homocysteine and heme

homocysteine has been researched along with heme in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.55)18.2507
2000's7 (31.82)29.6817
2010's7 (31.82)24.3611
2020's7 (31.82)2.80

Authors

AuthorsStudies
Bukovska, G; Kery, V; Kraus, JP1
Finkelstein, JD1
Bruno, S; Burkhard, P; Janosik, M; Kraus, JP; Mozzarelli, A; Schiaretti, F1
Banerjee, R; Green, EL; Loehr, TM; Taoka, S2
Banerjee, R; Taoka, S1
Dwyer, BE; Perry, G; Smith, MA; Takeda, A; Zhu, X1
Kraus, JP; Kruger, WD; Majtan, T; Singh, LR; Wang, L1
Nakahara, A; Ozaki, S; Sakaguchi, C; Yoshiya, M1
Beckerich, JM; Casaregola, S; Hébert, A1
Banerjee, R; Yadav, PK1
Banerjee, R; Kabil, O; Yadav, V1
Andriamihaja, M; Artaud, I; Blachier, F; Castillo, FT; Galardon, E; Hessani, A; Lan, A; Liot, G; Padovani, D; Pilati, C; Sen, S1
Sharma, GS; Singh, LR1
Chen, N; Qiao, Z; Wang, C1
Brewer, CT; Chen, T; Kodali, K; Peng, J; Shaw, TI; Wu, J1
Astegno, A; Conter, C; Dominici, P; Fernández-Rodríguez, C; Fruncillo, S; Martínez-Cruz, LA1
Batlle, A; Cerbino, GN; Granata, BX; Martinez, MDC; Parera, VE; Rossetti, MV1
Aarsand, AK; Aguilera, P; Brunet, M; Deulofeu, R; García-Villoria, J; Gómez-Gómez, À; Pozo, OJ; Sandberg, S; To-Figueras, J; Wijngaard, R1
Beykirch, MK; Klein, M; Loehr, C; Molitor, B; Obermeier, Z; Petrides, PE; Schuhmann, E; Torkler, H1
Badawy, AA1
Balwani, M; Fanelli, MJ; Gouya, L; Longo, N; Petrides, PE; Phillips, J; Plutzky, J; Rhyee, S; Sardh, E; Sweetser, MT; Ventura, P1

Reviews

2 review(s) available for homocysteine and heme

ArticleYear
Pathways and regulation of homocysteine metabolism in mammals.
    Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3

    Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Homocysteine; Isoenzymes; Kinetics; Mammals; Methionine; Methionine Adenosyltransferase; Organ Specificity; Oxidation-Reduction; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tetrahydrofolates

2000
Ferric cycle activity and Alzheimer disease.
    Current neurovascular research, 2005, Volume: 2, Issue:3

    Topics: Alzheimer Disease; Animals; Brain Chemistry; Cell Cycle; Heme; Homocysteine; Humans; Iron; Models, Biological; Oxidative Stress

2005

Other Studies

20 other study(ies) available for homocysteine and heme

ArticleYear
Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein.
    The Journal of biological chemistry, 1994, Oct-14, Volume: 269, Issue:41

    Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Escherichia coli; Heme; Hemeproteins; Homocysteine; Humans; Kinetics; Liver; Pyridoxal Phosphate; Rats; Recombinant Proteins; Serine; Spectrophotometry; Sulfur

1994
Functional properties of the active core of human cystathionine beta-synthase crystals.
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Binding Sites; Carbon Monoxide; Cystathionine beta-Synthase; Heme; Homocysteine; Humans; Microspectrophotometry; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins; Serine; Structure-Activity Relationship

2001
Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme.
    Biochemistry, 2001, Jan-16, Volume: 40, Issue:2

    Topics: Binding, Competitive; Carbon Monoxide; Cystathionine beta-Synthase; Cysteine; Ferric Compounds; Ferrous Compounds; Heme; Homocysteine; Humans; Iron-Sulfur Proteins; Ligands; Mercuric Chloride; Molybdenum; Oxidation-Reduction; Protein Binding; Pyridoxal Phosphate; Spectrum Analysis, Raman

2001
Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity.
    Journal of inorganic biochemistry, 2001, Dec-15, Volume: 87, Issue:4

    Topics: Cystathionine beta-Synthase; Ferric Compounds; Ferrous Compounds; Heme; Homocysteine; Humans; Mercuric Chloride; Models, Chemical; Oxidation-Reduction; Spectrophotometry; Spectrum Analysis, Raman; Sulfhydryl Compounds

2001
Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase.
    The Journal of biological chemistry, 2002, Jun-21, Volume: 277, Issue:25

    Topics: Catalysis; Cystathionine; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Heme; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Serine; Spectrophotometry; Time Factors

2002
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.
    The Journal of biological chemistry, 2008, Dec-12, Volume: 283, Issue:50

    Topics: Allosteric Site; Cobalt; Cystathionine beta-Synthase; Escherichia coli; Heme; Homocysteine; Humans; Manganese; Metals; Methylamines; Porphyrins; Protein Denaturation; Protein Folding; Recombinant Proteins; S-Adenosylmethionine; Saccharomyces cerevisiae

2008
Mutagenesis studies of human cystathionine beta-synthase: residues important for heme binding and substrate interactions.
    Protein and peptide letters, 2010, Volume: 17, Issue:3

    Topics: Catalytic Domain; Cystathionine beta-Synthase; Heme; Homocysteine; Humans; Hydrogen Sulfide; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Serine; Spectrophotometry; Structure-Activity Relationship

2010
Biodiversity in sulfur metabolism in hemiascomycetous yeasts.
    FEMS yeast research, 2011, Volume: 11, Issue:4

    Topics: Amino Acids, Sulfur; Biodiversity; Cysteine; Genetic Variation; Glucosephosphate Dehydrogenase; Glutathione; Heme; Homocysteine; Methionine; NADP; Phylogeny; Sequence Alignment; Sequence Analysis, Protein; Sulfur; Yeasts

2011
Detection of reaction intermediates during human cystathionine β-synthase-monitored turnover and H2S production.
    The Journal of biological chemistry, 2012, Dec-21, Volume: 287, Issue:52

    Topics: Cystathionine beta-Synthase; Cysteine; Heme; Homocysteine; Humans; Hydrogen Sulfide; Kinetics; Serine

2012
Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress.
    The Journal of biological chemistry, 2016, 08-05, Volume: 291, Issue:32

    Topics: Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Endoplasmic Reticulum Stress; Gene Expression Regulation, Enzymologic; HEK293 Cells; Heme; Heme Oxygenase-1; Homocysteine; Humans; Hydrogen Sulfide; Membrane Proteins; Mice; Mice, Knockout; Signal Transduction; Up-Regulation

2016
Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases.
    Nature communications, 2016, 11-16, Volume: 7

    Topics: Animals; Catalase; Cell Line, Tumor; Chromatography, High Pressure Liquid; Enzyme Activation; Heme; Homocysteine; Hydrogen Sulfide; Iron; Male; Mass Spectrometry; Mice, Inbred C57BL; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; Oxygen; Sulfhydryl Compounds

2016
Conformational status of cytochrome c upon N-homocysteinylation: Implications to cytochrome c release.
    Archives of biochemistry and biophysics, 2017, Jan-15, Volume: 614

    Topics: Animals; Apoptosis; Cardiolipins; Cattle; Circular Dichroism; Cytochromes c; Electron Spin Resonance Spectroscopy; Heme; Homocysteine; Iron; Ligands; Methionine; Myocardium; Oxygen; Peroxidase; Peroxidases; Protein Conformation; Protein Processing, Post-Translational; Spectrophotometry, Ultraviolet

2017
A chemoselective reaction between protein N-homocysteinylation and azides catalyzed by heme(ii).
    Chemical communications (Cambridge, England), 2019, Mar-21, Volume: 55, Issue:25

    Topics: Animals; Azides; Biotin; Catalysis; Cattle; Heme; Homocysteine; Hydrogen-Ion Concentration; Myoglobin; Peptides; Protein Processing, Post-Translational; Proteins; Serum Albumin, Bovine; Tandem Mass Spectrometry; Temperature

2019
Toxicoproteomic Profiling of
    Cells, 2020, 07-09, Volume: 9, Issue:7

    Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Heme; Homocysteine; Iron-Sulfur Proteins; Isoniazid; Liver; Mice; Mice, Inbred C57BL; Niacinamide; Oxidative Stress; Proteome; Rifampin; Vitamin B 6

2020
Cystathionine β-synthase is involved in cysteine biosynthesis and H
    Scientific reports, 2020, 09-04, Volume: 10, Issue:1

    Topics: Biocatalysis; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; DNA, Complementary; Genes, Protozoan; Heme; Homocysteine; Hydrogen Sulfide; Kinetics; Serine; Toxoplasma

2020
Clinical, biochemical, and genetic characterization of acute hepatic porphyrias in a cohort of Argentine patients.
    Molecular genetics & genomic medicine, 2021, Volume: 9, Issue:5

    Topics: Argentina; Female; Heme; Homocysteine; Humans; Male; Mutation; Oxidative Stress; Porphyrias, Hepatic

2021
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran.
    Journal of inherited metabolic disease, 2021, Volume: 44, Issue:4

    Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult

2021
Severe homocysteinemia in two givosiran-treated porphyria patients: is free heme deficiency the culprit?
    Annals of hematology, 2021, Volume: 100, Issue:7

    Topics: 5-Aminolevulinate Synthetase; Acetylgalactosamine; Adult; Arginine; Colitis; Colon, Sigmoid; Controlled Clinical Trials as Topic; Drug Hypersensitivity; Female; Fibrosis; Heme; Hepatocytes; High-Throughput Nucleotide Sequencing; Homocysteine; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Models, Biological; Pancreatitis; Porphyria, Acute Intermittent; Pyrrolidines

2021
Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.
    Bioscience reports, 2021, 07-30, Volume: 41, Issue:7

    Topics: Animals; Cystathionine beta-Synthase; Heme; Hemin; Homocysteine; Humans; Kynurenine; Nutritional Status; Porphyrias, Hepatic; Treatment Outcome; Tryptophan; Vitamin B Complex

2021
Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran.
    Expert review of gastroenterology & hepatology, 2022, Volume: 16, Issue:9

    Topics: Clinical Trials as Topic; Cystathionine beta-Synthase; Folic Acid; Heme; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Porphyrias, Hepatic; Pyridoxine; RNA, Small Interfering; Sulfur; Vitamin B 6

2022