homocysteine has been researched along with methotrexate in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (19.75) | 18.7374 |
| 1990's | 20 (24.69) | 18.2507 |
| 2000's | 31 (38.27) | 29.6817 |
| 2010's | 10 (12.35) | 24.3611 |
| 2020's | 4 (4.94) | 2.80 |
| Authors | Studies |
|---|---|
| de Blois, MC; Lejeune, J; Peeters, M; Rethore, MO | 1 |
| Christensen, B; Djurhuus, R; Refsum, H; Ueland, PM | 1 |
| Baggott, JE; Morgan, SL; Refsum, H; Ueland, PM | 1 |
| Refsum, H; Ueland, PM; Wesenberg, F | 1 |
| Christensen, B; Refsum, H; Ueland, PM | 1 |
| Helland, S; Refsum, H; Ueland, PM | 1 |
| Allen, RH; Broxson, EH; Kolhouse, JF; Stabler, SP; Stork, LC | 1 |
| Borghi, E; Borowy, F; de Blois, MC; Lejeune, J; Maunoury-Burolla, C; Mir, M; Nicolle, L; Recan, D; Rethoré, MO | 1 |
| Aarsaether, N; Aarsland, A; Berge, RK; Lønning, PE; Refsum, H; Svardal, AM; Ueland, PM | 1 |
| Lillehaug, JR; Male, R; Refsum, H; Ueland, PM | 1 |
| Kvinnsland, S; Refsum, H; Ueland, PM | 1 |
| Gawthorne, JM; Smith, RM | 1 |
| Bertino, JR; Hillcoat, BL | 1 |
| Herbert, V; Metz, J; Waxman, S | 1 |
| Barak, AJ; Beckenhauer, HC; Tuma, DJ | 1 |
| Barak, AJ; Tuma, DJ | 1 |
| Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A; Wick, M | 1 |
| Erbe, RW; Wang, JC | 1 |
| Hilton, MA; Hoffman, JL; Sparks, MK | 1 |
| Barak, AJ; Kemmy, RJ; Tuma, DJ | 1 |
| Tisdale, MJ | 1 |
| Rafter, GW | 1 |
| Pérez de Miguelsanz, J; Ragel, C; Varela-Moreiras, G | 1 |
| Buck, SA; Gurney, JG; Matherly, LH; Ravindranath, Y; Stout, ML; Taub, JW | 1 |
| Blom, HJ; Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM | 1 |
| Kim, YI; Logan, JW; Mason, JB; Roubenoff, R | 1 |
| Kamen, BA; Quinn, CT | 1 |
| Abad, LW; Dellaripa, P; Muldoon, BA; Nadeau, MR; Rosenberg, IH; Roubenoff, R; Selhub, J | 1 |
| Bottiglieri, T; Farrow, A; Griener, JC; Hyland, K; Kamen, BA; Quinn, CT | 1 |
| Fiskerstrand, T; Refsum, H; Ueland, PM | 1 |
| McKendry, RJ | 1 |
| Bottiglieri, T; Griener, JC; Kamen, BA; Quinn, CT | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL | 1 |
| Guttormsen, AB; Lønning, PE; Mella, O; Refsum, H; Ueland, PM | 1 |
| Blom, HJ; Giesendorf, BA; Haagsma, CJ; van de Putte, LB; van Oppenraaij-Emmerzaal, D; van Riel, PL; van't Hof, MA | 1 |
| Gaylor, DW; Gibson, JB; Hine, RJ; James, SJ; Melnyk, S; Pogribna, M; Pogribny, IP; Swenson, DH; Tafoya, DL; Wilson, VL; Yi, P | 1 |
| Erb, N; Kitas, GD | 1 |
| Varela-Moreiras, G | 1 |
| Slot, O | 1 |
| Blom, HJ; Boers, GH; De Boo, TM; Haagsma, CJ; Laan, RF; Thomas, CM; van de Putte, LB; van Ede, AE | 1 |
| Christensen, PB; Ekelund, S; Hansen, H; Jensen, OK; Mollerup, F; Rasmussen, C; Thulstrup, AM | 1 |
| Boiocchi, M; Corona, G; Innocenti, F; Mini, E; Russo, A; Sartor, F; Toffoli, G; Tumolo, S | 1 |
| Cheng, C; Cook, EH; Das, S; Griener, J; Hudson, M; Kishi, S; Pei, D; Pui, CH; Relling, MV; Rubnitz, J; Sandlund, JT | 1 |
| Hänsel, S; Lässig, G; Passauer, J; Pistrosch, F | 1 |
| Hultdin, J; Rantapää-Dahlqvist, S; Wållberg-Jonsson, S; Yxfeldt, A | 1 |
| Cardozo-Pelaez, F; Chan, SL; Chrest, FJ; Emokpae, R; Gorospe, M; Kruman, II; Mattson, MP; Smilenov, L; Wersto, RP | 1 |
| Arning, E; Bottiglieri, T; Griener, JC; Quinn, CT; Winick, NJ | 1 |
| Aamar, S; Abou Atta, I; Ben-Yehuda, A; Berkun, Y; Friedman, G; Grenader, T; Levartovsky, D; Mevorach, D; Orbach, H; Rubinow, A | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA | 1 |
| Ellingsen, T; Hornung, N; Poulsen, JH; Stengaard-Pedersen, K | 1 |
| Radina, M; Sterba, J; Valik, D; Vojtesek, B | 1 |
| Doelman, CJ; Haagsma, CJ; Hoekstra, M; van de Laar, MA | 1 |
| Barut, Y; Direskeneli, H; Inanc, N; Ozdemir, A; Sahinoglu, S; Tarcin, O; Tiftikci, A; Uras, F; Yavuz, S | 1 |
| Ely, SF | 1 |
| Allegrucci, C; Denning, C; Lucas, E; Priddle, H; Sinclair, K; Singh, R; Steele, W; Young, L | 1 |
| Bajciova, V; Demlova, R; Sterba, J; Valik, D | 1 |
| Demlova, R; Dusek, L; Sterba, J; Valik, D | 1 |
| Wolters, M | 1 |
| Chalmers, RJ; Harries, M; Hughes, R; Kirby, B | 1 |
| Chou, CT; Chou, MC; Huang, YC; Jan, MS; Lee, HS; Tsay, G; Tsou, HK; Wei, JC; Yang, CC; Yu, CT | 1 |
| Whitmore, SE | 1 |
| Aamar, S; Abou Atta, I; Arbel, O; Ben-Yehuda, A; Berkun, Y; Dresner-Pollak, R; Friedman, G; Levartovsky, D; Orbach, H; Rubinow, A | 1 |
| Becker, A; Bode, U; Jaehde, U; Linnebank, M; Pels, H; Schlegel, U; Vezmar, S | 1 |
| Celtikci, B; Deng, L; Friedman, HC; James, SJ; Krupenko, NI; Krupenko, SA; Lawrance, AK; Leclerc, D; Melnyk, S; Peterson, AC; Rozen, R | 1 |
| Beckwith, KA; Cole, PD; Kamen, BA; Roychowdhury, S; Smith, AK; Vijayanathan, V | 1 |
| Aktekin, LA; Başkan, BM; Bodur, H; Doğan, YP; Ozoran, K; Sivas, F | 1 |
| Celtikci, B; Lawrance, AK; Rozen, R; Wu, Q | 1 |
| Cole, PD; Gulinello, M; Li, Y; Vijayanathan, V | 1 |
| Ali, N; Cole, PD; Gulinello, M; Vijayanathan, V | 1 |
| Becker, A; Drescher, A; Jaehde, U; Panetta, JC; Pui, CH; Relling, MV; Rühs, H | 1 |
| Adachi, S; Heike, T; Kubota, M; Nakata, R; Shima, M; Takeshita, Y; Watanabe, K | 1 |
| Barendregt, PJ; Calasan, MB; de Jong, PH; de Jonge, R; de Rotte, MC; de Sonnaville, PB; Hazes, JM; Lindemans, J; Pluijm, SM; van der Lubbe, PA; van Zeben, D | 1 |
| Ali, AA; Iqbal, K; Iqbal, MP; Mehboobali, N | 1 |
| Cachia, D; Chi, L; Cykowski, MD; Dabaja, BS; Daver, N; Dinardo, C; Fuller, G; Garg, N; Jabbour, EJ; Jain, N; Kadia, TM; Kamiya-Matsuoka, C; Kantarjian, HM; Konopleva, M; Milgrom, SA; Ohanian, M; Pemmaraju, N; Pinnix, CC; Smith, GL; Woodman, K | 1 |
| Akrout, R; Ayedi, F; Bahloul, Z; Ben Hamad, M; Chaabane, S; Keskes, L; Maalej, A; Marzouk, S; Messedi, M; Rebai, A; Turki, M | 1 |
| Cole, PD; Gulinello, ME; Maxwell, RR; Spira, M; Wen, J; Wolf, AJ | 1 |
| de Jonge, R; Fiocco, M; Heil, SG; Oosterom, N; Pieters, R; Smith, DEC; Tissing, WJE; van den Heuvel-Eibrink, MM; van Zelst, BD | 1 |
| Li, F; Li, J; Shi, L; Shu, J; Sun, X; Tang, J | 1 |
| Cui, YX; Dong, WC; Feng, JY; Guo, JL; Jiang, Y; Wu, XK; Zhang, CX; Zhang, ZQ; Zhao, MQ | 1 |
| Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R | 1 |
| Dave, M; Feuer, P; Ilahi, Z; Janardhan, S; Khariton, M; Romanos-Sirakis, E; Venkataraman, A | 1 |
7 review(s) available for homocysteine and methotrexate
| Article | Year |
|---|---|
Regulation of dihydrofolate reductase and other folate-requiring enzymes.
Topics: Alcohol Oxidoreductases; Animals; Enzyme Induction; Erythrocytes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Guinea Pigs; Homocysteine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia; Leukocytes; Ligases; Methotrexate; Oxidoreductases; Rats; Salmonella typhimurium; Serine; Streptococcus; Tetrahydrofolate Dehydrogenase | 1968 |
Betaine, metabolic by-product or vital methylating agent?
Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates | 1983 |
A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities.
Topics: Acute Disease; Adenosine; Biopterins; Chronic Disease; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Nervous System Diseases; Nucleic Acid Synthesis Inhibitors | 1996 |
The remarkable spectrum of methotrexate toxicities.
Topics: Antirheumatic Agents; Bone Diseases; Central Nervous System; Digestive System; Hematologic Diseases; Homocysteine; Humans; Methotrexate; Rheumatoid Nodule | 1997 |
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Neoplasms | 2004 |
[The significance of diet and associated factors in psoriasis].
Topics: Adolescent; Adult; Alcohol Drinking; Antioxidants; Biomarkers; Case-Control Studies; Child; Controlled Clinical Trials as Topic; Dermatologic Agents; Diet, Vegetarian; Energy Intake; Fasting; Fatty Acids, Omega-3; Female; Fish Oils; Food-Drug Interactions; Glutens; Homocysteine; Humans; Male; Methotrexate; Nutritional Status; Psoriasis; Sex Factors; Vitamin D | 2006 |
10 trial(s) available for homocysteine and methotrexate
| Article | Year |
|---|---|
Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate | 1991 |
Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 1998 |
Kinetics of plasma total homocysteine in patients receiving high-dose methotrexate therapy.
Topics: Adult; Antimetabolites, Antineoplastic; Cerebellar Neoplasms; Folic Acid Antagonists; Homocysteine; Humans; Lymphoma, Non-Hodgkin; Male; Medulloblastoma; Methotrexate; Middle Aged | 1998 |
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Digestive System; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sulfasalazine; Vitamin B 12 | 1999 |
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Daunorubicin; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Linear Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation | 2002 |
Homocysteine in patients with rheumatoid arthritis in relation to inflammation and B-vitamin treatment.
Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dietary Supplements; Double-Blind Method; Female; Health Status; Homocysteine; Humans; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Severity of Illness Index; Surveys and Questionnaires; Vitamin B Complex | 2003 |
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
Topics: Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Brain Chemistry; Central Nervous System Neoplasms; Cytarabine; Excitatory Amino Acids; Female; Homocysteine; Humans; Injections, Intravenous; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Pilot Projects; S-Adenosylmethionine; Statistics, Nonparametric; Time Factors | 2007 |
Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Homocysteine; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Monitoring; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Predictive Value of Tests; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2013 |
64 other study(ies) available for homocysteine and methotrexate
| Article | Year |
|---|---|
Homocysteine and the methotrexate toxicity in trisomy 21.
Topics: Adenosine; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methotrexate | 1991 |
Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Methotrexate; Mice; Neoplasms; Tetrahydrofolates; Thymidine | 1991 |
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1991 |
Methotrexate sensitivity in Down's syndrome: a hypothesis.
Topics: Down Syndrome; Drug Tolerance; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment.
Topics: Adult; Aged; Aged, 80 and over; Fasting; Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Psoriasis; Regression Analysis | 1989 |
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
[Metabolism of monocarbons and trisomy 21: sensitivity to methotrexate].
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methionine; Methotrexate; Mitotic Index; Purines | 1986 |
Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet.
Topics: Analysis of Variance; Animals; Choline Deficiency; Diet; Glutathione; Homocysteine; Kidney; Liver; Male; Methotrexate; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1988 |
Disposition of endogenous homocysteine by mouse fibroblast C3H/10T1/2 Cl 8 and the chemically transformed C3H/10T1/2 MCA Cl 16 cells following methotrexate exposure.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromatography, Ion Exchange; Culture Media; Fibroblasts; Homocysteine; Methotrexate; Methylcholanthrene; Mice; Mice, Inbred C3H; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
Acute and long-term effects of high-dose methotrexate treatment on homocysteine in plasma and urine.
Topics: Adolescent; Adult; Cells, Cultured; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Tetrahydrofolates | 1986 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Homocysteine; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymidine; Transferases; Tritium; Vitamin B 12 Deficiency | 1969 |
Methotrexate hepatotoxicity.
Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides | 1984 |
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.
Topics: Amino Acids, Sulfur; Aminopterin; Animals; Antineoplastic Agents; Carboxypeptidases; Cysteic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Homocysteine; Indicators and Reagents; Leukemia L1210; Liver; Methotrexate; Mice; Structure-Activity Relationship | 1984 |
Folate metabolism in cells from fragile X syndrome patients and carriers.
Topics: Adolescent; Adult; Aged; Cell Line; Child; Clone Cells; Culture Media; Drug Resistance; Female; Fibroblasts; Folic Acid; Fragile X Syndrome; Genetic Markers; Heterozygote; Homocysteine; Humans; Lymphocytes; Male; Methotrexate; Middle Aged; Sex Chromosome Aberrations | 1984 |
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
The effect of methotrexate on homocysteine methylating agents in rat liver.
Topics: Animals; Betaine; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Inbred Strains; Tetrahydrofolates; Time Factors | 1982 |
Methionine metabolism in Walker carcinosarcoma in vitro.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma 256, Walker; Cell Survival; Cells, Cultured; Homocysteine; Methionine; Methotrexate; Sulfhydryl Compounds; Thymidine | 1980 |
Plasma thiols, copper and rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Copper; Cysteine; Glutathione; Homocysteine; Humans; Methionine; Methotrexate; Models, Biological; Sulfhydryl Compounds | 1994 |
Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats.
Topics: Animals; Choline; Choline Deficiency; DNA Modification Methylases; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Wistar | 1995 |
Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Chromosomes, Human, Pair 21; Cystathionine beta-Synthase; Cytarabine; Deoxycytosine Nucleotides; Disease-Free Survival; Down Syndrome; Female; Herpesvirus 4, Human; Homocysteine; Humans; Infant; Infant, Newborn; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid; Male; Methotrexate; Myelodysplastic Syndromes; Neoplastic Stem Cells; Remission, Spontaneous; Survival Rate | 1996 |
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
DNA hypomethylation in inflammatory arthritis: reversal with methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Vitamin B 12 | 1996 |
Abnormal homocysteine metabolism in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Fasting; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer.
Topics: Antimetabolites, Antineoplastic; Central Nervous System; Child; Chromatography, High Pressure Liquid; Cysteine; Excitatory Amino Acids; Homocysteine; Humans; Methotrexate; Neoplasms; Neurotransmitter Agents; Retrospective Studies | 1997 |
Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Anesthetics, Inhalation; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1997 |
Methotrexate, homocysteine, and seizures.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cysteine; Epilepsy, Tonic-Clonic; Homocysteine; Humans; Infant; Male; Methotrexate; Neurotransmitter Agents; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
Topics: Adult; Alcohol Drinking; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyribonucleases, Type II Site-Specific; Diet Surveys; Diet, Reducing; Dietary Supplements; DNA; Down Syndrome; Electrophoresis, Agar Gel; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Risk Factors; Surveys and Questionnaires | 1999 |
Homocysteine modulation as a reason for continuous folic acid supplementation in methotrexate-treated rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Homocysteine; Humans; Methotrexate; Myocardial Ischemia | 2001 |
Changes in plasma homocysteine in arthritis patients starting treatment with low-dose methotrexate subsequently supplemented with folic acid.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Risk Factors | 2001 |
Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Health Status; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome | 2002 |
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; DNA Primers; Female; Genotype; Hematologic Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Platelet Count; Polymerase Chain Reaction; Polymorphism, Genetic | 2003 |
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
Topics: Carrier Proteins; Child; Homocysteine; Humans; Hyperhomocysteinemia; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2003 |
Endothelial dysfunction in young patients with long-term rheumatoid arthritis and low disease activity.
Topics: Acetylcholine; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Pressure; Endothelium, Vascular; Etanercept; Female; Forearm; Heart Rate; Homocysteine; Humans; Immunoglobulin G; Methotrexate; Nitroglycerin; Receptors, Tumor Necrosis Factor; Regional Blood Flow; Severity of Illness Index; Time; Treatment Outcome; Vasodilation; Vasodilator Agents; Women's Health | 2003 |
Cell cycle activation linked to neuronal cell death initiated by DNA damage.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Colchicine; DNA Damage; DNA-Binding Proteins; Etoposide; Female; Homocysteine; Male; Methotrexate; Mice; Nerve Degeneration; Neurons; Protein Serine-Threonine Kinases; Rats; Staurosporine; Tumor Suppressor Proteins | 2004 |
Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid.
Topics: Amino Acids; Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child, Preschool; Epinephrine; Folic Acid; Homocysteine; Humans; Injections, Intraventricular; Male; Methotrexate; Neoplasm Staging | 2004 |
Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2004 |
Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.
Topics: Arthritis, Rheumatoid; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methotrexate; Probability; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Vitamin B 12 | 2004 |
Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 2005 |
Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Methotrexate; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B Complex | 2006 |
Potential risk of a common hereditary thrombophilia and adjuvant chemotherapy for low-stage breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Fatal Outcome; Female; Fluorouracil; Homocysteine; Humans; Methotrexate; Middle Aged; Mutation; Risk; Thrombophilia | 2005 |
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
Topics: Cell Proliferation; Cells, Cultured; DNA Modification Methylases; Embryo, Mammalian; Enzymes; Epigenesis, Genetic; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Methotrexate; Reproductive Techniques, Assisted; S-Adenosylmethionine; Stem Cells | 2005 |
Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate.
Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases, Metabolic; Child; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12; Vitamin B Complex | 2006 |
Folic acid supplementation and methotrexate therapy for psoriasis.
Topics: Dermatologic Agents; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methotrexate; Psoriasis | 2006 |
Plasma homocysteine status in patients with ankylosing spondylitis.
Topics: Antirheumatic Agents; Case-Control Studies; Cross-Sectional Studies; Drug Therapy, Combination; Homocysteine; Humans; Methotrexate; Spondylitis, Ankylosing; Sulfasalazine | 2007 |
Methotrexate and risk for lymphoma.
Topics: Dermatologic Agents; Homocysteine; Humans; Lymphoma; Methotrexate; Psoriasis; Risk Factors | 2007 |
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cross-Sectional Studies; Female; Ferredoxin-NADP Reductase; Genotype; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Pteroylpolyglutamic Acids; Rheumatic Nodule; Severity of Illness Index; Vitamin B 12 | 2007 |
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
Topics: Animals; Cells, Cultured; Female; Gene Expression; Homocysteine; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Diseases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Polymorphism, Single Nucleotide | 2008 |
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult | 2009 |
Serum homocysteine level in patients with ankylosing spondylitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Methotrexate; Middle Aged; Severity of Illness Index; Spondylitis, Ankylosing; Sulfasalazine | 2009 |
Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspase 7; Gene Expression; Homocysteine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Knockout; Spleen | 2009 |
Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine.
Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Cisterna Magna; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Homocysteine; Inflammation Mediators; Injections, Spinal; Male; Memory Disorders; Methotrexate; Motor Activity; Neuropsychological Tests; Psychomotor Performance; Rats; Rats, Long-Evans; Recognition, Psychology; Time Factors | 2010 |
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist.
Topics: Animals; Cognition Disorders; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Folic Acid; Glutamic Acid; Homocysteine; Humans; Injections, Spinal; Male; Memory Disorders; Methotrexate; Rats; Rats, Long-Evans; Recognition, Psychology | 2011 |
Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity.
Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Homocysteine; Humans; Liver Function Tests; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine | 2014 |
Short Communication: Lack of association between MTHFR gene polymorphisms and response to methotrexate treatment in Pakistani patients with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies | 2015 |
Dorsal column myelopathy after intrathecal chemotherapy for leukemia.
Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Electronic Health Records; Female; Folic Acid; Homocysteine; Humans; Injections, Spinal; Leukemia; Magnetic Resonance Imaging; Male; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration | 2017 |
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase; Tunisia; Vitamin B 12 | 2018 |
Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model.
Topics: Animals; Brain; Cell Proliferation; Cognition Disorders; Executive Function; Female; Folic Acid Antagonists; Homocysteine; Male; Memory Disorders; Methotrexate; Microglia; Pattern Recognition, Visual; Rats, Long-Evans; Recognition, Psychology; Spatial Memory | 2018 |
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antidotes; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Infant; Leucovorin; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12 | 2019 |
Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis.
Topics: Arthritis, Rheumatoid; Folic Acid; Homocysteine; Humans; Methotrexate; Spondylitis, Ankylosing | 2020 |
A simple and accurate HFCF-UF method for the analysis of homocysteine, cysteine, cysteinyl-glycine, and glutathione in human blood.
Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Enzyme Inhibitors; Freezing; Glutathione; Homocysteine; Humans; Limit of Detection; Methotrexate; Molecular Structure; Tandem Mass Spectrometry; Temperature; Ultrafiltration; Valproic Acid; Vancomycin | 2021 |
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; Vitamin B 12 | 2023 |
Ketamine as an Adjunct for Treatment of Methotrexate-induced Neurotoxicity.
Topics: Child; Homocysteine; Humans; Ketamine; Methotrexate; Neurotoxicity Syndromes; Paresis | 2022 |