homocysteine and methotrexate

homocysteine has been researched along with methotrexate in 81 studies

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-199016 (19.75)18.7374
1990's20 (24.69)18.2507
2000's31 (38.27)29.6817
2010's10 (12.35)24.3611
2020's4 (4.94)2.80

Authors

AuthorsStudies
de Blois, MC; Lejeune, J; Peeters, M; Rethore, MO1
Christensen, B; Djurhuus, R; Refsum, H; Ueland, PM1
Baggott, JE; Morgan, SL; Refsum, H; Ueland, PM1
Refsum, H; Ueland, PM; Wesenberg, F1
Christensen, B; Refsum, H; Ueland, PM1
Helland, S; Refsum, H; Ueland, PM1
Allen, RH; Broxson, EH; Kolhouse, JF; Stabler, SP; Stork, LC1
Borghi, E; Borowy, F; de Blois, MC; Lejeune, J; Maunoury-Burolla, C; Mir, M; Nicolle, L; Recan, D; Rethoré, MO1
Aarsaether, N; Aarsland, A; Berge, RK; Lønning, PE; Refsum, H; Svardal, AM; Ueland, PM1
Lillehaug, JR; Male, R; Refsum, H; Ueland, PM1
Kvinnsland, S; Refsum, H; Ueland, PM1
Gawthorne, JM; Smith, RM1
Bertino, JR; Hillcoat, BL1
Herbert, V; Metz, J; Waxman, S1
Barak, AJ; Beckenhauer, HC; Tuma, DJ1
Barak, AJ; Tuma, DJ1
Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A; Wick, M1
Erbe, RW; Wang, JC1
Hilton, MA; Hoffman, JL; Sparks, MK1
Barak, AJ; Kemmy, RJ; Tuma, DJ1
Tisdale, MJ1
Rafter, GW1
Pérez de Miguelsanz, J; Ragel, C; Varela-Moreiras, G1
Buck, SA; Gurney, JG; Matherly, LH; Ravindranath, Y; Stout, ML; Taub, JW1
Blom, HJ; Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM1
Kim, YI; Logan, JW; Mason, JB; Roubenoff, R1
Kamen, BA; Quinn, CT1
Abad, LW; Dellaripa, P; Muldoon, BA; Nadeau, MR; Rosenberg, IH; Roubenoff, R; Selhub, J1
Bottiglieri, T; Farrow, A; Griener, JC; Hyland, K; Kamen, BA; Quinn, CT1
Fiskerstrand, T; Refsum, H; Ueland, PM1
McKendry, RJ1
Bottiglieri, T; Griener, JC; Kamen, BA; Quinn, CT1
Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL1
Guttormsen, AB; Lønning, PE; Mella, O; Refsum, H; Ueland, PM1
Blom, HJ; Giesendorf, BA; Haagsma, CJ; van de Putte, LB; van Oppenraaij-Emmerzaal, D; van Riel, PL; van't Hof, MA1
Gaylor, DW; Gibson, JB; Hine, RJ; James, SJ; Melnyk, S; Pogribna, M; Pogribny, IP; Swenson, DH; Tafoya, DL; Wilson, VL; Yi, P1
Erb, N; Kitas, GD1
Varela-Moreiras, G1
Slot, O1
Blom, HJ; Boers, GH; De Boo, TM; Haagsma, CJ; Laan, RF; Thomas, CM; van de Putte, LB; van Ede, AE1
Christensen, PB; Ekelund, S; Hansen, H; Jensen, OK; Mollerup, F; Rasmussen, C; Thulstrup, AM1
Boiocchi, M; Corona, G; Innocenti, F; Mini, E; Russo, A; Sartor, F; Toffoli, G; Tumolo, S1
Cheng, C; Cook, EH; Das, S; Griener, J; Hudson, M; Kishi, S; Pei, D; Pui, CH; Relling, MV; Rubnitz, J; Sandlund, JT1
Hänsel, S; Lässig, G; Passauer, J; Pistrosch, F1
Hultdin, J; Rantapää-Dahlqvist, S; Wållberg-Jonsson, S; Yxfeldt, A1
Cardozo-Pelaez, F; Chan, SL; Chrest, FJ; Emokpae, R; Gorospe, M; Kruman, II; Mattson, MP; Smilenov, L; Wersto, RP1
Arning, E; Bottiglieri, T; Griener, JC; Quinn, CT; Winick, NJ1
Aamar, S; Abou Atta, I; Ben-Yehuda, A; Berkun, Y; Friedman, G; Grenader, T; Levartovsky, D; Mevorach, D; Orbach, H; Rubinow, A1
Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA1
Ellingsen, T; Hornung, N; Poulsen, JH; Stengaard-Pedersen, K1
Radina, M; Sterba, J; Valik, D; Vojtesek, B1
Doelman, CJ; Haagsma, CJ; Hoekstra, M; van de Laar, MA1
Barut, Y; Direskeneli, H; Inanc, N; Ozdemir, A; Sahinoglu, S; Tarcin, O; Tiftikci, A; Uras, F; Yavuz, S1
Ely, SF1
Allegrucci, C; Denning, C; Lucas, E; Priddle, H; Sinclair, K; Singh, R; Steele, W; Young, L1
Bajciova, V; Demlova, R; Sterba, J; Valik, D1
Demlova, R; Dusek, L; Sterba, J; Valik, D1
Wolters, M1
Chalmers, RJ; Harries, M; Hughes, R; Kirby, B1
Chou, CT; Chou, MC; Huang, YC; Jan, MS; Lee, HS; Tsay, G; Tsou, HK; Wei, JC; Yang, CC; Yu, CT1
Whitmore, SE1
Aamar, S; Abou Atta, I; Arbel, O; Ben-Yehuda, A; Berkun, Y; Dresner-Pollak, R; Friedman, G; Levartovsky, D; Orbach, H; Rubinow, A1
Becker, A; Bode, U; Jaehde, U; Linnebank, M; Pels, H; Schlegel, U; Vezmar, S1
Celtikci, B; Deng, L; Friedman, HC; James, SJ; Krupenko, NI; Krupenko, SA; Lawrance, AK; Leclerc, D; Melnyk, S; Peterson, AC; Rozen, R1
Beckwith, KA; Cole, PD; Kamen, BA; Roychowdhury, S; Smith, AK; Vijayanathan, V1
Aktekin, LA; Başkan, BM; Bodur, H; Doğan, YP; Ozoran, K; Sivas, F1
Celtikci, B; Lawrance, AK; Rozen, R; Wu, Q1
Cole, PD; Gulinello, M; Li, Y; Vijayanathan, V1
Ali, N; Cole, PD; Gulinello, M; Vijayanathan, V1
Becker, A; Drescher, A; Jaehde, U; Panetta, JC; Pui, CH; Relling, MV; Rühs, H1
Adachi, S; Heike, T; Kubota, M; Nakata, R; Shima, M; Takeshita, Y; Watanabe, K1
Barendregt, PJ; Calasan, MB; de Jong, PH; de Jonge, R; de Rotte, MC; de Sonnaville, PB; Hazes, JM; Lindemans, J; Pluijm, SM; van der Lubbe, PA; van Zeben, D1
Ali, AA; Iqbal, K; Iqbal, MP; Mehboobali, N1
Cachia, D; Chi, L; Cykowski, MD; Dabaja, BS; Daver, N; Dinardo, C; Fuller, G; Garg, N; Jabbour, EJ; Jain, N; Kadia, TM; Kamiya-Matsuoka, C; Kantarjian, HM; Konopleva, M; Milgrom, SA; Ohanian, M; Pemmaraju, N; Pinnix, CC; Smith, GL; Woodman, K1
Akrout, R; Ayedi, F; Bahloul, Z; Ben Hamad, M; Chaabane, S; Keskes, L; Maalej, A; Marzouk, S; Messedi, M; Rebai, A; Turki, M1
Cole, PD; Gulinello, ME; Maxwell, RR; Spira, M; Wen, J; Wolf, AJ1
de Jonge, R; Fiocco, M; Heil, SG; Oosterom, N; Pieters, R; Smith, DEC; Tissing, WJE; van den Heuvel-Eibrink, MM; van Zelst, BD1
Li, F; Li, J; Shi, L; Shu, J; Sun, X; Tang, J1
Cui, YX; Dong, WC; Feng, JY; Guo, JL; Jiang, Y; Wu, XK; Zhang, CX; Zhang, ZQ; Zhao, MQ1
Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R1
Dave, M; Feuer, P; Ilahi, Z; Janardhan, S; Khariton, M; Romanos-Sirakis, E; Venkataraman, A1

Reviews

7 review(s) available for homocysteine and methotrexate

ArticleYear
Regulation of dihydrofolate reductase and other folate-requiring enzymes.
    Advances in enzyme regulation, 1968, Volume: 6

    Topics: Alcohol Oxidoreductases; Animals; Enzyme Induction; Erythrocytes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Guinea Pigs; Homocysteine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia; Leukocytes; Ligases; Methotrexate; Oxidoreductases; Rats; Salmonella typhimurium; Serine; Streptococcus; Tetrahydrofolate Dehydrogenase

1968
Betaine, metabolic by-product or vital methylating agent?
    Life sciences, 1983, Feb-14, Volume: 32, Issue:7

    Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates

1983
A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 1996, Volume: 44, Issue:9

    Topics: Acute Disease; Adenosine; Biopterins; Chronic Disease; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Nervous System Diseases; Nucleic Acid Synthesis Inhibitors

1996
The remarkable spectrum of methotrexate toxicities.
    Rheumatic diseases clinics of North America, 1997, Volume: 23, Issue:4

    Topics: Antirheumatic Agents; Bone Diseases; Central Nervous System; Digestive System; Hematologic Diseases; Homocysteine; Humans; Methotrexate; Rheumatoid Nodule

1997
Nutritional regulation of homocysteine: effects of drugs.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2001, Volume: 55, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6

2001
Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy.
    Pharmacogenomics, 2004, Volume: 5, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Neoplasms

2004
[The significance of diet and associated factors in psoriasis].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2006, Volume: 57, Issue:11

    Topics: Adolescent; Adult; Alcohol Drinking; Antioxidants; Biomarkers; Case-Control Studies; Child; Controlled Clinical Trials as Topic; Dermatologic Agents; Diet, Vegetarian; Energy Intake; Fasting; Fatty Acids, Omega-3; Female; Fish Oils; Food-Drug Interactions; Glutens; Homocysteine; Humans; Male; Methotrexate; Nutritional Status; Psoriasis; Sex Factors; Vitamin D

2006

Trials

10 trial(s) available for homocysteine and methotrexate

ArticleYear
Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.
    Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:5 Pt 1

    Topics: Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate

1991
Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.
    The Journal of rheumatology, 1998, Volume: 25, Issue:3

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Male; Methotrexate; Middle Aged

1998
Kinetics of plasma total homocysteine in patients receiving high-dose methotrexate therapy.
    Clinical chemistry, 1998, Volume: 44, Issue:9

    Topics: Adult; Antimetabolites, Antineoplastic; Cerebellar Neoplasms; Folic Acid Antagonists; Homocysteine; Humans; Lymphoma, Non-Hodgkin; Male; Medulloblastoma; Methotrexate; Middle Aged

1998
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis.
    Annals of the rheumatic diseases, 1999, Volume: 58, Issue:2

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Digestive System; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sulfasalazine; Vitamin B 12

1999
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:6

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Daunorubicin; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Linear Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation

2002
Homocysteine in patients with rheumatoid arthritis in relation to inflammation and B-vitamin treatment.
    Scandinavian journal of rheumatology, 2003, Volume: 32, Issue:4

    Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dietary Supplements; Double-Blind Method; Female; Health Status; Homocysteine; Humans; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Severity of Illness Index; Surveys and Questionnaires; Vitamin B Complex

2003
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:10

    Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12

2004
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:9

    Topics: Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Brain Chemistry; Central Nervous System Neoplasms; Cytarabine; Excitatory Amino Acids; Female; Homocysteine; Humans; Injections, Intravenous; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Pilot Projects; S-Adenosylmethionine; Statistics, Nonparametric; Time Factors

2007
Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Homocysteine; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:11

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Monitoring; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Predictive Value of Tests; Prospective Studies; Vitamin B 12; Vitamin B 6

2013

Other Studies

64 other study(ies) available for homocysteine and methotrexate

ArticleYear
Homocysteine and the methotrexate toxicity in trisomy 21.
    Cancer chemotherapy and pharmacology, 1991, Volume: 27, Issue:4

    Topics: Adenosine; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methotrexate

1991
Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Methotrexate; Mice; Neoplasms; Tetrahydrofolates; Thymidine

1991
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.
    Cancer research, 1991, Feb-01, Volume: 51, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

1991
Methotrexate sensitivity in Down's syndrome: a hypothesis.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:5

    Topics: Down Syndrome; Drug Tolerance; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment.
    Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Fasting; Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Psoriasis; Regression Analysis

1989
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
    Cancer research, 1989, Nov-01, Volume: 49, Issue:21

    Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
[Metabolism of monocarbons and trisomy 21: sensitivity to methotrexate].
    Annales de genetique, 1986, Volume: 29, Issue:1

    Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methionine; Methotrexate; Mitotic Index; Purines

1986
Effect of methotrexate on homocysteine and other sulfur compounds in tissues of rats fed a normal or a defined, choline-deficient diet.
    Cancer chemotherapy and pharmacology, 1988, Volume: 21, Issue:4

    Topics: Analysis of Variance; Animals; Choline Deficiency; Diet; Glutathione; Homocysteine; Kidney; Liver; Male; Methotrexate; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen

1988
Disposition of endogenous homocysteine by mouse fibroblast C3H/10T1/2 Cl 8 and the chemically transformed C3H/10T1/2 MCA Cl 16 cells following methotrexate exposure.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:1

    Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromatography, Ion Exchange; Culture Media; Fibroblasts; Homocysteine; Methotrexate; Methylcholanthrene; Mice; Mice, Inbred C3H; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine

1986
Acute and long-term effects of high-dose methotrexate treatment on homocysteine in plasma and urine.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: Adolescent; Adult; Cells, Cultured; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Tetrahydrofolates

1986
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
    The Biochemical journal, 1974, Volume: 142, Issue:1

    Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency

1974
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.
    The Journal of clinical investigation, 1969, Volume: 48, Issue:2

    Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Homocysteine; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymidine; Transferases; Tritium; Vitamin B 12 Deficiency

1969
Methotrexate hepatotoxicity.
    Journal of the American College of Nutrition, 1984, Volume: 3, Issue:1

    Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides

1984
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:5

    Topics: Amino Acids, Sulfur; Aminopterin; Animals; Antineoplastic Agents; Carboxypeptidases; Cysteic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Homocysteine; Indicators and Reagents; Leukemia L1210; Liver; Methotrexate; Mice; Structure-Activity Relationship

1984
Folate metabolism in cells from fragile X syndrome patients and carriers.
    American journal of medical genetics, 1984, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Cell Line; Child; Clone Cells; Culture Media; Drug Resistance; Female; Fibroblasts; Folic Acid; Fragile X Syndrome; Genetic Markers; Heterozygote; Homocysteine; Humans; Lymphocytes; Male; Methotrexate; Middle Aged; Sex Chromosome Aberrations

1984
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
    Cancer research, 1983, Volume: 43, Issue:11

    Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates

1983
The effect of methotrexate on homocysteine methylating agents in rat liver.
    Drug-nutrient interactions, 1982, Volume: 1, Issue:4

    Topics: Animals; Betaine; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Inbred Strains; Tetrahydrofolates; Time Factors

1982
Methionine metabolism in Walker carcinosarcoma in vitro.
    European journal of cancer, 1980, Volume: 16, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma 256, Walker; Cell Survival; Cells, Cultured; Homocysteine; Methionine; Methotrexate; Sulfhydryl Compounds; Thymidine

1980
Plasma thiols, copper and rheumatoid arthritis.
    Medical hypotheses, 1994, Volume: 43, Issue:1

    Topics: Animals; Arthritis, Rheumatoid; Copper; Cysteine; Glutathione; Homocysteine; Humans; Methionine; Methotrexate; Models, Biological; Sulfhydryl Compounds

1994
Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats.
    Journal of the American College of Nutrition, 1995, Volume: 14, Issue:5

    Topics: Animals; Choline; Choline Deficiency; DNA Modification Methylases; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Wistar

1995
Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia.
    Blood, 1996, Apr-15, Volume: 87, Issue:8

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Chromosomes, Human, Pair 21; Cystathionine beta-Synthase; Cytarabine; Deoxycytosine Nucleotides; Disease-Free Survival; Down Syndrome; Female; Herpesvirus 4, Human; Homocysteine; Humans; Infant; Infant, Newborn; Leukemia, Megakaryoblastic, Acute; Leukemia, Myeloid; Male; Methotrexate; Myelodysplastic Syndromes; Neoplastic Stem Cells; Remission, Spontaneous; Survival Rate

1996
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
    Biochemical pharmacology, 1996, May-03, Volume: 51, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine

1996
DNA hypomethylation in inflammatory arthritis: reversal with methotrexate.
    The Journal of laboratory and clinical medicine, 1996, Volume: 128, Issue:2

    Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Vitamin B 12

1996
Abnormal homocysteine metabolism in rheumatoid arthritis.
    Arthritis and rheumatism, 1997, Volume: 40, Issue:4

    Topics: Adult; Aged; Arthritis, Rheumatoid; Fasting; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency

1997
Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:8

    Topics: Antimetabolites, Antineoplastic; Central Nervous System; Child; Chromatography, High Pressure Liquid; Cysteine; Excitatory Amino Acids; Homocysteine; Humans; Methotrexate; Neoplasms; Neurotransmitter Agents; Retrospective Studies

1997
Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Anesthetics, Inhalation; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12

1997
Methotrexate, homocysteine, and seizures.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cysteine; Epilepsy, Tonic-Clonic; Homocysteine; Humans; Infant; Male; Methotrexate; Neurotransmitter Agents; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
    The American journal of clinical nutrition, 1999, Volume: 70, Issue:4

    Topics: Adult; Alcohol Drinking; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyribonucleases, Type II Site-Specific; Diet Surveys; Diet, Reducing; Dietary Supplements; DNA; Down Syndrome; Electrophoresis, Agar Gel; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Risk Factors; Surveys and Questionnaires

1999
Homocysteine modulation as a reason for continuous folic acid supplementation in methotrexate-treated rheumatoid arthritis patients.
    Rheumatology (Oxford, England), 2001, Volume: 40, Issue:6

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Homocysteine; Humans; Methotrexate; Myocardial Ischemia

2001
Changes in plasma homocysteine in arthritis patients starting treatment with low-dose methotrexate subsequently supplemented with folic acid.
    Scandinavian journal of rheumatology, 2001, Volume: 30, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Risk Factors

2001
Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation.
    The Journal of rheumatology, 2002, Volume: 29, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Health Status; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome

2002
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.
    International journal of cancer, 2003, Jan-20, Volume: 103, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; DNA Primers; Female; Genotype; Hematologic Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Platelet Count; Polymerase Chain Reaction; Polymorphism, Genetic

2003
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Aug-15, Volume: 21, Issue:16

    Topics: Carrier Proteins; Child; Homocysteine; Humans; Hyperhomocysteinemia; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2003
Endothelial dysfunction in young patients with long-term rheumatoid arthritis and low disease activity.
    Atherosclerosis, 2003, Volume: 170, Issue:1

    Topics: Acetylcholine; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Pressure; Endothelium, Vascular; Etanercept; Female; Forearm; Heart Rate; Homocysteine; Humans; Immunoglobulin G; Methotrexate; Nitroglycerin; Receptors, Tumor Necrosis Factor; Regional Blood Flow; Severity of Illness Index; Time; Treatment Outcome; Vasodilation; Vasodilator Agents; Women's Health

2003
Cell cycle activation linked to neuronal cell death initiated by DNA damage.
    Neuron, 2004, Feb-19, Volume: 41, Issue:4

    Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Colchicine; DNA Damage; DNA-Binding Proteins; Etoposide; Female; Homocysteine; Male; Methotrexate; Mice; Nerve Degeneration; Neurons; Protein Serine-Threonine Kinases; Rats; Staurosporine; Tumor Suppressor Proteins

2004
Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid.
    Journal of pediatric hematology/oncology, 2004, Volume: 26, Issue:6

    Topics: Amino Acids; Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child, Preschool; Epinephrine; Folic Acid; Homocysteine; Humans; Injections, Intraventricular; Male; Methotrexate; Neoplasm Staging

2004
Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:10

    Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic

2004
Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.
    The Journal of rheumatology, 2004, Volume: 31, Issue:12

    Topics: Arthritis, Rheumatoid; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methotrexate; Probability; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Vitamin B 12

2004
Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate.
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:1

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged

2005
Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis.
    Rheumatology international, 2006, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Methotrexate; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B Complex

2006
Potential risk of a common hereditary thrombophilia and adjuvant chemotherapy for low-stage breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Jun-20, Volume: 23, Issue:18

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Fatal Outcome; Female; Fluorouracil; Homocysteine; Humans; Methotrexate; Middle Aged; Mutation; Risk; Thrombophilia

2005
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
    Reproductive biomedicine online, 2005, Volume: 10, Issue:6

    Topics: Cell Proliferation; Cells, Cultured; DNA Modification Methylases; Embryo, Mammalian; Enzymes; Epigenesis, Genetic; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Methotrexate; Reproductive Techniques, Assisted; S-Adenosylmethionine; Stem Cells

2005
Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate.
    Oncology, 2005, Volume: 69, Issue:3

    Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases, Metabolic; Child; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited.
    Clinical chemistry, 2006, Volume: 52, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12; Vitamin B Complex

2006
Folic acid supplementation and methotrexate therapy for psoriasis.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:2

    Topics: Dermatologic Agents; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methotrexate; Psoriasis

2006
Plasma homocysteine status in patients with ankylosing spondylitis.
    Clinical rheumatology, 2007, Volume: 26, Issue:5

    Topics: Antirheumatic Agents; Case-Control Studies; Cross-Sectional Studies; Drug Therapy, Combination; Homocysteine; Humans; Methotrexate; Spondylitis, Ankylosing; Sulfasalazine

2007
Methotrexate and risk for lymphoma.
    Archives of dermatology, 2007, Volume: 143, Issue:5

    Topics: Dermatologic Agents; Homocysteine; Humans; Lymphoma; Methotrexate; Psoriasis; Risk Factors

2007
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
    The Journal of rheumatology, 2007, Volume: 34, Issue:8

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cross-Sectional Studies; Female; Ferredoxin-NADP Reductase; Genotype; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Pteroylpolyglutamic Acids; Rheumatic Nodule; Severity of Illness Index; Vitamin B 12

2007
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
    Pharmacogenetics and genomics, 2008, Volume: 18, Issue:7

    Topics: Animals; Cells, Cultured; Female; Gene Expression; Homocysteine; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Diseases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Polymorphism, Single Nucleotide

2008
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.
    Pediatric neurology, 2009, Volume: 40, Issue:1

    Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult

2009
Serum homocysteine level in patients with ankylosing spondylitis.
    Rheumatology international, 2009, Volume: 29, Issue:12

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Methotrexate; Middle Aged; Severity of Illness Index; Spondylitis, Ankylosing; Sulfasalazine

2009
Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase.
    Anti-cancer drugs, 2009, Volume: 20, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspase 7; Gene Expression; Homocysteine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Knockout; Spleen

2009
Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 95, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Cisterna Magna; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Homocysteine; Inflammation Mediators; Injections, Spinal; Male; Memory Disorders; Methotrexate; Motor Activity; Neuropsychological Tests; Psychomotor Performance; Rats; Rats, Long-Evans; Recognition, Psychology; Time Factors

2010
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist.
    Behavioural brain research, 2011, Dec-01, Volume: 225, Issue:2

    Topics: Animals; Cognition Disorders; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Folic Acid; Glutamic Acid; Homocysteine; Humans; Injections, Spinal; Male; Memory Disorders; Methotrexate; Rats; Rats, Long-Evans; Recognition, Psychology

2011
Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:7

    Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Homocysteine; Humans; Liver Function Tests; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine

2014
Short Communication: Lack of association between MTHFR gene polymorphisms and response to methotrexate treatment in Pakistani patients with rheumatoid arthritis.
    Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:5

    Topics: Adult; Arthritis, Rheumatoid; Female; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies

2015
Dorsal column myelopathy after intrathecal chemotherapy for leukemia.
    American journal of hematology, 2017, Volume: 92, Issue:2

    Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Electronic Health Records; Female; Folic Acid; Homocysteine; Humans; Injections, Spinal; Leukemia; Magnetic Resonance Imaging; Male; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration

2017
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2018, Volume: 67, Issue:8

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase; Tunisia; Vitamin B 12

2018
Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model.
    Neuropharmacology, 2018, 09-01, Volume: 139

    Topics: Animals; Brain; Cell Proliferation; Cognition Disorders; Executive Function; Female; Folic Acid Antagonists; Homocysteine; Male; Memory Disorders; Methotrexate; Microglia; Pattern Recognition, Visual; Rats, Long-Evans; Recognition, Psychology; Spatial Memory

2018
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Adolescent; Antidotes; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Infant; Leucovorin; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12

2019
Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis.
    Clinical rheumatology, 2020, Volume: 39, Issue:11

    Topics: Arthritis, Rheumatoid; Folic Acid; Homocysteine; Humans; Methotrexate; Spondylitis, Ankylosing

2020
A simple and accurate HFCF-UF method for the analysis of homocysteine, cysteine, cysteinyl-glycine, and glutathione in human blood.
    Analytical and bioanalytical chemistry, 2021, Volume: 413, Issue:25

    Topics: Anti-Bacterial Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Enzyme Inhibitors; Freezing; Glutathione; Homocysteine; Humans; Limit of Detection; Methotrexate; Molecular Structure; Tandem Mass Spectrometry; Temperature; Ultrafiltration; Valproic Acid; Vancomycin

2021
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate.
    Zeitschrift fur Rheumatologie, 2023, Volume: 82, Issue:Suppl 1

    Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; Vitamin B 12

2023
Ketamine as an Adjunct for Treatment of Methotrexate-induced Neurotoxicity.
    Journal of pediatric hematology/oncology, 2022, Mar-01, Volume: 44, Issue:2

    Topics: Child; Homocysteine; Humans; Ketamine; Methotrexate; Neurotoxicity Syndromes; Paresis

2022