanic, J; Mihailovic, V; Mijailovic, N; Nikolic, T; Pantic, M; Rosic, G; Selakovic, D; Zivkovic, V | 1 |
| Chen, Y; Dong, H; Li, Y; Wang, S; Wang, X; Wu, J; Xu, Y; Zhang, B | 1 |
1 review(s) available for homocysteine and simvastatin
| Article | Year |
|---|---|
The effect of fibrates and other lipid-lowering drugs on plasma homocysteine levels.
Topics: Fenofibrate; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypolipidemic Agents; Niacin; Risk Factors; Simvastatin | 2004 |
13 trial(s) available for homocysteine and simvastatin
| Article | Year |
|---|---|
Lipid-lowering drugs and homocysteine.
Topics: Amino Acids; Coronary Disease; Double-Blind Method; Fenofibrate; Homocysteine; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Simvastatin | 1999 |
[Unaltered homocysteine levels during simvastatin therapy].
Topics: Adult; Anticholesteremic Agents; Arteriosclerosis; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Female; Homocysteine; Humans; Hyperlipoproteinemia Type II; Male; Middle Aged; Risk Factors; Severity of Illness Index; Sex Factors; Simvastatin; Smoking; Time Factors; Treatment Outcome; Triglycerides | 2000 |
A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH).
Topics: Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Drug Therapy, Combination; Factor Analysis, Statistical; Female; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Placebos; Simvastatin; Triglycerides; Vitamin B 12 | 2000 |
High-dose simvastin (80 mg/day) decreases plasma concentrations of total homocyst(e)ine in patients with hypercholesteromia.
Topics: Cholesterol; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Prospective Studies; Simvastatin; Vitamin B 12 | 2001 |
Simvastatin, transdermal patch, and oral estrogen-progestogen preparation in early-postmenopausal hypercholesterolemic women: a randomized, placebo-controlled clinical trial.
Topics: Administration, Cutaneous; Administration, Oral; Anticholesteremic Agents; Antithrombin III; Apolipoprotein A-I; Apolipoproteins B; Cholesterol, HDL; Cholesterol, LDL; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Fibrinogen; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoprotein(a); Middle Aged; Plasminogen Activator Inhibitor 1; Postmenopause; Progestins; Simvastatin; Treatment Outcome; Triglycerides | 2002 |
Comparative effects of atorvastatin, simvastatin, and fenofibrate on serum homocysteine levels in patients with primary hyperlipidemia.
Topics: Analysis of Variance; Atorvastatin; Blood Glucose; Female; Fenofibrate; Heptanoic Acids; Homocysteine; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Pyrroles; Simvastatin; Uric Acid | 2003 |
The effect of hormone replacement therapy and simvastatin on plasma homocysteine.
Topics: Aged; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Homocysteine; Humans; Hypercholesterolemia; Hypolipidemic Agents; Medroxyprogesterone; Middle Aged; Simvastatin; Time Factors; Treatment Outcome | 2005 |
The I allele of the angiotensin-converting enzyme gene polymorphism may determine an increase in homocysteine levels in fibrate-treated subjects.
Topics: Alleles; Female; Fenofibrate; Genotype; Homocysteine; Humans; Hypolipidemic Agents; Male; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Simvastatin | 2006 |
Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12064 myocardial infarction survivors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Cholesterol; Dose-Response Relationship, Drug; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Retrospective Studies; Simvastatin; Survival Rate; Time Factors; Treatment Outcome; United Kingdom; Vitamin B 12; Vitamin B Complex | 2007 |
Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study.
Topics: Adult; Anticholesteremic Agents; Atorvastatin; Female; Heptanoic Acids; Homocysteine; Humans; Hyperhomocysteinemia; Metabolic Clearance Rate; Polycystic Ovary Syndrome; Pyrroles; Retrospective Studies; Simvastatin; Treatment Outcome | 2009 |
Effect of statins on soluble CD40 ligand in hypercholesterolemic Type 2 diabetic patients.
Topics: Albumins; Biomarkers; Blood Pressure; CD40 Ligand; Diabetes Mellitus, Type 2; Female; Fluorobenzenes; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Interleukin-6; Lipids; Male; Middle Aged; Pyrimidines; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2008 |
Effect of moderate and high-dose simvastatin on asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
Topics: Adult; Arginine; Biomarkers; Bulgaria; Cholesterol, LDL; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Prospective Studies; Severity of Illness Index; Simvastatin; Time Factors; Treatment Outcome | 2011 |
Simvastatin and asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
Topics: Adult; Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Hypercholesterolemia; Lipids; Male; Simvastatin; Treatment Outcome | 2010 |
14 other study(ies) available for homocysteine and simvastatin
| Article | Year |
|---|---|
Homocysteine induces 3-hydroxy-3-methylglutaryl coenzyme a reductase in vascular endothelial cells: a mechanism for development of atherosclerosis?
Topics: Arteriosclerosis; Caveolin 1; Caveolins; Cells, Cultured; Cholesterol; Culture Media, Conditioned; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Induction; Free Radical Scavengers; Gene Expression; Homocysteine; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Metalloporphyrins; Nitric Oxide; Oligonucleotide Array Sequence Analysis; Risk Factors; RNA Stability; RNA, Messenger; Simvastatin; Up-Regulation | 2002 |
Statins and homocysteine.
Topics: Atorvastatin; Heptanoic Acids; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Pyrroles; Risk Factors; Simvastatin | 2003 |
[Effects of simvastatin on homocysteine-induced endothelial dysfunction and inflammatory response].
Topics: Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Female; Homocysteine; Humans; Interleukin-6; Interleukin-8; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2006 |
Cholestin (Monascus purpureus rice) inhibits homocysteine-induced reactive oxygen species generation, nuclear factor-kappaB activation, and vascular cell adhesion molecule-1 expression in human aortic endothelial cells.
Topics: Anti-Inflammatory Agents; Aorta; Atherosclerosis; Biological Products; Cell Adhesion; Chromogranin A; Endothelial Cells; Gene Expression Regulation; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; NF-kappa B; Peptide Fragments; Reactive Oxygen Species; Risk Factors; RNA, Messenger; Simvastatin; U937 Cells; Vascular Cell Adhesion Molecule-1 | 2008 |
Direct effect of statins on homocysteine-induced endothelial adhesiveness: potential impact to human atherosclerosis.
Topics: Aged; Anticholesteremic Agents; Case-Control Studies; Cell Adhesion; Cell Adhesion Molecules; Coronary Artery Disease; Endothelial Cells; Endothelium, Vascular; Female; Homocysteine; Humans; Male; Middle Aged; Pravastatin; Simvastatin | 2008 |
Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS.
Topics: Animals; Apolipoprotein A-I; Cell Line, Tumor; Cholesterol; Female; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes, Mononuclear; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Simvastatin; Transcription Factor RelA | 2008 |
Simvastatin suppresses homocysteine-induced apoptosis in endothelial cells: roles of caspase-3, cIAP-1 and cIAP-2.
Topics: Apoptosis; Caspase 3; Cells, Cultured; Endothelium, Vascular; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Inhibitor of Apoptosis Proteins; Simvastatin | 2009 |
Altered fibrin clot properties in patients with retinal vein occlusion.
Topics: C-Reactive Protein; Coronary Artery Disease; Female; Fenofibrate; Fibrin; Fibrinolysis; Heptanoic Acids; Homocysteine; Humans; Hypersensitivity, Immediate; Laser Coagulation; Lipoprotein(a); Male; Pyrroles; Retinal Vein; Retinal Vein Occlusion; Simvastatin; Tetrahydroisoquinolines; Thrombosis; Venous Thromboembolism; Venous Thrombosis | 2011 |
Effect of simvastatin on plasma homocysteine levels and its modification by MTHFR C677T polymorphism in Chinese patients with primary hyperlipidemia.
Topics: Administration, Oral; Adult; Asian People; Biomarkers; Chi-Square Distribution; China; Chromatography, High Pressure Liquid; Down-Regulation; Female; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymerase Chain Reaction; Polymorphism, Genetic; Simvastatin; Time Factors; Treatment Outcome | 2013 |
Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin.
Topics: Adult; Alleles; Biomarkers; C-Reactive Protein; Cholesterol; Female; Genotype; Homocysteine; Humans; Lipoproteins, LDL; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nitrites; Obesity; Polymorphism, Genetic; Risk Factors; Simvastatin; Thiobarbituric Acid Reactive Substances; Young Adult | 2014 |
Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 2.
Topics: Animals; Apoptosis; Bone Remodeling; Cells, Cultured; Cytoprotection; Gene Expression Regulation, Enzymologic; Homocysteine; Membrane Glycoproteins; Mice; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Osteocytes; Simvastatin | 2016 |
Simvastatin inhibits homocysteine-induced CRP generation via interfering with the ROS-p38/ERK1/2 signal pathway in rat vascular smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; C-Reactive Protein; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Inflammation; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Risk Factors; Signal Transduction; Simvastatin | 2017 |
The anxiolytic effects of atorvastatin and simvastatin on dietary-induced increase in homocysteine levels in rats.
Topics: Animals; Anti-Anxiety Agents; Anticholesteremic Agents; Anxiety Disorders; Atorvastatin; Behavior, Animal; Diet; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Simvastatin | 2019 |
Simvastatin increases circulating endothelial progenitor cells and inhibits the formation of intracranial aneurysms in rats with diet-induced hyperhomocysteinemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Endothelial Progenitor Cells; Endothelium, Vascular; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Intracranial Aneurysm; Male; Rats; Rats, Sprague-Dawley; Simvastatin; Vascular Remodeling | 2021 |