homocysteine has been researched along with sapropterin in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (66.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doshi, SN; Goodfellow, J; Kredan, MB; Lang, D; Lewis, MJ; McDowell, IF; Moat, SJ; Newcombe, RG | 1 |
| Rabelink, TJ; Stroes, E; Verhaar, MC | 1 |
| Badiwala, MV; Dhillon, B; Li, SH; Maitland, A; Rao, V; Verma, S | 1 |
| Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y | 1 |
| Boucher, JL; Brunet, A; David-Dufilho, M; Devynck, MA; Millanvoye, E; Rendu, F; Topal, G | 1 |
| Bryan, RM; Durante, W; Jiang, X; Liao, D; Randhawa, JK; Rumbaut, RE; Schafer, AI; Tan, H; Wang, H; Yang, F; Yang, X | 1 |
| Antoniades, C; Cai, S; Channon, KM; de Bono, J; Lee, J; Leeson, P; Neubauer, S; Pillai, R; Ratnatunga, C; Refsum, H; Shirodaria, C; Warrick, N | 1 |
| Croft, KD; Earl, J; Hu, L; Kanjanapan, Y; Lee, SY; Lim, PS; McKenzie, KU; Miao, Y; Mori, TA; Whitworth, JA; Zhang, Y | 1 |
| Fuchs, D; Ledochowski, M; Neurauter, G; Scholl-Bürgi, S; Schröcksnadel, K; Schubert, C; Sperner-Unterweger, B | 1 |
| Miller, AL | 1 |
| Chen, AF; Feng, J; He, L; Hong, T; Li, F; Liu, J; Liu, S; Mao, J; Wang, G; Wang, X; Yu, J; Zeng, H | 1 |
| Hilge, R; Ide, N; Morihara, N; Papatheodorou, L; Weiss, N | 1 |
| Wang, X; Wen, J; Xiao, C; Zhang, M | 1 |
| Ng, GA; Ng, LL; Yuyun, MF | 1 |
| Lai, B; Luo, Z; Wang, N; Wang, X; Xiao, L; Xie, X; Zhang, Z | 1 |
5 review(s) available for homocysteine and sapropterin
| Article | Year |
|---|---|
Folates and cardiovascular disease.
Topics: Arteriosclerosis; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NAD+); Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Oxidoreductases | 2002 |
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors | 2004 |
Chronic immune stimulation correlates with reduced phenylalanine turnover.
Topics: Animals; Biogenic Monoamines; Biopterins; Homocysteine; Humans; Immune System; Inflammation; Interferon-gamma; Oxidative Stress; Phenylalanine | 2008 |
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
Topics: Antioxidants; Biopterins; Depression; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Neurotransmitter Agents; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2008 |
Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?
Topics: Biopterins; Cardiovascular Diseases; Dietary Supplements; Endothelium, Vascular; Folic Acid; Hemodynamics; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Tetrahydrofolates | 2018 |
2 trial(s) available for homocysteine and sapropterin
| Article | Year |
|---|---|
Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?
Topics: Animals; Biopterins; Cells, Cultured; Coronary Disease; Cross-Over Studies; Cytoplasm; Dietary Supplements; Dilatation, Pathologic; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Injections, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Superoxides; Tetrahydrofolates | 2001 |
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Topics: Acetylcholine; Antioxidants; Atherosclerosis; Biological Availability; Biopterins; Bradykinin; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protein Binding; Superoxides; Tetrahydrofolates | 2006 |
8 other study(ies) available for homocysteine and sapropterin
| Article | Year |
|---|---|
Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction.
Topics: Acetylcholine; Animals; Aorta; Biopterins; Calcimycin; Cells, Cultured; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; In Vitro Techniques; Male; Nitric Oxide; Rats; Rats, Wistar; Superoxides; Vasodilator Agents | 2003 |
Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.
Topics: Antioxidants; Arginine; Ascorbic Acid; Biopterins; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethidium; Fluorescent Dyes; Homocysteine; Humans; L-Lactate Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Pterins; Reactive Nitrogen Species; Superoxides; Thrombin; Time Factors | 2004 |
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
Topics: Animals; Antioxidants; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase C; Pterins; Superoxide Dismutase; Vasodilation | 2005 |
Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Antihypertensive Agents; Biopterins; Blood Pressure; Body Weight; Dexamethasone; Disease Models, Animal; F2-Isoprostanes; Folic Acid; Glucocorticoids; Homocysteine; Hypertension; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Thymus Gland; Time Factors | 2007 |
Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia.
Topics: Adult; Aged; Biopterins; Blood Flow Velocity; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Statistics, Nonparametric | 2010 |
Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation.
Topics: Age Factors; Biopterins; Cell Line; Endothelial Cells; Ethanol; Garlic; Homocysteine; Humans; Nitric Oxide; Plant Extracts; Sulfhydryl Compounds | 2013 |
High‑dose folic acid improves endothelial function by increasing tetrahydrobiopterin and decreasing homocysteine levels.
Topics: Biopterins; Cells, Cultured; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Neopterin; Nitric Oxide | 2014 |
Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine.
Topics: Animals; Aorta, Thoracic; Biopterins; Cattle; Cell Line; Cyclic GMP; Endothelial Cells; Endothelium, Vascular; Homocysteine; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase Type III; Proline; Rats, Sprague-Dawley; Renal Artery; Vasodilation | 2018 |