homocysteine has been researched along with methionine in 1484 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 432 (29.11) | 18.7374 |
| 1990's | 253 (17.05) | 18.2507 |
| 2000's | 487 (32.82) | 29.6817 |
| 2010's | 240 (16.17) | 24.3611 |
| 2020's | 72 (4.85) | 2.80 |
| Authors | Studies |
|---|---|
| Butt, VS; Poulton, JE | 1 |
| Primrose, SB | 1 |
| Das, KC; Herbert, V | 1 |
| Siegel, RC | 1 |
| Griffiths, R; Hemraj, F | 1 |
| Gupta, VJ; Wilcken, DE | 2 |
| Beaton, JM; Bradley, RJ; Smythies, JR | 1 |
| Erbe, RW; Hoffman, RM | 1 |
| Jacobsen, SJ; Mangum, JH; North, JA; Rao, NA | 1 |
| Morzycka, E; Paszewski, A | 1 |
| Benesh, FC; Carl, GF | 1 |
| Mudd, SH | 1 |
| Canfield, CJ; McCormick, GJ; Smith, CC | 2 |
| Kreis, W | 2 |
| Federici, MM; Lotspeich, FJ | 1 |
| Labadie, P | 1 |
| Chrin, LR; Jaffe, JJ | 1 |
| Deeprose, RD; Duncan, GS; Harvey, RJ; Wolberg, G; Zimmerman, TP | 1 |
| Eloranta, TO | 1 |
| Baker, DH; Harter, JM | 2 |
| Poirier, LA; Wilson, MJ | 2 |
| Dow, MJ; Kokkeler, SC; Miller, LT | 1 |
| Hems, R; Krebs, HA; Viña, J | 1 |
| Goodenow, M; Kreis, W | 1 |
| Chanarin, I; Taguchi, H | 1 |
| Günther, E; Herrmann, H; Wehnert, M | 1 |
| Esaki, N; Soda, K; Tanaka, H | 1 |
| Halaseh, A; McConnell, WB; Nigam, SN | 1 |
| Seltmann, G; Voigt, W | 1 |
| Wilcken, B; Wilcken, DE | 1 |
| Hems, R; Krebs, HA | 1 |
| de Robichon-Szulmajster, H; Surdin-Kerjan, Y | 1 |
| McCully, KS | 2 |
| Beaton, JM | 1 |
| Grabski, J; Paszewski, A | 2 |
| Finkelstein, JD; Freeman, JM; Mudd, SH | 1 |
| Amos, HE; Digenis, GA; Little, CO; Mitchell, GE; Schelling, GT; Swintosky, JV | 1 |
| Jaszewski, B; Skupin, J; Warchalewski, J | 1 |
| Lee, H; Redmond, JJ | 1 |
| Ohmori, S | 1 |
| Davis, JW; Flournoy, LD; Phillips, PE | 1 |
| Baker, DH; Katz, RS | 1 |
| Hanna, LM; Taylor, RT | 1 |
| Cheng, FW; Shane, B; Stokstad, EL | 1 |
| Caboche, M | 1 |
| Hieb, WF; Lu, NC; Stokstad, EL | 1 |
| Hamilton, H; Iles, JF | 1 |
| Bowie, L; Crawhall, JC; Gochman, N; Johnson, K; Schneider, JA | 1 |
| Banerjee, RV; González, JC; Huang, S; Matthews, RG; Sumner, JS | 1 |
| Cuénod, M; Do, KQ; Gähwiler, BH; Jiang, ZP; Klancnik, JM | 1 |
| Andersson, A; Brattström, L; Hultberg, B; Israelsson, B; Olsson, A | 1 |
| Barbey, R; Henry, D; Surdin-Kerjan, Y; Thomas, D | 1 |
| Garovic-Kocic, V; Rosenblatt, DS | 1 |
| Tsiftsoglou, AS; Vizirianakis, IS; Wong, W | 1 |
| Andersson, A; Brattström, L; Hamfelt, A; Hultberg, B; Isaksson, A; Israelsson, B | 1 |
| Mansoor, MA; Schneede, J; Svardal, AM; Ueland, PM | 1 |
| Allen, RH; Brass, EP; Marcell, PD; Stabler, SP | 1 |
| Miller, JW; Selhub, J | 1 |
| Hipwell, SE; Liteplo, RG; Lue-Shing, H; Rosenblatt, DS; Sillaots, S | 1 |
| Naito, K; Ono, B | 1 |
| Ambrosi, P; Barlatier, A; Bodard, H; Calaf, R; Charpiot, P; Friggi, A; Garçon, D; Habib, M; Joachim, J; Perrin, S | 1 |
| Dudman, NP; Lynch, J; Wang, JA; Wilcken, DE | 1 |
| Brattström, L; Hultberg, B; Israelsson, B; Lagerstedt, C; Tengborn, L | 1 |
| Refsum, H; Ueland, PM; Wesenberg, F | 1 |
| Christensen, B; Refsum, H; Ueland, PM; Vintermyr, O | 1 |
| Djurhuus, R; Mansoor, MA; Svardal, AM; Ueland, PM | 1 |
| Cherest, H; Surdin-Kerjan, Y; Thomas, D | 1 |
| Cahalane, S; Clarke, R; Daly, L; Fowler, B; Graham, I; Naughten, E; Robinson, K | 1 |
| Abels, J; Ermens, AA; Guttormsen, AB; Lindemans, J; Refsum, H; Rupreht, J; Spijkers, LJ; Ueland, PM | 1 |
| Baumgartner, R; Bubl, R; Kühne, T | 1 |
| Fernandez-Checa, JC; Kaplowitz, N; Maddatu, T; Ookhtens, M | 1 |
| Bagshawe, KD; Bradshaw, T; Mellor, B; Melton, RG; Pedley, RB; Searle, F; Sherwood, RF | 1 |
| Koziorowska, J; Mazurowa, N; Tautt, J | 1 |
| Byerly, KA; Stauffer, GV; Urbanowski, ML | 1 |
| Antoine, E; Breillout, F; Poupon, MF | 1 |
| Andersson, A; Brattström, L; Hultberg, B; Isaksson, A; Israelsson, B | 2 |
| Liteplo, RG | 2 |
| Ariyoshi, S; Fujisue, T; Ichida, S; Yoshioka, K | 1 |
| Bottiglieri, T; Chanarin, I; Metz, J; Van der Westhuyzen, J; Vieira-Makings, E | 1 |
| Baker, DH; Czarnecki, GL | 1 |
| Benyon, RC; Church, MK; Holgate, ST | 1 |
| Szpirer, C; Vanhamme, L | 1 |
| Schalinske, KL; Steele, RD | 1 |
| Ellis, M; Frost, P; Judde, JG | 1 |
| Henning, SM; McKee, RW; Swendseid, ME | 1 |
| Brattström, L; Hultberg, B; Israelsson, B; Tengborn, L | 1 |
| Helland, S; Refsum, H; Ueland, PM | 1 |
| Hipwell, SE; Liteplo, RG | 1 |
| Stauffer, GV; Urbanowski, ML | 3 |
| Plamann, MD; Stauffer, GV | 1 |
| Brot, N; Cai, XY; Maxon, M; Redfield, B; Weissbach, H | 1 |
| Brattström, L; Hultberg, B; Israelsson, B | 1 |
| Refsum, H; Ueland, PM | 1 |
| Gharib, A; Greenland, T; Hamidi, J; Khatchadourian, C; Menezo, Y; Sarda, N | 1 |
| Harvey, PR; Ilson, RG; Strasberg, SM | 1 |
| Dudman, NP; Wilcken, DE; Wiley, VC | 1 |
| Allen, RH; Broxson, EH; Kolhouse, JF; Stabler, SP; Stork, LC | 1 |
| Lapin, IP; Ryzhov, IV | 1 |
| Borghi, E; Borowy, F; de Blois, MC; Lejeune, J; Maunoury-Burolla, C; Mir, M; Nicolle, L; Recan, D; Rethoré, MO | 1 |
| Allard, D; Ceballos, I; Chadefaux, B; Jérôme, H | 1 |
| Dyer, JR; Greenwood, CE | 1 |
| Finkelstein, JD; Harris, BJ; Martin, JJ | 2 |
| Boss, GR | 2 |
| Blom, HJ; Boers, GH; Tangerman, A; Trijbels, JM; van den Elzen, JP; van Roessel, JJ | 1 |
| Begley, JA; Chu, RC; Hall, CA | 1 |
| Griffith, OW | 1 |
| Djurhuus, R; Lillehaug, JR; Male, R; Svardal, AM; Ueland, PM | 1 |
| Allen, RH; Lindenbaum, J; Marcell, PD; Podell, ER; Savage, DG; Stabler, SP | 1 |
| Adams, R; Drachman, DB; Kuncl, RW | 1 |
| Hladovec, J; Mrhová, O; Urbanová, D | 1 |
| Dudman, NP; Robertson, MR; Tyrrell, PA; Wilcken, DE | 1 |
| Ariyoshi, S; Ichida, S; Okazaki, Y; Sobue, K; Tanaka, T; Yoshioka, K | 1 |
| Hoffman, RM; Stern, PH | 2 |
| Cotter, RJ; Hai, TT; Hampton, A; Hyver, KJ; Kappler, F | 1 |
| Stipanuk, MH | 2 |
| Hampton, A; Kappler, F; Vrudhula, VM | 1 |
| Allen, RH; Marcell, PD; Podell, ER; Stabler, SP | 1 |
| Ariyoshi, S; Ichida, S; Moriyama, M; Yoshioka, K | 1 |
| Furukawa, S; Ito, M; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Tomita, T; Toshima, K; Watanabe, T | 1 |
| Ariyoshi, S; Ichida, S; Oda, Y; Oka, H; Yoshioka, K | 1 |
| Duerre, JA; Wallwork, JC | 1 |
| de Weck-Gaudard, D; Fern, EB; Finot, PA; Hunt, M | 1 |
| Carrera, CJ; Carson, DA; Kajander, EO; Kubota, M; Montgomery, JA | 1 |
| Ichida, S | 1 |
| Karasawa, M; Maekawa, T; Omine, M; Yamauchi, H | 1 |
| Djurhuus, R; Refsum, H; Svardal, AM; Ueland, PM | 1 |
| Kvinnsland, S; Refsum, H; Ueland, PM | 1 |
| Cooper, BA; Erbe, RW; Rosenblatt, DS; Thomas, IT; Watkins, D | 1 |
| Brattström, LE; Hardebo, JE; Hultberg, BL | 1 |
| Dudman, NP; Tyrrell, PA; Wilcken, DE | 1 |
| Refsum, H; Svardal, A; Ueland, PM | 1 |
| Auge, J; Christa, L; Kersual, J; Perignon, JL | 1 |
| Boers, GH; Fowler, B; Kleijer, WJ; Kloppenborg, PW; Leermakers, AI; Smals, AG; Trijbels, FJ | 1 |
| Brodie, AE; Reed, DJ | 1 |
| Barak, AJ; Beckenhauer, HC; Tuma, DJ | 2 |
| Bakkeren, JA; Boers, GH; Fowler, B; Kleijer, WJ; Kloppenborg, PW; Schoonderwaldt, HC; Smals, AG; Trijbels, FJ | 1 |
| Chet, I; Lisker, N; Paster, N | 1 |
| Junikiewicz, E; Szydlowska, H | 1 |
| Gawthorne, JM; Smith, RM | 1 |
| Knobloch, G; Sahm, U; Wagner, F | 1 |
| Fukui, S; Nakatani, K; Omori, H; Shimizu, S | 1 |
| Adiga, PR; Sarma, PS | 1 |
| Beaton, JM; Bradley, RJ; Bridgers, WF; McClain, LD; Pegram, GV; Smythies, JR | 1 |
| Ikegami, T; Kodama, H; Oura, T; Yao, K | 1 |
| Foster, MA; Guest, JR; Woods, DD | 1 |
| Ehninger, DJ; Shapiro, SK | 3 |
| Botsford, JL; Parks, LW | 2 |
| Schlenk, F; Zydek-Cwick, CR | 2 |
| Daniel, LJ; Griffiths, JM | 1 |
| Ritari, SJ; Rosales, F; Sakami, W | 1 |
| Salvatore, F; Shapiro, SK; Utili, R; Zappia, V | 1 |
| Naiki, N; Yamagata, S | 1 |
| Kamely, D; Littlefield, JW | 1 |
| Josephs, JA; Magazino, J; Parker, CM; Sprince, H | 1 |
| Nicholas, DJ; Varma, AK | 1 |
| McCully, KS; Spindel, E | 1 |
| Amos, HE; Digenis, GA; Little, CO; Mitchell, GE; Schelling, GT; Tucker, RE | 1 |
| Century, B; Natelson, S; Vorkink, WP | 1 |
| Inukai, S; Sato, K; Shimizu, S | 1 |
| Batra, KK; Buehring, KU; Stokstad, EL | 2 |
| Finkelstein, JD; Harris, BJ; Kyle, WE | 2 |
| Cello, JP; Finkelstein, JD; Kyle, WE | 1 |
| Erbe, RW; Kamely, D; Littlefield, JW | 1 |
| Ashe, H; Chu, F; Clark, BR; Halpern, BC; Halpern, RM; Hardy, DN; Smith, RA | 1 |
| Murphy, JT; Spence, KD | 1 |
| Chou, TC; Talalay, P | 1 |
| Bourel, M; Le Guilly, Y; Lenoir, P; Simon, M | 1 |
| Grabow, WO | 1 |
| Sviatkina, OB; Vel'tishchev, IuE | 1 |
| Flavin, M; Savin, MA; Slaughter, C | 1 |
| Rüdiger, H | 2 |
| Corwin, LM; Rothman, SW | 1 |
| Hoffbrand, AV; Waters, AH | 1 |
| Smith, DA; Whitehouse, JM | 2 |
| Cherest, H; Robichon-Szulmajster, H; Surdin-Kerjan, Y | 1 |
| Hanna, ML; Taylor, RT | 3 |
| Kadner, RJ; Liggins, GL | 1 |
| Collins, JM; Monty, KJ | 1 |
| Balish, E | 2 |
| Antoniewski, J; Cherest, H; de Robichon-Szulmajster, H; Surdin-Kerjan, Y | 1 |
| Greene, RC; Kung, HF; Spears, C; Weissbach, H; Williams, RD | 1 |
| Ferro, AJ; Spence, KD | 1 |
| Jaenicke, L; Rüdiger, H | 2 |
| Finkelstein, JD | 4 |
| Coulter, AW; Lombardini, JB; Talalay, P | 1 |
| Rosenberg, LE | 1 |
| Hutson, NK; Shapiro, SK; Spence, KD | 1 |
| Foster, MA; Pattison, JR; Salem, AR | 1 |
| Foster, MA; Salem, AR | 1 |
| Hakami, N; Sagerson, RN; Scott, CR; Teng, CC | 1 |
| Booth, EM; Mallick, NP; Milewczyk, BK; Robins, AJ | 1 |
| Turner, B; Wilcken, B | 1 |
| Coignet, J; Laurent, B | 1 |
| Birnbaum, J; Kaplan, L; White, RF | 1 |
| Stokstad, EL; Thenen, SW | 1 |
| Boucher, Y; Lachance, RA; Paquin, R | 1 |
| Howell, JN; Jaenicke, L; Sauer, H | 1 |
| Conerly, EB; Mudd, SH; Uhlendorf, BW | 1 |
| Kang, AH; Trelstad, RL | 1 |
| Jung, G; Ottnad, M; Rimpler, M | 1 |
| Hill, LJ; Martin, WG | 1 |
| Finkelstein, JD; Harris, B | 1 |
| Gaull, G; Schaffner, F; Sturman, JA | 1 |
| Fowler, B; Komrower, GM; Robins, AJ; Sardharwalla, IB | 1 |
| Dillon, MJ; England, JM; Gompertz, D; Goodey, PA; Grant, DB; Hussein, HA; Linnell, JC; Matthews, DM; Mudd, SH; Newns, GH; Seakins, JW; Uhlendorf, BW; Wise, IJ | 1 |
| Boguslawski, J; Klopotowski, T; Walczak, W | 1 |
| Taylor, RT; Weissbach, H | 5 |
| Taylor, RT; Weissbach, H; Whitfield, C | 1 |
| Guggenheim, S; Hilton, JL; Owens, LD | 1 |
| Salvatore, F; Shapiro, SK; Zappia, V | 1 |
| Chatagner, F | 1 |
| Weissbach, H; Whitfield, CD | 1 |
| Lawrence, DA; Rowbury, RJ; Smith, DA | 1 |
| Burton, E; Sakami, W; Selhub, J | 1 |
| Harada, T; Murooka, Y; Seto, K | 1 |
| Avadhani, NG; Mehta, BM; Rege, DV | 1 |
| Schlenk, F; Zappia, V; Zydek-Cwick, R | 1 |
| Childs, JD; Smith, DA | 1 |
| Steers, EJ; Weissbach, H; Whitfield, CD | 1 |
| Taylor, RT | 1 |
| Corcino, JJ; Herbert, V; Waxman, S | 1 |
| Schulman, LH | 1 |
| Killick, KA | 2 |
| Lombardini, JB; Talalay, P | 1 |
| Dawes, J; Foster, MA | 1 |
| Smith, DA | 1 |
| King, JS; Wainer, A | 1 |
| Aronovitch, J; Grossowicz, N | 1 |
| Calhoun, DH; Feary, TW | 1 |
| Akamatsu, Y; Law, JH | 1 |
| Cossins, EA; Dodd, WA | 1 |
| Parker, DJ; Wood, HG; Wu, TF | 1 |
| Dewey, VC; Kidder, GW | 1 |
| Hodgson, E; Rock, GC; Sharma, GK | 1 |
| Karahasanoğlu, AM; Ozand, PT | 1 |
| Chatagner, F; Deme, D | 1 |
| Finkelstein, JD; Freeman, JM; Mudd, SH; Shih, VE; Uhlendorf, BW | 1 |
| Draper, MW; Mangum, JH; North, JA | 1 |
| Ngo, TT; Shargool, PD | 1 |
| Miller, SL; Van Trump, JE | 1 |
| Barness, LA; Morrow, G | 1 |
| Applegarth, DA; Auckland, NL; Bozoian, G; Hardwick, DF; Ingram, F | 1 |
| Fowler, B; Robins, AJ; Sardharwalla, IB | 1 |
| Brodie, JD; Burke, GT; Mangum, JH | 2 |
| Hochberg, A; Rahat, M | 1 |
| Giec, A; Jankowska, E; Jaszewski, B; Skupin, J | 1 |
| Finkelstein, JD; Harris, BJ; Kyle, W | 1 |
| Keiser, HR; Lovenberg, W; Sjoerdsma, A; Slavik, M | 1 |
| Fontaine, G | 1 |
| Chen, SS; Duerre, JA; Walgate, JH | 1 |
| Wainwright, T | 2 |
| Foster, MA; Guest, JR; Tejerina, G; Woods, DD | 1 |
| Duerre, JA; Miller, CH | 2 |
| Cauthen, SE; Foster, MA; Woods, DD | 1 |
| Balish, E; Shapiro, SK | 1 |
| Brodie, JD; Huennekens, FM; Kerwar, SS; Mangum, JH; Scrimgeour, KG | 1 |
| Schlesinger, S | 1 |
| Flavin, M; Guggenheim, S | 1 |
| Kjellin-Stråby, K | 1 |
| Phillips, JH | 1 |
| Spatz, R | 1 |
| Bacon, VA; Halpern, B; Jellum, E; Patton, W; Pereira, W | 1 |
| Mangum, JH; Murray, BK; North, JA | 1 |
| Cherest, H; Robichon-Szulmajster, H; Talbot, G | 1 |
| Flavin, M; Kerr, DS | 1 |
| Pande, CS; Rudick, J; Walter, R | 1 |
| Hammar, UB; Strecker, HJ; Volpe, P | 1 |
| Gaull, G; Raiha, NC; Sturman, JA | 1 |
| Foster, MA; Salem, AR; Wilson, RH | 1 |
| Fujii, K; Fukui, S | 1 |
| Levy, H; Morrow, G; Mudd, SH | 1 |
| Hinds, KR; Mudd, SH; Uhlendorf, BW | 1 |
| Goodman, SI; Hammond, KB; Moe, PG; Mudd, SH; Uhlendorf, BW | 1 |
| Hutson, NK; Schlenk, F; Zydek-Cwick, CR | 1 |
| Kerwar, SS; McAuslan, B; Spears, C; Weissbach, H | 1 |
| Shapshak, P | 1 |
| Spence, KD | 1 |
| Demain, AL; White, RF | 1 |
| Balish, E; Mardon, DN | 1 |
| Pittoni, A; Rubaltelli, FF | 1 |
| Bradley, KH; Schneider, JA; Seegmiller, JE | 1 |
| Buettner, M; Parks, LW; Sorsoli, WA | 1 |
| Schlenk, F; Zydek, CR | 1 |
| Mangum, JH; North, JA | 1 |
| Barnard, EA; Glick, DM; Goren, HJ | 1 |
| Duerre, JA | 1 |
| Herbert, V; Metz, J; Waxman, S | 1 |
| Cherest, H; Eichler, F; Robichon-Szulmajster, H | 1 |
| Pittoni, A; Rubaltelli, FF; Sussi, PL | 1 |
| Duerre, JA; Miller, CH; Reams, GG | 1 |
| Schlenk, F; Zappia, V; Zydek-Cwick, CR | 1 |
| Abeles, RH; Jennedy, JP; Levy, HL; Mudd, SH | 1 |
| Flavin, M; Kerr, D | 1 |
| Gjessing, LR; Seip, M; Vellan, EJ | 1 |
| Knudsen, RC; Moore, K; Yall, I | 1 |
| Milner, L; Weissbach, H | 1 |
| Carver, DD; Dennen, DW | 1 |
| Araki, S; Cowen, D; Rowland, LP; Thompson, HL; White, HH | 2 |
| Cossins, EA; Sinha, SK | 1 |
| Gershbein, LL | 1 |
| Khairallah, EA; Wolf, G | 1 |
| Schimke, RN; Spiro, HR; Welch, JP | 1 |
| Dessi, P | 1 |
| Garaza, A; Sellinger, OZ | 1 |
| Gilmour, CM; Nishikawa, SS | 1 |
| Daniel, LJ; Lust, G | 2 |
| Dolman, CL; Dunn, HG; Perry, TL | 1 |
| Coetzee, JN; Prozesky, OW | 1 |
| Klee, WA; Mudd, SH; Ross, PD | 1 |
| Garner, HR; Wiebers, JL | 3 |
| Landi, L; Marchetti, M; Pasquali, P | 1 |
| Guttman, HN | 1 |
| Gaitonde, MK; Gaull, G | 1 |
| Boari, A; Dessi, P | 1 |
| Gaitonde, MK; Gaull, GE | 1 |
| Klee, WA; Mudd, SH | 1 |
| Kutzbach, C; Stokstad, EL | 1 |
| Hansen, S; MacDougall, L; Perry, TL; Warrington, PD | 1 |
| Giovanelli, J; Mudd, SH | 1 |
| Colman, RF | 1 |
| Shapiro, SK; Spence, KD | 1 |
| Awapara, J; Peck, EJ | 1 |
| Boss, GR; Erbe, RW | 1 |
| Ebert, MH; Mudd, SH; Scriver, CR | 1 |
| Dev, VG; Mixon, JC | 1 |
| Hoffman, RM | 2 |
| Hoffman, RM; Jacobsen, SJ | 1 |
| Tisdale, MJ | 5 |
| Coalson, DW; Hoffman, RM; Mecham, JO; Stern, PH | 1 |
| Boss, GR; Pilz, RB | 1 |
| Barak, AJ; Tuma, DJ | 1 |
| Cooper, AJ | 1 |
| Boers, GH; de Groot, PG; Gonsalves, MD; van Aken, WG; van Mourik, JA; Willems, C | 1 |
| Porta, R; Schatz, RA; Sellinger, OZ; Wilens, TE | 1 |
| Beutler, E; Gelbart, T | 1 |
| Barber, JR; Clarke, S | 1 |
| Boers, GH; Drayer, JI; Kloppenborg, PW; Leermakers, AI; Smals, AG; Trijbels, FJ | 1 |
| Boers, GH; Kloppenborg, PW; Leermakers, AI; Smals, AG; Trijbels, FJ | 1 |
| Hoffman, RM; Mecham, JO; Rowitch, D; Stern, PH; Wallace, CD | 1 |
| Gupta, VJ; Reddy, SG; Wilcken, DE | 1 |
| Hoffman, RM; Stern, PH; Wallace, CD | 1 |
| Metz, J; van der Westhuyzen, J | 1 |
| Finkelstein, JD; Martin, JJ | 1 |
| Freed, WJ; Gillin, JC; Luchins, DJ; Taylor, SP; Wyatt, RJ | 1 |
| Graeber, JE; Schulman, JD; Slott, JH; Stuart, MJ; Ulane, RE | 1 |
| Dudman, NP; Wilcken, DE | 1 |
| Myasishcheva, NV; Poirier, LA; Stoner, GD; Wilson, MJ | 1 |
| Eridani, S; Jack, GW; Tisdale, MJ | 1 |
| Poirier, LA; Shivapurkar, N | 1 |
| Bloch, CA; German, DC; Kredich, NM | 1 |
| Anuszewska, EL; Koziorowska, JH; Tautt, JW | 1 |
| Wickramasinghe, SN | 1 |
| Finkelstein, JD; Harris, BJ; Kyle, WE; Martin, JJ | 1 |
| Ozaki, H; Shiio, I | 1 |
| Reddy, GS; Wilcken, DE | 1 |
| Aksamit, RR; Cantoni, GL; Kim, IK | 1 |
| Fowler, B | 3 |
| Hoffman, RM; Mecham, JO; Stern, PH | 1 |
| Koziorowska, J; Pieńkowska, K; Tautt, J | 1 |
| Kimoto, M; Ogawa, T; Sasaoka, K | 1 |
| Eridani, S; Tisdale, M | 1 |
| Gaull, GE; Malloy, MH; Rassin, DK | 1 |
| Bedros, AA; Carmel, R; Goodman, SI; Mace, JW | 1 |
| Balińska, M; Grzelakowska-Sztabert, B | 1 |
| Beatty, PW; Reed, DJ | 1 |
| Cornatzer, WE; Duerre, JA; Hoffman, DR; Marion, DW | 1 |
| Blom, H; Cole, KJ; Peeters, MC; Rousseau, AM; Seller, MJ; van Straaten, HW | 1 |
| Ubbink, JB | 2 |
| Bostom, AG; Ellison, RC; Jacques, PF; Nadeau, MR; Selhub, J; Williams, RR | 1 |
| Garcon, D; Jourdheuil-Rahmani, D; Masset, D; Rahmani, R; Rolland, PH | 1 |
| Applegarth, DA; Seccombe, D; Vallance, HD | 1 |
| Alonso-Aperte, E; Alvarez, L; Caballería, J; Deulofeu, R; Gassó, M; Mato, JM; Rodés, J; Rubio, M; Varela-Moreiras, G | 1 |
| Becker, PJ; Delport, R; Potgieter, H; Ubbink, JB; van der Merwe, A; Vermaak, WJ | 1 |
| Calori, G; D'Angelo, A; Fermo, I; Mazzola, G; Paroni, R; Vigano' D'Angelo, S | 1 |
| Andersson, A; Hultberg, B; Isaksson, A | 1 |
| Amundsen, T; Ueland, PM; Waage, A | 1 |
| Allen, RH; Lindenbaum, J; Stabler, SP | 3 |
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| Boers, GH; de Jong, SC; Devillé, W; Jakobs, C; Pals, G; Rauwerda, JA; Stehouwer, CD; van den Berg, M | 1 |
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| Berger, R; De Meer, K; Dijkstra, DA; Donker, AJ; Jakobs, C; Kulik, W; Reijngoud, DJ; Stehouwer, CD; van Guldener, C | 1 |
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| Aldámiz-Echevarría, L; Couce, ML; Fernández-Marmiesse, A; Hermida, A; Leis, R; Llarena, M; Roca, I; Sánchez-Pintos, P; Vitoria, I | 1 |
| Aris, IM; Chong, MF; Chong, YS; Fortier, MV; Gluckman, PD; Godfrey, KM; Kramer, MS; Lee, YS; Quah, PL; Saw, SM; Tint, MT; van Lee, L; Yap, FK | 1 |
| Augoustides-Savvopoulou, P; Barić, I; Blom, HJ; Chien, YH; Dobbelaere, D; Grünert, SC; Opladen, T; Petković Ramadža, D; Rakić, B; Staufner, C; Wedell, A | 1 |
| Daub, E; Honek, JF; Su, Z; Vaughan, MD | 1 |
| Corthésy, J; Da Silva, L; Dayon, L; Galindo, AN; Guiraud, SP; Kussmann, M; Martin, FP; Montoliu, I | 1 |
| Gogula, S; Guzzo, MB; Jacobs, MR; Jacobsen, DW; Jakubowski, H; Kräutler, B; Nguyen, HT; Nguyen, L; Ogwang, S; Pham, TH; Ruetz, M; Timpona, JL; Wolff, KA; Wyszczelska-Rokiel, M; Zhang, GF | 1 |
| Borowczyk, K; Chwatko, G; Głowacki, R; Jakubowski, H; Kubalczyk, P; Kubalska, J | 1 |
| Andria, G; Ben-Omran, TI; Blom, HJ; Chakrapani, AB; Chapman, KA; Crushell, E; de Almeida, IT; Henderson, MJ; Hochuli, M; Huemer, M; Janssen, MC; Kožich, V; Maillot, F; Mayne, PD; McNulty, J; Morris, AA; Morrison, TM; O'Sullivan, S; Ogier, H; Pavlíková, M; Santra, S; Terry, A; Yap, S | 1 |
| Elsea, S; Jiang, Y; Mistretta, B; Sun, Q | 1 |
| Li, H; Sieff, C | 1 |
| Arun Reddy, R; Dinesh Kumar, B; Diwan, PV; Hemanth Kumar, B; Mahesh Kumar, J | 1 |
| Bandeira, A; Baumgartner, MR; Benoist, JF; Blom, H; Burlina, A; Cerone, R; Couce, ML; Diodato, D; Dionisi-Vici, C; Garcia-Cazorla, A; Huemer, M; Kožich, V; la Marca, G; Pasquini, E; Schiff, M; Schwahn, B; Vilarinho, L; Weisfeld-Adams, JD | 1 |
| Sharma, GS; Singh, LR | 1 |
| Ahrens-Nicklas, RC; Blair, J; Brochi, L; Burfield, J; Cuddapah, S; Ficicioglu, C; Kaplan, P; Whitaker, AM; Yudkoff, M | 1 |
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| Kruger, WD | 1 |
| Padovani, D | 1 |
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| Djuric, D; Jakovljevic, V; Jancic, S; Jeremic, J; Jeremic, N; Matic, S; Milosavljevic, I; Nikolic Turnic, T; Obrenovic, R; Rakocevic, M; Srejovic, I; Zivkovic, V | 1 |
| AbouEl-Ezz, AM; El-Missiry, MA; ElKomy, MA; Othman, AI | 1 |
| Blom, HJ; Castro, R; Esse, R; Koolwijk, P; Tavares de Almeida, I; Teerlink, T | 1 |
| Ray, D; Richardson, BC; Strickland, FM | 1 |
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| Andrejević, L; Cvetković, S; Djurić, D; Hrnčić, D; Jakovljević, V; Kostić, S; Labudović-Borović, M; Mićovic, Ž; Obrenović, R; Stamenković, A; Stanković, S | 1 |
| Chang, D; Hasegawa, H; Ichida, K; Inaba, N; Li, L; Liu, J; Yoshioka, W | 1 |
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| Barić, I; Bártl, J; Baumgartner, MR; Ben-Omran, T; Blasco-Alonso, J; Blom, HJ; Bueno Delgado, MA; Carducci, C; Cassanello, M; Cerone, R; Chrastina, P; Couce, ML; Crushell, E; Delgado Pecellin, C; Dionisi-Vici, C; Dulin, E; Espada, M; Ferino, G; Fingerhut, R; Garcia Jimenez, I; Gleich, F; Gonzalez Gallego, I; González-Irazabal, Y; Gouveia, S; Gramer, G; Huemer, M; Juan Fita, MJ; Karg, E; Keller, R; Klein, J; Kölker, S; Konstantopoulou, V; Kožich, V; la Marca, G; Leão Teles, E; Leuzzi, V; Lilliu, F; Lopez, RM; Lund, AM; Mayne, P; Meavilla, S; Moat, SJ; Morris, AA; Okun, JG; Pasquini, E; Pavlíková, M; Pedron-Giner, CC; Racz, GZ; Ribes, A; Ruiz Gomez, MA; Vilarinho, L; Yahyaoui, R; Zerjav Tansek, M; Zetterström, RH; Zeyda, M | 1 |
| Barroso, M; Castro, R; Esse, R; Tavares de Almeida, I | 1 |
| Cheng, ZY; Du, YF; Shi, HF; Wang, XL; Wei, Y; Wu, TC; Yang, J; Zuo, XF | 1 |
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| Fratiglioni, L; Hooshmand, B; Kalpouzos, G; Kåreholt, I; Kivipelto, M; Mangialasche, F; Refsum, H; Smith, AD; von Arnim, CAF | 1 |
| Goyal, A; Gupta, JK; Narayan Yadav, H; Qureshi, SS | 1 |
| Choi, ET; Cueto, R; Fang, P; Fu, H; Gao, C; Liu, L; Shao, Y; Shen, W; Wang, H; Wu, Q; Yang, WY; Yang, X | 1 |
| Molchan, NS; Polushin, YS; Subbotina, TF; Zhloba, AA | 1 |
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| Deng, M; Guo, W; Jiang, Y; Ma, P; Ma, S; Mao, C; Nie, L; Sun, J; Sun, L; Wang, N; Xiong, J; Yang, A; Zhang, H | 1 |
| Ito, Y; Nishikubo, T; Nishimoto, E; Sakakibara, T | 1 |
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| Feng, C; Ge, Y; Han, L; Jiang, Y; Le, G; Li, B; Shi, Y; Wu, G; Yang, Y | 1 |
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| Jafarpour, F; Jozi, M; Karbalaie, K; Moradi, R; Nasr-Esfahani, MH; Zadegan, FG | 1 |
| Guéant, JL; Hsu, SB; Namour, F; Oussalah, A; Siblini, Y; Zgheib, R | 1 |
| Fiskum, G; Goodfellow, M; Li, F; Miller, C; Puche, A; Ramsue, L; Tchantchou, F | 1 |
| Calderón-Larrañaga, A; Hooshmand, B; Marengoni, A; Refsum, H; Saadeh, M; Smith, AD; Vetrano, DL | 1 |
| Bakırdere, S; Er, EÖ; Şaylan, M; Tekin, Z | 1 |
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| George, AK; Homme, RP; Jovanovic, M; Singh, M; Stanisic, D; Tyagi, N; Tyagi, SC | 1 |
| Adamkov, M; Hnilicova, P; Kalenska, D; Kovalska, M; Lehotsky, J; Tomascova, A | 1 |
| Bublil, EM; Glavin, F; Majtan, T; Park, I | 1 |
| Kožich, V; Stabler, S | 1 |
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| Cynober, L; Deutz, NEP; Engelen, MPKJ; Ligthart-Melis, GC; Simbo, SY; Ten Have, GAM; Thaden, JJ | 1 |
| Bouvier, D; Brailova, M; Minet-Quinard, R; Regnier, A; Sapin, V; Szymanowski, M | 1 |
| Berry, SA; Kerkvliet, SP; Rheault, MN | 1 |
| Jiang, H; Maclean, KN; Mclagan, BM; Phinney, WN; Roede, JR; Stabler, SP | 1 |
| Arkin, AP; Deutschbauer, AM; Price, MN | 1 |
| Bird, JT; Byrum, SD; Miousse, IR; Morehead, LC; Wallis, KF | 1 |
| Aarsand, AK; Aguilera, P; Brunet, M; Deulofeu, R; García-Villoria, J; Gómez-Gómez, À; Pozo, OJ; Sandberg, S; To-Figueras, J; Wijngaard, R | 1 |
| Adamkov, M; Baranovicova, E; Kalenska, D; Kovalska, L; Kovalska, M; Lehotsky, J; Tomascova, A | 1 |
| Bakovic, M; Banton, S; Pezzali, JG; Shoveller, AK; Verbrugghe, A; Wood, KM | 1 |
| Baker, PR; Berry, SA; Ketteridge, D; Kripps, KA; Larson, AA; McCandless, SE; Mirsky, DM; Nguyen, H; Rosenblatt, DS; Sremba, L; Van Hove, JLK; Watkins, D; Wright, EL | 1 |
| Cui, Y; Liao, J; Suguro, R; Yu, Y; Zhao, X; Zhu, YZ | 1 |
| Handa, H; Inagaki, K; Kudo, D; Murota, M; Okawa, A; Shiba, T; Tamura, T; Yasuda, E | 1 |
| Matsha, TE; Raghubeer, S | 1 |
| Akahoshi, N; Ishii, I; Ito, S; Kamata, S; Kamichatani, W; Koizumi, M; Miura, A; Nagata, T; Ohtani, H; Shimonaga, A; Tosaka, Y; Tsushima, M | 1 |
| Guieu, R; Mottola, G; Ruf, J | 1 |
| Cao, Y; Chen, C; Cui, X; Li, Z; Liu, M; Pan, Y; Sun, J; Zhao, F | 1 |
| Ding, N; Jiang, Y; Jiao, Y; Ma, S; Shen, J; Xie, L; Yang, A; Zhang, H | 1 |
| Cao, Y; Cui, X; Liu, M; Ren, G; Xu, J | 1 |
| Milet, A; Vallée, Y; Youssef-Saliba, S | 1 |
| Jakubowski, H; Perła-Kaján, J | 1 |
| Das, S; Jyoti, A; Kaushik, S; Kumar, S; Sharma, V; Singh, S; Srivastava, VK; Yadav, J | 1 |
| Chen, YX; Chen, ZH; Jin, Y; Li, DX; Li, MQ; Li, XY; Liu, YP; Lyu, GY; Song, JQ; Sun, LY; Yang, YL; Zhang, Y; Zhang, YN; Zhu, ZJ | 1 |
| Cariou, B; Croyal, M; Gand, E; Goronflot, T; Hadjadj, S; Jacobi, D; Le May, C; Prieur, X; Ragot, S; Saulnier, PJ; Trochu, JN; Wargny, M | 1 |
| Aa, J; Jiao, Z; Lou, Y; Lu, Z; Peng, Y; Wang, G; Xu, C; Zhang, Y | 1 |
| Abdul Ghani, SAB; Arul, K; Bee, GGB; Cheah, CC; Chow, PKH; Cook, SA; Lim, TR; Pei, HJ; Sandireddy, R; Shekeran, SG; Singh, BK; Singh, MK; Sinha, RA; Suzuki, A; Tikno, K; Tripathi, M; Wang, J; Widjaja, A; Wong, KA; Xiao, RP; Yen, PM; Zhang, X; Zhou, J | 1 |
| Fang, ZZ; Gao, XQ; Jiang, CT; Liu, X; Luo, WM; Su, JY; Wang, WY; Zhang, W; Zhang, ZP | 1 |
| Chen, P; He, Q; Jiang, J; Liu, L; Shi, H; Song, Y; Tang, Y; Wang, B; Zhang, N; Zhou, H; Zhou, Z | 1 |
| Balwani, M; Fanelli, MJ; Gouya, L; Longo, N; Petrides, PE; Phillips, J; Plutzky, J; Rhyee, S; Sardh, E; Sweetser, MT; Ventura, P | 1 |
| Grant, MS; Miesner, MD; Speer, HF; Titgemeyer, EC | 1 |
| Fishchuk, L; Gorovenko, N; Rossokha, Z; Yeroshkina, K | 1 |
| Beltrán, LJ; Bulleid, NJ; Johnstone, IL; Page, AP; Tjahjono, E; Winter, AD | 1 |
| Deng, Y; Kong, J | 1 |
| Alberti, C; Benoist, JF; de Baulny, HO; Feillet, F; Garcia-Segarra, N; Guilmin-Crépon, S; Haignere, J; Imbard, A; Kaguelidou, F; Kuster, A; Magréault, S; Perronneau, I; Schiff, M; Schlemmer, D; Toumazi, A | 1 |
| Subbotina, TF; Zhloba, AA | 1 |
| Araki, T; Dogan, S; Fujioka, M; Hosokawa, T; Ichihashi, K; Ikegame, T; Itokawa, M; Jinde, S; Kasai, K; Kirihara, K; Kondo, S; Koshiyama, D; Marumo, K; Morita, K; Suga, M; Sugishita, K; Tada, M; Taniguchi, K | 1 |
| Dam, J; Hosoi, T; Jockers, R; Kuriya, K; Ozawa, K; Preninka, AI; Yanase, Y; Yazawa, K; Yoshii, M | 1 |
| Jia, W; Liu, N; Shi, L; Wu, X; Xia, Z | 1 |
| Li, C; Liu, W; Lv, B; Qin, J; Xue, J; Xue, Z; Yi, N | 1 |
| Arning, E; Bottiglieri, T; Collado, MC; Demerath, EW; Fields, DA; Isganaitis, E; Lerin, C; Wasek, B | 1 |
| Bah, S; Cisse, K; Coulibaly, B; Dehbi, H; Diakite, B; Diarra, F; Dolo, G; Holl, JL; Hou, L; Joyce, B; Kamate, B; Kassogue, O; Kassogue, Y; Keita, ML; Kim, K; Ly, M; Maiga, M; Murphy, R; Nadifi, S; Sidibe, FM; Sissoko, AS; Sissoko, SB; Teguete, I; Traore, CB; Traore, D; Wang, J | 1 |
| Fang, H; Gong, D; Kang, Q; Tu, X; Xiang, M; Xiao, K; Zhang, D | 1 |
| Bastani, NE; Dagnelie, PC; Elshorbagy, AK; Eussen, SJPM; Grootswagers, P; Kožich, V; Olsen, T; Refsum, H; Retterstøl, K; Stehouwer, CD; Stolt, ETK; Tore, EC; van Greevenbroek, MMJ; Vinknes, KJ | 1 |
| Cui, W; Fang, F; Han, X; Liu, Y | 1 |
| Andexer, JN; Cornelissen, NV; Mohr, MKF; Saleem-Batcha, R | 1 |
| Aijaz, H; Du, F; Franklin, KA; Galanie, S; Guan, S; Hang, J; Huisman, G; Huitt-Roehl, C; Ismaili, MHA; Kruger, WD; Kruse, N; Lee, HO; McCluskie, K; Mitchell, V; Rajkovic, G; Silverman, AP; Skvorak, K; Teadt, L; Zhang, N | 1 |
| Aghalarov, M; Aktuglu-Zeybek, C; Cansever, MS; Kıykım, E; Uygur, E; Zubarioglu, T | 1 |
| Mangoni, AA; Zinellu, A | 1 |
| Clément, A; Clément, P; Menezo, YJR; Viot, G | 1 |
| Gu, J; Lei, C; Zhang, M | 1 |
| Du, YF; Gong, XL; Shi, HF; Wang, XL; Wei, Y; Wu, TC; Zhao, YY | 1 |
| Bhattacharyya, S; Kumar, A; Singh, J | 1 |
| Aggrey, SE; Campos, DB; Felix, TMS; Guerra, RR; Santos, SCL; Silva, JHV; Souza, CS | 1 |
159 review(s) available for homocysteine and methionine
| Article | Year |
|---|---|
Methyl biogenesis.
Topics: Folic Acid; Homocysteine; Humans; Leucovorin; Mental Disorders; Methionine; Methionine Adenosyltransferase; Methylation; S-Adenosylmethionine; Tetrahydrofolates | 1978 |
Diseases of sulphur metabolism: implications for the methionine-homocysteine cycle, and vitamin responsiveness.
Topics: Adolescent; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; Metabolism, Inborn Errors; Methionine; Methylation; Pyridoxine; Sulfur | 1979 |
Folic acid metabolism in vitamin B12 deficiency.
Topics: Animals; Biological Transport; Folic Acid; Folic Acid Deficiency; Glutamates; Homocysteine; Humans; Liver; Methionine; Methyltransferases; Peptide Biosynthesis; Rats; Sheep; Tetrahydrofolates; Vitamin B 12 Deficiency | 1975 |
Homocystine, atherosclerosis and thrombosis: implications for oral contraceptive users.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Arteriosclerosis; Child; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Embolism; Female; Glucose; Homocysteine; Homocystine; Homocystinuria; Humans; Hydro-Lyases; Hyperlipidemias; Methionine; Thrombosis | 1975 |
Methylation & schizophrenia.
Topics: Amines; Amino Acids; Animals; Behavior, Animal; Catecholamines; Cats; Cystathionine; Cysteine; Dihydroxyphenylalanine; Drug Tolerance; Hallucinogens; Homocysteine; Humans; Indoles; Methionine; Methylation; Mice; Schizophrenia; Serine; Taurine | 1975 |
The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine.
Topics: Amino Acid Metabolism, Inborn Errors; Cystathionine; Homocysteine; Humans; Methionine; Methylation; S-Adenosylmethionine | 1992 |
Plasma homocysteine and methionine tolerance in early-onset vascular disease.
Topics: Drug Tolerance; Homocysteine; Humans; Methionine; Risk Factors; Vascular Diseases | 1989 |
Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy.
Topics: Animals; Deficiency Diseases; Female; Homocysteine; Humans; Male; Methionine; Rats; Risk Factors; Sex Factors; Vascular Diseases | 1989 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Disease Models, Animal; Dogs; Estrogens; Folic Acid; Homocysteine; Kynurenine; Methionine; Mice; Neurotransmitter Agents; Prostaglandins; Pyridoxal Phosphate; Quinolinic Acid; Quinolinic Acids; Rats; Seizures; Spinal Cord | 1986 |
Mammalian sulfur amino acid metabolism: an overview.
Topics: Amino Acids, Sulfur; Animals; Cysteine; Homocysteine; Mammals; Methionine | 1987 |
Metabolism of sulfur-containing amino acids.
Topics: Adenosylhomocysteinase; Animals; Carboxy-Lyases; Cysteine; Female; Homocysteine; Humans; Hydrolases; Isoenzymes; Liver; Male; Methionine; Methionine Adenosyltransferase; Methylation; Polyamines; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Taurine; Transaminases | 1986 |
[Sulfate reduction and biosynthesis of sulfur containing amino acids (author's transl)].
Topics: Amino Acids, Sulfur; Bacteria; Cysteine; Feedback; Homocysteine; Hydrogen Sulfide; Methionine; Oxidation-Reduction; Sulfates; Sulfur; Sulfur Acids; Sulfuric Acids; Thiosulfates; Vitamin B 12 | 1974 |
[Hereditary anomalies of methionine metabolism in children].
Topics: Age Factors; Child; Flatfoot; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Intellectual Disability; Kyphosis; Marfan Syndrome; Metabolism, Inborn Errors; Methionine; Scoliosis | 1972 |
Observations on the biochemical basis of megaloblastic anaemia.
Topics: Anemia, Macrocytic; Deoxyuridine; DNA; Erythrocytes, Abnormal; FIGLU Test; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Nervous System Diseases; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymine Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
The biosynthesis of methionine.
Topics: Animals; Apoproteins; Bacteria; Catalysis; Chemical Phenomena; Chemistry; Cobamides; Drug Stability; Enzyme Activation; Escherichia coli; Flavins; Homocysteine; Methionine; Methyltransferases; Molecular Weight; Oxidation-Reduction; Plants; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 | 1973 |
Methionine metabolism in mammals: the biochemical basis for homocystinuria.
Topics: Alcohol Oxidoreductases; Cell-Free System; Cystathionine; Fibroblasts; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Liver; Methionine; Methylation; Methyltransferases; Protein Biosynthesis; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 1974 |
Vitamin-responsive inherited diseases affecting the nervous system.
Topics: Coenzymes; Genotype; Homocysteine; Humans; Metabolism, Inborn Errors; Methionine; Molecular Biology; Mutation; Neurologic Manifestations; Phenotype; Pyridoxine; Vitamin B 12; Vitamins | 1974 |
[Biochemical aspects of some congenital anomalies of the metabolism of sulfur amino acids].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cysteine; Cystinuria; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; L-Serine Dehydratase; Methionine; Rats | 1967 |
Defective vitamin B 12 metabolism in the human being: changes in methionine and methylmalonic acid excretion.
Topics: Amino Acids; Animals; Brain; Coenzymes; Homocysteine; Homocystine; Humans; Infant; Male; Malonates; Metabolic Diseases; Methionine; Rats; Vitamin B 12 | 1969 |
Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization.
Topics: Amino Acids; Anemia, Macrocytic; Contraceptives, Oral; Diet; DNA; Ethanol; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Glycine; Homocysteine; Humans; Malabsorption Syndromes; Methionine; Pharmacology; Serine; Toxins, Biological; Vitamin B 12 | 1970 |
Formation, functions and regulatory importance of S-adenosyl-L-methionine.
Topics: Adenosine; Adenosine Triphosphate; Alkanes; Alkenes; Alkynes; Amino Acids; Animals; Antineoplastic Agents; Binding Sites; Carbon Isotopes; Carboxylic Acids; Cyclopentanes; Escherichia coli; Homocysteine; Homoserine; Kinetics; Liver; Methionine; Methylation; Mice; Neoplasms, Experimental; Rats; Spleen; Transferases; Tritium; Yeasts | 1970 |
S-amino acid metabolism and its regulation in Escherichia coli and Salmonella typhimurium.
Topics: Amino Acids; Aspartic Acid; Chromosome Mapping; Chromosomes, Bacterial; Conjugation, Genetic; Cysteine; Escherichia coli; Feedback; Genes; Genes, Regulator; Homocysteine; Methionine; Methylation; Salmonella; Salmonella typhimurium; Serine; Sulfates; Transduction, Genetic | 1971 |
Roles of vitamin B 12 and folic acid in methionine synthesis.
Topics: Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Methyltransferases; S-Adenosylmethionine; Transferases; Vitamin B 12 | 1970 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
Betaine, metabolic by-product or vital methylating agent?
Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates | 1983 |
Biochemistry of sulfur-containing amino acids.
Topics: Adenosine; Amino Acid Metabolism, Inborn Errors; Animals; Cysteine; Deoxyadenosines; Homocysteine; Humans; Methionine; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; S-Adenosylmethionine; Structure-Activity Relationship; Sulfur; Sulfurtransferases; Thionucleosides; Thiosulfate Sulfurtransferase | 1983 |
Methionine dependence in cancer cells - a review.
Topics: Animals; Carbon-Sulfur Lyases; Cell Division; Cell Line; Cell Transformation, Neoplastic; Homocysteine; Humans; Methionine; Neoplasms; Neoplasms, Experimental | 1982 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deoxyuridine; Erythrocytes, Abnormal; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Homocysteine; Humans; Hypothyroidism; Lymphocyte Activation; Methionine; Pregnancy; Pregnancy Complications; Statistics as Topic; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
Is an elevated circulating maternal homocysteine concentration a risk factor for neural tube defects?
Topics: Biomarkers; Female; Homocysteine; Humans; Methionine; Methylation; Neural Tube Defects; Pregnancy; Risk Factors | 1995 |
Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds.
Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Homocysteine; Mammals; Methionine; Oxidation-Reduction; Oxygenases; Sulfoxides | 1995 |
Hyperhomocysteinaemia: a role in the accelerated atherogenesis of chronic renal failure?
Topics: Adult; Age Factors; Arteriosclerosis; Cystathionine beta-Synthase; Cysteine; Female; Folic Acid; Heterozygote; Homocysteine; Homocystinuria; Humans; Kidney Failure, Chronic; Male; Methionine; Methylation; Middle Aged; Renal Dialysis; Sex Factors | 1995 |
Folate status, women's health, pregnancy outcome, and cancer.
Topics: Adolescent; Adult; Animals; Arteriosclerosis; Female; Folic Acid Deficiency; Homocysteine; Humans; Infant; Maternal-Fetal Exchange; Methionine; Middle Aged; Neural Tube Defects; Papillomaviridae; Pregnancy; Rats; Tumor Virus Infections; Uterine Cervical Neoplasms; Women's Health | 1993 |
Hyperhomocysteinaemia: a newly recognized risk factor for vascular disease.
Topics: Arteriosclerosis; Betaine; Coronary Disease; Folic Acid; Heterozygote; Homocysteine; Homocystinuria; Homozygote; Humans; Methionine; Pyridoxine; Risk Factors; Vascular Diseases | 1994 |
Homocysteinemia: association of a metabolic disorder with vascular disease and thrombosis.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Blood Coagulation Factors; Blood Platelets; Child; Cystathionine beta-Synthase; Endothelium, Vascular; Fibrinolytic Agents; Folic Acid Deficiency; Homocysteine; Humans; Incidence; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Penicillamine; Risk Factors; Thrombosis; Vascular Diseases; Vitamin B 12; Vitamin B 6 Deficiency; Vitamins | 1993 |
Vitamins as homocysteine-lowering agents.
Topics: Homocysteine; Humans; Methionine; Vitamins | 1996 |
Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia.
Topics: Amino Acid Metabolism, Inborn Errors; Cystathionine beta-Synthase; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Phenotype; Prevalence; Risk Factors; Vascular Diseases | 1996 |
Homocysteinemia and vascular disease in end-stage renal disease.
Topics: Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Male; Methionine; Middle Aged; Pyridoxine; Thrombosis; Vitamin B 12 | 1996 |
Hyperhomocysteinemia. An emerging and important risk factor for thromboembolic and cardiovascular disease.
Topics: Cardiovascular Diseases; Homocysteine; Homocystine; Humans; Methionine; Risk Factors; Thromboembolism; Thrombosis; Vitamins | 1996 |
Folic acid in the prevention of birth defects.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Methionine; Neural Tube Defects; Preconception Care; Pregnancy; Prenatal Care | 1996 |
Disorders of homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Amino Acid Metabolism, Inborn Errors; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases | 1997 |
Assessment of homocysteine status.
Topics: Animals; Homocysteine; Humans; Methionine; Specimen Handling | 1997 |
Vitamin B-12 deficiency in the elderly: current dilemmas.
Topics: Acyl Coenzyme A; Aged; Aged, 80 and over; Female; Homocysteine; Humans; Male; Methionine; Methylmalonic Acid; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Hyperhomocysteinemia: detection, risk assessment, and treatment.
Topics: Animals; Homocysteine; Humans; Kidney Failure, Chronic; Methionine; Risk Factors; Vascular Diseases | 1997 |
[Folates and the neural tube. Review of the literature].
Topics: Animals; Europe; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Methionine; Methylation; Neural Crest; Neural Tube Defects; Preconception Care; Pregnancy; Prenatal Care; Prevalence; Risk Factors | 1997 |
[Hyperhomocysteinemia: a new marker of vascular risk: affected vascular areas, its role in the pathogenesis of arteriosclerosis and thrombosis and treatment].
Topics: Adult; Coronary Artery Disease; Coronary Thrombosis; Female; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Peripheral Vascular Diseases; Pregnancy; Thrombophlebitis; Vitamins | 1997 |
[Moderate hyperhomocysteinemia: physiopathology of the endothelial lesion and its clinical implications].
Topics: Amino Acid Metabolism, Inborn Errors; Avitaminosis; Cardiovascular Diseases; Cerebrovascular Disorders; Endothelium, Vascular; Homocysteine; Homocystinuria; Homozygote; Humans; Methionine; Myocardial Ischemia; Peripheral Vascular Diseases; Risk Factors; Thrombophlebitis; Vitamins | 1998 |
The metabolism of homocysteine: pathways and regulation.
Topics: Animals; Homocysteine; Humans; Hydrolysis; Methionine; Methylation; S-Adenosylmethionine | 1998 |
Remethylation defects: guidelines for clinical diagnosis and treatment.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Betaine; Child, Preschool; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Infant; Infant, Newborn; Metabolism, Inborn Errors; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Oxidoreductases Acting on CH-NH Group Donors; Practice Guidelines as Topic; Vitamin B 12 | 1998 |
Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders.
Topics: Central Nervous System Diseases; Citrates; Demyelinating Diseases; Folic Acid; Homocysteine; Humans; Mental Disorders; Methionine; Methylmalonic Acid; Vitamin B 12 | 1998 |
Neural tube defects, vitamins and homocysteine.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Rats; Spinal Dysraphism | 1998 |
Hyperhomocysteinemia and venous thrombosis: a meta-analysis.
Topics: Adult; Case-Control Studies; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Odds Ratio; Risk Factors; Venous Thrombosis | 1998 |
Hyperhomocysteinemia, atherosclerosis and thrombosis.
Topics: Adult; Aged; Animals; Arteriosclerosis; Avitaminosis; Case-Control Studies; Clinical Trials as Topic; Cohort Studies; Cross-Sectional Studies; Cystathionine beta-Synthase; Female; Folic Acid; Gene Frequency; Homocysteine; Homocystinuria; Hormone Replacement Therapy; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Muscle, Smooth, Vascular; Oxidoreductases Acting on CH-NH Group Donors; Prevalence; Primates; Prospective Studies; Pyridoxine; Risk Factors; Smoking; Tamoxifen; Thrombophilia; Thrombosis; Vitamin B 12 | 1999 |
Homocysteine: an emerging age-related cardiovascular risk factor.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Menopause; Methionine; Middle Aged; Prevalence; Primary Health Care; Risk Factors | 1999 |
[Hyperhomocysteinemia, a risk factor for atherosclerosis: causes and effects].
Topics: Age Factors; Arterial Occlusive Diseases; Arteriosclerosis; Cerebrovascular Disorders; Coronary Disease; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipid Metabolism; Lipoproteins; Male; Meta-Analysis as Topic; Methionine; Middle Aged; Peripheral Vascular Diseases; Prospective Studies; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors | 1999 |
B vitamins, homocysteine, and neurocognitive function in the elderly.
Topics: Aging; Animals; Brain; Cognition Disorders; Homocysteine; Humans; Methionine; Tetrahydrofolates; Vitamin B Deficiency | 2000 |
Homocysteine and endothelial dysfunction: a link with cardiovascular disease.
Topics: Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Methionine; Reactive Oxygen Species | 2000 |
Homocysteine and ischaemic heart disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Cohort Studies; Comorbidity; Cystathionine beta-Synthase; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Ischemia; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Retrospective Studies | 1999 |
Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care.
Topics: Aged; Arteriosclerosis; Canada; Coronary Disease; Dietary Supplements; Disease Susceptibility; Fasting; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine; Preventive Medicine; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12 | 2000 |
Homocysteine: a history in progress.
Topics: History, 19th Century; History, 20th Century; Homocysteine; Homocystinuria; Humans; Insulin; Methionine; Neural Tube Defects; North America; Research; S-Adenosylmethionine; Workforce | 2000 |
Pathways and regulation of homocysteine metabolism in mammals.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Homocysteine; Isoenzymes; Kinetics; Mammals; Methionine; Methionine Adenosyltransferase; Organ Specificity; Oxidation-Reduction; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tetrahydrofolates | 2000 |
Biological and environmental determinants of plasma homocysteine.
Topics: Adult; Aged; Aging; Alcohol Drinking; Child; Cystathionine beta-Synthase; Diagnosis-Related Groups; Dietary Proteins; Endocrine System Diseases; Female; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Inflammation; Intestinal Diseases; Life Style; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasms; Niacin; Nitrous Oxide; Norway; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Renal Insufficiency; Smoking; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2000 |
Homocysteine and renal disease.
Topics: Adult; Arteriosclerosis; Cardiovascular Diseases; Case-Control Studies; Child; Endothelium, Vascular; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Life Tables; Male; Methionine; Peritoneal Dialysis; Prospective Studies; Pyridoxine; Renal Dialysis; Survival Analysis; Thrombophilia; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2000 |
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.
Topics: Adolescent; Adult; Aged; Australia; Child; Child, Preschool; Cohort Studies; Cystine; Drug Resistance; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Infant; Ireland; Male; Methionine; Middle Aged; Netherlands; Pyridoxine; Risk; Risk Factors; Thrombophilia; Vascular Diseases; Vitamin B 12 | 2000 |
Non-dopaminergic drug treatment of Parkinson's disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Body Weight; Cholinergic Antagonists; Homocysteine; Humans; Levodopa; Methionine; N-Methylaspartate; Parkinson Disease; Piperidines; Serotonin Receptor Agonists | 2001 |
Approaches towards understanding methionine biosynthesis in higher plants.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Carbon-Oxygen Lyases; Cystathionine beta-Synthase; Homocysteine; Methionine; Molecular Biology; Plants; Plants, Genetically Modified | 2001 |
[From gene to disease; from homocysteine to hyperhomocysteinemia].
Topics: Cystathionine beta-Synthase; Folic Acid; Heterozygote; Homocysteine; Homocystinuria; Homozygote; Humans; Hyperhomocysteinemia; Methionine; Mutation; Risk Factors; Vascular Diseases | 2001 |
Roles of homocysteine in cell metabolism: old and new functions.
Topics: Cardiovascular Diseases; Cell Physiological Phenomena; Female; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Nervous System Malformations; Pregnancy; Pregnancy Complications; RNA, Transfer, Amino Acyl; S-Adenosylmethionine | 2001 |
Homocysteine-lowering treatment: an overview.
Topics: Animals; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Vitamin B Deficiency; Vitamins | 2001 |
Vascular dysfunction in hyperhomocyst(e)inemia. Implications for atherothrombotic disease.
Topics: Endothelium, Vascular; Free Radicals; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Models, Biological; Models, Chemical; Oxidative Stress; Vascular Diseases; Venous Thrombosis | 2001 |
Protein N-homocysteinylation: implications for atherosclerosis.
Topics: Arteriosclerosis; Cardiovascular Diseases; Endothelium, Vascular; Homocysteine; Humans; Methionine; Models, Biological; Proteins | 2001 |
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
[Homocystinuria in adulthood].
Topics: Adult; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; Methionine | 2001 |
Manipulating the sulfur amino acid content of the early diet and its implications for long-term health.
Topics: Amino Acids, Sulfur; Animals; Dietary Proteins; Embryonic and Fetal Development; Female; Gene Expression Regulation, Developmental; Homocysteine; Humans; Methionine; Nutritional Requirements; Pregnancy; Prenatal Exposure Delayed Effects; Protein Deficiency; Rats | 2002 |
Why are homocysteine levels increased in kidney failure? A metabolic approach.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Betaine-Homocysteine S-Methyltransferase; Disulfides; Homocysteine; Humans; Kidney; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Renal Insufficiency | 2002 |
Postmethionine-load homocysteine determination for the diagnosis hyperhomocysteinaemia and efficacy of homocysteine lowering treatment regimens.
Topics: Cardiovascular Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Randomized Controlled Trials as Topic; Risk Factors; Treatment Outcome | 2002 |
Hormones and homocysteine.
Topics: Diabetic Angiopathies; Homocysteine; Hormones; Humans; Hyperhomocysteinemia; Hyperlipidemias; Methionine; Vascular Diseases | 2002 |
Methods for measuring sulfur amino acid metabolism.
Topics: Amino Acids, Sulfur; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kinetics; Methionine; Methylation; Models, Biological; Radioisotope Dilution Technique; Vitamin B 12 | 2002 |
In vivo stable isotope measurements of methyl metabolism: applications in pathophysiology and interventions.
Topics: Deuterium Oxide; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infusions, Intravenous; Kidney Failure, Chronic; Methionine; Methylation; Serine; Tomography, Emission-Computed; Tritium | 2002 |
Pharmacotherapy of hyperhomocysteinaemia in patients with thrombophilia.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Pyridoxine; Renal Insufficiency; Thrombophilia; Vitamin B 12; Vitamins | 2002 |
Homocysteine, folate deprivation and Alzheimer neuropathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Nerve Degeneration | 2002 |
The methionine-homocysteine cycle and its effects on cognitive diseases.
Topics: Alzheimer Disease; Cardiovascular Diseases; Cognition Disorders; Dementia, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Memory Disorders; Methionine; Methionine Adenosyltransferase; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2003 |
Hyperhomocysteinemia, vascular function and atherosclerosis: effects of vitamins.
Topics: Arteriosclerosis; Avitaminosis; Coronary Disease; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Kidney Failure, Chronic; Methionine; Risk Factors; Thrombosis; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamins | 2002 |
Methyl group deficiency and guanidino production in uremia.
Topics: Animals; Arginine; Free Radicals; Guanidines; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Liver; Methionine; Mitochondria; Models, Biological; Models, Chemical; Oxygen; Succinates; Time Factors; Transaminases; Uremia | 2003 |
[Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data].
Topics: Animals; Arteriosclerosis; Biomarkers; Cystathionine beta-Synthase; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Nitric Oxide; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Rats; Risk Factors; S-Adenosylmethionine; Signal Transduction; Thrombophilia; Vascular Diseases; Vasodilation; Vitamin B 6 Deficiency | 2003 |
[BIOSYNTHESIS OF METHYL GROUP OF METHIONINE].
Topics: Alkylation; Amino Acids; Cysteine; Folic Acid; Homocysteine; Metabolism; Methionine; Research; Vitamin B 12 | 1964 |
AMINOACIDURIA.
Topics: Amino Acid Metabolism, Inborn Errors; Biological Transport; Cystinuria; Histidine; Homocysteine; Humans; Hydroxyproline; Kidney; Methionine; Proline; Renal Aminoacidurias | 1965 |
Methionine dependency and cancer treatment.
Topics: Animals; Antineoplastic Agents, Alkylating; Carbon-Sulfur Lyases; Clinical Trials, Phase I as Topic; Homocysteine; Humans; Methionine; Neoplasms | 2003 |
Homocysteine remethylation and trans-sulfuration.
Topics: Animals; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Sulfur | 2004 |
Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle.
Topics: Avitaminosis; Cardiovascular Diseases; Creatinine; Folic Acid; Homocysteine; Humans; Incidence; Kidney Diseases; Life Style; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Physiological Phenomena; Polymorphism, Genetic; Pyridoxal; Riboflavin; Vitamin B 12 | 2004 |
The impact of metabolism on DNA methylation.
Topics: Alzheimer Disease; Animals; Arteriosclerosis; DNA Methylation; Folic Acid; Gene Expression Regulation; Glycine N-Methyltransferase; Homocysteine; Humans; Methionine; Methyltransferases; Models, Biological; S-Adenosylmethionine | 2005 |
The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence.
Topics: Carotenoids; Cell Transformation, Neoplastic; Cysteine; Diet; Female; Folic Acid; Homocysteine; Humans; Methionine; Nutritional Physiological Phenomena; Uterine Cervical Neoplasms; Vitamins | 2005 |
Influence of impaired liver methionine metabolism on the development of vascular disease and inflammation.
Topics: Animals; Homocysteine; Humans; Inflammation; Liver; Liver Diseases; Methionine; Vascular Diseases | 2005 |
Homocysteine: overview of biochemistry, molecular biology, and role in disease processes.
Topics: Animals; Disease Progression; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Oxidation-Reduction | 2005 |
Mechanisms of the atherogenic effects of elevated homocysteine in experimental models.
Topics: Animals; Arteriosclerosis; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Hyperhomocysteinemia; Methionine; Mice; Nitric Oxide; Oxidative Stress; Risk Factors | 2005 |
Homocysteine and methionine metabolism in renal failure.
Topics: Biomarkers; Glomerular Filtration Rate; Homocysteine; Humans; Kidney Failure, Chronic; Methionine; Methylation | 2005 |
The significance of folic acid for epilepsy patients.
Topics: Anticonvulsants; Epilepsy; Female; Folic Acid; History, 20th Century; Homocysteine; Humans; Male; Methionine; Models, Biological; Neural Tube Defects; Pregnancy; Vascular Diseases | 2005 |
Mechanisms of homocysteine-induced atherothrombosis.
Topics: Animals; Apolipoproteins E; Apoptosis; Arginine; Atherosclerosis; Coronary Thrombosis; Cysteine; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Models, Biological; Nitric Oxide; Oxidative Stress; Oxygen; Phenotype; Signal Transduction | 2005 |
Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; DNA; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Mutation | 2006 |
Hyperhomocysteinemia and response of methionine cycle intermediates to vitamin treatment in renal patients.
Topics: Animals; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Methionine; Methylation; Vitamins | 2005 |
Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease.
Topics: Cytokines; Hepatocytes; Homocysteine; Humans; Lipopolysaccharides; Liver; Liver Diseases, Alcoholic; Methionine; Proteasome Endopeptidase Complex | 2005 |
Disruption of methyl group metabolism by ethanol.
Topics: Animals; Central Nervous System Depressants; Ethanol; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Liver; Methionine; Rats; Swine; Swine, Miniature | 2005 |
The use of betaine in the treatment of elevated homocysteine.
Topics: Amino Acid Metabolism, Inborn Errors; Betaine; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation | 2006 |
Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Biological Transport; Bone Marrow; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Myelin Sheath; Nerve Tissue; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
The sulfur-containing amino acids: an overview.
Topics: Allosteric Regulation; Amino Acids, Sulfur; Animals; Cysteine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Proteins; S-Adenosylmethionine; Taurine | 2006 |
The nutritional relationship linking sulfur to nitrogen in living organisms.
Topics: Aging; Animals; Body Composition; Diet; Homeostasis; Homocysteine; Humans; Methionine; Methylation; Nitrates; Nitrogen; Nutritional Physiological Phenomena; Oxidation-Reduction; Plants, Edible; Prealbumin; Protein Deficiency; Stress, Physiological; Sulfates; Sulfur | 2006 |
Adequate range for sulfur-containing amino acids and biomarkers for their excess: lessons from enteral and parenteral nutrition.
Topics: Amino Acids, Sulfur; Animals; Biomarkers; Cysteine; Dietary Supplements; Enteral Nutrition; Glutathione; Homocysteine; Humans; Methionine; Nutritional Requirements; Parenteral Nutrition; Sulfur; Taurine | 2006 |
Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet.
Topics: Amino Acids, Sulfur; Animals; Choline; Diet; DNA Methylation; Drug Interactions; Endocrine System; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Methionine; Methylation; Nutritional Requirements; Pregnancy; Proteins; S-Adenosylmethionine | 2006 |
Toxicity of methionine in humans.
Topics: Cystathionine; Diet; Endothelium, Vascular; Homocysteine; Humans; Infant; Infant Nutritional Physiological Phenomena; Methionine; Nutritional Physiological Phenomena; Nutritional Requirements | 2006 |
Neural tube defects and folate: case far from closed.
Topics: Animals; Central Nervous System; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects | 2006 |
Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Homocysteine; Hormones; Humans; Liver; Methionine; Promoter Regions, Genetic; Protein Folding; Structure-Activity Relationship | 2006 |
Emerging aspects of gut sulfur amino acid metabolism.
Topics: Amino Acids, Sulfur; Biological Availability; Cysteine; DNA Methylation; Gastrointestinal Diseases; Homocysteine; Humans; Intestinal Absorption; Intestinal Mucosa; Methionine; Nutritional Physiological Phenomena; Oxidation-Reduction; S-Adenosylmethionine | 2007 |
[Risk factors for cardiovascular diseases: what is the role for homocysteine?].
Topics: Cardiovascular Diseases; Folic Acid; Follow-Up Studies; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Vitamin B 12; Vitamin B 6 | 2007 |
[Homocysteine metabolism].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltransferase; Cardiovascular Diseases; Deuterium; Gas Chromatography-Mass Spectrometry; Gout; Homocysteine; Humans; Hyperhomocysteinemia; Isotope Labeling; Methionine; Oxidation-Reduction; Risk Factors; Serum Albumin; Vitamin B 12 | 2007 |
[Measurement of methylmalonic acid, homocysteine and methionine in cobalamin and folate deficiencies and homocysteinuria].
Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Diagnosis, Differential; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Infant; Infant, Newborn; Methionine; Methylmalonic Acid; Vitamin B 12 Deficiency | 2008 |
Dehydroascorbic acid as an anti-cancer agent.
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Dehydroascorbic Acid; Homocysteine; Humans; Methionine; Mice; Neoplasms | 2008 |
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
Topics: Antioxidants; Biopterins; Depression; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Neurotransmitter Agents; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2008 |
Alcoholic liver disease and methionine metabolism.
Topics: Alcohol Drinking; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Ethanol; Homocysteine; Humans; Liver; Liver Diseases, Alcoholic; Methionine; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine | 2009 |
Inherited disorders in the conversion of methionine to homocysteine.
Topics: Adenosylhomocysteinase; Amino Acid Metabolism, Inborn Errors; Glycine N-Methyltransferase; Health Planning Guidelines; Homocysteine; Humans; Methionine; Methionine Adenosyltransferase; Models, Biological | 2009 |
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur.
Topics: Animals; Cysteine; Homocysteine; Humans; Metabolic Networks and Pathways; Methionine; Models, Biological; Rats; Sulfur; Sulfur Compounds; Taurine | 2011 |
Cobalamin C defect: natural history, pathophysiology, and treatment.
Topics: Age of Onset; Homocysteine; Humans; Methionine; Methylmalonic Acid; Models, Biological; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Mechanisms of cardiovascular remodeling in hyperhomocysteinemia.
Topics: Animals; Cardiovascular Diseases; Cardiovascular System; Homocysteine; Humans; Hyperhomocysteinemia; Matrix Metalloproteinases; Methionine; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species | 2011 |
Chemical biology of homocysteine thiolactone and related metabolites.
Topics: Amyloid; Animals; Brain Diseases; Cardiovascular Diseases; Dipeptides; Homocysteine; Humans; Methionine; Methionine-tRNA Ligase; Mice; Protein Biosynthesis; Proteins; Proteolysis | 2011 |
Hypohomocysteinemia: a potentially treatable cause of peripheral neuropathology?
Topics: Aged; Female; Homocysteine; Humans; Metabolic Networks and Pathways; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Peripheral Nervous System Diseases | 2012 |
Effects of decreased availability of sulfur amino acids in severe childhood undernutrition.
Topics: Amino Acids, Sulfur; Biological Availability; Child; Child Nutrition Disorders; Child, Preschool; Edema; Glutathione; Homocysteine; Humans; Methionine; Methylation; Protein-Energy Malnutrition | 2012 |
Methionine, homocysteine, one carbon metabolism and fetal growth.
Topics: Adult; Animals; Carbon; Dietary Proteins; Energy Intake; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Methionine; Pregnancy; Rats; Vitamin B 12; Vitamins | 2012 |
Role of heat-shock proteins and cobalamine in maintaining methionine synthase activity.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Heat-Shock Proteins; Homocysteine; Humans; Kinetics; Metabolic Networks and Pathways; Methionine; Methylation; Plaque, Atherosclerotic; Vitamin B 12 | 2012 |
The perioperative use of nitrous oxide: renaissance of an old gas or funeral of an ancient relict?
Topics: Analgesics; Anesthesiology; Anesthetics, Inhalation; Anti-Anxiety Agents; Homocysteine; Humans; Immune System; Intraoperative Awareness; Methionine; Nitrous Oxide; Occupational Exposure; Perioperative Care | 2013 |
Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology.
Topics: Cardiovascular Diseases; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Oxidation-Reduction; Randomized Controlled Trials as Topic; Vitamin B Complex; Vitamin B Deficiency; Vitamins | 2013 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine | 2013 |
Vitamin B(12) metabolism during pregnancy and in embryonic mouse models.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acyl Coenzyme A; Animals; Disease Models, Animal; Embryonic Development; Female; Homocysteine; Humans; Methionine; Methylmalonyl-CoA Mutase; Mice; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review.
Topics: Animals; Epigenesis, Genetic; Fatigue Syndrome, Chronic; Folic Acid; Folic Acid Deficiency; Gene-Environment Interaction; Homocysteine; Humans; Methionine; Neural Tube Defects; Progeria | 2014 |
Lifetime requirement of the methionine cycle for neuronal development and maintenance.
Topics: Developmental Disabilities; Female; Folic Acid; Homocysteine; Humans; Methionine; Pregnancy; Prenatal Care; S-Adenosylmethionine; Vitamin B 12; Vitamin B Complex | 2014 |
Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
Topics: Aldehyde Dehydrogenase; Carbon; Folic Acid; Genome-Wide Association Study; Genotype; Homocysteine; Humans; Methionine; Oxidoreductases Acting on CH-NH Group Donors; Stroke; Vitamin B 12 | 2014 |
Homocysteine and DNA methylation: a review of animal and human literature.
Topics: Animals; Case-Control Studies; Diet; Dietary Supplements; DNA Methylation; Female; Folic Acid; Gene Knockout Techniques; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Models, Animal; Vitamin B Complex; Vitamin B Deficiency | 2014 |
Homocysteine, iron and cardiovascular disease: a hypothesis.
Topics: Biomarkers; Cardiovascular Diseases; Cystathionine; Dietary Supplements; Folic Acid; Free Radicals; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Lipoproteins, LDL; Methionine; Risk Factors; S-Adenosylhomocysteine; Vitamin B Complex | 2015 |
Methylation reactions, the redox balance and atherothrombosis: the search for a link with hydrogen sulfide.
Topics: Animals; Aspirin; Atherosclerosis; Folic Acid; Gasotransmitters; Homocysteine; Humans; Hydrogen Sulfide; Methionine; Methylation; Oxidation-Reduction; Thrombosis | 2015 |
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders.
Topics: Consensus; Homocysteine; Humans; Infant, Newborn; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Methylation; Neonatal Screening; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency.
Topics: Betaine; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; Methionine; Pyridoxine | 2017 |
Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency.
Topics: Animals; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Proto-Oncogene Proteins c-cbl; Vitamin B 12 | 2017 |
Cystathionine β-synthase deficiency: Of mice and men.
Topics: Animals; Animals, Newborn; Cystathionine beta-Synthase; Disease Models, Animal; Genotype; Homocysteine; Homocystinuria; Humans; Male; Metabolism, Inborn Errors; Methionine; Mice; Mutation; Phenotype; Pyridoxine | 2017 |
Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis.
Topics: Betaine-Homocysteine S-Methyltransferase; Biomarkers; Body Composition; Body Mass Index; Cystathionine beta-Synthase; Diet, Protein-Restricted; Dietary Proteins; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Methionine; S-Adenosylmethionine | 2017 |
Hyperhomocysteinemia and cardiovascular disease in animal model.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Risk Factors | 2018 |
Inborn Errors of Metabolism with Cognitive Impairment: Metabolism Defects of Phenylalanine, Homocysteine and Methionine, Purine and Pyrimidine, and Creatine.
Topics: Cognitive Dysfunction; Creatine; Diagnosis, Differential; Homocysteine; Humans; Metabolism, Inborn Errors; Methionine; Phenylalanine; Purines; Pyrimidines | 2018 |
Medicines associated with folate-homocysteine-methionine pathway disruption.
Topics: Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Pregnancy; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Vitamin B 12 Deficiency | 2019 |
The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art.
Topics: Atherosclerosis; Cardiovascular Diseases; Endothelial Cells; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Methionine; Nitric Oxide; Reactive Oxygen Species; S-Adenosylhomocysteine | 2019 |
Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism.
Topics: Animals; Enzymes; Homocysteine; Humans; Mammals; Metabolic Networks and Pathways; Methionine; Protein Binding | 2020 |
Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles.
Topics: Cell Line, Tumor; Epigenesis, Genetic; Folic Acid; Homocysteine; Humans; Methionine; Neoplasms; Neoplastic Stem Cells; Vitamin B 12 | 2020 |
Gut microbiota and the periodontal disease: role of hyperhomocysteinemia.
Topics: Dysbiosis; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Periodontitis; Probiotics | 2021 |
Metabolism of Sulfur-Containing Amino Acids: How the Body Copes with Excess Methionine, Cysteine, and Sulfide.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cystathionine beta-Synthase; Cysteine; Glycine N-Methyltransferase; Homocysteine; Humans; Hydrogen Sulfide; Liver; Methionine; S-Adenosylmethionine; Serine; Sulfides; Sulfur; Thiosulfates | 2020 |
Lessons Learned from Inherited Metabolic Disorders of Sulfur-Containing Amino Acids Metabolism.
Topics: Amino Acids, Sulfur; Animals; Brain Diseases; Cysteine; Glutathione; Homocysteine; Homocystinuria; Humans; Hydrogen Sulfide; Liver; Metabolic Diseases; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Methylation; S-Adenosylmethionine; Sulfites; Sulfur; Sulfur Compounds | 2020 |
Methionine Nutrition and Metabolism: Insights from Animal Studies to Inform Human Nutrition.
Topics: Animals; Betaine; Choline; Creatine; Cysteine; Diet; Folic Acid; Glutathione; Homocysteine; Humans; Methionine; Methylation; Models, Animal; Nutritional Requirements; Nutritional Status; Phosphatidylcholines; S-Adenosylmethionine; Sulfur | 2020 |
Metabolic Consequences of Supplemented Methionine in a Clinical Context.
Topics: Animals; Body Fluid Compartments; Cardiovascular Diseases; Dietary Supplements; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Proteins; Vitamin B Complex; Vitamin B Deficiency | 2020 |
Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks.
Topics: Carbon Cycle; Cardiovascular Diseases; Diabetes Mellitus; Epigenesis, Genetic; Female; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vascular Diseases; Vitamin B 12 | 2021 |
Hyperhomocysteinemia and cardiovascular diseases.
Topics: Cardiovascular Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Risk Factors | 2022 |
COVID-19 and One-Carbon Metabolism.
Topics: Carbon; COVID-19; Folic Acid; Homocysteine; Humans; Methionine; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Vitamin B 12 | 2022 |
Deciphering the Role of S-adenosyl Homocysteine Nucleosidase in Quorum Sensing Mediated Biofilm Formation.
Topics: Bacteria; Biofilms; Homocysteine; Humans; Methionine; N-Glycosyl Hydrolases; Quorum Sensing | 2022 |
Betaine consumption as a new clinical approach to treatment and prophylaxis of folate-related pathologies.
Topics: Amino Acids; Betaine; Betaine-Homocysteine S-Methyltransferase; Folic Acid; Homocysteine; Humans; Methionine | 2023 |
Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Topics: Arginine; Cysteine; Folic Acid; Homocysteine; Humans; Metabolomics; Methionine; Nitric Oxide; Racemethionine; Vitamins | 2023 |
Folate and retinal vascular diseases.
Topics: Diabetic Retinopathy; Endothelial Cells; Folic Acid; Glucose; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2023 |
92 trial(s) available for homocysteine and methionine
| Article | Year |
|---|---|
Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Arterial Occlusive Diseases; Biomarkers; Blood Pressure; Cholesterol; Endothelium, Vascular; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methionine; Middle Aged; Pyridoxine; Smoking; Thrombomodulin; Time Factors; Tissue Plasminogen Activator; von Willebrand Factor | 1995 |
Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia.
Topics: Erythrocyte Membrane; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uremia | 1997 |
Treatment of hyperhomocysteinemia in renal transplant recipients. A randomized, placebo-controlled trial.
Topics: Drug Therapy, Combination; Factor Analysis, Statistical; Folic Acid; Homocysteine; Humans; Kidney Transplantation; Methionine; Pyridoxine; Risk Factors; Vitamin B 12 | 1997 |
Acute hyperhomocysteinaemia and endothelial dysfunction.
Topics: Adult; Arteriosclerosis; Endothelium, Vascular; Homocysteine; Humans; Methionine; Nitric Oxide; Risk Factors | 1998 |
Homocysteine and endothelial vascular function.
Topics: Adult; Arteriosclerosis; Endothelium, Vascular; Homocysteine; Humans; Methionine; Thiobarbituric Acid Reactive Substances; Vasoconstriction | 1998 |
Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction.
Topics: Dietary Supplements; Female; Fetal Growth Retardation; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Medical History Taking; Methionine; Pre-Eclampsia; Pregnancy; Pyridoxine; Statistics, Nonparametric | 1998 |
Correlation between total homocysteine and cyclosporine concentrations in cardiac transplant recipients.
Topics: Adult; Aged; Cyclosporine; Female; Folic Acid; Heart Transplantation; Homocysteine; Humans; Immunosuppressive Agents; Kidney Glomerulus; Linear Models; Male; Metabolic Diseases; Methionine; Middle Aged; Postoperative Complications; Vitamin B 12 | 1998 |
Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy.
Topics: Adult; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Oxidative Stress; Time Factors | 1999 |
Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients.
Topics: Adult; Betaine; Fasting; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methionine; Methylation; Middle Aged; Renal Dialysis; Time Factors; Treatment Outcome | 1999 |
Folate nutriture alters choline status of women and men fed low choline diets.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Choline; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lipids; Male; Methionine; Methylation; Middle Aged; Nutritional Physiological Phenomena; Nutritional Status; Phosphatidylcholines; Reference Values; S-Adenosylmethionine | 1999 |
Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins.
Topics: Acute Disease; Adult; Antioxidants; Arginine; Ascorbic Acid; Blood Coagulation; Blood Viscosity; Cardiovascular Diseases; Cross-Over Studies; Endothelium, Vascular; Female; Hemodynamics; Homocysteine; Humans; Male; Methionine; Platelet Aggregation; Risk Factors; Single-Blind Method; Vitamin E | 1999 |
Variability of fasting and post-methionine plasma homocysteine levels in normo- and hyperhomocysteinaemic individuals.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Analysis of Variance; Fasting; Female; Folic Acid; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases; Statistics, Nonparametric | 1999 |
Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation.
Topics: Acetylcholine; Adult; Chromatography, High Pressure Liquid; Dietary Supplements; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Homocysteine; Humans; Lipid Peroxidation; Male; Methionine; Nitric Oxide; Nitroprusside; Plethysmography; Thiobarbituric Acid Reactive Substances | 1999 |
Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects.
Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Beverages; Brachial Artery; Dietary Proteins; Endothelium, Vascular; Female; Fruit; Homocysteine; Humans; Male; Methionine; Middle Aged; Vasodilation | 1999 |
Peroxidation indices and total antioxidant capacity in plasma during hyperhomocysteinemia induced by methionine oral loading.
Topics: Aged; Antioxidants; Blood Proteins; Female; Homocysteine; Humans; Lipid Peroxidation; Male; Malondialdehyde; Methionine; Middle Aged | 2000 |
Low-dose folic acid supplementation does not influence plasma methionine concentrations in young non-pregnant women.
Topics: Adolescent; Adult; Contraceptives, Oral; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Vitamin B 12 | 1999 |
Oxidative stress and an altered methionine metabolism in alcoholism.
Topics: Adult; Aged; Alcoholism; Chlormethiazole; Chromatography, High Pressure Liquid; Chronic Disease; Ethanol; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypnotics and Sedatives; Lipid Peroxidation; Male; Malondialdehyde; Methionine; Middle Aged; Oxidative Stress | 2000 |
Fluctuations in dietary methionine intake do not alter plasma homocysteine concentration in healthy men.
Topics: Adult; Body Mass Index; Diet; Diet Records; Energy Intake; Homocysteine; Humans; Male; Methionine; Vitamin B 12 | 2000 |
Impairment of cerebrovascular reactivity by methionine-induced hyperhomocysteinemia and amelioration by quinapril treatment.
Topics: Adult; Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Endothelium, Vascular; Female; Homocysteine; Humans; Isoquinolines; Male; Methionine; Middle Aged; Quinapril; Stroke; Tetrahydroisoquinolines; Ultrasonography, Doppler, Transcranial | 2000 |
Acute methionine loading does not alter arterial stiffness in humans.
Topics: Adult; Analysis of Variance; Antioxidants; Arteriosclerosis; Ascorbic Acid; Blood Pressure; Double-Blind Method; Drug Combinations; Heart Rate; Hemodynamics; Homocysteine; Humans; Male; Methionine; Vascular Resistance | 2001 |
Evidence against oxidative stress as mechanism of endothelial dysfunction in methionine loading model.
Topics: Adolescent; Adult; Aged; Brachial Artery; Cross-Over Studies; Endothelium, Vascular; Homocysteine; Humans; Lipid Peroxidation; Male; Methionine; Middle Aged; Nitrates; Oxidative Stress; Platelet Aggregation; Prospective Studies; Signal Transduction; Thiobarbituric Acid Reactive Substances | 2001 |
The effects of oral methionine and homocysteine on endothelial function.
Topics: Administration, Oral; Adult; Area Under Curve; Brachial Artery; Cross-Over Studies; Endothelium, Vascular; Female; Forearm; Homocysteine; Humans; Male; Methionine; Plethysmography; Regional Blood Flow | 2001 |
Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne.
Topics: Acne Vulgaris; Adult; Female; Homocysteine; Humans; Isotretinoin; Liver Function Tests; Male; Methionine; Treatment Outcome | 2001 |
Measurement of intracellular sulfur amino acid metabolism in humans.
Topics: Adult; Carbon Isotopes; Cystathionine; Energy Metabolism; Female; Homocysteine; Humans; Male; Methionine; Tritium | 2001 |
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia.
Topics: Acetylcholine; Administration, Oral; Adult; Area Under Curve; Ascorbic Acid; Cross-Over Studies; Endothelium, Vascular; Forearm; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intra-Arterial; Male; Methionine; Oxidative Stress; Plethysmography; Regional Blood Flow; Single-Blind Method; Vasodilation | 2001 |
Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects.
Topics: Administration, Oral; Adult; Brachial Artery; Cystathionine; Cysteine; Endothelium, Vascular; Female; Homocysteine; Humans; Male; Methionine; Oxidation-Reduction; Proteins; Time Factors; Vasodilation | 2001 |
Pyridoxine improves endothelial function in cardiac transplant recipients.
Topics: Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Follow-Up Studies; Heart Transplantation; Homocysteine; Humans; Male; Methionine; Middle Aged; Pyridoxine | 2001 |
Acute hyperhomocysteinaemia affects pulse pressure but not microvascular vasodilator function.
Topics: Acetylcholine; Administration, Oral; Adult; Blood Pressure; Blood Vessels; Cross-Over Studies; Double-Blind Method; Heart Rate; Homocysteine; Humans; Laser-Doppler Flowmetry; Male; Methionine; Nitroprusside; Pressure; Pulse; Skin; Vasodilation; Vasodilator Agents | 2001 |
Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviral therapy.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Antiretroviral Therapy, Highly Active; Biomarkers; Cystathionine; Cysteine; Fasting; Female; Folic Acid; HIV Infections; HIV-1; Homocysteine; Humans; Male; Methionine; Methylmalonic Acid; Middle Aged; Multivariate Analysis; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Sarcosine; Vitamin B 6 | 2001 |
Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics.
Topics: Adult; Amino Acids; Diet; Folic Acid Deficiency; Homocysteine; Humans; Leucine; Male; Methionine; Methylation; Nutritional Physiological Phenomena; Nutritional Status; Polymorphism, Genetic; Serine; Vitamin B 6 Deficiency | 2001 |
Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Osmolar Concentration; Renal Dialysis; Vitamin B 12; Vitamin B 6 | 2002 |
Thrombin formation in platelet-rich plasma after oral methionine loading: preliminary report.
Topics: Administration, Oral; Adult; Blood Platelets; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Kinetics; Male; Methionine; Middle Aged; Platelet Transfusion; Thrombin | 2002 |
Effect of dexrazoxane on homocysteine-induced endothelial dysfunction in normal subjects.
Topics: Adult; Antioxidants; Blood Flow Velocity; Brachial Artery; Cardiovascular Agents; Chelating Agents; Cross-Over Studies; Endothelium, Vascular; Female; Homocysteine; Humans; Iron; Male; Methionine; Oxidative Stress; Razoxane | 2002 |
The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs.
Topics: Adult; Anticonvulsants; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epilepsy; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Methionine; Middle Aged; Pyridoxic Acid; Riboflavin; Selectins; Vascular Cell Adhesion Molecule-1; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2002 |
Effect of protein and methionine intakes on plasma homocysteine concentrations: a 6-mo randomized controlled trial in overweight subjects.
Topics: Adolescent; Adult; Analysis of Variance; Body Weight; Diet; Diet, Protein-Restricted; Dietary Proteins; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Obesity; Vitamin B 12 | 2002 |
Effects of acute hyperhomocysteinemia on the neurovascular coupling mechanism in healthy young adults.
Topics: Acute Disease; Adult; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cross-Over Studies; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Photic Stimulation; Posterior Cerebral Artery; Reference Values; Systole; Ultrasonography, Doppler, Transcranial | 2003 |
Regulation of sulfur amino acid metabolism in men in response to changes in sulfur amino acid intakes.
Topics: Adult; Amino Acids, Sulfur; Carbon Isotopes; Cross-Over Studies; Cysteine; Deuterium; Diet; Dietary Proteins; Homocysteine; Humans; Kinetics; Male; Methionine; Methylation; Nutritional Requirements | 2003 |
N-Acetylcysteine improves the disturbed thiol redox balance after methionine loading.
Topics: Acetylcysteine; Adult; Antioxidants; Cross-Over Studies; Cysteine; Female; Homocysteine; Humans; Lipid Peroxidation; Male; Methionine; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Sulfhydryl Compounds | 2003 |
Fasting and post-methionine loading concentrations of homocysteine, vitamin B2, and vitamin B6 in patients on antiepileptic drugs.
Topics: Adult; Anticonvulsants; Fasting; Female; Homocysteine; Humans; Male; Methionine; Riboflavin; Vitamin B 6 | 2003 |
Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.
Topics: Adult; Age Factors; Aged; Arginine; Arteriosclerosis; Brachial Artery; Endothelium, Vascular; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Peripheral Vascular Diseases; Regional Blood Flow; Regression Analysis; Vasodilation | 2003 |
A 2-step strategy to reduce the need for methionine-loading tests to diagnose hyperhomocysteinemia.
Topics: Adult; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Prospective Studies; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Plasma total homocysteine in Mexican rural and urban women fed typical model diets.
Topics: Adolescent; Adult; Cross-Over Studies; Diet; Fasting; Female; Folic Acid; Homocysteine; Humans; Methionine; Mexico; Middle Aged; Nutritional Status; Reference Values; Rural Health; Urban Health; Vitamin B 12 | 2003 |
Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine.
Topics: Aged; Aorta; Arterial Occlusive Diseases; Biomarkers; Blood Flow Velocity; Blood Pressure; Carotid Artery, Common; Cross-Over Studies; Female; Heart Rate; Homocysteine; Humans; Male; Methionine; Middle Aged; Single-Blind Method; Time Factors; Vascular Resistance | 2003 |
Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women.
Topics: Adult; Betaine; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Fasting; Female; Homocysteine; Humans; Male; Methionine; Placebos; Reference Values | 2003 |
Variation in plasma cystathionine and its relation to changes in plasma concentrations of homocysteine and methionine in healthy subjects during a 24-h observation period.
Topics: Adult; Circadian Rhythm; Cystathionine; Fasting; Female; Food; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Methionine | 2004 |
Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Betaine; Choline; Coronary Angiography; Dietary Supplements; Drug Administration Schedule; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methionine; Methyltransferases; Middle Aged; Sarcosine; Sex Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2004 |
Comparison of the effect of oral and transdermal hormone therapy on fasting and postmethionine homocysteine levels.
Topics: Administration, Cutaneous; Administration, Oral; Estradiol; Estrogen Replacement Therapy; Fasting; Homocysteine; Humans; Methionine; Middle Aged; Norethindrone; Prospective Studies | 2004 |
Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial.
Topics: Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Double-Blind Method; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methionine; Middle Aged; Vitamin B 12; Vitamin B 6 | 2004 |
Acute hyperhomocysteinemia induces a reduction in arterial distensibility and compliance.
Topics: Acute Disease; Adult; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Compliance; Cross-Over Studies; Double-Blind Method; Femoral Artery; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidative Stress; Regional Blood Flow; Time Factors; Vasodilation | 2004 |
Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Cardiovascular Diseases; Cystathionine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Norway; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2004 |
Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a randomized crossover trial in humans.
Topics: Adult; Analysis of Variance; Area Under Curve; Cardiovascular Diseases; Cross-Over Studies; Cystine; Dietary Proteins; Fasting; Homocysteine; Humans; Male; Methionine; Serine | 2004 |
Hormone replacement influences homocysteine levels in the methionine-loading test: a randomized placebo controlled trial in postmenopausal women.
Topics: Analysis of Variance; Blood Chemical Analysis; Double-Blind Method; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Female; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Postmenopause; Pyridoxine; Treatment Outcome; Vitamin B 12 | 2004 |
Treatment of AIDS-associated myelopathy with L-methionine: a placebo-controlled study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiretroviral Therapy, Highly Active; Double-Blind Method; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Muscles; Neural Conduction; S-Adenosylmethionine; Spinal Cord Diseases; Urination | 2004 |
Evaluation of a shorter methionine loading test.
Topics: Administration, Oral; Adult; Cardiovascular Diseases; Chelating Agents; Edetic Acid; Fasting; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pre-Eclampsia; Pregnancy; Risk Factors; Time Factors | 2004 |
Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients.
Topics: Adult; Aged; Betaine; Homocysteine; Humans; Kidney Failure, Chronic; Methionine; Middle Aged; Renal Dialysis; Sarcosine | 2004 |
Effect of acute hyperhomocysteinemia on coronary flow reserve in healthy adults.
Topics: Acute Disease; Adult; Blood Flow Velocity; Coronary Circulation; Coronary Vessels; Cross-Over Studies; Echocardiography, Doppler; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Placebos | 2004 |
Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load.
Topics: Adult; Analysis of Variance; Animals; Choline; Choline Deficiency; Cross-Over Studies; Homocysteine; Humans; Lipotropic Agents; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Middle Aged; Nutritional Status; Pilot Projects | 2005 |
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.
Topics: Acetylcysteine; Adult; Arginine; Blood Flow Velocity; Brachial Artery; Cross-Over Studies; Cystathionine; Cysteine; Dipeptides; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kinetics; Male; Methionine; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vasodilation | 2005 |
Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study.
Topics: Adult; Aged; Amino Acids; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Urinary Tract Infections; Vitamin B 12; Vitamin B 6 | 2005 |
Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations.
Topics: Administration, Oral; Aged; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Fasting; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methionine; Methylation; Middle Aged | 2005 |
Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men.
Topics: Administration, Oral; Choline; Cross-Sectional Studies; Double-Blind Method; Fasting; Homocysteine; Humans; Kidney; Liver; Male; Methionine; Middle Aged; Phosphatidylcholines | 2005 |
A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: a dietary controlled, crossover trial in healthy volunteers.
Topics: Adolescent; Adult; Area Under Curve; Cardiovascular Diseases; Cross-Over Studies; Diet, Protein-Restricted; Dietary Proteins; Dose-Response Relationship, Drug; Fasting; Homocysteine; Humans; Male; Methionine; Postprandial Period; Risk Factors | 2005 |
Experimental hyperhomocysteinemia impairs coronary flow velocity reserve.
Topics: Adenosine Triphosphate; Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Biomarkers; Blood Flow Velocity; Coronary Circulation; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidative Stress; Reference Values; Research Design; Superoxide Dismutase; Time Factors | 2005 |
Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects.
Topics: Adult; Anemia, Iron-Deficiency; Brachial Artery; Cardiovascular Diseases; Chelating Agents; Double-Blind Method; Endothelium, Vascular; Female; Ferric Compounds; Ferric Oxide, Saccharated; Ferritins; Glucaric Acid; Homocysteine; Humans; Iron; Male; Methionine; Nitroglycerin; Oxidative Stress; Razoxane; Regional Blood Flow; Risk Factors; Transferrin; Tyrosine; Vasodilation | 2006 |
Homocysteine remethylation in young broilers fed varying levels of methionine, choline, and betaine.
Topics: Animals; Betaine; Chickens; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Homocysteine; Methionine; Methylation | 2006 |
Effect of methionine loading on pulse wave analysis in elderly volunteers.
Topics: Aged; Blood Flow Velocity; C-Reactive Protein; Compliance; Cross-Over Studies; Double-Blind Method; Drug Interactions; Homocysteine; Humans; Lipids; Methionine; Middle Aged; Pulsatile Flow | 2006 |
Elevation of plasma homocysteine by methionine loading increases the diastolic blood pressure response to exercise.
Topics: Adolescent; Adult; Blood Pressure; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Exercise; Homocysteine; Humans; Methionine; Middle Aged; Rest; Vasodilation | 2006 |
Effects of low- or high-dose hormone therapy on fasting and post-methionine homocysteine levels in postmenopausal women.
Topics: Dose-Response Relationship, Drug; Estradiol; Estrogen Replacement Therapy; Fasting; Female; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Norethindrone; Postmenopause; Prospective Studies; Risk Factors; Treatment Outcome; Vitamin B 12 | 2006 |
Homocysteine remethylation in broilers fed surfeit choline or betaine and varying levels and sources of methionine from eight to twenty-two days of age.
Topics: Aging; Animal Feed; Animals; Betaine; Chickens; Choline; Dose-Response Relationship, Drug; Homocysteine; Methionine; Methylation | 2006 |
Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines.
Topics: Adult; alpha-Tocopherol; Arginine; Ascorbic Acid; Cholesterol, LDL; Chronic Disease; Cytokines; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Interleukin-6; Male; Methionine; Oxidative Stress; Time Factors; Vascular Resistance; von Willebrand Factor | 2006 |
Lack of significant effects of methionine loading on endothelial function in elderly volunteers.
Topics: Aged; Aged, 80 and over; Brachial Artery; C-Reactive Protein; Cholesterol; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins; Methionine; Placebos; Regional Blood Flow; Time Factors; Triglycerides | 2006 |
Iron-dependent formation of homocysteine from methionine and other thioethers.
Topics: Adult; Area Under Curve; Cross-Over Studies; Cystathionine; Female; Homocysteine; Humans; Hydrogen-Ion Concentration; Iron; Iron Chelating Agents; Male; Methionine; S-Adenosylhomocysteine | 2007 |
Effect of excess methionine and methionine hydroxy analogue on growth performance and plasma homocysteine of growing Pekin ducks.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Ducks; Homocysteine; Methionine; Weight Gain | 2007 |
Assessment of pre- and post-methionine load homocysteine for prediction of recurrent stroke and coronary artery disease in the Vitamin Intervention for Stroke Prevention Trial.
Topics: Aged; Cohort Studies; Coronary Artery Disease; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Myocardial Infarction; Prospective Studies; Recurrence; Risk; Stroke; Vitamins | 2008 |
Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Betaine; Choline; Cross-Over Studies; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Homocysteine; Humans; Male; Methionine; Sarcosine; Statistics, Nonparametric | 2008 |
Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels.
Topics: Analysis of Variance; Antioxidants; Ascorbic Acid; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Fasting; Female; Forearm; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins, LDL; Male; Methionine; Oxidative Stress; Regional Blood Flow; Vitamin E | 2008 |
The effect of L-arginine and creatine on vascular function and homocysteine metabolism.
Topics: Aged; Arginine; Brachial Artery; Coronary Artery Disease; Creatine; Dietary Supplements; Female; Glycine; Homocysteine; Humans; Hyperemia; Male; Methionine; Middle Aged; Regional Blood Flow; Treatment Outcome; Ultrasonography; Vasodilation | 2009 |
Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women.
Topics: Adolescent; Adult; Diet; Diet Records; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Methionine; Micronutrients; Neural Tube Defects; Nutritional Status; Reference Values; Riboflavin; Time Factors; Vitamin B 12; Vitamin B 6; Young Adult | 2009 |
The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals.
Topics: Adult; Ascorbic Acid; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methionine; Oxidative Stress; Signal Transduction; Vasodilation; Vitamin E | 2010 |
Acute hyperhomocysteinemia impairs endothelium function in subjects with type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Blood Pressure; Brachial Artery; Cholesterol; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Heart Rate; Homocysteine; Humans; Hyperhomocysteinemia; Luteal Phase; Male; Methionine; Middle Aged; Triglycerides; Vasodilation; Water | 2010 |
Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder.
Topics: Biological Availability; Depressive Disorder, Major; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Psychiatric Status Rating Scales; S-Adenosylhomocysteine; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2012 |
Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans.
Topics: Adolescent; Creatine; Cysteine; Dietary Supplements; Double-Blind Method; Energy Intake; Exercise; Feeding Behavior; Folic Acid; Glycine; Healthy Volunteers; Homocysteine; Humans; Male; Methionine; S-Adenosylmethionine; Soccer; Vitamin B 12 | 2014 |
Simultaneous determination of cystathionine, total homocysteine, and methionine in dried blood spots by liquid chromatography/tandem mass spectrometry and its utility for the management of patients with homocystinuria.
Topics: Adolescent; Child; Child, Preschool; Chromatography, Liquid; Cystathionine; Disease Management; Dried Blood Spot Testing; Female; Homocysteine; Homocystinuria; Humans; Infant; Infant, Newborn; Male; Methionine; Tandem Mass Spectrometry | 2014 |
Effects of methionine supplementation on the expression of oxidative stress-related genes in acute heat stress-exposed broilers.
Topics: Animals; Animals, Inbred Strains; Antioxidants; Avian Proteins; Betaine-Homocysteine S-Methyltransferase; Biomarkers; Bird Diseases; Chickens; Diet; Energy Intake; Gene Expression Regulation, Developmental; Glutathione Peroxidase; Glutathione Synthase; Heat Stress Disorders; Homocysteine; Ion Channels; Isoenzymes; Male; Methionine; Mitochondrial Proteins; Oxidative Stress; Pectoralis Muscles; Uncoupling Protein 1; Weight Gain | 2015 |
Different responses of the retinal and cutaneous microcirculation to transient dysmetabolic conditions.
Topics: Acetylcholine; Administration, Cutaneous; Adult; Dietary Fats; Germany; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Iontophoresis; Laser-Doppler Flowmetry; Light; Male; Methionine; Microcirculation; Microvessels; Photic Stimulation; Predictive Value of Tests; Regional Blood Flow; Reproducibility of Results; Retinal Vessels; Skin; Vasodilation; Vasodilator Agents; Young Adult | 2015 |
Acute hyperlipidemia but not hyperhomocysteinemia impairs reflex regulation of the cardiovascular system.
Topics: Adrenergic beta-Agonists; Adult; Baroreflex; Blood Pressure; Cardiovascular System; Dietary Fats; Germany; Heart Rate; Hemodynamics; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Male; Methionine; Sympathetic Nervous System; Time Factors; Vagus Nerve; Vasodilator Agents; Young Adult | 2015 |
Homocysteinemia control by cysteine in cerebral vascular patients after methionine loading test: evidences in physiological and pathological conditions in cerebro-vascular and multiple sclerosis patients.
Topics: Adult; Cerebrovascular Disorders; Cysteine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Multiple Sclerosis; Serum Albumin, Human | 2016 |
Choline supplementation alters some amino acid concentrations with no change in homocysteine in children with cystic fibrosis and pancreatic insufficiency.
Topics: Adolescent; Amino Acids; Amino Acids, Branched-Chain; Child; Child, Preschool; Choline; Cystic Fibrosis; Dietary Supplements; Exocrine Pancreatic Insufficiency; Female; Homocysteine; Humans; Male; Methionine; Placebos | 2016 |
Hyperhomocysteinaemia and the risk of recurrent venous thrombosis: results from the MEGA follow-up study.
Topics: Adolescent; Adult; Aged; Female; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Recurrence; Risk Factors; Venous Thrombosis | 2019 |
Leonurine affected homocysteine-methionine metabolism based on metabolomics and gut microbiota studies of clinical trial samples.
Topics: Beijing; Double-Blind Method; Gallic Acid; Gastrointestinal Microbiome; Homocysteine; Humans; Metabolomics; Methionine | 2021 |
Pirfenidone alleviates vascular intima injury caused by hyperhomocysteinemia.
Topics: Animals; Antioxidants; Glutathione Peroxidase; Homocysteine; Hyperhomocysteinemia; Hyperplasia; Lipids; Malondialdehyde; Methionine; Oxidants; Pyridones; Rabbits; Reactive Oxygen Species; Superoxide Dismutase; Tunica Intima | 2022 |
Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial.
Topics: Betaine; Child; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; Methionine; Prospective Studies; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2022 |
1233 other study(ies) available for homocysteine and methionine
| Article | Year |
|---|---|
Purification and properties of S-adenosyl-L-homocysteine hydrolase from leaves of spinach beet.
Topics: Adenine; Cysteine; Deoxyadenosines; Homocysteine; Hydrogen-Ion Concentration; Hydrolases; Kinetics; Methionine; Plants; S-Adenosylhomocysteine; S-Adenosylmethionine | 1976 |
Formation of ethylene by Escherichia coli.
Topics: Aerobiosis; Anaerobiosis; Cell-Free System; Cysteine; Escherichia coli; Ethylenes; Homocysteine; Hydrogen-Ion Concentration; Light; Methionine; Stereoisomerism; Temperature | 1976 |
Vitamin B12--folate interrelations.
Topics: Anemia, Megaloblastic; DNA; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Glycine; Homocysteine; Humans; Methionine; Methylmalonyl-CoA Mutase; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1976 |
Collagen cross-linking. Effect of D-penicillamine on cross-linking in vitro.
Topics: Animals; Binding Sites; Bone and Bones; Cartilage; Chickens; Collagen; Homocysteine; Homocystine; Kinetics; Macromolecular Substances; Methionine; Penicillamine; Protein Binding; Protein-Lysine 6-Oxidase | 1977 |
Enzyme studies in cystathione-beta-synthase deficiency: a possible effect of elevated intracellular levels of homocystine in kinetic studies.
Topics: Cells, Cultured; Cystathionine beta-Synthase; Homocysteine; Homocystine; Humans; Hydro-Lyases; Kinetics; Methionine; Skin | 1978 |
Sulphr containing amino acids in chronic renal failure with particular reference to homocystine and cysteine-homocysteine mixed disulphide.
Topics: Amino Acids, Sulfur; Creatinine; Cysteine; Cystine; Dipeptides; Disulfides; Female; Homocysteine; Humans; Kidney Failure, Chronic; Leucine; Male; Methionine; Middle Aged; Phenylalanine; Taurine; Tyrosine | 1979 |
The behavioral effects of L-methionine and related compounds in rats and mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Betaine; Brain; Brain Chemistry; Circadian Rhythm; Conditioning, Operant; Cysteine; Electroencephalography; Eye Movements; Histidine; Homocysteine; Methionine; Mice; Mice, Inbred C57BL; Niacinamide; Rats; Serine; Sleep; Sleep, REM; Wakefulness | 1975 |
High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma 256, Walker; Cell Line; Cell Transformation, Neoplastic; Folic Acid; Homocysteine; Methionine; Simian virus 40 | 1976 |
5-methyltetrahydrofolate: synthesis and utilization in normal and SV40-transformed BHK-21 cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cricetinae; Folic Acid; Homocysteine; Kidney; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Simian virus 40; Tetrahydrofolates; Vitamin B 12 | 1977 |
Regulation of s-amino acids biosynthesis in Saccharomycopsis lipolytica.
Topics: Amino Acids, Sulfur; Arylsulfatases; Ascomycota; Cysteine; Cysteine Synthase; Homocysteine; Methionine; Mutation; Saccharomycopsis | 1979 |
Plasmodium knowlesi: in vitro biosynthesis of methionine and thymidylic acid.
Topics: Animals; Betaine; Cells, Cultured; Choline; Erythrocytes; Folic Acid; Formaldehyde; Formyltetrahydrofolates; Haplorhini; Histidine; Homocysteine; Macaca mulatta; Methionine; Plasmodium; Sarcosine; Serine; Thymidine Monophosphate; Thymine Nucleotides | 1977 |
Tumor therapy by deprivation of L-methionine: rationale and results.
Topics: Animals; Carbon-Sulfur Lyases; Cell Division; Cell Line; Culture Media; Homocysteine; Humans; Methionine; Neoplasms, Experimental; Rats | 1979 |
Inhibitors of ATP: L-methionine S-adenosyltransferase--L-methionine analogues.
Topics: Animals; Cycloleucine; Homocysteine; In Vitro Techniques; Kinetics; Liver; Methionine; Methionine Adenosyltransferase; Pyrans; Rats; Transferases | 1979 |
Cysteine-homocysteine mixed disulphide: differing plasma concentrations in normal men and women.
Topics: Adult; Amino Acids; Cysteine; Cystine; Disulfides; Female; Homocysteine; Humans; Isoleucine; Leucine; Male; Methionine; Middle Aged; Valine | 1979 |
[Methyls of biological importance].
Topics: Betaine; Carnitine; Choline; Dealkylation; Homocysteine; Humans; Lipid Metabolism; Methane; Methionine; Methylation; Phosphatidylcholines | 1979 |
De novo synthesis of methionine in normal and Brugia-infected Aedes aegypti.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aedes; Animals; Brugia; Cell-Free System; Female; Filarioidea; Homocysteine; Male; Methionine; Molecular Weight; S-Adenosylmethionine; Tetrahydrofolates; Tissue Extracts; Vitamin B 12 | 1979 |
Inhibition of immune cell function by adenosine: biochemical studies.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Animals; Cytotoxicity, Immunologic; Homocysteine; Imidazoles; Lymphocytes; Methionine; Mice; S-Adenosylmethionine; Theophylline; Uridine | 1979 |
Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines.
Topics: Age Factors; Animals; Brain; Glycine; Homocysteine; Hydrolases; Kidney; Liver; Methionine; Methionine Adenosyltransferase; Polyamines; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Factors | 1977 |
Sulfur amino acid activity of D- and L-homocystein for chicks.
Topics: Animals; Chickens; Choline; Cysteine; Diet; Female; Homocysteine; Isomerism; Male; Methionine | 1978 |
An increased requirement for methionine by transformed rat liver epithelial cells in vitro.
Topics: Betaine; Cell Division; Cell Line; Cell Transformation, Neoplastic; Culture Media; Homocysteine; Methionine | 1978 |
Methionine metabolism and vitamin B6 status in women using oral contraceptives.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Contraceptives, Oral; Contraceptives, Oral, Combined; Cystathionine; Female; Homocysteine; Humans; Methionine; Pyridoxine; Taurine | 1978 |
Maintenance of glutathione content is isolated hepatocyctes.
Topics: Animals; Cell Separation; Cysteine; Female; Glutathione; Homocysteine; In Vitro Techniques; Liver; Methionine; Rats; Serine | 1978 |
Factors affecting methionine toxicity and its alleviation in the chick.
Topics: Animals; Butyrates; Chickens; Glycine; Homocysteine; Iron; Male; Methionine; Propionates; Spleen; Threonine | 1978 |
Methionine requirement and replacement by homocysteine in tissue cultures of selected rodent and human malignant and normal cells.
Topics: Animals; Cell Division; Cell Line; Culture Media; Homocysteine; Humans; Methionine; Mice; Neoplasms, Experimental | 1978 |
The effect of homocysteine, methionine, serine and glycine on DNA synthesis by human normoblastic and megaloblastic bone marrow cells.
Topics: Bone Marrow Cells; Cell Survival; Deoxyuridine; DNA; Erythrocytes, Abnormal; Glycine; Homocysteine; Humans; Megaloblasts; Methionine; Serine; Thymidine | 1978 |
[Vitamin B 12 dependent methionine biosynthesis in pseudomonas aeruginosa].
Topics: Cysteine; Homocysteine; Methionine; Methylnitronitrosoguanidine; Mutagens; Pseudomonas aeruginosa; Stereoisomerism; Vitamin B 12 | 1975 |
Plasmodium knowlesi: in vitro biosynthesis of methionine.
Topics: Animals; Erythrocytes; Haplorhini; Homocysteine; In Vitro Techniques; Macaca mulatta; Methionine; Plasmodium; Serine; Tetrahydrofolates; Thymidine Monophosphate | 1976 |
Properties of L-methionine gamma-lyase from Pseudomonas ovalis.
Topics: Carbon-Sulfur Lyases; Homocysteine; Kinetics; Lyases; Macromolecular Substances; Magnetic Resonance Spectroscopy; Methionine; Molecular Weight; Oxidation-Reduction; Pseudomonas; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1977 |
Biosynthesis and metabolism of cystathionine in Astragalus pectinatus.
Topics: Cystathionine; Cysteine; Homocysteine; Methionine; Plants; Sulfur | 1977 |
[Utilization of inorganic sulfur sources by Staphylococcus aureus strains].
Topics: Bacterial Proteins; Cysteic Acid; Cysteine; Cystine; Genetic Variation; Homocysteine; Homocystine; Methionine; Staphylococcus aureus; Sulfides; Sulfur; Thioglycolates; Thiosulfates | 1977 |
The pathogenesis of coronary artery disease. A possible role for methionine metabolism.
Topics: Coronary Disease; Cystine; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged | 1976 |
The regulation of the degradation of methionine and of the one-carbon units derived from histidine, serine and glycine.
Topics: Animals; Carbon Dioxide; Enzyme Activation; Folic Acid; Formates; Formiminoglutamic Acid; Gluconeogenesis; Glucose; Glycine; Histidine; Homocysteine; In Vitro Techniques; Liver; Methionine; Oxidoreductases Acting on CH-NH Group Donors; Perfusion; Rats; Serine; Tetrahydrofolates | 1976 |
Existence of two levels of repression in the biosynthesis of methionine in Saccharomyces cerevisiae: effect of lomofungin on enzyme synthesis.
Topics: Antifungal Agents; Cycloheximide; Enzyme Repression; Fungal Proteins; Homocysteine; Homoserine; Lyases; Methionine; Phenazines; RNA; RNA, Messenger; S-Adenosylmethionine; Saccharomyces cerevisiae | 1975 |
Enzymatic lesions in methionine mutants of Aspergillus nidulans: role and regulation of an alternative pathway for cysteine and methionine synthesis.
Topics: Aspergillus nidulans; Cystathionine; Cysteine; Genes, Regulator; Glutathione; Homocysteine; Lyases; Methionine; Mutation; Suppression, Genetic; Taurine | 1975 |
Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity.
Topics: Adolescent; Alcohol Oxidoreductases; Diagnosis, Differential; Female; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Methionine; Methylation; Schizophrenia; Tetrahydrofolates; Vitamin B 12 | 1975 |
Methionine replacement value of N-acetylmethionine and homocysteinethiolactone hydrochloride for growing rats.
Topics: Acetates; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Diet; Homocysteine; Intestinal Absorption; Intestine, Small; Lactones; Male; Methionine; Rats | 1975 |
The effect of intrinsic factor proteins on the methylating activity of CH3-B12 coenzyme.
Topics: Animals; Cobamides; Homocysteine; Intrinsic Factor; Methionine; Methylation | 1975 |
Alleviation of inhibitory action of 5-bromode-oxyuridine by methionine in early chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Bromodeoxyuridine; Chick Embryo; Female; Fetal Diseases; Heart; Homocysteine; Methionine; Nervous System; Pregnancy | 1975 |
Biosynthesis of homocysteine sulfinic acid in the vitamin B6-deficient rat.
Topics: Animals; Homocysteine; Liver; Methionine; Organ Specificity; Rats; Vitamin B 6 Deficiency | 1975 |
Amino acids and collagen-induced platelet aggregation. Lack of effect of three amino acids that are elevated in homocystinuria.
Topics: Collagen; Female; Homocysteine; Homocystine; Homocystinuria; Humans; Male; Methionine; Platelet Aggregation; Thrombosis | 1975 |
Toxicity of various organic sulfur compounds for chicks fed crystalline amino acid diets containing threonine and glycine at their minimal dietary requirements for maximal growth.
Topics: Amino Acids, Sulfur; Animals; Chickens; Ethionine; Glycine; Homocysteine; Homocystine; Male; Methionine; Nutritional Requirements; Threonine | 1975 |
Folate-dependent enzymes in cultured Chinese hamster ovary cells: induction of 5-methyltetrahydrofolate homocysteine cobalamin methyltransferase by folate and methionine.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Culture Media; Cycloheximide; Enzyme Induction; Folic Acid; Homocysteine; Kinetics; Methionine; Methyltransferases; Thymidylate Synthase; Time Factors; Vitamin B 12 | 1975 |
The anti-folate effect of methionine on bone marrow of normal and vitamin B12 deficient rats.
Topics: Animals; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methionine; Methionine Adenosyltransferase; Rats; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1975 |
Methionine metabolism in BHK cells: selection and characterization of ethionine resistant clones.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Clone Cells; Drug Resistance; Ethionine; Folic Acid; Homocysteine; Methionine; Methionine Adenosyltransferase; Mutation; Norleucine; Quinone Reductases; Selenomethionine; Vitamin K | 1976 |
Effect of vitamin B12 and folate on biosynthesis of methionine from homocysteine in the nematode Caenorhabditis briggsae.
Topics: Animals; Choline; Folic Acid; Homocysteine; Methionine; Nematoda; Vitamin B 12 | 1976 |
Effects of glutamate and sulphur containing amino acids on ammonia toxicity and methionine sulphoximine convulsions in mice.
Topics: Amino Acids, Sulfur; Animals; Anticonvulsants; Arginine; Cystathionine; Cysteic Acid; Glutamates; Homocysteine; Male; Methionine; Methionine Sulfoximine; Mice; Quaternary Ammonium Compounds; Seizures; Taurine | 1976 |
Automated microanalysis of sulfur containing amino acids and their derivatives.
Topics: Amino Acids; Autoanalysis; Cells, Cultured; Cysteine; Cystinosis; Disulfides; Ethylmaleimide; Fibroblasts; Glutathione; Homocysteine; Humans; Methionine; Methods; Sulfur | 1976 |
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alkylation; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Homocysteine; Iodoacetamide; Methionine; Molecular Sequence Data; Recombinant Proteins; Restriction Mapping; Tetrahydrofolates; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin; Vitamin B 12 | 1992 |
Release of endogenous amino acids, including homocysteic acid and cysteine sulphinic acid, from rat hippocampal slices evoked by electrical stimulation of Schaffer collateral-commissural fibres.
Topics: Amino Acids; Animals; Aspartic Acid; Cysteine; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Homocysteine; In Vitro Techniques; Kinetics; Male; Methionine; Nerve Fibers; Neurotransmitter Agents; Pyramidal Tracts; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Plasma homocysteine in women on oral oestrogen-containing contraceptives and in men with oestrogen-treated prostatic carcinoma.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Contraceptives, Oral, Hormonal; Estradiol Congeners; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Prostatic Neoplasms; Risk Factors; Vitamin B 12 | 1992 |
Physiological analysis of mutants of Saccharomyces cerevisiae impaired in sulphate assimilation.
Topics: Cysteine; Genes, Fungal; Homocysteine; Methionine; Mutation; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; S-Adenosylmethionine; Saccharomyces cerevisiae; Sulfates; Sulfides; Sulfites; Thiosulfates | 1992 |
Methionine auxotrophy in inborn errors of cobalamin metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Cobamides; Fibroblasts; Homocysteine; Humans; Metabolism, Inborn Errors; Methionine; Vitamin B 12; Vitamin B 12 Deficiency | 1992 |
Analysis of the inhibition of commitment of murine erythroleukemia (MEL) cells to terminal maturation by N6-methyladenosine.
Topics: Adenine; Adenosine; Animals; Cell Differentiation; Cell Division; Cell Survival; Deoxyadenosines; Dimethyl Sulfoxide; Hemoglobins; Homocysteine; Leukemia, Erythroblastic, Acute; Methionine; Mice; RNA, Messenger; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status.
Topics: Adult; Aged; Aging; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Menopause; Methionine; Middle Aged; Pyridoxal Phosphate; Sex Characteristics; Vascular Diseases; Vitamin B 12 | 1992 |
Dynamic relation between reduced, oxidized, and protein-bound homocysteine and other thiol components in plasma during methionine loading in healthy men.
Topics: Adult; Cysteine; Dipeptides; Glutathione; Homocysteine; Humans; Kinetics; Male; Methionine; Oxidation-Reduction; Protein Binding; Sulfhydryl Compounds | 1992 |
Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Folic Acid; Homocysteine; Male; Methionine; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Nitrous Oxide; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Succinates; Succinic Acid; Vitamin B 12 | 1991 |
Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Homocysteine; Humans; Melanoma; Methionine; Phenotype; Tetrahydrofolates; Tumor Cells, Cultured; Vitamin B 12 | 1991 |
The cysteine transport system of Saccharomyces cerevisiae.
Topics: Biological Transport; Culture Media; Cysteine; Edetic Acid; Glutathione; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Mercuric Chloride; Methionine; Potassium Permanganate; Saccharomyces cerevisiae; Sulfuric Acids | 1991 |
[The homocysteinemia vascular risk factor. Methodologies and application to a clinical case].
Topics: Amino Acids; Arterial Occlusive Diseases; Chromatography; Homocysteine; Humans; Male; Methionine; Middle Aged; Molecular Structure; Risk Factors; Vascular Diseases | 1991 |
Betaine:homocysteine methyltransferase--a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Chickens; Fibroblasts; Homocysteine; Humans; Liver; Lymphocytes; Methionine; Methyltransferases; Sheep; Skin | 1991 |
Plasma homocysteine in venous thromboembolism.
Topics: Adult; Creatinine; Cystathionine beta-Synthase; Fasting; Female; Folic Acid; Genetic Carrier Screening; Genotype; Homocysteine; Homocystinuria; Humans; Male; Methionine; Thromboembolism; Vitamin B 12 | 1991 |
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1991 |
Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine: methionine loading of non-transformed, transformed, proliferating, and quiescent cells in culture.
Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Fibroblasts; Homocysteine; Humans; Kinetics; Liver; Liver Neoplasms, Experimental; Lymphocytes; Lymphoma; Male; Methionine; Mice; Rats; Tumor Cells, Cultured | 1991 |
Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Division; Cell Line; Culture Media; Cystamine; Cysteamine; Cysteine; Fibroblasts; Glutathione; Homocysteine; Intracellular Fluid; Leukemia, Experimental; Methionine; Methionine Sulfoximine; Mice | 1991 |
Identification of the structural gene for glucose-6-phosphate dehydrogenase in yeast. Inactivation leads to a nutritional requirement for organic sulfur.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Gene Expression Regulation, Fungal; Genes, Fungal; Genotype; Glucosephosphate Dehydrogenase; Glutathione; Homocysteine; Humans; Kinetics; Methionine; Molecular Sequence Data; Mutagenesis; Phenotype; Restriction Mapping; S-Adenosylmethionine; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid; Transcription, Genetic | 1991 |
Hyperhomocysteinemia: an independent risk factor for vascular disease.
Topics: Cerebrovascular Disorders; Coronary Disease; Cystathionine beta-Synthase; Female; Heterozygote; Homocysteine; Humans; Male; Methionine; Middle Aged; Odds Ratio; Risk Factors; Vascular Diseases | 1991 |
Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthesia, Intravenous; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Nitrous Oxide; Postoperative Period; Vitamin B 12 | 1991 |
Methionine dependency of malignant tumors.
Topics: Animals; Carbon-Sulfur Lyases; Carcinoma 256, Walker; Clostridium; Homocysteine; Methionine; Neoplasms, Experimental; Rats; Tumor Cells, Cultured | 1991 |
Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency.
Topics: Adult; Breast Feeding; Diet, Vegetarian; Female; Homocysteine; Humans; Infant; Methionine; Methylmalonic Acid; Milk, Human; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1991 |
Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ.
Topics: Alkynes; Amino Acids; Animals; Cells, Cultured; Cysteine; Glutathione; Glycine; Homocysteine; Kinetics; Liver; Male; Methionine; Pargyline; Perfusion; Rats; Rats, Inbred Strains; Serine | 1990 |
Carboxypeptidase G2 and trimetrexate cause growth delay of human colonic cancer cells in vitro.
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Cell Division; Colonic Neoplasms; Culture Media; Homocysteine; Humans; Methionine; Mice; Quinazolines; Rabbits; Trimetrexate; Tumor Cells, Cultured | 1990 |
Methionine dependence of virus-infected cells.
Topics: Animals; Cell Division; Cell Line, Transformed; Culture Media; Cytomegalovirus; Embryo, Mammalian; Homocysteine; Methionine; Mice; Mice, Inbred BALB C; Protein Biosynthesis | 1990 |
Escherichia coli metR mutants that produce a MetR activator protein with an altered homocysteine response.
Topics: Escherichia coli; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Homocysteine; Lac Operon; Methionine; Mutation; Trans-Activators; Transduction, Genetic | 1990 |
Methionine dependency of malignant tumors: a possible approach for therapy.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Movement; Colonic Neoplasms; Culture Media; Female; Homocysteine; Humans; Lung Neoplasms; Methionine; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Phenotype; Rats; Rats, Inbred Strains; Rhabdomyosarcoma; Tumor Cells, Cultured | 1990 |
The effect of excess daily methionine intake on plasma homocysteine after a methionine loading test in humans.
Topics: Adult; Aged; Amino Acids; Dietary Proteins; Female; Homocysteine; Humans; Male; Methionine; Middle Aged | 1990 |
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.
Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured | 1990 |
Enhancement by L-methionine on the contractile response of uterine segments to acetylcholine and high KCl is mainly due to enhancement of Ca uptake.
Topics: Acetylcholine; Animals; Calcium; Female; Homocysteine; In Vitro Techniques; Methionine; Potassium Chloride; Pregnancy; Rats; Tubercidin; Uterine Contraction; Uterus | 1990 |
Cobalamin neuropathy. Is S-adenosylhomocysteine toxicity a factor?
Topics: Animals; Brain Chemistry; Chiroptera; Chromatography, High Pressure Liquid; Homocysteine; Liver; Methionine; Neuromuscular Diseases; S-Adenosylhomocysteine; S-Adenosylmethionine; Valine; Vitamin B 12 Deficiency | 1990 |
Transmethylation of homocysteine to methionine: efficiency in the rat and chick.
Topics: Animals; Betaine; Body Weight; Chickens; Choline; Diet; Homocysteine; Male; Methionine; Methylation; Rats; Rats, Inbred Strains; Sarcosine; Tetrahydrofolates | 1985 |
IgE-dependent activation of mast cells is not associated with enhanced phospholipid methylation.
Topics: Animals; Cyclic AMP; Histamine Release; Homocysteine; Immunoglobulin E; In Vitro Techniques; Male; Mast Cells; Methionine; Methylation; Phosphatidylserines; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tritium; Tubercidin | 1986 |
Spontaneous and 5-azacytidine-induced revertants of methionine-dependent tumor-derived and H-ras-1-transformed cells.
Topics: Animals; Azacitidine; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Culture Media; Ethyl Methanesulfonate; Homocysteine; Methionine; Methylation; Oncogenes; Tumor Cells, Cultured | 1989 |
Quantitation of carbon flow through the hepatic folate-dependent one-carbon pool in rats.
Topics: Animals; Biological Transport; Carbon; Homocysteine; Liver; Male; Methionine; Rats; Rats, Inbred Strains; Serine; Tetrahydrofolates; Time Factors | 1989 |
Biochemical analysis of the role of transmethylation in the methionine dependence of tumor cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Biogenic Polyamines; Cell Division; Culture Media; Cystathionine beta-Synthase; Homocysteine; Humans; Methionine; Methionine Adenosyltransferase; Methylation; Phenotype; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1989 |
Hepatic content of S-adenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability.
Topics: Animals; Biomarkers; Choline Deficiency; Cysteine; Diet; Fatty Liver; Folic Acid Deficiency; Glutathione; Homocysteine; Lipids; Liver; Male; Methionine; Methylation; Niacinamide; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Homocysteine, factor VII and antithrombin III in subjects with different gene dosage for cystathionine beta-synthase.
Topics: Antithrombin III; Cystathionine beta-Synthase; Dosage Compensation, Genetic; Down Syndrome; Factor VII; Female; Homocysteine; Homozygote; Humans; Hydro-Lyases; Male; Methionine | 1989 |
Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment.
Topics: Adult; Aged; Aged, 80 and over; Fasting; Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Psoriasis; Regression Analysis | 1989 |
Agarose-selected variants of two human tumor cell lines exhibit altered methionine auxotrophy.
Topics: Cell Line; Cell Transformation, Neoplastic; Genetic Variation; Homocysteine; Humans; Melanoma; Methionine; Neuroblastoma; Nucleic Acids; S-Adenosylmethionine; Sepharose; Tumor Cells, Cultured | 1989 |
Determination of homocysteine in plasma by ion-exchange chromatography.
Topics: Chromatography, Ion Exchange; Homocysteine; Humans; Methionine; Oxidation-Reduction | 1989 |
Role of homocysteine in metR-mediated activation of the metE and metH genes in Salmonella typhimurium and Escherichia coli.
Topics: Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Homocysteine; Methionine; Methyltransferases; Salmonella typhimurium; Transcription, Genetic; Vitamin B 12 | 1989 |
Regulation of the Escherichia coli glyA gene by the metR gene product and homocysteine.
Topics: Escherichia coli; Gene Expression Regulation; Genes; Genes, Bacterial; Genotype; Glycine Hydroxymethyltransferase; Homocysteine; Methionine; Mutation; Salmonella typhimurium; Transferases | 1989 |
The effect of homocysteine on MetR regulation of metE, metR and metH expression in vitro.
Topics: Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Homocysteine; Methionine; Methyltransferases; Plasmids; Repressor Proteins; Transcription Factors | 1989 |
Genetic and biochemical analysis of the MetR activator-binding site in the metE metR control region of Salmonella typhimurium.
Topics: Base Sequence; Binding Sites; Deoxyribonuclease I; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Homocysteine; Methionine; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Protein Biosynthesis; Regulatory Sequences, Nucleic Acid; Salmonella typhimurium; Transcription Factors; Transcription, Genetic | 1989 |
Regulation of S-adenosyl methionine synthesis in the mouse embryo.
Topics: Animals; Binding, Competitive; Blastocyst; Embryo, Mammalian; Ethionine; Homocysteine; Humans; Methionine; Methylation; Mice; Mice, Inbred Strains; Morula; Oocytes; S-Adenosylmethionine | 1989 |
The simultaneous determination of oxidized and reduced glutathiones in liver tissue by ion pairing reverse phase high performance liquid chromatography with a coulometric electrochemical detector.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cystathionine; Cysteine; Electrochemistry; Glutathione; Homocysteine; Liver; Male; Methionine; Oxidation-Reduction; Rats | 1989 |
Free and protein-bound homocysteine and cysteine in cystathionine beta-synthase deficiency: interrelations during short- and long-term changes in plasma concentrations.
Topics: Adult; Betaine; Blood Proteins; Cystathionine beta-Synthase; Cysteine; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Kinetics; Male; Methionine; Protein Binding | 1989 |
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Altered methionine metabolism in metastatic variants of a human melanoma cell line.
Topics: Cell Division; Culture Media; Homocysteine; Humans; Melanoma; Methionine; Neoplasm Metastasis; S-Adenosylmethionine; Tumor Cells, Cultured; Vitamin B 12 | 1989 |
[Metabolism of monocarbons and trisomy 21: sensitivity to methotrexate].
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methionine; Methotrexate; Mitotic Index; Purines | 1986 |
[Effects of gene localization and its metabolic significance in trisomy 21].
Topics: Chromosome Mapping; Chromosomes, Human, 21-22 and Y; Cystathionine; Cystathionine beta-Synthase; Down Syndrome; Fibroblasts; Homocysteine; Homocystinuria; Humans; Methionine | 1985 |
Evidence for altered methionine methyl-group utilization in the diabetic rat's brain.
Topics: Administration, Oral; Animals; Brain; Caseins; Diabetes Mellitus, Experimental; Diet; Female; Homocysteine; Male; Methionine; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Streptozocin; Time Factors | 1988 |
Effect of dietary cystine on methionine metabolism in rat liver.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Cystine; Dietary Proteins; Homocysteine; Liver; Male; Methionine; Methyltransferases; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Serine | 1986 |
Cobalamin inactivation decreases purine and methionine synthesis in cultured human lymphoblasts.
Topics: Folic Acid; Homocysteine; Humans; Lymphocytes; Methionine; Nitrous Oxide; Oxidation-Reduction; Purines; Serine; Vitamin B 12 | 1986 |
Regulation of the metR gene of Salmonella typhimurium.
Topics: beta-Galactosidase; Cloning, Molecular; DNA, Recombinant; Gene Expression Regulation; Genes, Bacterial; Genes, Regulator; Homocysteine; Lysogeny; Methionine; Mutation; Salmonella typhimurium; Vitamin B 12 | 1987 |
Differences between premenopausal women and young men in the transamination pathway of methionine catabolism, and the protection against vascular disease.
Topics: Adolescent; Adult; Fasting; Female; Homocysteine; Humans; Male; Menopause; Methionine; Middle Aged; Sulfhydryl Compounds; Vascular Diseases | 1988 |
The role of transcobalamin II in the methionine dependency of human lymphocytes.
Topics: Cells, Cultured; Homocysteine; Humans; Lymphocyte Activation; Lymphocytes; Methionine; Transcobalamins; Vitamin B 12 | 1988 |
Growth support and toxicity of homocysteine and its effects on methionine metabolism in non-transformed and chemically transformed C3H/10T1/2 cells.
Topics: Animals; Cell Division; Cell Line; Cysteine; Dose-Response Relationship, Drug; Glutathione; Homocysteine; Homocystine; Methionine; Mice; Mice, Inbred C3H; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1988 |
Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.
Topics: Adult; Aged; Aged, 80 and over; Cysteine; Female; Folic Acid Deficiency; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Methionine; Middle Aged; Vitamin B 12 Deficiency | 1988 |
Inhibition of methyltransferase reduces the turnover of acetylcholine receptors.
Topics: Adenine; Adenosine; Animals; Dose-Response Relationship, Drug; Endocytosis; Homocysteine; In Vitro Techniques; Methionine; Methyltransferases; Muscles; Myasthenia Gravis; Phospholipids; Rats; Receptors, Nicotinic | 1988 |
Metabolic changes in the arterial wall and endothelial injury in experimental methioninaemia.
Topics: Animals; Arteries; Arteriosclerosis; Endothelium, Vascular; Female; Homocysteine; Methionine; Phthalazines; Pyridinolcarbamate; Rats; Rats, Inbred Strains | 1988 |
Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease.
Topics: Adult; Creatinine; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Vascular Diseases | 1988 |
Methionine metabolism in mammals. The methionine-sparing effect of cystine.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine; Cystathionine beta-Synthase; Cystine; Diet; Homocysteine; Liver; Male; Methionine; Methyltransferases; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1988 |
General characteristics of the superprecipitation reaction of rat crude uterine myosin B: effects of L-methionine and/or transmethylation blockers on the reaction.
Topics: Animals; Chemical Precipitation; Chickens; Electrophoresis, Polyacrylamide Gel; Female; Homocysteine; Methionine; Methylation; Myosins; Rats; Rats, Inbred Strains; Tubercidin; Uterus | 1987 |
Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line; Culture Media; Doxorubicin; Female; Fibroblasts; Homocysteine; Humans; Male; Methionine; Neoplasms; Osteosarcoma; Prostatic Neoplasms; Vincristine | 1986 |
Isozyme-specific enzyme inhibitors. 11. L-homocysteine-ATP S-C5' covalent adducts as inhibitors of rat methionine adenosyltransferases.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Homocysteine; Isoenzymes; Magnetic Resonance Spectroscopy; Methionine; Methionine Adenosyltransferase; Rats; Transferases | 1986 |
Decreased methionine synthesis in purine nucleoside treated T and B lymphoblasts: reversal by homocysteine.
Topics: B-Lymphocytes; Cell Line; Deoxyadenosines; Deoxyguanosine; Homocysteine; Humans; Kinetics; Methionine; Purine Nucleosides; T-Lymphocytes | 1986 |
Isozyme-specific enzyme inhibitors. 13. S-[5'(R)-[(N-triphosphoamino)methyl]adenosyl]-L-homocysteine, a potent inhibitor of rat methionine adenosyltransferases.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Homocysteine; Isoenzymes; Kinetics; Methionine; Methionine Adenosyltransferase; Polyphosphates; Rats; S-Adenosylmethionine; Transferases | 1987 |
Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry.
Topics: Amino Acids; Animals; Cysteine; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Methionine; Rats; Reference Values | 1987 |
Enhancement by L-methionine of contractile responses to acetylcholine and high KCl in uterine segment.
Topics: Acetylcholine; Animals; Calcium; Female; Homocysteine; In Vitro Techniques; Methionine; Methyltransferases; Muscle, Smooth; Ovariectomy; Phosphatidyl-N-Methylethanolamine N-Methyltransferase; Phosphatidylethanolamine N-Methyltransferase; Potassium Chloride; Protein O-Methyltransferase; Rats; Tubercidin; Uterine Contraction; Uterus | 1987 |
Urinary homocystine levels in a newborn infant with cystathionine synthase deficiency.
Topics: Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Infant; Male; Methionine | 1987 |
L-methionine enhances the contractile response to norepinephrine of rat vas deferens.
Topics: Animals; Calcium; Female; Guinea Pigs; Homocysteine; In Vitro Techniques; Male; Methionine; Muscle Contraction; Muscle, Smooth; Norepinephrine; Rats; Rats, Inbred Strains; Tubercidin; Vas Deferens | 1987 |
Methionine metabolism in isolated perfused livers from rats fed on zinc-deficient and restricted diets.
Topics: Animals; Butyrates; Cystathionine; Diet; Homocysteine; In Vitro Techniques; Liver; Male; Methionine; Perfusion; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Zinc | 1986 |
Dietary substitution of methionine by its precursors: influence on body growth of rats.
Topics: Animals; Diet; Growth; Homocysteine; Homocystine; Methionine; Rats | 1987 |
Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools.
Topics: Adenosine; Animals; Cells, Cultured; Drug Resistance; Homocysteine; Kinetics; Lymphoma; Methionine; Methionine Adenosyltransferase; Mice; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
L-methionine enhances the contractile responses of rat uterine smooth muscle to acetylcholine and high KCl.
Topics: Acetylcholine; Animals; Calcium Chloride; Female; Homocysteine; In Vitro Techniques; Methionine; Methylation; Phospholipids; Potassium Chloride; Proteins; Rats; Rats, Inbred Strains; Tubercidin; Uterine Contraction | 1986 |
Methionine partially corrects the impaired deoxyribonucleic acid synthesis of B12-deficient megaloblastic bone marrow cells at low concentration.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Homocysteine; Humans; Methionine; Vitamin B 12 Deficiency | 1986 |
Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Adenosylhomocysteinase; Animals; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Homocysteine; Hydrolases; In Vitro Techniques; Liver; Methionine; Rats; S-Adenosylhomocysteine | 1986 |
Acute and long-term effects of high-dose methotrexate treatment on homocysteine in plasma and urine.
Topics: Adolescent; Adult; Cells, Cultured; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Tetrahydrofolates | 1986 |
Vitamin B12 responsive homocystinuria and megaloblastic anemia: heterogeneity in methylcobalamin deficiency.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Cells, Cultured; Fibroblasts; Homocysteine; Homocystinuria; Humans; Infant; Male; Methionine; Vitamin B 12; Vitamin B 12 Deficiency | 1987 |
Folic acid responsive postmenopausal homocysteinemia.
Topics: Adult; Aging; Cystine; Dipeptides; Fasting; Female; Folic Acid; Glycine; Homocysteine; Humans; Male; Menopause; Methionine; Middle Aged; Serine | 1985 |
Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients.
Topics: Adolescent; Adult; Betaine; Child; Cystathionine beta-Synthase; Cysteine; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Male; Methionine; Middle Aged; Pyridoxine; Serine | 1985 |
Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat.
Topics: Adenine; Animals; Dithioerythritol; Half-Life; Homocysteine; Liver; Methionine; Methods; Proteins; Rats; S-Adenosylmethionine; Sulfur; Time Factors; Tissue Distribution | 1986 |
Salvage of 5'-deoxy-5'-methylthioadenosine and L-homocysteine into methionine in cells cultured in a methionine-free medium: a study of "methionine-dependence".
Topics: Adenosine; Animals; Cell Division; Cell Line; Cricetinae; Culture Media; Deoxyadenosines; Homocysteine; Humans; Methionine; Thionucleosides | 1986 |
Improved identification of heterozygotes for homocystinuria due to cystathionine synthase deficiency by the combination of methionine loading and enzyme determination in cultured fibroblasts.
Topics: Adolescent; Adult; Cells, Cultured; Clinical Enzyme Tests; Cystathionine beta-Synthase; Fasting; Female; Fibroblasts; Genetic Carrier Screening; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Male; Methionine; Middle Aged | 1985 |
Glutathione changes occurring after S-adenosylhomocysteine hydrolase inhibition.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antigens, Neoplasm; Cells, Cultured; Cystathionine; Glutathione; Homocysteine; Hydrolases; Leukemia L5178; Liver; Male; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Ethanol, the choline requirement, methylation and liver injury.
Topics: Animals; Betaine; Choline; Ethanol; Folic Acid; Homocysteine; Liver; Methionine; Methylation; Rats; Tetrahydrofolates | 1985 |
Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease.
Topics: Adult; Arterial Occlusive Diseases; Cerebrovascular Disorders; Female; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Menopause; Methionine; Middle Aged; Risk; Sex Factors | 1985 |
Effects of cysteine and structurally related compounds on ochratoxin production by Aspergillus ochraceus.
Topics: Aspergillus; Aspergillus ochraceus; Cysteine; Cystine; Ethionine; Glutathione; Homocysteine; Hydrogen-Ion Concentration; Methionine; Ochratoxins | 1985 |
Studies on a possible simultaneous differential demonstration of SH groups and S-S bonds.
Topics: Animals; Cysteine; Cystine; Disulfides; Ethylmaleimide; Evaluation Studies as Topic; Histocytochemistry; Homocysteine; Hydrogen-Ion Concentration; Indicators and Reagents; Liver; Methionine; Methods; Mice; Nerve Tissue; Staining and Labeling; Sulfhydryl Compounds | 1973 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Isolation and characterization of the methionine antagonist L-2-amino-4-methoxy-trans-3-butenoic acid from Pseudomonas aeruginosa grown on n-paraffin.
Topics: Alkenes; Aminobutyrates; Chemical Phenomena; Chemistry; Escherichia coli; Homocysteine; Methionine; Methyl Ethers; Paraffin; Pseudomonas aeruginosa | 1973 |
Correlation between the level of vitamin-B12-dependent methionine synthetase and intracellular concentration of vitamin B12 in some bacteria.
Topics: Apoenzymes; Bacterial Proteins; Carbon Radioisotopes; Chloramphenicol; Chromatium; Cobalt; Escherichia coli; Homocysteine; Methionine; Methyltransferases; Rhodospirillum rubrum; Streptomyces; Tetracycline; Tetrahydrofolates; Vitamin B 12 | 1974 |
Cysteine toxicity in Neurospora crassa: comparison of counteraction by sulphur amino acids and iron.
Topics: Amino Acids; Catalase; Cysteine; Depression, Chemical; Homocysteine; Iron; Methionine; Neurospora; Stimulation, Chemical; Sulfur Isotopes | 1970 |
A study of the behavioral disruption of mice induced by l-methionine and related compounds.
Topics: Amphetamine; Animals; Behavior, Animal; Betaine; Chlorpromazine; Cystathionine; Folic Acid; Histidine; Homocysteine; Homoserine; Male; Mescaline; Methionine; Mice; N,N-Dimethyltryptamine; Niacinamide; Serine; Social Behavior | 1974 |
Effect of pyridoxine treatment of a homocystinuric patient on the urinary excretion of some sulfur-containing amino acids.
Topics: Alanine; Amino Acids, Sulfur; Cystinuria; Disulfides; Homocysteine; Homocystine; Homocystinuria; Humans; Methionine; Pyridoxine | 1974 |
Methyl derivatives of folic acid as intermediates in the methylation of homocysteine by Escherichia coli.
Topics: Alkylation; Chromatography; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; In Vitro Techniques; Methionine; Molecular Biology; Mutation; NAD | 1964 |
Methods for the analysis and preparation of adenosylmethionine and adenosylhomocysteine.
Topics: Chromatography, Ion Exchange; Chromatography, Paper; Homocysteine; Methionine; Nucleosides; Perchlorates; Saccharomyces | 1966 |
Role of S-adenosylmethionine in methionine biosynthesis in yeast.
Topics: Adenine Nucleotides; Carbon Isotopes; Cell-Free System; Culture Media; Escherichia coli; Ethanol; Flavin-Adenine Dinucleotide; Hexosephosphates; Homocysteine; Magnesium; Methionine; NAD; Nucleosides; Pyridoxal Phosphate; Saccharomyces; Serine | 1967 |
Stabilit of the glycosidic bond of S-adenosylsulfonium compounds toward acid.
Topics: Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Drug Stability; Glycosides; Homocysteine; Hot Temperature; Hydrochloric Acid; Hydrogen-Ion Concentration; Methionine; Nucleosides; Perchlorates; Ribose; Spectrum Analysis; Sulfuric Acids | 1969 |
Methionine biosynthesis in Ochromonas malhamensis.
Topics: Adenosine Triphosphate; Alcohols; Carbon Isotopes; Cyanides; Enzyme Activation; Eukaryota; Flavin Mononucleotide; Folic Acid; Homocysteine; Kinetics; Light; Magnesium; Methionine; NAD; Oxygen; Sulfur; Transferases; Vitamin B 12 | 1969 |
Formation of the N5-methyltetrahydrofolate-homocysteine methyltransferase holoenzyme from apoenzyme and adenosyl-B 12.
Topics: Adenine Nucleotides; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Enzyme Precursors; Escherichia coli; Folic Acid; Homocysteine; Methionine; NAD; Transferases; Vitamin B 12 | 1970 |
Quantitative analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues.
Topics: Animals; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Homocysteine; Hydrolysis; Liver; Methionine; Methods; Nucleosides; Perchlorates; Rabbits; Radioisotope Dilution Technique; Rats; S-Adenosylmethionine | 1971 |
Isolation and characterization of norleucine-resistant baby hamster kidney cells.
Topics: Aminocaproates; Animals; Biological Transport; Bromodeoxyuridine; Carbon Radioisotopes; Cell Line; Cell Survival; Clone Cells; Cricetinae; Drug Resistance; Homocysteine; Kidney; Mesylates; Methionine; Methyltransferases; Nitrosoguanidines; Norleucine; Temperature; Tetrahydrofolates; Time Factors | 1974 |
Convulsant activity of homocysteine and other short-chain mercaptoacids: protection therefrom.
Topics: Animals; Betaine; Central Nervous System Stimulants; Cysteine; Glycine; Homocysteine; Male; Methionine; Phenobarbital; Pyridoxine; Rats; Serine | 1969 |
Metabolism of 35 S-sulphate and properties of APS-kinase and PAPS-reductase in Nitrobacter agilis.
Topics: Adenosine Triphosphate; Anaerobiosis; Chromatography; Cysteine; Dimercaprol; Glutathione; Homocysteine; Hydrogen-Ion Concentration; Magnesium; Methionine; Molecular Weight; NADP; Nitrobacter; Nucleosides; Nucleotidyltransferases; Oxygen; Phosphotransferases; Sulfates; Sulfides; Sulfites; Sulfur; Sulfur Isotopes; Taurine | 1971 |
Conversion of methionine to homocysteine thiolactone in liver.
Topics: Animals; Autoanalysis; Carbon Radioisotopes; Chromatography, Thin Layer; Crystallization; Homocysteine; Lactones; Liver; Methionine; Spectrophotometry, Ultraviolet | 1974 |
Methionine, DL-homocysteine thiolactone and n-acetyl-DL-methionine for ruminants.
Topics: Abomasum; Amino Acids; Amino Acids, Sulfur; Animals; Homocysteine; Intestinal Absorption; Lactones; Lysine; Male; Methionine; Rumen; Sheep; Threonine | 1974 |
Thin-layer chromatographic screening of amino acids in plasma and urine of newborns.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Arginine; Blood Proteins; Chromatography, Thin Layer; Female; Glycine; Homocysteine; Humans; Indicators and Reagents; Infant, Newborn; Infant, Premature; Lysine; Methionine; Phenylalanine; Pregnancy; Proteinuria; Tyrosine; Ultrafiltration | 1974 |
Vitamin B12-dependent methionine synthesis in Rhizobium meliloti.
Topics: Carbon Radioisotopes; Cell-Free System; Chromatography, Ion Exchange; Dithiothreitol; Flavin Mononucleotide; Homocysteine; Kinetics; Magnesium; Methionine; Methyltransferases; Oxidation-Reduction; Rhizobium; S-Adenosylmethionine; Tetrahydrofolates; Time Factors; Vitamin B 12 | 1974 |
The effect of DL-methionine, vitamin B 12, and thyroid powder on metabolism of formiminoglutamic acid in rats.
Topics: Animals; Azo Compounds; Body Weight; Diet; FIGLU Test; Folic Acid; Folic Acid Deficiency; Glutarates; Growth; Homocysteine; Liver; Male; Methionine; Methods; Rats; Tetrahydrofolates; Thyroid (USP); Thyroid Hormones; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Methionine metabolism in mammals: regulatory effects of S-adenosylhomocysteine.
Topics: Adenosine; Animals; Betaine; Chromatography, Gel; Cystathionine; Enzyme Activation; Homocysteine; Kinetics; Liver; Lyases; Methionine; Methyltransferases; Rats; Regression Analysis | 1974 |
Ethanol-induced changes in methionine metabolism in rat liver.
Topics: Animals; Cystathionine; Dietary Proteins; Ethanol; Homocysteine; Liver; Male; Methionine; Methyltransferases; Rats; S-Adenosylmethionine | 1974 |
Regulation of 5-methyltetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells.
Topics: Animals; Cells, Cultured; Cricetinae; Folic Acid; Homocysteine; Kidney; Mercaptoethanol; Methionine; Methyltransferases; Puromycin; Tetrahydrofolates; Vitamin B 12 | 1973 |
N5-methyltetrahydrofolate: homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells.
Topics: Amnion; Animals; Carbon Radioisotopes; Carcinosarcoma; Cells, Cultured; Chromatography, Ion Exchange; Culture Techniques; Fibroblasts; Homocysteine; Homocystine; Humans; Leukemia L1210; Leukemia, Myeloid; Liver; Methionine; Methyltransferases; Mice; Rats; Tetrahydrofolates; Thymus Gland | 1974 |
Transport of S-adenosylmethionine in Saccharomyces cerevisiae.
Topics: Adenosine; Azides; Biological Transport, Active; Carbon Isotopes; Chromatography, Paper; Culture Media; Cyanides; Cycloheximide; Diploidy; Ethionine; Genes; Genetics, Microbial; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Methionine; Mutation; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Temperature | 1972 |
The mechanism of S-adenosyl-L-methionine synthesis by purified preparations of bakers' yeast.
Topics: Adenosine Triphosphate; Amino Acids; Ammonium Sulfate; Carbon Isotopes; Catalysis; Chemical Precipitation; Chromatography, Ion Exchange; Cyclopentanes; Enzyme Activation; Ethanol; Fluorine; Guanosine Triphosphate; Homocysteine; Kinetics; Methionine; Models, Chemical; Pentosyltransferases; Phosphoric Acids; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Sulfides | 1972 |
[Influence of cysteine or of its sulfur-containing precursors on the development of adult human liver diploid cell lines and of heteroploid lines derived from the transformation of the latter].
Topics: Aneuploidy; Cell Division; Cell Line; Cells, Cultured; Culture Media; Cystathionine; Cysteine; Diploidy; Homocysteine; Humans; Liver; Methionine; Transformation, Genetic | 1972 |
Transductional analysis of methionine genes in Proteus mirabilis.
Topics: Aminocaproates; Drug Resistance, Microbial; Ethionine; Genes; Genes, Regulator; Genetic Linkage; Homocysteine; Methionine; Methylation; Mutation; Phenotype; Proteus; Proteus mirabilis; Transduction, Genetic | 1972 |
Regulation of homocysteine biosynthesis in Salmonella typhimurium.
Topics: Acyltransferases; Bacteriological Techniques; Carbon Isotopes; Enzyme Repression; Feedback; Genetics, Microbial; Homocysteine; Homoserine; Hydro-Lyases; L-Serine Dehydratase; Lyases; Methionine; Molecular Biology; Mutation; S-Adenosylmethionine; Salmonella typhimurium; Spectrophotometry; Succinates; Tetrahydrofolates; Tritium; Vitamin B 12 | 1972 |
[Regulatory aspects in methionine biosynthesis].
Topics: Escherichia coli; Homocysteine; Methionine; Methylation | 1972 |
Factors affecting virulence of Shigella flexneri: defective methionine synthesis in an Escherichia coli-Shigella hybrid.
Topics: Animals; Cell Survival; Cystathionine; Cysteine; Escherichia coli; Genes; Genetics, Microbial; Guinea Pigs; Homocysteine; Homoserine; Hybridization, Genetic; Methionine; RNA, Bacterial; Shigella; Shigella flexneri; Species Specificity; Temperature; Transduction, Genetic; Virulence | 1972 |
Methionine and vitamin B 12 repression and precursor induction in the regulation of homocysteine methylation in Salmonella typhimurium.
Topics: Apoproteins; Chloramphenicol; Enzyme Induction; Enzyme Precursors; Genes, Regulator; Homocysteine; Methionine; Methylation; Methyltransferases; Mutation; Oxidoreductases; Salmonella typhimurium; Tetrahydrofolates; Vitamin B 12 | 1973 |
Relationship between methionyl transfer ribonucleic acid cellular content and synthesis of methionine enzymes in Saccharomyces cerevisiae.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Carbon Isotopes; Cell-Free System; Homocysteine; Isoleucine; Ligases; Methionine; Mutation; Nucleotidyltransferases; RNA, Transfer; Saccharomyces cerevisiae; Stereoisomerism; Tritium | 1973 |
Studies on beta-cystathionase and omicron-acetylhomoserine sulfhydrylase as the enzymes of alternative methionine biosynthetic pathways in Aspergillus nidulans.
Topics: Acetylation; Aspergillus; Aspergillus nidulans; Cystathionine; Enzyme Repression; Homocysteine; Homoserine; Hydrogen Sulfide; Lyases; Methionine; Serine | 1973 |
Relationship between the cobalamin-dependent methyltransferase activities in Escherichia coli B and an E. coli B (Met H - ) mutant.
Topics: Apoproteins; Binding Sites; Carbon Isotopes; Chloromercuribenzoates; Chromatography, Gel; Cobamides; Drug Stability; Enzyme Repression; Escherichia coli; Genetics, Microbial; Homocysteine; Methionine; Methyltransferases; Mutation; Protein Binding; Temperature; Tetrahydrofolates; Tritium; Urea; Vitamin B 12 | 1973 |
Transport of vitamin B12 in Escherichia coli: genetic studies.
Topics: Binding Sites; Biological Transport, Active; Cell Membrane; Cell Wall; Cell-Free System; Chromosome Mapping; Cobalt Isotopes; Colicins; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Genes; Homocysteine; Methionine; Methyltransferases; Mutation; Receptors, Drug; Recombination, Genetic; Transduction, Genetic; Vitamin B 12 | 1973 |
The cysteine desulfhydrase of Salmonella typhimurium. Kinetic and catalytic properties.
Topics: Binding Sites; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Gel; Cystathionine; Cysteine; Drug Stability; Enzyme Activation; Enzyme Induction; Homocysteine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Lyases; Mathematics; Mercaptoethanol; Methionine; Mutation; Salmonella typhimurium; Serine; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 1973 |
Methionine biosynthesis and S-adenosylmethionine degradation during an induced morphogenesis of Candida albicans.
Topics: Candida albicans; Carbon Isotopes; Cell-Free System; Culture Media; Glycine; Homocysteine; Methionine; Methyltransferases; Morphogenesis; S-Adenosylmethionine | 1973 |
Effects of regulatory mutations upon methionine biosynthesis in Saccharomyces cerevisiae: loci eth2-eth3-eth10.
Topics: Adenosine Triphosphate; Benzene; Cell-Free System; Enzyme Repression; Ethionine; Genes; Homocysteine; Methionine; Methyltransferases; Mutation; Nucleotidyltransferases; Oxidoreductases; S-Adenosylmethionine; Saccharomyces cerevisiae; Stereoisomerism; Sulfites; Transferases | 1973 |
Effect of methionine and vitamin B-12 on the activities of methionine biosynthetic enzymes in metJ mutants of Escherichia coli K12.
Topics: Adenosine Triphosphate; Culture Media; Cystathionine; Enzyme Repression; Escherichia coli; Folic Acid; Homocysteine; Hydro-Lyases; L-Serine Dehydratase; Methionine; Methyltransferases; Mutation; Oxidoreductases; S-Adenosylmethionine; Time Factors; Transferases; Vitamin B 12 | 1973 |
Induction and repression in the S-adenosylmethionine and methionine biosynthetic systems of Saccharomyces cerevisiae.
Topics: Adenosine Triphosphate; Carbon Radioisotopes; Culture Media; Enzyme Induction; Enzyme Repression; Homocysteine; Methionine; Methyltransferases; Nucleotidyltransferases; S-Adenosylmethionine; Saccharomyces cerevisiae; Time Factors | 1973 |
S-adenosylmethionine metabolism by members of the genus Candida.
Topics: Candida; Candida albicans; Carbon Radioisotopes; Cell-Free System; Chromatography; Culture Media; Homocysteine; Methionine; Methylation; Methyltransferases; S-Adenosylmethionine; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet | 1973 |
The involvement of methionine regulatory mutants in the suppresion of b12-dependent homocysteine transmethylase (metH) mutants of Salmonella typhimurium.
Topics: Drug Resistance, Microbial; Ethionine; Genes, Regulator; Homocysteine; Methionine; Methyltransferases; Mutation; Salmonella typhimurium; Suppression, Genetic; Transduction, Genetic; Vitamin B 12 | 1974 |
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. II. Aromatic amino acids.
Topics: Adenosine; Amino Acids; Animals; Electron Transport; Escherichia coli; Homocysteine; Homoserine; Hydrolysis; Liver; Malonates; Methionine; Molecular Conformation; Nitro Compounds; Phenylalanine; Rats; S-Adenosylmethionine; Structure-Activity Relationship; Transferases; Tyrosine; Valerates; Yeasts | 1974 |
Sai-1 mutation: saccharomyces cerevisiae: characteristics of inhibition by S-adenosylmethonine and S-adenosylhomocysteine and protection by methionine.
Topics: Adenine; Carbon Isotopes; Cell Fractionation; Enterococcus faecalis; Genetics, Microbial; Homocysteine; Methionine; Mutation; Protein Biosynthesis; RNA; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Uracil | 1972 |
Folic acid and the methylation of homocysteine by Bacillus subtilis.
Topics: Alcohol Oxidoreductases; Bacillus subtilis; Chromatography, Gel; Chromatography, Thin Layer; Cobamides; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Serine; Ultrasonics; Vitamin B 12 | 1972 |
The microbial biosynthesis of methionine.
Topics: Bacillus megaterium; Basidiomycota; Candida; Carbon Isotopes; Catalase; Escherichia coli; Homocysteine; Methionine; Methylation; Methyltransferases; Serine; Tetrahydrofolate Dehydrogenase | 1972 |
Hereditary transcobalamin II deficiency: the role of transcobalamin II in vitamin B 12 -mediated reactions.
Topics: Amino Acid Metabolism, Inborn Errors; Cystathionine; DNA; Hematopoietic System; Homocysteine; Humans; Infant; Infant, Newborn; Isomerases; Leukocytes; Malonates; Methionine; Methyltransferases; Oxidation-Reduction; Propionates; Succinates; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Methionine metabolism in mammals: kinetic study of betaine-homocysteine methyltransferase.
Topics: Animals; Betaine; Buffers; Calcium Phosphates; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Cystine; Gels; Glycine; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Liver; Methionine; Methyltransferases; Rats | 1972 |
Plasma amino acid abnormalities in chronic renal failure.
Topics: Adult; Amino Acids; Cysteine; Cystine; Disulfides; Female; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Phenylalanine; Renal Dialysis; Tyrosine | 1972 |
Homocystinuria. Reduced folate levels during pyridoxine treatment.
Topics: Child; Child, Preschool; Cystine; Erythrocytes; Female; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Infant; Male; Metabolic Diseases; Methionine; Methyltransferases; Pyridoxine | 1973 |
[Cystathionuria and defective enzyme regulation].
Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Child; Chromatography, Ion Exchange; Chromatography, Paper; Cystathionine; Cysteine; Electrophoresis, Paper; Female; Homocysteine; Homocystine; Homoserine; Humans; Hydro-Lyases; Hydrocortisone; Liver; Lyases; Methionine; Pyridoxine; Sulfur | 1973 |
Betaine-homocysteine transmethylase in Pseudomonas denitrificans, a vitamin B 12 overproducer.
Topics: Betaine; Biological Assay; Cell-Free System; Chromatography, Paper; Culture Media; Enzyme Repression; Homocysteine; Hydrogen-Ion Concentration; Lactobacillus; Methionine; Methyltransferases; Mutation; Pantothenic Acid; Pseudomonas; Temperature; Vitamin B 12 | 1973 |
Effect of methionine on specific folate coenzyme pools in vitamin B 12 deficient and supplemented rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Carbon Isotopes; Chromatography, DEAE-Cellulose; Coenzymes; FIGLU Test; Folic Acid; Glutamates; Homocysteine; Liver; Male; Malonates; Methionine; Methyltransferases; Oligopeptides; Rats; Tetrahydrofolates; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
[Role of sulfated amino acids in the growth of Corynebacterium sepedonicum (Spieck, et Kott) Skapt. et Burkh].
Topics: Amino Acids; Chromatography, Paper; Colorimetry; Corynebacterium; Culture Media; Cystathionine; Glutathione; Homocysteine; Homocystine; Methionine; S-Adenosylmethionine; Stereoisomerism; Sulfur | 1973 |
[Importance and regulation of the cobalamin-dependent methionine synthetase and the betaine: homocystein methyltransferase in methionine and tetrahydrofolic acid metabolism of the rat].
Topics: Animals; Betaine; Coenzyme A; Diet; Female; Folic Acid; Homocysteine; Kidney; Liver; Methionine; Methylation; Methyltransferases; Rats; Tetrahydrofolates; Vitamin B 12 | 1973 |
Homocystinuria: studies in tissue culture.
Topics: Culture Techniques; Fibroblasts; Heterozygote; Homocysteine; Homocystine; Homocystinuria; Humans; Hydro-Lyases; L-Serine Dehydratase; Methionine; Methyltransferases; Oxidoreductases; Parents; Proteins; Pyridoxal Phosphate; Pyridoxine; Serine; Skin; Stimulation, Chemical; Tetrahydrofolates | 1973 |
A collagen defect in homocystinuria.
Topics: Adult; Aldehydes; Amino Acids; Biopsy; Borohydrides; Child; Collagen; Dialysis; Histidine; Homocysteine; Homocystine; Homocystinuria; Humans; Hydrolysis; Hydroxylysine; Methionine; Microscopy, Electron; Norleucine; Skin; Sodium; Solubility; Temperature; Time Factors; Tritium | 1973 |
[Chiro-optical properties of sulfur containing amino acids].
Topics: Alanine; Amino Acids; Circular Dichroism; Cystathionine; Cysteine; Cystine; Homocysteine; Homocystine; Hydrogen-Ion Concentration; Methionine; Molecular Conformation; Optical Rotatory Dispersion; Spectrophotometry, Ultraviolet; Sulfides; Sulfur; Temperature | 1973 |
The synthesis of taurine from sulfate. V. Regulatory modifiers of the chick liver enzyme system.
Topics: Adenosine Monophosphate; Alanine; Allosteric Regulation; Animals; Chickens; Cysteine; Ethionine; Homocysteine; Liver; Methionine; Organophosphorus Compounds; S-Adenosylmethionine; Serine; Sulfinic Acids; Sulfonic Acids; Sulfur Radioisotopes; Sulfuric Acids; Sulfurtransferases; Taurine | 1973 |
Methionine metabolism in mammals: synthesis of S-adenosylhomocysteine in rat tissues.
Topics: Adenosine; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Paper; Cysteine; Dithiothreitol; Glucagon; Glutathione; Growth Hormone; Homocysteine; Hydrocortisone; Isotope Labeling; Liver; Male; Methionine; Organ Specificity; Rats; S-Adenosylmethionine; Thyroxine; Tritium | 1973 |
Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Biopsy, Needle; Child; Child, Preschool; Cystathionine; Female; Heterozygote; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Liver; Male; Methionine; Mitochondria, Liver; Pyridoxine; Transferases; Transketolase | 1974 |
Detection of heterozygotes for homocystinuria. Study of sulphur-containing amino acids in plasma and urine after L-methionine loading.
Topics: Amino Acids, Sulfur; Chromatography, Ion Exchange; Cysteine; Cystine; Heterozygote; Homocysteine; Homocystine; Homocystinuria; Humans; Methionine; Time Factors | 1974 |
Mental retardation, megaloblastic anaemia, methylmalonic aciduria and abnormal homocysteine metabolism due to an error in vitamin B12 metabolism.
Topics: Amino Acid Isomerases; Amino Acids; Anemia, Macrocytic; Autopsy; Brain; Brain Chemistry; Cells, Cultured; Child; Culture Media; Fibroblasts; Homocysteine; Humans; Intellectual Disability; Liver; Lung; Lyases; Malonates; Metabolism, Inborn Errors; Methionine; Spleen; Vitamin B 12 | 1974 |
Reversal by serine and potentiation by glycine of the inhibitory effect of 1,2,4-triazole on growth of Salmonella typhimurium.
Topics: Adenine; Amino Acids; Cysteine; Drug Resistance, Microbial; Drug Synergism; Glycine; Homocysteine; Methionine; Mutation; Salmonella typhimurium; Serine; Triazoles | 1967 |
Enzymic synthesis of methionine: formation of a radioactive cobamide enzyme with N5-methyl-14C-tetrahydrofolate.
Topics: Carbon Isotopes; Catalysis; Chromatography, Gel; Escherichia coli; Folic Acid; Homocysteine; Kinetics; Methionine; Methylation; Transferases; Vitamin B 12 | 1967 |
Chemical propylation of vitamin-B12 transmethylase: anomalous behavior of S-adenosyl-L-methionine.
Topics: Adenine Nucleotides; Alkylation; Carbon Isotopes; Escherichia coli; Flavins; Folic Acid; Homocysteine; Methionine; Models, Chemical; Serum Albumin, Bovine; Sulfhydryl Compounds; Transferases; Vitamin B 12 | 1968 |
Rhizobium-synthesized phytototoxin: an inhibitor of beta-cystathionase in Salmonella typhimurium.
Topics: Amino Acids; Densitometry; Depression, Chemical; Homocysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Methionine; Mutation; Neurospora; Rhizobium; Salmonella typhimurium; Toxins, Biological | 1968 |
Quantitative analysis of S-adenosylhomocysteine in liver.
Topics: Animals; Carbon Isotopes; Cattle; Chickens; Chromatography, Ion Exchange; Chromatography, Thin Layer; Eels; Fishes; Homocysteine; Indicator Dilution Techniques; Liver; Methionine; Nucleosides; Rabbits; Rats | 1968 |
Binding of substrate to N5-methyl-tetrahydroteroyl-triglutamate-homocysteine transmethylase.
Topics: Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Escherichia coli; Folic Acid; Gels; Homocysteine; Methionine; Transferases | 1968 |
Regulation of the methionine-specific aspartokinase and homoserine dehydrogenase of Salmonella typhimurium.
Topics: Alcohol Oxidoreductases; Aspartic Acid; Cysteine; Feedback; Homocysteine; Methionine; Mutation; Phosphotransferases; Salmonella typhimurium | 1968 |
Escherichia coli B N5-methyltetrahydrofolate-homocysteine methyltransferase: sequential formation of bound methylcobalamin with S-adenosyl-L-methionine and N5-methyltetrahydrofolate.
Topics: Carbon Isotopes; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Escherichia coli; Folic Acid; Homocysteine; Light; Methionine; Methylation; Nucleosides; Temperature; Time Factors; Transferases; Vitamin B 12 | 1969 |
Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: activation with S-adenosyl-L-methionine and the mechanism for methyl group transfer.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Models, Biological; Nucleosides; Time Factors; Transferases; Vitamin B 12 | 1969 |
The substrate specificity of 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase.
Topics: Escherichia coli; Folic Acid; Glutamates; Homocysteine; Methionine; Methylation; Neurospora; Saccharomyces; Transferases | 1969 |
O-alkylhomoserine and methionine biosynthesis in Corynebacterium.
Topics: Amino Acids; Corynebacterium; Culture Media; Cysteine; Escherichia coli; Homocysteine; Methionine; Serine; Threonine | 1969 |
Genetic transformation in Escherichia coli.
Topics: DNA; Escherichia coli; Genetics, Microbial; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Methionine; Temperature; Transformation, Genetic; Vitamin B 12 | 1969 |
The specificity of S-adenosylmethionine derivatives in methyl transfer reactions.
Topics: Animals; Aspergillus; Binding Sites; Brain; Butyrates; Carboxy-Lyases; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Chromatography, Thin Layer; Electrophoresis; Escherichia coli; Feedback; Guinea Pigs; Histamine; Homocysteine; Isomerases; Methionine; Methylation; Nucleosides; Saccharomyces; Serotonin; Spectrophotometry; Transferases; Ultraviolet Rays | 1969 |
New methionine structural gene in Salmonella typhimurium.
Topics: Chromosome Mapping; Genetics, Microbial; Homocysteine; Methionine; Methylation; Molecular Biology; Mutation; Salmonella typhimurium; Temperature; Transduction, Genetic | 1969 |
On the role of S-adenoxylmethionine in the vitamin B12 dependent methionine biosynthesis.
Topics: Alcohols; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Escherichia coli; Flavin Mononucleotide; Folic Acid; Homocysteine; Hydroxyapatites; Kinetics; Methionine; Methods; Methylation; Nucleosides; Spectrophotometry; Sulfur; Transferases; Vitamin B 12 | 1969 |
Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase.
Topics: Carbon Isotopes; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Culture Media; Electrophoresis, Disc; Enzyme Repression; Escherichia coli; Folic Acid; Homocysteine; Magnesium; Mathematics; Methionine; Methods; Molecular Weight; Mutation; Peptides; Protamines; Quaternary Ammonium Compounds; Spectrophotometry; Transferases; Ultracentrifugation; Ultraviolet Rays; Vibration | 1970 |
Escherichia coli B 5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: catalysis by a reconstituted methyl-14C-cobalamin holoenzyme and the function of S-adenosyl-l-methionine.
Topics: Carbon Isotopes; Escherichia coli; Flavin Mononucleotide; Folic Acid; Homocysteine; Hydrogen; Kinetics; Methionine; Nucleosides; Oxygen; Protein Binding; Transferases; Vitamin B 12 | 1970 |
Escherichia coli B 5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: resolution and reconstitution of holoenzyme.
Topics: Alcohols; Carbon Isotopes; Centrifugation, Density Gradient; Chromatography, Gel; Darkness; Escherichia coli; Homocysteine; Light; Methionine; Methylation; Nucleosides; Protein Binding; Spectrophotometry; Sulfhydryl Compounds; Sulfur; Tetroses; Transferases; Tritium; Ultracentrifugation; Urea; Vibration; Vitamin B 12 | 1970 |
Spectrophotometric evidence for the formation of an Escherichia coli B B-12s methyltransferase.
Topics: Alcohols; Carbon Isotopes; Escherichia coli; Folic Acid; Free Radicals; Homocysteine; Hydrogen-Ion Concentration; Iodides; Ligases; Methionine; Methylation; Oxidation-Reduction; Spectrophotometry; Sulfur; Transferases; Ultraviolet Rays; Vitamin B 12 | 1970 |
Structure and function of E. coli formylmethionyl tRNA. I. Effect of modification of pyrimidine residues on aminoacyl synthetase recognition.
Topics: Amino Acids; Carbon Isotopes; Chromatography, DEAE-Cellulose; Escherichia coli; Formates; Homocysteine; Leucovorin; Ligases; Methionine; Nucleotides; Radiation Effects; Ribonucleases; RNA, Transfer; Spectrum Analysis; Transferases; Ultraviolet Rays | 1970 |
Modification of the composition and structure of the yeast cell wall by culture in the presence of sulfur amino acids.
Topics: Amino Acids; Candida; Carbohydrates; Cell Wall; Chromatography, Ion Exchange; Culture Media; DNA; Enzymes; Filtration; Glucosamine; Homocysteine; Intestines; Lipids; Methionine; Microscopy, Phase-Contrast; Nucleosides; Phosphorus; Proteins; Protoplasts; RNA; Saccharomyces; Snails; Solvents; Stereoisomerism | 1971 |
The vitamin B12-dependent methionine synthetase. The cycle of transmethylation.
Topics: Enzyme Induction; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Methyltransferases; Nucleosides; Oxidation-Reduction; Spectrophotometry; Transferases; Vitamin B 12 | 1971 |
Vitamin B 12 and methionine synthesis in Escherichia coli.
Topics: Acyltransferases; Aerobiosis; Alcohol Oxidoreductases; Anilides; Carbon Isotopes; Chromatography, Ion Exchange; Enzyme Repression; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Genetics, Microbial; Homocysteine; Homoserine; Kinetics; Methionine; Methyltransferases; Mutation; Serine; Succinates; Transferases; Vitamin B 12 | 1971 |
Cystinuria with hyperuricemia and methioninuria. Biochemical study of a case.
Topics: Adult; Amino Acids; Cystinuria; Female; Homocysteine; Humans; Kidney Calculi; Methionine; Penicillamine; Taurine; Threonine; Uric Acid | 1967 |
Nutrition and vitamin B12 metabolism of a soil bacterium.
Topics: Amines; Animals; Arthrobacter; Bacteria; Biological Assay; Culture Media; Edetic Acid; Escherichia coli; Homocysteine; Humans; Liver; Methionine; Oxygen Consumption; Rabbits; Rats; Soil Microbiology; Thiamine; Vitamin B 12 | 1968 |
Transductional analysis of Pseudomonas aeruginosa methionineless auxotrophs.
Topics: Cysteine; Genetics, Microbial; Homocysteine; Methionine; Methylation; Mutation; Pseudomonas aeruginosa; Transduction, Genetic; Vitamin B 12 | 1969 |
The enzymatic synthesis of fatty acid methyl esters by carboxyl group alkylation.
Topics: Acetone; Calcium; Carbon Isotopes; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Thin Layer; Enzyme Inhibitors; Enzymes; Esters; Fatty Acids; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Lipase; Methionine; Methylation; Mycobacterium; Nucleosides; Oleic Acids; Phospholipids; Solubility | 1970 |
Homocysteine-dependent transmethylases catalyzing the synthesis of methionine in germinating pea seeds.
Topics: Chromatography, Gel; Edetic Acid; Folic Acid; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Methionine; Neurospora; Nucleosides; Plants; Saccharomyces; Seeds; Transferases | 1970 |
Total synthesis of acetate from CO 2 : methyltetrahydrofolate, an intermediate, and a procedure for separation of the folates.
Topics: Acetates; Animals; Biological Assay; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Chromatography, Ion Exchange; Clostridium; Culture Media; Electron Transport; Enterococcus faecalis; Enzymes; Folic Acid; Freeze Drying; Glutamates; Homocysteine; Hydrolysis; Kidney; Methionine; Methods; Methyltransferases; Swine | 1971 |
Methionine or folate and phosphoenolpyruvate in the biosynthesis of threonine in Crithidia fasciculata.
Topics: Alanine; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Culture Media; Cystine; Eukaryota; Folic Acid; Homocysteine; Homoserine; Hydrazones; Hydroxybutyrates; Keto Acids; Methionine; Methyltransferases; Phosphoenolpyruvate; Sulfonic Acids; Sulfur Isotopes; Threonine | 1972 |
Nutrition and metabolism of sulphur amino acids in Argyrotaenia velutinana larvae.
Topics: Animals; Cystathionine; Cysteine; Female; Germ-Free Life; Homocysteine; Insecta; Larva; Male; Metamorphosis, Biological; Methionine; Pupa | 1972 |
The purification and properties of bovine pineal S-adenosylmethionine: N-acetylserotonin O-methyl transferase.
Topics: Animals; Bicarbonates; Cattle; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Enzyme Activation; Homocysteine; Kinetics; Melatonin; Methionine; Methyltransferases; Oxaloacetates; Pineal Gland; Serotonin | 1972 |
[Active center of rat liver homoserine dehydratase].
Topics: Alanine; Animals; Binding Sites; Cystathionine; Cysteine; Deamination; Homocysteine; Homoserine; Hydro-Lyases; Hydrogen Sulfide; Kinetics; Liver; Methionine; Protein Binding; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 1972 |
Homocystinuria associated with decreased methylenetetrahydrofolate reductase activity.
Topics: Adolescent; Carbon Isotopes; Coenzymes; Female; Fibroblasts; Folic Acid; Homocysteine; Homocystinuria; Humans; L-Serine Dehydratase; Male; Methionine; Methylation; Methyltransferases; Oxidoreductases; Vitamin B 12 | 1972 |
An assay for N 5 -methyltetrahydrofolate-homocysteine transmethylase activity using instant thin-layer chromatography.
Topics: Animals; Carbon Isotopes; Chromatography, Thin Layer; Folic Acid; Formaldehyde; Homocysteine; Kidney; Methionine; Methylation; Methyltransferases; S-Adenosylmethionine | 1972 |
Modification of pigmentation and cell-wall structure of Rhodotorula aurantiaca by culture in the presence of sulfur amino acids.
Topics: Acetone; Carbohydrates; Carotenoids; Cell Aggregation; Cell Fractionation; Cell Wall; Culture Media; Glycoside Hydrolases; Homocysteine; Lipids; Methionine; Mitosporic Fungi; Phosphorus; Pigmentation; Polysaccharides; Proteins; S-Adenosylmethionine; Snails; Solvents; Spectrum Analysis; Spheroplasts | 1972 |
The formation of sulphur-containing amino acids in germinating seeds of rape (Brassica napus L.).
Topics: Amino Acids; Carbon Isotopes; Cystathionine; Cysteine; Homocysteine; Homoserine; Methionine; Seeds; Sulfides; Sulfur Isotopes | 1972 |
The effect of methionine on folic acid and histidine metabolism in perfused rat liver.
Topics: Animals; Betaine; Carbon Dioxide; Carbon Isotopes; Choline; Deficiency Diseases; Drug Synergism; Ethionine; Folic Acid; Formates; Glutamates; Histidine; Homocysteine; Liver; Male; Methionine; Oxidation-Reduction; Peptides; Perfusion; Rats; Tetrahydrofolates; Vitamin B 12 Deficiency | 1972 |
Prebiotic synthesis of methionine.
Topics: Aldehydes; Aminobutyrates; Ammonia; Glutamates; Homocysteine; Homoserine; Hydrogen Sulfide; Hydrolysis; Methane; Methionine; Nitrogen; Sulfhydryl Compounds; Ultraviolet Rays; Water | 1972 |
Combined vitamin responsiveness in homocystinuria.
Topics: Adolescent; Adult; Amino Acids; Child; Drug Synergism; Female; Folic Acid; Folic Acid Deficiency; Glycine; Homocysteine; Homocystinuria; Humans; L-Serine Dehydratase; Male; Metabolic Diseases; Methionine; Methylation; Pyridoxine; Vitamin B 12 | 1972 |
Excretion of S-adenosylmethionine and S-adenosylhomocysteine in homocystinuria.
Topics: Homocysteine; Homocystine; Homocystinuria; Humans; Methionine; Nucleosides | 1971 |
The detection of heterozygotes for homocystinuria by oral loading with L-methionine.
Topics: Administration, Oral; Adult; Cysteine; Heterozygote; Homocysteine; Homocystine; Homocystinuria; Humans; Methionine | 1971 |
Mechanism of mammalian cobalamin-dependent methionine biosynthesis.
Topics: Alkylation; Animals; Carbon Isotopes; Darkness; Dithiothreitol; Electrophoresis, Disc; Enzyme Activation; Flavin Mononucleotide; Folic Acid; Homocysteine; Hydroxocobalamin; Iodides; Kidney; Kinetics; Light; Mathematics; Mercaptoethanol; Methionine; Methylation; Methyltransferases; Models, Biological; Models, Chemical; Oxidation-Reduction; Radiation Effects; S-Adenosylmethionine; Swine; Tritium | 1971 |
Ethionine and methionine metabolism by the chrysomonad flagellate Prymnesium parvum.
Topics: Animals; Carbon Isotopes; Chromatography, Paper; Culture Media; Cysteine; Ethionine; Eukaryota; Homocysteine; Methionine; Methods; Methylation; Nitrogen; Oxidation-Reduction; Sulfones; Sulfoxides; Time Factors | 1971 |
Participation of pangamic acid (vitamin B 15 ) in synthesis of methyl group of methionine and biosynthesis of corrinoids.
Topics: Animals; Culture Media; Homocysteine; Liver; Methionine; Methylation; Propionibacterium; Rats; Vitamin B Complex | 1971 |
Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue.
Topics: Aging; Alloxan; Animals; Betaine; Chromatography, Gel; Cycloheximide; Cysteine; Dactinomycin; Dietary Proteins; Enzyme Induction; Enzyme Repression; Glucagon; Homocysteine; Hormones; Liver; Male; Methionine; Methyltransferases; Organ Specificity; Rats; Tetrahydrofolates; Ultracentrifugation | 1971 |
Hyperaminoacidemia in rabbits treated with 6-azauridine triacetate.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Antimetabolites; Cystathionine; Cysteine; Homocysteine; Male; Methionine; Nucleosides; Rabbits | 1971 |
[Hereditary deficiencies of B 12 coenzymes].
Topics: Coenzymes; Female; Homocysteine; Humans; Infant; Isomerases; Male; Metabolism, Inborn Errors; Methionine; Methyltransferases; Vitamin B 12; Vitamin B 12 Deficiency | 1971 |
Oxidative deamination of sulfur amino acids by bacterial and snake venom L-amino acid oxidase.
Topics: Adenosine; Alanine; Amino Acid Oxidoreductases; Animals; Catalase; Cattle; Chromatography, Thin Layer; Cysteine; Cystine; Homocysteine; Homocystine; Hydrogen-Ion Concentration; Kinetics; Liver; Methionine; Models, Biological; Models, Structural; Oxygen Consumption; Proteus; S-Adenosylmethionine; Snakes; Species Specificity; Sulfides; Sulfur; Venoms | 1971 |
The action of adenosine thioethers, and its analytical application. ANL-7535.
Topics: Aminohydrolases; Ethers; Homocysteine; Methionine; Methylation; Spectrophotometry; Transferases | 1968 |
Enzyme regulation in the pathway of methionine biosynthesis. Molecular conversion of adenosylhomocysteine to adenosylmethionine. ANL-7409.
Topics: Amino Acids; Candida; Homocysteine; Methionine; Sulfur Isotopes | 1967 |
Pyridoxine, pantothenate and methionine effects of H2S formation by Saccharomyces cerevisiae.
Topics: Culture Media; Homocysteine; Hydrogen; Methionine; Pantothenic Acid; Pyridoxine; Saccharomyces; Serine; Sulfides | 1969 |
Two enzymic mechanisms for the methylation of homocysteine by extracts of Escherichia coli.
Topics: Alkylation; Enzymes; Escherichia coli; Homocysteine; In Vitro Techniques; Methionine; Molecular Biology; Mutation; Transferases; Ultrasonics; Vitamin B 12 | 1964 |
Cleavage of S-ribosyl-L-homocysteine by extracts from Escherichia coli.
Topics: Chromatography, Paper; Chromatography, Thin Layer; Escherichia coli; Homocysteine; In Vitro Techniques; Methionine; Ribose; Sulfhydryl Compounds | 1966 |
Methionine synthesis by extracts of Salmonella typhimurium.
Topics: Alcohol Oxidoreductases; Alkylation; Homocysteine; In Vitro Techniques; Methionine; Molecular Biology; Salmonella typhimurium; Serine; Vitamin B 12 | 1966 |
Cystathionine as a precursor of methionine in Escherichia coli and Aerobacter aerogenes.
Topics: Amino Acids; Enterobacter; Enzyme Repression; Escherichia coli; Homocysteine; Methionine; Transaminases | 1966 |
Interrelationship of adenosyl methionine and methyl-B12 in the biosynthesis of methionine.
Topics: Animals; Cattle; Coenzymes; Escherichia coli; Homocysteine; Ligases; Liver; Methionine; Nucleosides; Spectrophotometry; Swine; Vitamin B 12 | 1966 |
N5-methyltetrahydrofolate-homocysteine transmethylase. Role of S-adenosylmethionine in vitamin B12-dependent methionine synthesis.
Topics: Alkylation; Escherichia coli; Homocysteine; Iodides; Methionine; Nucleosides; Transferases; Vitamin B 12 | 1967 |
Inhibition of growth of Escherichia coli and of homoserine O-transsuccinylase by alpha-methylmethionine.
Topics: Amino Acids; Enzyme Repression; Escherichia coli; Homocysteine; Methionine; Serine; Transferases; Tritium | 1967 |
Cystathionine gamma-synthase. A pyridoxal phosphate enzyme catalyzing rapid exchanges of beta and alpha hydrogen atoms in amino acids.
Topics: Amino Acids; Butyrates; Chemical Phenomena; Chemistry; Cysteine; Homocysteine; Hydro-Lyases; Hydrogen; Ketones; Kinetics; Methionine; Pyridoxal Phosphate; Salmonella; Tritium | 1969 |
Influence of methionine pool composition on the formation of methyl-deficient transfer ribonucleic acid in Saccharomyces cerevisiae.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Culture Media; Homocysteine; Methionine; Methylation; Mutation; RNA, Transfer; Saccharomyces | 1969 |
Methyl-deficient transfer ribonucleic acid in Saccharomyces cerevisiae.
Topics: Carbon Isotopes; Homocysteine; Methionine; Mutation; RNA, Transfer; Saccharomyces | 1969 |
[Pernicious anemia--funicular spinal disease--pernicious psychosis].
Topics: Anemia, Pernicious; Female; Folic Acid; Homocysteine; Humans; Intestinal Absorption; Isomerases; Methionine; Middle Aged; Neurocognitive Disorders; Spinal Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1969 |
Quantitative determination of biologically important thiols and disulfides by gas-liquid chromatography.
Topics: Aldehydes; Chromatography, Gas; Cystamine; Cysteamine; Cysteine; Cystine; Homocysteine; Homocystine; Hot Temperature; Hydrogen-Ion Concentration; Lactones; Methionine; Methods; Penicillamine; Sulfhydryl Compounds; Sulfides | 1969 |
Vitamin B 12 dependent methionine biosynthesis in cultured mammalian cells.
Topics: Animals; Carbon Isotopes; Carcinoma; Cell Division; Cell Line; Cricetinae; Culture Media; Culture Techniques; Drug Synergism; Folic Acid; Formaldehyde; HeLa Cells; Homocysteine; Humans; Kidney; Laryngeal Neoplasms; Methionine; Stimulation, Chemical; Swine; Transferases; Vitamin B 12 | 1969 |
Role of homocysteine synthetase in an alternate route for methionine biosynthesis in Saccharomyces cerevisiae.
Topics: Amino Acids; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Gas; Crosses, Genetic; Diploidy; Ethionine; Genetics, Microbial; Haploidy; Homocysteine; Methionine; Mutation; Saccharomyces; Serine; Sulfur Isotopes; Transferases | 1970 |
The regulation of methionine synthesis and the nature of cystathionine gamma-synthase in Neurospora.
Topics: Acyltransferases; Amino Acids; Candida; Chemical Phenomena; Chemistry; Chromatography, Gel; Culture Media; Cysteine; Drug Resistance, Microbial; Ethionine; Feedback; Fungi; Genes; Genetic Code; Homocysteine; Lyases; Methionine; Mutation; Neurospora; Nucleosides; Phenotype; Saccharomyces; Species Specificity; Succinates; Sulfur Isotopes; Transferases | 1970 |
Synthesis and application in peptide chemistry of amino acids possessing an optically active selenohomocysteine skeleton.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Ethionine; Homocysteine; Methionine; Peptides; Selenium | 1970 |
Methionine toxicity and ornithine delta-aminotransferase in Chang's liver cells.
Topics: Arginine; Carbon Isotopes; Cell Division; Cell Line; Glycine; Histidine; Homocysteine; Humans; Kidney; Leucine; Liver; Methionine; Ornithine; Proteins; Serine; Stimulation, Chemical; Transaminases; Tryptophan; Tyrosine | 1970 |
Absence of cystathionase in human fetal liver: is cystine essential?
Topics: Amino Acids; Brain; Cystine; Dietary Proteins; Female; Fetus; Homocysteine; Humans; Hydro-Lyases; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature; Liver; Methionine; Placenta; Pregnancy; Transferases | 1970 |
Methylcobalamin as an intermediate in mammalian methionine biosynthesis.
Topics: Animals; Carbon Isotopes; Chromatography, Gel; Electrophoresis; Ethanol; Folic Acid; Homocysteine; Kidney; Methionine; Methylation; Nucleosides; Photochemistry; Solubility; Swine; Transferases; Vitamin B 12 | 1970 |
Methylation of homocysteine in Coprinus lagopus.
Topics: Basidiomycota; Folic Acid; Homocysteine; Methionine; Methylation; Serine; Transferases | 1970 |
Hydrogen sulphide production by yeast under conditions of methionine, pantothenate or vitamin B6 deficiency.
Topics: Homocysteine; Methionine; Mutation; Pantothenic Acid; Pyridoxine; Saccharomyces; Serine; Sulfides | 1970 |
Hydrocarbon-utilizing microorganism. Relationship of fatty acid composition and biosynthesis to hydrocarbon substrate and to vitamin B 12 level in Corynebacterium simplex.
Topics: Alkanes; Carbon Isotopes; Cobalt; Corynebacterium; Culture Media; Fatty Acids; Folic Acid; Homocysteine; Methionine; Methylation; Nucleosides; Spectrum Analysis; Transferases; Vitamin B 12 | 1970 |
Deranged B 12 metabolism: effects on sulfur amino acid metabolism.
Topics: Adenosine Triphosphate; Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Betaine; Brain Chemistry; Carbon Isotopes; Child, Preschool; Folic Acid; Homocysteine; Humans; Infant; Infant, Newborn; Isomerases; Kidney; Liver; Male; Malonates; Methionine; Methyltransferases; Transferases; Vitamin B 12 | 1970 |
Deranged B 12 metabolism: studies of fibroblasts grown in tissue culture.
Topics: Amino Acid Metabolism, Inborn Errors; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Fibroblasts; Folic Acid; Glutamates; Homocysteine; Humans; Hydroxocobalamin; Isomerases; L-Serine Dehydratase; Male; Malonates; Methionine; Methyltransferases; Propionates; Skin; Vitamin B 12 | 1970 |
Homocystinuria with methylmalonic aciduria: two cases in a sibship.
Topics: Adolescent; Carbon Isotopes; Child, Preschool; Coenzyme A; Female; Fibroblasts; Folic Acid; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Isomerases; L-Serine Dehydratase; Male; Malonates; Methionine; Methyltransferases; Pedigree; Propionates; Skin; Vitamin B 12 | 1970 |
Enzymatic deamination of adenosine sulfur compounds.
Topics: Aminohydrolases; Aspergillus; Butyrates; Chemical Phenomena; Chemistry; Ethionine; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Methionine; Nucleosides; Sulfoxides | 1971 |
Studies on vitamin B12 metabolism in HeLa cells.
Topics: Adenosine Triphosphate; Carbon Dioxide; Carbon Isotopes; Cell Line; Coenzyme A; Culture Techniques; Enzyme Activation; Folic Acid; HeLa Cells; Homocysteine; Isomerases; Malonates; Methionine; Propionates; Transferases; Vitamin B 12 | 1971 |
Detection of several non-protein amino acids in the presence of protein amino acids.
Topics: Alanine; Amino Acids; Aminobutyrates; Autoanalysis; Betaine; Chromatography; Homocysteine; Hydroxyproline; Isoleucine; Lysine; Methionine; Phenylalanine; Pimelic Acids; Proteins; Sarcosine; Taurine; Urea | 1971 |
Mutation of Saccharomyces cerevisiae preventing uptake of S-adenosylmethionine.
Topics: Adenine; Carbon Isotopes; Colorimetry; Crosses, Genetic; Culture Media; Cysteine; Genetics, Microbial; Homocysteine; Methionine; Mutation; Nucleosides; S-Adenosylmethionine; Saccharomyces; Serine; Threonine | 1971 |
Catabolism of betaine and its relationship to cobalamin overproduction.
Topics: Betaine; Carbon Dioxide; Carbon Isotopes; Chemical Phenomena; Chemistry; Choline; Coenzyme A; Glycine; Homocysteine; Methionine; Methylation; Nucleosides; Porphyrins; Pseudomonas; S-Adenosylmethionine; Succinates; Sucrose; Vitamin B 12 | 1971 |
Methionine biosynthesis in Candida albicans. I. S-adenosyl-L-methionine (or S-methyl-L-methionine): homocysteine methyltransferase in cell-free extracts from yeast-like cells.
Topics: Candida; Cell-Free System; Chemical Phenomena; Chemistry; Ethionine; Homocysteine; Hydrogen-Ion Concentration; Methionine; Methyltransferases; Proteins; Time Factors; Transferases | 1971 |
Pyridoxalphosphate and non-enzymatic synthesis of methionine.
Topics: Aluminum; Betaine; Catalysis; Chromatography, Thin Layer; Copper; Ferrocyanides; Homocysteine; Hydrogen-Ion Concentration; Methionine; Pyridoxal Phosphate | 1967 |
Identification and measurement of cysteine-homocysteine mixed disulfide in plasma.
Topics: Amino Acids; Chromatography, Ion Exchange; Cysteine; Cystine; Cystinosis; Homocysteine; Homocystine; Homocystinuria; Humans; Methionine; Sulfides | 1968 |
Cystathionine metabolism in methionine auxotrophic and wild-type strains of Saccharomyces cerevisiae.
Topics: Amino Acids; Carbon Isotopes; Cell-Free System; Chromatography; Chromatography, Gel; Cysteine; Homocysteine; Keto Acids; Methionine; Mutation; Pyruvates; Saccharomyces; Spectrophotometry; Sulfhydryl Compounds; Sulfur Isotopes | 1968 |
Observations on the metabolism of sulfur amino acid derivatives in yeast.
Topics: Amino Acids; Candida; Cysteine; Homocysteine; Methionine; Nucleosides; Saccharomyces; Sulfur; Sulfur Isotopes | 1968 |
Vitamin B 12-dependent methionine biosynthesis in HEp-2 cells.
Topics: Carbon Isotopes; Carcinoma, Squamous Cell; Culture Techniques; Homocysteine; Humans; Laryngeal Neoplasms; Ligases; Methionine; Quaternary Ammonium Compounds; Radioisotopes; Sulfates; Vitamin B 12 | 1968 |
Analysis of carboxymethylated residues in proteins by an isotopic method, and its application to the bromoacetate-ribonuclease reaction.
Topics: Acetates; Amino Acids; Aspartic Acid; Autoanalysis; Carbon Isotopes; Glycolates; Histidine; Homocysteine; Hydrogen-Ion Concentration; Indicators and Reagents; Iodoacetates; Lysine; Methionine; Methods; Proteins; Ribonucleases; Sulfonic Acids; Time Factors | 1968 |
In vivo and in vitro metabolism of S-adenosyl-L-homocysteine by Saccharomyces cerevisiae.
Topics: Bacterial Proteins; Candida; Carbon Isotopes; Cell-Free System; Chromatography, Ion Exchange; Cysteine; Electrophoresis; Homocysteine; Ion Exchange Resins; Methionine; Mitosporic Fungi; Models, Biological; Nucleic Acids; Nucleosides; Paper; Saccharomyces; Sulfur Isotopes; Tritium | 1968 |
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Homocysteine; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymidine; Transferases; Tritium; Vitamin B 12 Deficiency | 1969 |
Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae.
Topics: Alcohol Oxidoreductases; Electrophoresis; Enzyme Repression; Genes, Dominant; Heterozygote; Homocysteine; Homozygote; Kinetics; Ligases; Methionine; Molecular Biology; Nucleosides; Nucleotidyltransferases; Saccharomyces; Serine; Transferases | 1969 |
Ethionine and methionine biosynthesis in rat liver.
Topics: Animals; Betaine; Ethionine; Homocysteine; Liver; Male; Methionine; Methylation; Rats; Stereoisomerism; Stimulation, Chemical; Transferases | 1969 |
Metabolism of S-adenosyl-L-homocysteine in vivo by the rat.
Topics: Animals; Butyrates; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Homocysteine; Indicators and Reagents; Keto Acids; Male; Methionine; Models, Biological; Models, Structural; Nucleosides; Phenylhydrazines; Protein Biosynthesis; Proteins; Purines; Rats; Spectrophotometry; Sulfur; Sulfur Isotopes; Tritium | 1969 |
The specificity of S-adenosyl-L-metionine sulfonium stereoisomers in some enzyme systems.
Topics: Adenine Nucleotides; Carbon Isotopes; Carboxy-Lyases; Homocysteine; Imidazoles; Indoles; Methionine; Stereoisomerism; Transferases | 1969 |
Serine transhydroxymethylase in methionine biosynthesis in Saccharomyces cerevisiae.
Topics: Cell-Free System; Enzyme Repression; Glycine; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Methionine; Methylation; Saccharomyces; Serine; Transferases | 1969 |
A derangement in B 12 metabolism leading to homocystinemia, cystathioninemia and methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Aminobutyrates; Brain; Homocysteine; Homocystine; Homocystinuria; Humans; Infant; Kidney; Liver; Male; Malonates; Metabolism, Inborn Errors; Methionine; Sulfides; Transferases; Vitamin B 12 | 1969 |
Inhibition of cystathionine gamma-synthase by S-adenosylmethionine: A control mechanism for methionine synthesis in Neurospora.
Topics: Acyltransferases; Adenine; Chromatography, Gel; Genetics, Microbial; Homocysteine; Hydro-Lyases; L-Serine Dehydratase; Methionine; Mutation; Neurospora | 1969 |
Biosynthesis of adenosylmethionine from adenosylhomocysteine in Candida utilis.
Topics: Adenine; Candida; Carbon Isotopes; Homocysteine; Methionine; Nucleosides; Sulfates; Sulfur Isotopes; Tritium | 1969 |
Hair amino acids in cystinosis, homocystinuria, Fölling's disease and tyrosinosis.
Topics: Amino Acids; Autoanalysis; Citrulline; Cystine; Cystinosis; Female; Hair; Homocysteine; Homocystinuria; Humans; In Vitro Techniques; Male; Metabolic Diseases; Methionine; Methods; Phenylalanine; Phenylketonurias; Proline; Tyrosine | 1969 |
Uptake and utilization of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in an adenine mutant of Saccharomyces cerevisiae.
Topics: Adenine; Carbon Isotopes; Formates; Homocysteine; Methionine; Mutation; Ribosomes; RNA; RNA, Transfer; Saccharomyces; Tritium | 1969 |
Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Aminobutyrates; Arteries; Arteriosclerosis; Child; Diet; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Isomerases; Kidney; Ligases; Male; Malonates; Methionine; Vitamin B 12 | 1969 |
Inhibition by L-methionine of the growth of Euglena gracilis in a glutamic acid medium.
Topics: Acetates; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Culture Media; Cysteine; Euglena; Glutamates; Homocysteine; Methionine; Threonine; Vitamin B 12 | 1969 |
Oxidative deamination of S-adenosyl-L-homocysteine by rat kidney L-amino acid oxidase.
Topics: Amino Acid Oxidoreductases; Animals; Butyrates; Catalase; Cell-Free System; Depression, Chemical; Homocysteine; Hydrogen-Ion Concentration; Keto Acids; Kidney; Kinetics; Leucine; Liver; Manometry; Methionine; Nucleosides; Oxygen Consumption; Rats; Tritium | 1969 |
Sulfatase regulation and antibiotic synthesis in Cephalosporium acremonium.
Topics: Acremonium; Cephalosporins; Cycloheximide; Cysteine; Enzyme Induction; Enzyme Repression; Homocysteine; Methionine; Mutation; Penicillins; Sulfatases; Sulfur | 1969 |
Homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Cystinuria; Homocysteine; Humans; Infant; Methionine | 1964 |
The utilization of carbon-1 compounds by plants. II. The formation and metabolism of formate by higher plant tissues.
Topics: Edible Grain; Formates; Glycine; Glyoxylates; Homocysteine; In Vitro Techniques; Methionine; Plants; Plants, Toxic; Ricinus; Serine; Zea mays | 1965 |
Effect of homocysteine derivatives and methionine antagonists on rat liver regeneration.
Topics: Animals; Antimetabolites; Ethionine; Glycine; Homocysteine; Leucine; Liver Regeneration; Male; Methionine; Methionine Sulfoximine; Rats; Sulfoxides | 1965 |
Growth-promoting and lipotropic effect of carnitine in rats fed diets limited in protein and methionine.
Topics: Amino Acids; Animals; Betaine; Carnitine; Choline; Growth; Homocysteine; Lipid Metabolism; Liver; Male; Methionine; Protein Deficiency; Quaternary Ammonium Compounds; Rats; Threonine | 1965 |
Homocystinuria due to cystathionine synthase deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Child; Female; Homocysteine; Homocystine; Homocystinuria; Humans; Hydro-Lyases; In Vitro Techniques; Intellectual Disability; Liver; Methionine | 1965 |
Schizophrenia in a patient with a defect in methionine metabolism.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Brain; Female; Homocysteine; Humans; Intellectual Disability; Methionine; Schizophrenia | 1965 |
Homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Child; Child, Preschool; Female; Homocysteine; Homocystine; Homocystinuria; Humans; Hydro-Lyases; In Vitro Techniques; Intellectual Disability; Intracranial Embolism and Thrombosis; Lens, Crystalline; Male; Methionine; Seizures | 1965 |
[Action of higher homologs of methionine in bromobenzene poisoning].
Topics: Animals; Benzene; Chemical and Drug Induced Liver Injury; Diuresis; Ethionine; Homocysteine; Hydrocarbons, Halogenated; Lipids; Liver; Methionine; Rats | 1965 |
The inhibition of cerebral glutamine synthetase by structural analogs of the convulsant dl-methionine sulfoximine.
Topics: Animals; Cerebral Cortex; Cysteine; Enzymes; Glutamine; Homocysteine; In Vitro Techniques; Ligases; Methionine; Methionine Sulfoximine; Rats | 1966 |
Inhibitory effect of cysteine on Streptomyces griseus phage reproduction.
Topics: Bacteriophages; Cysteine; Glutathione; Homocysteine; Isoleucine; Methionine; Streptomyces; Thioglycolates; Threonine | 1966 |
The biosynthesis of the methyl groups of choline in Ochromonas malhamensis.
Topics: Alkylation; Amino Alcohols; Choline; Eukaryota; Folic Acid; Homocysteine; In Vitro Techniques; Methionine; Microsomes; Mitochondria; Nucleosides; Phosphatidylcholines; Subcellular Fractions; Vitamin B 12 | 1966 |
Homocystinuria. A recently discovered cause of mental defect and cerebrovascular thrombosis.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Animals; Blood; Blood Coagulation Disorders; Brain; Child; Child, Preschool; Cystine; Electroencephalography; Female; Homocysteine; Homocystine; Homocystinuria; Humans; In Vitro Techniques; Infant; Intellectual Disability; Intracranial Embolism and Thrombosis; Kidney Diseases; Male; Methionine; Taurine; Urine | 1966 |
Linked transduction in Proteus mirabilis.
Topics: Arginine; Citrulline; Homocysteine; Methionine; Mutation; Proteus; Radiation Effects; Ultraviolet Rays; Uracil | 1966 |
Enthalpy changes accompanying the transfer of a methyl group from S-adenosylmethionine and other sulfonium compounds to homocysteine.
Topics: Alkylation; Chemical Phenomena; Chemistry, Physical; Homocysteine; Methionine; Nucleosides; Solutions; Sulfur; Thermodynamics | 1966 |
Interrelationships of sulfur amino acids in the pool and cellular protein of Neurospora crassa.
Topics: Amino Acids; Cysteine; Homocysteine; Kinetics; Methionine; Neurospora; Protein Biosynthesis; Sulfates; Sulfur Isotopes | 1966 |
Folic acid and biotin on the metabolism of 1 carbon unit: utilization of beta-carbon of serine for the synthesis of methionine.
Topics: Animals; Biotin; Folic Acid Deficiency; Homocysteine; In Vitro Techniques; Liver; Methionine; Rats; Serine; Vitamin B Deficiency | 1966 |
First defined media for leptomonas spp. from insects.
Topics: Choline; Culture Media; Eukaryota; Glycine; Homocysteine; Insecta; Lactones; Methionine; Pantothenic Acid; Vitamin B 12 | 1966 |
Homocystinuria: an observation on the inheritance of cystathionine synthase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Chromatography, Paper; Cystine; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Intellectual Disability; Lens, Crystalline; Male; Methionine; Middle Aged; Sulfur Isotopes | 1966 |
[Fatty acids from hepatic lipids of rats treated with superior homologues of L- and D-methionine].
Topics: Amino Acids; Animals; Ethionine; Fatty Acids; Homocysteine; Lipids; Liver; Methionine; Rats | 1966 |
Homocysteine and cysteine synthetases of Neurospora crassa. Purification, properties, and feedback control of activity.
Topics: Chromatography; Cysteine; Enzyme Repression; Homocysteine; Hydro-Lyases; Kinetics; Methionine; Mutation; Neurospora | 1967 |
A study of the sulphur amino acids of rat tissues.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Brain Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Cysteine; Glutathione; Homocysteine; In Vitro Techniques; Liver; Male; Methionine; Rats; Sulfur Isotopes | 1967 |
The conformation of ribonucleosides in solution. The effect of structure on the orientation of the base.
Topics: Chemical Phenomena; Chemistry, Physical; Homocysteine; Methionine; Nucleosides; Solutions; Spectrophotometry | 1967 |
Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Buffers; Carbon Isotopes; Centrifugation; Enzymes; Feedback; Folic Acid; Homocysteine; Liver; Methionine; Rats | 1967 |
Sulfur-containing amino acids in the plasma and urine of homocystinurics.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child; Child, Preschool; Chromatography, Paper; Homocysteine; Homocystine; Homocystinuria; Humans; Infant; Infant, Newborn; Intellectual Disability; Iodoacetates; Methionine; Sulfoxides; Sulfur; Ultraviolet Rays | 1967 |
Synthesis of homocysteine and cysteine by enzyme extracts of spinach.
Topics: Amino Acids; Chromatography, Paper; Cysteine; Electrophoresis; Homocysteine; In Vitro Techniques; Methionine; Plant Extracts; Plants, Edible; Serine; Sulfides; Sulfur Isotopes; Threonine; Vegetables | 1967 |
Evidence for a methionyl residue in the active site of isocitrate dehydrogenase.
Topics: Amino Acids; Animals; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Paper; Homocysteine; In Vitro Techniques; Iodoacetates; Isocitrate Dehydrogenase; Methionine; Myocardium; Swine | 1967 |
Some mutants of Saccharomyces cerevisiae inhibited by adenoylmethionine and adenosylhomocysteine.
Topics: Adenine; Carbon Isotopes; Culture Media; Cysteine; Genetic Complementation Test; Genetics, Microbial; Homocysteine; Methionine; Mutation; Nucleosides; Saccharomyces; Transferases | 1967 |
Formation of taurine and isethionic acid in rat brain.
Topics: Amino Acids; Animals; Brain; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Cysteine; Homocysteine; Methionine; Rats; Sulfonic Acids; Sulfur; Sulfur Isotopes; Taurine | 1967 |
Decreased rates of methionine synthesis by methylene tetrahydrofolate reductase-deficient fibroblasts and lymphoblasts.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Female; Fibroblasts; Homocysteine; Humans; Infant; Lymphocytes; Male; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Neurotransmitter Agents; Oxidoreductases; Psychomotor Disorders; Skin | 1981 |
Labile methyl group balances in the human: the role of sarcosine.
Topics: Adolescent; Child; Choline; Cystine; Diet; Female; Glycine; Homocysteine; Humans; Male; Methionine; Methylation; Nitrogen; Phosphatidylcholines; Sarcosine | 1980 |
Fragile X expression is decreased by 5-azacytidine and S-adenosylhomocysteine.
Topics: Azacitidine; Cell Line; Culture Media; DNA; Dose-Response Relationship, Drug; Floxuridine; Fragile X Syndrome; Homocysteine; Humans; Karyotyping; Methionine; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Chromosome Aberrations | 1983 |
Methotrexate hepatotoxicity.
Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides | 1984 |
Reversible growth arrest in simian virus 40-transformed human fibroblasts.
Topics: Cell Cycle; Cell Transformation, Viral; Cells, Cultured; Culture Media; Homocysteine; Humans; Methionine; Simian virus 40 | 1980 |
Effect of methionine deprivation on S-adenosylmethionine decarboxylase of tumour cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Bucladesine; Carboxy-Lyases; Carcinoma 256, Walker; Cells, Cultured; Cyclic AMP; Cycloleucine; Enzyme Induction; Homocysteine; Kinetics; Lymphoma; Methionine; Polyamines | 1981 |
Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells.
Topics: Cell Division; Cell Line; Cell Transformation, Viral; Homocysteine; Humans; Methionine; Neoplasms, Experimental; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1982 |
Decreased methionine synthesis in purine nucleoside-treated T and B lymphoblasts and reversal by homocysteine.
Topics: Adenosine; B-Lymphocytes; Cell Line; Deoxyadenosines; Deoxyguanosine; Guanosine; Homocysteine; Humans; Inosine; Lymphocyte Activation; Methionine; Purine Nucleosides; T-Lymphocytes; Vidarabine | 1984 |
Endothelial cell dysfunction in homocystinuria.
Topics: Cells, Cultured; Chromium Radioisotopes; Endothelium; Heterozygote; Homocysteine; Homocystine; Homocystinuria; Humans; Infant, Newborn; Male; Methionine; Platelet Aggregation; Umbilical Cord | 1983 |
Elevated overall rates of transmethylation in cell lines from diverse human tumors.
Topics: Adenosylhomocysteinase; Cell Line; Homocysteine; Humans; Hydrolases; Methionine; Methylation; Neoplasms, Experimental; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1984 |
Brain methylation and epileptogenesis: the case of methionine sulfoximine.
Topics: Adenosine; Animals; Brain; Epilepsy; Histamine; Homocysteine; Methionine; Methionine Sulfoximine; Methylation; Methylhistamines; Mice; Nerve Tissue Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Globin-methionine complexes formed during labelling studies.
Topics: Chromatography, Thin Layer; Cysteine; Electrophoresis, Cellulose Acetate; Globins; Homocysteine; Humans; Isotope Labeling; Leucine; Methionine; Molecular Weight | 1984 |
Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.
Topics: Adenosine; Aspartic Acid; Erythrocyte Membrane; Erythrocytes; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Pyridoxine treatment does not prevent homocystinemia after methionine loading in adult homocystinuria patients.
Topics: Adult; Cysteine; Cystine; Female; Homocysteine; Homocystine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Pyridoxine | 1983 |
Unique efficiency of methionine metabolism in premenopausal women may protect against vascular disease in the reproductive years.
Topics: Adult; Age Factors; Arterial Occlusive Diseases; Cysteine; Female; Homocysteine; Humans; Male; Menstruation; Methionine; Sex Factors | 1983 |
The metabolic defect of methionine dependence occurs frequently in human tumor cell lines.
Topics: Cell Line; Culture Media; Homocysteine; Humans; Methionine; Neoplasms | 1983 |
Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria.
Topics: Adult; Amino Acids, Sulfur; Aminobutyrates; Coronary Disease; Diseases in Twins; Female; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Myocardial Infarction; Pregnancy; Twins, Monozygotic | 1983 |
Utilization of preformed and endogenously synthesized methionine by cells in tissue culture.
Topics: Animals; Bone Marrow; Cell Division; Cell Line; Culture Media; Embryo, Mammalian; Homocysteine; Humans; Lung; Methionine; Mice; Neoplasms, Experimental; Tetrahydrofolates | 1984 |
Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines.
Topics: Cell Line; Homocysteine; Humans; Methionine; Models, Biological; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Betaine delays the onset of neurological impairment in nitrous oxide-induced vitamin B-12 deficiency in fruit bats.
Topics: Animals; Ataxia; Betaine; Body Weight; Chiroptera; Diet; Homocysteine; Methionine; Nitrous Oxide; Vitamin B 12 Deficiency | 1984 |
Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosine Deaminase; Adenosylhomocysteinase; Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Homocysteine; Hydrolases; In Vitro Techniques; Liver; Male; Methionine; Methyltransferases; Models, Biological; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Production of convulsions in mice by the combination of methionine and homocysteine.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Ethionine; Female; Homocysteine; Male; Methionine; Mice; Pentylenetetrazole; Seizures | 1980 |
Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Epoprostenol; Fatty Acids, Unsaturated; Homocysteine; Homocystine; Humans; Hydroxy Acids; Hydroxyeicosatetraenoic Acids; Methionine; Thromboxane A2; Umbilical Arteries | 1982 |
Increased plasma copper in patients with homocystinuria due to cystathionine beta-synthase deficiency.
Topics: Adolescent; Adult; Age Factors; Amino Acids, Sulfur; Ceruloplasmin; Child; Child, Preschool; Copper; Cystathionine beta-Synthase; Female; Heterozygote; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Male; Methionine; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Sex Factors; Superoxide Dismutase | 1983 |
Formation and utilization of methionine by rat liver cells in culture.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Homocysteine; Leucine; Liver; Methionine; Rats; Vitamin B 12 | 1983 |
Differential sensitivity of normal and leukaemic haemopoietic cells to methionine deprivation by L-methioninase.
Topics: Adenosylmethionine Decarboxylase; Carbon-Sulfur Lyases; Hematopoietic Stem Cells; Homocysteine; Humans; Leukemia; Lyases; Methionine; Methionine Adenosyltransferase; Thymidine; Time Factors; tRNA Methyltransferases | 1983 |
Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Folic Acid Deficiency; Homocysteine; Kinetics; Liver; Lung; Male; Methionine; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Testis; Tissue Distribution; Vitamin B 12 Deficiency | 1983 |
Measurements of S-adenosylmethionine and L-homocysteine metabolism in cultured human lymphoid cells.
Topics: Cells, Cultured; Homocysteine; Humans; Lymphocytes; Mathematics; Methionine; S-Adenosylmethionine; Time Factors | 1983 |
The elevated requirement for methionine by transformed rat liver epithelial cells in vitro.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Culture Media; Homocysteine; Kinetics; Liver; Methionine; Rats | 1980 |
Methionine regulation of N-5-methyltetrahydrofolate: homocysteine methyltransferase and its influence on the growth and protein synthesis in normal, neoplastic, and transformed cells in culture.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Induction; Female; Fibroblasts; HeLa Cells; Homocysteine; Homocysteine S-Methyltransferase; Humans; Methionine; Methyltransferases; Pregnancy; Protein Biosynthesis; Rats | 1982 |
Methionine metabolism in mammals: concentration of metabolites in rat tissues.
Topics: Amino Acids, Sulfur; Animals; Cysteine; Cystine; Dietary Proteins; Homeostasis; Homocysteine; Male; Methionine; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfhydryl Compounds; Tissue Distribution | 1982 |
Methionine biosynthesis in Brevibacterium flavum: properties and essential role of O-acetylhomoserine sulfhydrylase.
Topics: Brevibacterium; Carbon-Oxygen Lyases; Cysteine Synthase; Homocysteine; Kinetics; Lyases; Methionine; Multienzyme Complexes; Saccharomyces cerevisiae Proteins; Substrate Specificity | 1982 |
Experimental homocysteinemia in pigs: comparison with studies in sixteen homocystinuric patients.
Topics: Adolescent; Adult; Amino Acids; Aminobutyrates; Animals; Child; Child, Preschool; Dipeptides; Disease Models, Animal; Homocysteine; Homocystine; Homocystinuria; Humans; Kinetics; Methionine; Middle Aged; Swine; Taurine | 1982 |
Methionine biosynthesis and vidarabine therapy.
Topics: Adenosylhomocysteinase; Female; Homocysteine; Humans; Hydrolases; Male; Methionine; Vidarabine | 1982 |
Transsulphuration and methylation of homocysteine in control and mutant human fibroblasts.
Topics: Cell Line; Cells, Cultured; Cystathionine beta-Synthase; Cysteine; Fibroblasts; Homocysteine; Homocystinuria; Humans; Methionine; Methylation; Mutation; Skin; Sulfur Radioisotopes | 1982 |
The preparation of [35S]homocysteine thiolactone free of [35S]methionine.
Topics: Homocysteine; Isotope Labeling; Methionine; Sulfur Radioisotopes | 1982 |
Methionine metabolism in Walker carcinosarcoma in vitro.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma 256, Walker; Cell Survival; Cells, Cultured; Homocysteine; Methionine; Methotrexate; Sulfhydryl Compounds; Thymidine | 1980 |
Effect of methionine replacement by homocysteine on the growth of cells.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Culture Media; Homocysteine; Humans; Methionine; Mice; Neoplasms; Rats | 1980 |
Dependence on exogenous methionine of rat sarcoma and murine leukemia cells in culture.
Topics: Animals; Ascitic Fluid; Cell Survival; Cells, Cultured; Culture Media; Homocysteine; Leukemia L5178; Leukemia, Experimental; Methionine; Mice; Rats; Sarcoma, Experimental | 1980 |
Effect of 1-aminoproline on methionine metabolism in rats.
Topics: Animals; Cystathionine; Homocysteine; Male; Methionine; Proline; Rats; Stereoisomerism; Sulfoxides | 1981 |
Methionine requirement of normal and leukaemic haemopoietic cells in short term cultures.
Topics: Adult; Aged; Bone Marrow; Cells, Cultured; Child; Culture Media; Female; Hematologic Diseases; Homocysteine; Humans; Kinetics; Leukemia; Male; Methionine; Middle Aged; Time Factors | 1981 |
Plasma cyst(e)ine in homocyst(e)inemia.
Topics: Blood Proteins; Cysteine; Cystine; Female; Homocysteine; Homocystine; Homocystinuria; Humans; Male; Methionine; Protein Binding | 1981 |
Congenital methylmalonic aciduria--homocystinuria with megaloblastic anemia: observations on response to hydroxocobalamin and on the effect of homocysteine and methionine on the deoxyuridine suppression test.
Topics: Anemia, Megaloblastic; Deoxyuridine; DNA; Female; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Infant; Infant, Newborn; Malonates; Methionine; Methylmalonic Acid; Myoclonus; Thymidine | 1980 |
Induction of betaine: homocysteine methyltransferase in some murine cells cultured in vitro.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Cell Line; Cells, Cultured; Cricetinae; Enzyme Induction; Fibroblasts; Homocysteine; Kinetics; L Cells; Leukemia L1210; Methionine; Methyltransferases; Mice | 1980 |
Involvement of the cystathionine pathway in the biosynthesis of glutathione by isolated rat hepatocytes.
Topics: Alkynes; Animals; Cystathionine; Cystathionine gamma-Lyase; Glutathione; Glycine; Homocysteine; In Vitro Techniques; Kinetics; Liver; Male; Methionine; Rats | 1980 |
Effect of methionine deprivation on methylation and synthesis of macromolecules.
Topics: Animals; Cell Line; DNA, Neoplasm; Homocysteine; Humans; Macromolecular Substances; Methionine; Methylation; Mice; Neoplasm Proteins; Neoplasms, Experimental; Rats; RNA, Neoplasm | 1980 |
S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocystein, and adenosine.
Topics: Adenosine; Animals; DNA; Female; Histones; Homocysteine; Kinetics; Liver; Methionine; Perfusion; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Dietary methionine does not reduce penetrance in curly tail mice but causes a phenotype-specific decrease in embryonic growth.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Female; Homocysteine; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Neural Tube Defects; Phenotype; Pregnancy; Weight Gain | 1995 |
Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from the NHLBI Family Heart Study.
Topics: Adult; Aged; Cohort Studies; Coronary Disease; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Predictive Value of Tests; Risk Factors | 1995 |
Alterations of methionine fluxes and incorporation in intestines of miniature pigs fed a diet high in caseinate are restricted by angiotensin-converting enzyme inhibitor.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Caseins; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Epithelium; Homocysteine; Hydrochlorothiazide; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methionine; Random Allocation; Sodium Chloride Symporter Inhibitors; Swine; Swine, Miniature; Tritium | 1995 |
Are patients with homocystinuria being missed?
Topics: Child; Chromatography, High Pressure Liquid; Diagnosis, Differential; Homocysteine; Homocystinuria; Humans; Methionine; Pyridoxal Phosphate | 1995 |
Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment.
Topics: Animals; Carbon Tetrachloride; Cystathionine; DNA; Folic Acid; Homocysteine; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1995 |
Effective homocysteine metabolism may protect South African blacks against coronary heart disease.
Topics: Adult; Black People; Coronary Disease; Folic Acid; Homocysteine; Humans; Male; Methionine; South Africa; Vitamin B 12; Vitamins; White People | 1995 |
Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease.
Topics: Adult; Arterial Occlusive Diseases; Cross-Sectional Studies; Female; Homocysteine; Humans; Male; Methionine; Risk Factors; Sex Factors; Thromboembolism | 1995 |
Metabolism of homocysteine, its relation to the other cellular thiols and its mechanism of cell damage in a cell culture line (human histiocytic cell line U-937).
Topics: Arteriosclerosis; Cell Line; Copper; Cystine; Glutathione; Histiocytes; Homocysteine; Humans; Methionine; Sulfhydryl Compounds | 1995 |
Plasma homocysteine levels in patients with deep venous thrombosis.
Topics: Adult; Dipeptides; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Thrombophlebitis | 1995 |
Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.
Topics: Adolescent; Adult; Aged; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Chromatography; Creatinine; Cystathionine beta-Synthase; Female; Folic Acid Deficiency; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Metabolism, Inborn Errors; Methionine; Methyltransferases; Middle Aged; Rats; Rats, Sprague-Dawley; Reference Values; Renal Insufficiency; Sarcosine; Vitamin B 12; Vitamin B 12 Deficiency | 1993 |
Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?
Topics: Adult; Aged; Aged, 80 and over; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Recurrence; Risk Factors; Thrombophlebitis | 1995 |
Prevention of neural tube defects by and toxicity of L-homocysteine in cultured postimplantation rat embryos.
Topics: Adenosylhomocysteinase; Animals; Catalase; Copper; Copper Sulfate; Culture Techniques; Drug Interactions; Embryonic and Fetal Development; Embryonic Development; Female; Homocysteine; Homocystine; Hydrolases; Methionine; Neural Tube Defects; Oxidation-Reduction; Pregnancy; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Stereoisomerism; Teratogens; Vitamin B 12 | 1994 |
The methyltransferase inhibitor Neplanocin A interferes with influenza virus replication by a mechanism different from that of 3-deazaadenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Chick Embryo; Drug Synergism; Homocysteine; Hydrolases; Influenza A virus; Methionine; Methyltransferases; RNA Caps; RNA, Viral; S-Adenosylhomocysteine; Tubercidin; Viral Proteins; Virus Replication | 1995 |
Validation of abbreviated oral methionine-loading test.
Topics: Adult; Aged; Cystathionine beta-Synthase; Female; Homocysteine; Humans; Male; Methionine; Middle Aged | 1995 |
Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cholesterol; Cholesterol, LDL; Cohort Studies; Female; Homocysteine; Homozygote; Humans; Lipid Peroxidation; Lipoproteins, LDL; Male; Methionine; Oxidation-Reduction; Reference Values; Thiobarbituric Acid Reactive Substances; Vitamin E | 1995 |
Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts.
Topics: Alkynes; Carbon-Oxygen Lyases; Carbon-Sulfur Lyases; Cell Compartmentation; Chloroplasts; Cystathionine; Glycine; Homocysteine; Homoserine; Kinetics; Lyases; Methionine; Molecular Weight; Pargyline; Plant Leaves; Protein Conformation; Pyridoxal Phosphate; Spectrophotometry; Spinacia oleracea | 1995 |
Methionine biosynthesis in higher plants. II. Purification and characterization of cystathionine beta-lyase from spinach chloroplasts.
Topics: Aminobutyrates; Cell Compartmentation; Chloroplasts; Cystathionine; Homocysteine; Kinetics; Lyases; Methionine; Plant Leaves; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Spectrophotometry; Spinacia oleracea | 1995 |
Hyperhomocysteinemia-induced vascular damage in the minipig. Captopril-hydrochlorothiazide combination prevents elastic alterations.
Topics: Animals; Blood Vessels; Captopril; Caseins; Diet; Drug Combinations; Hemorheology; Hindlimb; Homocysteine; Hydrochlorothiazide; Hypertension; Male; Methionine; Swine; Swine, Miniature; Vascular Diseases | 1995 |
Methylation in fertilised and parthenogenetic preimplantation mouse embryos.
Topics: Animals; DNA Modification Methylases; Embryo, Mammalian; Embryonic Development; Female; Fertilization; Genomic Imprinting; Homocysteine; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Parthenogenesis; Pregnancy; S-Adenosylmethionine | 1994 |
Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects.
Topics: Adult; Circadian Rhythm; Cysteine; Dietary Proteins; Dipeptides; Fasting; Female; Folic Acid; Food; Homocysteine; Humans; Kinetics; Male; Methionine | 1994 |
Plasma thiols, copper and rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Copper; Cysteine; Glutathione; Homocysteine; Humans; Methionine; Methotrexate; Models, Biological; Sulfhydryl Compounds | 1994 |
Hyperhomocysteinaemia in heart transplant recipients.
Topics: Aged; Coronary Angiography; Coronary Disease; Fasting; Female; Heart Transplantation; Homocysteine; Humans; Male; Methionine; Middle Aged; Postoperative Complications; Renal Insufficiency | 1994 |
Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?
Topics: Adult; Anencephaly; Cystathionine beta-Synthase; Encephalocele; Female; Folic Acid; Homocysteine; Humans; Meningomyelocele; Methionine; Neural Tube Defects; Pregnancy; Pregnancy Complications; Risk Factors | 1994 |
Hyperhomocysteinemia as a possible role for atherosclerosis in CAPD patients.
Topics: Arteriosclerosis; Cysteine; Female; Homocysteine; Humans; Infant, Newborn; Male; Methionine; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Risk Factors | 1994 |
Preoperative methionine loading enhances restoration of the cobalamin-dependent enzyme methionine synthase after nitrous oxide anesthesia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Anesthesia, Inhalation; Female; Homocysteine; Humans; Kinetics; Leukocytes; Male; Methionine; Middle Aged; Nitrous Oxide; Reference Values; Time Factors; Vitamin B 12 | 1994 |
High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.
Topics: Administration, Oral; Adolescent; Adult; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Pedigree; Prevalence; Pulmonary Embolism; Thromboembolism | 1994 |
Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction.
Topics: Adult; Choline; Diet; Folic Acid; Folic Acid Deficiency; Glycine max; Homocysteine; Humans; Male; Methionine; Middle Aged; Nutritional Requirements; Nutritional Status; Vitamin B 12 | 1994 |
Development and reversion of methionine dependence in a human glioma cell line: relation to homocysteine remethylation and cobalamin status.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Brain Neoplasms; Female; Folic Acid; Glioblastoma; Homocysteine; Humans; Methionine; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1994 |
Cobalamin metabolism in cultured human chorionic villus cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Apoenzymes; Biopsy; Cell Division; Cells, Cultured; Chorionic Villi; Homocysteine; Humans; In Vitro Techniques; Methionine; Methylmalonyl-CoA Mutase; Receptors, Cell Surface; Transcobalamins; Vitamin B 12 | 1993 |
Synthesis and transsulfuration of homocysteine in blood.
Topics: Adult; Blood Physiological Phenomena; Blood Platelets; Erythrocytes; Homocysteine; Humans; Leukocytes; Male; Methionine; Serum Albumin, Bovine; Sulfur | 1994 |
Effect of methionine and nitrous oxide on homocysteine export and remethylation in fibroblasts from cystathionine synthase-deficient, cb1G, and cb1E patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Biological Transport, Active; Cell Line; Culture Media; Cystathionine beta-Synthase; Fibroblasts; Homocysteine; Homocystinuria; Humans; Kinetics; Methionine; Methylation; Mutation; Nitrous Oxide | 1994 |
Nitrous oxide degradation by cobalamin-dependent methionine synthase: characterization of the reactants and products in the inactivation reaction.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Electrochemistry; Enzyme Activation; Enzyme Stability; Escherichia coli; Homocysteine; Hydrogen-Ion Concentration; Methionine; Methylation; Nitrous Oxide; Oxidation-Reduction; Oxygen; Spectrophotometry; Vitamin B 12 | 1994 |
Nitrous oxide inactivation of cobalamin-dependent methionine synthase from Escherichia coli: characterization of the damage to the enzyme and prosthetic group.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Sequence; Binding Sites; Electrochemistry; Escherichia coli; Homocysteine; Methionine; Molecular Sequence Data; Nitrous Oxide; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; S-Adenosylmethionine; Tetrahydrofolates; Trypsin; Vitamin B 12 | 1994 |
The case that hyperhomocysteinemia is a risk factor for coronary artery disease.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Coronary Disease; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Risk Factors | 1994 |
Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats.
Topics: Animals; Folic Acid Deficiency; Homocysteine; Kinetics; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Vitamin B 6 Deficiency | 1994 |
[Homocysteinemia as a risk factor for early myocardial infarct--a case-control study].
Topics: Adult; Case-Control Studies; Female; Homocysteine; Humans; Male; Methionine; Myocardial Infarction; Portugal; Risk Factors; Time Factors | 1994 |
Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss.
Topics: Abortion, Habitual; Adult; Amino Acid Metabolism, Inborn Errors; Case-Control Studies; Female; Homocysteine; Humans; Methionine; Middle Aged; Pregnancy; Pregnancy Trimester, First; Prevalence; Risk Factors | 1993 |
Redox status and protein binding of plasma homocysteine and other aminothiols in patients with homocystinuria.
Topics: Adolescent; Adult; Blood Proteins; Child, Preschool; Cysteine; Dipeptides; Female; Homocysteine; Homocystinuria; Humans; Male; Methionine; Oxidation-Reduction; Protein Binding; Regression Analysis | 1993 |
Study on the presence of homocysteine in ovarian follicular fluid.
Topics: Adult; Female; Folic Acid; Follicular Fluid; Homocysteine; Humans; Methionine; Pyridoxine; Reference Values; Vitamin B 12 | 1993 |
Plasma homocysteine in renal failure.
Topics: Adult; Aged; Aged, 80 and over; Creatinine; Female; Glomerular Filtration Rate; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 1993 |
Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Enzyme Activation; Extracellular Space; Fetus; Fibroblasts; Folic Acid; Homocysteine; Humans; Infant; Lung; Male; Methionine; Methylation; Nitrous Oxide; S-Adenosylmethionine | 1993 |
Unchecked DNA synthesis and blocked cell division induced by methionine deprivation in a human prostate cancer cell line.
Topics: Cell Division; Cell Survival; DNA Replication; DNA, Neoplasm; Homocysteine; Humans; Male; Methionine; Prostatic Neoplasms; Tumor Cells, Cultured | 1993 |
Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Cysteine; Female; Homocysteine; Humans; Injections, Intravenous; Kinetics; Male; Methionine | 1993 |
A kinetic study of L-2H3-methyl-1-13C-methionine in patients with severe burn injury.
Topics: Adult; Aged; Burns; Carbon Isotopes; Female; Homocysteine; Humans; Kinetics; Male; Methionine; Middle Aged; Oxidation-Reduction; Radionuclide Imaging; Tritium | 1993 |
Hyperhomocysteinemia in patients operated for lower extremity ischaemia below the age of 50--effect of smoking and extent of disease.
Topics: Adult; Arteriosclerosis; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Ischemia; Male; Methionine; Middle Aged; Postoperative Complications; Pyridoxine; Risk Factors; Smoking; Vitamin B 12 | 1993 |
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aged; Betaine-Homocysteine S-Methyltransferase; Cerebrovascular Disorders; Coronary Disease; Cystathionine beta-Synthase; Female; Homocysteine; Humans; Male; Methionine; Methyltransferases; Middle Aged; Peripheral Vascular Diseases; Vitamins | 1993 |
Energy cost of proofreading in vivo: the charging of methionine tRNAs in Escherichia coli.
Topics: Energy Metabolism; Escherichia coli; Homocysteine; Methionine; Methionine-tRNA Ligase; Protein Biosynthesis; RNA Editing; RNA, Transfer, Met; Substrate Specificity | 1993 |
Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells.
Topics: 3T3 Cells; Animals; Cell Line; CHO Cells; Cricetinae; HeLa Cells; Homocysteine; Humans; Methionine; Methionine-tRNA Ligase; Mice; Mutation; Sulfur Radioisotopes; Temperature; Tumor Cells, Cultured | 1993 |
Hyperhomocysteinemia in retinal artery and retinal vein occlusion.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Male; Methionine; Pyridoxine; Reference Values; Retinal Artery Occlusion; Retinal Vein Occlusion; Smoking; Visual Acuity | 1993 |
Proofreading and the evolution of a methyl donor function. Cyclization of methionine to S-methyl homocysteine thiolactone by Escherichia coli methionyl-tRNA synthetase.
Topics: Acylation; Amino Acid Sequence; Amino Acids; Biological Evolution; Chromatography, Thin Layer; Cyclization; Escherichia coli; Homocysteine; Kinetics; Methionine; Methionine-tRNA Ligase; Methylation; Molecular Sequence Data; Oxidation-Reduction; RNA, Transfer, Met; Safrole; Sequence Homology, Amino Acid | 1993 |
Circulating lipid hydroperoxide levels in human hyperhomocysteinemia. Relevance to development of arteriosclerosis.
Topics: Adult; Arteriosclerosis; Cholesterol Esters; Cystathionine beta-Synthase; Female; Heterozygote; Homocysteine; Humans; Lipoproteins, HDL; Male; Methionine; Peroxides | 1993 |
Homocysteine-dependent demethylation of trimethylselenonium ion and selenobetaine with methionine formation.
Topics: Animals; Betaine; Binding, Competitive; Cytosol; Homocysteine; Homocysteine S-Methyltransferase; Kinetics; Liver; Male; Methionine; Methylation; Methyltransferases; Organoselenium Compounds; Rats; Rats, Sprague-Dawley; Selenium; Selenium Compounds | 1993 |
At least four regulatory genes control sulphur metabolite repression in Aspergillus nidulans.
Topics: Arylsulfatases; Aspergillus nidulans; Carbon-Oxygen Lyases; Chromosome Mapping; Chromosomes, Fungal; Crosses, Genetic; Cysteine Synthase; Genes, Fungal; Genes, Regulator; Genes, Suppressor; Genetic Linkage; Homocysteine; Lyases; Methionine; Multienzyme Complexes; S-Adenosylmethionine; Saccharomyces cerevisiae Proteins; Sulfate Adenylyltransferase; Sulfur | 1993 |
Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease.
Topics: Administration, Oral; Adult; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Homocysteine; Humans; Male; Methionine; Middle Aged; Time Factors | 1996 |
Plasma homocysteine and severity of atherosclerosis in young patients with lower-limb atherosclerotic disease.
Topics: Adult; Arteriosclerosis; Cerebrovascular Disorders; Coronary Disease; Fasting; Female; Folic Acid; Homocysteine; Humans; Leg; Male; Methionine; Middle Aged; Pyridoxine; Risk Factors; Vitamin B 12 | 1996 |
Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Folic Acid Deficiency; Half-Life; Hematinics; Homocysteine; Humans; Kinetics; Male; Methionine; Methylmalonic Acid; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1996 |
Elevated plasma concentration of reduced homocysteine in patients with human immunodeficiency virus infection.
Topics: Adult; CD4 Lymphocyte Count; Cysteine; Dipeptides; Female; Folic Acid; HIV Antibodies; HIV Infections; HIV-1; Homocysteine; Humans; Interleukin-2; Lymphocytes; Male; Methionine; Middle Aged; Oxidation-Reduction; Oxidative Stress; Vitamin B 12 | 1996 |
Plasma homocysteine and menopausal status.
Topics: Adult; Aged; Estradiol; Female; Homocysteine; Humans; Methionine; Middle Aged; Postmenopause; Premenopause; Vitamins | 1995 |
Liver DNA and RNA metabolism in rats fed diets lacking methionine plus cysteine with or without restricted energy.
Topics: Animal Feed; Animals; Body Weight; Cell Nucleus; Cell Size; Cystathionine; Cysteine; Deoxyribonucleases; Diet; DNA; Eating; Energy Metabolism; Homocysteine; Liver; Male; Methionine; Methylation; Organ Size; Proteins; Rats; Rats, Wistar; Ribonucleases; RNA; Solubility | 1995 |
Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.
Topics: Case-Control Studies; Diet; Diet Surveys; Fasting; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Methionine; Methylation; Middle Aged; Myocardial Infarction; Odds Ratio; Pyridoxine; Risk Factors; Vitamin B 12 | 1996 |
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Administration, Oral; Analysis of Variance; Animal Feed; Animals; Apoptosis; Cell Division; Deoxyuracil Nucleotides; Ethanol; Folic Acid; Homocysteine; Liver; Male; Methionine; Proliferating Cell Nuclear Antigen; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Thymine Nucleotides | 1996 |
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Evaluation of the presence of premature atherosclerosis in adults with heterozygosity for cystathionine-beta-synthase deficiency.
Topics: Adolescent; Adult; Arteriosclerosis; Blood Circulation; Carotid Stenosis; Cerebral Arterial Diseases; Coronary Artery Disease; Cystathionine beta-Synthase; Female; Femoral Artery; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Peripheral Vascular Diseases; Tunica Intima; Tunica Media | 1996 |
The synthetic/editing active site of an aminoacyl-tRNA synthetase: evidence for binding of thiols in the editing subsite.
Topics: Binding Sites; Cysteine; Escherichia coli; Homocysteine; Kinetics; Methionine; Methionine-tRNA Ligase; Models, Chemical; Recombinant Proteins; Substrate Specificity; Sulfhydryl Compounds | 1996 |
The effect of a subnormal vitamin B-6 status on homocysteine metabolism.
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Cystathionine; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Pyridoxine; Theophylline; Vitamin B 6 Deficiency | 1996 |
Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.
Topics: Animals; Carotid Arteries; Choline Deficiency; Cross-Over Studies; Diet; Extremities; Folic Acid Deficiency; Homocysteine; Homocystine; Macaca fascicularis; Methionine; Protein C; Random Allocation; Regional Blood Flow; Thrombomodulin; Vascular Diseases; Vascular Resistance; Vasomotor System | 1996 |
Homocysteinaemia after methionine overload as a coronary artery disease risk factor: importance of age and homocysteine levels.
Topics: Age Factors; Case-Control Studies; Coronary Disease; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Odds Ratio; Risk Factors | 1995 |
Molecular and biochemical approaches in the identification of heterozygotes for homocystinuria.
Topics: Adolescent; Adult; Base Sequence; Biochemistry; Cystathionine beta-Synthase; DNA Mutational Analysis; Female; Genetic Carrier Screening; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Molecular Biology; Molecular Probes; Molecular Sequence Data; Pyridoxine | 1996 |
Hepatic betaine-homocysteine methyltransferase activity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine.
Topics: Amino Acids, Sulfur; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Chickens; Choline; Cystine; Diet; Dose-Response Relationship, Drug; Female; Homocysteine; Liver; Male; Methionine; Methyltransferases; Random Allocation | 1996 |
Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine.
Topics: Angiotensin II; Animals; Aorta; Arteriosclerosis; Cholestanols; Cholesterol; Cholic Acid; Cholic Acids; Endothelium, Vascular; Homocysteine; Hypertension; Hypolipidemic Agents; Male; Methionine; Methylthiouracil; Microscopy, Electron; Mitochondria; Rats; Rats, Inbred SHR; Rats, Wistar; Tunica Intima; Vasoconstrictor Agents | 1996 |
Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy humans.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Kinetics; Male; Methionine; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1996 |
The importance of transmethylation reactions to methionine metabolism in sheep: effects of supplementation with creatine and choline.
Topics: Animals; Choline; Creatine; Homocysteine; Methionine; Methylation; Sheep; Wool | 1996 |
Hyperhomocysteinemia as a risk factor for deep-vein thrombosis.
Topics: Fasting; Homocysteine; Homocystine; Humans; Methionine; Risk Factors; Thrombophlebitis | 1996 |
Long term treatment with betaine in methylenetetrahydrofolate reductase deficiency.
Topics: Appetite; Betaine; Female; Follow-Up Studies; Growth; Homocysteine; Humans; Infant; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors | 1996 |
Homocysteine response to methionine challenge in four obligate heterozygotes for homocystinuria and relationship with cystathionine beta-synthase mutations.
Topics: Adolescent; Adult; Cystathionine beta-Synthase; Female; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Mutation | 1996 |
Hyperhomocysteinemia induced by folic acid deficiency and methionine load--applications of a modified HPLC method.
Topics: Adult; Animals; Arteriosclerosis; Chromatography, High Pressure Liquid; Cricetinae; Cysteine; Female; Folic Acid Deficiency; Glutathione; Homocysteine; Humans; Male; Methionine; Middle Aged; Rats; Sensitivity and Specificity | 1996 |
Prevalence of familial mild hyperhomocysteinemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cardiovascular Diseases; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Pedigree | 1996 |
Variability of the methionine loading test: no effect of a low protein diet.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Dietary Proteins; Female; Homocysteine; Humans; Male; Methionine; Middle Aged | 1996 |
Homocyst(e)ine is bad for blood vessels, but how come?
Topics: Arteriosclerosis; Blood Vessels; Cardiovascular Diseases; Cysteine; Homocysteine; Homocystine; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Methionine; Risk Factors | 1996 |
Susceptibility of plasma low- and high-density lipoproteins to oxidation in patients with severe hyperhomocysteinemia.
Topics: Adolescent; Child; Child, Preschool; Cholesterol; Cysteine; Female; Homocysteine; Humans; Kinetics; Lipoprotein(a); Lipoproteins, HDL; Lipoproteins, LDL; Male; Methionine; Oxidation-Reduction; Serum Albumin; Thiobarbituric Acid Reactive Substances; Triglycerides | 1996 |
[The prevalence of hyperhomocysteinemia in thromboangiitis obliterans. Does homocysteine play a role pathogenetically?].
Topics: Adult; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Prevalence; Pyridoxine; Risk Factors; Smoking; Statistics, Nonparametric; Thromboangiitis Obliterans; Time Factors; Vitamin B 12 | 1996 |
The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine.
Topics: Adolescent; Adult; Aged; Diet; Endotoxins; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Reference Values | 1996 |
Maternal and fetal levels of methionine and homocysteine in early human pregnancy.
Topics: Amniotic Fluid; Cross-Sectional Studies; Female; Fetus; Gestational Age; Homocysteine; Humans; Methionine; Pregnancy; Pregnancy Trimester, First | 1997 |
Plasma homocysteine and methionine concentrations in children with neural tube defects.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Homocysteine; Humans; Infant; Male; Meningomyelocele; Methionine; Reference Values | 1996 |
Vitamin B-6 normalizes the altered sulfur amino acid status of rats fed diets containing pharmacological levels of niacin without reducing niacin's hypolipidemic effects.
Topics: Animals; Cysteine; Diet; Homocysteine; Lipids; Male; Methionine; Niacin; Pyridoxine; Rats; Rats, Sprague-Dawley | 1997 |
[Basal homocysteinemia or following a methionine load. Which is the better indicator of coronary disease risk?].
Topics: Case-Control Studies; Coronary Disease; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Odds Ratio; Risk Factors; Time Factors | 1996 |
Translational fidelity of methionyl-tRNA synthetase.
Topics: Animals; Carbon Radioisotopes; Cell-Free System; Homocysteine; Liver; Methionine; Methionine-tRNA Ligase; Protein Biosynthesis; Rabbits; Rats; Reticulocytes; RNA, Transfer; Substrate Specificity; Sulfur Radioisotopes | 1997 |
Methionine deprivation and methionine analogs inhibit cell proliferation and growth of human xenografted gliomas.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Glioma; Growth Inhibitors; Homocysteine; Humans; Methionine; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous | 1997 |
Mild hyperhomocysteinemia and hemostatic factors in patients with arterial vascular diseases.
Topics: Adult; Analysis of Variance; Arterial Occlusive Diseases; Arteriosclerosis; Blood Chemical Analysis; Blood Coagulation; Female; Fibrinolysis; Hemostasis; Homocysteine; Humans; Male; Methionine; Middle Aged; Nitric Oxide; Vitamins | 1997 |
Fasting and post-methionine homocyst(e)ine levels in a healthy Australian population.
Topics: Adult; Aged; Australia; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Reference Values; Vitamin B 12 | 1997 |
Abnormal homocysteine metabolism in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Fasting; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
beta-Adrenergic stimulation promotes homocysteic acid release from astrocyte cultures: evidence for a role of astrocytes in the modulation of synaptic transmission.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Astrocytes; Atenolol; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Cysteine; Diffusion Chambers, Culture; Homocysteine; Isoproterenol; Methionine; Methoxamine; Mice; Norepinephrine; Synaptic Transmission | 1997 |
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.
Topics: Adult; Arteriosclerosis; Blood Chemical Analysis; Case-Control Studies; Fasting; Female; Homocysteine; Humans; Hypercholesterolemia; Hypertension; Logistic Models; Male; Methionine; Middle Aged; Risk Factors; Smoking; Vascular Diseases | 1997 |
Growth of methionine-dependent human prostate cancer (PC-3) is inhibited by ethionine combined with methionine starvation.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Cycle; Cell Division; Ethionine; Homocysteine; Humans; Male; Methionine; Mice; Neoplasm Transplantation; Prostatic Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured | 1997 |
Total plasma homocysteine determination by liquid chromatography before and after methionine loading. Results in cerebrovascular disease.
Topics: Adult; Cerebrovascular Disorders; Chromatography, Ion Exchange; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged | 1997 |
Cyanocobalamin [c-lactam] inhibits vitamin B12 and causes cytotoxicity in HL60 cells: methionine protects cells completely.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Death; Enzyme Inhibitors; Folic Acid; HL-60 Cells; Homocysteine; Humans; Hydroxocobalamin; Methionine; Methylmalonyl-CoA Mutase; Propionates; Tetrahydrofolates; Vitamin B 12 | 1997 |
Effects of methylcobalamin on the proliferation of androgen-sensitive or estrogen-sensitive malignant cells in culture and in vivo.
Topics: Androgens; Animals; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estrogens; Female; Homocysteine; Humans; Leydig Cell Tumor; Male; Mammary Neoplasms, Animal; Methionine; Mice; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Testicular Neoplasms; Tumor Cells, Cultured; Vitamin B 12 | 1997 |
Carbon-11 labeled ethionine and propionine as tumor detecting agents.
Topics: Animals; Biological Transport, Active; Butyrates; Carbon Radioisotopes; Cycloheximide; Ethionine; Female; Homocysteine; Mammary Neoplasms, Experimental; Methionine; Mice; Pilot Projects; Protein Synthesis Inhibitors; Tissue Distribution; Tomography, Emission-Computed | 1997 |
Response of the methionine synthase system to short-term culture with homocysteine and nitrous oxide and its relation to methionine dependence.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analgesics, Non-Narcotic; Glioma; Homocysteine; Humans; Methionine; Nitrous Oxide; Tumor Cells, Cultured | 1997 |
The 677C-->T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease.
Topics: Adult; Aged; Alcohol Drinking; Case-Control Studies; Comorbidity; Coronary Artery Disease; Disease Susceptibility; Erythrocytes; Fasting; Female; Folic Acid; Genes; Genotype; Homocysteine; Humans; Hyperlipidemias; Hypertension; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Obesity; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Risk Factors; Smoking | 1997 |
Methionine synthase from pig liver.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Radioisotopes; Chromatography; Chromatography, Gel; Homocysteine; Hydrogen-Ion Concentration; Liver; Methionine; Molecular Weight; Spectrophotometry; Swine; Tetrahydrofolates | 1997 |
Purification and assay of cobalamin-dependent methionine synthase from Escherichia coli.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Carbon Radioisotopes; Escherichia coli; Homocysteine; Methionine; Spectrophotometry; Tetrahydrofolates; Vitamin B 12 | 1997 |
Gender differences and other determinants of the rise in plasma homocysteine after L-methionine loading.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arteriosclerosis; Creatinine; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Reference Values; Risk Factors; Sex Characteristics | 1997 |
Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Administration, Oral; Adult; Female; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1997 |
Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kinetics; Male; Methionine; Middle Aged | 1997 |
Hyperhomocysteinemia following oral methionine load is associated with increased lipid peroxidation.
Topics: Adult; Female; Homocysteine; Humans; Lipid Peroxidation; Male; Methionine | 1997 |
Nerve growth factor-specific regulation of protein methylation during neuronal differentiation of PC12 cells.
Topics: Adenosine; Animals; Cell Differentiation; Cell-Free System; DNA Methylation; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Homocysteine; Kinetics; Methionine; Methylation; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Processing, Post-Translational; Rats; S-Adenosylmethionine; Signal Transduction; Tritium | 1997 |
Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells.
Topics: Adult; Aged; Ascitic Fluid; Cysteine; Female; Folic Acid; Glycine; Homocysteine; Humans; Methionine; Methylation; Middle Aged; Ovarian Neoplasms; Vitamin B 12 | 1997 |
Oxidative stress in diabetic macrovascular disease: does homocysteine play a role?
Topics: Adult; Analysis of Variance; Brain Ischemia; Carotid Artery Diseases; Case-Control Studies; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Free Radicals; Homocysteine; Humans; Hypoglycemic Agents; Insulin; Lipid Peroxidation; Male; Methionine; Middle Aged; Oxidative Stress; Peripheral Vascular Diseases; Sulfonylurea Compounds; Thiobarbiturates | 1997 |
Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.
Topics: Adult; Cystathionine; Fatigue Syndrome, Chronic; Female; Fibromyalgia; Homocysteine; Humans; Methionine; Middle Aged; Models, Biological; Vitamin B 12 | 1997 |
Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipients.
Topics: Adult; Aged; Arteriosclerosis; Fasting; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Methionine; Middle Aged; Pyridoxine | 1997 |
A novel pathway for the conversion of homocysteine to methionine in eukaryotes.
Topics: Animals; Homocysteine; Hydrogen-Ion Concentration; Hydrolysis; Liver; Methionine; Methionine-tRNA Ligase; Multienzyme Complexes; Rabbits; RNA, Transfer, Met; Sheep | 1997 |
Low concentrations of folate in serum and erythrocytes of smokers: methionine loading decreases folate concentrations in serum of smokers and nonsmokers.
Topics: Adult; Cysteine; Dipeptides; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Smoking | 1997 |
Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats.
Topics: Adenosine Diphosphate; Amino Acids; Analysis of Variance; Animals; Blood Platelets; Diet; Folic Acid Deficiency; Glutathione; Homocysteine; Lipid Peroxidation; Macrophages, Peritoneal; Male; Malondialdehyde; Methionine; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Regression Analysis; Thiobarbituric Acid Reactive Substances; Thrombin; Thromboplastin; Thromboxanes | 1997 |
Total, free, and protein-bound sulphur amino acids in uraemic patients.
Topics: Adult; Cysteine; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Protein Binding; Renal Dialysis; Taurine; Uremia | 1997 |
[Blood levels of homocysteine in patients under 55 years of age with acute coronary insufficiency].
Topics: Acute Disease; Adult; Coronary Disease; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Reproducibility of Results; Risk Factors | 1997 |
Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM.
Topics: Administration, Oral; Adult; Albuminuria; Case-Control Studies; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Nephropathies; Endothelium, Vascular; Female; Homocysteine; Homocystine; Humans; Male; Methionine; Middle Aged; Reference Values; Thrombomodulin | 1997 |
High prevalence of hyperhomocysteinemia and asymptomatic vascular disease in siblings of young patients with vascular disease and hyperhomocysteinemia.
Topics: Adult; Blood Pressure; Carotid Stenosis; Diabetes Mellitus; Disease Susceptibility; Echocardiography; Exercise Test; Fasting; Female; Homocysteine; Humans; Hypercholesterolemia; Hypertension; Male; Mass Screening; Methionine; Middle Aged; Multivariate Analysis; Nuclear Family; Prevalence; Risk Factors; Single-Blind Method; Smoking; Vascular Diseases | 1997 |
Effect of long-term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Carbon-Sulfur Lyases; Cysteine; Diet; Glutathione; Homocysteine; Humans; Liver; Medulloblastoma; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Time Factors; Transplantation, Heterologous | 1997 |
Reference range for % rise in homocysteine after oral methionine load.
Topics: Adult; Aged; Australia; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Reference Values | 1997 |
Adding methionine to every paracetamol tablet. Plan is needed for way in which paracetamol and other analgesics are sold.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Drug Combinations; Drug Industry; Drug Overdose; Health Planning; Homocysteine; Humans; Methionine | 1998 |
Homocysteinemia and endothelial damage after methionine load.
Topics: Arterial Occlusive Diseases; Blood Cell Count; Blood Cells; Endothelium, Vascular; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Peripheral Vascular Diseases | 1997 |
Simplified simultaneous assay of total plasma homocysteine and methionine by HPLC and pulsed integrated amperometry.
Topics: Chromatography, High Pressure Liquid; Electricity; Homocysteine; Humans; Methionine | 1998 |
[Influence of levels of vitamin B2, B12, and folic acid on the values of basal homocysteinemia and after methionine overload].
Topics: Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Pyridoxine; Vitamin B 12 | 1998 |
[Homocysteinemia as a risk factor for vascular disease-which patients should be treated?].
Topics: Homocysteine; Humans; Methionine; Middle Aged; Odds Ratio; Risk Factors; Vascular Diseases | 1998 |
Methylenetetrahydrofolate reductase deficiency in a patient with phenotypic findings of Angelman syndrome.
Topics: Angelman Syndrome; Child; Diagnosis, Differential; Homocysteine; Homocystinuria; Humans; Male; Metabolism, Inborn Errors; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Phenotype; Vitamin B 12 | 1998 |
Effect of homocysteine and cholesterol in raising plasma homocysteine, cholesterol and triglyceride levels.
Topics: Animals; Cholesterol; Cholesterol, Dietary; Drug Combinations; Drug Synergism; Homocysteine; Methionine; Rats; Rats, Inbred WKY; Triglycerides | 1998 |
Neural-tube defects are associated with low concentrations of cobalamin (vitamin B12) in amniotic fluid.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amniocentesis; Amniotic Fluid; Case-Control Studies; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Methionine; Methylation; Neural Tube Defects; Pilot Projects; Pregnancy; Reference Values; Vitamin B 12 | 1998 |
Methionine loading test is necessary for detection of hyperhomocysteinemia.
Topics: Adult; Arteriosclerosis; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Risk Factors; Thrombophlebitis | 1998 |
Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine.
Topics: Adult; Aged; Aged, 80 and over; Fasting; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Pyridoxine; Reference Values | 1998 |
Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta.
Topics: Amino Acid Sequence; Annexin A2; Base Sequence; Cells, Cultured; Cycloheximide; Cystathionine beta-Synthase; Endothelium, Vascular; Gene Expression Regulation; Homocysteine; Humans; Methionine; Molecular Sequence Data; Muscle, Smooth, Vascular; Oxidative Stress; Peptide Elongation Factor 1; Peptide Elongation Factors; Protein Biosynthesis; RNA, Messenger; Sulfhydryl Compounds; Transcription, Genetic | 1998 |
Functionally null mutations in patients with the cblG-variant form of methionine synthase deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line; Child; Cloning, Molecular; Codon, Terminator; DNA, Complementary; Female; Fibroblasts; Frameshift Mutation; Genetic Complementation Test; Genetic Variation; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Introns; Male; Methionine; Nuclear Family; Polymorphism, Single-Stranded Conformational; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin; Transcription, Genetic; Vitamin B 12 | 1998 |
Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Feedback; Glioma; Homocysteine; Humans; Methionine; Microsomes; Mitochondria; Nitrous Oxide; Receptors, Cell Surface; Tumor Cells, Cultured; Vitamin B 12 | 1998 |
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Anticonvulsants; Female; Folic Acid; Glutathione; Homocysteine; Liver; Methionine; Mice; Neural Tube Defects; Pregnancy; Valproic Acid | 1998 |
A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men.
Topics: Adult; Aged; Alleles; Case-Control Studies; Confidence Intervals; Coronary Disease; Diet; Folic Acid; Follow-Up Studies; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Riboflavin; Risk Factors; Smoking; United States; Vitamin B 12 | 1998 |
Fasting and post-methionine load homocyst(e)ine values are correlated with microalbuminuria and could contribute to worsening vascular damage in non-insulin-dependent diabetes mellitus patients.
Topics: Aged; Albuminuria; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged | 1998 |
The relationship between plasma homocysteine and amino acid concentrations in patients with end-stage renal disease.
Topics: Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Essential; Cross-Sectional Studies; Cysteine; Female; Histidine; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Reference Values | 1998 |
Ability of endogenous folate from soy protein isolate to maintain plasma homocysteine and hepatic DNA methylation during methyl group depletion in rats.
Topics: 5-Methylcytosine; Animals; Caseins; Choline Deficiency; Cytosine; Dietary Proteins; DNA; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley; Soybean Proteins; Weaning | 1998 |
Methionine ligation strategy in the biomimetic synthesis of parathyroid hormones.
Topics: Amides; Chromatography, High Pressure Liquid; Esterification; Homocysteine; Mass Spectrometry; Methionine; Methylation; Parathyroid Hormone; Peptides; Protein Engineering; Protein Splicing | 1998 |
High expression, purification, and properties of recombinant homocysteine alpha, gamma-lyase.
Topics: Animals; Carbon-Sulfur Lyases; Cardiovascular Diseases; Chromatography; Cloning, Molecular; Cysteine; Enzyme Stability; Escherichia coli; Homocysteine; Hydrogen-Ion Concentration; Hyperhomocysteinemia; Kinetics; Methionine; Protein Conformation; Protozoan Proteins; Pseudomonas putida; Pyridoxal Phosphate; Recombinant Proteins; Substrate Specificity; Temperature; Trichomonas vaginalis | 1998 |
Augmented effects of methionine and cholesterol in decreasing the elastic lamina while thickening the aortic wall in the rat aorta.
Topics: Analysis of Variance; Animals; Aorta; Cardiovascular Diseases; Cholesterol; Diet; Drug Synergism; Elastic Tissue; Homocysteine; Methionine; Rats; Rats, Inbred WKY | 1998 |
Homozygous G20210A prothrombin gene mutation without thromboembolic events: a case report.
Topics: 3' Untranslated Regions; Adult; Aged; Brain Ischemia; Female; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; Male; Methionine; Middle Aged; Prothrombin; Risk Factors; Thrombophilia; Thrombophlebitis | 1998 |
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methionine; Methylation; Phosphatidylcholines; S-Adenosylmethionine; Seizures; Serine; Tetrahydrofolates | 1998 |
Synthesis of beta-difluorine-containing amino acids.
Topics: Amino Acids; Ascorbic Acid; Drug Design; Homocysteine; Homoserine; Indicators and Reagents; Methionine; Molecular Structure; Structure-Activity Relationship | 1998 |
Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects.
Topics: Adult; Black People; DNA; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Neural Tube Defects; Nutritional Status; Pregnancy; Pregnancy Complications; Rural Population; South Africa | 1999 |
Is the oral methionine loading test insensitive to the remethylation pathway of homocysteine?
Topics: Artifacts; Folic Acid Deficiency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Reproducibility of Results; Risk Factors; Thrombophilia | 1999 |
Influences of supplementary dietary tungsten on methionine metabolism in rabbits fed a low-cholesterol plus methionine diet.
Topics: 2,3-Diphosphoglycerate; Animals; Body Weight; Cholesterol; Diet, Fat-Restricted; Dietary Supplements; Erythrocytes; Glutathione; Homocysteine; Male; Methionine; Rabbits; Sulfates; Taurine; Triglycerides; Tungsten | 1998 |
Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation.
Topics: Analysis of Variance; Animals; Female; Folic Acid; Gestational Age; Homocysteine; Methionine; Methylation; Rats; Rats, Wistar; Valproic Acid | 1999 |
Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Age of Onset; Coronary Disease; Cystathionine beta-Synthase; Fasting; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic | 1999 |
Combination of low-dose folic acid and pyridoxine for treatment of hyperhomocysteinaemia in patients with premature arterial disease and their relatives.
Topics: Adult; Age of Onset; Arteriosclerosis; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Prospective Studies; Pyridoxine; Risk Factors | 1999 |
The protein phosphatase inhibitor cantharidin induces head and foot formation in buds of Cassiopea andromeda (Rhizostomae, Scyphozoa).
Topics: Alkaloids; Animals; Cantharidin; Cnidaria; Cycloleucine; Enzyme Inhibitors; Extremities; Head; Homocysteine; Methionine; Niacin; Phosphoprotein Phosphatases; Regeneration; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
[The effect of sex and menopause on basal blood levels of homocysteine and after methionine loading].
Topics: Administration, Oral; Adult; Female; Homocysteine; Humans; Male; Menopause; Methionine; Middle Aged; Patient Selection; Reference Values; Sex Characteristics; Statistics, Nonparametric | 1999 |
Hyperhomocysteinemia and hypofibrinolysis in young adults with ischemic stroke.
Topics: Adolescent; Adult; Brain Ischemia; Case-Control Studies; Cerebral Arteries; Cerebrovascular Disorders; Female; Fibrinolysis; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Dehydrogenase (NAD+); Mutation; Oxidoreductases; Risk Factors; Vitamins | 1999 |
Methionine infusion reproduces liver injury of parenteral nutrition cholestasis.
Topics: Amino Acids; Animals; Bile; Cholestasis; Cysteine; Homocysteine; Humans; Infant; Infusions, Intravenous; Liver; Methionine; Parenteral Nutrition, Total; Rabbits | 1999 |
Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease.
Topics: Adult; Age Factors; Amino Acid Substitution; Arteriosclerosis; Body Mass Index; Comorbidity; Fasting; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Lipids; Male; Menopause; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pyridoxine; Smoking; Vitamin B 12 | 1999 |
Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and cardiovascular disease.
Topics: Administration, Oral; Adult; Aged; Albuminuria; Analysis of Variance; Blood Pressure; Cardiovascular Diseases; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Postmenopause; Premenopause; Pyridoxal Phosphate; Regression Analysis; Risk Factors; Vitamin B 12 | 1999 |
[Obstetric problems followed by stroke].
Topics: Abortion, Habitual; Adult; Arteriosclerosis; Cerebral Infarction; Diagnosis, Differential; Female; Fetal Death; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Male; Methionine; Nutrition Disorders; Placental Insufficiency; Pregnancy; Pregnancy Complications, Cardiovascular; Pyridoxine; Smoking; Venous Thrombosis; Vitamin B 6 Deficiency | 1999 |
Nutritional hyperhomocysteinaemia.
Topics: Diet; Homocysteine; Humans; Methionine; Vascular Diseases | 1999 |
Methionine loading in a Down's syndrome patient with cerebral infarction.
Topics: Adult; Cerebral Infarction; Down Syndrome; Homocysteine; Humans; Male; Methionine; Thiobarbituric Acid Reactive Substances | 1999 |
Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase.
Topics: Acylation; Adenosine Triphosphate; Alanine; Amino Acids; Cysteine; Escherichia coli; Homocysteine; Hydrolysis; Lactams; Leucine; Lysine-tRNA Ligase; Methionine; Ornithine; RNA Editing; RNA, Transfer, Lys; Threonine | 1999 |
Fasting, postprandial, and post-methionine-load homocysteinaemia and methylenetetrahydrofolate reductase polymorphism in vascular disease.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Fasting; Female; Heterozygote; Homocysteine; Homozygote; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Postprandial Period | 1999 |
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Amino Acid Substitution; Child; Child, Preschool; Deoxyribonucleases, Type II Site-Specific; DNA; Family Health; Female; Gene Frequency; Genetic Variation; Genotype; Homocysteine; Humans; Isoleucine; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Regression Analysis; Risk Factors; Spinal Dysraphism; Vitamin B 12 | 1999 |
Relation between plasma homocysteine concentration, the 844ins68 variant of the cystathionine beta-synthase gene, and pyridoxal-5'-phosphate concentration.
Topics: Adult; Aged; Cystathionine beta-Synthase; Fasting; Female; Genetic Variation; Genotype; Homocysteine; Humans; Male; Methionine; Middle Aged; Mutagenesis, Insertional; Pyridoxal Phosphate | 1999 |
Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia.
Topics: Acetylcholine; Animals; Arterioles; Arteriosclerosis; Diet; Histamine; Homocysteine; In Vitro Techniques; Male; Methionine; Nitric Oxide; Nitroprusside; Norepinephrine; Rats; Rats, Wistar; Vascular Resistance; Vasodilator Agents | 1999 |
Short-term reproducibility of total homocysteine determinations in stable renal transplant recipients.
Topics: Adult; Aged; Cholesterol; Female; Homocysteine; Humans; Kidney Transplantation; Male; Methionine; Middle Aged; Reproducibility of Results | 1999 |
Homocysteine and methionine metabolism in ESRD: A stable isotope study.
Topics: Adult; Aged; Carbon Isotopes; Cardiovascular Diseases; Case-Control Studies; Deuterium; Female; Homocysteine; Humans; Kidney Failure, Chronic; Kinetics; Male; Methionine; Methylation; Middle Aged; Renal Dialysis; Risk Factors | 1999 |
Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans.
Topics: Acetylcholine; Adult; Antioxidants; Ascorbic Acid; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroprusside; Oxidative Stress; Vasodilation; Vasodilator Agents; Verapamil | 1999 |
Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; DNA Mutational Analysis; DNA, Complementary; Enzyme Activation; Ferredoxin-NADP Reductase; Folic Acid; Genes, Recessive; Genetic Complementation Test; Heteroduplex Analysis; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Mutation; Polymorphism, Single-Stranded Conformational; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing; Sequence Analysis, DNA; Vitamin B 12 | 1999 |
Influence of homocysteine on matrix metalloproteinase-2: activation and activity.
Topics: Cysteine; Enzyme Activation; Enzyme Precursors; Gelatin; Gelatinases; Glutathione; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Matrix Metalloproteinase 2; Metalloendopeptidases; Methionine | 1999 |
Addition of arginine but not glycine to lysine plus methionine-enriched diets modulates serum cholesterol and liver phospholipids in rabbits.
Topics: Amino Acids; Analysis of Variance; Animals; Arginine; Body Weight; Cholesterol; Diet; Drug Interactions; Glycine; Homocysteine; Hypercholesterolemia; Lipoproteins; Liver; Lysine; Male; Methionine; Phospholipids; Rabbits | 1999 |
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
Topics: Adult; Alcohol Drinking; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyribonucleases, Type II Site-Specific; Diet Surveys; Diet, Reducing; Dietary Supplements; DNA; Down Syndrome; Electrophoresis, Agar Gel; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Risk Factors; Surveys and Questionnaires | 1999 |
Cysteine biosynthesis in Saccharomyces cerevisiae: a new outlook on pathway and regulation.
Topics: Biological Transport; Cystathionine gamma-Lyase; Cysteine; Homocysteine; Methionine; Saccharomyces cerevisiae; Sulfates | 1999 |
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia.
Topics: Adult; Case-Control Studies; Child, Preschool; Cleft Lip; Cleft Palate; Erythrocytes; Fasting; Female; Folic Acid; Homocysteine; Humans; Infant; Maternal-Fetal Exchange; Methionine; Pregnancy; Pyridoxine; Risk Factors; Vitamin B 12 | 1999 |
Familial hyperhomocysteinaemia and endothelium-dependent vasodilatation and arterial distensibility of large arteries.
Topics: Adult; Brachial Artery; Carotid Artery, Common; Endothelium, Vascular; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Regional Blood Flow; Regression Analysis; Vascular Diseases; Vasodilation | 1999 |
The effect of diet on plasma homocysteine concentrations in healthy male subjects.
Topics: Adult; Cross-Sectional Studies; Diet; Diet, Vegetarian; Fasting; Folic Acid; Homocysteine; Humans; Male; Meat; Methionine; Methylation; Middle Aged; Vitamin B 12 | 1999 |
[Gender differences in serum homocysteine levels and associated factors].
Topics: Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Sex Characteristics; Vitamin B 12 | 1999 |
Evidence of altered homocysteine metabolism in chronic renal failure.
Topics: Arteriosclerosis; Citrates; Creatinine; Cystathionine; Cysteine; Female; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Methylmalonic Acid; Middle Aged; Renal Dialysis; Risk Factors; Vitamins | 1999 |
Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia.
Topics: Administration, Oral; Adult; Blood Flow Velocity; Drug Therapy, Combination; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxine; Treatment Outcome; Vasodilation; Vitamin B 12 | 1999 |
The effect of estrogen replacement therapy on total plasma homocysteine in healthy postmenopausal women.
Topics: Adult; Estrogen Replacement Therapy; Folic Acid; Homocysteine; Humans; Linear Models; Lipids; Methionine; Middle Aged; Postmenopause; Pyridoxine; Reference Values; Time Factors; Vitamin B 12 | 2000 |
Sulfur-containing amino acids decrease cisplatin cytotoxicity and uptake in renal tubule epithelial cell lines.
Topics: Acetylcysteine; Amino Acids; Animals; Antineoplastic Agents; Cisplatin; Cysteine; Homocysteine; Humans; Kidney Tubules; Methionine; Mice; Tumor Cells, Cultured | 2000 |
Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults.
Topics: Adult; Aged; Aging; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Oxidation-Reduction; Prospective Studies; Vasodilation | 2000 |
[Levels of total plasma homocysteine after methionine intake in a group of healthy subjects in Northern + Italy. Relationship with age, gender, and nutritional status].
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Female; Homocysteine; Humans; Italy; Male; Methionine; Middle Aged; Nutritional Status; Sex Factors | 1999 |
Methionine depletion enhances the antitumoral efficacy of cytotoxic agents in drug-resistant human tumor xenografts.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Brain Neoplasms; Carcinoma, Small Cell; Cell Division; Colonic Neoplasms; Dietary Supplements; Drug Resistance, Multiple; Ethionine; Female; Genes, MDR; Glioma; Glutathione; Homocysteine; Humans; Lung Neoplasms; Male; Methionine; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Neoplasms; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss.
Topics: Abortion, Habitual; Adult; Blood Vessels; Chorion; Female; Gestational Age; Homocysteine; Humans; Methionine; Pregnancy | 2000 |
Homocysteine thiolactone is a positive effector of sigma(S) levels in Escherichia coli.
Topics: Bacterial Proteins; Culture Media; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Homocysteine; Methionine; Repressor Proteins; Sigma Factor; Vitamin B 12 | 2000 |
[Should we consider hyperhomocysteinemia as a vascular risk factor?].
Topics: Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Polymorphism, Genetic; Risk Factors; Thrombosis; Vitamin B Complex | 2000 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2000 |
Determination of isotopic enrichments of [1-13C]homocysteine, [1-13C]methionine and [2H3-methyl-1-13C]methionine in human plasma by gas chromatography-negative chemical ionization mass spectrometry.
Topics: Carbon Isotopes; Deuterium; Drug Stability; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Kinetics; Methionine; Methylation; Quality Control; Sensitivity and Specificity | 2000 |
Relationship between homocysteine and superoxide dismutase in homocystinuria: possible relevance to cardiovascular risk.
Topics: Adolescent; Adult; Cardiovascular Diseases; Child; Cystathionine beta-Synthase; Female; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Oxidative Stress; Risk Factors; Superoxide Dismutase | 2000 |
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
Topics: Animals; Arginine; Cell Line, Transformed; Cholesterol; Diet; Dietary Fats; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Macaca fascicularis; Methionine; Nitric Oxide Synthase; Regression Analysis; Vasodilation | 2000 |
Sex-related differences in methionine metabolism and plasma homocysteine concentrations.
Topics: Absorptiometry, Photon; Adult; Breath Tests; Cardiovascular Diseases; Female; Homocysteine; Humans; Male; Methionine; Methylation; Premenopause; Reference Values; Sex Characteristics | 2000 |
[Influence of smoking on homocysteinemia at baseline and after methionine load].
Topics: Adult; Cardiovascular Diseases; Female; Homocysteine; Humans; Male; Methionine; Pyridoxine; Risk Factors; Smoking | 2000 |
Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosis.
Topics: Arteriosclerosis; Cells, Cultured; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Infant, Newborn; Lipoproteins, HDL; Methionine; Proteins | 2000 |
Impaired glucose tolerance (IGT) is not associated with disturbed homocysteine metabolism.
Topics: Blood Glucose; Cardiovascular Diseases; Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fasting; Folic Acid; Homocysteine; Humans; Insulin; Male; Methionine; Middle Aged; Proinsulin; Risk Factors; Time Factors; Vitamin B 12 | 2000 |
Methionine transamination in patients with homocystinuria due to cystathionine beta-synthase deficiency.
Topics: Adolescent; Adult; Aged; Amination; Betaine; Child; Child, Preschool; Cystathionine beta-Synthase; Female; Homocysteine; Homocystinuria; Humans; Infant; Lipotropic Agents; Male; Methionine; Middle Aged; Transaminases | 2000 |
Elevated homocysteine levels in patients with Raynaud's syndrome.
Topics: Cystatin C; Cystatins; False Negative Reactions; Fasting; Glomerular Filtration Rate; Homocysteine; Homocystinuria; Humans; Methionine; Raynaud Disease; Scleroderma, Systemic | 2000 |
Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis.
Topics: Betaine; Child, Preschool; Diagnosis, Differential; Fatal Outcome; Fibroblasts; Folic Acid; Hematinics; Homocysteine; Homocystinuria; Homozygote; Humans; Infant; Intellectual Disability; Lipotropic Agents; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Treatment Outcome | 2000 |
Homocysteine levels during fasting and after methionine loading in adolescents with diabetic retinopathy and nephropathy.
Topics: Adolescent; Adult; Age of Onset; Albuminuria; Child; Cholesterol, LDL; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Fasting; Female; Homocysteine; Humans; Lipoprotein(a); Male; Methionine; Regression Analysis; Statistics, Nonparametric | 2000 |
The (non-)sense of the methionine loading test for detecting hyperhomocysteinaemia.
Topics: Cardiovascular Diseases; Fasting; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine | 2000 |
Moderately low vitamin B12 does not compromise transmethylation in adults on a free diet: implications for assessment of vitamin B12 status.
Topics: Analysis of Variance; Creatine; Dietary Proteins; Homocysteine; Humans; Methionine; Methylation; Reference Values; Statistics as Topic; Vitamin B 12 | 2000 |
[Homocysteine and its metabolites in chronic renal insufficiency and the effect of a vitamin replacement].
Topics: Adult; Aged; Arteriosclerosis; Cysteine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Pyridoxine; Renal Dialysis; Severity of Illness Index; Vitamin B 12; Vitamin B Complex | 2000 |
Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Division; DNA Mutational Analysis; DNA, Complementary; Gene Deletion; Gene Expression; Homocysteine; Humans; Methionine; Phenotype; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tumor Cells, Cultured | 2000 |
Homocysteine levels in vegetarians versus omnivores.
Topics: Adult; Aged; Diet; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Slovakia; Surveys and Questionnaires; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Defining the steps of the folate one-carbon shuffle and homocysteine metabolism.
Topics: Folic Acid; Glycine; Homocysteine; Humans; Methionine; Methylation; Serine | 2000 |
Primed, constant infusion with [2H3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism.
Topics: Adult; Amino Acids; Cytosol; Folic Acid; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Male; Methionine; Methylation; Mitochondria; Nutritional Status; Pilot Projects; Serine | 2000 |
Excess dietary methionine markedly increases the vitamin B-6 requirement of young chicks.
Topics: Animals; Cardiovascular Diseases; Chickens; Dietary Proteins; Growth; Homocysteine; Methionine; Models, Animal; Nutritional Requirements; Pyridoxine; Soybean Proteins; Weight Gain | 2000 |
Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.
Topics: Administration, Oral; Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Diseases; Cystine; Diet; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Male; Methionine; Rats; Rats, Sprague-Dawley; Tunica Intima; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Influence of 699C-->T and 1080C-->T polymorphisms of the cystathionine beta-synthase gene on plasma homocysteine levels.
Topics: Adult; Aged; Aged, 80 and over; Coronary Disease; Cystathionine beta-Synthase; Fasting; Female; Genotype; Homocysteine; Humans; Male; Methionine; Middle Aged; Point Mutation; Polymorphism, Genetic | 2000 |
Targeted disruption of the methionine synthase gene in mice.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Base Sequence; Cardiovascular Diseases; DNA Primers; Embryonic and Fetal Development; Female; Folic Acid; Gene Targeting; Heterozygote; Homocysteine; Homozygote; Humans; Methionine; Mice; Mice, Knockout; Neural Tube Defects; Pregnancy; Risk Factors; Vitamin B 12 Deficiency | 2001 |
Is there a role of cyclosporine A on total homocysteine export from human renal proximal tubular epithelial cells?
Topics: Biological Transport, Active; Cells, Cultured; Cyclosporine; Epithelial Cells; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Kidney Transplantation; Kidney Tubules, Proximal; Methionine; Pyridoxine; Vitamin B 12 | 2001 |
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans.
Topics: Acute Disease; Adult; Arginine; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroglycerin; Vasodilation; Vasodilator Agents | 2001 |
Clinical relevance of the methionine loading test for assessment of hyperhomocysteinaemia.
Topics: Cardiovascular Diseases; Fasting; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine; Risk Factors | 2000 |
Effects of methionine loading on plasma and erythrocyte sulphur amino acids and sulph-hydryls before and after co-factor supplementation in haemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Sulfur; Case-Control Studies; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxine; Renal Dialysis; Sulfhydryl Compounds | 2001 |
Homocysteine and human reproduction.
Topics: Culture Techniques; Female; Folic Acid; History, 17th Century; History, 20th Century; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Reproduction | 2000 |
Traditional and alternative nutrition--levels of homocysteine and lipid parameters in adults.
Topics: Adult; Aged; Arteriosclerosis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dairy Products; Diet, Vegetarian; Eggs; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Methionine; Middle Aged; Nutritional Physiological Phenomena; Reference Values; Risk Factors; Vitamin B 12 | 2000 |
Occurrence of transsulfuration in synthesis of L-homocysteine in an extremely thermophilic bacterium, Thermus thermophilus HB8.
Topics: Culture Media; Cystathionine; Cystathionine gamma-Lyase; Cysteine; Cysteine Synthase; Gene Expression Regulation, Bacterial; Homocysteine; Lyases; Methionine; S-Adenosylmethionine; Sulfur; Temperature; Thermus thermophilus | 2001 |
Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia.
Topics: Birth Weight; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Primers; Electrophoresis, Polyacrylamide Gel; Female; Folic Acid; Genotype; Gestational Age; HELLP Syndrome; Homocysteine; Humans; Infant, Newborn; Linear Models; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Pre-Eclampsia; Pregnancy; Radioimmunoassay; Regression Analysis; Vitamin B 12 | 2001 |
Short-term variability in the measurement of plasma homocysteine, fasting and post-methionine loading.
Topics: Adult; Aged; Confidence Intervals; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Models, Statistical; Reference Values; Reproducibility of Results; Time Factors | 2001 |
How methionyl-tRNA synthetase creates its amino acid recognition pocket upon L-methionine binding.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Binding, Competitive; Crystallization; Crystallography, X-Ray; Escherichia coli; Homocysteine; Hydrogen Bonding; Methionine; Methionine-tRNA Ligase; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity; Water | 2001 |
C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Coronary Disease; Fasting; Female; Fluorometry; Genotype; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prevalence; Venous Thrombosis | 2001 |
Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study.
Topics: Adult; Cardiovascular Diseases; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Risk Factors | 2001 |
Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro.
Topics: Adult; Analysis of Variance; Cells, Cultured; Cytochalasin B; Dose-Response Relationship, Drug; Homocysteine; Humans; Lymphocytes; Male; Methionine; Micronucleus Tests; Models, Chemical; Mutagens; Necrosis; Time Factors | 2001 |
Folate, homocysteine and methionine loading in patients on carbamazepine.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged | 2001 |
Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype.
Topics: Adolescent; Adult; Aged; Cystathionine; Cystathionine beta-Synthase; DNA; Female; Genotype; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Middle Aged; Mutation; Phenotype; Reference Values | 2001 |
Simultaneous determination of total plasma glutathione, homocysteine, cysteinylglycine, and methionine by high-performance liquid chromatography with electrochemical detection.
Topics: Aging; Calibration; Chromatography, High Pressure Liquid; Diabetes Mellitus; Dipeptides; Female; Glutathione; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Quality Control; Reference Values; Risk Factors; Sensitivity and Specificity | 2001 |
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
Topics: Adenosine; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cystathionine beta-Synthase; Cysteine; DNA Methylation; Down Syndrome; Glutathione; Homocysteine; Humans; Leucovorin; Lymphocytes; Methionine; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Superoxide Dismutase; Thymidine; Vitamin B 12 | 2001 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
Normal human lymphocytes exhibit a wide range of methionine-dependency which is related to altered cell division but not micronucleus frequency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Cell Count; Cell Cycle; Cell Division; Culture Media; Female; Homocysteine; Humans; Lymphocytes; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Micronuclei, Chromosome-Defective; Micronucleus Tests; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors | 2001 |
Cystatin C is an independent predictor of fasting and post-methionine load total homocysteine concentrations among stable renal transplant recipients.
Topics: Adult; Aged; Biomarkers; Cystatin C; Cystatins; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male; Methionine; Middle Aged; Regression Analysis | 2001 |
Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Cardiovascular Diseases; Dopa Decarboxylase; Down-Regulation; Drug Interactions; Enzyme Inhibitors; Female; Homocysteine; Humans; Levodopa; Male; Methionine; Middle Aged; Parkinson Disease; S-Adenosylmethionine; Up-Regulation | 2001 |
The role of cysteine and homocysteine in venous and arterial thrombotic disease.
Topics: Adult; Aged; Aged, 80 and over; Arteries; Cysteine; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Myocardial Infarction; Reference Values; Thrombosis; Venous Thrombosis | 2001 |
Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions.
Topics: Acylation; Amino Acid Sequence; Binding Sites; Coenzyme A; Cysteine; Cytoplasm; Genes, Fungal; Genetic Complementation Test; Homocysteine; Kinetics; Methionine; Methionine-tRNA Ligase; Mitochondria; Molecular Sequence Data; Mutation; Protein Transport; RNA, Transfer, Met; Saccharomyces cerevisiae; Sequence Alignment; Structure-Activity Relationship; Zinc; Zinc Fingers | 2001 |
Mild hyperhomocysteinemia: vitamin supplementation or not?
Topics: Adult; Case-Control Studies; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Mutation; Polymorphism, Genetic; Vascular Diseases; Vitamins | 2001 |
Basal and post-methionine serum homocysteine and lipoprotein abnormalities in patients with chronic liver disease.
Topics: Aged; Apolipoproteins B; Case-Control Studies; Cholesterol; Chronic Disease; Coronary Disease; Female; Homocysteine; Humans; Lipoprotein(a); Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Liver Cirrhosis, Biliary; Liver Diseases; Methionine; Middle Aged; Risk Factors; Triglycerides | 2001 |
Simultaneous determination of methionine and total homocysteine in human plasma by gas chromatography-mass spectrometry.
Topics: Adult; Calibration; Female; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Methionine; Middle Aged; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Simultaneous analysis of homocysteine and methionine in plasma.
Topics: Cation Exchange Resins; Chromatography, Ion Exchange; Homocysteine; Humans; Methionine; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Hydrocephalus internus in two patients with 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Cerebral Ventricles; Demyelinating Diseases; Female; Homocysteine; Humans; Hydrocephalus; Hyperhomocysteinemia; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases | 2000 |
[Effect of vitamin B6, B12 and folic acid levels on basal blood homocysteine values and after methionine load].
Topics: Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Vitamin B 12; Vitamin B 6 | 2001 |
Biosynthesis of methionine from homocysteine, cystathionine and homoserine plus cysteine by mixed rumen microorganisms in vitro.
Topics: Amino Acids; Aminobutyrates; Anaerobiosis; Animals; Bacteria; Culture Media; Cystathionine; Cysteine; Eukaryota; Goats; Homocysteine; Homoserine; Methionine; Rumen; Temperature | 2001 |
Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice.
Topics: Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Collagen; Coronary Artery Disease; Dietary Supplements; Female; Homocysteine; Hyperhomocysteinemia; Lipids; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Thrombosis | 2001 |
Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver.
Topics: Allosteric Regulation; Animals; Biological Transport; Cystathionine beta-Synthase; Glucagon; Homocysteine; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley; Sulfur | 2001 |
Methylation is involved in the Ustilago maydis mating response.
Topics: Cyclic AMP; Ethionine; Homocysteine; Methionine; Methylation; Methyltransferases; Mutation; Pheromones; Plants; Reproduction; S-Adenosylmethionine; Signal Transduction; Ustilago | 2001 |
Determinants of homocysteine during weight reduction in obese children and adolescents.
Topics: Adolescent; Age Factors; Body Composition; Body Mass Index; C-Peptide; Child; Folic Acid; Homocysteine; Humans; Methionine; Obesity; Regression Analysis; Time Factors; Weight Loss | 2001 |
Total plasma homocysteine and related amino acids in end-stage renal disease (ESRD) patients measured by gas chromatography-mass spectrometry--comparison with the Abbott IMx homocysteine assay and the HPLC method.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Amino Acids; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Models, Chemical; Reference Values; Sex Factors | 2001 |
Does a single vitamin B-supplementation induce functional vitamin B-deficiency?
Topics: Adult; Cystathionine; Cysteine; Dietary Supplements; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Methionine; Methylmalonic Acid; Middle Aged; Models, Biological; Pilot Projects; Time Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2001 |
Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenine Nucleotides; Amidinotransferases; Animals; Creatine; Diet; Glycine; Hepatocytes; Homocysteine; Kidney; Liver; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Muscle, Skeletal; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley | 2001 |
CblC/D defect combined with haemodynamically highly relevant VSD.
Topics: Female; Folic Acid; Heart Septal Defects, Ventricular; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Infant, Newborn; Lactic Acid; Metabolism, Inborn Errors; Methionine; Methylmalonic Acid | 2001 |
Homocysteine-induced decrease in endothelin-1 production is initiated at the extracellular level and involves oxidative products.
Topics: Antioxidants; Cell Line; Endothelin-1; Endothelium; Extracellular Space; Homocysteine; Humans; Hydrogen Peroxide; Intracellular Fluid; Methionine; Oxidants; Oxidation-Reduction; Reactive Oxygen Species | 2001 |
Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Catalase; Cell Division; DNA Fragmentation; DNA, Neoplasm; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Homocysteine; Humans; Hydrogen Peroxide; Malondialdehyde; Methionine; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Transcription Factors; Tumor Cells, Cultured | 2001 |
Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis.
Topics: Adolescent; Adult; Aged; Child; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Risk Factors; Venous Thrombosis; Vitamin B 12; Vitamin B 6 | 2001 |
Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis.
Topics: Arteriosclerosis; Cells, Cultured; Female; Fibrosis; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Liver Cirrhosis; Male; Methionine; Middle Aged; Models, Chemical; Muscle, Smooth, Vascular; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2001 |
Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Arteriosclerosis; Cattle; Cell Line; Culture Techniques; Endothelium, Vascular; Homocysteine; Hydrolases; Hyperhomocysteinemia; Kinetics; Methionine; Nitric Oxide; Nitric Oxide Synthase; Recombinant Fusion Proteins; Signal Transduction | 2001 |
Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects.
Topics: Aged; Aged, 80 and over; Aging; Dementia; Diabetes Complications; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Kinetics; Linear Models; Male; Methionine; Nutrition Disorders; Odds Ratio; Renal Insufficiency; Vascular Diseases | 2001 |
Hyperhomocysteinaemia and folate deficiency in human immunodeficiency virus-infected children.
Topics: Adolescent; Anti-HIV Agents; Child; Child, Preschool; Female; Folic Acid Deficiency; HIV Infections; HIV-1; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Male; Methionine; Statistics as Topic; Vitamin B 12 | 2001 |
Hyperhomocysteinemia in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Topics: Adult; Age Distribution; Biopsy; Case-Control Studies; Cerebral Arterial Diseases; Dementia, Multi-Infarct; Dementia, Vascular; DNA Mutational Analysis; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenotype; Risk Factors; Sex Distribution | 2001 |
Metabolism of amino acids in cats with severe cobalamin deficiency.
Topics: Amino Acids; Animals; Cat Diseases; Cats; Cystathionine; Cysteine; Female; Gastrointestinal Diseases; Homocysteine; Immunoassay; Male; Methionine; Methylmalonic Acid; Statistics, Nonparametric; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Plasma folate but not vitamin B(12) or homocysteine concentrations are reduced after short-term vitamin B(6) supplementation.
Topics: Adult; Area Under Curve; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Pyridoxal Phosphate; Pyridoxine; Vitamin B 12; Vitamin B 6 | 2001 |
Diet-induced mild hyperhomocysteinemia and increased salt intake diminish vascular endothelial function in a synergistic manner.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Pressure; Carotid Artery, Common; Drug Synergism; Endothelium, Vascular; Folic Acid; Heart Rate; Homocysteine; Hyperhomocysteinemia; Japan; Kidney; Lipid Peroxidation; Lipids; Male; Methionine; Natriuresis; Nitrites; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sodium Chloride, Dietary | 2002 |
Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; False Negative Reactions; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Male; Methionine; Middle Aged; Photochemistry; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Thrombophilia; Thrombosis | 2002 |
Physiologic mechanisms to maintain methionine status during protein malnutrition.
Topics: Adaptation, Physiological; Amino Acids, Essential; Dietary Proteins; Homeostasis; Homocysteine; Humans; Methionine; Nutrition Disorders | 2002 |
Methionine synthase activity and sulphur amino acid levels in the rat liver tumour cells HTC and Phi-1.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosine Triphosphate; Amino Acids, Sulfur; Animals; Cell Division; Culture Media; Cysteine; Glutathione; Hepatocytes; Homocysteine; Methionine; Rats; Taurine; Tumor Cells, Cultured | 2002 |
Effects of hormone replacement therapy and methylenetetrahydrofolate reductase polymorphism on plasma folate and homocysteine levels in postmenopausal Japanese women.
Topics: Adult; Aged; Aged, 80 and over; Apolipoproteins; DNA; Estrogens; Female; Folic Acid; Homocysteine; Hormone Replacement Therapy; Humans; Japan; Lipids; Medroxyprogesterone Acetate; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Polymorphism, Genetic; Progesterone Congeners; Regression Analysis | 2002 |
Inhibition of rat brain Na+, K+-ATPase activity induced by homocysteine is probably mediated by oxidative stress.
Topics: Animals; Brain; Chromans; Hippocampus; Homocysteine; Kinetics; Methionine; Oxidative Stress; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase | 2001 |
Implications of hyperhomocysteinemia in glomerular sclerosis in hypertension.
Topics: Animals; Chromatography, High Pressure Liquid; Diet; Disease Models, Animal; Glomerular Mesangium; Homocysteine; Hyperhomocysteinemia; Hypertension; Methionine; Rats; Rats, Sprague-Dawley; Salts; Sclerosis | 2002 |
Abnormal cobalamin-dependent transmethylation in AIDS-associated myelopathy.
Topics: Adult; Female; Glutathione; HIV Infections; Homocysteine; Humans; Male; Methionine; Methylation; Middle Aged; S-Adenosylmethionine; Spinal Cord Diseases; Vitamin B 12 | 2002 |
Evidence for the involvement of tetrahydrofolate in the demethylation of nicotine by Nicotiana plumbaginifolia cell-suspension cultures.
Topics: Carbon Radioisotopes; Cells, Cultured; Cysteine; Homocysteine; Magnetic Resonance Spectroscopy; Methionine; Methylation; Models, Chemical; Nicotiana; Nicotine; Plant Extracts; Serine; Tetrahydrofolates | 2002 |
Electrochemical and spectral studies of the reactions of aquocobalamin with nitric oxide and nitrite ion.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anions; Catalysis; Electrochemistry; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Homocysteine; Hydroxocobalamin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methionine; Molecular Structure; Nitric Oxide; Nitrites; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Vitamin B 12 | 2002 |
Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cysteine; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Homocysteine; Kidney; Liver; Male; Methionine; Methyltransferases; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred F344; Selenium | 2002 |
Methionine-loading test: evaluation of adverse effects and safety in an epidemiological study.
Topics: Arteriosclerosis; Blood Pressure; Cohort Studies; Dizziness; Epidemiologic Studies; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Nausea; Polymers; Safety | 2002 |
Inhibition of Na+, K+-ATPase activity by the metabolites accumulating in homocystinuria.
Topics: Animals; Enzyme Inhibitors; Hippocampus; Homocysteine; Homocystinuria; Methionine; Neurons; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Subcellular Fractions; Synaptic Membranes | 2002 |
Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity.
Topics: Acetic Acid; Culture Media; Escherichia coli; Food Preservation; Homocysteine; Hydrogen-Ion Concentration; Methionine | 2002 |
Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line; Colonic Neoplasms; Enzyme Inhibitors; Exons; Female; Fibroblasts; Genetic Therapy; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasm Proteins; Neuroblastoma; Oligodeoxyribonucleotides, Antisense; Oxidoreductases Acting on CH-NH Group Donors; RNA, Messenger; RNA, Neoplasm; Thionucleotides; Tumor Cells, Cultured; Vitamin B 12 | 2002 |
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.
Topics: Animals; DNA; DNA Methylation; Ethanol; Folic Acid; Folic Acid Deficiency; Homocysteine; Lipid Peroxidation; Liver; Male; Methionine; Oxidation-Reduction; Swine; Swine, Miniature | 2002 |
[The abnormal reaction to post methionine loading test in type diabetes with or without retinopathy].
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Nitrates; Oxidoreductases Acting on CH-NH Group Donors; Time Factors | 2002 |
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
Topics: Adolescent; Child; Child, Preschool; Cystathionine; Cystathionine beta-Synthase; Female; Homocysteine; Humans; Infant; Isoenzymes; Lyases; Male; Methionine; Methionine Adenosyltransferase | 2002 |
Synthesis of optically active homocysteine from methionine and its use in preparing four stereoisomers of cystathionine.
Topics: Cystathionine; Homocysteine; Methionine; Optical Rotation; Stereoisomerism | 2002 |
Plasma sulfur amino acids in relation to cardiovascular disease, nutritional status, and diabetes mellitus in patients with chronic renal failure at start of dialysis therapy.
Topics: Adult; Amino Acids, Sulfur; Cardiovascular Diseases; Cross-Sectional Studies; Cysteine; Deficiency Diseases; Diabetic Nephropathies; Female; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Nutrition Assessment; Nutrition Disorders; Nutritional Status; Prevalence; Protein-Energy Malnutrition; Renal Dialysis; Serum Albumin | 2002 |
Vascular responses in male and female hypertensive rats with hyperhomocysteinemia.
Topics: Animals; Blood Pressure; Culture Techniques; Endothelium, Vascular; Estradiol; Female; Homocysteine; Hyperhomocysteinemia; Hypertension; Male; Methionine; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Sex Factors; Vasoconstriction; Vasodilation | 2002 |
Influence of age, sex and vitamin status on fasting and post-methionine load plasma homocysteine levels.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Fasting; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Sex Characteristics; Time Factors; Vitamins | 2002 |
Acute valproate administration impairs methionine metabolism in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Anticonvulsants; Betaine-Homocysteine S-Methyltransferase; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methyltransferases; Models, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Teratogens; Valproic Acid; Vitamin B 6 | 2002 |
L-cysteine prevents oxidation-induced block of the cardiac Na+ channel via interaction with heart-specific cysteinyl residues in the P-loop region.
Topics: Cysteine; Dose-Response Relationship, Drug; Homocysteine; Humans; Mercury; Methionine; Myocardium; Oxidation-Reduction; Patch-Clamp Techniques; Sodium Channels | 2002 |
Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia.
Topics: Age Factors; Animal Feed; Animals; Choline; Folic Acid; Homocysteine; Hyperhomocysteinemia; Methionine; Nephritis, Interstitial; Rats; Rats, Inbred F344; Weaning | 2002 |
Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli.
Topics: Escherichia coli; Homocysteine; Homoserine; Kinetics; Methionine; Neurospora crassa | 1967 |
Remethylation and transsulfuration of methionine in cirrhosis: studies with L-[H3-methyl-1-C]methionine.
Topics: Adult; Carbon Isotopes; Homocysteine; Humans; Kinetics; Liver Cirrhosis, Alcoholic; Male; Methionine; Methylation; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tritium | 2002 |
Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming.
Topics: Abortion, Spontaneous; Amino Acids; Animals; Blastocyst; Diet, Protein-Restricted; Disease Susceptibility; Embryonic and Fetal Development; Female; Gestational Age; Homocysteine; Methionine; Mice; Mice, Inbred Strains; Models, Animal; Pre-Eclampsia; Pregnancy; Prenatal Nutritional Physiological Phenomena; Rats; Rats, Inbred Strains | 2002 |
Homocysteine promotes the LDL oxidase activity of ceruloplasmin.
Topics: Ceruloplasmin; Copper; Cysteine; Homocysteine; Humans; Indicators and Reagents; Lipoproteins, HDL; Lipoproteins, LDL; Methionine; Oxidation-Reduction; Phenanthrolines | 2002 |
Metabolic response of normal and malignant tissue to acute and chronic methionine stress in athymic mice bearing human glial tumor xenografts.
Topics: Animals; Brain Neoplasms; Carbon-Sulfur Lyases; Choline; Choline Deficiency; Glioma; Homocysteine; Humans; Liver; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2002 |
Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction.
Topics: Animals; Aorta, Thoracic; Carotid Arteries; Catalase; Diet; Endothelium, Vascular; Ethidium; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Superoxide Dismutase; Superoxides; Vasomotor System | 2002 |
The effect of folic acid, vitamin B6 and vitamin B12 on the homocysteine levels in rabbits fed by methionine-enriched diets.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Drug Combinations; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rabbits; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2002 |
Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
Topics: Anemia; Anemia, Pernicious; Cysteine; Dipeptides; Folic Acid; Glutathione; Homocysteine; Humans; Memory Disorders; Methionine; Movement Disorders; Nervous System Diseases; Retrospective Studies; S-Adenosylmethionine; Sensation Disorders; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Induction of caspase-dependent and -independent apoptosis in response to methionine restriction.
Topics: Adenocarcinoma; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cysteine Endopeptidases; Cytochrome c Group; DNA Fragmentation; Enzyme Induction; Enzyme Precursors; Female; HeLa Cells; Homocysteine; Humans; Male; Methionine; Mitochondria; Neoplasm Proteins; Prostatic Neoplasms; Stress, Physiological; Tumor Cells, Cultured | 2003 |
CblE type of homocystinuria due to methionine synthase reductase deficiency: clinical and molecular studies and prenatal diagnosis in two families.
Topics: Adult; Anemia, Megaloblastic; Base Sequence; Cells, Cultured; Child; Chromatography, Ion Exchange; DNA; Female; Ferredoxin-NADP Reductase; Fibroblasts; Folic Acid; Homocysteine; Homocystinuria; Humans; Methionine; Molecular Sequence Data; Mutation; Prenatal Diagnosis; Reverse Transcriptase Polymerase Chain Reaction; Serine; Vitamin B 12 | 2002 |
Hyperhomocysteinemia: could the post-methionine oral loading test sometimes be avoided?
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Sensitivity and Specificity; Thrombosis | 2003 |
Urinary sulfur excretion and the nitrogen/sulfur balance ratio reveal nonprotein sulfur amino acid retention in piglets.
Topics: Amino Acids, Sulfur; Animals; Animals, Newborn; Diet, Protein-Restricted; Dietary Proteins; Energy Intake; Glutathione; Homocysteine; Magnesium Sulfate; Male; Methionine; Nitrogen; Sulfur; Swine; Taurine; Weight Gain | 2003 |
Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women.
Topics: Adult; Diet; Female; Folic Acid; Glycine max; Homocysteine; Humans; Isoflavones; Methionine; Middle Aged; Nutritional Status; Premenopause; Soybean Proteins; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6 | 2003 |
Variability of post-methionine load plasma homocysteine assays.
Topics: Adult; Clinical Laboratory Techniques; Fasting; Homocysteine; Humans; Laboratories; Male; Methionine; Reference Values; Statistics as Topic; Time Factors | 2003 |
Effect of a methionine-supplemented diet on the blood pressure of Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta; Bradykinin; Cysteine; Dietary Supplements; Endothelium, Vascular; Glutathione; Homocysteine; Hyperhomocysteinemia; Hypertension; Male; Methionine; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium; Systole; Vasodilator Agents | 2003 |
Homocysteine and methionine transamination.
Topics: Artifacts; Aspartate Aminotransferases; Homocysteine; Humans; Indicators and Reagents; Methionine; Renal Dialysis; Uremia; Vitamin B 6; Vitamin B 6 Deficiency | 2003 |
Low diagnostic value of fasting and post-methionine load homocysteine tests. A study in Dutch subjects with homocysteine test indications.
Topics: Adult; Cardiovascular Diseases; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Netherlands; Prevalence; Reference Values; Retrospective Studies; Risk Factors; Sensitivity and Specificity | 2003 |
Changes in markers of vascular injury in response to transient hyperhomocysteinemia.
Topics: Adult; Animals; Biomarkers; Blood Vessels; Enzyme-Linked Immunosorbent Assay; Female; Fibronectins; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Transgenic; Vascular Cell Adhesion Molecule-1 | 2003 |
Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation.
Topics: Adult; Area Under Curve; Case-Control Studies; Chronic Disease; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases; Liver Transplantation; Male; Metabolic Clearance Rate; Methionine; Middle Aged; Vitamin B 12; Vitamin B 6 | 2003 |
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice.
Topics: Animals; Betaine; Central Nervous System Depressants; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Fatty Liver, Alcoholic; Gastrointestinal Agents; Gene Expression; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis | 2003 |
Effects of long-term administration of methionine on vascular endothelium in rabbits.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cysteine; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Isometric Contraction; Lipids; Male; Methionine; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; Rabbits; Superoxide Dismutase; Thromboplastin; Time Factors; Triglycerides | 2003 |
High methionine and cholesterol diet abolishes endothelial relaxation.
Topics: Animals; Aorta, Abdominal; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Endothelium, Vascular; Homocysteine; Isometric Contraction; Male; Methionine; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Phenylephrine; Rabbits; Triglycerides | 2003 |
Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Brachiocephalic Trunk; Diet; Dietary Supplements; Female; Homocysteine; Hyperhomocysteinemia; Lipids; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Vitamins | 2003 |
Molecular aspects of methionine biosynthesis.
Topics: Gene Expression Regulation, Plant; Homocysteine; Methionine; Plants; Plants, Genetically Modified; Sulfur | 2003 |
Brain energy metabolism is compromised by the metabolites accumulating in homocystinuria.
Topics: Animals; Brain; Carbon Dioxide; Disease Models, Animal; Electron Transport Complex IV; Energy Metabolism; Glucose; Hippocampus; Homocysteine; Homocystinuria; Methionine; Rats; Rats, Wistar | 2003 |
Limited effectiveness of betaine therapy for cystathionine beta synthase deficiency.
Topics: Betaine; Child, Preschool; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Male; Methionine; Treatment Outcome | 2003 |
Use of disposable gold working electrodes for cation chromatography-integrated pulsed amperometric detection of sulfur-containing amino acids.
Topics: Calibration; Cations; Chromatography, Ion Exchange; Cysteine; Disposable Equipment; Gold; Homocysteine; Ion-Selective Electrodes; Methionine; Quality Control; Reproducibility of Results; Time Factors | 2003 |
Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Substitution; Catalysis; Escherichia coli; Escherichia coli Proteins; Homocysteine; Methionine; Methylation; Mutation, Missense; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Temperature; Tetrahydrofolates; Vitamin B 12 | 2003 |
Severe methylenetetrahydrofolate reductase deficiency, methionine synthase, and nitrous oxide--a cautionary tale.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Anesthetics, Inhalation; Folic Acid; Homocysteine; Humans; Male; Metabolism, Inborn Errors; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Nitrous Oxide; Oxidoreductases; Point Mutation | 2003 |
Adverse effect of nitrous oxide in a child with 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Anesthetics, Inhalation; Cells, Cultured; DNA Mutational Analysis; Fatal Outcome; Fibroblasts; Folic Acid; Genes, Recessive; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Infant; Male; Metabolism, Inborn Errors; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Nitrous Oxide; Oxidoreductases; Point Mutation; Polymorphism, Genetic; RNA | 2003 |
Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease.
Topics: Analysis of Variance; Coronary Artery Disease; Cystathionine beta-Synthase; Gene Frequency; Genetic Variation; Genotype; Heterozygote; Homocysteine; Humans; Logistic Models; Methionine; Mutation; Polymorphism, Genetic; Risk Factors | 2003 |
Plasma thiols and their determinants in phenylketonuria.
Topics: Adolescent; Cross-Sectional Studies; Cysteine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Male; Methionine; Phenylalanine; Phenylketonurias; Sulfhydryl Compounds; Vitamin B 12 | 2003 |
Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation.
Topics: Cell Transformation, Viral; Cells, Cultured; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Lymphocytes; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Riboflavin; Tetrahydrofolates | 2003 |
Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aspergillus nidulans; Base Sequence; Betaine; Choline; Cloning, Molecular; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Homocysteine; Methionine; Models, Biological; Molecular Sequence Data; RNA, Messenger; Transcription, Genetic | 2003 |
Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cells.
Topics: Cells, Cultured; Concanavalin A; Folic Acid; Homocysteine; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Methionine; Phytohemagglutinins; Pokeweed Mitogens; Statistics, Nonparametric | 2003 |
The biosynthesis of methionine from homocysteine and methylmethionine sulfonium salt.
Topics: Butyrates; Enterobacter aerogenes; Homocysteine; Lipid Metabolism; Methionine; Sodium Chloride; Vitamin U | 1955 |
Biosynthesis of methionine from homocysteine and s-methylmethionine in bacteria.
Topics: Bacteria; Cysteine; Homocysteine; Methionine; Vitamin U | 1956 |
The synthesis of methionine by enzymic transmethylation. I. Purification and properties of thetin homocysteine methylpherase.
Topics: Biochemical Phenomena; Homocysteine; Liver; Methionine; Transferases | 1957 |
The synthesis of methionine by enzymic transmethylation. VI. Studies of the homogeneity, shape properties and monomer functionality of thetin-homocysteine methylpherase.
Topics: Homocysteine; Macromolecular Substances; Methionine; Transferases | 1960 |
The synthesis of methionine by enzymic transmethylation. III. Mechanism of the reversible polymerization of thetin-homocysteine methylpherase and its relation to the mechanism of methionine synthesis.
Topics: Biochemical Phenomena; Homocysteine; Methionine; Polymerization; Transferases | 1959 |
The synthesis of methionine by enzymic transmethylation. IV. Light scattering studies of the depolymerization of thetin-homocysteine methylpherase.
Topics: Homocysteine; Methionine; Polymerization; Transferases | 1960 |
[Ethionine pancreatitis in the rat. II. Attempts to prevent ethionine injury by methionine, cysteine-homocysteine, choline and betaine].
Topics: Animals; Betaine; Choline; Cysteine; Ethionine; Homocysteine; Methionine; Pancreatitis; Rats | 1960 |
The synthesis of methionine from homocysteine by enzymic extracts of Escherichia coli.
Topics: Cysteine; Escherichia coli; Homocysteine; Methionine | 1960 |
[Synthesis of natural sulfurated amino acids].
Topics: Amino Acids; Cysteine; Cystine; Homocysteine; Methionine; Serine | 1962 |
The identification of homocystine in the urine.
Topics: Body Fluids; Homocysteine; Homocystine; Humans; Methionine | 1962 |
A study of the action of methionine homologues at cellular level and in the systems of organized growth.
Topics: Embryo, Mammalian; Embryo, Nonmammalian; Ethionine; Homocysteine; Methionine; Tetrahymena | 1962 |
ACTION OF FORMALDEHYDE ON MICROORGANISMS. II. FORMATION OF 1,3-THIAZANE-4-CARBOXYLIC ACID IN AEROBACTER AEROGENES TREATED WITH FORMALDEHYDE.
Topics: Carboxylic Acids; Chromatography; Enterobacter aerogenes; Formaldehyde; Homocysteine; Manometry; Metabolism; Methionine; Research; Sulfhydryl Compounds; Thiazines; Valine | 1963 |
CYSTINURIA: METABOLISM OF THE DISULFIDE OF CYSTEINE AND HOMOCYSTEINE.
Topics: Amino Acids; Chromatography; Cysteine; Cystinuria; Disulfides; Dogs; Hepatolenticular Degeneration; Homocysteine; Ion Exchange Resins; Kidney Diseases; Metabolic Diseases; Methionine; Proteins; Rats; Sulfonic Acids; Sulfur Isotopes | 1963 |
EFFECT OF VITAMIN B12 ANALOGUES ON METHIONINE FORMATION FROM N5-METHYLTETRAHYDROFOLIC ACID.
Topics: Carbon Isotopes; Corrinoids; Escherichia coli; Folic Acid; Homocysteine; Methionine; Pharmacology; Proteins; Research; Sulfhydryl Compounds; Vitamin B 12 | 1964 |
STUDIES OF SULFATE UTILIZATION BY ALGAE. 3. PRODUCTS FORMED FROM SULFATE BY EUGLENA.
Topics: Amides; Chromatography; Cysteine; Euglena; Glutathione; Homocysteine; Infrared Rays; Iodoacetates; Metabolism; Methionine; Pharmacology; Research; Sulfates; Sulfur Isotopes; Sulfur Oxides | 1964 |
STUDIES ON THE MECHANISM OF ESCHERICHIA COLI RESISTANCE TO ETHIONINE.
Topics: Amino Acids; Biochemical Phenomena; Carbon Isotopes; Drug Resistance; Drug Resistance, Microbial; Escherichia coli; Ethionine; Homocysteine; Methionine; Research | 1963 |
PROGRESS REPORT: BIOSYNTHESIS OF METHIONINE FROM HOMOCYSTEINE AND SULFONIUM DERIVATIVES IN ESCHERICHIA COLI. ANL-6723.
Topics: Escherichia coli; Homocysteine; Metabolism; Methionine; Nucleosides; Research; Research Report; Transferases | 1963 |
METHIONINE AND HOMOCYSTEINE AS PROTECTIVE AGENTS AGAINST IRRADIATION DAMAGE.
Topics: Blood Proteins; Body Weight; Brain; Choline; Homocysteine; Methionine; Neoplasms, Radiation-Induced; Neurochemistry; Nucleic Acids; Protective Agents; Proteins; Radiation Protection; Rats; Reproduction; Research | 1964 |
BIOSYNTHESIS OF METHIONINE IN SACCHAROMYCES CEREVISIAE; PARTIAL PURIFICATION AND PROPERTIES OF S-ADENOSYLMETHIONINE: HOMOCYSTEINE METHYLTRANSFERASE. ANL-6823.
Topics: Carbon Isotopes; Chromatography; Homocysteine; Homocysteine S-Methyltransferase; Metabolism; Methionine; Research; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Sulfur Isotopes; Toluene; Transferases | 1964 |
OROTIC ACID AND METABOLISM OF ONE CARBON UNIT: CONVERSION OF FOLIC ACID TO CITROVORUM FACTOR AND METHIONINE SYNTHESIS IN CHICK LIVER.
Topics: Animals; Carbon; Chickens; Folic Acid; Homocysteine; Leuconostoc; Leucovorin; Liver; Metabolism; Methionine; Orotic Acid; Poultry; Proteins; Research; Serine; Vitamin B 12; Vitamin B 12 Deficiency | 1963 |
ORGAN AND INTRACELLULAR LOCATION OF THE METHIONINE METHYL GROUP SYNTHESIZING SYSTEM OF THE RAT.
Topics: Adenosine Triphosphate; Brain; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Folic Acid; Glucose; Homocysteine; Kidney; Leuconostoc; Liver; Magnesium; Methionine; Muscles; NAD; Pectoralis Muscles; Proteins; Pyridoxal Phosphate; Rats; Research; Serine; Spectrophotometry | 1964 |
THE ROLE OF VITAMIN B12 IN METHYL TRANSFER TO HOMOCYSTEINE.
Topics: Chromatography; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Magnesium Sulfate; Mercaptoethanol; Methionine; Nucleosides; Pharmacology; Proteins; Research; Spectrophotometry; Sulfhydryl Compounds; Vitamin B 12 | 1964 |
METHYLCOBALAMIN AS A SOURCE OF THE METHYL GROUP OF METHIONINE.
Topics: Adenosine Triphosphate; Carbon Isotopes; Chromatography; Escherichia coli; Homocysteine; Methionine; Pharmacology; Proteins; Research; Vitamin B 12 | 1964 |
CONTROL MECHANISM IN THE RAT LIVER ENZYME SYSTEM CONVERTING L-METHIONINE TO L-CYSTINE. I. ENZYMATIC BASIS FOR THE METHIONINE-SPARING ACTION OF L-CYSTINE.
Topics: Cystine; Dietary Proteins; Homocysteine; Hydro-Lyases; Ligases; Liver; Manometry; Methionine; Proteins; Rats; Research | 1964 |
REPRESSION BY METHIONINE OF CYSTATHIONASE FORMATION IN ESCHERICHIA COLI.
Topics: Amino Acids; Chloramphenicol; Cystathionine gamma-Lyase; Cysteine; Enzymes; Escherichia coli; Homocysteine; Methionine; Proteins; Pyruvates; Research; Salmonella; Serine | 1964 |
SPECTROPHOTOMETRIC DETERMINATION OF DISULFIDES, SULFINIC ACIDS, THIO ETHERS, AND THIOLS WITH THE PALLADIUM (II) ION.
Topics: Benzoates; Cysteamine; Cysteine; Cystine; Disulfides; Ethers; Glutathione; Homocysteine; Lactones; Methionine; Palladium; Penicillamine; Phosphates; Research; Spectrophotometry; Sulfhydryl Compounds; Sulfides; Sulfinic Acids; Sulfites; Thiosulfates | 1964 |
SULPHUR NUTRITION OF TWO STRAINS OF THE YEAST, DEBARYOMYCES KLOECKERI, ISOLATED FROM SUBANTARCTIC SOIL.
Topics: Amino Acids; Cold Climate; Culture Media; Cysteine; Cystine; Ethionine; Glutathione; Homocysteine; Mercaptoethylamines; Metabolism; Methionine; Research; Saccharomyces; Saccharomyces cerevisiae; Soil; Soil Microbiology; Sulfates; Sulfides; Sulfites; Sulfonic Acids; Sulfur; Thiamine; Thiazoles; Thioctic Acid; Thioglycolates; Thiosulfates | 1964 |
BIOSYNTHESIS OF METHIONINE IN SACCHAROMYCES CEREVISIAE. PARTIAL PURIFICATION AND PROPERTIES OF S-ADENOSYLMETHIONINE: HOMOCYSTEINE METHYLTRANSFERASE.
Topics: Amino Acids; Chromatography; Homocysteine; Homocysteine S-Methyltransferase; Methionine; Nucleosides; Research; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Transferases | 1964 |
BIOSYNTHESIS OF MUSTARD OIL GLUCOSIDES. IV. THE ADMINISTRATION OF METHIONINE-C14 AND RELATED COMPOUNDS TO HORSERADISH.
Topics: Acetates; Amino Acids; Armoracia; Carbon Isotopes; Glucosides; Glycosides; Homocysteine; Metabolism; Methionine; Mustard Plant; Plant Oils; Plants; Research | 1964 |
STUDIES ON METHYL TRANSFER FROM 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE METHYL (METHYL-B12) TO HOMOCYSTEINE.
Topics: Carbon Isotopes; Chromatography; Corrinoids; Escherichia coli; Homocysteine; Methionine; Research; Spectrophotometry; Transferases; Vitamin B 12 | 1964 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. VII. ISOLATION OF A COBALAMIN-CONTAINING TRANSMETHYLASE (5-METHYLTETRAHYDRO-FOLATE-HOMOCYSTEINE) FROM MAMMALIAN LIVER.
Topics: Animals; Chromatography; Corrinoids; Flavin-Adenine Dinucleotide; Folic Acid; Glutamates; Homocysteine; Liver; Methionine; Methyltransferases; NAD; NADP; Protamines; Research; Swine; Transferases; Vitamin B 12 | 1964 |
O-SUCCINYLHOMOSERINE AS AN INTERMEDIATE IN THE SYNTHESIS OF CYSTATHIONINE BY ESCHERICHIA COLI.
Topics: Adenosine Triphosphate; Amino Acids; Chromatography; Coenzyme A; Cystathionine; Cysteine; Escherichia coli; Glucose; Homocysteine; Homoserine; Hot Temperature; Methionine; Research; Streptococcus; Succinates | 1964 |
PHOSPHATIDYLCHOLINE SYNTHESIS IN AGROBACTERIUM TUMEFACIENS. I. PURIFICATION AND PROPERTIES OF A PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE.
Topics: Agrobacterium; Agrobacterium tumefaciens; Autoradiography; Carbon Isotopes; Chromatography; Homocysteine; Lecithins; Lipid Metabolism; Methionine; Nucleosides; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Phospholipids; Research; Rhizobium; Transferases | 1964 |
HOMOCYSTINURIA. BIOCHEMICAL STUDIES OF TISSUES INCLUDING A COMPARISON WITH CYSTATHIONINURIA.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Brain; Brain Chemistry; Chemistry Techniques, Analytical; Cystathionine gamma-Lyase; Geriatrics; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Hyperhomocysteinemia; Methionine; Oxidoreductases; Transferases; Urine | 1965 |
THE REACTION OF INSULIN WITH N-ACETYL-DL-HOMOCYSTEINE THIOLACTONE: SOME CHEMICAL AND BIOLOGICAL PROPERTIES OF THE PRODUCTS.
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry; Chromatography; Homocysteine; Insulin; Iodoacetates; Lactones; Methionine; Pharmacology; Rabbits; Research; Sulfhydryl Compounds | 1964 |
THE INFLUENCE OF ETHIONINE, METHIONINE, CHOLINE, AND RELATED COMPOUNDS ON LIVER GLYCOGEN DEPOSITION IN ADRENALECTOMIZED RATS: RELATION TO THE MODE OF ACTION OF GLUCOCORTICOIDS.
Topics: Adrenalectomy; Choline; Cysteine; Ethionine; Glucocorticoids; Glucose; Homocysteine; Hydrocortisone; Liver; Liver Glycogen; Methionine; Pharmacology; Research; Serine; Tyrosine | 1964 |
STUDIES ON THE FORMATION OF BIOTIN FROM DESTHIOBIOTIN AND SULFATE IN SACCHAROMYCES CEREVISIAE. I. ON BIOTIN FORMATION FROM DESTHIOBIOTIN BY WASHED CELL SUSPENSION OF YEAST.
Topics: Biotin; Cysteine; Glucose; Glutathione; Homocysteine; Metabolism; Methionine; Pharmacology; Research; Saccharomyces; Saccharomyces cerevisiae; Sulfates; Sulfides; Sulfur Oxides; Yeast, Dried | 1964 |
STUDIES ON THE FORMATION OF BIOTIN FROM DESTHIOBIOTIN AND SULFATE IN SACCHAROMYCES CEREVISIAE. II. ON SULFUR SOURCES OF BIOTIN FORMATION BY WASHED CELL SUSPENSION OF YEAST.
Topics: Biotin; Choline; Culture Media; Cysteine; Cystine; Ethionine; Glucose; Glutathione; Homocysteine; Metabolism; Methionine; Research; Saccharomyces; Saccharomyces cerevisiae; Sulfates; Sulfur; Sulfur Oxides; Yeast, Dried | 1964 |
THE ROLE OF VITAMIN B12 IN METHIONINE BIOSYNTHESIS IN AVIAN LIVER.
Topics: Amino Acids; Animals; Birds; Coenzymes; Corrinoids; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Liver; Methionine; Poultry; Research; Transferases; Vitamin B 12 | 1964 |
VITAMIN B12 AND THE SYNTHESIS OF THE METHYL GROUPS OF CHOLINE IN OCHROMONAS MALHAMENSIS.
Topics: Alkylation; Carbon Isotopes; Choline; Coenzymes; Eukaryota; Formaldehyde; Formates; Homocysteine; Metabolism; Methionine; Ochromonas; Radiometry; Research; Tritium; Vitamin B 12 | 1964 |
THE ENZYMATIC METHYLATION OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID. V. PURIFICATION AND PROPERTIES OF THE DEOXYRIBONUCLEIC ACID-METHYLATING ACTIVITY OF ESCHERICHIA COLI.
Topics: Alkylation; Carbon Isotopes; Chromatography; Cytosine; DNA; DNA, Bacterial; Enzyme Inhibitors; Escherichia coli; Homocysteine; Methionine; Methylation; Purines; Research; RNA; RNA, Bacterial; Spectrophotometry | 1964 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. IX. TRANSMETHYLATION FROM S-ADENOSYLMETHIONINE AND 5-METHYLTETRAHYDROFOLATE TO 2-MERCAPTOETHANOL AND HOMOCYSTEINE.
Topics: Alkylation; Biological Assay; Carbon Isotopes; Folic Acid; Homocysteine; Kinetics; Lactobacillus; Mercaptoethanol; Methionine; Nucleosides; Research; S-Adenosylmethionine; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolates; Transferases | 1965 |
STUDIES ON METHIONINE BIOSYNTHESIS. EFFECT OF ALKYLCOBAMIDE DERIVATIVES ON THE FORMATION OF HOLOENZYME.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Corrinoids; Dinitrophenols; Enzyme Inhibitors; Escherichia coli; Folic Acid; Holoenzymes; Homocysteine; Light; Metabolism; Methionine; Research; Transferases; Vitamin B 12 | 1965 |
HOMOCYSTINURIA: METABOLIC STUDIES ON 3 PATIENTS.
Topics: Amino Acid Metabolism, Inborn Errors; Blood; Child; Genetics, Medical; Homocysteine; Homocystine; Homocystinuria; Humans; Intellectual Disability; Metabolism; Methionine; Neomycin; Urine | 1965 |
BIOSYNTHESIS OF METHIONINE IN SACCHAROMYCES CEREVISIAE. KINETICS AND MECHANISM OF REACTION OF S-ADENOSYLMETHIONINE:HOMOCYSTEINE METHYLTRANSFERASE.
Topics: Amino Acids; Chromatography; Homocysteine; Homocysteine S-Methyltransferase; Ions; Kinetics; Mercaptoethanol; Methionine; Nucleosides; Research; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Sulfhydryl Compounds; Transferases | 1965 |
THE FORMATION OF CH4 FROM N-5-METHYLTETRAHYDROFOLATE MONOGLUTAMATE BY CELL-FREE EXTRACTS OF METHANOBACILLUS OMELIANSKII.
Topics: Adenosine Triphosphate; Autoradiography; Bacteria; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Glutamates; Homocysteine; Methane; Methionine; Research; Spectrophotometry; Tetrahydrofolates; Vitamin B 12 | 1965 |
The involvement of phosphorylated serine in the conversion of homocysteine to methionine by Streptococcus lactis.
Topics: Butyrates; Homocysteine; Humans; Lactococcus lactis; Lipid Metabolism; Methionine; Phosphorylation; Serine; Streptococcus | 1955 |
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
Topics: Animals; Food; Homocysteine; Liver; Methionine; Transferases | 1961 |
Increased plasma homocysteine and S-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis.
Topics: Child; Cystic Fibrosis; Female; Homocysteine; Humans; Male; Methionine; Phosphatidylcholines; Phosphatidylethanolamines; S-Adenosylhomocysteine; Severity of Illness Index | 2003 |
Polyamine concentrations in the brain of vitamin B12-deficient rats.
Topics: Animals; Brain; Homocysteine; Liver; Male; Methionine; Neurons; Polyamines; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.
Topics: Adult; Carbon; Carbon Isotopes; Female; Folic Acid; Homocysteine; Humans; Leucine; Methionine; Methylation; Reference Values; Serine | 2004 |
Homocysteine inhibits butyrylcholinesterase activity in rat serum.
Topics: Animals; Blood Proteins; Butyrylcholinesterase; Cholinesterase Inhibitors; Homocysteine; Kinetics; Methionine; Rats | 2003 |
Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading.
Topics: Administration, Oral; Adult; Arginine; Homocysteine; Humans; Male; Methionine; Middle Aged; Time Factors | 2003 |
Conversion of homocysteine to methionine by methionine synthase: a density functional study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Homocysteine; Methionine; Models, Molecular; Thermodynamics | 2003 |
Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation.
Topics: Amino Acids; Caco-2 Cells; Culture Media; Epithelial Cells; Folic Acid Deficiency; Homocysteine; Humans; Intestinal Mucosa; Intestines; Kinetics; Methionine; Methylation; Serine | 2004 |
A mathematical model of the methionine cycle.
Topics: Animals; Computational Biology; Cystathionine; Homocysteine; Methionine; Models, Biological; S-Adenosylhomocysteine; S-Adenosylmethionine | 2004 |
All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Animals; Dose-Response Relationship, Drug; Glycine N-Methyltransferase; Homocysteine; Liver; Methionine; Methyltransferases; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Tetrahydrofolates; Time Factors; Tretinoin | 2003 |
The atherogenic effect of excess methionine intake.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Diet; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Models, Biological; Vitamin B 12; Vitamin B 6; Vitamin B Deficiency | 2003 |
Homocysteine altered ROS generation and NO accumulation in endothelial cells.
Topics: Cell Survival; Cells, Cultured; Cysteine; Endothelium, Vascular; Homocysteine; Humans; Methionine; Nitric Oxide; Reactive Oxygen Species; Umbilical Veins | 2003 |
Chronic methionine load-induced hyperhomocysteinemia enhances rat carotid responsiveness for angiotensin II.
Topics: Angiotensin II; Animals; Carotid Arteries; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Homocysteine; In Vitro Techniques; Indomethacin; Male; Methionine; Muscle Contraction; Potassium Chloride; Rats; Rats, Wistar; Vasoconstrictor Agents | 2004 |
Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes.
Topics: Adult; Aged; Cell Death; Cell Division; Cell Nucleus; Cells, Cultured; Culture Media; Female; Folic Acid; Gene Rearrangement; Genomic Instability; Homocysteine; Homozygote; Humans; Lymphocytes; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Micronuclei, Chromosome-Defective; Micronucleus Tests; Middle Aged; Polymorphism, Genetic; Riboflavin | 2004 |
Plasma homocysteine after insulin infusion in type II diabetic patients with and without methionine intolerance.
Topics: Blood Glucose; Cysteine; Diabetes Mellitus, Type 2; DNA; Female; Folic Acid; Glucose Clamp Technique; Homocysteine; Humans; Hyperhomocysteinemia; Insulin; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymerase Chain Reaction; Vitamin B 12; Vitamin B 6 | 2004 |
Spontaneous increase in the rate of formation of methionine from dimethylthetin and homocysteine in rat liver homogenates.
Topics: Animals; Betaine; Glycine; Homocysteine; Liver; Methionine; Rats | 1951 |
The synthesis of methionine from homocysteine by Escherichia coli.
Topics: Cysteine; Escherichia coli; Homocysteine; Methionine | 1952 |
Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Biological Availability; Catalase; Copper; Cysteine; Diet; Dietary Supplements; Glutathione; Homocysteine; Hyperhomocysteinemia; Hypertension; Iron; Liver; Male; Methionine; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2004 |
Release of homocysteic acid from rat thalamus following stimulation of somatosensory afferents in vivo: feasibility of glial participation in synaptic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Homocysteine; Iontophoresis; Kainic Acid; Male; Methionine; N-Methylaspartate; Neuroglia; Physical Stimulation; Piperazines; Rats; Rats, Wistar; Sulfur Isotopes; Synaptic Transmission; Thalamus; Vibrissae | 2004 |
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia.
Topics: Animals; Ascorbic Acid; Blotting, Western; Diet; Folic Acid; Glutathione; Hepatocytes; Homeostasis; Homocysteine; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; tert-Butylhydroperoxide; Tissue Distribution | 2004 |
Methionine metabolism in plants: chloroplasts are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol.
Topics: Arabidopsis; Blotting, Western; Chloroplasts; Cloning, Molecular; Cytosol; Diffusion; DNA, Complementary; Dose-Response Relationship, Drug; Escherichia coli; Green Fluorescent Proteins; Homocysteine; Immunoblotting; Kinetics; Luminescent Proteins; Methionine; Mitochondria; Models, Biological; Molecular Sequence Data; Phylogeny; Pisum sativum; Plastids; Protein Isoforms; S-Adenosylmethionine; Time Factors; Vitamin B 12 | 2004 |
Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats.
Topics: Animals; Antioxidants; Diet; Dioscorea; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Methionine; Oxidative Stress; Platelet Aggregation; Rats; Rats, Sprague-Dawley | 2004 |
Analysis of cell-cycle kinetics and sulfur amino acid metabolism in methionine-dependent tumor cell lines; the effect of homocysteine supplementation.
Topics: Animals; Cell Cycle; Cell Division; Cell Line, Tumor; Homocysteine; Humans; Methionine; Mice; Rats; Sulfur | 2004 |
Young stroke and basal plasma and post-methionine load homocysteine and cysteine levels 1 year after the acute event: do plasma folates make the difference?
Topics: Adult; Case-Control Studies; Cysteine; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methionine; Middle Aged; Stroke; Time Factors; Vitamin B 12 | 2004 |
The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration.
Topics: Adenosylhomocysteinase; Animals; Apolipoproteins E; Brain; Brain Chemistry; Cognition Disorders; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Female; Folic Acid Deficiency; Homocysteine; Male; Methionine; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Tubercidin; Vitamin E Deficiency | 2004 |
Endothelial cell adhesion molecules in healthy adults during acute hyperhomocysteinemia and mild hypertriglyceridemia.
Topics: Acute Disease; Administration, Oral; Adult; Cardiovascular Diseases; Cell Adhesion Molecules; Comorbidity; Dietary Fats; Drug Synergism; Endothelium; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertriglyceridemia; Inflammation; Male; Methionine; Middle Aged; P-Selectin; Risk Factors; Triglycerides | 2004 |
CSF-methionine is elevated in psychotic patients.
Topics: Adult; Biomarkers; Cystathionine; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Psychotic Disorders; Sex Factors | 2004 |
Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice.
Topics: Amino Acids; Animals; Cystathionine beta-Synthase; Homocysteine; Humans; Liver; Methionine; Mice; Mice, Transgenic | 2004 |
Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.
Topics: Betaine; Betaine-Homocysteine S-Methyltransferase; Binding Sites; Catalysis; Enzyme Inhibitors; Glutamic Acid; Homocysteine; Humans; Kinetics; Ligands; Methionine; Methyltransferases; Mutagenesis, Site-Directed; Protein Binding; Sarcosine; Spectrometry, Fluorescence; Substrate Specificity; Tryptophan; Tyrosine | 2004 |
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
Topics: Animal Feed; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta-Synthase; Cysteine; Female; Heterozygote; Homocysteine; Hyperhomocysteinemia; Lipotropic Agents; Liver; Male; Methionine; Methyltransferases; Mice; Mice, Inbred C57BL; Regression Analysis; Serine | 2004 |
Prenatal protein restriction does not affect the proliferation and differentiation of rat preadipocytes.
Topics: Adipocytes; Animals; Animals, Newborn; Blood Vessels; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media; Diet, Protein-Restricted; Epididymis; Female; Fetus; Homocysteine; Kidney; Lactation; Male; Methionine; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Stem Cells; Stromal Cells; Subcutaneous Tissue; Taurine; Weaning | 2004 |
Effect of a methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Body Weight; Bradykinin; Calcium Chloride; Cysteine; Desoxycorticosterone; Dietary Supplements; Glutathione; Homocysteine; Hypertension; Male; Methionine; Nitroprusside; Norepinephrine; Organ Size; Rats; Rats, Sprague-Dawley; Sodium; Vasoconstrictor Agents | 2004 |
Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Coffee; Female; Folic Acid; Germany; Homocysteine; Humans; Life Style; Linear Models; Longitudinal Studies; Male; Methionine; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Sex Characteristics; Smoking; Tea; Vitamin B 12 | 2004 |
The cblD defect causes either isolated or combined deficiency of methylcobalamin and adenosylcobalamin synthesis.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Alkyl and Aryl Transferases; Child; Child, Preschool; Cobamides; DNA, Complementary; Fibroblasts; Genetic Complementation Test; Homocysteine; Homocystinuria; Humans; Male; Methionine; Methylmalonyl-CoA Mutase; Models, Biological; Mutation; Phenotype; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Oxidative stress in mothers who have conceived fetus with neural tube defects: the role of aminothiols and selenium.
Topics: Adult; Case-Control Studies; Cysteine; Dipeptides; Female; Folic Acid; Glutathione; Homocysteine; Humans; Infant, Newborn; Methionine; Mothers; Neural Tube Defects; Oxidation-Reduction; Oxidative Stress; Selenium; Sulfhydryl Compounds | 2004 |
High dietary methionine plus cholesterol exacerbates atherosclerosis formation in the left main coronary artery of rabbits.
Topics: Animal Feed; Animals; Arterioles; Cholesterol, Dietary; Coronary Artery Disease; Coronary Vessels; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rabbits; Risk Factors; Tunica Intima; Tunica Media | 2004 |
Taurine protected myocardial mitochondria injury induced by hyperhomocysteinemia in rats.
Topics: Animals; Anions; Calcium; Calcium-Transporting ATPases; Cardiovascular Diseases; Catalase; Homocysteine; Hydrogen Peroxide; Male; Malondialdehyde; Manganese; Methionine; Microscopy, Electron; Mitochondria; Mitochondria, Heart; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Succinate Dehydrogenase; Superoxide Dismutase; Superoxides; Taurine; Time Factors | 2004 |
Homocysteine increases methionine synthase mRNA level in Caco-2 cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenocarcinoma; Caco-2 Cells; Gene Expression Regulation, Neoplastic; Homocysteine; Humans; Methionine; RNA, Messenger; Transcription, Genetic; Up-Regulation; Vitamin B 12 | 2004 |
Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Arabidopsis; Binding Sites; Cations; Crystallography, X-Ray; Cysteine; Escherichia coli; Folic Acid; Fourier Analysis; Histidine; Homocysteine; Methionine; Methyltransferases; Models, Molecular; Plasmids; Protein Conformation; Protein Structure, Tertiary; Sulfur; Tetrahydrofolates; Vitamin B 12; Zinc | 2004 |
Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adaptation, Physiological; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Cyclosporine; Fluconazole; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Fungal; Homocysteine; Hot Temperature; Melanins; Methionine; Mice; Microbial Sensitivity Tests; Mutation; RNA, Fungal; RNA, Messenger; Tacrolimus; Transcription, Genetic; Virulence; Virulence Factors | 2004 |
Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways.
Topics: Adenosylhomocysteinase; Animals; Bacterial Proteins; Carbon-Sulfur Lyases; Databases, Protein; Genome; Genome, Bacterial; Genome, Fungal; Genome, Human; Genome, Plant; Homocysteine; Homoserine; Humans; Lactones; Methionine; Mice; Phylogeny; Rats; Signal Transduction | 2004 |
Interrelationship between methionine and cystine of early Peking ducklings.
Topics: Animal Feed; Animals; Chromatography, High Pressure Liquid; Colorimetry; Cystine; Diet; Dietary Supplements; Ducks; Eating; Homocysteine; Male; Methionine; Uric Acid; Weight Gain | 2004 |
History of emerging vascular disease risk factors.
Topics: Animals; Arteriosclerosis; Fibrinogen; Fibrinolysis; Homocysteine; Humans; Methionine; Methylation; Review Literature as Topic; Risk Factors | 2004 |
Betaine and folate status as cooperative determinants of plasma homocysteine in humans.
Topics: Adult; Aged; Betaine; Choline; Creatinine; Dose-Response Relationship, Drug; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Sarcosine; Vitamin B 12; Vitamin B 6 | 2005 |
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
Topics: Adenosine; Autistic Disorder; Betaine; Biomarkers; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cysteine; Female; Glutathione; Homocysteine; Humans; Leucovorin; Male; Methionine; Methylation; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 2004 |
Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.
Topics: Animals; Betaine; Disease Models, Animal; Glycine; Homocysteine; Hyperhomocysteinemia; Injections, Intravenous; Male; Methionine; Rats; Sarcosine | 2004 |
The influence of dietary vitamin E, fat, and methionine on blood cholesterol profile, homocysteine levels, and oxidizability of low density lipoprotein in the gerbil.
Topics: Animals; Blood Proteins; Body Weight; Cholesterol; Dietary Fats; Eating; Gerbillinae; Homocysteine; Lipid Peroxidation; Lipoproteins, LDL; Male; Methionine; Nutritional Status; Vitamin E | 2004 |
Effect of folic acid on methionine and homocysteine metabolism in end-stage renal disease.
Topics: Administration, Oral; Adult; Aged; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kinetics; Male; Methionine; Methylation; Middle Aged; Renal Dialysis | 2005 |
Relevance of post-methionine homocysteine and lipoprotein (a) in evaluating the cardiovascular risk in young CAD patients.
Topics: Adult; Biomarkers; Blood Coagulation; Case-Control Studies; Chelating Agents; Coronary Disease; Fasting; Female; Folic Acid Deficiency; Homocysteine; Humans; Lipoprotein(a); Male; Methionine; Middle Aged; Risk; Statistics, Nonparametric; Thromboplastin; Vitamin B 12 Deficiency | 2005 |
Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism.
Topics: Adult; Arkansas; Biomarkers; Case-Control Studies; Female; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Life Style; Methionine; Pregnancy; Registries; Risk Factors; S-Adenosylhomocysteine | 2005 |
Insulin in methionine and homocysteine kinetics in healthy humans: plasma vs. intracellular models.
Topics: Blood Glucose; Breath Tests; Glucose Clamp Technique; Homocysteine; Humans; Hyperinsulinism; Insulin; Isoenzymes; Kinetics; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Radioisotope Dilution Technique | 2005 |
Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects.
Topics: Adult; Amino Acids; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Methylation; Middle Aged; Vitamins | 2005 |
Transcriptional responses of Escherichia coli to S-nitrosoglutathione under defined chemostat conditions reveal major changes in methionine biosynthesis.
Topics: Bacterial Proteins; Dihydropteridine Reductase; DNA, Complementary; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Glycerol; Hemeproteins; Homocysteine; Methionine; Models, Biological; NADH, NADPH Oxidoreductases; Nitric Oxide; Nitrogen; Nucleic Acid Hybridization; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Nitrosoglutathione; Signal Transduction; Succinate Dehydrogenase; Time Factors; Transcription, Genetic; Up-Regulation | 2005 |
Effects of dietary supplements of folic acid and rumen-protected methionine on lactational performance and folate metabolism of dairy cows.
Topics: Animals; Cattle; Cysteine; Diet; Dietary Supplements; Female; Folic Acid; Hemoglobins; Homocysteine; Kinetics; Lactation; Methionine; Milk; Rumen; Vitamin B 12 | 2005 |
Effects of intramuscular injections of vitamin B12 on lactation performance of dairy cows fed dietary supplements of folic acid and rumen-protected methionine.
Topics: Animals; Cattle; Cysteine; Diet; Dietary Supplements; Eating; Female; Folic Acid; Homocysteine; Injections, Intramuscular; Lactation; Methionine; Methylmalonic Acid; Milk; Parity; Rumen; Vitamin B 12 | 2005 |
Design and synthesis of heterobimetallic donor-acceptor chemodosimetric ensembles for the detection of sulfhydryl-containing amino acids and peptides.
Topics: Binding, Competitive; Crystallography, X-Ray; Cysteine; Fluorometry; Glutathione; Homocysteine; Methionine; Models, Chemical; Molecular Conformation; Molecular Structure; Organometallic Compounds; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds | 2005 |
L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice.
Topics: Animals; Apolipoproteins E; Arginine; Arteriosclerosis; Cell Line; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocysteine; Methionine; Methylation; Mice; Mice, Knockout; Models, Biological; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine; Risk Factors; Time Factors | 2004 |
Expression profiling of homocysteine junction enzymes in the NCI60 panel of human cancer cell lines.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cystathionine beta-Synthase; Ferredoxin-NADP Reductase; Gene Expression Profiling; Homocysteine; Humans; Methionine; NADPH-Ferrihemoprotein Reductase; Neoplasms | 2005 |
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.
Topics: Adult; Carbon Isotopes; Deuterium; Female; Glycine; Homocysteine; Humans; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pyridoxal Phosphate; Serine; Vitamin B 6 | 2005 |
Homocysteine levels--before and after methionine loading--in 51 Dutch families.
Topics: Adult; Female; Genotype; Homocysteine; Humans; Inheritance Patterns; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Models, Genetic; Netherlands; Pedigree; Polymorphism, Genetic; Regression Analysis; Risk Factors | 2005 |
Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis.
Topics: Analysis of Variance; Animals; Bile Ducts; Cholestasis; Cysteine; Glutathione; Homocysteine; Ligation; Liver; Liver Cirrhosis, Biliary; Male; Methionine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 2005 |
Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes.
Topics: Aged; Cystathionine; Cysteine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Male; Methionine; Methylmalonic Acid; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcobalamins; Vitamin B 12; Vitamin B 6 | 2005 |
Creatine metabolism in combined methylmalonic aciduria and homocystinuria.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Creatine; Female; Glycine; Homocysteine; Homocystinuria; Humans; Male; Methionine; Methylmalonic Acid; Vitamin B 12 | 2005 |
A pulsed potential waveform displaying enhanced detection capabilities towards sulfur-containing compounds at a gold working electrode.
Topics: Acetylcysteine; Biotin; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cysteine; Cystine; Electrochemistry; Electrodes; Glutathione; Gold; Homocysteine; Methionine; Oxidation-Reduction; Reproducibility of Results; Sensitivity and Specificity; Sulfur Compounds; Thioctic Acid | 2005 |
Methimazole-induced hypothyroidism paradoxically decreases homocysteine.
Topics: Adolescent; Adult; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Hypothyroidism; Lipids; Logistic Models; Male; Methimazole; Methionine; Plasminogen Activator Inhibitor 1; Thyrotropin; Vitamin B 12; Vitamin B 6 | 2005 |
Synthesis of autoinducer 2 by the lyme disease spirochete, Borrelia burgdorferi.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bacterial Proteins; Blotting, Western; Borrelia burgdorferi; Carbon-Sulfur Lyases; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Bacterial; Homocysteine; Homoserine; Lactones; Methionine; N-Glycosyl Hydrolases; Pentanes; RNA, Bacterial; RNA, Messenger; Transcription, Genetic | 2005 |
Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.
Topics: Adult; Amino Acids; Female; Folic Acid; Folic Acid Deficiency; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Leucine; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Serine | 2005 |
von Willebrand factor multimer composition is modified following oral methionine load in women with thrombosis, but not in healthy women.
Topics: Adult; Case-Control Studies; Dimerization; Female; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Middle Aged; Peptide Fragments; Peptide Hydrolases; Thrombosis; von Willebrand Factor | 2005 |
Rosiglitazone reduces serum homocysteine levels, smooth muscle proliferation, and intimal hyperplasia in Sprague-Dawley rats fed a high methionine diet.
Topics: Animals; Carotid Arteries; Catheterization; Cell Division; Cystathionine beta-Synthase; Diet; DNA; Female; Homocysteine; Hyperplasia; Ligands; Liver; Methionine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; PPAR gamma; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones; Tunica Intima | 2005 |
Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; Excitatory Amino Acid Antagonists; Glycine; Homocysteine; In Vitro Techniques; Injections, Intraperitoneal; Kynurenic Acid; Leucine; Male; Methionine; Phenylalanine; Pipecolic Acids; Rats; Rats, Wistar; Risk Factors; S-Adenosylhomocysteine | 2005 |
Analysis of pathological defects in methionine metabolism using a simple mathematical model.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Cystathionine beta-Synthase; Glycine N-Methyltransferase; Homocysteine; Humans; Liver; Methionine; Methionine Adenosyltransferase; Models, Biological; Mutation | 2005 |
Homocysteine toxicity in Escherichia coli is caused by a perturbation of branched-chain amino acid biosynthesis.
Topics: Amino Acids, Branched-Chain; Culture Media; Escherichia coli; Gene Expression Regulation, Bacterial; Homocysteine; Isoleucine; Methionine; Threonine Dehydratase | 2005 |
Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model.
Topics: Animals; Cystathionine beta-Synthase; Genotype; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutagenesis, Site-Directed; Phenotype | 2005 |
Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alcoholism; Avitaminosis; Comorbidity; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methionine; Methylation; Middle Aged; Prevalence | 2005 |
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
Topics: Animals; Diet; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Pregnancy | 2005 |
Purification and characterization of mouse hepatic enzyme that converts selenomethionine to methylselenol by its alpha,gamma-elimination.
Topics: Aging; Ammonium Sulfate; Animals; Brain; Carbon-Sulfur Lyases; Catalysis; Chromatography; Female; Homocysteine; Homoserine; Humans; Intestine, Large; Kinetics; Liver; Male; Methanol; Methionine; Mice; Mice, Inbred ICR; Muscles; Organoselenium Compounds; Selenium; Selenomethionine; Substrate Specificity; Temperature | 2005 |
Evolutionary plasticity of methionine biosynthesis.
Topics: Arabidopsis; Archaea; Bacteria; Evolution, Molecular; Homocysteine; Homoserine; Methionine; Methylation; Models, Biological; Saccharomyces; Schizosaccharomyces | 2005 |
Maculopathy and retinal degeneration in cobalamin C methylmalonic aciduria and homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Betaine; Cobamides; Female; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Infant; Macula Lutea; Methionine; Methylmalonic Acid; Retina; Retinal Degeneration; Vision, Ocular; Visual Acuity; Vitamin B 12 Deficiency | 2005 |
Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry.
Topics: Amino Acids; Autoanalysis; Formates; Gas Chromatography-Mass Spectrometry; Glycine; Homocysteine; Humans; Indicators and Reagents; Methionine; Methylmalonic Acid; Plasma; Reference Values; Sensitivity and Specificity; Serine; Serum | 2005 |
Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS.
Topics: Animals; Astrocytes; Brain; Bromodeoxyuridine; Cell Lineage; Central Nervous System; Cerebellum; Cerebral Cortex; Corpus Callosum; Cyclic AMP; Cystathionine beta-Synthase; Dexamethasone; Epidermal Growth Factor; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glucocorticoids; Heterozygote; Hippocampus; Homocysteine; Homocystinuria; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Ligands; Methionine; Mice; Mice, Transgenic; Microscopy, Fluorescence; Models, Biological; Neuroglia; Olfactory Bulb; Oxidative Stress; Transforming Growth Factor alpha; Up-Regulation | 2005 |
[Folate reduces monocyte chemoattractant protein-1 expression in rats with hyperhomocysteinemia].
Topics: Animals; Aorta; Chemokine CCL2; Endothelium, Vascular; Folic Acid; Homocysteine; Hyperhomocysteinemia; Leukocytes, Mononuclear; Male; Methionine; Random Allocation; Rats; Rats, Sprague-Dawley | 2005 |
Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by methionine intake.
Topics: Animals; Antioxidants; Brain; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2005 |
Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy.
Topics: Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fasting; Food; Glucose Clamp Technique; Glycated Hemoglobin; Heterozygote; Homocysteine; Homozygote; Humans; Insulin; Kinetics; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Sulfur | 2005 |
Performance comparison of three assay methods used in fasting and postmethionine load plasma homocysteine determinations from patients with vascular disease.
Topics: Aged; Chromatography, High Pressure Liquid; Fasting; Female; Fluorescence Polarization Immunoassay; Homocysteine; Humans; Male; Methionine; Middle Aged; Regression Analysis; Vascular Diseases | 2005 |
Homocysteine metabolism in ZDF (type 2) diabetic rats.
Topics: Animals; Betaine; Cells, Cultured; Diabetes Mellitus, Type 2; Gene Expression Regulation, Enzymologic; Hepatocytes; Homocysteine; Insulin Resistance; Liver; Methionine; Phosphatidylcholines; Rats; Rats, Zucker; RNA, Messenger | 2005 |
Homocysteine and cognition--no longer a hypothesis?
Topics: Aged; Alzheimer Disease; Cognition; Cognition Disorders; Homocysteine; Humans; Methionine; Models, Biological; Models, Theoretical; Neurodegenerative Diseases; Vitamin B 12; Vitamins | 2006 |
Homocysteine and coronary microcirculation: is it a microvasculopathic agent?
Topics: Administration, Oral; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2006 |
Liver failure and neurologic disease in a patient with homocystinuria.
Topics: Adult; Homocysteine; Homocystinuria; Humans; Liver Failure; Liver Transplantation; Male; Methionine; Nervous System Diseases | 2006 |
Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats.
Topics: Analysis of Variance; Animals; Cholesterol; Dose-Response Relationship, Drug; Feces; Homocysteine; Hydroxymethylglutaryl CoA Reductases; Lipid Metabolism; Lipoproteins; Male; Methionine; Random Allocation; Rats; Rats, Sprague-Dawley | 2006 |
Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxal Phosphate; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2006 |
Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast.
Topics: Basic-Leucine Zipper Transcription Factors; Culture Media, Conditioned; Cysteine; Fungal Proteins; Gene Expression Regulation, Fungal; Glutathione; Glycolysis; Homocysteine; HSP70 Heat-Shock Proteins; Methionine; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sulfhydryl Compounds | 2006 |
Methionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases.
Topics: Adult; Child, Preschool; Diagnosis, Differential; Female; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Mutation; Mutation, Missense | 2005 |
Homocysteine accumulation causes a defect in purine biosynthesis: further characterization of Schizosaccharomyces pombe methionine auxotrophs.
Topics: Gene Expression Regulation, Fungal; Homocysteine; Homocystine; Methionine; Purines; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2006 |
Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blotting, Western; Cardiovascular Diseases; Case-Control Studies; Cells, Cultured; Chromatography, High Pressure Liquid; Copper; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Lipoproteins, LDL; Male; Methionine; Middle Aged; Nitrites; Osteoarthritis; Receptors, Scavenger; Tyrosine; Umbilical Veins | 2006 |
Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation and superoxide formation in the aorta of the rabbit.
Topics: Acetophenones; Acetylcholine; Administration, Oral; Animals; Aorta; Blotting, Western; Cyclic GMP; Dietary Supplements; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Methionine; NADPH Oxidases; Nitric Oxide Donors; Nitroprusside; Onium Compounds; Penicillamine; Rabbits; Superoxides; Time Factors; Vasodilation; Vasodilator Agents | 2006 |
Is homocysteine an iron-dependent cardiovascular risk factor?
Topics: Adult; Cardiovascular Diseases; Chelating Agents; Endothelium, Vascular; Female; Ferritins; Homocysteine; Humans; Iron; Iron Deficiencies; Male; Methionine; Oxidative Stress; Razoxane; Regional Blood Flow; Risk Factors; Sex Characteristics; Vasodilation | 2006 |
Methionine kinetics are altered in the elderly both in the basal state and after vaccination.
Topics: Adult; Aged; Aging; Carbon Isotopes; Cysteine; Deuterium; Female; Homocysteine; Humans; Inflammation; Isotope Labeling; Male; Mathematics; Methionine; Methylation; Nutritional Requirements; Postprandial Period; Vaccination | 2006 |
High dietary methionine intake increases the risk of acute coronary events in middle-aged men.
Topics: Acute Disease; Adult; Cohort Studies; Coronary Disease; Diet Records; Dietary Proteins; Finland; Follow-Up Studies; Homocysteine; Humans; Male; Methionine; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Factors | 2006 |
No added value of the methionine loading task in assessment for venous thrombosis and cardiovascular disease risk.
Topics: Aged; Cardiovascular Diseases; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Practice Guidelines as Topic; Risk; ROC Curve; Venous Thrombosis | 2006 |
Effect of dietary methionine on plasma and liver cholesterol concentrations in rats and expression of hepatic genes involved in cholesterol metabolism.
Topics: Amino Acids; Animals; Bile Acids and Salts; Cells, Cultured; Cholesterol; Diet; Eating; Feces; Gene Expression Regulation; Hepatocytes; Homocysteine; Lipid Metabolism; Lipids; Liver; Male; Methionine; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Sprague-Dawley; Receptors, LDL; RNA, Messenger; Weight Gain | 2006 |
Is elevated post-methionine load homocysteinaemia a risk factor for cervical artery dissection?
Topics: Adult; Carotid Artery, Internal; Carotid Artery, Internal, Dissection; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Methionine; Risk Factors; Up-Regulation; Vertebral Artery Dissection | 2006 |
Comparative species utilization and toxicity of sulfur amino acids.
Topics: Alanine; Amino Acids, Sulfur; Animals; Biological Availability; Cysteine; Cystine; Dietary Supplements; Glutathione; Homocysteine; Humans; Hydroxylation; Isomerism; Methionine; Species Specificity; Sulfides; Taurine; Vitamin U | 2006 |
The 5th workshop on the assessment of adequate intake of dietary amino acids: general discussion 1.
Topics: Amino Acids; Animals; Creatine; Cysteine; Diet; Glutathione; Homocysteine; Humans; Methionine; Nutritional Requirements; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Screening of toxicity biomarkers for methionine excess in rats.
Topics: Amino Acids; Analysis of Variance; Animals; Bilirubin; Biomarkers; Cystathionine; Diet; Gas Chromatography-Mass Spectrometry; Glycine; Hemolysis; Homocysteine; Iron; Male; Methionine; Rats; Rats, Inbred F344; Serine; Spleen | 2006 |
Pathophysiological consequences of homocysteine excess.
Topics: Autoantibodies; Blood Proteins; Cell Death; Diet; Endoplasmic Reticulum; Homocysteine; Humans; Hyperhomocysteinemia; Lysine; Methionine; Protein Binding | 2006 |
The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy?
Topics: Adult; Cross-Sectional Studies; Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Hypersensitivity; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymorphism, Genetic; Riboflavin; Risk Assessment; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6 | 2006 |
Effects of insulin deprivation and treatment on homocysteine metabolism in people with type 1 diabetes.
Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus, Type 1; Female; Homocysteine; Humans; Insulin; Male; Methionine; Middle Aged | 2006 |
The effect of in vitro homocystinuria on the suckling rat hippocampal acetylcholinesterase.
Topics: Acetylcholinesterase; Amino Acids, Sulfur; Animals; Animals, Suckling; Electrophorus; Enzyme Activation; Hippocampus; Homocysteine; Homocystine; Homocystinuria; In Vitro Techniques; Methionine; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar | 2006 |
Changes in atrium and thoracic aorta reactivity to adenosinergic and adrenergic agonists in experimental hyperhomocysteinemia.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Blood Pressure; Dipyridamole; Heart Atria; Heart Rate; Homocysteine; Hyperhomocysteinemia; Isoproterenol; Male; Methionine; Phenylephrine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Theophylline; Vasoconstriction; Vasodilation | 2006 |
Distinct effects of folate and choline deficiency on plasma kinetics of methionine and homocysteine in rats.
Topics: Animals; Choline Deficiency; Folic Acid Deficiency; Homocysteine; Kinetics; Male; Methionine; Methylation; Rats; Rats, Sprague-Dawley | 2006 |
Investigation of bioisosteric effects on the interaction of substrates/ inhibitors with the methionyl-tRNA synthetase from Escherichia coli.
Topics: Adenosine; Adenosine Monophosphate; Anti-Bacterial Agents; Enzyme Inhibitors; Escherichia coli; Homocysteine; Methionine; Methionine-tRNA Ligase; Organophosphonates; Phosphinic Acids; Protein Conformation; Stereoisomerism; Substrate Specificity | 2005 |
Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study.
Topics: Aged; Cohort Studies; Cystathionine beta-Synthase; Female; Folic Acid; Heterozygote; Homocysteine; Humans; Male; Methionine; Middle Aged; Minisatellite Repeats; Nuclear Family; Vitamin B 12; Vitamin B 6 | 2006 |
Hyperhomocysteinemia increases arterial permeability and stiffness in mice.
Topics: Animals; Arteries; Atherosclerosis; Capillary Permeability; Elasticity; Endothelium, Vascular; Homocysteine; Hyperhomocysteinemia; Lipoproteins; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide; Superoxides; Vascular Resistance | 2006 |
A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders.
Topics: Androgens; Autistic Disorder; Biomarkers; Child; Child, Preschool; Cystathionine; Cysteine; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Glutathione; Homocysteine; Humans; Male; Methionine; Models, Biological; Signal Transduction; Sulfurtransferases; Testosterone | 2006 |
Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals.
Topics: Adipose Tissue; Adult; Body Composition; Body Water; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male; Menopause; Methionine; Middle Aged; Muscle, Skeletal; Risk Factors; Sex Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Aminothiols in human brain tumors.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Chromatography, Gas; Cysteine; Female; Homocysteine; Humans; Male; Methionine; Middle Aged | 2006 |
Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats.
Topics: Adenine; Animals; Cystathionine beta-Synthase; Diet; Dose-Response Relationship, Drug; Enzyme Activation; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 2006 |
The chemical synthesis of the GstI protein by NCL on a X-Met site.
Topics: Amino Acid Sequence; Bacterial Proteins; Chromatography, High Pressure Liquid; Circular Dichroism; Cysteine; Homocysteine; Mass Spectrometry; Methionine; Protein Structure, Secondary; Repressor Proteins | 2006 |
Folate, the methionine cycle, and Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Reactive Oxygen Species; S-Adenosylmethionine | 2006 |
System b0,+ and the transport of thiol-s-conjugates of methylmercury.
Topics: Amino Acid Transport Systems; Animals; Arginine; Biological Transport; Cysteine; Female; Homocysteine; Methionine; Methylmercury Compounds; Xenopus laevis | 2006 |
Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome.
Topics: Adult; Biomarkers; Cerebrovascular Disorders; Chelating Agents; Coronary Disease; Female; Homocysteine; Humans; Male; Metabolic Syndrome; Methionine; Middle Aged; Peripheral Vascular Diseases; Proportional Hazards Models; Risk Assessment | 2007 |
Effects of chronic betaine ingestion on methionine-loading induced plasma homocysteine elevation in rats.
Topics: Analysis of Variance; Animals; Area Under Curve; Betaine; Betaine-Homocysteine S-Methyltransferase; Carnitine; Choline; Gastrointestinal Agents; Homocysteine; Injections, Intravenous; Liver; Male; Methionine; Rats; Rats, Wistar; Time Factors | 2006 |
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
Topics: Betaine; Carbon; DNA Methylation; Folic Acid; Formate-Tetrahydrofolate Ligase; Homocysteine; Humans; Kinetics; Mathematics; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Molecular Biology; Nutritional Physiological Phenomena; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polymorphism, Genetic; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2006 |
Low fasting methionine concentration as a novel risk factor for recurrent venous thrombosis.
Topics: Adult; Aged; Case-Control Studies; Cysteine; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Middle Aged; Multivariate Analysis; Odds Ratio; Recurrence; Risk Assessment; Risk Factors; Venous Thrombosis | 2006 |
Conversion of methionine to cysteine in Bacillus subtilis and its regulation.
Topics: Bacillus subtilis; Bacterial Proteins; Carbon-Oxygen Lyases; Cystathionine; Cystathionine beta-Synthase; Cysteine; Gene Expression Regulation, Bacterial; Genes, Bacterial; Homocysteine; Lyases; Methionine; Operon; Promoter Regions, Genetic; Serine; Substrate Specificity | 2007 |
Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline.
Topics: Adaptation, Physiological; Animals; Area Under Curve; Arginine; Blood Pressure; Choline; Dietary Proteins; Dietary Supplements; Folic Acid; Homocysteine; Male; Methionine; Methylation; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Time Factors | 2006 |
Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice.
Topics: Animals; Apolipoproteins E; Body Weight; Cholesterol; Disease Susceptibility; Endothelium, Vascular; Gene Expression Regulation; Homocysteine; Hypercholesterolemia; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Knockout; Platelet Activation; Thrombosis | 2007 |
Simultaneous quantitation of homocysteine, cysteine and methionine in plasma and urine by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Cysteine; Cystine; Homocysteine; Humans; Methionine; Reproducibility of Results; Tandem Mass Spectrometry | 2006 |
Sulfur amino acid metabolism in children with severe childhood undernutrition: methionine kinetics.
Topics: Amino Acids, Sulfur; Carbon Isotopes; Case-Control Studies; Edema; Female; Glutathione; Homocysteine; Humans; Infant; Infant Nutrition Disorders; Infections; Kwashiorkor; Male; Methionine; Methylation; Protein Biosynthesis; Protein-Energy Malnutrition; Proteins | 2006 |
Methionine-loading and random homocysteine tests have no added value in risk assessment for venous and arterial thrombosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Cohort Studies; Fasting; Female; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Male; Methionine; Middle Aged; Netherlands; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Time Factors; Venous Thrombosis | 2007 |
Effect of vitamin B6 deficiency on S-adenosylhomocysteine hydrolase activity as a target point for methionine metabolic regulation.
Topics: Adenosylhomocysteinase; Analysis of Variance; Animals; Body Weight; Homocysteine; Liver; Male; Methionine; Random Allocation; Rats; Rats, Wistar; S-Adenosylhomocysteine; Vitamin B Deficiency | 2006 |
Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Animals; Arabidopsis; Caenorhabditis elegans; Drosophila melanogaster; Homocysteine; Homocysteine S-Methyltransferase; Kinetics; Methionine; Methyltransferases; Mice; Molecular Sequence Data; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2007 |
Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice.
Topics: Administration, Oral; Animal Feed; Animals; Catechin; Cystathionine beta-Synthase; DNA Primers; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA; Superoxide Dismutase; Superoxide Dismutase-1 | 2007 |
Methylenetetrahydrofolate reductase gene polymorphisms in Burkina Faso: impact on plasma fasting homocysteine and after methionine loading test.
Topics: Adult; Age Factors; Aged; Burkina Faso; Fasting; Female; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Statistics, Nonparametric | 2007 |
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.
Topics: Animals; Cystathionine beta-Synthase; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mutation | 2007 |
Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis.
Topics: Adolescent; Child; Child, Preschool; Choline; Cystic Fibrosis; Dietary Supplements; Female; Glutathione; Glutathione Disulfide; Homocysteine; Humans; Male; Methionine; Phosphatidylcholines | 2007 |
Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract.
Topics: Animals; Carbon Isotopes; Cystathionine beta-Synthase; DNA Primers; Gastrointestinal Tract; Homocysteine; Methionine; Methylation; Reverse Transcriptase Polymerase Chain Reaction; Statistics, Nonparametric; Sulfur Compounds; Sus scrofa; Tritium | 2007 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Hyperhomocysteinemia and low methionine stress are risk factors for central retinal venous occlusion in an Indian population.
Topics: Adult; Case-Control Studies; Cysteine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Methionine; Prevalence; Prospective Studies; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2007 |
Podocyte injury and glomerulosclerosis in hyperhomocysteinemic rats.
Topics: Actinin; Albuminuria; Animals; Creatinine; Glomerulosclerosis, Focal Segmental; Homocysteine; Hyperhomocysteinemia; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Methionine; Microfilament Proteins; Podocytes; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study.
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Case-Control Studies; Creatinine; DNA Mutational Analysis; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Retrospective Studies; Risk Assessment; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B 6 Deficiency | 2007 |
Plasma amino acids and neopterin in healthy persons with Down's syndrome.
Topics: Aged; Amino Acid Metabolism, Inborn Errors; Amino Acids; Biomarkers; Comorbidity; Dopamine; Down Syndrome; Female; Homocysteine; Homovanillic Acid; Humans; Immune System Diseases; Immunity, Cellular; Male; Methionine; Middle Aged; Neopterin; Taurine; Up-Regulation | 2007 |
Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects.
Topics: Betaine; Dietary Supplements; Folic Acid; Homocysteine; Homocystinuria; Humans; Methionine; Methylation; Neural Tube Defects; Nutritional Physiological Phenomena; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2007 |
Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats.
Topics: Animals; Biomarkers; Dietary Supplements; DNA Methylation; Folic Acid; Homocysteine; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamins; Weaning | 2007 |
Dietary selenium affects homocysteine metabolism differently in Fisher-344 rats and CD-1 mice.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cysteine; Diet; Glutamate-Cysteine Ligase; Glutathione; Glycine N-Methyltransferase; Homocysteine; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Selenium; Species Specificity; Sulfur | 2007 |
Cystathionine beta synthase participates in murine oocyte maturation mediated by homocysteine.
Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Cystathionine beta-Synthase; Female; Granulosa Cells; Homocysteine; Methionine; Mice; Mice, Inbred ICR; Oocytes; Oogenesis; Paracrine Communication; RNA Interference; RNA, Small Interfering; Time Factors; Tissue Culture Techniques; Transfection | 2007 |
Acute variations in homocysteine levels are related to creatine changes induced by physical activity.
Topics: Adult; Arginine; Creatine; Exercise Test; Glycine; Homocysteine; Humans; Male; Methionine; Ornithine; Physical Exertion; Physical Fitness | 2007 |
Characteristics of methionine production by an engineered Corynebacterium glutamicum strain.
Topics: Bacterial Proteins; Corynebacterium glutamicum; Ethionine; Gene Expression Regulation, Bacterial; Homocysteine; Lysine; Methionine; Mutation; Threonine | 2007 |
Hyper-homocysteinemia alters amyloid peptide-clusterin interactions and neuroglial network morphology and function in the caudate after intrastriatal injection of amyloid peptides.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Benzothiazoles; Caudate Nucleus; Clusterin; Drug Interactions; Food, Formulated; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Models, Biological; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazoles | 2007 |
Control of methionine synthesis and uptake by MetR and homocysteine in Streptococcus mutans.
Topics: Bacterial Proteins; Base Sequence; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Bacterial; Homocysteine; Methionine; Models, Biological; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Sequence Homology, Nucleic Acid; Streptococcus mutans; Trans-Activators; Transcription, Genetic | 2007 |
Lowering methylation demand by creatine supplementation paradoxically decreases DNA methylation.
Topics: Animals; Creatine; DNA Methylation; DNA Modification Methylases; Homocysteine; Methionine; Rats; Rats, Wistar | 2007 |
Effect of hyperhomocysteinemia on cardiovascular risk factors and initiation of atherosclerosis in Wistar rats.
Topics: Animals; Aorta; Atherosclerosis; C-Reactive Protein; Cardiovascular Diseases; Caveolin 2; Cholesterol; Cysteine; Homocysteine; Hydroxymethylglutaryl CoA Reductases; Hyperhomocysteinemia; In Vitro Techniques; Leukotrienes; Liver; Male; Methionine; Nitric Oxide; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2Y2; Resistin; Tunica Media | 2007 |
Dietary methionine effects on plasma homocysteine and HDL metabolism in mice.
Topics: Animals; Apolipoproteins E; Cholesterol, HDL; Diet; Homocysteine; Lipoproteins, HDL; Male; Methionine; Mice; Mice, Inbred C57BL | 2008 |
Experimental hyperhomocysteinemia disturbs bone metabolism in rats.
Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Collagen Type I; Creatine; Female; Folic Acid; Homocysteine; Hydroxyproline; Hyperhomocysteinemia; Methionine; Osteocalcin; Osteogenesis; Peptides; Rats; Rats, Wistar; Vitamin B 12 | 2007 |
Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells.
Topics: Animals; Cell Adhesion Molecules; Cells, Cultured; Collagen Type I; Cystathionine beta-Synthase; Endothelial Cells; Extracellular Matrix; Genetic Therapy; Homocysteine; Hyperhomocysteinemia; Inflammation Mediators; Matrix Metalloproteinase 9; Methionine; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Transfection; Tubercidin | 2007 |
Effect of homocysteine on bone mineral density of rats.
Topics: Absorptiometry, Photon; Animals; Bone Density; Chromatography, High Pressure Liquid; Homocysteine; Male; Methionine; Rats; Rats, Wistar; Time Factors | 2007 |
Oral challenge with a methionine load in patients with inflammatory bowel disease: a better test to identify hyperhomocysteinemia.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Inflammatory Bowel Diseases; Male; Methionine; Middle Aged; Prevalence; Prognosis; Prospective Studies; Risk Factors; Thrombosis; Vitamin B 12 | 2008 |
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Topics: Alanine Transaminase; Animals; ATPases Associated with Diverse Cellular Activities; Chromosome Mapping; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Female; Gene Expression; Gene Expression Profiling; Glycine N-Methyltransferase; Glycogen; Glycogen Storage Disease; Hepatitis, Chronic; Homocysteine; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Homocysteine induces connective tissue growth factor expression in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Connective Tissue Growth Factor; Gene Expression Regulation; Homocysteine; Humans; Hyperhomocysteinemia; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Methionine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Umbilical Veins | 2008 |
Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-kappaB activation.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Kidney Tubules, Proximal; Male; Methionine; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2008 |
Does amino acid-based peritoneal dialysate change homocysteine metabolism in continuous ambulatory peritoneal dialysis patients?
Topics: Adolescent; Adult; Aged; Amino Acids; Female; Hemodialysis Solutions; Homocysteine; Humans; Male; Methionine; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Young Adult | 2003 |
Modulation of erythrocyte sensitivity to oxidative stress by transient hyperhomocysteinemia in healthy subjects and in patients with coronary artery disease.
Topics: Adult; Aged; alpha-Tocopherol; Analysis of Variance; Area Under Curve; Coronary Artery Disease; Erythrocytes; Female; Homocysteine; Humans; Hyperhomocysteinemia; Lipid Peroxidation; Male; Methionine; Middle Aged; Oxidation-Reduction; Oxidative Stress | 2008 |
Isolation of a homocysteine gamma-lyase-producing bacterium and study of its enzyme production conditions.
Topics: Bacteriological Techniques; Biomass; Bioreactors; Carbon; Enzyme Stability; Homocysteine; Hydrogen-Ion Concentration; Lyases; Methionine; Nitrogen; Pyridoxal Phosphate; Serratia; Soil Microbiology; Stimulation, Chemical | 2008 |
Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats.
Topics: Animals; Aorta, Thoracic; Cell Line; Cells, Cultured; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; In Vitro Techniques; Male; Methionine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides | 2007 |
The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats.
Topics: Acetylcholine; Animals; Disease Models, Animal; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Liver; Liver Circulation; Liver Cirrhosis; Male; Methionine; Microcirculation; Rats; Rats, Wistar | 2008 |
Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.
Topics: Adiponectin; Adipose Tissue; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Homocysteine; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats; Rats, Sprague-Dawley | 2008 |
Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Body Weight; Diet; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Male; Methionine; Mice; S-Adenosylhomocysteine; Vitamin B 12; Vitamin B 6 | 2008 |
Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study.
Topics: Adult; Betaine; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methionine; Parturition; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, Third; Seychelles; Vitamin B 12; Vitamin B Complex | 2008 |
Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.
Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet; Homocysteine; Hyperhomocysteinemia; Male; Mesenteric Arteries; Methionine; Rats; Rats, Wistar; Vasodilation | 2008 |
Nutritional determinants of plasma homocysteine.
Topics: Adult; Body Weight; Diet, Vegetarian; Homocysteine; Humans; Methionine; Vitamin B 12 Deficiency | 2007 |
Methionine loading does not enhance the predictive value of homocysteine serum testing for all-cause mortality or major adverse cardiac events.
Topics: Adult; Female; Heart Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Predictive Value of Tests | 2009 |
Psychosis, paraplegia and coma revealing methylenetetrahydrofolate reductase deficiency in a 56-year-old woman.
Topics: Brain; Brain Diseases, Metabolic, Inborn; Catatonia; Chromosome Aberrations; Chromosomes, Human, Pair 1; Coma; Dementia; Exons; Folic Acid; Genes, Recessive; Homocysteine; Humans; Magnetic Resonance Imaging; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Neurologic Examination; Paraplegia; Polymorphism, Genetic; Psychotic Disorders | 2008 |
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.
Topics: Animals; Atherosclerosis; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Female; Homocysteine; Hyaluronic Acid; Hyperhomocysteinemia; Immunohistochemistry; Lipids; Methionine; Mice; Mice, Inbred C57BL | 2008 |
Riboswitches that sense S-adenosylhomocysteine and activate genes involved in coenzyme recycling.
Topics: 5' Untranslated Regions; Base Sequence; Binding Sites; Coenzymes; Conserved Sequence; Gene Expression Regulation; Homocysteine; Kinetics; Methionine; Nucleic Acid Conformation; RNA; RNA, Bacterial; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Sensitivity and Specificity | 2008 |
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Folic Acid; Gene Expression; Homocysteine; Humans; Methionine; Mice; Mice, Transgenic; Recombinant Proteins | 2008 |
Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: diagnosis in an expanded neonatal screening programme.
Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Child Development; Child, Preschool; Early Diagnosis; Female; Genetic Predisposition to Disease; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methionine; Methionine Adenosyltransferase; Mutation; Neonatal Screening; Pedigree; Phenotype; Predictive Value of Tests; Prognosis; Spain; Tandem Mass Spectrometry; Up-Regulation | 2008 |
Immunohistochemical detection of N-homocysteinylated proteins in humans and mice.
Topics: Aged; Aged, 80 and over; Animals; Apolipoproteins E; Cell Line, Tumor; Diet; Enzyme-Linked Immunosorbent Assay; Female; Hemocyanins; Homocysteine; Humans; Immunoglobulin G; Immunohistochemistry; Indicators and Reagents; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocardium; Proteins | 2008 |
Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Disease Models, Animal; Duodenum; Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Epinephrine; gamma-Aminobutyric Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sulfathiazoles | 2008 |
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents | 2008 |
Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats.
Topics: Amino Acids; Animals; Arginine; Dietary Supplements; Glutamic Acid; Histidine; Homocysteine; Hyperhomocysteinemia; Methionine; Rats | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Rats | 2008 |
Methionine, folic acid and vitamin B12 in growing-finishing pigs: impact on growth performance and meat quality.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Body Composition; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Male; Meat; Methionine; Nutritional Requirements; Random Allocation; Swine; Vitamin B 12; Vitamin B Complex; Weight Gain | 2008 |
Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Diseases; Brain-Derived Neurotrophic Factor; Cell Culture Techniques; Cells, Cultured; Cerebral Cortex; Deoxyuracil Nucleotides; Embryo, Mammalian; Exploratory Behavior; Folic Acid Deficiency; Glutathione; Hippocampus; Homocysteine; Maze Learning; Methionine; Mice; Nerve Degeneration; Neurons; Neurotransmitter Agents; Swimming; Uracil-DNA Glycosidase | 2008 |
Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.
Topics: Adult; Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; DNA Methylation; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Haplotypes; Homocysteine; Humans; Linkage Disequilibrium; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Proteins | 2008 |
Severe methylenetetrahydrofolate reductase (MTHFR) deficiency: a case report of nonclassical homocystinuria.
Topics: Child; Developmental Disabilities; Female; Homocysteine; Homocystinuria; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Severity of Illness Index; Vitamin B 12 | 2008 |
In vitro formation of homocysteine in whole blood in the presence of anticoagulants.
Topics: Anticoagulants; Blood Chemical Analysis; Catalysis; Citric Acid; Edetic Acid; Homocysteine; Humans; In Vitro Techniques; Iron; Methionine; S-Adenosylhomocysteine | 2008 |
Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice.
Topics: Animals; Antioxidants; Aorta; Aryldialkylphosphatase; Biomarkers; Caffeic Acids; Cystathionine beta-Synthase; Disease Models, Animal; Female; Flavonoids; Gene Expression Regulation, Enzymologic; Heterozygote; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Phenols; Polyphenols; Receptors, Oxidized LDL; Wine | 2009 |
Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.
Topics: Animals; Brain; Diet, Reducing; DNA Modification Methylases; DNA-Binding Proteins; Epigenesis, Genetic; Folic Acid Deficiency; Homocysteine; Male; Methionine; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Regulatory Factor X Transcription Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Transcription Factors | 2008 |
Adequate Intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load.
Topics: Adolescent; Adult; Betaine; Choline; Genotype; Hispanic or Latino; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reference Values | 2008 |
Folate deprivation, the methionine cycle, and Alzheimer's disease.
Topics: Alzheimer Disease; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2008 |
Protective effect of Embelia ribes Burm on methionine-induced hyperhomocysteinemia and oxidative stress in rat brain.
Topics: Animals; Brain; Cholesterol; Embelia; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Triglycerides | 2008 |
H2S protects against methionine-induced oxidative stress in brain endothelial cells.
Topics: Acetophenones; Acetylcysteine; Animals; Brain; Catalase; Cell Line, Transformed; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Formazans; Glutathione; Homocysteine; Hydrogen Sulfide; Methionine; Mice; Models, Biological; NG-Nitroarginine Methyl Ester; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Time Factors | 2009 |
Methionine metabolism in an animal model of sepsis.
Topics: Animals; Cysteine; Disease Models, Animal; Glutathione; Homocysteine; Lipopolysaccharides; Male; Methionine; Oxidation-Reduction; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis | 2008 |
B-vitamins, homocysteine and gene polymorphism in adults with fasting or post-methionine loading hyperhomocysteinemia.
Topics: Adult; Cross-Sectional Studies; Fasting; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Vitamin B Complex | 2008 |
Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism.
Topics: Adolescent; Adult; Autistic Disorder; Case-Control Studies; Child; Chromatography, High Pressure Liquid; DNA Methylation; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Middle Aged; Oxidative Stress; Parents; Polymorphism, Genetic | 2008 |
Methionine supplementation accelerates oxidative stress and nuclear factor kappaB activation in livers of C57BL/6 mice.
Topics: Animals; Antioxidants; Cholesterol; Dietary Supplements; Enzymes; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Oxidoreductases; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Triglycerides | 2008 |
Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone.
Topics: Aged; Animals; Bone and Bones; Collagen; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Myocardium; Osteoporosis; Porosity; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Stress, Mechanical | 2009 |
High-casein diet suppresses guanidinoacetic acid-induced hyperhomocysteinemia and potentiates the hypohomocysteinemic effect of serine in rats.
Topics: Animals; Caseins; Cysteine; Diet; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2008 |
Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation.
Topics: Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Folic Acid; Glucose; Homocysteine; Humans; Insulin; Methionine; Methylation; S-Adenosylmethionine; Sulfur | 2009 |
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
Topics: Blotting, Western; Breast Neoplasms; Colonic Neoplasms; CpG Islands; DNA Damage; DNA Methylation; Folic Acid; Gene Expression Regulation, Neoplastic; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Risk Factors; Tumor Cells, Cultured; Uracil | 2009 |
Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline.
Topics: Animals; Body Composition; Choline; Diet; Dietary Proteins; Female; Folic Acid; Homocysteine; Methionine; Models, Biological; Rats; Tissue Distribution | 2009 |
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets.
Topics: Animals; Betaine; Choline; Choline Deficiency; Cysteine; Dietary Supplements; Growth; Homocysteine; Hyperhomocysteinemia; Lipotropic Agents; Liver; Male; Methionine; Rats; Rats, Wistar | 2008 |
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.
Topics: Animals; Gene Expression Regulation; Hepatocytes; Homeostasis; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Trans-Activators; Transcription Factors; Transcription, Genetic; Transduction, Genetic | 2009 |
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.
Topics: Animals; Cystathionine beta-Synthase; Diet; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Membrane Transport Proteins; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Knockout | 2009 |
Melatonin decreases homocysteine level in blood of rats.
Topics: Aldehydes; Animals; Antioxidants; Dose-Response Relationship, Drug; Homocysteine; Humans; Malondialdehyde; Melatonin; Methionine; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar | 2008 |
[The state of oxidant-antioxidant system in basal and latent hyperhomocysteinemia in patients with atherosclerosis of the lower extremity arteries].
Topics: Antioxidants; Atherosclerosis; Catalase; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Hyperhomocysteinemia; Leg; Male; Malondialdehyde; Methionine; Middle Aged; Oxidative Stress; Prognosis | 2008 |
Mild methionine excess does not affect thymidylate synthesis or inflammation markers expression in human aortic endothelial cells.
Topics: Aorta; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Folic Acid Deficiency; Glycation End Products, Advanced; Homocysteine; Humans; Inflammation Mediators; Matrix Metalloproteinase 9; Methionine; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thymidine Monophosphate; Vascular Cell Adhesion Molecule-1 | 2009 |
Long follow up of betaine therapy in two Japanese siblings with cystathionine beta-synthase deficiency.
Topics: Adolescent; Betaine; Cystathionine beta-Synthase; Female; Gastrointestinal Agents; Homocysteine; Homocystinuria; Humans; Methionine; Siblings | 2008 |
One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders.
Topics: Aminobutyrates; Carbon; Case-Control Studies; Child; Child Development Disorders, Pervasive; Female; Genetic Predisposition to Disease; Genotype; Glutathione; Homocysteine; Humans; Male; Metabolic Networks and Pathways; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2009 |
Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs.
Topics: Amino Acids, Sulfur; Animals; Animals, Newborn; Cell Division; Cysteine; Enteral Nutrition; Epithelial Cells; Female; Glutathione; Goblet Cells; Homocysteine; Intestinal Mucosa; Iodine Radioisotopes; Methionine; Methionine Adenosyltransferase; Methylation; Models, Biological; Nitrogen Isotopes; Organ Size; Oxidation-Reduction; Sus scrofa; Tritium; Up-Regulation | 2009 |
High casein diet decreases plasma homocysteine concentration in rats.
Topics: Amino Acids; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Caseins; Cystathionine beta-Synthase; Diet; Dose-Response Relationship, Drug; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2009 |
Hypohomocysteinemic effect of cysteine is associated with increased plasma cysteine concentration in rats fed diets low in protein and methionine levels.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Caseins; Choline; Cystathionine beta-Synthase; Cysteic Acid; Cysteine; Diet, Protein-Restricted; Dietary Supplements; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Mercaptoethylamines; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; Soybean Proteins | 2009 |
Imprinting: RNA expression for homocysteine recycling in the human oocyte.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosine; Betaine-Homocysteine S-Methyltransferase; Blastocyst; Cystathionine beta-Synthase; DNA Methylation; Ethionine; Female; Fertilization in Vitro; France; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Genomic Imprinting; Homocysteine; Humans; Methionine; Oligonucleotide Array Sequence Analysis; Oocytes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Theoretical and experimental sulfur K-edge X-ray absorption spectroscopic study of cysteine, cystine, homocysteine, penicillamine, methionine and methionine sulfoxide.
Topics: Cysteine; Cystine; Homocysteine; Hydrogen-Ion Concentration; Mercury; Methionine; Molecular Conformation; Nickel; Penicillamine; Protons; Spectrometry, X-Ray Emission; Sulfur Compounds; Water | 2009 |
Homocysteine editing and growth inhibition in Escherichia coli.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Energy Metabolism; Escherichia coli; Homocysteine; Isoleucine; Leucine; Methionine; Protein Biosynthesis; Sodium Acetate | 2009 |
High dietary taurine reduces apoptosis and atherosclerosis in the left main coronary artery: association with reduced CCAAT/enhancer binding protein homologous protein and total plasma homocysteine but not lipidemia.
Topics: Analysis of Variance; Animals; Apoptosis; CCAAT-Binding Factor; Coronary Artery Disease; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Hyperlipidemias; Male; Methionine; Nitric Oxide; Oxidative Stress; Probability; Rabbits; Random Allocation; Reference Values; Sensitivity and Specificity; Taurine | 2009 |
Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats.
Topics: Animals; Cardiovascular Agents; Cysteine; Dose-Response Relationship, Drug; Glutathione; Homocysteine; Hyperhomocysteinemia; Lactates; Male; Methionine; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2009 |
Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Caseins; Cystathionine beta-Synthase; Cysteine; Dietary Proteins; Dietary Supplements; Dose-Response Relationship, Drug; Energy Intake; Glycine; Homocysteine; Liver; Male; Methionine; Organ Size; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Serine; Weight Gain | 2009 |
Identification and characterization of a strain-dependent cystathionine beta/gamma-lyase in Lactobacillus casei potentially involved in cysteine biosynthesis.
Topics: Cloning, Molecular; Cystathionine gamma-Lyase; Cysteine; DNA, Bacterial; Escherichia coli; Gene Expression; Homocysteine; Lacticaseibacillus casei; Lyases; Methionine; Molecular Sequence Data; Sequence Analysis, DNA; Sequence Analysis, Protein | 2009 |
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; Animals, Newborn; Arginine; Betaine-Homocysteine S-Methyltransferase; Body Weight; Creatine; Glycine; Homocysteine; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Organ Size; Swine | 2009 |
Sacroiliitis and muscle cramps in a healthy young man: some spearhead on MTHFR mutations.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Biomarkers; DNA Mutational Analysis; Gene Expression Regulation, Enzymologic; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Keratolytic Agents; Low Back Pain; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Cramp; Muscle, Skeletal; Mutation; Radiography; Sacroiliac Joint; Sulfasalazine; Tretinoin | 2010 |
Ontogeny of methionine utilization and splanchnic uptake in critically ill children.
Topics: Abdomen; Adolescent; Aging; Algorithms; Carbon Dioxide; Child; Child, Preschool; Critical Illness; Diet; Enteral Nutrition; Female; Homocysteine; Humans; Infant; Isotope Labeling; Kinetics; Male; Methionine; Oxidation-Reduction | 2009 |
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response | 2009 |
One-carbon metabolism-genome interactions in folate-associated pathologies.
Topics: Animals; Carbon; Child; Developmental Disabilities; Disease Models, Animal; Environment; Folic Acid; Gastrointestinal Neoplasms; Genetic Phenomena; Genome, Human; Homocysteine; Humans; Methionine; Mice; Neural Tube Defects; Purines; Risk Factors; Thymidine Monophosphate | 2009 |
Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism.
Topics: Adenosylhomocysteinase; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Docosahexaenoic Acids; Enzymes; Fish Oils; Gene Expression; Homocysteine; Lipid Metabolism; Liver; Lung; Male; Methionine; Methionine Adenosyltransferase; Olive Oil; Plant Oils; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Salmon; Tuna; Up-Regulation | 2010 |
Folic acid, vitamin B12, and homocysteine levels during fasting and after methionine load in patients with Type 1 diabetes mellitus.
Topics: Adolescent; Adult; Aging; Blood Glucose; Case-Control Studies; Child; Diabetes Mellitus, Type 1; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Sex Characteristics; Vitamin B 12; Young Adult | 2010 |
Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis.
Topics: Animals; Annexin A2; Cell Movement; Corneal Neovascularization; Diet; Endothelial Cells; Fibrin; Fibrinolysis; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Recombinant Proteins | 2009 |
DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.
Topics: Animals; Dyrk Kinases; Female; Gene Expression Regulation; Genotype; Harmine; Homocysteine; Liver; Lymphocytes; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Risk Factors | 2009 |
Effects of high methionine diet on oxidative stress in serum, apo-B containing lipoproteins, heart, and aorta in rabbits.
Topics: Animals; Aorta; Apolipoproteins B; Cholesterol; Diet; Glutathione; Homocysteine; Lipoproteins; Male; Malondialdehyde; Methionine; Myocardium; Oxidative Stress; Protein Carbonylation; Rabbits; Triglycerides | 2009 |
One-carbon metabolism and schizophrenia: current challenges and future directions.
Topics: Carbon; DNA Methylation; Environment; Epigenesis, Genetic; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Humans; Metabolic Networks and Pathways; Methionine; Mitochondrial Diseases; Receptors, Glutamate; Schizophrenia; Time Factors | 2009 |
Newborn population screening for classic homocystinuria by determination of total homocysteine from Guthrie cards.
Topics: Chromatography, High Pressure Liquid; Cystathionine beta-Synthase; DNA Mutational Analysis; Heterozygote; Homocysteine; Homocystinuria; Homozygote; Humans; Infant, Newborn; Methionine; Neonatal Screening; Qatar; Sensitivity and Specificity; Tandem Mass Spectrometry | 2010 |
Methionine metabolism in human pregnancy.
Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Homocysteine; Humans; Methionine; Methylation; Pregnancy; Statistics, Nonparametric; Young Adult | 2010 |
Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle.
Topics: Animals; Appetite Regulation; Caseins; Diet, Protein-Restricted; Dietary Fats; Dietary Supplements; DNA Methylation; Enzymes; Female; Folic Acid; Food Preferences; Glutathione; Homocysteine; Male; Methionine; Placentation; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Rats; Rats, Wistar; RNA, Messenger; Vitamin B Complex | 2010 |
The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia.
Topics: Adenosylhomocysteinase; Animals; Antioxidants; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Diet; Glycine N-Methyltransferase; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nutrigenomics; Peroxiredoxins; Proteomics; Urea | 2010 |
Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia.
Topics: Acyl Coenzyme A; Animals; Cholesterol Esters; CpG Islands; Cystathionine beta-Synthase; Diet; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Lipid Metabolism; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Oleic Acid; RNA, Messenger; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2 | 2010 |
Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aging; Autoimmune Diseases; CD27 Ligand; CD28 Antigens; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Modification Methylases; Female; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Male; Methionine; Micronutrients; Middle Aged; Receptors, KIR; T-Lymphocytes | 2010 |
Analysis of [(2)H7]methionine, [(2)H4]methionine, methionine, [(2)H4]homocysteine and homocysteine in plasma by gas chromatography-mass spectrometry to follow the fate of administered [(2)H7]methionine.
Topics: Animals; Deuterium; Esters; Gas Chromatography-Mass Spectrometry; Homocysteine; Methionine; Rats; Time Factors | 2010 |
Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways.
Topics: Adult; Creatinine; Cysteine; Erythrocytes; Female; Folic Acid; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Middle Aged; Models, Biological; Multivariate Analysis; Pancreatitis, Alcoholic; Pancreatitis, Chronic; Regression Analysis; Signal Transduction; Sulfates; Sulfur; Young Adult | 2010 |
Moderate or supranormal folic acid supplementation does not exert a protective effect for homocysteinemia and methylation markers in growing rats.
Topics: Analysis of Variance; Animals; Biomarkers; Chromatography, High Pressure Liquid; Diet; Dietary Supplements; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Glutathione; Homocysteine; Male; Methionine; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2010 |
Conversion of methionine into homocysteic acid in heavily oxidized proteomics samples.
Topics: Homocysteine; Methionine; Oxidation-Reduction; Peptides; Proteomics; Reproducibility of Results; Tandem Mass Spectrometry | 2010 |
Are plasma homocysteine and methionine elevated when binging and purging behavior complicates anorexia nervosa? Evidence against the transdiagnostic theory of eating disorders.
Topics: Adult; Anorexia Nervosa; Binge-Eating Disorder; Biomarkers; Canada; Evidence-Based Medicine; Female; Homocysteine; Humans; Laxatives; Male; Methionine; Middle Aged; Vomiting | 2009 |
Fasting and post-methionine homocysteine levels in Alzheimers disease and vascular dementia.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cohort Studies; Dementia, Vascular; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Statistics, Nonparametric; Vitamin B 12 | 2009 |
Folate bioavailability: implications for establishing dietary recommendations and optimizing status.
Topics: Adolescent; Adult; Biological Availability; Dietary Supplements; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Intestinal Absorption; Methionine; Middle Aged; Nutrition Policy; Nutritional Requirements; Premenopause; Young Adult | 2010 |
Are dietary choline and betaine intakes determinants of total homocysteine concentration?
Topics: Betaine; Cardiovascular Diseases; Choline; Cognition Disorders; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Vitamin B 12; Vitamin B 6 | 2010 |
Transcriptome profiling of a toxic dinoflagellate reveals a gene-rich protist and a potential impact on gene expression due to bacterial presence.
Topics: Amino Acid Sequence; Dinoflagellida; Evolution, Molecular; Expressed Sequence Tags; Gene Duplication; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genome, Bacterial; Homocysteine; Methionine; Molecular Sequence Data; Photosynthesis; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2010 |
Study of molecular targets influencing homocysteine and cholesterol metabolism in growing rats by manipulation of dietary selenium and methionine concentrations.
Topics: Acyl Coenzyme A; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Transporters; Blood Proteins; Cholesterol; Diet; Glutathione; Homocysteine; Lipoproteins; Liver; Male; Methionine; Rats; Receptors, LDL; Selenium; Sterol Regulatory Element Binding Protein 2 | 2010 |
Ameliorative role of rosiglitazone in hyperhomocysteinemia-induced experimental cardiac hypertrophy.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Homocysteine; Hyperhomocysteinemia; Hypertrophy, Left Ventricular; Male; Methionine; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Rosiglitazone; Thiazolidinediones | 2010 |
Should transcobalamin deficiency be treated aggressively?
Topics: Anemia, Megaloblastic; Biological Transport; DNA Mutational Analysis; DNA Primers; Female; Homocysteine; Humans; Infant; Infant, Newborn; Methionine; Methylmalonic Acid; Mutation; Polymerase Chain Reaction; Protein Structure, Tertiary; Transcobalamins | 2010 |
L-Dopa therapy increases homocysteine concentration in cerebrospinal fluid from patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Case-Control Studies; Female; Homocysteine; Humans; Levodopa; Male; Methionine; Middle Aged; Parkinson Disease; Statistics, Nonparametric | 2010 |
Two-tier approach to the newborn screening of methylenetetrahydrofolate reductase deficiency and other remethylation disorders with tandem mass spectrometry.
Topics: Algorithms; Homocysteine; Humans; Infant, Newborn; Metabolism, Inborn Errors; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neonatal Screening; Phenylalanine; Reference Values; Reproducibility of Results; Retrospective Studies; Tandem Mass Spectrometry | 2010 |
Response of European sea bass (Dicentrarchus labrax) to graded levels of methionine (total sulfur amino acids) in soya protein-based semi-purified diets.
Topics: Amino Acids, Sulfur; Animal Feed; Animals; Bass; Cysteine; Diet; Dose-Response Relationship, Drug; Energy Intake; Homocysteine; Lens, Crystalline; Methionine; Nitrogen; Nutritional Requirements; Soybean Proteins; Weight Gain | 2010 |
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.
Topics: Adolescent; Adult; Age of Onset; Aged; Brain Ischemia; Case-Control Studies; Chi-Square Distribution; Child; Female; Genetic Predisposition to Disease; Haplotypes; Homocysteine; Humans; Italy; Logistic Models; Male; Methionine; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Stroke; Young Adult | 2010 |
Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease.
Topics: Adult; Aged; Alcoholism; Aminobutyrates; Biomarkers; Case-Control Studies; Cystathionine; Disease Progression; Female; Homocysteine; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Male; Methionine; Middle Aged; Sulfur; Young Adult | 2010 |
The biosynthesis of the aroma volatile 2-methyltetrahydrothiophen-3-one in the bacterium Chitinophaga Fx7914.
Topics: Homocysteine; Isotope Labeling; Mass Spectrometry; Methionine; Pyruvic Acid; Sphingobacterium; Stereoisomerism; Thiophenes; Volatilization | 2010 |
Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cell Culture Techniques; Cell Line; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vasodilation | 2010 |
Frequency of afterload homocysteinemia in normal population of Southern Iran: a pilot study.
Topics: Adult; Female; Homocysteine; Humans; Hyperhomocysteinemia; Iran; Male; Methionine; Pilot Projects; Young Adult | 2010 |
Increased homocysteine in a patient diagnosed with Marfan syndrome.
Topics: Cystathionine beta-Synthase; Diagnosis, Differential; Female; Homocysteine; Homocystinuria; Humans; Marfan Syndrome; Methionine; Middle Aged; Mutation | 2010 |
Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment.
Topics: Ammonia; Carbon Dioxide; Chromatography, High Pressure Liquid; Cysteamine; Cysteine; Electricity; History, 20th Century; Homocysteine; Hydrogen Sulfide; Methane; Methionine; Sulfur Compounds; Ultraviolet Rays | 2011 |
Some more comments on 'folate deficiency in chronic pancreatitis'.
Topics: Folic Acid Deficiency; Glycine N-Methyltransferase; Homocysteine; Humans; Metabolic Networks and Pathways; Methionine; Pancreatitis, Chronic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Aqueous normal phase chromatography improves quantification and qualification of homocysteine, cysteine and methionine by liquid chromatography-tandem mass spectrometry.
Topics: Cardiovascular Diseases; Chromatography, Liquid; Cysteine; Homocysteine; Humans; Hydrophobic and Hydrophilic Interactions; Immunoassay; Linear Models; Methionine; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Endothelial microparticle formation in moderate concentrations of homocysteine and methionine in vitro.
Topics: Apoptosis; Cell-Derived Microparticles; Endothelial Cells; Endothelium, Vascular; Flow Cytometry; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Umbilical Cord | 2011 |
Global regulation of the response to sulfur availability in the cheese-related bacterium Brevibacterium aurantiacum.
Topics: Brevibacterium; Carbon-Oxygen Lyases; Carbon-Sulfur Lyases; Cysteine; Cystine; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Homocysteine; Metabolome; Methionine; Reverse Transcriptase Polymerase Chain Reaction; Sulfur | 2011 |
Phytoestrogen α-zearalanol improves vascular function in ovariectomized hyperhomocysteinemic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelin-1; Estradiol; Female; Homocysteine; Hyperhomocysteinemia; Methionine; Nitric Oxide Synthase Type III; Nitroprusside; Ovariectomy; Phenylephrine; Phytoestrogens; Rats; Rats, Wistar; Zeranol | 2011 |
Biodiversity in sulfur metabolism in hemiascomycetous yeasts.
Topics: Amino Acids, Sulfur; Biodiversity; Cysteine; Genetic Variation; Glucosephosphate Dehydrogenase; Glutathione; Heme; Homocysteine; Methionine; NADP; Phylogeny; Sequence Alignment; Sequence Analysis, Protein; Sulfur; Yeasts | 2011 |
Purification and characterization of a new L-methioninase from solid cultures of Aspergillus flavipes.
Topics: Animals; Aspergillus; Carbon-Sulfur Lyases; Cell Aggregation; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Inhibitors; Enzyme Stability; Hemolysis; Homocysteine; Humans; Hydrogen-Ion Concentration; Isoelectric Point; Kinetics; Liver Function Tests; Methionine; Mice; Molecular Weight; Spectrum Analysis; Substrate Specificity; Temperature | 2011 |
A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Topics: Adult; Aged; Alcohol Drinking; Body Mass Index; Case-Control Studies; Cotinine; Diabetes Complications; DNA-Binding Proteins; Europe; Female; Flavin Mononucleotide; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Logistic Models; Male; Methionine; Middle Aged; Odds Ratio; Pancreatic Neoplasms; Prospective Studies; Pyridoxal Phosphate; Riboflavin; Risk Factors; Sex Factors; Smoking; Transcription Factors; Vitamin B 12; Vitamin B Complex | 2011 |
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation.
Topics: Carcinoma, Hepatocellular; Cysteine; Cytidine; DNA Methylation; DNA Modification Methylases; Gene Expression; Glycine N-Methyltransferase; Hep G2 Cells; Hepatocytes; Homeostasis; Homocysteine; Humans; Kinetics; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Methylation; Osmolar Concentration; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3.
Topics: Animals; Cell Cycle Proteins; Disease Progression; Glycogen; Homocysteine; Humans; Hyperhomocysteinemia; Indoles; Insulin Resistance; Liver Glycogen; Methionine; Mice; Phosphorylation; PPAR gamma; Protein Serine-Threonine Kinases; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering | 2011 |
Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine.
Topics: Adipokines; Adult; Aged; Calorimetry, Indirect; Case-Control Studies; Cysteine; Fatty Liver; Female; Glutathione; Homocysteine; Humans; Inflammation Mediators; Insulin Resistance; Liver; Male; Methionine; Methylation; Middle Aged; Non-alcoholic Fatty Liver Disease; Phenylalanine; Proteins; Urea; Young Adult | 2011 |
Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins.
Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methionine; Middle Aged; Vasodilation; Vitamin E | 2011 |
Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain.
Topics: Animals; Brain; Female; Folic Acid; Frontal Lobe; Homocysteine; Homocystine; Hyperhomocysteinemia; Methionine; Methylation; Neurofilament Proteins; Phosphoproteins; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; tau Proteins | 2011 |
Hyperhomocysteinemia inhibited cardiac stem cell homing into the peri-infarcted area post myocardial infarction in rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Movement; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Male; Methionine; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stem Cell Factor; Stem Cells | 2011 |
B-vitamin deficiency is protective against DSS-induced colitis in mice.
Topics: Analysis of Variance; Animals; Body Weight; Colitis; Dextran Sulfate; Gene Expression; Glutathione; Homocysteine; Inflammation; Interleukin-10; Kaplan-Meier Estimate; Male; Metabolomics; Methionine; Methylmalonic Acid; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Peroxidase; Pyridoxal Phosphate; S-Adenosylhomocysteine; Severity of Illness Index; Tumor Necrosis Factor-alpha; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2011 |
Effects of gamma-ray-induced free radicals on the metal content and amino acid composition of human metallothionein-1.
Topics: Butyrates; Cystathionine; Cysteine; Gamma Rays; Homocysteine; Humans; Metallothionein; Methionine; Serine; Zinc | 2011 |
Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis.
Topics: Adult; Age of Onset; Analysis of Variance; Biomarkers; Case-Control Studies; Chi-Square Distribution; Cystathionine beta-Synthase; Dinoprost; Female; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Italy; Linear Models; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidative Stress; Phenotype; Platelet Activation; Platelet Function Tests; Thrombosis; Thromboxane B2; Time Factors | 2011 |
Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro.
Topics: Animals; Homocysteine; Hydrogen Peroxide; Male; Methionine; Mice; Mitochondria; Mitochondria, Liver; Rats; Rats, Wistar; Reactive Oxygen Species | 2011 |
Dietary methyl-consuming compounds and metabolic syndrome.
Topics: Animals; Arsenicals; Catecholamines; Diet; Folic Acid; Homocysteine; Humans; Hypolipidemic Agents; Insulin Resistance; Metabolic Syndrome; Methionine; Niacin; Reactive Oxygen Species | 2011 |
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Cysteine; Diet; Enzyme Inhibitors; Fatty Liver; Glutathione; Homeostasis; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 2011 |
Homocysteine homeostasis in the rat is maintained by compensatory changes in cystathionine β-synthase, betaine-homocysteine methyltransferase, and phosphatidylethanolamine N-methyltransferase gene transcription occurring in response to maternal protein an
Topics: Animal Nutritional Physiological Phenomena; Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Diet; Diet, High-Fat; Diet, Protein-Restricted; Dietary Fats; Dietary Proteins; Dietary Supplements; Down-Regulation; Female; Folic Acid; Gene Expression; Homeostasis; Homocysteine; Liver; Male; Methionine; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Pregnancy; Prenatal Nutritional Physiological Phenomena; Rats, Wistar; Vitamin B Complex; Weaning | 2011 |
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.
Topics: Animals; Biomarkers; Brain; Folic Acid Deficiency; Formates; Homocysteine; Hyperhomocysteinemia; Liver; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methionine; Methylation; Methylmalonic Acid; Models, Biological; Random Allocation; Rats; Rats, Sprague-Dawley; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2012 |
Homocysteine metabolism in peripheral blood mononuclear cells: evidence for cystathionine beta-synthase activity in resting state.
Topics: Cystathionine beta-Synthase; Glutathione; Homocysteine; Humans; Leukocytes, Mononuclear; Methionine | 2012 |
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.
Topics: Adenosine Kinase; Adult; Amino Acid Metabolism, Inborn Errors; Brain Diseases; Child; Developmental Disabilities; Family Health; Female; Fibroblasts; Homocysteine; Humans; Liver Diseases; Male; Methionine; S-Adenosylhomocysteine; S-Adenosylmethionine | 2011 |
Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Choline; Decitabine; Diet; Disease Progression; DNA Methylation; Folic Acid; Homocysteine; Humans; Male; Methionine; Mice; Mice, Nude; Prostatic Neoplasms; Tumor Cells, Cultured; Vitamin B 6 | 2012 |
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Blood Coagulation; Cystathionine beta-Synthase; Diet; Dietary Supplements; Disease Models, Animal; Homocysteine; Homocystinuria; Interleukin-1beta; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Thrombosis; Tumor Necrosis Factor-alpha | 2012 |
Reductive elimination pathway for homocysteine to methionine conversion in cobalamin-dependent methionine synthase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Homocysteine; Methionine; Models, Molecular; Oxidation-Reduction; Quantum Theory; Vitamin B 12 | 2012 |
Effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat.
Topics: Animals; Choline; Cysteine; Diet; Female; Fetus; Folic Acid; Homocysteine; Kinetics; Litter Size; Liver; Methionine; Methylation; Pancreas; Phosphorylcholine; Placenta; Pregnancy; Rats; Triglycerides; Weight Gain | 2012 |
Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study.
Topics: Aged; Betaine; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Glycosuria; Homocysteine; Humans; Linear Models; Male; Methionine; Middle Aged; New Zealand; Predictive Value of Tests; Reproducibility of Results; Sarcosine; Time Factors | 2012 |
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.
Topics: Animals; Annexin A2; Blood Coagulation; Bone Marrow Transplantation; Disease Models, Animal; Fibrinolysin; Fibrinolysis; Homocysteine; Hyperhomocysteinemia; Leukemia, Promyelocytic, Acute; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Recombinant Proteins; Tissue Plasminogen Activator | 2012 |
Metabolic adaptation of Ralstonia solanacearum during plant infection: a methionine biosynthesis case study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bacterial Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Homocysteine; Methionine; Methyltransferases; Plant Cells; Plant Diseases; Ralstonia solanacearum; Trans-Activators; Vitamin B 12 | 2012 |
Methionine-enriched diet decreases hippocampal antioxidant defences and impairs spontaneous behaviour and long-term potentiation in rats.
Topics: Analysis of Variance; Animals; Biophysics; Body Weight; Diet; Drinking; Eating; Electric Stimulation; Exploratory Behavior; Hippocampus; Homocysteine; Long-Term Potentiation; Male; Maze Learning; Methionine; Motor Activity; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2012 |
Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats.
Topics: Animals; Caseins; Choline; Choline Deficiency; Diet; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2012 |
Does phase angle correlate with hyperhomocysteinemia? A study of patients with classical homocystinuria.
Topics: Adolescent; Adult; Cysteine; Female; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Life Expectancy; Male; Methionine; Prognosis; Young Adult | 2013 |
Clinical picture of S-adenosylhomocysteine hydrolase deficiency resembles phosphomannomutase 2 deficiency.
Topics: Adenosylhomocysteinase; Congenital Disorders of Glycosylation; Diagnosis, Differential; Erythrocytes; Female; Fibroblasts; Heterozygote; Homocysteine; Humans; Infant, Newborn; Methionine; Mutation; Phosphotransferases (Phosphomutases) | 2012 |
The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Cholesterol, Dietary; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Gene Expression; Homocysteine; Hyperhomocysteinemia; Hyperlipidemias; Lipids; Male; Methionine; Mice; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides | 2012 |
Associations between maternal genotypes and metabolites implicated in congenital heart defects.
Topics: Adult; Asymptomatic Diseases; Carbon-Nitrogen Ligases; Case-Control Studies; Catalase; DNA (Cytosine-5-)-Methyltransferases; DNA Modification Methylases; DNA Repair Enzymes; Female; Folic Acid; Genotype; Glutathione; Glutathione Peroxidase; Heart Defects, Congenital; Homocysteine; Humans; Life Style; Male; Methionine; Methionine Adenosyltransferase; Polymorphism, Single Nucleotide; Risk; Tumor Suppressor Proteins | 2012 |
Evaluation of plasma homocysteine level according to the C677T and A1298C polymorphism of the enzyme MTHRF in type 2 diabetic adults.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Fasting; Female; Genotype; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic | 2012 |
The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model.
Topics: Cystathionine beta-Synthase; Down Syndrome; Folic Acid; Folic Acid Deficiency; Half-Life; Homocysteine; Humans; Methionine; Methylation; Models, Theoretical; Nutrition Surveys; Nutritional Status; Oxidative Stress; S-Adenosylmethionine; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamins | 2013 |
Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chromatin; Cyclin-Dependent Kinase 2; Down-Regulation; Female; G1 Phase Cell Cycle Checkpoints; Homocysteine; Humans; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Methionine; Multiprotein Complexes; Nuclear Proteins; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; S-Adenosylmethionine; TOR Serine-Threonine Kinases | 2012 |
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
Topics: Animals; Biomarkers; Choline; Cysteine; Disease Models, Animal; Folic Acid Deficiency; Heterozygote; Homocysteine; Isoenzymes; Liver; Male; Methionine; Methylation; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis, Insertional; Mutant Proteins; Random Allocation | 2013 |
Excess dietary methionine does not affect fracture healing in mice.
Topics: Animals; Biomechanical Phenomena; Collagen Type I; Diet; Dietary Supplements; Femur; Fracture Healing; Homocysteine; Metabolic Networks and Pathways; Methionine; Mice; Osteocalcin; Peptides; Radiography | 2012 |
Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.
Topics: Administration, Oral; Animals; Catalase; Cycas; Diet; Dietary Supplements; Folic Acid; Glutathione Peroxidase; Heart; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tocotrienols | 2013 |
Hepatic metabolism of sulfur amino acids in db/db mice.
Topics: Amino Acids, Sulfur; Animals; Betaine-Homocysteine S-Methyltransferase; Cysteine; Cysteine Dioxygenase; Diabetes Mellitus, Experimental; Dipeptides; Glutathione; Homocysteine; Ligases; Lipid Peroxidation; Liver; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Putrescine; Receptors, Leptin; S-Adenosylmethionine; Spermidine; Taurine; Triglycerides; Up-Regulation | 2013 |
Metal-catalyzed oxidation of protein methionine residues in human parathyroid hormone (1-34): formation of homocysteine and a novel methionine-dependent hydrolysis reaction.
Topics: Catalysis; Homocysteine; Humans; Hydrolysis; Mass Spectrometry; Methionine; Oxidation-Reduction; Parathyroid Hormone; Pentetic Acid | 2013 |
Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
Topics: Betaine; Child Development; Child, Preschool; Choline; Cognition; Female; Homocysteine; Humans; Language; Linear Models; Longitudinal Studies; Male; Methionine; Neuropsychological Tests; Nutritional Status; Pregnancy; Sarcosine; Seychelles | 2013 |
Involvement of 5-methyltetrahydrofolate in the amelioration of hyperhomocysteinemia caused by vitamin B(6) deficiency and L-methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Dietary Supplements; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Tetrahydrofolates; Vitamin B 6; Vitamin B 6 Deficiency | 2013 |
Quercetin reduces serum homocysteine level in rats fed a methionine-enriched diet.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Glutathione; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Organ Size; Oxidative Stress; Protein Carbonylation; Quercetin; Random Allocation; Rats; Rats, Wistar; Weight Gain | 2013 |
LC-MS/MS identification of the one-carbon cycle metabolites in human plasma.
Topics: Adult; Chromatography, Liquid; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Multiple Sclerosis; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2013 |
[Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder].
Topics: Bipolar Disorder; Case-Control Studies; Cognition; Folic Acid; Homocysteine; Humans; Methionine; Psychiatric Status Rating Scales; Severity of Illness Index; Vitamin B 12 | 2013 |
Characterization of homocysteine γ-lyase from submerged and solid cultures of Aspergillus fumigatus ASH (JX006238).
Topics: Aspergillus fumigatus; Biosensing Techniques; Culture Media; Cysteine; DNA, Fungal; DNA, Ribosomal; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Enzyme Stability; Homocysteine; Hydrogen-Ion Concentration; Isoelectric Point; Kinetics; Lyases; Methionine; Molecular Sequence Data; Molecular Weight; Sequence Analysis, DNA; Substrate Specificity; Temperature | 2013 |
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
Topics: Adolescent; Adult; Betaine; Biomarkers; Choline; Cysteine; Diet; Diet Records; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; DNA Methylation; Feeding Behavior; Female; Folic Acid; Gambia; Homocysteine; Humans; Linear Models; Methionine; Middle Aged; Nutrition Assessment; Prospective Studies; Riboflavin; Rural Population; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Vitamin B 12; Vitamin B 6; Young Adult | 2013 |
Expressed protein ligation at methionine: N-terminal attachment of homocysteine, ligation, and masking.
Topics: Homocysteine; Methionine; Proteins | 2013 |
Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophage-specific reverse cholesterol transport.
Topics: Animals; Antioxidants; Apolipoprotein A-I; Aryldialkylphosphatase; Atherosclerosis; Biological Transport; Cell Line; Cholesterol, HDL; Disease Models, Animal; Female; Homocysteine; Hyperhomocysteinemia; Lipid Metabolism; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2013 |
Effect of polyunsaturated fatty acids on homocysteine metabolism through regulating the gene expressions involved in methionine metabolism.
Topics: Administration, Oral; Animals; Fatty Acids, Unsaturated; Gene Expression Regulation; Homocysteine; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley | 2013 |
Early biochemical and hematological response to intramuscular cyanocobalamin therapy in vitamin B(12)-deficient patients.
Topics: Aged; Chromatography, High Pressure Liquid; Cysteine; Erythrocyte Indices; Female; Folic Acid; Homocysteine; Humans; Injections, Intramuscular; Male; Methionine; Methylmalonic Acid; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
A population model of folate-mediated one-carbon metabolism.
Topics: Carbon; Diet; Folic Acid; Homocysteine; Humans; Liver; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Models, Theoretical; Nutrition Surveys; Oxidative Stress; Polymorphism, Genetic | 2013 |
Stroke in a young man.
Topics: Adult; Betaine; Cystathionine beta-Synthase; Diet, Protein-Restricted; Homocysteine; Homocystinuria; Humans; Lipotropic Agents; Male; Methionine; Platelet Aggregation Inhibitors; Pyridoxine; Stroke; Treatment Outcome; Vision Disorders; Vitamin B Complex | 2013 |
Neurologically normal development of a patient with severe methionine adenosyltransferase I/III deficiency after continuing dietary methionine restriction.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Glycine N-Methyltransferase; Heterozygote; Homocysteine; Humans; Male; Methionine; Methionine Adenosyltransferase; Mutation; Nervous System Diseases | 2013 |
Levels of key enzymes of methionine-homocysteine metabolism in preeclampsia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Female; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity.
Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Homocysteine; Humans; Liver Function Tests; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine | 2014 |
Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two Caucasian populations.
Topics: Adipose Tissue; Aged; Aged, 80 and over; Amino Acids, Sulfur; Cohort Studies; Cross-Sectional Studies; Cystathionine; Cysteine; Diet; Dipeptides; Exercise; Fatty Acids; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Stearoyl-CoA Desaturase; Surveys and Questionnaires; White People | 2013 |
Dietary practices in pyridoxine non-responsive homocystinuria: a European survey.
Topics: Adolescent; Adult; Betaine; Child; Child, Preschool; Diet, Protein-Restricted; Europe; Female; Homocysteine; Homocystinuria; Humans; Infant; Male; Methionine; Pyridoxine; Surveys and Questionnaires; Treatment Outcome | 2013 |
Adult-onset eculizumab-resistant hemolytic uremic syndrome associated with cobalamin C deficiency.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Antibodies, Monoclonal, Humanized; Betaine; Biopsy; Carrier Proteins; Diagnosis, Differential; Drug Resistance; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Hypertension, Malignant; Immunologic Factors; Kidney; Kidney Function Tests; Leucovorin; Lipotropic Agents; Male; Methionine; Methylmalonic Acid; Mutation; Oxidoreductases; Recurrence; Renal Dialysis; Treatment Outcome; Vitamin B 12 Deficiency; Vitamin B Complex | 2014 |
Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Analysis of Variance; Chromatography, Liquid; Deoxycytosine Nucleotides; DNA Methylation; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; ROC Curve; Tritium | 2014 |
Development of an animal model for gestational hypermethioninemia in rat and its effect on brain Na⁺,K⁺-ATPase/Mg²⁺-ATPase activity and oxidative status of the offspring.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Brain; Brain Chemistry; Ca(2+) Mg(2+)-ATPase; Catalase; Disease Models, Animal; Female; Glycine N-Methyltransferase; Homocysteine; Maternal-Fetal Exchange; Methionine; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Pregnancy; Pregnancy Complications; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2014 |
Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis.
Topics: Catalysis; Crystallography, X-Ray; Disulfides; Echinomycin; Homocysteine; Hydrogen Bonding; Methionine; Methyltransferases; Protein Structure, Tertiary; Quinoxalines | 2014 |
The control of hyperhomocysteinemia through thiol exchange mechanisms by mesna.
Topics: Adult; Antioxidants; Drug Evaluation, Preclinical; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mesna; Methionine; Middle Aged; Oxidation-Reduction | 2014 |
Characterization of N-homocysteinylated albumin adducts.
Topics: Homocysteine; Humans; Lysine; Methionine; Serum Albumin | 2014 |
Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Case-Control Studies; Cystathionine beta-Synthase; Female; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multiple Sclerosis; Polymorphism, Genetic; S-Adenosylmethionine | 2014 |
Structural analysis of a fungal methionine synthase with substrates and inhibitors.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Candida albicans; Catalytic Domain; Crystallography, X-Ray; Folic Acid; Fungal Proteins; Homocysteine; Kinetics; Methionine; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Zinc | 2014 |
Taurine supplementation does not decrease homocysteine levels and liver injury induced by a choline-deficient diet.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Choline Deficiency; Cysteine; Diet; Dietary Supplements; Gene Expression Regulation; Homocysteine; Liver; Malondialdehyde; Methionine; Rats; Taurine | 2014 |
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase; Disease Models, Animal; DNA Methylation; Ferredoxin-NADP Reductase; Gene Expression; Hippocampus; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Male; Memory, Short-Term; Methionine; Mice; Mice, Knockout; Synaptic Transmission | 2014 |
Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice.
Topics: Animals; Dietary Supplements; Female; Glutathione; Homocysteine; Lipid Metabolism; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Triglycerides | 2014 |
Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration.
Topics: Animals; Aryldialkylphosphatase; Brain; Diet; Electrophoresis, Polyacrylamide Gel; Homocysteine; Methionine; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Quantitation of sulfur-containing amino acids, homocysteine, methionine and cysteine in dried blood spot from newborn baby by HPLC-fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Cysteine; Dried Blood Spot Testing; Female; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Male; Methionine; Neonatal Screening | 2014 |
Cheese 'refinement' with whey B-vitamin removal during precipitation potentially induces temporal 'functional' dietary shortage: homocysteine as a biomarker.
Topics: Adult; Biomarkers; Body Mass Index; Cheese; Diet; Dietary Supplements; Endpoint Determination; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Israel; Methionine; Middle Aged; Vitamin B 6; Vitamin B Complex | 2014 |
Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells.
Topics: Animals; Atherosclerosis; C-Reactive Protein; Cells, Cultured; Dizocilpine Maleate; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; Interleukins; Male; MAP Kinase Signaling System; Methionine; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; NF-kappa B; Onium Compounds; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Superoxides; Thenoyltrifluoroacetone | 2014 |
Hyperhomocysteinemia induced by methionine dietary nutritional overload modulates acetylcholinesterase activity in the rat brain.
Topics: Acetylcholinesterase; Animals; Brain; Diet; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats, Wistar | 2014 |
Central and systemic responses to methionine-induced hyperhomocysteinemia in mice.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cysteine; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Motor Activity; Recognition, Psychology; Time Factors | 2014 |
Homocysteine reduces protein S-nitrosylation in endothelium.
Topics: Animals; Aorta; Endothelium, Vascular; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein S; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Transcription Factor RelA; Vascular Cell Adhesion Molecule-1 | 2014 |
Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.
Topics: Animals; Cerebral Arteries; Diet; Disease Models, Animal; Endothelium, Vascular; Female; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Phenotype; Reactive Oxygen Species; Thrombosis; Vasodilator Agents | 2014 |
Involvement of the yciW gene in l-cysteine and l-methionine metabolism in Escherichia coli.
Topics: Bridged Bicyclo Compounds; Cysteine; Escherichia coli; Homocysteine; Methionine; Regulon; Sulfur; Tandem Mass Spectrometry | 2015 |
Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress.
Topics: Animals; Behavior, Animal; Betaine-Homocysteine S-Methyltransferase; Chronic Disease; Depression; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats, Wistar; Recombinant Proteins; Sertraline; Stress, Psychological | 2014 |
Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.
Topics: Animals; Apoptosis; Betaine-Homocysteine S-Methyltransferase; Catalase; Chromatography, High Pressure Liquid; Cochlea; Female; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Glutathione Synthase; Hair Cells, Auditory; Hearing Loss; Homocysteine; Hyperhomocysteinemia; In Situ Nick-End Labeling; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Stress; Phospholipid Hydroperoxide Glutathione Peroxidase | 2015 |
Role of homocysteinylation of ACE in endothelial dysfunction of arteries.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Coronary Vessels; Endothelium, Vascular; Homocysteine; Male; Mesenteric Arteries; Methionine; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Superoxides; Vasodilation | 2015 |
Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Cardiovascular Agents; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Homocysteine; Hyperalgesia; Hypoxia-Ischemia, Brain; Male; Methionine; Movement; Muscle, Skeletal; Myalgia; Rats, Sprague-Dawley; Reflex Sympathetic Dystrophy; Touch; Vibration | 2015 |
Whey protein supplementation increases methionine intake but not homocysteine plasma concentration in rats.
Topics: Advanced Oxidation Protein Products; Animals; Biomarkers; Caseins; Dietary Supplements; Glutathione; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Methionine; Muscle, Skeletal; Oxidation-Reduction; Oxidative Stress; Random Allocation; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Whey Proteins | 2015 |
Heterozygous carriers of classical homocystinuria tend to have higher fasting serum homocysteine concentrations than non-carriers in the presence of folate deficiency.
Topics: Aged; Cardiovascular Diseases; Case-Control Studies; Cystathionine beta-Synthase; Dietary Supplements; Fasting; Female; Folic Acid; Folic Acid Deficiency; Genotyping Techniques; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Prevalence; Risk Factors; Taiwan; Vitamin B 12 | 2015 |
The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation.
Topics: Amino Acid Substitution; Catalytic Domain; Homocysteine; Methionine; Methyltransferases; Protein Binding; Substrate Specificity; Tetrahydrofolates | 2015 |
L-serine supplementation attenuates alcoholic fatty liver by enhancing homocysteine metabolism in mice and rats.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Dietary Supplements; Energy Intake; Ethanol; Fatty Liver, Alcoholic; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; S-Adenosylmethionine; Serine; Triglycerides | 2015 |
Label-free colorimetric detection of biothiols utilizing SAM and unmodified Au nanoparticles.
Topics: Biosensing Techniques; Colorimetry; Cysteine; Glutathione; Gold; Homocysteine; Humans; Limit of Detection; Metal Nanoparticles; Methionine | 2015 |
Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Hippocampus; Homocysteine; Memory; Methionine; Mice; Mice, Inbred C57BL; Models, Animal; Nutritional Requirements; Promoter Regions, Genetic; Receptors, AMPA; Receptors, Glutamate | 2015 |
Dysfunction of blood pressure regulation in hyperhomocyteinemia model in rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Elastic Tissue; Epinephrine; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidation-Reduction; Rats, Sprague-Dawley; Risk Factors; Thiobarbiturates | 2015 |
Outcomes of four patients with homocysteine remethylation disorders detected by newborn screening.
Topics: Amino Acid Metabolism, Inborn Errors; Female; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Neonatal Screening; Psychotic Disorders; Treatment Outcome | 2016 |
Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia.
Topics: Animals; Apoptosis; Binding Sites; Cells, Cultured; DNA-Binding Proteins; Endothelial Cells; Enzyme Activation; Heat Shock Transcription Factors; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins, LDL; Methionine; Mice; Mice, Inbred C57BL; NADPH Oxidases; Phosphorylation; Protein Kinase C beta; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Messenger; Scavenger Receptors, Class E; Sirtuin 1; Transcription Factors; Up-Regulation | 2015 |
[Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats].
Topics: Amino Acids; Animals; Beta vulgaris; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Choline Deficiency; Cysteine; Diet; Dietary Supplements; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Rats; Rats, Wistar | 2015 |
Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter.
Topics: Animals; Cells, Cultured; Cystathionine gamma-Lyase; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Inflammation Mediators; Macrophages; Male; Methionine; Mice; Morpholines; Organothiophosphorus Compounds; Promoter Regions, Genetic; Signal Transduction | 2015 |
Sulfur amino acid metabolism in Zucker diabetic fatty rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosylhomocysteinase; Animals; Area Under Curve; Betaine; Betaine-Homocysteine S-Methyltransferase; Cysteine; Dipeptides; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; Homocysteine; Liver; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Rats; Rats, Zucker; S-Adenosylhomocysteine; S-Adenosylmethionine; Spermidine; Spermine; Taurine | 2015 |
A Protein Extract from Chicken Reduces Plasma Homocysteine in Rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Caseins; Chickens; Choline; Cystathionine gamma-Lyase; Cysteine; Dietary Proteins; Folic Acid; Glycine; Homocysteine; Liver; Male; Meat; Methionine; Rats; Rats, Wistar; Riboflavin; RNA, Messenger; Sarcosine; Serine; Vitamin B 12; Vitamin B 6 | 2015 |
Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder.
Topics: Adolescent; Autism Spectrum Disorder; Biomarkers; Child; Child, Preschool; Communication Disorders; Diagnostic and Statistical Manual of Mental Disorders; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Tyrosine | 2015 |
[Effects of dietary wheat gluten level on decreasing plasma homocysteine concentration in rats].
Topics: Amino Acids; Animals; Caseins; Cysteine; Diet; Dietary Proteins; Glutens; Homocysteine; Liver; Methionine; Proteins; Rats; Rats, Wistar; Threonine; Triticum | 2015 |
Two-dimensional high performance liquid chromatography for determination of homocysteine, methionine and cysteine enantiomers in human serum.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Cysteine; Female; Homocysteine; Humans; Limit of Detection; Male; Methionine; Multiple Sclerosis; Signal-To-Noise Ratio; Stereoisomerism; Young Adult | 2015 |
Accurate measurement of the essential micronutrients methionine, homocysteine, vitamins B6, B12, B9 and their metabolites in plasma, brain and maternal milk of mice using LC/MS ion trap analysis.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Male; Mass Spectrometry; Methionine; Mice; Mice, Inbred C57BL; Micronutrients; Milk; Vitamin B 12; Vitamin B 6 | 2015 |
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary Supplements; Female; Glycine; Homocysteine; Humans; Kynurenine; Leucine; Methionine; Methylamines; Multivariate Analysis; Pyridoxal Phosphate; Pyridoxine; Serine; Tryptophan; Vitamin B 6 Deficiency; Young Adult | 2015 |
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acyl Coenzyme A; Adenosylhomocysteinase; Animals; B-Lymphocytes; Betaine-Homocysteine S-Methyltransferase; Blood Chemical Analysis; Cystathionine beta-Synthase; Cysteine; Diet, High-Fat; Dipeptides; DNA Methylation; Female; Glutathione; Glycine N-Methyltransferase; Homocysteine; Liver; Metabolic Networks and Pathways; Metabolome; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Random Allocation | 2015 |
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats.
Topics: Animal Feed; Animals; Carnitine; Diet; Dietary Proteins; Euphausiacea; Homocysteine; Male; Methionine; Methylamines; Phospholipids; Rats; Rats, Wistar | 2015 |
Effect of multi-nutrient insufficiency on markers of one carbon metabolism in young women: response to a methionine load.
Topics: Adult; Amino Acids; Biomarkers; Body Height; Carbon; Female; Folic Acid; Food; Glutathione; Homocysteine; Humans; India; Malnutrition; Methionine; Ohio; Vitamin B 12; Vitamin B Complex | 2016 |
Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver.
Topics: Animals; Cystathionine beta-Synthase; Drug Evaluation, Preclinical; Enzyme Induction; Homocysteine; Lipid Peroxidation; Liver; Male; Methionine; Palm Oil; Plant Extracts; Plant Oils; Rats, Wistar; Tocotrienols | 2015 |
Betaine is as effective as folate at re-synthesizing methionine for protein synthesis during moderate methionine deficiency in piglets.
Topics: Animals; Betaine; Carbon Isotopes; Choline; Cysteine; Diet; Dietary Supplements; Folic Acid; Homocysteine; Methionine; Models, Biological; Oxidation-Reduction; Phenylalanine; Protein Biosynthesis; Swine | 2016 |
NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Betaine; Blotting, Western; Cells, Cultured; Cysteine; Female; Glutathione; Hep G2 Cells; Homocysteine; Humans; Immunoenzyme Techniques; Liver; Liver Diseases; Methionine; Mice; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; Reactive Oxygen Species; S-Adenosylmethionine | 2015 |
Quercetin Increases Hepatic Homocysteine Remethylation and Transsulfuration in Rats Fed a Methionine-Enriched Diet.
Topics: Animals; Case-Control Studies; Gene Expression; Homocysteine; Male; Metabolic Networks and Pathways; Methionine; Methylation; Quercetin; Rats; Rats, Wistar | 2015 |
Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Homocysteine; Homocysteine S-Methyltransferase; Methionine; Models, Molecular; Molecular Sequence Data; Sequence Alignment | 2016 |
Sulfur amino acids and atherosclerosis: a role for excess dietary methionine.
Topics: Amino Acids, Sulfur; Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Blood Chemical Analysis; Diet; Disease Models, Animal; Homocysteine; Metabolic Networks and Pathways; Methionine; Mice; Mice, Knockout; Plaque, Atherosclerotic; Time Factors | 2016 |
Low bone mineral density is a common finding in patients with homocystinuria.
Topics: Absorptiometry, Photon; Adolescent; Adult; Bone Density; Child; Child, Preschool; Female; Homocysteine; Homocystinuria; Humans; Lumbar Vertebrae; Male; Methionine; Middle Aged; Osteoporosis; Retrospective Studies; Young Adult | 2016 |
Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Cell Line, Tumor; Colorectal Neoplasms; DNA Methylation; Homocysteine; Humans; Methionine; Neoplasms; RNA; S-Adenosylmethionine; Serine; Stress, Physiological | 2016 |
Simultaneous detection of five one-carbon metabolites in plasma using stable isotope dilution liquid chromatography tandem mass spectrometry.
Topics: Female; Homocysteine; Humans; Isotope Labeling; Limit of Detection; Linear Models; Methionine; Pregnancy; Reproducibility of Results; Tandem Mass Spectrometry; Vitamin B 12 Deficiency | 2016 |
Selenium Inhibits Homocysteine-Induced Endothelial Dysfunction and Apoptosis via Activation of AKT.
Topics: Animals; Apoptosis; Cell Movement; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Male; Methionine; Proto-Oncogene Proteins c-akt; Rats; Selenium | 2016 |
Atorvastatin attenuates atherosclerotic plaque destabilization by inhibiting endoplasmic reticulum stress in hyperhomocysteinemic mice.
Topics: Animals; Aorta; Apolipoproteins E; Atorvastatin; Blotting, Western; Down-Regulation; Endoplasmic Reticulum Stress; Homocysteine; Hyperhomocysteinemia; Macrophages; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Knockout; Plaque, Atherosclerotic; RAW 264.7 Cells; Real-Time Polymerase Chain Reaction; Thapsigargin; Tumor Necrosis Factor-alpha | 2016 |
Chemoselective synthesis of functional homocysteine residues in polypeptides and peptides.
Topics: Alkylation; Biomimetic Materials; Homocysteine; Hydrogen-Ion Concentration; Methionine; Methylation; Peptides; Sulfonium Compounds | 2016 |
Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats.
Topics: Adenosylhomocysteinase; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carotenoids; Cystathionine beta-Synthase; Diet; Homocysteine; Hyperhomocysteinemia; Liver; Liver Diseases; Lycopene; Male; Malondialdehyde; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2016 |
Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet.
Topics: Animals; Animals, Newborn; Betaine; Choline Deficiency; Creatine; Diet; Female; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Phosphatidylcholines; Protein Biosynthesis; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Tritium | 2016 |
The effect of increasing concentrations of dl-methionine and 2-hydroxy-4-(methylthio) butanoic acid on hepatic genes controlling methionine regeneration and gluconeogenesis.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosylhomocysteinase; Animals; Animals, Newborn; Betaine; Betaine-Homocysteine S-Methyltransferase; Carnitine O-Palmitoyltransferase; Cattle; Down-Regulation; Gluconeogenesis; Glucose-6-Phosphatase; Hepatocytes; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methylenetetrahydrofolate Reductase (NADPH2); Phosphoenolpyruvate Carboxykinase (GTP); S-Adenosylmethionine; Up-Regulation | 2016 |
High-throughput method for the quantitation of metabolites and co-factors from homocysteine-methionine cycle for nutritional status assessment.
Topics: Adolescent; Child; Chromatography, High Pressure Liquid; Cohort Studies; Erythrocytes; Female; High-Throughput Screening Assays; Homocysteine; Humans; Limit of Detection; Male; Metabolic Networks and Pathways; Methionine; Nutritional Status; Reproducibility of Results; Tandem Mass Spectrometry | 2016 |
Methionine Metabolites in Patients With Sepsis.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Catheter-Related Infections; Cohort Studies; Female; Homocysteine; Hospital Mortality; Humans; Intraabdominal Infections; Logistic Models; Male; Methionine; Middle Aged; Prognosis; Prospective Studies; Respiratory Tract Infections; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis; Skin Diseases, Infectious; Urinary Tract Infections | 2018 |
Lipid profile status and other related factors in patients with Hyperphenylalaninaemia.
Topics: Apolipoproteins A; Apolipoproteins B; Blood Pressure; C-Reactive Protein; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Cross-Sectional Studies; Female; Homocysteine; Humans; Lipids; Male; Methionine; Phenylketonurias; Risk Factors; Triglycerides; Vitamin B 12 | 2016 |
Prospective associations of maternal betaine status with offspring weight and body composition at birth: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study.
Topics: Adipose Tissue; Adolescent; Adult; Betaine; Birth Weight; Body Composition; Body Mass Index; Choline; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Infant; Linear Models; Male; Methionine; Middle Aged; Nutritional Status; Prospective Studies; Sensitivity and Specificity; Singapore; Vitamin B 12; Young Adult | 2016 |
Intriguing cellular processing of a fluorinated amino acid during protein biosynthesis in Escherichia coli.
Topics: Amino Acids; Bacteriophage lambda; Escherichia coli; Escherichia coli Proteins; Ethionine; Halogenation; Homocysteine; Methionine; Methionine-tRNA Ligase; Models, Molecular; Muramidase; Protein Biosynthesis; Viral Proteins | 2016 |
High-throughput and simultaneous quantitative analysis of homocysteine-methionine cycle metabolites and co-factors in blood plasma and cerebrospinal fluid by isotope dilution LC-MS/MS.
Topics: Chromatography, High Pressure Liquid; High-Throughput Screening Assays; Homocysteine; Humans; Indicator Dilution Techniques; Limit of Detection; Metabolic Networks and Pathways; Metabolomics; Methionine; Middle Aged; Tandem Mass Spectrometry | 2017 |
Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs.
Topics: Anti-Bacterial Agents; Bacteria; Drug Resistance, Microbial; Folic Acid; Homocysteine; Methionine; Microbial Sensitivity Tests; Vitamin B 12 | 2016 |
Simultaneous Determination of Methionine and Homocysteine by on-column derivatization with o-phtaldialdehyde.
Topics: Adult; Animals; Chromatography, High Pressure Liquid; Female; Homocysteine; Homocystinuria; Humans; Limit of Detection; Male; Methionine; Mice; Mice, Transgenic; o-Phthalaldehyde | 2016 |
Simultaneous determination of plasma total homocysteine and methionine by liquid chromatography-tandem mass spectrometry.
Topics: Blood Chemical Analysis; Chromatography, Liquid; Homocysteine; Humans; Limit of Detection; Linear Models; Methionine; Reproducibility of Results; Tandem Mass Spectrometry; Time Factors | 2017 |
Characteristic peripheral blood smear findings in disorders of cobalamin metabolism.
Topics: Erythrocytes, Abnormal; Ferredoxin-NADP Reductase; Homocysteine; Humans; Infant; Male; Methionine; Mutation; Neutrophils; Vitamin B 12; Vitamin B 12 Deficiency | 2016 |
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia.
Topics: Acetylcholinesterase; Animals; Aorta; Brain; Catalase; Cholesterol; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Endothelium, Vascular; Flavonoids; Flavonols; Glutathione; Homocysteine; Hyperhomocysteinemia; Indans; Lipid Peroxidation; Male; Maze Learning; Methionine; Necrosis; Nitric Oxide; Nitrites; Piperidines; Rats; Superoxide Dismutase | 2017 |
Conformational status of cytochrome c upon N-homocysteinylation: Implications to cytochrome c release.
Topics: Animals; Apoptosis; Cardiolipins; Cattle; Circular Dichroism; Cytochromes c; Electron Spin Resonance Spectroscopy; Heme; Homocysteine; Iron; Ligands; Methionine; Myocardium; Oxygen; Peroxidase; Peroxidases; Protein Conformation; Protein Processing, Post-Translational; Spectrophotometry, Ultraviolet | 2017 |
Efficacy of early treatment in patients with cobalamin C disease identified by newborn screening: a 16-year experience.
Topics: Cohort Studies; Dietary Proteins; Female; Homocysteine; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Methionine; Methylmalonic Acid; Neonatal Screening; Neurocognitive Disorders; Retrospective Studies; Secondary Prevention; Vitamin B 12 Deficiency | 2017 |
Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cells, Cultured; Endoplasmic Reticulum Stress; Gene Expression Regulation; Hepatocytes; Homocysteine; Hyperhomocysteinemia; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organ Size; Phenylbutyrates; Random Allocation; Tunicamycin | 2017 |
Effect of arginine:lysine and glycine:methionine intake ratios on dyslipidemia and selected biomarkers implicated in cardiovascular disease: A study with hypercholesterolemic rats.
Topics: Administration, Oral; Amino Acids; Animals; Arginine; Biomarkers; Body Weight; Cardiovascular Diseases; Dyslipidemias; Glycine; Homocysteine; Hypercholesterolemia; Lipids; Liver; Lysine; Male; Methionine; Nitric Oxide; Organ Size; Rats, Wistar | 2017 |
Methionine metabolism and multiple sclerosis.
Topics: Adult; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Electrochemical Techniques; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Middle Aged; Multiple Sclerosis | 2017 |
[A new link between high homocysteine levels, cancers and neurodegenerative diseases].
Topics: Homocysteine; Humans; Hyperhomocysteinemia; Metabolic Networks and Pathways; Methionine; Neoplasms; Neurodegenerative Diseases; Risk Factors | 2017 |
Tolerance to increased supplemented dietary intakes of methionine in healthy older adults.
Topics: Aged; Aging; Dietary Supplements; Dose-Response Relationship, Drug; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Reference Values | 2017 |
Relevance of plasma levels of free homocysteine and methionine as risk predictors for ischemic stroke in the young.
Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Odds Ratio; Risk Factors; Stroke; Vitamin B 12; Vitamin B 6; Young Adult | 2018 |
Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice.
Topics: Animals; Antioxidants; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cycloleucine; Cystathionine beta-Synthase; Defoliants, Chemical; Dietary Supplements; Diquat; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glutathione; Hepatocytes; Homocysteine; Male; Methionine; Methionine Adenosyltransferase; Mice, Inbred C57BL; Oxidative Stress; Random Allocation; RNA Interference; Serine; Specific Pathogen-Free Organisms | 2017 |
Correlations Between Methionine Cycle Metabolism, COMT Genotype, and Polyneuropathy in L-Dopa Treated Parkinson's Disease: A Preliminary Cross-Sectional Study.
Topics: Aged; Catechol O-Methyltransferase; Cognition Disorders; Cross-Sectional Studies; Female; Genotype; Homocysteine; Humans; Levodopa; Male; Methionine; Middle Aged; Neuropsychological Tests; Parkinson Disease; Polymorphism, Single Nucleotide; Polyneuropathies; Statistics, Nonparametric; Vitamins | 2017 |
[Metabolic changes in pulmonary mitochondria of rats with experimental hyperhomocysteinemia].
Topics: Animals; Enzyme Inhibitors; Homocysteine; Humans; Hyperhomocysteinemia; L-Lactate Dehydrogenase; Lung; Male; Methionine; Mitochondria; Mitochondrial Proton-Translocating ATPases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Phosphorylation; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxide Dismutase | 2017 |
Methionine-supplemented diet affects the expression of cardiovascular disease-related genes and increases inflammatory cytokines in mice heart and liver.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Cytokines; Diet; Dietary Supplements; Female; Gene Expression Regulation; Heart; Homocysteine; Liver; Methionine; Mice; Myocardium; Oxidative Stress | 2017 |
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.
Topics: Amino Acid Transport System y+; Breast Neoplasms; Carcinogenesis; Cell Line; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Cysteine; Cystine; Female; Gene Expression; Glutamic Acid; Homocysteine; Humans; Mammary Glands, Human; MCF-7 Cells; Methionine; Mutation | 2017 |
Demethylation of methionine and keratin damage in human hair.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Copper; Female; Hair; Homocysteine; Humans; Infant; Iron; Keratins; Male; Methionine; Methylation; Middle Aged | 2018 |
Vitamin B complex mitigates cardiac dysfunction in high-methionine diet-induced hyperhomocysteinemia.
Topics: Animals; Catalase; Diet; Glutathione; Heart; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Vitamin B Complex | 2018 |
Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Body Weight; Brain; Caspase 3; Caspase 9; DNA Damage; Homocysteine; Hydrolyzable Tannins; Male; Methionine; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2018 |
Folinic Acid Increases Protein Arginine Methylation in Human Endothelial Cells.
Topics: Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Leucovorin; Methionine; Methylation; Protein Processing, Post-Translational; S-Adenosylhomocysteine | 2018 |
Oxidative stress and dietary micronutrient deficiencies contribute to overexpression of epigenetically regulated genes by lupus T cells.
Topics: Adult; Aged; Case-Control Studies; CD4-Positive T-Lymphocytes; Choline; Diet; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Female; Flow Cytometry; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Lupus Erythematosus, Systemic; Male; Methionine; Micronutrients; Middle Aged; Oxidative Stress; Peroxynitrous Acid; Riboflavin; T-Lymphocytes; Vitamin B 12; Vitamin B 6; Young Adult; Zinc | 2018 |
Evaluation of tracer labelled methionine load test in vitamin B-12 deficient adolescent women.
Topics: Administration, Oral; Adolescent; Body Mass Index; Carbon Dioxide; Carbon Isotopes; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Iron; Methionine; Serologic Tests; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
The effects of L-cysteine and N-acetyl-L-cysteine on homocysteine metabolism and haemostatic markers, and on cardiac and aortic histology in subchronically methionine-treated Wistar male rats.
Topics: Acetylcysteine; Animals; Aorta; Biomarkers; Cysteine; Heart; Hemostatics; Homocysteine; Male; Methionine; Rats; Rats, Wistar | 2019 |
Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.
Topics: Acetylcholine; Animals; Diet; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Male; Methionine; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Vasodilation | 2018 |
The high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) may explain naked mole-rat's distinct methionine metabolite profile compared to mouse.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Enzyme Activation; Homocysteine; Homocystinuria; Methionine; Mice; Mole Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2018 |
Methionine deficiency decreases hepatic lipid exportation and induces liver lipid accumulation in broilers.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chickens; Diet; Dietary Supplements; Gene Expression; Homocysteine; Lipid Metabolism; Liver; Male; Methionine; Random Allocation | 2018 |
Homocysteine and age-associated disorders.
Topics: Aged; Aging; Bone Diseases; Chronic Disease; Hearing Loss; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Quality of Life; Renal Insufficiency; Risk Factors | 2019 |
Two-carbon folate cycle of commensal Lactobacillus reuteri 6475 gives rise to immunomodulatory ethionine, a source for histone ethylation.
Topics: Amino Acids; Carbon; Cell Proliferation; Cells, Cultured; Culture Media; Ethionine; Folic Acid; Histones; Homocysteine; Humans; Immunomodulation; Limosilactobacillus reuteri; Methionine; Methylation; Microbiota; Probiotics; THP-1 Cells; Tumor Necrosis Factor-alpha | 2019 |
The immunomodulatory mechanism of brain injury induced by hyperhomocysteinemia in spontaneously hypertensive rats.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Forkhead Transcription Factors; Homocysteine; Humans; Hyperhomocysteinemia; Immunomodulation; Inflammation; Interleukin-10; Interleukin-17; Interleukin-6; Methionine; Nuclear Receptor Subfamily 1, Group F, Member 3; Rats; Rats, Inbred SHR; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Transforming Growth Factor beta | 2019 |
Altered Methionine Metabolism in Cancer Cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Homocysteine; Humans; Methionine; Methylation; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine | 2019 |
Total Methionine Restriction Treatment of Cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Choline; Homocysteine; Humans; Liver; Methionine; Mice, Nude; Neoplasms; Temozolomide; Xenograft Model Antitumor Assays | 2019 |
Newborn screening for homocystinurias: Recent recommendations versus current practice.
Topics: Acetylcarnitine; Amino Acid Metabolism, Inborn Errors; Carnitine; Female; Glycine N-Methyltransferase; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Muscle Spasticity; Neonatal Screening; Phenylalanine; Psychotic Disorders | 2019 |
Maternal betaine status, but not that of choline or methionine, is inversely associated with infant birth weight.
Topics: Adult; Betaine; Birth Weight; Choline; Female; Homocysteine; Humans; Infant, Newborn; Infant, Small for Gestational Age; Male; Maternal Nutritional Physiological Phenomena; Methionine; Pregnancy; Pregnancy Trimesters; Sarcosine | 2019 |
Identification and characterization of Helicobacter pylori O-acetylserine-dependent cystathionine β-synthase, a distinct member of the PLP-II family.
Topics: Bacterial Proteins; Binding Sites; Catalytic Domain; Cystathionine; Cystathionine beta-Synthase; Enzyme Stability; Helicobacter pylori; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Methionine; Serine; Substrate Specificity | 2019 |
[Effects of methionine on the activity of cystathionine-β-synthase].
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine; Cystathionine beta-Synthase; Homocysteine; Liver; Male; Methionine; Rats; Rats, Wistar | 2019 |
Association between polymorphisms of a folate - homocysteine - methionine - SAM metabolising enzyme gene and multiple sclerosis in a Polish population.
Topics: Adult; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Multiple Sclerosis; Poland | 2019 |
The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Autism Spectrum Disorder; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cystathionine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Male; Mass Spectrometry; Methionine; Methylation; Mutation; Oxidation-Reduction; Phenotype; Vitamin B 12; Vitamin B 6 | 2019 |
Association of Methionine to Homocysteine Status With Brain Magnetic Resonance Imaging Measures and Risk of Dementia.
Topics: Aged; Aged, 80 and over; Atrophy; Biomarkers; Brain; Case-Control Studies; Dementia; Female; Homocysteine; Humans; Incidence; Longitudinal Studies; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Organ Size; Risk Factors; Sweden | 2019 |
A novel approach in the management of hyperhomocysteinemia.
Topics: Alcohol Oxidoreductases; Animals; Choline; Cytidine Diphosphate Choline; Dietary Supplements; Endothelial Cells; Folic Acid; Homocysteine; Humans; Hydrolysis; Hyperhomocysteinemia; Kidney; Life Style; Liver; Methionine; Models, Theoretical; Vitamin B 12; Vitamin B 6 | 2019 |
Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling.
Topics: Cytosol; Gene Regulatory Networks; Histones; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Protein Interaction Maps; Protein Transport | 2020 |
[Homoarginine level and methionine-homocysteine balance in patients with ischemic heart disease.]
Topics: Aged; Biomarkers; Case-Control Studies; Female; Homoarginine; Homocysteine; Humans; Male; Methionine; Middle Aged; Myocardial Ischemia | 2019 |
S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset.
Topics: Amyloid Neuropathies, Familial; Cardiomyopathies; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Homocysteine; Humans; Methionine; Mutation; Myocytes, Cardiac; Prealbumin; Protein Conformation; Protein Stability; Stroke; Structure-Activity Relationship | 2020 |
Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b/SP1 pathway.
Topics: Animals; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Diet; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Down-Regulation; Foam Cells; HEK293 Cells; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Plaque, Atherosclerotic; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Sp1 Transcription Factor; THP-1 Cells | 2020 |
Early treatment using betaine and methionine for a neonate with MTHFR deficiency.
Topics: Betaine; Homocysteine; Homocystinuria; Humans; Infant; Infant, Newborn; Japan; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Psychotic Disorders; Treatment Outcome | 2019 |
Novel method for l-methionine determination using l-methionine decarboxylase and application of the enzyme for l-homocysteine determination.
Topics: Amino Acid Metabolism, Inborn Errors; Carbon-Sulfur Lyases; Carboxy-Lyases; Enzyme Assays; Escherichia coli; Glycine N-Methyltransferase; Homocysteine; Homocystinuria; Humans; Methionine; Plasmids; Pseudomonas putida; Spectrophotometry; Streptomyces | 2020 |
Identification and characterization of a bacterial core methionine synthase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bacterial Proteins; Chloroflexi; Dehalococcoides; Escherichia coli; Genome, Bacterial; Homocysteine; Methionine; Methylation; Phylogeny; Vitamin B 12 | 2020 |
Dietary methionine restriction improves the impairment of cardiac function in middle-aged obese mice.
Topics: Animals; Body Weight; Cardiomegaly; Diet; Energy Metabolism; Homocysteine; Hydrogen Sulfide; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Obese; Myocardium; Obesity; Oxidative Stress | 2020 |
Effect of post-ruminal guanidinoacetic acid supplementation on creatine synthesis and plasma homocysteine concentrations in cattle.
Topics: Abomasum; Animal Feed; Animals; Arginine; Cattle; Creatine; Diet; Dietary Supplements; Female; Glycine; Homocysteine; Medicago sativa; Methionine; Random Allocation; Zea mays | 2020 |
Induced DNA hypomethylation by Folic Acid Deprivation in Bovine Fibroblast Donor Cells Improves Reprogramming of Somatic Cell Nuclear Transfer Embryos.
Topics: Animals; Cattle; Cells, Cultured; DNA Methylation; Embryo, Mammalian; Female; Fibroblasts; Folic Acid; Gene Expression; Homocysteine; Methionine; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Promoter Regions, Genetic | 2020 |
Hyperhomocysteinemia-Induced Oxidative Stress Exacerbates Cortical Traumatic Brain Injury Outcomes in Rats.
Topics: Animals; Anxiety; Behavior, Animal; Blood Coagulation; Blood-Brain Barrier; Brain Injuries, Traumatic; Cerebral Cortex; Homocysteine; Hyperhomocysteinemia; Inflammation; Intercellular Adhesion Molecule-1; Male; Methionine; Occludin; Oxidative Stress; Rats, Sprague-Dawley; Tyrosine; Zonula Occludens-1 Protein | 2021 |
Association of Homocysteine, Methionine, and MTHFR 677C>T Polymorphism With Rate of Cardiovascular Multimorbidity Development in Older Adults in Sweden.
Topics: Age Factors; Aged; Cardiovascular Diseases; Female; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Multimorbidity; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; Sweden | 2020 |
An accurate and sensitive analytical method for the simultaneous determination of glycine, methionine and homocysteine in biological matrices by matrix matching strategy and LC-quadrupole-time-of-flight-MS/MS.
Topics: Chromatography, Liquid; Glycine; Homocysteine; Humans; Limit of Detection; Methionine; Reproducibility of Results; Tandem Mass Spectrometry | 2020 |
Laboratory evaluation of homocysteine remethylation disorders and classic homocystinuria: Long-term follow-up using a cohort of 123 patients.
Topics: Betaine; Cystathionine beta-Synthase; Follow-Up Studies; Homocysteine; Homocystinuria; Humans; Laboratories; Methionine; Methylation | 2020 |
Effect of Methionine Diet on Time-Related Metabolic and Histopathological Changes of Rat Hippocampus in the Model of Global Brain Ischemia.
Topics: Animals; Brain Ischemia; Diet; Hippocampus; Homocysteine; Hyperhomocysteinemia; Magnetic Resonance Spectroscopy; Male; Methionine; Rats; Rats, Wistar | 2020 |
Interplay of Enzyme Therapy and Dietary Management of Murine Homocystinuria.
Topics: Animals; Betaine; Cystathionine beta-Synthase; Enzyme Therapy; Female; Homocysteine; Homocystinuria; Humans; Male; Methionine; Mice; Recombinant Proteins | 2020 |
[Remethylation disorders: about two cases].
Topics: Alcoholism; Amino Acid Metabolism, Inborn Errors; Diagnosis, Differential; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Metabolic Networks and Pathways; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Muscle Spasticity; Psychotic Disorders; Vitamin B 12 | 2020 |
Liver transplant as a curative treatment in a pediatric patient with classic homocystinuria: A case report.
Topics: Cystathionine beta-Synthase; Female; Homocysteine; Homocystinuria; Humans; Infant; Infant, Newborn; Liver Transplantation; Male; Methionine; Neonatal Screening; Pediatrics | 2021 |
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Topics: Adenosylhomocysteinase; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Enzymologic; Glycine Hydroxymethyltransferase; Homocysteine; Homocystinuria; Humans; Liver; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Polyamines | 2021 |
Four families of folate-independent methionine synthases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Archaeal Proteins; Bacterial Proteins; Biosynthetic Pathways; Folic Acid; Homocysteine; Iron-Sulfur Proteins; Methionine; Models, Chemical; Molecular Structure; Multigene Family; Oxygen; Tetrahydrofolates; Vitamin B 12 | 2021 |
Differences in cell death in methionine versus cysteine depletion.
Topics: Activating Transcription Factor 4; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chemotherapy, Adjuvant; Cysteine; Ferroptosis; Gene Expression Regulation, Neoplastic; Homocysteine; Humans; Lipid Peroxidation; Melanoma; Methionine; NF-E2-Related Factor 2; Transcriptome | 2021 |
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran.
Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult | 2021 |
Methionine Diet Evoked Hyperhomocysteinemia Causes Hippocampal Alterations, Metabolomics Plasma Changes and Behavioral Pattern in Wild Type Rats.
Topics: Animals; Behavior, Animal; Hippocampus; Homocysteine; Hyperhomocysteinemia; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methionine; Rats, Wistar; Staining and Labeling | 2021 |
Addition of dietary methionine but not dietary taurine or methyl donors/receivers to a grain-free diet increases postprandial homocysteine concentrations in adult dogs.
Topics: Animals; Diet; Dietary Supplements; Dogs; Edible Grain; Homocysteine; Methionine; Taurine | 2021 |
Methionine synthase deficiency: Variable clinical presentation and benefit of early diagnosis and treatment.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Amino Acid Metabolism, Inborn Errors; Early Diagnosis; Homocysteine; Humans; Metabolism, Inborn Errors; Methionine; Vitamin B 12 | 2022 |
Characterization and application of l-methionine γ-lyase Q349S mutant enzyme with an enhanced activity toward l-homocysteine.
Topics: Carbon-Sulfur Lyases; Homocysteine; Methionine; Pseudomonas putida; Pyridoxal Phosphate | 2022 |
A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice.
Topics: Amino Acids; Animals; Bipolar Disorder; Disease Models, Animal; Drug Administration Schedule; Homocysteine; Male; Methionine; Mice; Open Field Test; Up-Regulation | 2022 |
Simultaneous determination of serum homocysteine, cysteine, and methionine in patients with schizophrenia by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Cysteine; Homocysteine; Humans; Methionine; Schizophrenia; Tandem Mass Spectrometry | 2022 |
Homocysteine facilitates endoplasmic reticulum stress and apoptosis of hepatocytes by suppressing ERO1α expression via cooperation between DNMT1 and G9a.
Topics: Animals; Apoptosis; DNA (Cytosine-5-)-Methyltransferase 1; Endoplasmic Reticulum Stress; Hepatocytes; Histone-Lysine N-Methyltransferase; Homocysteine; Methionine; Mice; Oxidoreductases | 2022 |
Establishment of reference intervals of homocysteine, cysteine, and methionine in apparently healthy Chinese adults.
Topics: Adult; Biomarkers; China; Chromatography, Liquid; Cysteine; Female; Homocysteine; Humans; Male; Methionine; Tandem Mass Spectrometry | 2022 |
Did Homocysteine Take Part in the Start of the Synthesis of Peptides on the Early Earth?
Topics: Cysteine; Homocysteine; Methionine; Peptides; Sulfhydryl Compounds | 2022 |
[Clinical characteristics and CBS gene analysis of 13 cases with classic homocystinuria].
Topics: Adolescent; Child; Child, Preschool; Cystathionine beta-Synthase; Female; Homocysteine; Homocystinuria; Humans; Infant; Infant, Newborn; Male; Methionine; Pyridoxine; Retrospective Studies; Vitamins | 2022 |
Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort.
Topics: Aged; Betaine; Biomarkers; Carnitine; Choline; Cohort Studies; Cysteine; Diabetes Mellitus, Type 2; Female; Heart Failure; Homocysteine; Hospitalization; Humans; Male; Methionine; Middle Aged; Prospective Studies; Risk Factors | 2022 |
A quantitative metabolomics assay targeting 14 intracellular metabolites associated with the methionine transsulfuration pathway using LC-MS/MS in breast cancer cells.
Topics: Breast Neoplasms; Chromatography, Liquid; Cysteine; Cystine; Female; Glutathione; Homocysteine; Humans; Metabolomics; Methionine; Tandem Mass Spectrometry | 2022 |
Vitamin B
Topics: Animals; Fatty Acids; Fibrosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Qa-SNARE Proteins; Vitamin B 12; Vitamins | 2022 |
The Association of Homocysteine and Diabetic Retinopathy in Homocysteine Cycle in Chinese Patients With Type 2 Diabetes.
Topics: Asian People; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Homocysteine; Humans; Methionine; Risk Factors | 2022 |
A sensitive UPLC-MS/MS method for simultaneous quantification of one-carbon metabolites & co-factors in human plasma.
Topics: Carbon; Chromatography, High Pressure Liquid; Chromatography, Liquid; Colorectal Neoplasms; Cystathionine; Homocysteine; Humans; Methionine; Tandem Mass Spectrometry | 2022 |
Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran.
Topics: Clinical Trials as Topic; Cystathionine beta-Synthase; Folic Acid; Heme; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Porphyrias, Hepatic; Pyridoxine; RNA, Small Interfering; Sulfur; Vitamin B 6 | 2022 |
Effect of guanidinoacetic acid supplementation on nitrogen retention and methionine methyl group flux in growing steers fed corn-based diets.
Topics: Animals; Arginine; Cattle; Creatine; Creatinine; Diet; Dietary Supplements; Haptoglobins; Homocysteine; Methionine; Nitrogen; Racemethionine; Urea; Zea mays | 2022 |
Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Caenorhabditis elegans; Carbon; Dithiothreitol; Folic Acid; Homocysteine; Hydrogen Sulfide; Ligases; Lipids; Mercaptoethanol; Methionine; Methyltransferases; Nucleic Acids; Oxygen; Reducing Agents; S-Adenosylmethionine; Sulfhydryl Compounds; Vitamin B 12; Vitamins | 2022 |
Methionine and total homocysteine in hypertensive patients with renal excretory dysfunction.
Topics: Homocysteine; Humans; Hypertension; Methionine; Proteinuria; Racemethionine; Renal Insufficiency, Chronic; Sulfur | 2022 |
Betaine supplementation improves positive symptoms in schizophrenia.
Topics: Betaine; Dietary Supplements; Homocysteine; Humans; Methionine; Schizophrenia | 2022 |
Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress.
Topics: Cysteine; Endoplasmic Reticulum Stress; Homocysteine; Humans; Leptin; Methionine; Neuroblastoma; Obesity; Receptors, Leptin; STAT3 Transcription Factor | 2022 |
Quantitative fusion omics reveals that refrigeration drives methionine degradation through perturbing 5-methyltetrahydropteroyltriglutamate-homocysteine activity.
Topics: Amines; Camellia sinensis; Homocysteine; Methionine; Plant Leaves; Refrigeration; Tea | 2023 |
Profiling of Homocysteine Metabolic Pathway Related Metabolites in Plasma of Diabetic Mellitus Based on LC-QTOF-MS.
Topics: Choline; Cysteine; Diabetes Mellitus; Homocysteine; Humans; Metabolic Networks and Pathways; Methionine; Racemethionine; Taurine | 2023 |
Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.
Topics: Adult; Carbon; Child; Chromatography, Liquid; Female; Homocysteine; Humans; Infant; Methionine; Milk, Human; Racemethionine; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2023 |
Lack of Association of
Topics: Breast Neoplasms; Female; Homocysteine; Humans; Mali; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); S-Adenosylmethionine | 2023 |
Optimization of Hydrogenobyrinic Acid Synthesis in a Cell-Free Multienzyme Reaction by Novel
Topics: Cell-Free System; Homocysteine; Methionine; Methyltransferases; S-Adenosylmethionine | 2023 |
The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study.
Topics: Amino Acids, Sulfur; Cardiovascular Diseases; Cross-Sectional Studies; Cystathionine; Cysteine; Diabetes Mellitus, Type 2; Diet; Female; Homocysteine; Humans; Methionine; Obesity; Taurine | 2023 |
Effect of Ethanol-Induced Methyl Donors Consumption on the State of Hypomethylation in Cervical Cancer.
Topics: Animals; Cell Line, Tumor; DNA; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Methionine; Mice; RNA, Messenger; Uterine Cervical Neoplasms | 2023 |
Enzymatic Synthesis of l-Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade.
Topics: Alkylation; Catalysis; Homocysteine; Homoserine; Methionine; Methyltransferases; S-Adenosylmethionine | 2023 |
An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract.
Topics: Animals; Cystathionine beta-Synthase; Gastrointestinal Tract; Homocysteine; Homocystinuria; Humans; Methionine; Mice; Racemethionine | 2023 |
A Methionine-Portioning-Based Medical Nutrition Therapy with Relaxed Fruit and Vegetable Consumption in Patients with Pyridoxine-Nonresponsive Cystathionine-β-Synthase Deficiency.
Topics: Cystathionine; Cystathionine beta-Synthase; Diet, Protein-Restricted; Fruit; Homocysteine; Homocystinuria; Humans; Methionine; Pyridoxine; Racemethionine; Vegetables | 2023 |
The importance of preconception Hcy testing: identification of a folate trap syndrome in a woman attending an assisted reproduction program.
Topics: Female; Folic Acid; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Reproduction; S-Adenosylmethionine | 2023 |
[Association between maternal plasma one-carbon biomarkers during pregnancy and fetal growth in twin pregnancies].
Topics: Adult; Betaine; Biomarkers; Birth Weight; Choline; Cohort Studies; Female; Fetal Development; Fetal Weight; Homocysteine; Humans; Infant, Newborn; Methionine; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Pregnancy, Twin | 2023 |
Thiol reductive stress activates the hypoxia response pathway.
Topics: Animals; Antioxidants; Caenorhabditis elegans; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Homocysteine; Humans; Hypoxia; Methionine | 2023 |
Methionine sources at different dietary levels alters the growth and expression of genes related to homocysteine remethylation in the jejunum of broilers.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chickens; Diet; Dietary Supplements; Homocysteine; Jejunum; Male; Methionine; Racemethionine; Weight Gain | 2023 |