homocysteine has been researched along with folic acid in 3816 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 102 (2.67) | 18.7374 |
| 1990's | 433 (11.35) | 18.2507 |
| 2000's | 1915 (50.18) | 29.6817 |
| 2010's | 1086 (28.46) | 24.3611 |
| 2020's | 280 (7.34) | 2.80 |
| Authors | Studies |
|---|---|
| Das, KC; Herbert, V | 1 |
| Erbe, RW; Hoffman, RM | 1 |
| Jacobsen, SJ; Mangum, JH; North, JA; Rao, NA | 1 |
| Benesh, FC; Carl, GF | 1 |
| Canfield, CJ; McCormick, GJ; Smith, CC | 1 |
| Osifo, BO | 1 |
| Hems, R; Krebs, HA | 1 |
| Finkelstein, JD; Freeman, JM; Mudd, SH | 1 |
| Hanna, LM; Taylor, RT | 1 |
| Cheng, FW; Shane, B; Stokstad, EL | 1 |
| Caboche, M | 1 |
| Hieb, WF; Lu, NC; Stokstad, EL | 1 |
| Andersson, A; Brattström, L; Hultberg, B; Israelsson, B; Olsson, A | 1 |
| Mason, JB; Miller, JW | 1 |
| Lewis, CA; Pancharuniti, N; Sauberlich, HE | 1 |
| Holm, AC; Lassvik, C; Malinow, MR; Mölgaard, J; Olsson, AG; Upson, B | 1 |
| Harvison, PJ; Kalman, TI | 1 |
| Andersson, A; Brattström, L; Hamfelt, A; Hultberg, B; Isaksson, A; Israelsson, B | 1 |
| Brattström, L; Hamfelt, A; Israelsson, B; Lindgren, A; Malinow, MR; Norrving, B; Upson, B | 1 |
| Christensen, B; Garras, A; Refsum, H; Ueland, PM | 1 |
| Allen, RH; Brass, EP; Marcell, PD; Stabler, SP | 1 |
| Brattström, L; Hultberg, B; Israelsson, B; Lagerstedt, C; Tengborn, L | 1 |
| Olszewski, AJ | 1 |
| Baggott, JE; Morgan, SL; Refsum, H; Ueland, PM | 1 |
| Refsum, H; Ueland, PM; Wesenberg, F | 1 |
| Bock, HG; Grix, A; Horwitz, A; Kang, SS; Wong, PW | 1 |
| Abels, J; Ermens, AA; Guttormsen, AB; Lindemans, J; Refsum, H; Rupreht, J; Spijkers, LJ; Ueland, PM | 1 |
| Chu, RC; Hall, CA | 2 |
| Allen, RH; Lindenbaum, J; Savage, DG; Stabler, SP | 3 |
| Bergqvist, D; Brattström, L; Hamfelt, A; Hultberg, B; Israelsson, B; Norrving, B; Thörne, J | 1 |
| Lapin, IP; Ryzhov, IV | 1 |
| Kang, SS; Lin, JY; Wong, PW; Zhou, JM | 2 |
| Bialkowska, M; McCully, KS; Olszewski, AJ; Rudnicki, S; Szostak, WB | 1 |
| Boss, GR | 1 |
| Dudman, NP; Tyrrell, PA; Wilcken, DE | 2 |
| Brattström, LE; Hultberg, BL; Israelsson, B; Jeppsson, JO | 1 |
| Dudman, NP; Robertson, MR; Tyrrell, PA; Wilcken, DE | 1 |
| Kang, SS; Norusis, M; Wong, PW | 1 |
| Brattström, LE; Hardebo, JE; Hultberg, BL | 1 |
| Barak, AJ; Beckenhauer, HC; Tuma, DJ | 2 |
| Gawthorne, JM; Smith, RM | 1 |
| Beaton, JM; Bradley, RJ; Bridgers, WF; McClain, LD; Pegram, GV; Smythies, JR | 1 |
| Foster, MA; Guest, JR; Woods, DD | 1 |
| Daniel, LJ; Griffiths, JM | 1 |
| Ritari, SJ; Rosales, F; Sakami, W | 1 |
| Kutzbach, C; Stokstad, EL | 2 |
| Batra, KK; Buehring, KU; Stokstad, EL | 2 |
| Freeman, JM; Mudd, SH | 1 |
| Erbe, RW; Kamely, D; Littlefield, JW | 1 |
| Sviatkina, OB; Vel'tishchev, IuE | 1 |
| Greene, RC; Kung, HF; Spears, C; Weissbach, H; Williams, RD | 1 |
| Foster, MA; Pattison, JR; Salem, AR | 1 |
| Turner, B; Wilcken, B | 1 |
| Stokstad, EL; Thenen, SW | 1 |
| Howell, JN; Jaenicke, L; Sauer, H | 1 |
| Levitch, ME; Wagner, C | 1 |
| Taylor, RT; Weissbach, H | 5 |
| Taylor, RT; Weissbach, H; Whitfield, C | 1 |
| Weissbach, H; Whitfield, CD | 2 |
| Bertino, JR; Hillcoat, BL | 1 |
| Burton, E; Sakami, W; Selhub, J | 1 |
| Jaenicke, L; Rüdiger, H | 1 |
| Steers, EJ; Weissbach, H; Whitfield, CD | 1 |
| Hanna, ML; Taylor, RT | 2 |
| Corcino, JJ; Herbert, V; Waxman, S | 1 |
| Rüdiger, H | 1 |
| Taylor, RT | 2 |
| Dawes, J; Foster, MA | 1 |
| Cossins, EA; Dodd, WA | 1 |
| Parker, DJ; Wood, HG; Wu, TF | 1 |
| Dewey, VC; Kidder, GW | 1 |
| Finkelstein, JD; Freeman, JM; Mudd, SH; Shih, VE; Uhlendorf, BW | 1 |
| Mangum, JH; North, JA; Steuart, BW | 1 |
| Draper, MW; Mangum, JH; North, JA | 1 |
| Barness, LA; Morrow, G | 1 |
| Mangum, JH; North, JA | 1 |
| Brodie, JD; Burke, GT; Mangum, JH | 2 |
| Mahoney, MJ; Mudd, SH; Rosenberg, LE; Uhlendorf, BW | 1 |
| Foster, MA; Friedman, S; Guest, JR; Tejerina, G; Woods, DD | 1 |
| Spatz, R | 1 |
| Mangum, JH; Murray, BK; North, JA | 1 |
| Foster, MA; Salem, AR; Wilson, RH | 1 |
| Fujii, K; Fukui, S | 1 |
| Levy, H; Morrow, G; Mudd, SH | 1 |
| Hinds, KR; Mudd, SH; Uhlendorf, BW | 1 |
| Goodman, SI; Hammond, KB; Moe, PG; Mudd, SH; Uhlendorf, BW | 1 |
| Kerwar, SS; McAuslan, B; Spears, C; Weissbach, H | 1 |
| Sovik, O | 1 |
| Daniel, LJ; Lust, G | 1 |
| Erbe, RW; Wang, JC | 2 |
| Houghton, JA; Houghton, PJ; Schmidt, C | 1 |
| Wickramasinghe, SN | 1 |
| Betts, AK; Gupta, VJ; Wilcken, DE | 1 |
| Dwyer, JT; Friedman, JA | 1 |
| Alonso-Aperte, E; Alvarez, L; Caballería, J; Deulofeu, R; Gassó, M; Mato, JM; Rodés, J; Rubio, M; Varela-Moreiras, G | 1 |
| Bailey, LB; Cerda, JJ; Davis, BA; Gregory, JF; Hofler, SA; O'Keefe, CA; Thomas, EA | 1 |
| Beresford, SA; Boushey, CJ; Motulsky, AG; Omenn, GS | 1 |
| Blom, HJ; den Heyer, M; Eskes, TK; Frosst, P; Mariman, EC; Rozen, R; Steegers-Theunissen, RP; Trijbels, FJ; van den Heuvel, LP; van der Put, NM | 1 |
| Becker, PJ; Delport, R; Potgieter, H; Ubbink, JB; van der Merwe, A; Vermaak, WJ | 1 |
| Allen, RH; Joosten, E; Lindenbaum, J; Naurath, HJ; Riezler, R; Stabler, SP | 1 |
| Anda, RF; Casper, ML; Croft, JB; Giles, WH; Kittner, SJ | 1 |
| Blom, HJ; De Abreu, RA; Eskes, TK; Herberts, CA; Noordhoek, J; Peereboom-Stegeman, JH; Poirot, CM; Trijbels, JM; VanAerts, LA | 1 |
| Malinow, MR; Stampfer, MJ | 1 |
| Hopkins, PN; Hunt, SC; James, BC; Vincent, GM; Williams, RR; Wu, J; Wu, LL | 1 |
| Andersson, A; Brattström, L; Hultberg, B; Israelsson, B; Landgren, F; Lindgren, A | 1 |
| Conley, MR; Kirke, PN; Lee, YJ; McPartlin, JM; Mills, JL; Scott, JM; Weir, DG | 1 |
| Blom, HJ; Boers, GH; Borm, GF; Eskes, TK; Nijhuis, JG; Steegers-Theunissen, RP; Thomas, CM | 1 |
| Allen, RH; Bostom, AG; Nadeau, MR; Selhub, J; Shemin, D; Shih, V; Stabler, SP | 1 |
| Dalery, K; Davignon, J; Genest, J; Latour, Y; Lussier-Cacan, S; Selhub, J | 1 |
| Blom, HJ; Boers, GH; Franken, DG; Jakobs, C; Kluft, C; Rauwerda, JA; Stehouwert, CD; Van den Berg, M; Van Kamp, GJ | 1 |
| Boers, GH; Janssen, MJ; Stehouwer, CD; van den Berg, M | 1 |
| Glueck, CJ; Lang, JE; Shaw, P; Sieve-Smith, L; Tracy, T; Wang, Y | 1 |
| Belanger, AJ; Bostom, AG; D'Agostino, RB; Jacques, PF; O'Leary, DH; Rosenberg, IH; Schaefer, EJ; Selhub, J; Wilson, PW; Wolf, PA | 1 |
| Andersson, A; Fäldt, R; Gustafson, L; Hultberg, B; Nilsson, K | 1 |
| Anker, G; Lien, EA; Lønning, PE; Refsum, H; Ueland, PM | 1 |
| Berger, PB; Daly, RC; Edwards, BS; Frantz, RP; Jones, JD; Kottke, BA; McGregor, CG; Olson, LJ; Rodeheffer, RJ | 1 |
| Ubbink, JB | 2 |
| Bennie, A; Gangaidzo, I; Gwanzura, C; Kiire, C; Lindenbaum, J; Moyo, A; Mudenge, B; Mukiibi, JM; Savage, D; Sitima, J | 1 |
| García-Cuevas, M; Pérez-Olleros, L; Ruiz-Roso, B; Varela-Moreiras, G | 1 |
| Carson, W; Chadefaux, B; Cooper, BA; Gavsie, A; Gilfix, BM; Lue-Shing, H; Rosenblatt, DS | 1 |
| Becker, PJ; Delport, R; Potgieter, HC; Ubbink, JB; van der Merwe, A; Vermaak, WJ | 1 |
| Fiskerstrand, T; Guttormsen, AB; Refsum, HM; Schneede, J; Ueland, PM | 1 |
| Boers, GH; Janssen, MJ; Stehouwer, CD; van den Berg, M; van Guldener, C | 1 |
| da Costa, KA; Kim, YI; Mason, JB; Miller, JW; Nadeau, M; Selhub, J; Smith, D; Zeisel, SH | 1 |
| Andersson, A; Brattström, L; Hultberg, B; Israelsson, B; Lindgren, A | 1 |
| Blom, HJ; Boers, GH; Franken, DG; Jakobs, C; Rauwerda, JA; Stehouwer, CD; van den Berg, M | 1 |
| Blom, HJ; Boers, GH; Borm, GF; Eskes, TK; Finkelstein, JD; Steegers-Theunissen, RP; Thomas, CM; Trijbels, FJ; Wouters, MG | 1 |
| Hartley, R; Levene, MI; Lucock, MD; Schorah, CJ; Wild, J | 1 |
| Henning, SM; Jacob, RA; Swendseid, ME; Wu, MM | 1 |
| Blom, HJ; Boers, GH; Franken, DG; Trijbels, JM | 1 |
| Boers, GH | 2 |
| Christensen, B; Fiskerstrand, T; Refsum, H; Tysnes, OB; Ueland, PM | 1 |
| Gatautis, VJ; Green, R; Jacobsen, DW; Ji, J; Otto, JM; Robinson, K; Savon, SR; Secic, M; Taylor, LM | 1 |
| Delport, R; Ubbink, JB; van der Merwe, A; Vermaak, WJ | 1 |
| Jacques, PF; Rosenberg, IH; Rush, D; Selhub, J; Wilson, PW | 1 |
| Acton, RT; Alvarez, JO; Copeland, RB; Cousins, AL; Go, RC; Lewis, CA; Macaluso, M; Pancharuniti, N; Perkins, LL; Sauberlich, HE | 1 |
| Eskes, TK; Steegers-Theunissen, RP | 1 |
| Eskes, TK; Hollanders, HM; Peereboom-Stegeman, JH; Steegers, EA; Steegers-Theunissen, RP; Thomas, CM; Trijbels, FJ | 1 |
| Andersson, A; Arnadottir, M; Brattström, L; Hultberg, B; Nilsson-Ehle, P; Simonsen, O; Thysell, H | 1 |
| Christensen, B; Ueland, PM | 1 |
| Bergmark, C; de Faire, U; Mansoor, MA; Svardal, AM; Swedenborg, J; Ueland, PM | 1 |
| Cabello Tomás, ML; Dalmau Serra, J; García Gómez, AM; Montero Brens, C; Rodes Monegal, M; Vilaseca Busca, A | 1 |
| Becker, PJ; Ubbink, JB; van der Merwe, A; Vermaak, WJ | 1 |
| Eskes, TK; Smithells, RW; Steegers-Theunissen, RP | 1 |
| Pérez de Miguelsanz, J; Ragel, C; Varela-Moreiras, G | 1 |
| Bierdrager, E; Rauwerda, JA; Stehouwer, CD; van den Berg, M | 1 |
| Motulsky, AG | 1 |
| Guttormsen, AB; Refsum, H; Schneede, J; Ueland, PM | 1 |
| Camilo, ME; Cardoso, JN; Cravo, ML; Glória, LM; Leitão, CN; Mira, FC; Nadeau, MR; Resende, MP; Selhub, J | 1 |
| Aukrust, P; Berge, RK; Frøland, SS; Müller, F; Svardal, AM; Ueland, PM | 2 |
| Drown, DJ | 1 |
| Bostom, AG | 2 |
| Appel, LJ | 1 |
| Grunwald, HW; Rosner, F | 1 |
| McCully, KS | 3 |
| Adams, MJ; Dickinson, CM; Oakley, GP | 1 |
| Conley, MR; Kirke, PN; Lee, YJ; McPartlin, JM; Mills, JL; Molloy, AM; Scott, JM; Weir, DG | 1 |
| Dybkjaer, L; Lyngbak, M; Møller, J; Pedersen, AM; Rasmussen, K | 1 |
| Jacobsen, DW; Mayer, EL; Robinson, K | 1 |
| Arnadottir, M; Hultberg, B; Nilsson-Ehle, P; Thysell, H; Vladov, V | 1 |
| Allen, RH; Buring, JE; Gaziano, JM; Hennekens, CH; Kok, FJ; Reynolds, RD; Stabler, SP; Stampfer, MJ; Verhoef, P; Willett, WC | 1 |
| Davis, RE | 1 |
| Bostom, AG; Eckfeldt, JH; Ellison, RC; Jacques, PF; Rosenberg, IH; Rozen, R; Selhub, J; Williams, RR | 1 |
| Allen, RH; Chandler, CJ; Halsted, CH; James, SJ; Muskhelishvili, L; Poirier, L; Stabler, SP; Villanueva, J | 1 |
| Belanger, AJ; Bostom, AG; D'Agostino, RB; Jacques, PF; O'Leary, DH; Rosenberg, IH; Rush, D; Schaefer, EJ; Selhub, J; Wilson, PW; Wolf, PA | 1 |
| Kang, SS | 1 |
| Rimm, EB; Stampfer, MJ | 2 |
| Aupetit, J; Chadefaux, B; Chauveau, P; Coudé, M; Jungers, P; Kamoun, P | 1 |
| de Jong, GM; Donker, AJ; Janssen, MJ; Stehouwer, CD; van den Berg, M; van Guldener, C | 1 |
| Adjalla, C; Belleville, F; Benhayoun, S; Felden, F; Gaucher, P; Gelot, MA; Gerard, P; Guéant, JL; Lambert, D; Nicolas, JP; Renkes, P | 1 |
| Rozen, R | 2 |
| Blom, HJ; Eskes, TK; Monnens, IA; te Poele Pothoff, MT; van den Heuvel, LP; van der Molen, EF | 1 |
| Kim, YI; Logan, JW; Mason, JB; Roubenoff, R | 1 |
| Chasan-Taber, L; Hennekens, CH; Malinow, MR; Rosenberg, IH; Selhub, J; Stampfer, MJ; Terry, P; Tishler, PV; Willett, W | 1 |
| Bostom, AG; Chan, J; Jacques, PF; Lapane, KL; Nadeau, MR; Rosenberg, IH; Rozen, R; Selhub, J; Shemin, D; Sutherland, P; Yoburn, D | 1 |
| Montalescot, G | 1 |
| Graham, IM; Meleady, RA; Mulcahy, DA | 1 |
| Chan, CF; Cheng, SK; Lolin, YI; Masarei, JR; Pang, CP; Sanderson, JE; Woo, KS | 1 |
| Allen, RH; Baumgartner, RN; Garry, PJ; Koehler, KM; Liang, HC; Pareo-Tubbeh, SL; Romero, LJ; Stabler, SP; Stauber, PM | 1 |
| Davignon, J; Genest, J; Lussier-Cacan, S; Piolot, A; Selhub, J; Xhignesse, M | 1 |
| Jacobsen, DW | 1 |
| Arnadottir, M; Hultberg, B; Nilsson-Ehle, P; Thysell, H | 1 |
| Leeming, RJ | 1 |
| Ekelund, S; Krogh Jensen, M; Svendsen, L | 1 |
| Buring, J; Gaziano, JM; Lindpaintner, K; Schmitz, C; Verhoef, P | 1 |
| Joosten, E; Lesaffre, E; Riezler, R | 1 |
| Guttormsen, AB; Nesthus, I; Nygård, O; Refsum, H; Schneede, J; Ueland, PM; Vollset, SE | 1 |
| Andersson, A; Brattström, L; Fäldt, R; Gustafson, L; Hultberg, B; Israelsson, B; Lindgren, A; Nilsson, K | 1 |
| Frosst, P; Hennekens, CH; Horsford, J; Ma, J; Malinow, MR; Rozen, R; Selhub, J; Stampfer, MJ; Willett, WC | 1 |
| Scott, J; Weir, D | 1 |
| Evans, AE; Gey, KF; Harmon, DL; McCrum, EE; McMaster, D; Whitehead, AS; Woodside, JV; Yarnell, JW; Young, IS | 2 |
| Arheart, K; Chaudhary, D; Dennis, V; Green, R; Gupta, A; Jacobsen, DW; Kutner, M; Mayer, EL; Robinson, K; Selhub, J; Vigo, P | 1 |
| Dennis, VW; Robinson, K | 1 |
| Ankri, A; Benzidia, R; Blacher, J; Chadefaux-Vekemans, B; Grosgogeat, Y; Kamoun, P; Montalescot, G; Thomas, D | 1 |
| Blom, HJ; den Heyer, M; Eskes, TK; Mariman, EC; Steegers-Theunissen, RP; Trijbels, FJ; van den Heuvel, LP; van der Put, NM | 1 |
| Jacques, P; Mahnken, B; Selhub, J; Tucker, KL; Wilson, PW | 1 |
| Amendt, K; Diehm, C; Hsu, E; Stammler, F; Stockinger, K | 1 |
| Conley, MR; Mills, JL | 1 |
| Anderson, A; Daskalakis, IG; Lean, ME; Levene, MI; Lucock, MD; Schorah, CJ; Wild, J | 1 |
| Ratashak, SA; Rosenquist, TH; Selhub, J | 1 |
| Mamotte, CD; Taylor, RR; van Bockxmeer, FM; Vasikaran, SD | 1 |
| Rosenberg, IH; Selhub, J; Tucker, KL; Wilson, PW | 1 |
| Allen, WP | 1 |
| Baumgartner, RN; Garry, PJ; Koehler, KM; Pareo-Tubbeh, SL; Romero, LJ | 1 |
| St Clair, L; Swain, RA | 1 |
| Alpert, JE; Borus, JS; Bottiglieri, T; Fava, M; Nierenberg, AA; Rosenbaum, JF | 1 |
| Zidek, W | 1 |
| Deutsch, JC; Kolhouse, JF; Ryder, JW; Santhosh-Kumar, CR | 1 |
| Crooks, R; Dudman, N; Finucane, P; Fryer, J; Guo, XW; Nair, B; Silberberg, J; Wlodarczyk, J; Xie, LJ | 1 |
| Domagała, TB; Gozdecka, H; Krzanowski, M; Libura, M; Szczeklik, A | 1 |
| Bellet, H; Chassé, JF; Cohen, D; Faure-Delanef, L; Guerassimenko, O; Kamoun, P; Lesaulnier, M; Quéré, I; Zittoun, J | 1 |
| Heistad, DD; Lentz, SR; Rios, CD | 1 |
| Futterman, LG; Lemberg, L | 1 |
| Blache, D; Durand, P; Prost, M | 2 |
| Eskes, TK | 6 |
| Freedberg, RS; Hess, DL; Katz, ES; Konecky, N; Kronzon, I; Leung, B; Malinow, MR; Perez, J; Rosenzweig, BP; Tunick, PA; Upson, B | 1 |
| Bottiglieri, T | 2 |
| Andersson, A; Hultberg, B; Lindgren, A | 1 |
| Grobbee, DE; Kok, FJ; Kruyssen, DA; Refsum, H; Schouten, EG; Ueland, PM; Verhoef, P; Witteman, JC | 1 |
| Ahn, C; Aronow, WS; Schoenfeld, MR | 1 |
| Flynn, MA; Herbert, V; Krause, G; Nolph, GB | 1 |
| Chambless, LE; Malinow, MR; Nieto, FJ; Schreiner, PJ; Shimakawa, T; Szklo, M | 1 |
| Matthews, JH | 1 |
| Anderson, PH; Block, PC; Duell, PB; Gluckman, RA; Hess, DL; Holzgang, CR; Kruger, WD; Lin, QR; Malinow, MR; Nieto, FJ; Seltzer, D; Upson, B | 1 |
| Ben-Shlomo, Y; Davey-Smith, G; Harmon, DL; Ramsbottom, D; Whitehead, AS | 1 |
| Dreosti, IE; Fenech, MF; Rinaldi, JR | 1 |
| Chango, A; Nicolas, JP | 1 |
| Baumgartner, RN; Garry, PJ; Koehler, KM; Liang, HC; Pareo-Tubbeh, SL; Romero, LJ | 1 |
| Catalano, PM; Malinow, MR; Rajkovic, A | 1 |
| Beverly, RK; Hess, DL; Koepsell, TD; Longstreth, WT; Malinow, MR; Psaty, BM; Raghunathan, TE; Reitsma, PH; Rosendaal, FR; Schwartz, SM; Siscovick, DS | 1 |
| Blom, HJ; Kluijtmans, LA; Kok, FJ; Kruyssen, DA; Refsum, H; Ueland, PM; Verhoef, P | 1 |
| Eguchi, T; Fujita, N; Nomura, S; Ono, H; Sakamoto, A; Sakura, N; Ueda, H; Ueda, K | 1 |
| Guttormsen, AB; Refsum, H; Svarstad, E; Ueland, PM | 1 |
| Födinger, M; Hörl, WH; Mannhalter, C; Müller, E; Pabinger, I; Schmid, R; Sunder-Plassmann, G; Wölfl, G | 1 |
| Boiocchi, M; Corona, G; Donada, C; Fabris, M; Toffoli, G; Viel, A; Zarrelli, A | 1 |
| Ali, N; Markus, HS; Molloy, J; Powell, J; Sankaralingam, A; Swaminathan, R | 1 |
| Hayoz, D; Monnerat, C | 1 |
| Castro, OL; Houston, PE; Kim, KS; Perlin, E; Rana, S; Sekhsaria, S | 1 |
| Fiskerstrand, T; Refsum, H; Ueland, PM | 1 |
| Refsum, H; Tonstad, S; Ueland, PM | 1 |
| Blom, HJ; De Graaf-Hess, A; Eskes, TK; Mariman, EC; Smeitink, JA; Steegers-Theunissen, RP; Thomas, CM; Trijbels, FJ; van der Put, NM | 1 |
| McNulty, H; McPartlin, J; Scott, JM; Strain, JJ; Ward, M; Weir, DG | 1 |
| Brouwer, IA; de Bree, A; Steegers-Theunissen, RP; van Dusseldorp, M; van het Hof, KH | 1 |
| Bates, CJ; Cole, TJ; Finch, S; Mansoor, MA; Prentice, A; van der Pols, J | 1 |
| Bjerve, KS; Carlsen, SM; Følling, I; Grill, V; Refsum, H; Schneede, J | 1 |
| Bianchi, LA; Bostom, AG; Gohh, RY; Hopkins-Garcia, BJ; Jacques, PF; Nadeau, MR; Rosenberg, IH; Selhub, J; Tsai, MY | 1 |
| Stampfer, MJ | 1 |
| Markle, HV | 1 |
| Ahn, C; Aronow, WS | 3 |
| Drabløs, PA; Hervig, T; Hetland, O; Kristensen, O; Mansoor, MA; Osland, A; Stakkestad, JA; Woie, L | 1 |
| Appert-Flory, A; Bayle, J; Bedoucha, P; Candito, M; Chatel, M; Fisher, F; Jambou, D; Parrot-Roulaud, F; Van Obberghen, E | 1 |
| Cicchetti, G; Marín, GH; Tentoni, J | 1 |
| Arnadottir, M; Hultberg, B | 2 |
| De Santo, NG; Ingrosso, D; Perna, AF | 1 |
| Ali, NS; Markus, HS; Powell, J; Swaminathan, R | 1 |
| Donovan, UM; Gibson, RS; Green, TJ; Houghton, LA; O'Connor, DL; Stephen, AM | 1 |
| Herbert, V | 1 |
| Bostom, AG; Dworkin, L; Jacques, PF; Nadeau, MR; Rosenberg, IH; Selhub, J; Shemin, D; Verhoef, P | 1 |
| Bhopatkar-Teredesai, M; Faraci, FM; Heistad, DD; Lentz, SR; Malinow, MR; Piegors, DJ | 1 |
| Farhadi, D | 1 |
| Beaulieu, AJ; Bostom, AG; Gohh, RY; Hume, AL; Jacques, PF; Nadeau, MR; Rosenberg, IH; Selhub, J | 1 |
| Donovan, U; Gibson, RS; Green, TJ; Houghton, LA; O'Connor, DL | 1 |
| Aakvaag, A; Aanderud, S; Ericsson, UB; Lien, EA; Nedrebø, BG; Nygård, O; Refsum, H; Ueland, PM | 1 |
| Aubard, Y; Baudet, JH; Chinchilla, AM; Piver, P | 1 |
| Peterson, JC; Spence, JD | 1 |
| Bellet, H; Gris, JC; Hoffet, M; Janbon, C; Mares, P; Quere, I | 1 |
| Blom, HJ | 2 |
| Nygård, O; Refsum, H; Ueland, PM; Vollset, SE | 3 |
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| Gustafson, L; Hultberg, B; Nilsson, K | 13 |
| Alagratnam, D; Swaminathan, R; Turner, C; Wickramasinghe, SN; Wierzbicki, AS | 1 |
| Johnson, WG; Scholl, TO | 1 |
| Hozyasz, KK | 1 |
| Donnelly, JG; Isotalo, PA | 1 |
| Abdelmouttaleb, I; Aimone-Gastin, I; Angioi, M; Bennani, N; Danchin, N; Gelot, MA; Guéant, JL; Jeandel, C; Lambert, D; Namour, F | 1 |
| Barnetson, L; Budge, M; Bungay, H; Clarke, R; Esiri, M; Frost, C; Joachim, C; King, E; Molyneux, A; Morris, J; Smith, AD | 1 |
| Arends, GE; Blom, HJ; Eskes, TK; Heil, SG; Nelen, WL; van der Molen, EF; van der Put, NJ | 1 |
| Kaplan, GA; Lakka, TA; Porkkala-Sarataho, E; Rissanen, T; Salonen, JT; Voutilainen, S | 1 |
| Bailey, LB; Cerda, JJ; Herrlinger-Garcia, K; Hutson, AD; Kauwell, GP; Lippert, BL; Rampersaud, GC; Theriaque, DW; Wilsky, CE | 1 |
| Arpesella, G; Branzi, A; Carinci, V; Coccheri, S; Conti, R; Grigioni, F; Leone, O; Magelli, C; Magnani, G; Marinucci, L; Potena, L; Sassi, S; Sorbello, S | 1 |
| Anderson, PH; Block, PC; Duell, PB; Evans, AA; Graf, EE; Hess, DL; Kruger, WD; Malinow, MR; Upson, B; Wang, L | 1 |
| Chisholm, A; Mann, JI; Riddell, LJ; Williams, S | 1 |
| Bagley, P; Bostom, AG; Christopher, K; Dworkin, L; Jacques, PF; Massy, ZA; Selhub, J; Shemin, D; Spiegel, P; Zanabli, A | 1 |
| Lynn, K; McGregor, D; Shand, B | 1 |
| Butterworth, CE; Cornwell, PE; Fox, LM; Heimburger, DC; Sauberlich, HE; Thomson, SW; Turner, ME | 2 |
| Barrera, G; Bunout, D; de la Maza, P; Hirsch, S; Kauffman, R; Petermann, M; Suazo, M | 1 |
| Essama-Tjani, JC; Fuchs, F; Guilland, JC; Potier de Courcy, G; Richard, D | 1 |
| Stehouwer, DA | 1 |
| Allen, RH; Lindenbaum, J; Ogundipe, A; Savage, DG; Stabler, SP | 1 |
| Brattström, L | 1 |
| Bernhard, W; Fuchs, D; Ledochowski, M | 1 |
| Green, T; O'Connor, DL; Picciano, MF | 1 |
| Aviv, A; Bardeguez, A; Jakubowski, H; Zhang, L | 1 |
| Choi, SW; Kim, YI; Mason, JB; Puchyr, M; Shirwadkar, S; Wang, Y | 1 |
| Barbaux, S; Kluijtmans, LA; Whitehead, AS | 1 |
| Cuomo, V; Ingrosso, D; Mancini, FP; Perna, AF; Riccardi, G; Rivellese, AA; Sacco, M; Tufano, A; Vaccaro, O | 1 |
| Bottiglieri, T; Carney, MW; Crellin, R; Laundy, M; Reynolds, EH; Toone, BK | 1 |
| Jennings, R; Madsen, JR; Manning, SM | 1 |
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| Molloy, AM; Scott, JM; Weir, DG | 1 |
| Law, MR; Wald, NJ | 1 |
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| Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J | 4 |
| Barbé, F; Boisson, F; Chango, A; Droesch, S; Fillon-Emery, N; Frémont, S; Lambert, D; Nicolas, JP; Pfister, M; Quilliot, D; Rosenblatt, DS | 1 |
| Bonnardeaux, A; Busque, L; Geadah, D; Leblanc, M; Lebrun, M; Ouimet, D; Tremblay, R | 1 |
| Goodman, MT; Hernandez, B; McDuffie, K; Selhub, J; Wilkens, LR | 1 |
| Alberg, AJ; Comstock, GW; Helzlsouer, KJ; Selhub, J; Shah, KV; Viscidi, RP | 1 |
| Brattström, L; Wilcken, DE | 1 |
| Beresford, SA; Refsum, H; Ueland, PM; Vollset, SE | 1 |
| Booth, GL; Wang, EE | 1 |
| Bjørke-Monsen, AL; Hustad, S; Schneede, J; Ueland, PM; Vollset, SE; Zhang, Y | 1 |
| Klee, GG | 1 |
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| Appel, LJ; Erlinger, T; Jee, SH; Lin, PH; Miller, ER; Nadeau, MR; Selhub, J; Stolzenberg-Solomon, R | 1 |
| Jones, HJ; Landray, MJ; McGlynn, FJ; Thambyrajah, J; Townend, JN; Wheeler, DC | 2 |
| Bagley, PJ; Rosenberg, IH; Selhub, J; Stern, LL | 1 |
| Bassan, H; Fattal-Valevski, A; Gutman, A; Harel, S; Korman, SH; Lerman-Sagie, T | 1 |
| Cortés, F; de la Maza, MP; Hirsch, S | 1 |
| Duell, PB; Graf, EE; Irvin-Jones, A; Malinow, MR; Upson, BM | 1 |
| Aebischer, CP; Beil, A; Bissé, E; Lütschg, J; Minet, JC; Wieland, H | 1 |
| Bailey, J; Coppen, A | 1 |
| Banga, JD; Biesma, DH; Duran, M; Faber, JA; Haas, FJ; Meuwissen, OJ; van der Griend, R | 1 |
| Bandelow, B; Bleich, S; Degner, D; Kornhuber, J; Rüther, E; von Ahsen, N | 1 |
| Borkenstein, M; Erwa, W; Gallistl, S; Mangge, H; Sudi, K | 1 |
| Beloqui, O; Cienfuegos, JA; Herrero, JI; Pardo, F; Prieto, J; Quiroga, J; Sangro, B | 1 |
| Robinson, K; Seshadri, N | 1 |
| Blom, HJ; van der Put, NM | 1 |
| Cummings, PM; Genest, JJ; Giddens, K; Nassar, BA; Title, LM | 1 |
| Chango, A; de Courcy, GP; Emery-Fillon, N; Lambert, D; Nicolas, JP; Pfister, M; Rosenblatt, DS | 1 |
| Dayal, S; Erger, RA; Faraci, FM; Heistad, DD; Lentz, SR; Maeda, N; Malinow, MR | 1 |
| Brouwer, IA | 1 |
| Scott, J | 1 |
| Brodsky, S; Ebin, Z; Goligorsky, MS; Jin, H; Li, H; Zhang, X | 1 |
| Buchmayer, H; Födinger, M; Heinz, G; Hörl, WH; Kletzmayr, J; Papagiannopoulos, M; Rasoul-Rockenschaub, S; Sunder-Plassmann, G | 1 |
| Smulders, YM | 2 |
| Brown, CA; Gravel, RA; Kaufman, JS; McKinney, KQ; Rozen, R | 1 |
| Bailey, LB; Cerda, JJ; Hutson, AD; Kauwell, GP; Rampersaud, GC | 1 |
| Bos, GM; den Heijer, M; Willems, HP | 1 |
| Robinson, K; van Guldener, C | 1 |
| Boers, GH; Naughten, ER; Wilcken, B; Wilcken, DE; Yap, S | 1 |
| Armitage, J; Clarke, R | 1 |
| Ben-Yehuda, A; Friedlander, Y; Friedman, G; Goldschmidt, N; Raz, I; Shpichinetsky, V; Wexler, ID | 1 |
| Cornwell, PE; Lowenthal, EA; Mayo, MS; Thornley-Brown, D | 1 |
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| Graefe, U; Henning, BF; Tepel, M; Zidek, W | 1 |
| Armani, U; Cerone, R; Lorini, R; Minniti, G; Piana, A | 2 |
| Diaz-Arrastia, R | 1 |
| Dubard, MB; Goldenberg, RL; Hogg, BB; Johnston, KE; Tamura, T | 1 |
| Ciani, F; De Leo, V; La Marca, A; Morgante, G; Setacci, C; Zammarchi, E | 1 |
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| Daskalakis, I; Lucock, M | 1 |
| Babinská, K; Béderová, A; Blazícek, P; Kopcová, J; Krajcovicová-Kudlácková, M | 1 |
| Födinger, M; Sunder-Plassmann, G; Winkelmayer, WC | 1 |
| Freeman, DJ; Jordan, J; Kurowska, EM; Piché, LA; Serratore, P; Spence, JD; Wetmore, S | 1 |
| Bülow, I; Knudsen, N; Laurberg, P; Ovesen, L; Perrild, H; Rasmussen, LB | 1 |
| Bie, RB; Bolann, BJ; Grøttum, KA; Loraas, A; Refsum, H; Schjøth, A; Schneede, J; Solli, JD; Stallemo, A; Stokkeland, M; Ueland, PM | 1 |
| Kohlman-Trigoboff, D; Molina, H; Moore, J; Phillips, J; Smith, BM; Stanford, JL | 1 |
| Geadah, D; Leblanc, M; Ouimet, D; Pichette, V | 1 |
| Bang, BK; Bostom, AG; Dwyer, JT; Han, H; Jacques, PF; Kim, YS; Park, JH; Selhub, J | 1 |
| Bratman, S; Harkness, R | 1 |
| Bridge, PJ; Fick, G; Hyndman, ME; Parsons, HG; Warnica, JW | 1 |
| Chambers, JC; Kooner, JS; Obeid, OA; Refsum, H; Ueland, PM; Wrigley, J | 1 |
| Landmark, K; Reikvam, A | 1 |
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| Woodside, JV; Young, IS | 1 |
| Graham, IM; O'Callaghan, P | 2 |
| Boulat, O; Descombes, E; Fellay, G; Perriard, F | 1 |
| Bailey, LB; Boddie, A; Cerda, JJ; Herrlinger-Garcia, K; Hutson, AD; Kauwell, GP; Rampersaud, GC; Theriaque, DW; Wilsky, CE | 1 |
| Clarke, R; Devlin, AM; Fernando, S; Halsted, CH; Ling, EH; Peerson, JM; Smith, AD | 1 |
| Bestetti, A; Biondi, ML; Casari, S; Cugno, M; Guagnellini, E; Maioli, C; Marasini, B; Turri, O; Zeni, S | 1 |
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| Gregory, JF; Jacob, RA; Swendseid, ME | 1 |
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| Bowman, BA; Gunter, EW; Jacques, PF; Johnson, CL; Morris, MS; Rosenberg, IH; Selhub, J; Wright, JD | 1 |
| Blumberg, JB; Dallal, G; McKay, DL; Perrone, G; Rasmussen, H | 1 |
| Abbate, R; Bertoni, E; Brunelli, T; Evangelisti, L; Fedi, S; Gensini, GF; Marcucci, R; Pepe, G; Prisco, D; Rogolino, A; Salvadori, M; Zanazzi, M | 1 |
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| Kok, FJ | 1 |
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| Cho, JW; Huh, W; Kim, B; Kim, DJ; Kim, SJ; Kim, YG; Oh, HY | 1 |
| Bostom, AG; Dworkin, L; Hsu, N; Jacques, PF; Selhub, J; Shemin, D; Yango, A | 1 |
| Bartels, PC; Grooteman, MP; Nubé, MJ; Van Guldener, C; Van Limbeek, J; Van Tellingen, A; Wee, PM | 1 |
| Kurihara, H; Kurihara, Y; Morita, H; Nagai, R; Oh-Hashi, Y; Saito, Y; Shindo, T; Yazaki, Y; Yoshida, S | 1 |
| Dijkhuisen, R; Greaves, M; Meiklejohn, DJ; Vickers, MA | 1 |
| Evans, M; Oudit, GY; Taylor, BV | 1 |
| Blom, HJ; Brouwer, IA; Eskes, TK; Hautvast, JG; Steegers-Theunissen, RP; Thomas, CM; van Dusseldorp, M; van Rooij, IA | 1 |
| Bar-Meir, S; Chowers, Y; Fidder, H; Holland, R; Sela, BA; Simoni, FB | 1 |
| Batista, M; Camera, MI; Janson, J; Kordich, LC; Murúa, AL; Quintana, I | 1 |
| Clarke, R | 2 |
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| Baker, PJ; Banerjee, R; Brody, LC; Garrett, L; Harris, M; Liu, ML; Shane, B; Stitzel, M; Swanson, DA; Wu, J | 1 |
| Abdelmouttaleb, I; Adjalla, C; Debard, R; Guéant, J; Namour, F; Olivier, J; Salvat, C | 1 |
| Kluijtmans, LA; Whitehead, AS | 1 |
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| Stam, F; Stehouwer, CD; van Guldener, C | 1 |
| Bieglmayer, C; Födiger, M; Hörl, WH; Ignatescu, MC; Kletzmayr, J; Sunder-Plassmann, G | 1 |
| Ames, BN; Jacob, RA; Johnston, KE; Mayr, CA; Tamura, T; Wallock, LM | 1 |
| Chambless, LE; Howard, VJ; Malinow, MR; Pettigrew, LC; Spence, JD; Stampfer, M; Toole, JF | 1 |
| Barbé, F; Boisson, F; Chango, A; Christidès, JP; Galan, P; Guilland, JC; Hercberg, S; Nicolas, JP; Perrin, MO; Pfister, M; Potier De Courcy, G; Rabhi, K | 1 |
| Beilby, J; Rossi, E | 1 |
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| Blom, HJ; Diekman, MJ; Tijssen, JG; van der Put, NM; Wiersinga, WM | 1 |
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| Böger, RH; Sydow, K | 1 |
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| Refsum, H; Ueland, PM; Vollset, SE | 1 |
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| Hollman, PC; Katan, MB; Olthof, MR; Zock, PL | 1 |
| Bostom, AG; Jacques, PF; Rich, S; Rosenberg, IH; Selhub, J; Wilson, PW | 1 |
| Allen, RH; Baumgartner, RN; Garry, PJ; Koehler, KM; Rimm, EB; Stabler, SP | 1 |
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| Arning, E; Bottiglieri, T; Cardaioli, G; Caso, V; Gallai, V; Paciaroni, M; Parnetti, L | 1 |
| Hetyési, K; Hídvégi, T; Jermendy, G | 1 |
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| Barrera Saldaña, H; García Cavazos, R; Garza Elizondo, M; López Valdez, R; Martínez de Villarreal, LE; Perales Dávila, J; Rojas Martínez, A; Saldívar Rodríguez, D; Triana Saldaña, H; Valdez Leal, R; Zacarías Villarreal Pérez, J | 1 |
| McKinley, MC; McNulty, H; McPartlin, J; Pentieva, K; Scott, JM; Strain, JJ; Ward, M; Weir, DG | 1 |
| Apsner, R; Bieglmayer, C; Buchmayer, H; Födinger, M; Hagen, W; Hauser, AC; Hörl, WH; Ignatescu, M; Köller, E; Papagiannopoulos, M; Rehak, PH; Sunder-Plassmann, G | 1 |
| Eichholzer, M; Gutzwiller, F; Lüthy, J; Stähelin, HB | 1 |
| Artuch, R; Cardo, E; Colomé, C; Farré, C; Monrós, E; Pineda, M; Valls, C; Vilaseca, MA | 1 |
| Billett, HH; Estrada, DA | 1 |
| Albanes, D; Barrett, MJ; Hartman, TJ; Selhub, J; Stolzenberg-Solomon, R; Virtamo, J; Woodson, K | 1 |
| Casani, A; Cristofani, R; Fattori, B; Nacci, A; Sagripanti, A | 1 |
| Bellet, H; Gris, JC; Janbon, C; Marès, P; Mercier, E; Quéré, I | 1 |
| Locatelli, S; Lüftjohann, D; Schmidt, HH; Sigit, JI; von Bergmann, K | 1 |
| Bosselmann, KP; Dierkes, J; Domröse, U; Luley, C; Neumann, KH | 1 |
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| Barbé, F; Chango, A; Frémont, S; Gérard, P; Guéant, JL; Klein, M; Nicolas, JP; Weryha, G | 1 |
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| Axenti, I; Brzostek, T; Czachór, R; Dropiński, J; Jankowski, M; Musiał, J; Sanak, M; Szczeklik, A; Tendera, M; Twardowska, M | 1 |
| O'Leary, K; Sheehy, PJ | 2 |
| Bostom, AG; Jacques, PF; Liaugaudas, G; Rosenberg, IH; Selhub, J | 1 |
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| Blom, HJ; Trijbels, FJ; van der Put, NM; van Straaten, HW | 1 |
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| Chambers, ST; Dellow, WJ; George, PM; Lever, M; McGregor, DO; Robson, RA | 1 |
| Castaldo, P; Cimmino, A; De Santo, NG; di Carlo, E; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Blom, HJ; de Bree, A; Kromhout, D; Verschuren, WM | 1 |
| El-Khairy, L; Graham, IM; Refsum, H; Ueland, PM; Vollset, SE | 1 |
| Baghurst, P; Couper, J; Thomas, DW; Wiltshire, E | 1 |
| Arning, E; Bottiglieri, T; Dayal, S; Faraci, FM; Heistad, DD; Lentz, SR; Maeda, N; Malinow, MR; Sigmund, CD | 1 |
| Ambrosch, A; Boeing, H; Dierkes, J; Jeckel, A; Luley, C; Westphal, S | 1 |
| Delongchamp, RR; Poirier, LA; Sinha, R; Wise, CK | 1 |
| Fawaz, K; Kim, YI; Knox, T; Lee, YM; Libby, E; Mason, JB; Norton, R | 1 |
| Friso, S; Jacques, PF; Rosenberg, IH; Selhub, J; Wilson, PW | 1 |
| Dixon, JB; Dixon, ME; O'Brien, PE | 2 |
| Johnston, KE; Nagy, TR; Secor, SM; Tamura, T | 1 |
| Evensen, ET; Hoff, G; Lien, EA; Majak, BM; Ueland, PM; Ulvik, A; Vollset, SE | 1 |
| Erb, N; Kitas, GD | 1 |
| Graefe, U; Henning, BF; Riezler, R; Tepel, M; Zidek, W | 1 |
| Buchmayer, H; Födinger, M; Heinz, G; Hörl, WH; Kletzmayr, J; Papagiannopoulos, M; Perschl, A; Sunder-Plassmann, G; Vychytil, A | 1 |
| Barbara, JA; McDonald, SP; Tallis, GA; Whiting, MJ | 1 |
| Blom, HJ; de Bree , A; Kromhout, D; Verschuren, WM | 1 |
| Hansen, M; Jensen, M; Madsen, LT; Samman, S; Sandström, B; Sørensen, SS | 1 |
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| Boehm, BO; Fuchs, D; Grammer, TB; März, W; Schroecksnadel, K | 1 |
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| Beiser, A; Bookman, E; Chen, F; Chen, WM; Doheny, KF; Gogarten, SM; Hsu, FC; Jacques, P; Keene, KL; Liu, X; Nelson, S; Sale, MM; Selhub, J; Seshadri, S; Wang, L; Weinstein, G; Williams, SR; Wolf, PA; Worrall, BB; Yang, Q; Zilka, M | 1 |
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| Belarbi, S; Bendini, M; Chelouti, H; Djerdjouri, B; El Hadi Cherifi, M; Kacimi, G; Khelil, M; Nazef, K; Tazir, M | 1 |
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| Brouwer-Brolsma, EM; de Groot, LC; de Jonge, R; Dhonukshe-Rutten, RA; Enneman, AW; Ham, AC; Lips, P; Oliai Araghi, S; Sohl, E; Stricker, BH; Swart, KM; Uitterlinden, AG; van der Cammen, TJ; van der Velde, N; van der Zwaluw, NL; van Dijk, SC; van Meurs, JB; van Schoor, NM; van Wijngaarden, JP; Witkamp, RF; Zillikens, MC | 1 |
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| Kalita, J; Misra, UK; Singh, VK | 1 |
| Parhofer, KG | 1 |
| Attanasio, M; Cirillo, M; Coccia, ME; Fatini, C | 1 |
| de Almeida, AG; Finsterer, J; Rodrigues, AM; Scorza, CA; Scorza, FA | 1 |
| Jin, YT; Lin, PY; Wu, YC; Wu, YH; Yang, JH | 1 |
| Cuoghi, C; Marcacci, M; Pietrangelo, A; Ricci, A; Ventura, P | 1 |
| Bao, Y; Gu, YH; Guo, J; Matsuura, M; Qiu, Z; Ushijima, M; Wang, F; Xie, X; Zhang, Q; Zhang, T; Zheng, P | 1 |
| Boyarchuk, O; Kovalchuk, T | 1 |
| Guo, N; Liu, X; Tian, D; Zhang, C; Zhang, J; Zhao, Y; Zhu, R | 1 |
| Chen, C; Guo, Y; Ma, Y | 1 |
| Cao, Y; Chai, J; Ji, D; Liu, H; Liu, J; Luo, C; Wang, W; Wu, J; Wu, Y; Xue, K; Yan, W; Zhu, X | 1 |
| Pieczyńska, J; Płaczkowska, S; Skórska, K; Sozański, R; Sołtysik, M | 1 |
| Chandyo, RK; Hysing, M; Kvestad, I; McCann, A; Ranjitkar, S; Schwinger, C; Sharma, S; Shrestha, LP; Shrestha, M; Strand, TA; Ueland, PM; Ulak, M | 1 |
| de Rijke, YB; Felix, JF; Gaillard, R; Heil, SG; Jaddoe, VWV; Monasso, GS | 1 |
| Cheng, M; Fu, C; Li, X; Shi, Y; Wang, Y; Xue, H; Yan, Q; Zhu, D | 1 |
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| Chen, C; Fang, M; Guo, L; Lu, R; Ma, X; Tong, Y; Wang, Y; Xie, S; Zheng, H | 1 |
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| Cirillo, M; Coccia, ME; Fatini, C; Fucci, R; Rubini, S | 1 |
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| Chen, Y; Du, Y; Duan, H; Fu, J; Huang, G; Huang, L; Li, W; Li, Z; Liu, H; Liu, Q; Ma, F; Sun, C; Wang, G; Wang, Z; Zhang, X; Zhao, J; Zhou, D; Zhu, Y | 1 |
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| Kasyanov, ED; Kostina, OV; Mazo, GE; Piatoikina, AS; Rukavishnikov, GV; Semennov, IV; Verbitskaya, EV; Zhilyaeva, TV | 1 |
| Abdul Ghani, SAB; Arul, K; Bee, GGB; Cheah, CC; Chow, PKH; Cook, SA; Lim, TR; Pei, HJ; Sandireddy, R; Shekeran, SG; Singh, BK; Singh, MK; Sinha, RA; Suzuki, A; Tikno, K; Tripathi, M; Wang, J; Widjaja, A; Wong, KA; Xiao, RP; Yen, PM; Zhang, X; Zhou, J | 1 |
| Düzkalır, HG; Kaya Özçora, GD; Özcabı, B; Söbü, E | 1 |
| Abraham, VJ; Aronraj, J; Barney, AM; Cherian, AG; Christudass, CS; Danda, S; Jayaprakash, L; Marcus, TA | 1 |
| Chung, BY; Chung, EH; Eun, YS; Heo, NH; Kim, HO; Kim, JE; Kim, JY; Lee, SH; Lee, SY; Park, CW; Park, YL; Shin, MJ; Yang, NG | 1 |
| Bommarito, P; Clark, J; Fry, RC; Gamble, MV; García-Vargas, GG; Rubio-Andrade, M; Stýblo, M | 1 |
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| Dai, Y; Wang, D; Zhang, X; Zou, R | 1 |
| Balwani, M; Fanelli, MJ; Gouya, L; Longo, N; Petrides, PE; Phillips, J; Plutzky, J; Rhyee, S; Sardh, E; Sweetser, MT; Ventura, P | 1 |
| Chen, W; Li, J; Ma, L; Yuan, Y; Zhao, J | 1 |
| An, X; Deng, Y; Fan, R; Li, J; Li, Z; Liao, J; Wang, Y; Xia, Y; Yang, X | 1 |
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| Burton, GJ; Capatina, N; Yung, HW | 1 |
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| Jia, J; Li, T; Quan, M; Song, Y | 1 |
| Fishchuk, L; Gorovenko, N; Rossokha, Z; Yeroshkina, K | 1 |
| Gaskins, AJ; Thornburgh, S | 1 |
| Adarmes-Gómez, AD; Bonilla-Toribio, M; Buiza-Rueda, D; Gómez-Garre, P; Jesús, S; Jimenez-Jaraba, MV; Macías-García, D; Martín-Rodríguez, JF; Mir, P; Muñoz-Delgado, L; Periñán, MT | 1 |
| Guéant, JL; Guéant-Rodriguez, RM; Oussalah, A; Rosenberg, I; Zuily, S | 1 |
| Chen, J; Dan, L; Larsson, SC; Li, X; Sun, Y; Xie, Y; Yuan, S | 1 |
| Beltrán, LJ; Bulleid, NJ; Johnstone, IL; Page, AP; Tjahjono, E; Winter, AD | 1 |
| Bhatta, RS; Bisen, AC; Godbole, MM; Kumar, M; Kumar, P; Mishra, A; Rathore, AS; Sanap, SN; Verma, SK | 1 |
| Guo, QN; Liao, SX; Liu, ZY; Long, JG; Wang, HD; Wang, L | 1 |
| Agarwal, R; Agrawal, T; Dewan, P; Gomber, S; Kotru, M; Sharma, S | 1 |
| Arthurs, AL; Jankovic-Karasoulos, T; Roberts, CT; Smith, MD; Williamson, JM | 1 |
| Huang, X; Liu, D; Wu, M | 1 |
| Gambello, MJ; Gonzalez, A; Kožich, V; Li, H; Smith, GH; Sokolová, J | 1 |
| Bodunova, NA; Dudina, GA; Kagramanova, AV; Knyazev, OV; Li, IA; Lishchinskaya, AA; Noskova, KK; Parfenov, AI; Sabelnikova, EA | 1 |
| de Lourdes Samaniego-Vaesken, M; Marco Mendez, R; Montero-Bravo, AM; Morais-Moreno, C; Partearroyo, T; Puga, AM; Ruperto, M; Varela-Moreiras, G; Vicente-Arche, Á | 1 |
| Jakubowski, H; Perła-Kaján, J; Sikora, M; Skrzydlewski, P | 1 |
| Abraham, MK; Anju, SM; Aswathy, AO; George, S; Ibrahim Shkhair, A; Lekha, GM; Lekshmi, RS; Syamchand, SS; Varghese, S | 1 |
| Amorim, PMS; Andreoni, S; Bonilha, AC; D Almeida, V; Demarzo, M; Guerra-Shinohara, EM; Liu, ASLW; Mapurunga, M; Moscardi, AVS; Neves, FJ; Pinto, J; Ramos, LR; Tomita, LY | 1 |
| Bilo, L; Bosso, G; De Luca, M; Oliviero, U; Pirone, D; Striano, P; Trinchillo, A; Valvano, A | 1 |
| Abdulhalim, EN; El-Bassyouni, HT; Hamed, K; Hashem, SA; Kamel, SM; Khedr, AA; Youness, ER | 1 |
| Cameron-Smith, D; Fraser, K; Gillies, NA; Han, SM; Milan, AM; Roy, NC; Sharma, P; Teh, R | 1 |
| Akbulut, S | 1 |
| Kaur, J; Mahajan, A; Sapehia, D; Srinivasan, R | 1 |
| Mazokopakis, EE; Papadakis, JA; Papadomanolaki, MG | 4 |
| Deo, P; Dhillon, VS; Fenech, M; Thomas, P | 1 |
| Chen, S; Fang, AP; He, TT; Huang, BX; Huang, RZ; Huang, ZH; Li, SY; Liu, XZ; Liu, ZY; Lu, XT; Luo, Y; Maierhaba, W; Mo, QW; Wang, YF; Wang, YN; Yang, MT; Zhang, XG; Zhu, HL | 1 |
| Alatas, İO; Atalay, E; Demir, SS; Ozalp, O; Sozer, O; Yildirim, N | 1 |
| Park, HY; Song, BM; Song, S | 1 |
| Celermajer, DS; Chook, P; Guo, DS; Kwok, CYT; Lin, CQ; Poon, YKP; Woo, KS; Yin, YH | 1 |
| Bennett, D; Campbell, H; Duthie, S; Eguiagaray, IM; Li, X; Little, J; MacFarlane, AJ; McNulty, H; Momoli, F; Montazeri, A; Munger, R; Rubini, M; Senekal, M; Theodoratou, E; Wang, L | 1 |
| Chen, WJ; Hsueh, YM; Huang, CY; Huang, YL; Lee, HL; Lin, YC; Pu, YS; Shiue, HS | 1 |
| Hou, HM; Qin, XJ; Zhao, HY | 1 |
| Bhandari, N; Chowdhury, R; Kvestad, I; Manapurath, R; Strand, TA; Taneja, S; Yajnik, CS | 1 |
| Darabi, M; Hoseinlar, SF; Laghousi, D; Nikanfar, M; Nourazarian, A; Shademan, B | 1 |
| Costigliolo, F; Esposito, P; Garibotto, G; Picciotto, D; Saio, M; Sofia, A; Valli, A; Verzola, D; Viazzi, F | 1 |
| Mallhi, AK; Twum, F; Zhang, J | 1 |
| Cao, S; Chen, L; Dong, Z; Ren, N; Wu, C; Yan, X | 1 |
| Chen, L; Hong, H; Leng, H; Li, W; Song, C; Yang, Z; Zhong, Y | 1 |
| Babu, GR; Deepa, R; Mandal, S; Van Schayck, OCP | 1 |
| Shi, B; Zhang, M; Zhao, M | 1 |
| Cikim, G; Hatipoglu, HS; Susam, S | 1 |
| Chandratheva, A; Chen, J; Coughlan, CH; Goodison, W; Murphy, E; Rees, A | 1 |
| Chen, G; Chen, X; Feng, Y; Liu, Y; Luo, J; Yang, Y | 1 |
| Huang, W; Wen, C; Xu, R; Yu, X | 1 |
| Chen, GL; Li, L; Liu, H; Lv, L; Ma, Z; Tong, X | 1 |
| Cui, W; Fang, F; Han, X; Liu, Y | 1 |
| Gao, L; Guo, Y; Liu, L; Liu, Y; Ma, X; Wang, X; Wang, Y; Xu, J; Yuan, L; Zhou, S | 1 |
| Noori, SH; Shawkat Ahmed, H | 1 |
| Abd El Hady, NMS; El-Hawwary, AM; Mahmoud, AA; Rizk, MS; Saleh, NY | 1 |
| Bao, H; Chen, G; Cheng, X; Cheng, Z; Cui, Y; Ding, C; Hu, L; Huang, X; Huo, Y; Li, P; Qin, X; Sheng, C; Song, D; Tang, G; Wang, J; Wang, X; Wang, Z; Yao, C; Zhang, J | 1 |
| Fukuoka, H; Horiguchi, S; Kagawa, Y; Kawabata, T; Kubo, Y; Nishikawa, M; Shoji, K; Tajima, A | 1 |
| Choi, R; Chun, G; Lee, EH; Lee, SG; Park, W | 1 |
| Mangoni, AA; Zinellu, A | 1 |
| Ogawa, S; Ota, K; Takahashi, T; Yoshida, H | 1 |
| Cheng, X; Long, L; Peng, H; Shen, L; Wang, X; Xia, C; Yang, C; Yang, Y; Zhou, Y | 1 |
| Gou, M; Guo, X; Liu, Y | 1 |
| Feng, W; Gao, H; Lu, Y; Pan, D; Smith, JD; Song, G; Su, M; Sun, G; Sun, J; Wang, S; Wang, X; Wang, Y; Xu, D; Yan, Q | 1 |
| Al-Kassab-Córdova, A; Alarcon-Braga, EA; Benites-Zapata, VA; Cabrera-Guzmán, JC; Hernandez-Bustamante, EA; Herrera-Añazco, P; Ulloque-Badaracco, JR | 1 |
| Al-Khlaiwi, T; Almushawah, A; Alsomali, A; Habib, SA; Habib, SS | 1 |
| Clément, A; Clément, P; Menezo, YJR; Viot, G | 1 |
| Gu, J; Lei, C; Zhang, M | 1 |
| Chung, HW; Hsu, YH; Tu, MC; Wu, WC; Yang, JJ | 1 |
| Horiguchi, S; Kawabata, T; Kubo, Y; Shoji, K; Tajima, A | 1 |
475 review(s) available for homocysteine and folic acid
| Article | Year |
|---|---|
Methyl biogenesis.
Topics: Folic Acid; Homocysteine; Humans; Leucovorin; Mental Disorders; Methionine; Methionine Adenosyltransferase; Methylation; S-Adenosylmethionine; Tetrahydrofolates | 1978 |
Folic acid metabolism in vitamin B12 deficiency.
Topics: Animals; Biological Transport; Folic Acid; Folic Acid Deficiency; Glutamates; Homocysteine; Humans; Liver; Methionine; Methyltransferases; Peptide Biosynthesis; Rats; Sheep; Tetrahydrofolates; Vitamin B 12 Deficiency | 1975 |
The effects of vitamins B12, B6, and folate on blood homocysteine levels.
Topics: Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Pyridoxine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1992 |
Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment.
Topics: Adult; Arterial Occlusive Diseases; Cerebral Arterial Diseases; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Hydro-Lyases; Male; Middle Aged; Pyridoxine; Time Factors | 1990 |
Homocysteine, folic acid, and the prevention of vascular disease.
Topics: Arterial Occlusive Diseases; Arteriosclerosis; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Metabolism, Inborn Errors; Vascular Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1989 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Disease Models, Animal; Dogs; Estrogens; Folic Acid; Homocysteine; Kynurenine; Methionine; Mice; Neurotransmitter Agents; Prostaglandins; Pyridoxal Phosphate; Quinolinic Acid; Quinolinic Acids; Rats; Seizures; Spinal Cord | 1986 |
[Hereditary anomalies of methionine metabolism in children].
Topics: Age Factors; Child; Flatfoot; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Intellectual Disability; Kyphosis; Marfan Syndrome; Metabolism, Inborn Errors; Methionine; Scoliosis | 1972 |
Regulation of dihydrofolate reductase and other folate-requiring enzymes.
Topics: Alcohol Oxidoreductases; Animals; Enzyme Induction; Erythrocytes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Guinea Pigs; Homocysteine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia; Leukocytes; Ligases; Methotrexate; Oxidoreductases; Rats; Salmonella typhimurium; Serine; Streptococcus; Tetrahydrofolate Dehydrogenase | 1968 |
Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization.
Topics: Amino Acids; Anemia, Macrocytic; Contraceptives, Oral; Diet; DNA; Ethanol; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Glycine; Homocysteine; Humans; Malabsorption Syndromes; Methionine; Pharmacology; Serine; Toxins, Biological; Vitamin B 12 | 1970 |
Roles of vitamin B 12 and folic acid in methionine synthesis.
Topics: Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Methyltransferases; S-Adenosylmethionine; Transferases; Vitamin B 12 | 1970 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deoxyuridine; Erythrocytes, Abnormal; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Homocysteine; Humans; Hypothyroidism; Lymphocyte Activation; Methionine; Pregnancy; Pregnancy Complications; Statistics as Topic; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
Hyperhomocysteinemia as a risk factor for cardiovascular disease in patients undergoing hemodialysis.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Renal Dialysis; Risk Factors | 1995 |
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.
Topics: Arteriosclerosis; Coronary Disease; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Pyridoxine; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 1995 |
Hyperhomocysteinaemia: a role in the accelerated atherogenesis of chronic renal failure?
Topics: Adult; Age Factors; Arteriosclerosis; Cystathionine beta-Synthase; Cysteine; Female; Folic Acid; Heterozygote; Homocysteine; Homocystinuria; Humans; Kidney Failure, Chronic; Male; Methionine; Methylation; Middle Aged; Renal Dialysis; Sex Factors | 1995 |
Vitamin nutrition status and homocysteine: an atherogenic risk factor.
Topics: Arteriosclerosis; Case-Control Studies; Coronary Disease; Folic Acid; Homocysteine; Humans; Nutritional Status; Pyridoxine; Risk Factors; Vitamin B 12 | 1994 |
Hyperhomocysteinaemia: a newly recognized risk factor for vascular disease.
Topics: Arteriosclerosis; Betaine; Coronary Disease; Folic Acid; Heterozygote; Homocysteine; Homocystinuria; Homozygote; Humans; Methionine; Pyridoxine; Risk Factors; Vascular Diseases | 1994 |
Update of new risk factors and prevention of neural-tube defects.
Topics: Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Neural Tube Defects; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 1993 |
Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid.
Topics: Arteriosclerosis; Coronary Disease; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Neural Tube Defects; Nutritional Physiological Phenomena; Polymorphism, Genetic; Risk Factors; Sex Characteristics | 1996 |
Homocysteine and vascular disease.
Topics: Arteriosclerosis; Diet; Folic Acid; Homocysteine; Humans; Pyridoxine; Risk Factors | 1996 |
More folic acid for everyone, now.
Topics: Adult; Aged; Anencephaly; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Infant, Newborn; Male; Pregnancy; Risk Factors; Spinal Dysraphism; United States; Vitamin B 12; Vitamin B 12 Deficiency | 1996 |
Homocysteine and neural tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Infant, Newborn; Mice; Neural Tube Defects; Pregnancy; Randomized Controlled Trials as Topic; Rats; Vitamin B 12 | 1996 |
Homocysteine and coronary atherosclerosis.
Topics: Coronary Artery Disease; Folic Acid; Homocysteine; Homocystinuria; Humans; Pyridoxine; Risk Factors; Vitamin B 12 | 1996 |
Molecular genetic aspects of hyperhomocysteinemia and its relation to folic acid.
Topics: Amino Acid Sequence; Base Sequence; DNA, Complementary; Folic Acid; Homocysteine; Humans; Molecular Sequence Data; Mutation; Oxidoreductases Acting on CH-NH Group Donors | 1996 |
Homocysteinemia and vascular disease in end-stage renal disease.
Topics: Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Male; Methionine; Middle Aged; Pyridoxine; Thrombosis; Vitamin B 12 | 1996 |
Folic acid to prevent neural tube defects: scientific advances and public health issues.
Topics: Diet; Female; Folic Acid; Genetic Testing; Hematinics; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Prenatal Care; Risk Factors | 1996 |
Folic acid in the prevention of birth defects.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Methionine; Neural Tube Defects; Preconception Care; Pregnancy; Prenatal Care | 1996 |
Folate nutrition and older adults: challenges and opportunities.
Topics: Aged; Aged, 80 and over; Aging; Female; Folic Acid; Food, Fortified; Homocysteine; Homocystinuria; Humans; Male; Nutritional Status; Risk Factors; Vascular Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
The role of folic acid in deficiency states and prevention of disease.
Topics: Anemia, Macrocytic; Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Nutritional Physiological Phenomena; Pregnancy | 1997 |
Atherosclerotic vascular disease: will folate or gene therapy be useful?
Topics: Animals; Arteriosclerosis; Carotid Arteries; Female; Folic Acid; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Homocysteine; Humans; Male | 1997 |
Folates and the fetus.
Topics: Anemia, Megaloblastic; Carbon; Fetus; Folic Acid; Gestational Age; Homocysteine; Humans; Neural Tube Defects; Recurrence | 1997 |
Folate, vitamin B12, and neuropsychiatric disorders.
Topics: Depressive Disorder; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylation; Multiple Sclerosis; Vitamin B 12; Vitamin B 12 Deficiency | 1996 |
[Homocysteine and venous thromboembolism].
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Female; Folic Acid; Genetic Carrier Screening; Homocysteine; Humans; Male; Middle Aged; Risk; Thromboembolism; Thrombophlebitis | 1997 |
Folate intake in Europe: recommended, actual and desired intake.
Topics: Adult; Europe; Female; Folic Acid; Food; Homocysteine; Humans; Male; Neural Tube Defects; Nutrition Policy; Pregnancy; Risk Factors | 1997 |
Adverse effects of hyperhomocysteinemia and their management by folic acid.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Methylation; Risk Factors; Uremia | 1997 |
[Folates and the neural tube. Review of the literature].
Topics: Animals; Europe; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Methionine; Methylation; Neural Crest; Neural Tube Defects; Preconception Care; Pregnancy; Prenatal Care; Prevalence; Risk Factors | 1997 |
Folate and coronary heart disease.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Coronary Disease; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutrition Policy; Oxidoreductases; Polymorphism, Genetic; Risk Factors | 1998 |
Homocysteine and cardiovascular disease.
Topics: Arteriosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Female; Folic Acid; Folic Acid Deficiency; Forecasting; Homocysteine; Humans; Intracranial Arteriosclerosis; Male; Peripheral Vascular Diseases; Prevalence; Risk Factors; Safety; Thromboembolism; Vitamin B 12; Vitamin B 12 Deficiency | 1998 |
Homocysteine and atherothrombosis.
Topics: Amino Acid Metabolism, Inborn Errors; Arteriosclerosis; Cardiovascular Diseases; Deficiency Diseases; Folic Acid; Homocysteine; Homocystine; Humans; Thrombosis; Vitamin B Complex | 1998 |
Prevention of neural tube defects: vitamins, enzymes and genes.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Inositol; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Neurologic Mutants; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Vitamins | 1998 |
The implications of genetic diversity for nutrient requirements: the case of folate.
Topics: Animals; Folic Acid; Genetic Variation; Homocysteine; Humans; Metabolism, Inborn Errors; Molecular Structure; Nutritional Requirements; Phenotype | 1998 |
Hyperhomocysteinemia as a cause of vascular occlusion in end-stage-renal disease.
Topics: Cardiovascular Diseases; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Hematinics; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Pyridoxine; Renal Dialysis; Vitamin B 12 | 1998 |
Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Folic Acid; Food, Formulated; Hematinics; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Pyridoxine; Randomized Controlled Trials as Topic; Vitamin B 12 | 1998 |
Genetic defects of folate and cobalamin metabolism.
Topics: Absorption; Amino Acid Metabolism, Inborn Errors; Animals; Coenzymes; Fibroblasts; Folic Acid; Homocysteine; Humans; Lysosomes; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Tetrahydrofolates; Transcobalamins; Vitamin B 12 | 1998 |
Remethylation defects: guidelines for clinical diagnosis and treatment.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Betaine; Child, Preschool; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Infant; Infant, Newborn; Metabolism, Inborn Errors; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Oxidoreductases Acting on CH-NH Group Donors; Practice Guidelines as Topic; Vitamin B 12 | 1998 |
Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders.
Topics: Central Nervous System Diseases; Citrates; Demyelinating Diseases; Folic Acid; Homocysteine; Humans; Mental Disorders; Methionine; Methylmalonic Acid; Vitamin B 12 | 1998 |
Vitamins B12, B6 and folate as determinants of homocysteine concentration in the healthy population.
Topics: Folic Acid; Food, Fortified; Homocysteine; Humans; Nutritional Status; Pyridoxine; Vitamin B 12 | 1998 |
Neural tube defects, vitamins and homocysteine.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Rats; Spinal Dysraphism | 1998 |
Homocysteine, lipoprotein(a) and fibrinogen: metabolic risk factors for cardiovascular complications of chronic renal disease.
Topics: Arteriosclerosis; Cardiovascular Diseases; Chronic Disease; Fibrinogen; Folic Acid; Homocysteine; Humans; Kidney Diseases; Lipoprotein(a); Risk Factors | 1998 |
From birth to conception. Open or closed.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Netherlands; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Spinal Dysraphism | 1998 |
The role of homocysteine, folate and other B-vitamins in the development of atherosclerosis.
Topics: Arteriosclerosis; Coronary Disease; Folic Acid; Hematinics; Homocysteine; Humans; Middle Aged; Pyridoxine; Risk Factors; Vitamin B 12; Vitamin B Complex | 1997 |
[Increased p-homocysteine--a risk factor for thrombosis].
Topics: Adult; Age Factors; Aged; Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Risk Factors; Sex Factors; Thrombosis | 1998 |
Individual variability in homocysteine response to folate depletion: an unusual case.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Genetic Variation; Genotype; Homocysteine; Humans; Iron Deficiencies; Male; Nutritional Requirements; Postmenopause | 1998 |
Open or closed? A world of difference: a history of homocysteine research.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Metabolism, Inborn Errors; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Vascular Diseases | 1998 |
MTHFR association with arteriosclerotic vascular disease?
Topics: Alleles; Arteriosclerosis; Databases, Bibliographic; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; MEDLINE; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation | 1998 |
Folate deficiencies and cardiovascular pathologies.
Topics: Cardiovascular Diseases; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Molecular Structure | 1998 |
[Homocysteine as a nonlipid factor in the pathogenesis of atherosclerosis].
Topics: Aged; Animals; Arteriosclerosis; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Renal Dialysis; Risk Factors | 1998 |
Prevention of stroke.
Topics: Anticholesteremic Agents; Anticoagulants; Atrial Fibrillation; Carotid Stenosis; Cerebrovascular Disorders; Cholesterol, LDL; Exercise; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Hypertension; Patient Selection; Smoking Cessation | 1998 |
Should all elderly people receive folate supplements?
Topics: Aged; Aging; Coronary Disease; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Neoplasms; Nutritional Requirements; Nutritional Status | 1998 |
Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry.
Topics: Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Vitamin B 12 Deficiency | 1998 |
Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease.
Topics: Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Pyridoxine; Randomized Controlled Trials as Topic; Research Design; Vitamin B 12 | 1998 |
B vitamins and homocysteine in cardiovascular disease and aging.
Topics: Aging; Cardiovascular Diseases; Diet; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Humans; Pyridoxine; Risk Factors; Vitamin B 12; Vitamin B Deficiency | 1998 |
Cobalamin deficiency in patients infected with the human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Erythrocytes; Folic Acid; Homocysteine; Humans; Malabsorption Syndromes; Nervous System Diseases; Prognosis; Vitamin B 12 Deficiency | 1999 |
Hyperhomocysteinemia, atherosclerosis and thrombosis.
Topics: Adult; Aged; Animals; Arteriosclerosis; Avitaminosis; Case-Control Studies; Clinical Trials as Topic; Cohort Studies; Cross-Sectional Studies; Cystathionine beta-Synthase; Female; Folic Acid; Gene Frequency; Homocysteine; Homocystinuria; Hormone Replacement Therapy; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Muscle, Smooth, Vascular; Oxidoreductases Acting on CH-NH Group Donors; Prevalence; Primates; Prospective Studies; Pyridoxine; Risk Factors; Smoking; Tamoxifen; Thrombophilia; Thrombosis; Vitamin B 12 | 1999 |
Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement.
Topics: Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Neural Tube Defects; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors; Vascular Diseases | 1999 |
[Hyperhomocysteinemia as a risk factor for venous thrombosis].
Topics: Adult; Aged; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prospective Studies; Pyridoxine; Randomized Controlled Trials as Topic; Venous Thrombosis; Vitamin B 12 | 1999 |
[Folic acid protects against neural tube defects. But how many women of reproductive age have been informed about this fact?].
Topics: Female; Folic Acid; Guidelines as Topic; Health Education; Homocysteine; Humans; Multicenter Studies as Topic; Neural Tube Defects; Nutritional Requirements; Pregnancy; Primary Prevention | 1999 |
Homocysteine and vascular disease.
Topics: Arteriosclerosis; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic; Risk Factors; Thrombosis; Vitamins | 1999 |
Future for folates in cardiovascular disease.
Topics: Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Vasodilation | 1999 |
[Hyperhomocysteinemia: a risk factor for arterial and venous thrombosis].
Topics: Arteriosclerosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Pyridoxine; Risk Factors; Thromboembolism; Vitamin B 12 | 1999 |
Homocyst(e)ine, atherosclerosis, and thrombosis.
Topics: Adult; Aged; Arteriosclerosis; Female; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Hyperhomocysteinemia; Male; Middle Aged; Thrombosis | 1999 |
Folate and oral clefts: where do we go from here? New directions in oral clefts research.
Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Variation; Homocysteine; Humans; Infant, Newborn; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Pregnancy | 1999 |
[Hyperhomocysteinemia, a risk factor for atherosclerosis: causes and effects].
Topics: Age Factors; Arterial Occlusive Diseases; Arteriosclerosis; Cerebrovascular Disorders; Coronary Disease; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipid Metabolism; Lipoproteins; Male; Meta-Analysis as Topic; Methionine; Middle Aged; Peripheral Vascular Diseases; Prospective Studies; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors | 1999 |
What is homocysteine?
Topics: Dietary Supplements; Folic Acid; Heart Diseases; Homocysteine; Humans; Pyridoxine; Risk Factors; Vitamin B 12 | 1999 |
Homocysteine and atherosclerosis.
Topics: Arteriosclerosis; Ethnicity; Folic Acid; Homocysteine; Humans; Minority Groups; Risk Factors | 1999 |
Plasma homocysteine as a cardiovascular risk factor: causal, consequential, or of no consequence?
Topics: Aged; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Incidence; Male; Meta-Analysis as Topic; Prospective Studies; Pyridoxine; Retrospective Studies; Risk; Risk Factors; Smoking; Vitamin B 12 | 1999 |
Homocysteine and endothelial dysfunction: a link with cardiovascular disease.
Topics: Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Methionine; Reactive Oxygen Species | 2000 |
Hyperhomocysteinemia in organ transplantation.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Organ Transplantation; Polymorphism, Genetic; Pyridoxine; Risk Factors; Vitamin B 12 | 2000 |
Folic acid: influence on the outcome of pregnancy.
Topics: Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Pregnancy; Pregnancy Outcome | 2000 |
Clinical relevance of hyperhomocysteinaemia in atherothrombotic disease.
Topics: Arteriosclerosis; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Thrombosis | 2000 |
Maternal folate status and lactation.
Topics: Animals; Animals, Suckling; Arteriosclerosis; Disease Susceptibility; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant; Infant, Newborn; Iron Deficiencies; Lactation; Mammals; Milk; Neoplasms; Neural Tube Defects; Neutrophils; Nutritional Requirements; Pregnancy; Pregnancy Complications; Pteroylpolyglutamic Acids; Rats | 1997 |
Pathophysiology, prevention, and potential treatment of neural tube defects.
Topics: Animals; Disease Models, Animal; Embryonic and Fetal Development; Folic Acid; Homocysteine; Humans; Incidence; Nervous System; Neural Tube Defects; Preventive Medicine | 2000 |
Homocysteine, folate enzymes and neural tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Pregnancy Complications; Vitamin B 12 | 1999 |
Homocysteine and ischaemic heart disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Cohort Studies; Comorbidity; Cystathionine beta-Synthase; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Ischemia; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Retrospective Studies | 1999 |
Homocysteine and cardiovascular disease: cause or effect?
Topics: Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Kidney; Kidney Diseases | 2000 |
The controversy over homocysteine and cardiovascular risk.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Kidney Diseases; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Prospective Studies; Risk Factors; Vitamin B Complex | 2000 |
Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care.
Topics: Aged; Arteriosclerosis; Canada; Coronary Disease; Dietary Supplements; Disease Susceptibility; Fasting; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine; Preventive Medicine; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12 | 2000 |
Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate.
Topics: Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Hyperhomocysteinemia and thrombosis.
Topics: Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Male; Pregnancy; Risk Factors; Thrombosis | 2000 |
[The importance of folic acid in current medicine].
Topics: Adult; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Homocysteine; Humans; Infant; Infant, Newborn; Neural Tube Defects; Pregnancy | 2000 |
Homocysteine and coronary risk.
Topics: Age Factors; Clinical Trials as Topic; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male; Risk Factors; Sex Factors | 1999 |
Neural tube defects and a disturbed folate dependent homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic | 2000 |
Homocysteine and cardiovascular disease: dietary supplements for all.
Topics: Cardiovascular Diseases; Congenital Abnormalities; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Nutritional Status; Pregnancy; Risk Factors | 2000 |
Genetic modulation of homocysteinemia.
Topics: Amino Acid Substitution; Cardiovascular Diseases; Cystathionine beta-Synthase; Cysteine; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Mutation, Missense; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Sulfur; Tetrahydrofolates | 2000 |
Homocysteine and renal disease.
Topics: Adult; Arteriosclerosis; Cardiovascular Diseases; Case-Control Studies; Child; Endothelium, Vascular; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Life Tables; Male; Methionine; Peritoneal Dialysis; Prospective Studies; Pyridoxine; Renal Dialysis; Survival Analysis; Thrombophilia; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2000 |
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.
Topics: Adolescent; Adult; Aged; Australia; Child; Child, Preschool; Cohort Studies; Cystine; Drug Resistance; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Infant; Ireland; Male; Methionine; Middle Aged; Netherlands; Pyridoxine; Risk; Risk Factors; Thrombophilia; Vascular Diseases; Vitamin B 12 | 2000 |
Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements.
Topics: Adult; Aged; Cardiovascular Diseases; Clinical Trials as Topic; Diet; Double-Blind Method; Drug Synergism; Europe; Female; Folic Acid; Forecasting; Genetic Variation; Homocysteine; Humans; Hyperhomocysteinemia; Male; Meta-Analysis as Topic; Middle Aged; Multicenter Studies as Topic; North America; Prospective Studies; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Treatment Outcome; Vitamin B 12 | 2000 |
Homocysteine and neurologic disease.
Topics: Brain Diseases; Epilepsy; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Neurodegenerative Diseases; Pyridoxine; Vascular Diseases; Vitamin B 12 | 2000 |
New perspectives on folate status: a differential role for the vitamin in cardiovascular disease, birth defects and other conditions.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects | 2000 |
Therapeutic potential of total homocysteine-lowering drugs on cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kidney Transplantation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Renal Dialysis; Risk Factors; Vitamin B 12 | 2000 |
[Nutrition, dietary supplementation and coronary heart disease].
Topics: Coronary Disease; Dietary Fats; Dietary Supplements; Feeding Behavior; Female; Fish Oils; Folic Acid; Homocysteine; Humans; Lipoproteins; Male; Nutritional Physiological Phenomena; Nuts; Phytosterols; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12 | 2000 |
Folate and homocysteine.
Topics: Blood Vessels; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Polymorphism, Genetic; Risk Factors; Vitamin B Complex | 2000 |
The role of folic acid in the prevention of cardiovascular disease.
Topics: Cardiovascular Diseases; Coronary Disease; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Models, Biological; Risk | 2000 |
Folic acid, vitamins B6 and B12: relation to homocysteine and cardiovascular disease.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Pyridoxine; Risk Factors; Vitamin B 12 | 2001 |
Folic acid and neural tube defects.
Topics: Biological Availability; Diet; Dose-Response Relationship, Drug; England; Female; Flour; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Myocardial Ischemia; Neural Tube Defects; Nutritive Value; Pregnancy; Pregnancy Complications; Prevalence; Risk Factors; Wales | 2001 |
Rationale for risk reduction of cardiovascular disease using homocysteine concentration in blood and plasma as biomarker: support by clinical data.
Topics: Biomarkers; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Nutrition Policy; Pyridoxine; Risk Factors; Vitamin B 12 | 2001 |
Homocysteine, vitamins, and coronary artery disease. Comprehensive review of the literature.
Topics: Clinical Trials as Topic; Coronary Disease; Diet; Folic Acid; Homocysteine; Humans; Pyridoxine; Risk Factors; Vitamin B 12 | 2000 |
The folate cycle and disease in humans.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aminohydrolases; Biological Transport, Active; Folic Acid; Formate-Tetrahydrofolate Ligase; Histidine; Homeostasis; Homocysteine; Humans; Intestinal Mucosa; Kidney Diseases; Metabolism, Inborn Errors; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Oxidoreductases; Polyglutamic Acid; Purine Nucleotides; Serine; Tetrahydrofolates | 2001 |
Homocysteine metabolism in renal failure.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases | 2001 |
Number 58: homocysteine and disease.
Topics: Alzheimer Disease; Animals; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet; Folic Acid; Homocysteine; Humans; Neural Tube Defects | 2000 |
Homocysteine: a new cardiac risk factor?
Topics: Coronary Artery Disease; Coronary Disease; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Models, Biological; Risk Factors | 2001 |
[Homocysteine, endothelial dysfunction and cardiovascular risk: pathomechanisms and therapeutic options].
Topics: Adult; Aged; Cardiovascular Diseases; Clinical Trials as Topic; Drug Therapy, Combination; Endothelium, Vascular; Female; Fibrinolysis; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Time Factors; Vitamin B Complex | 2001 |
[Homocysteine and cardiovascular risk].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Arteriosclerosis; Clinical Trials as Topic; Coronary Artery Disease; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Models, Biological; Vitamin B 12 | 2001 |
The role of folate, antioxidant vitamins and other constituents in fruit and vegetables in the prevention of cardiovascular disease: the epidemiological evidence.
Topics: Antioxidants; Ascorbic Acid; Cardiovascular Diseases; Clinical Trials as Topic; Epidemiologic Studies; Folic Acid; Fruit; Homocysteine; Humans; Vegetables; Vitamin E | 2001 |
Homocysteine and arteriosclerosis: established risk factor or new illusion?
Topics: Arteriosclerosis; Cognition; Folic Acid; Homocysteine; Humans | 2000 |
Genes, folate and homocysteine in embryonic development.
Topics: Animals; Dietary Supplements; Embryonic and Fetal Development; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2001 |
Current approaches to therapy for vascular injury.
Topics: Anti-Bacterial Agents; Arteriosclerosis; Bacterial Infections; Coronary Restenosis; Folic Acid; Homocysteine; Humans; Macrolides | 2001 |
Impaired homocysteine metabolism and atherothrombotic disease.
Topics: Age Factors; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Models, Chemical; Risk Factors; S-Adenosylmethionine; Sex Factors | 2001 |
Folate, homocysteine and neural tube defects: an overview.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Intestinal Absorption; Methylenetetrahydrofolate Reductase (NADPH2); Models, Chemical; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Prevalence | 2001 |
[From gene to disease; from homocysteine to hyperhomocysteinemia].
Topics: Cystathionine beta-Synthase; Folic Acid; Heterozygote; Homocysteine; Homocystinuria; Homozygote; Humans; Hyperhomocysteinemia; Methionine; Mutation; Risk Factors; Vascular Diseases | 2001 |
Homocysteine, folic acid, B vitamins and cardiovascular risk.
Topics: Animals; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Risk Factors; Vitamin B Complex | 2001 |
Does lowering plasma homocysteine reduce vascular disease risk?
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Pyridoxine; Risk Factors; Vascular Diseases | 2001 |
[Homocysteine--a risk factor for atherosclerosis].
Topics: Antioxidants; Arteriosclerosis; Disease Progression; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Oxidative Stress; Risk Factors; Thrombosis; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2001 |
Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome.
Topics: Congenital Abnormalities; Deficiency Diseases; Developing Countries; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Importance of folate in human nutrition.
Topics: Biological Availability; Birth Weight; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; India; Intestinal Absorption; Liver; Male; Meat; Neoplasms; Neural Tube Defects; Nutrition Policy; Nutritional Physiological Phenomena; Pregnancy; Prevalence; Public Health; Vegetables | 2001 |
Nutrition and cognitive impairment in the elderly.
Topics: Aged; Aging; Alzheimer Disease; Antioxidants; Avitaminosis; Dementia; Dementia, Vascular; Dietary Supplements; Educational Status; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hypertension; Life Style; Nutritional Physiological Phenomena; Nutritional Status; Risk Factors; Stroke; Vitamin B 12 Deficiency | 2001 |
Homocysteine, folate, and cardiovascular disease.
Topics: Antioxidants; Cardiovascular Diseases; Europe; Folic Acid; Fruit; Homocysteine; Humans; Hyperhomocysteinemia; Primary Prevention; Risk Factors; Vegetables | 2001 |
Homocysteine, vascular dementia and Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dementia, Vascular; Double-Blind Method; Folic Acid; Homocysteine; Humans; Middle Aged; Placebos; Risk Factors; Time Factors; Vitamin B 12; Vitamin B 6 | 2001 |
Prevention of pathologies associated with oxidative stress and dietary intake deficiencies: folate deficiency and requirements.
Topics: Animals; Diet; DNA; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lipid Peroxidation; Neoplasms; Nutritional Status; Oxidative Stress; Tetrahydrofolate Dehydrogenase; Uracil | 2001 |
Folates and prevention of disease.
Topics: Cardiovascular Diseases; Colorectal Neoplasms; Dietary Supplements; Folic Acid; Food, Fortified; Homocysteine; Humans; Mental Disorders; Neural Tube Defects; Treatment Outcome | 2001 |
Folic acid: are current fortification levels adequate?
Topics: Biomarkers; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy; Safety; Treatment Outcome; United States | 2001 |
Folate, homocysteine, endothelial function and cardiovascular disease. What is the link?
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Endothelium, Vascular; Folic Acid; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Nitric Oxide; Oxidoreductases Acting on CH-NH Group Donors; Vitamins | 2001 |
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
Beneficial role for folate in the prevention of colorectal and breast cancer.
Topics: Breast Neoplasms; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Homocysteine; Humans; Methylation; Prospective Studies; Risk Factors | 2001 |
Cardiovascular risk in the Asia-Pacific region from a nutrition and metabolic point of view: vitamin deficiencies.
Topics: Aged; Antioxidants; Asia; Avitaminosis; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Pacific Islands; Risk Factors; Vitamin B 12; Vitamin B 6 | 2001 |
Therapy of hyperhomocysteinemia in end-stage renal disease patients.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Renal Replacement Therapy; Vitamin B 12; Vitamin B 6 | 2001 |
Assessment of homocysteine as a cardiovascular risk factor in clinical practice.
Topics: Biomarkers; Blood Chemical Analysis; Cardiovascular Diseases; Clinical Trials as Topic; Diet; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Mutation; Risk Factors; Vitamin B 12 | 2001 |
Current progress in early pregnancy investigation.
Topics: Abortion, Habitual; Abortion, Spontaneous; Chorionic Gonadotropin; Corpus Luteum; Factor V; Female; Fertilization in Vitro; Fibrinolytic Agents; Folic Acid; Glutathione S-Transferase pi; Glutathione Transferase; Homocysteine; Humans; Isoenzymes; Luteinizing Hormone; Nausea; Placentation; Platelet Aggregation; Point Mutation; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Sperm Injections, Intracytoplasmic; Vomiting | 2001 |
Folates and cardiovascular disease.
Topics: Arteriosclerosis; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NAD+); Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Oxidoreductases | 2002 |
Emergent cardiovascular risk factor: homocysteine.
Topics: Blood Chemical Analysis; Cardiovascular Diseases; Folic Acid; Health Education; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 6 | 2002 |
Folate bioavailability and health.
Topics: Biological Availability; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Food, Fortified; Hematinics; Homocysteine; Humans; Intestinal Absorption; Mental Disorders; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy | 2002 |
Homocysteine.
Topics: Arteriosclerosis; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Metabolic Diseases | 2002 |
Plasma homocysteine: a new risk factor for Alzheimer's disease?
Topics: Alzheimer Disease; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2002 |
Is folate a promising agent in the prevention and treatment of cardiovascular disease in patients with renal failure?
Topics: Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Hematinics; Homocysteine; Humans; Kidney Failure, Chronic | 2002 |
Homocysteine, B vitamins, and cognitive deficit in the elderly.
Topics: Aging; Cognition Disorders; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2002 |
Hyperhomocysteinemia, pteridines and oxidative stress.
Topics: Animals; Folic Acid; Homocysteine; Humans; Immunity; Oxidative Stress; Pteridines; Risk Factors; Vascular Diseases | 2002 |
Hyperhomocyst(e)inemia as a risk factor after renal transplantation.
Topics: Cardiovascular Diseases; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Risk Factors | 2001 |
Folic acid and homocysteine in age-related disease.
Topics: Aged; Aging; Cardiovascular Diseases; Congenital Abnormalities; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Mental Disorders; Neoplasms; Neurodegenerative Diseases; Stroke | 2002 |
Folic acid intake and its effects on the prevention of neural tube defects, the masking of vitamin B12 deficiency and the reduction of homocysteine.
Topics: Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects; Oklahoma; Pregnancy; Prenatal Care; Primary Prevention; Risk Assessment; United States; United States Food and Drug Administration; Vitamin B 12 Deficiency | 2002 |
Homocysteine and occlusive arterial disease.
Topics: Arteriosclerosis; Diet; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Vitamin B 12 | 2002 |
Folic acid and prevention of birth defects.
Topics: Absorption; Adult; Congenital Abnormalities; Dietary Supplements; Drug Interactions; Female; Folic Acid; Hematinics; Homocysteine; Humans; Infant, Newborn; Nutritional Physiological Phenomena; Preconception Care; Pregnancy; Risk Factors | 2002 |
Homocyst(e)ine and coronary heart disease: pharmacoeconomic support for interventions to lower hyperhomocyst(e)inaemia.
Topics: Coronary Disease; Dietary Supplements; Economics, Pharmaceutical; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Vitamin B 12; Vitamin B 6 | 2002 |
Folic acid fortification, folate status and plasma homocysteine.
Topics: Cohort Studies; Folic Acid; Homocysteine; Humans; Neural Tube Defects | 2002 |
Lowering plasma homocysteine with folic acid in cardiovascular disease: what will the trials tell us?
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Prognosis; Sensitivity and Specificity; Treatment Outcome | 2002 |
In vivo stable isotope measurements of methyl metabolism: applications in pathophysiology and interventions.
Topics: Deuterium Oxide; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infusions, Intravenous; Kidney Failure, Chronic; Methionine; Methylation; Serine; Tomography, Emission-Computed; Tritium | 2002 |
Is there a relationship between risk factors for oral clefts?
Topics: Birth Order; Cleft Lip; Cleft Palate; Confounding Factors, Epidemiologic; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Maternal-Fetal Exchange; Odds Ratio; Pregnancy; Risk Factors; Smoking; Socioeconomic Factors | 2002 |
Pharmacotherapy of hyperhomocysteinaemia in patients with thrombophilia.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Pyridoxine; Renal Insufficiency; Thrombophilia; Vitamin B 12; Vitamins | 2002 |
Hyperhomocysteinemia and transplant coronary artery disease.
Topics: Animals; Coronary Disease; Folic Acid; Heart Transplantation; Homocysteine; Humans; Hyperhomocysteinemia; Pyridoxine | 2002 |
Effect of food fortification on folic acid intake in the United States.
Topics: Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Linear Models; Male; Neural Tube Defects; Nutritional Status; United States; United States Food and Drug Administration | 2003 |
Pemetrexed safety and dosing strategy.
Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Homocysteine; Humans; Methylmalonic Acid; Neoplasms; Pemetrexed; Thymidylate Synthase; Vitamin B 12 | 2002 |
Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders.
Topics: Aging; Alzheimer Disease; Animals; Apoptosis; Cell Death; Depressive Disorder; Folic Acid; Homocysteine; Humans; Mental Disorders; Methylation; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Parkinson Disease; Schizophrenia; Stroke | 2003 |
The methionine-homocysteine cycle and its effects on cognitive diseases.
Topics: Alzheimer Disease; Cardiovascular Diseases; Cognition Disorders; Dementia, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Memory Disorders; Methionine; Methionine Adenosyltransferase; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2003 |
Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism.
Topics: Biomarkers; Carbon; Diet; DNA Methylation; Folic Acid; Homocysteine; Humans; Methylation; Nutritional Status; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B Complex | 2003 |
Homocysteine and Alzheimer's disease.
Topics: Age Factors; Aged; Alzheimer Disease; Apolipoproteins E; Brain; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Nutrition Policy; Risk Factors; Sex Factors; United States; Vitamin B 12; Vitamin B 6 | 2003 |
Reducing coronary artery disease by decreasing homocysteine levels.
Topics: Coronary Disease; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Nurse's Role; Patient Education as Topic; Primary Prevention; Risk Factors; Vitamin B 12; Vitamin B 6 | 2003 |
Homocysteine, folic acid and B-group vitamins in obstetrics and gynaecology.
Topics: Abortion, Spontaneous; Congenital Abnormalities; Contraceptives, Oral, Hormonal; Female; Fetal Death; Fetal Growth Retardation; Folic Acid; Gynecology; Homocysteine; Humans; Menopause; Neural Tube Defects; Obstetrics; Pre-Eclampsia; Pregnancy; Uterine Cervical Dysplasia; Vitamin B Complex | 2003 |
[Cellular and molecular mechanism of cardiovascular disease resulting from hyperhomocysteinemia].
Topics: Animals; Arteriosclerosis; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Rats | 2002 |
Vitamins, homocysteine and cardiovascular risk.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamins | 2002 |
News and views on folate and elderly persons.
Topics: Aged; Cardiovascular Diseases; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Mental Disorders; Methylation; Neoplasms; Risk Factors; Vitamin B 12 Deficiency | 2003 |
Methylation and acetylation in nervous system development and neurodegenerative disorders.
Topics: Acetylation; Animals; Diet; DNA; DNA Damage; DNA Methylation; Embryonic and Fetal Development; Folic Acid; Homocysteine; Humans; Nervous System; Neurodegenerative Diseases | 2003 |
Cervical dysplasia: early intervention.
Topics: Antioxidants; Carotenoids; Diet; Female; Folic Acid; Homocysteine; Humans; Indoles; Papillomaviridae; Risk Factors; Uterine Cervical Dysplasia; Viral Vaccines; Vitamin A | 2003 |
Homocysteine and atherothrombosis: diagnosis and treatment.
Topics: Arteriosclerosis; Coronary Disease; Endothelium, Vascular; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Oxidative Stress; Polymorphism, Genetic; Thrombosis | 2003 |
Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence.
Topics: Adolescent; Child; Child, Preschool; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Infant; Infant, Newborn; Methylmalonic Acid; Vitamin B 12 Deficiency | 2003 |
Total plasma homocysteine and restenosis after percutaneous coronary angioplasty: current evidence.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Coronary Restenosis; Folic Acid; Homocysteine; Humans; Risk Assessment; Risk Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2003 |
[Homocysteine and coronary artery disease].
Topics: Coronary Artery Disease; Dietary Supplements; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors | 2003 |
Folate and homocysteine metabolism: therapeutic targets in cardiovascular and neurodegenerative disorders.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Models, Biological; Molecular Structure; Neurodegenerative Diseases | 2003 |
[BIOSYNTHESIS OF METHYL GROUP OF METHIONINE].
Topics: Alkylation; Amino Acids; Cysteine; Folic Acid; Homocysteine; Metabolism; Methionine; Research; Vitamin B 12 | 1964 |
Changes in haemostasis during normal pregnancy: does homocysteine play a role in maintaining homeostasis?
Topics: Female; Folic Acid; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Neural Tube Defects; Placenta Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Hematologic; Thromboembolism | 2003 |
[Optimal use of markers for cobalamin/folate status. Results from a survey in a group of psychogeriatric patients].
Topics: Aged; Biomarkers; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Mental Disorders; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Homocysteine and essential hypertension.
Topics: Antioxidants; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Muscle, Smooth, Vascular; Nitric Oxide; Vitamin B 12 | 2003 |
[Homocysteine as a coronary risk factor].
Topics: Alcoholic Beverages; Arteriosclerosis; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Disease; Diet; Female; Folic Acid; Glycine max; Homocysteine; Humans; Hyperhomocysteinemia; Male; Platelet Aggregation; Risk Factors; Vitamin B 12; Vitamin B 6 | 2003 |
[Public health control of hyperhomocysteinemia and its consequences].
Topics: Alzheimer Disease; Canada; Cardiovascular Diseases; Flour; Folic Acid; Food, Fortified; Hematinics; Homocysteine; Humans; Hungary; Hyperhomocysteinemia; Neoplasms; Neural Tube Defects; Primary Prevention; Public Health; Randomized Controlled Trials as Topic; United Kingdom; United States; Vitamin B Complex; Vitamin B Deficiency | 2003 |
Update on cobalamin, folate, and homocysteine.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Metabolism, Inborn Errors; Polymorphism, Genetic; Vascular Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease.
Topics: Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Retinal Artery Occlusion; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2003 |
DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations.
Topics: Austria; Cardiovascular Diseases; Female; Folic Acid; Germany; Homocysteine; Humans; Hyperhomocysteinemia; Male; Risk Factors; Switzerland; Thrombosis; Vitamin B 12; Vitamin B 6 | 2003 |
Does homocysteine cause hypertension?
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Metabolic Syndrome; Pyridoxine | 2003 |
Interactions of homocysteine, nitric oxide, folate and radicals in the progressively damaged endothelium.
Topics: Endothelium, Vascular; Folic Acid; Free Radicals; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Vascular Diseases | 2003 |
Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Down Syndrome; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Transcobalamins; Vitamin B 12 | 2003 |
Clinical inquiries. Is folate supplementation indicated for patients with CAD?
Topics: Coronary Artery Disease; Folic Acid; Hematinics; Homocysteine; Humans; Randomized Controlled Trials as Topic | 2004 |
Patients with atherosclerotic vascular disease: how low should plasma homocyst(e)ine levels go?
Topics: Arteriosclerosis; Clinical Trials as Topic; Dipeptides; Folic Acid; Homocysteine; Homocystine; Humans; Pyridoxine; Risk Factors; Vitamin B 12 | 2001 |
Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications.
Topics: Abortion, Spontaneous; Animals; Embryonic Development; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Transcobalamins; Vitamin B 12 | 2004 |
Folate, homocysteine, endothelial function and cardiovascular disease.
Topics: Antioxidants; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Risk Factors; Vitamin B Complex | 2004 |
Homocysteine and post-angioplasty restenosis.
Topics: Angioplasty, Balloon, Coronary; Coronary Restenosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Postoperative Complications; Risk Factors | 2003 |
[The role of folic acid and homocysteine in the pathogenesis of ischaemic heart disease].
Topics: Folic Acid; Homocysteine; Humans; Multicenter Studies as Topic; Myocardial Ischemia | 2004 |
[Homocysteine and neuropsychiatric disorders].
Topics: Alzheimer Disease; Dementia, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mental Disorders; Parkinson Disease; Risk Factors; Stroke; Vitamin B 12; Vitamin B 6 | 2004 |
Evidence for a protective (synergistic?) effect of B-vitamins and omega-3 fatty acids on cardiovascular diseases.
Topics: Cardiovascular Diseases; Dietary Supplements; Drug Synergism; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12; Vitamin B 6 | 2004 |
Folate and homocysteine interrelationships including genetics of the relevant enzymes.
Topics: Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NAD+) | 2004 |
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors | 2004 |
Treatment of coronary heart disease with folic acid: is there a future?
Topics: Coronary Disease; Endothelium, Vascular; Folic Acid; Hematinics; Homocysteine; Humans; Inflammation | 2004 |
A critical evaluation of the relationship between serum vitamin B, folate and total homocysteine with cognitive impairment in the elderly.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cognition Disorders; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2004 |
Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases.
Topics: Cardiovascular Diseases; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Patient Care Management; Practice Guidelines as Topic; Thrombosis; Vitamin B Complex | 2004 |
Consequences of elevated homocysteine during embryonic development and possible modes of action.
Topics: Embryonic and Fetal Development; Folic Acid; Homocysteine; Humans; Models, Anatomic; Models, Biological | 2004 |
Folic acid: neurochemistry, metabolism and relationship to depression.
Topics: Brain; Depressive Disorder; Dietary Supplements; Folic Acid; Homocysteine; Humans | 2004 |
Vitamin B12 and folate depletion in cognition: a review.
Topics: Cognition; Cognition Disorders; Dementia; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
[Hyperhomocysteinemia: from theory and practice in the treatment of thrombophilias].
Topics: Administration, Oral; Anticoagulants; Blood Coagulation Tests; Cardiovascular Diseases; Double-Blind Method; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Marfan Syndrome; Multicenter Studies as Topic; Mutation; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Risk Factors; Thrombophilia; Time Factors; Venous Thrombosis; Vitamin B 12; Vitamin B 6 | 2004 |
Homocysteine: is it a clinically important cardiovascular risk factor?
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Myocardial Infarction; Reference Values; Risk Factors; Vitamin B Complex | 2004 |
Menopause, the cardiovascular risk factor homocysteine, and the effects of treatment.
Topics: Cardiovascular Diseases; Estrogen Replacement Therapy; Female; Folic Acid; Homocysteine; Humans; Menopause; Risk Factors; Vitamin B 12; Vitamin B 6 | 2004 |
"New" cardiovascular risk factors in patients with chronic kidney disease: role of folic acid treatment.
Topics: C-Reactive Protein; Cardiovascular Diseases; Chronic Disease; Folic Acid; Homocysteine; Humans; Kidney Diseases; Lipid Peroxidation; Risk Factors | 2005 |
Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle.
Topics: Avitaminosis; Cardiovascular Diseases; Creatinine; Folic Acid; Homocysteine; Humans; Incidence; Kidney Diseases; Life Style; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Physiological Phenomena; Polymorphism, Genetic; Pyridoxal; Riboflavin; Vitamin B 12 | 2004 |
[Methylenetetrahydrofolate polymorphism, folic acid, homocysteine associated with neural tube defects].
Topics: Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic | 2004 |
Nutritional importance of choline for brain development.
Topics: Animals; Apoptosis; Brain; Cell Division; Cell Movement; Cell Proliferation; Choline; Female; Folic Acid; Gene Expression Regulation, Developmental; Homocysteine; Humans; Male; Memory; Neurons; Pregnancy | 2004 |
Treatment of depression: time to consider folic acid and vitamin B12.
Topics: Brain; Depressive Disorder, Major; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Mapping the theories of preeclampsia: the role of homocysteine.
Topics: Adult; Age Factors; Biomarkers; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Maternal Age; Parity; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Primary Prevention; Randomized Controlled Trials as Topic; Risk Assessment; Sensitivity and Specificity; Survival Rate; Vitamin B 12 | 2005 |
Effects of betaine intake on plasma homocysteine concentrations and consequences for health.
Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Folic Acid; Homocysteine; Humans; Lipids | 2005 |
[Group B vitamins as new variables related to the cardiovascular risk].
Topics: Adult; Aged; Arteriosclerosis; Cardiovascular Diseases; Case-Control Studies; Clinical Trials as Topic; Cross-Over Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Primary Prevention; Prospective Studies; Retrospective Studies; Risk; Risk Factors; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2005 |
Metabolism of homocysteine and its relationship with cardiovascular disease.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia | 2004 |
The impact of metabolism on DNA methylation.
Topics: Alzheimer Disease; Animals; Arteriosclerosis; DNA Methylation; Folic Acid; Gene Expression Regulation; Glycine N-Methyltransferase; Homocysteine; Humans; Methionine; Methyltransferases; Models, Biological; S-Adenosylmethionine | 2005 |
[Determination and utilisation of the plasmatic concentration of homocysteine in clinical practice].
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12 | 2005 |
Health implications of homocysteine and folates: possible preventive measures.
Topics: Aging; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Preventive Medicine; Risk Factors; Sex Characteristics | 2005 |
The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence.
Topics: Carotenoids; Cell Transformation, Neoplastic; Cysteine; Diet; Female; Folic Acid; Homocysteine; Humans; Methionine; Nutritional Physiological Phenomena; Uterine Cervical Neoplasms; Vitamins | 2005 |
Water-soluble vitamins: research update.
Topics: Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Neural Tube Defects; Niacinamide; Nutritional Requirements; Pregnancy; Riboflavin; Riboflavin Deficiency; Solubility; Thiamine; Thiamine Deficiency; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency; Vitamin B Complex; Vitamin B Deficiency | 2005 |
Folate metabolism and cardiovascular disease.
Topics: Biomarkers; Cardiovascular Diseases; DNA; Folic Acid; Homocysteine; Humans; Methylation; Risk Factors | 2005 |
Homocysteine and endothelial function in human studies.
Topics: Blood Flow Velocity; Endothelium, Vascular; Folic Acid; Hematinics; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Vascular Diseases; Vasodilation | 2005 |
Homocysteine and folic acid: implications for pregnancy.
Topics: Canada; Female; Folic Acid; Food, Fortified; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; International Cooperation; National Health Programs; Neural Tube Defects; Pre-Eclampsia; Pregnancy; United States | 2005 |
The significance of folic acid for epilepsy patients.
Topics: Anticonvulsants; Epilepsy; Female; Folic Acid; History, 20th Century; Homocysteine; Humans; Male; Methionine; Models, Biological; Neural Tube Defects; Pregnancy; Vascular Diseases | 2005 |
Homocysteine and folate metabolism in depression.
Topics: Animals; Depression; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylation; Models, Biological; Neurotransmitter Agents; Vitamin B 12 Deficiency | 2005 |
Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; DNA; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Mutation | 2006 |
Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Pregnancy; Pregnancy Outcome; Vitamin B 12 | 2005 |
Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dietary Supplements; Dose-Response Relationship, Drug; Drug Synergism; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Sex Factors; Vitamin B 12; Vitamin B 6 | 2005 |
Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?
Topics: Case-Control Studies; Coronary Stenosis; Folic Acid; Genotype; Global Health; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Polymorphism, Genetic; Prospective Studies; Residence Characteristics | 2005 |
Homocysteine-lowering treatment in coronary heart disease.
Topics: Adult; Aged; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prognosis; Vitamins | 2005 |
[Homocysteine--risk factor or risk indicator?].
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Child; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Infarction; Pregnancy; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Vitamin B Complex | 2005 |
Disruption of methyl group metabolism by ethanol.
Topics: Animals; Central Nervous System Depressants; Ethanol; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Liver; Methionine; Rats; Swine; Swine, Miniature | 2005 |
Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Homocystinuria; Humans; Kidney Diseases; Myocardial Infarction; Randomized Controlled Trials as Topic; Stroke; Vitamin B Complex | 2006 |
The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?
Topics: Animals; Canada; Carrier Proteins; Cytosol; Dietary Supplements; Disease Progression; DNA, Neoplasm; Folate Receptor 1; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Homocysteine; Humans; Mutation; Neoplasms; Prognosis; Receptors, Cell Surface; Transcription Factors; Tumor Cells, Cultured; United States | 2006 |
[Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].
Topics: Adult; Animals; Antioxidants; Cells, Cultured; Clinical Trials as Topic; Endothelial Cells; Fatty Liver; Female; Folic Acid; Hepatitis; Homocysteine; Humans; Insulin Resistance; Male; Metabolic Syndrome; Oxidative Stress; Rats; Risk Factors; Silybin; Silymarin; Time Factors; Vitamin B 12; Vitamin D; Vitamins | 2006 |
Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Biological Transport; Bone Marrow; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Myelin Sheath; Nerve Tissue; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Genetic variation in genes of folate metabolism and neural-tube defect risk.
Topics: Adult; Female; Folic Acid; Genetic Variation; Homocysteine; Humans; Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Risk Factors | 2006 |
Folate and human reproduction.
Topics: Diet; Dietary Supplements; Female; Fetal Development; Fetus; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Lactation; Male; Neural Tube Defects; Nutritional Requirements; Placenta; Pregnancy; Pregnancy Complications; Reproduction | 2006 |
Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet.
Topics: Amino Acids, Sulfur; Animals; Choline; Diet; DNA Methylation; Drug Interactions; Endocrine System; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Methionine; Methylation; Nutritional Requirements; Pregnancy; Proteins; S-Adenosylmethionine | 2006 |
The many facets of hyperhomocysteinemia: studies from the Framingham cohorts.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cardiovascular Diseases; Carotid Stenosis; Cohort Studies; Dementia; Diet; Female; Folic Acid; Fractures, Bone; Heart Failure; Homocysteine; Humans; Hyperhomocysteinemia; Male; Massachusetts; Middle Aged; Risk Factors; Stroke; Vascular Diseases; Vitamin B 12; Vitamin B 6 | 2006 |
Vitamins and minerals 4: overview of folate and the B vitamins.
Topics: Alzheimer Disease; Cardiovascular Diseases; Chemoprevention; Dementia, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Neoplasms; Primary Prevention; Risk Factors; Risk Reduction Behavior; Vitamin B 12; Vitamin B 6 | 2006 |
Homocysteine lowering with folic acid and vitamin B supplements: effects on cardiovascular disease in older adults.
Topics: Adult; Aging; Animals; Cardiovascular Diseases; Clinical Trials as Topic; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B Complex; Vitamin B Deficiency | 2006 |
Neural tube defects and folate: case far from closed.
Topics: Animals; Central Nervous System; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects | 2006 |
Is plasma homocysteine a modifiable risk factor for stroke?
Topics: Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Stroke; Thrombosis; Vitamins | 2006 |
Homocysteine hypothesis for atherothrombotic cardiovascular disease: not validated.
Topics: Atherosclerosis; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Prospective Studies; Risk Factors; Thrombosis; Treatment Outcome | 2006 |
Synergy of genes and nutrients: the case of homocysteine.
Topics: Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Mood Disorders; Neoplasms; Public Health; Selection, Genetic; Vitamin B 12 Deficiency; Vitamin B Complex | 2006 |
Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence.
Topics: Cardiovascular Diseases; Causality; Cohort Studies; Evidence-Based Medicine; Folic Acid; Homocysteine; Homocystinuria; Humans; Polymorphism, Genetic; Randomized Controlled Trials as Topic | 2006 |
Biochemistry of homocysteine in health and diseases.
Topics: Animals; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Models, Chemical; Oxidative Stress; Smoking; Thrombosis; Vitamin B 12; Vitamin B 6 | 2006 |
Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia.
Topics: Cardiovascular Diseases; Confidence Intervals; Dementia; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Odds Ratio; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12; Vitamin B Complex | 2007 |
[Hyperhomocysteinemia in pediatric age and nutritional aspects of folates: an early cardiovascular risk factor].
Topics: Atherosclerosis; Cardiovascular Diseases; Drug Therapy, Combination; Endothelium; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2006 |
[Risk factors for cardiovascular diseases: what is the role for homocysteine?].
Topics: Cardiovascular Diseases; Folic Acid; Follow-Up Studies; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Vitamin B 12; Vitamin B 6 | 2007 |
[The role of homocysteine thiolactone in some of human diseases].
Topics: Animals; Aryldialkylphosphatase; Atherosclerosis; Biomarkers; Fibrinogen; Folic Acid; Homocysteine; Humans; Lipoproteins, HDL; Rabbits; Stroke; Vitamin B 12; Vitamin B 6 | 2006 |
The homocysteine hypothesis of depression.
Topics: Age Factors; Aged; Aged, 80 and over; Cardiovascular Diseases; Child; Comorbidity; Depressive Disorder; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mutation; Neurotransmitter Agents; Stroke; Vitamin B 12; Vitamin B 6 | 2007 |
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk; Stroke; Vitamin B Complex | 2007 |
[Nutritional medicine 2007].
Topics: Cardiovascular Diseases; Diet; Evidence-Based Medicine; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Practice Guidelines as Topic; Primary Prevention; Risk Assessment; Stroke; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Homocysteine lowering and cardiovascular disease risk: lost in translation.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Risk Factors; Survival Rate; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Homocysteine and cardiovascular disease: a review of the evidence.
Topics: Biomarkers; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypolipidemic Agents; Risk Assessment; Risk Factors; Treatment Outcome; Up-Regulation; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
[Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders--current evidence and preliminary recommendations].
Topics: Aged; Central Nervous System; Child; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mental Disorders; Nervous System Diseases; Parkinson Disease; Risk Factors; Vitamin B 12; Vitamin B Deficiency | 2007 |
Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials.
Topics: Cardiovascular Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B Complex | 2007 |
Penman Lecture. Breast cancer--diet to genes: presented at the Department of Surgery, University of Cape Town, 20 July 2005.
Topics: Biomarkers, Tumor; Breast Neoplasms; Dietary Supplements; DNA Damage; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Glycoproteins; Homocysteine; Humans; Middle Aged; Neoplasm Proteins; Nutritional Status; Prognosis; Risk Factors | 2007 |
Biomarkers of folate and vitamin B(12) status in cerebrospinal fluid.
Topics: Biomarkers; Brain; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2007 |
Homocysteine and cerebral stroke in developing countries.
Topics: Developing Countries; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Metabolic Networks and Pathways; Nutritional Status; Stroke; Vitamin B 12 | 2007 |
Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Renal Dialysis | 2007 |
Homocysteine, vitamins, and vascular disease prevention.
Topics: Aged; Atherosclerosis; Dietary Supplements; Folic Acid; Homocysteine; Humans; Vascular Diseases; Vitamin B 12; Vitamin B 6 | 2007 |
[Cystathionine betasynthase and MTHFR deficiencies in adults].
Topics: Animals; Folic Acid; Homocysteine; Homocystinuria; Humans; Magnetic Resonance Imaging; Nervous System Diseases; Tetrahydrofolate Dehydrogenase | 2007 |
Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why?
Topics: Alzheimer Disease; Animals; Arachidonic Acid; Cognition; Dementia; Depression; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Folic Acid; Homocysteine; Humans; Inflammation Mediators; Nitric Oxide | 2008 |
Importance of folate-homocysteine homeostasis during early embryonic development.
Topics: Animals; Autoantibodies; Biological Transport; Carrier Proteins; Embryonic Development; Folate Receptors, GPI-Anchored; Folic Acid; Homeostasis; Homocysteine; Mice; Mice, Knockout; Preconception Care; Receptors, Cell Surface | 2007 |
Vitamins and stroke: the homocysteine hypothesis still in doubt.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Dietary Supplements; Folic Acid; Homocysteine; Humans; Intracranial Arteriosclerosis; Stroke; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2008 |
[Measurement of methylmalonic acid, homocysteine and methionine in cobalamin and folate deficiencies and homocysteinuria].
Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Diagnosis, Differential; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Infant; Infant, Newborn; Methionine; Methylmalonic Acid; Vitamin B 12 Deficiency | 2008 |
Folate and unipolar depression.
Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Drug Therapy, Combination; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Treatment Outcome | 2008 |
Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease.
Topics: Animals; Atherosclerosis; Cardiovascular Agents; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Heart Defects, Congenital; Hemodynamics; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III | 2008 |
[Should patients with chronic renal insufficiency be treated with folic acid, vitamin B6 and vitamin B12?].
Topics: Drug Therapy, Combination; Evidence-Based Medicine; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Renal Insufficiency, Chronic; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Homocysteine, B-vitamins and CVD.
Topics: Cardiovascular Diseases; Folic Acid; Food, Fortified; Genetic Predisposition to Disease; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutrition Policy; Nutritional Status; Polymorphism, Genetic; Vitamin B Complex | 2008 |
[Biochemical alterations in patients with Down syndrome].
Topics: Acetylglucosaminidase; Adult; Alzheimer Disease; Antioxidants; Bilirubin; Blood Proteins; Cystathionine beta-Synthase; Disease Progression; Down Syndrome; Ferritins; Folic Acid; Homocysteine; Humans; Learning; Nootropic Agents; Quality of Life; S100 Proteins; Serum Albumin; Superoxide Dismutase; Transferrin; Vitamin B 12 | 2008 |
Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status.
Topics: Adult; Aged; Biomarkers; Diet; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Nutritional Requirements; Nutritional Status; Riboflavin; Vitamin B 12; Vitamin B 6; Vitamins | 2008 |
[Do folates have an impact on fertility?].
Topics: DNA Methylation; Female; Fertility; Folic Acid; Homocysteine; Humans; Infertility; Male; Pregnancy; Pregnancy Complications; Reproduction; Vitamin B Complex | 2008 |
Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies.
Topics: Biomarkers; Diagnosis, Differential; Erythrocyte Indices; Erythrocytes; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Nutrition Assessment; Nutritional Status; Sensitivity and Specificity; Sentinel Surveillance; Transcobalamins; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status.
Topics: Biomarkers; Erythrocytes; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Methylmalonic Acid; Nutrition Assessment; Nutritional Status; Reference Standards; Reference Values; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
Public health significance of elevated homocysteine.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Dementia; Diet; Female; Folic Acid; Fractures, Bone; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Neural Tube Defects; Pregnancy; Public Health; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
The worldwide challenge of the dementias: a role for B vitamins and homocysteine?
Topics: Aged; Aged, 80 and over; Aging; Dementia; Environment; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12; Vitamin B Complex | 2008 |
The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis.
Topics: Aged; Carotid Arteries; Dietary Supplements; Double-Blind Method; Down-Regulation; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Regional Blood Flow; Stroke; Time Factors; Treatment Outcome; Tunica Intima; Tunica Media; Vasodilation; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Premature atherosclerotic cardiovascular disease and systemic lupus erythematosus from bedside to bench.
Topics: Age of Onset; Animals; Atherosclerosis; Biomarkers; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Lupus Erythematosus, Systemic; Rupture; Up-Regulation | 2008 |
Homocysteine and depression in later life.
Topics: Age Factors; Aged; Cohort Studies; Depressive Disorder; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Personality Inventory; Polymorphism, Genetic; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12 | 2008 |
Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials.
Topics: Clinical Trials as Topic; Coronary Artery Disease; Folic Acid; Food, Fortified; Homocysteine; Humans; Oxidation-Reduction; Vitamin B Complex; Vitamins | 2009 |
Too much folate: a risk factor for cancer and cardiovascular disease?
Topics: Adenoma; Cardiovascular Diseases; Chronic Disease; Colorectal Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Epigenesis, Genetic; Folic Acid; Homocysteine; Humans; Neoplasms; Risk Factors | 2009 |
The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.
Topics: Clinical Trials as Topic; DNA Mutational Analysis; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Metabolic Networks and Pathways; Models, Biological; Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Research | 2009 |
Folic acid, methylation and neural tube closure in humans.
Topics: Female; Folic Acid; Genetic Variation; Homocysteine; Humans; Metabolic Networks and Pathways; Methylation; Methyltransferases; Models, Biological; Neural Tube; Neural Tube Defects; Pregnancy | 2009 |
Nutritional interpretation of folic acid interventions.
Topics: Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects | 2009 |
Folic acid, neurodegenerative and neuropsychiatric disease.
Topics: Aging; Alzheimer Disease; Animals; Brain; Clinical Trials as Topic; Dementia, Vascular; Depression; Female; Folic Acid; Homocysteine; Humans; Male; Mental Disorders; Molecular Structure; Neurodegenerative Diseases; Neuronal Plasticity; Stroke; Vitamin B Complex | 2009 |
[Present role of homocysteine in clinical medicine].
Topics: Adolescent; Adult; Cardiovascular Diseases; Child; Child, Preschool; Ectopia Lentis; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Infant; Infant, Newborn; Life Style; Male; Middle Aged; Myopia; Pregnancy; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2009 |
Homocysteine as a risk factor for cardiovascular disease in patients treated by dialysis: a meta-analysis.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Prospective Studies; Renal Dialysis; Retrospective Studies; Risk Factors; Vitamin B 12 | 2009 |
[Does diet affect our mood? The significance of folic acid and homocysteine].
Topics: Affect; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Mood Disorders; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency | 2009 |
Cobalamin, folic acid, and homocysteine.
Topics: Adult; Aged; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2009 |
Homocysteine and peripheral arterial disease: systematic review and meta-analysis.
Topics: Aged; Aged, 80 and over; Biomarkers; Dietary Supplements; Evidence-Based Medicine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Peripheral Vascular Diseases; Treatment Outcome; Up-Regulation | 2009 |
Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.
Topics: Adult; Clinical Trials as Topic; Cognition Disorders; Cross-Sectional Studies; Dietary Supplements; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2009 |
Alterations in homocysteine metabolism among alcohol dependent patients--clinical, pathobiochemical and genetic aspects.
Topics: Alcohol Withdrawal Seizures; Alcoholism; Alleles; DNA Methylation; Dopamine; Epigenesis, Genetic; Ethanol; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Myocardial Infarction; Polymorphism, Single Nucleotide; Receptors, N-Methyl-D-Aspartate; Reward; Risk Factors; Social Environment; Vitamin B 12; Vitamin B 6 | 2008 |
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.
Topics: Adult; Chromosomes, Human; DNA-Binding Proteins; Female; Folic Acid; Genome-Wide Association Study; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Transcription Factors; Vitamin B 12 | 2009 |
[Hyperhomocysteinemia and cardiometabolic risk].
Topics: Biomarkers; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Deficiency; Vitamins | 2009 |
Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations.
Topics: Folic Acid; Homocysteine; Humans; Mental Disorders; Nervous System Diseases; Vitamin B 12 | 2009 |
Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials.
Topics: Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B Complex | 2010 |
Genetics of homocysteine metabolism and associated disorders.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylation; Methylenetetrahydrofolate Dehydrogenase (NAD+); Severity of Illness Index; Vitamin B 12; Vitamin B 6 | 2010 |
Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies.
Topics: Folic Acid; Genetic Association Studies; Genetic Variation; Homocysteine; Humans; Inflammatory Bowel Diseases; Metabolic Networks and Pathways; Risk | 2010 |
Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability.
Topics: DNA Methylation; Female; Fertility; Fetal Development; Folic Acid; Folic Acid Deficiency; Genetic Variation; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Pregnancy Maintenance; Pregnancy Outcome | 2010 |
[Disturbances of homocysteine metabolism as a risk factor of cardiovascular diseases development: effect on prognosis and possibilities of correction with drugs].
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Prognosis; Risk Factors; Russia; Vitamin B Complex | 2010 |
Efficacy of homocysteine-lowering therapy with folic Acid in stroke prevention: a meta-analysis.
Topics: Female; Folic Acid; Homocysteine; Humans; Male; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Stroke; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2010 |
Clinical diagnostics for homocysteine: a rogue amino acid?
Topics: Animals; Avitaminosis; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Mental Disorders; Molecular Structure; Neurodegenerative Diseases; Oxidation-Reduction; Pathology, Molecular; Pregnancy; Pregnancy Complications | 2010 |
Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis.
Topics: Aged; Case-Control Studies; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prostatic Neoplasms; Risk Factors; Transcobalamins; Vitamin B 12 | 2010 |
The homocysteine controversy.
Topics: Animals; Dissent and Disputes; Epidemiologic Research Design; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mendelian Randomization Analysis; Models, Biological; Severity of Illness Index; Vitamin B Complex | 2011 |
Genetic polymorphisms in homocysteine metabolism and response to folate intake: a comprehensive strategy to elucidate useful genetic information.
Topics: Bibliometrics; Folic Acid; Genetic Association Studies; Genome-Wide Association Study; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic | 2010 |
Teratogenicity and underlying mechanisms of homocysteine in animal models: a review.
Topics: Abnormalities, Drug-Induced; Animals; Chickens; Congenital Abnormalities; Embryonic Development; Female; Fetal Development; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mice; Neural Crest; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Rats; Teratogens | 2010 |
Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels.
Topics: Aged; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors | 2010 |
Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials.
Topics: Capsules; Double-Blind Method; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Patient Compliance; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2010 |
Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.
Topics: Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Models, Biological; Neural Tube Defects; Pregnancy; Risk Factors | 2011 |
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.
Topics: Biomarkers; Cardiovascular Diseases; Cause of Death; Confidence Intervals; Dietary Supplements; Folic Acid; Homocysteine; Humans; Incidence; Neoplasms; Randomized Controlled Trials as Topic; Stroke; Treatment Failure; Vitamin B Complex | 2010 |
Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials.
Topics: Cause of Death; Clinical Trials as Topic; Dietary Supplements; Down-Regulation; Folic Acid; Homocysteine; Humans; Neoplasms; Vascular Diseases; Vitamin B Complex | 2011 |
Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis.
Topics: Adult; Aged; Cardiovascular Diseases; Dietary Supplements; Evidence-Based Medicine; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Patient Selection; Randomized Controlled Trials as Topic; Renal Dialysis; Risk Assessment; Risk Factors; Treatment Outcome | 2011 |
The homocysteine hypothesis: still relevant to the prevention and treatment of cardiovascular disease?
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Primary Prevention; Vitamin B 6; Vitamin B Complex | 2010 |
Folate in smokers.
Topics: Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Risk Factors; Smoking | 2011 |
Homocysteine in pregnancy.
Topics: Animals; Biomarkers; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Reproduction | 2011 |
Genetic variation: impact on folate (and choline) bioefficacy.
Topics: Biological Availability; Choline; Epistasis, Genetic; Folic Acid; Genetic Variation; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2) | 2010 |
Meta-analysis of the relationship between homocysteine, vitamin B₁₂, folate, and multiple sclerosis.
Topics: Folic Acid; Homocysteine; Humans; Multiple Sclerosis; Vitamin B 12 | 2011 |
Overview of a roundtable on NHANES monitoring of biomarkers of folate and vitamin B-12 status: measurement procedure issues.
Topics: Biomarkers; Chromatography, Liquid; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Nutrition Surveys; Tandem Mass Spectrometry; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Folate and vitamin B-12 biomarkers in NHANES: history of their measurement and use.
Topics: Bias; Biomarkers; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Nutrition Surveys; Public Policy; Vitamin B 12 | 2011 |
[Genes involved in folate metabolim and neural tube defects].
Topics: Female; Folic Acid; Folic Acid Transporters; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Pregnancy; Reduced Folate Carrier Protein; Risk Factors | 2011 |
Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression.
Topics: Aged; Alzheimer Disease; Dementia; Dementia, Vascular; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Odds Ratio; Regression Analysis; Risk Factors; Vitamin B 12 | 2011 |
Nutrients and infertility: an alternative perspective.
Topics: Antioxidants; Dietary Supplements; Embryo Transfer; Female; Fertilization in Vitro; Folic Acid; Homocysteine; Humans; Infertility; Inositol; Reactive Oxygen Species; Selenium | 2011 |
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Vitamin B Complex | 2011 |
Meta-analysis: hyperhomocysteinaemia in inflammatory bowel diseases.
Topics: Case-Control Studies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Genetic; Risk Factors; Thromboembolism | 2011 |
Health effects of mixed fruit and vegetable concentrates: a systematic review of the clinical interventions.
Topics: Antioxidants; Ascorbic Acid; beta Carotene; Diet; Feeding Behavior; Folic Acid; Fruit; Homocysteine; Humans; Oxidation-Reduction; Oxidative Stress; Randomized Controlled Trials as Topic; Vegetables; Vitamin E; Vitamins | 2011 |
Enzymatic and non-enzymatic antioxidative effects of folic acid and its reduced derivates.
Topics: Animals; Antioxidants; Folic Acid; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Lipid Peroxidation; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress | 2012 |
Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis.
Topics: Aged; Exfoliation Syndrome; Folic Acid; Genotype; Glaucoma, Open-Angle; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2012 |
C(1) metabolism and CVD outcomes in older adults.
Topics: Blood Pressure; Carbon; Cardiovascular Diseases; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Diseases; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Riboflavin; Stroke; Vitamin B Complex | 2012 |
Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials.
Topics: Adult; Aged; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Disease Progression; Evidence-Based Medicine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Treatment Outcome; Vitamin B Complex | 2012 |
Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials.
Topics: Cognition Disorders; Dietary Supplements; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2012 |
Homocysteine-lowering therapy does not lead to reduction in cardiovascular outcomes in chronic kidney disease patients: a meta-analysis of randomised, controlled trials.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Randomized Controlled Trials as Topic | 2012 |
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.
Topics: Alleles; Animals; Carbon; Chromatin; DNA Methylation; DNA Modification Methylases; Epigenomics; Folic Acid; Genetic Variation; Homocysteine; Humans; Mitochondria; Models, Biological; Nutritional Sciences; Polymorphism, Genetic; Vitamin B Complex | 2011 |
Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.
Topics: Bias; Coronary Disease; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors | 2012 |
[The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cardiovascular Diseases; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2012 |
Methionine, homocysteine, one carbon metabolism and fetal growth.
Topics: Adult; Animals; Carbon; Dietary Proteins; Energy Intake; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Methionine; Pregnancy; Rats; Vitamin B 12; Vitamins | 2012 |
Leukoencephalopathies associated with disorders of cobalamin and folate metabolism.
Topics: Cobamides; Folic Acid; Homocysteine; Humans; Infant, Newborn; Leukoencephalopathies; Neonatal Screening; Tetrahydrofolates; Vitamin B 12 | 2012 |
[Homocysteine, vitamin B-12, folic acid and the cognitive decline in the elderly].
Topics: Aged; Brain; Cognition Disorders; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Neurodegenerative Diseases; Nutritional Physiological Phenomena; Receptors, N-Methyl-D-Aspartate; Risk Factors; Vitamin B 12 | 2013 |
Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis.
Topics: Aged; Blood Glucose; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dietary Supplements; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Vitamin B Complex | 2012 |
The role of B vitamins in preventing and treating cognitive impairment and decline.
Topics: Alzheimer Disease; Cognition; Cognition Disorders; Folic Acid; Homocysteine; Humans; Methylation; Vitamin B 12; Vitamin B Complex; Vitamin B Deficiency | 2012 |
Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer's disease.
Topics: Alzheimer Disease; Atherosclerosis; Cognition; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B Complex | 2013 |
Folate, homocysteine and the cardiac neural crest.
Topics: Animals; DNA Methylation; Folate Receptor 1; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Mitosis; Neural Crest | 2013 |
Folate-genetics and colorectal neoplasia: what we know and need to know next.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Colorectal Neoplasms; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Risk Factors; S-Adenosylmethionine; Thymidylate Synthase | 2013 |
Red cell or serum folate: what to do in clinical practice?
Topics: Chromatography, High Pressure Liquid; Dietary Supplements; Erythrocytes; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Tandem Mass Spectrometry | 2013 |
Nutritional modulation of cognitive function and mental health.
Topics: Animals; Antioxidants; Brain; Chronic Disease; Cognition; Diet, Mediterranean; Disease Models, Animal; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Life Style; Mental Health; Nutritional Physiological Phenomena; Risk Factors; Vitamin B Complex | 2013 |
Folate and B12 in prostate cancer.
Topics: Betaine; Diet; Dietary Supplements; Folic Acid; Homocysteine; Humans; Male; Meta-Analysis as Topic; Prostate-Specific Antigen; Prostatic Neoplasms; Risk Factors; Vitamin B 12 | 2013 |
A focus on homocysteine in autism.
Topics: Animals; Autistic Disorder; Avitaminosis; Body Fluids; Cystathionine beta-Synthase; Diet; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Life Style; Male; Methylenetetrahydrofolate Reductase (NADPH2); Vitamin B 12; Vitamin B 6 | 2013 |
Vitamin B12, folic acid, and bone.
Topics: Bone and Bones; Bone Density; Dietary Supplements; Folic Acid; Fractures, Bone; Homocysteine; Humans; Prevalence; Vitamin B 12 | 2013 |
Homocysteine lowering interventions for peripheral arterial disease and bypass grafts.
Topics: Arteriosclerosis; Disease Progression; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Peripheral Vascular Diseases; Randomized Controlled Trials as Topic; Tetrahydrofolates; Vascular Grafting; Vitamin B Complex | 2013 |
Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology.
Topics: Cardiovascular Diseases; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Oxidation-Reduction; Randomized Controlled Trials as Topic; Vitamin B Complex; Vitamin B Deficiency; Vitamins | 2013 |
Recent advances in understanding the genetics of congenital heart defects.
Topics: Child; Child, Preschool; DNA Copy Number Variations; Folic Acid; Gene-Environment Interaction; Genes, Modifier; Genome-Wide Association Study; Heart Defects, Congenital; Homocysteine; Humans; Infant; Molecular Sequence Data; Mutation | 2013 |
The role of folic acid fortification in neural tube defects: a review.
Topics: Biological Availability; Choline; Edible Grain; Female; Folic Acid; Folic Acid Antagonists; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Pregnancy; Recommended Dietary Allowances; United States; Vitamin B 12 | 2013 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine | 2013 |
Neural tube defects, folic acid and methylation.
Topics: Animals; Choline; Folic Acid; Homocysteine; Humans; Methylation; Neural Tube Defects; Neurulation; Vitamin B 12; Vitamin B Complex | 2013 |
Association of homocysteine, vitamin B12, and folate with bone mineral density in postmenopausal women: a meta-analysis.
Topics: Bone Density; Case-Control Studies; China; Cohort Studies; Confidence Intervals; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Osteoporosis, Postmenopausal; Postmenopause; Vitamin B 12 | 2014 |
Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review.
Topics: Animals; Epigenesis, Genetic; Fatigue Syndrome, Chronic; Folic Acid; Folic Acid Deficiency; Gene-Environment Interaction; Homocysteine; Humans; Methionine; Neural Tube Defects; Progeria | 2014 |
Biomarker responses to folic acid intervention in healthy adults: a meta-analysis of randomized controlled trials.
Topics: Biomarkers; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Erythrocytes; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic; Reproducibility of Results; Sensitivity and Specificity | 2014 |
The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity.
Topics: Adiposity; Carbon Cycle; Diabetes Mellitus, Type 2; Environmental Exposure; Female; Fetal Development; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant, Newborn; Insulin Resistance; Male; Maternal Nutritional Physiological Phenomena; Methylmalonic Acid; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; Vitamin B 12; Vitamin B 12 Deficiency | 2014 |
Lifetime requirement of the methionine cycle for neuronal development and maintenance.
Topics: Developmental Disabilities; Female; Folic Acid; Homocysteine; Humans; Methionine; Pregnancy; Prenatal Care; S-Adenosylmethionine; Vitamin B 12; Vitamin B Complex | 2014 |
Critical evaluation of lowering the recommended dietary intake of folate.
Topics: Anemia; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Genetic Markers; Homocysteine; Humans; Life Style; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Recommended Dietary Allowances; Treatment Outcome | 2014 |
B-vitamins and bone in health and disease: the current evidence.
Topics: Bone and Bones; Bone Density; Celiac Disease; Folic Acid; Fractures, Bone; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Osteoporosis; Polymorphism, Single Nucleotide; Vitamin B Complex; Vitamin B Deficiency | 2014 |
Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
Topics: Aldehyde Dehydrogenase; Carbon; Folic Acid; Genome-Wide Association Study; Genotype; Homocysteine; Humans; Methionine; Oxidoreductases Acting on CH-NH Group Donors; Stroke; Vitamin B 12 | 2014 |
The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: a meta-analysis of randomized controlled trials.
Topics: Aged; Atherosclerosis; Brachial Artery; Coronary Artery Disease; Dietary Supplements; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Vasodilation | 2014 |
[Hyperhomocysteinemia in patients with cardiovascular disease].
Topics: Cardiovascular Diseases; Causality; Comorbidity; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Myocardial Infarction; Risk Factors; Vitamin B 12 | 2014 |
Critical levels of brain atrophy associated with homocysteine and cognitive decline.
Topics: Atrophy; Brain; Cognition Disorders; Folic Acid; Homocysteine; Humans; Vitamin B 12 Deficiency; Vitamin B Complex | 2014 |
The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis.
Topics: Adult; Aged; Alleles; Biomarkers; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotyping Techniques; Heterozygote; Homocysteine; Humans; Logistic Models; Middle Aged; Mothers; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12; White People | 2014 |
"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".
Topics: Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Odds Ratio; Polymorphism, Single Nucleotide; Pregnancy; Publication Bias; Risk Factors | 2015 |
Folic acid and autism: What do we know?
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Autism Spectrum Disorder; Child; Child Nutritional Physiological Phenomena; Diet; Dietary Supplements; Evidence-Based Medicine; Female; Fetal Development; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Male; Maternal Nutritional Physiological Phenomena; Pregnancy; Reproducibility of Results; Risk Factors | 2016 |
The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.
Topics: Databases, Factual; Folic Acid; Food, Fortified; Homocysteine; Humans; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Vitamin B 12 | 2015 |
Male factors in ART outcome prediction.
Topics: Anti-Mullerian Hormone; Biomarkers; DNA Fragmentation; Female; Folic Acid; Homocysteine; Humans; Infertility, Male; Male; Pregnancy; Pregnancy Rate; Prognosis; Reactive Oxygen Species; Reproductive Techniques, Assisted; Spermatozoa; Treatment Outcome | 2015 |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.
Topics: Diabetes Mellitus; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Infertility; Mental Disorders; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Nervous System Diseases; Polymorphism, Genetic; Psoriasis; Vascular Diseases; Vitamin B 12 | 2015 |
Homocysteine and DNA methylation: a review of animal and human literature.
Topics: Animals; Case-Control Studies; Diet; Dietary Supplements; DNA Methylation; Female; Folic Acid; Gene Knockout Techniques; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Models, Animal; Vitamin B Complex; Vitamin B Deficiency | 2014 |
Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry.
Topics: Alzheimer Disease; Autistic Disorder; Biological Transport; Folic Acid; Homocysteine; Humans; Psychotic Disorders | 2014 |
Homocysteine, iron and cardiovascular disease: a hypothesis.
Topics: Biomarkers; Cardiovascular Diseases; Cystathionine; Dietary Supplements; Folic Acid; Free Radicals; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Lipoproteins, LDL; Methionine; Risk Factors; S-Adenosylhomocysteine; Vitamin B Complex | 2015 |
Quantitative assessment of maternal biomarkers related to one-carbon metabolism and neural tube defects.
Topics: Biomarkers; Carbon; Case-Control Studies; Confidence Intervals; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Vitamin B 12 | 2015 |
Vitamin supplementation as possible prophylactic treatment against migraine with aura and menstrual migraine.
Topics: Adult; Ascorbic Acid; Epilepsy; Female; Folic Acid; Genotype; Homocysteine; Humans; Menstruation; Migraine Disorders; Migraine with Aura; Vitamin B 12; Vitamin B 6; Vitamin E | 2015 |
B vitamins, homocysteine and bone health.
Topics: Bone and Bones; Bone Density; Bone Remodeling; Calcium, Dietary; Folic Acid; Hip Fractures; Homocysteine; Humans; Incidence; Randomized Controlled Trials as Topic; Risk Factors; Thiamine; Vitamin B 6; Vitamin B Complex; Vitamin D | 2015 |
Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses.
Topics: Age Factors; Alzheimer Disease; Databases, Bibliographic; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12 | 2015 |
Interventions for lowering plasma homocysteine levels in kidney transplant recipients.
Topics: Cardiovascular Diseases; Cause of Death; Folic Acid; Homocysteine; Humans; Kidney Transplantation; Randomized Controlled Trials as Topic; Vitamin B Complex | 2015 |
Methylation reactions, the redox balance and atherothrombosis: the search for a link with hydrogen sulfide.
Topics: Animals; Aspirin; Atherosclerosis; Folic Acid; Gasotransmitters; Homocysteine; Humans; Hydrogen Sulfide; Methionine; Methylation; Oxidation-Reduction; Thrombosis | 2015 |
Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case-control studies involving 35,758 individuals.
Topics: Adult; Carcinoma; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Gastrointestinal Neoplasms; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Urologic Neoplasms | 2015 |
Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: A mechanistic and clinical perspective.
Topics: Aspirin; Atherosclerosis; Drug Therapy, Combination; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Primary Prevention; Randomized Controlled Trials as Topic; Thrombosis | 2016 |
Plasma Homocysteine, Serum Folic Acid, Serum Vitamin B12, Serum Vitamin B6, MTHFR, and Risk of Normal-Tension Glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Folic Acid; Genotype; Homocysteine; Humans; Intraocular Pressure; Low Tension Glaucoma; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamins | 2016 |
Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence.
Topics: Aged; Antioxidants; Ascorbic Acid; beta Carotene; Cognition; Cognition Disorders; Dementia; Dietary Supplements; Folic Acid; Homocysteine; Humans; Meta-Analysis as Topic; Vitamin A; Vitamin B 12; Vitamin B 6; Vitamin D; Vitamin D Deficiency; Vitamin E; Vitamins | 2015 |
Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Macular Degeneration; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2015 |
The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies.
Topics: Biomarkers; Databases, Factual; Dietary Supplements; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Observational Studies as Topic; Randomized Controlled Trials as Topic | 2017 |
Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis.
Topics: Aged; Alleles; Asian People; Case-Control Studies; Comorbidity; Coronary Artery Disease; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Homocysteine; Humans; Linkage Disequilibrium; Male; Middle Aged; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Republic of Korea; Risk; Risk Factors | 2015 |
Early pregnancy B vitamin status, one carbon metabolism, pregnancy outcome and child development.
Topics: Betaine; Carbon; Child; Child Development; Child, Preschool; Female; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Infant; Infant, Newborn; Pregnancy; Pregnancy Trimester, Third; Sarcosine; Vitamin B 12 | 2016 |
[Relationship of MTHFR gene polymorphisms with infertility].
Topics: DNA; DNA Methylation; DNA Repair; Folic Acid; Homocysteine; Humans; Infertility; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Prospective Studies | 2016 |
One carbon metabolism and bone homeostasis and remodeling: A review of experimental research and population studies.
Topics: Animals; Bone and Bones; Bone Remodeling; Carbon; Folic Acid; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Osteoblasts; Osteoclasts; Vitamin B 12; Vitamin B Deficiency | 2016 |
A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: A meta-analysis.
Topics: Animals; Dietary Supplements; Drug Therapy, Combination; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Models, Animal; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Vitamin B Complex | 2016 |
Interventions for lowering plasma homocysteine levels in dialysis patients.
Topics: Aged; Cardiovascular Diseases; Cause of Death; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Myocardial Infarction; Renal Dialysis; Stroke; Venous Thrombosis; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2016 |
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis.
Topics: Biomarkers; Cleft Lip; Cleft Palate; Female; Folic Acid; Homocysteine; Humans; Methylation; Pregnancy; Vitamin B 12 | 2016 |
Homocysteine, B Vitamins, and Cognitive Impairment.
Topics: Aging; Animals; Biomarkers; Cerebrovascular Circulation; Cognition Disorders; Cognitive Dysfunction; Dietary Supplements; Evidence-Based Medicine; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Neurodegenerative Diseases; Nootropic Agents; Nutritional Status; Practice Guidelines as Topic; Risk Factors; Vitamin B 12; Vitamin B 6 | 2016 |
[Meta-analysis on effect of combined supplementation of folic acid, vitamin B12 and B6 on risk of cardio-cerebrovascular diseases in randomized control trials].
Topics: Adult; Aged; Cardiovascular Diseases; Dietary Supplements; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Incidence; Middle Aged; Randomized Controlled Trials as Topic; Risk; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2016 |
Homocysteine and cognition: A systematic review of 111 studies.
Topics: Cognition; Cognition Disorders; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2016 |
Elevated homocysteine levels in mothers with neural tube defects: a systematic review and meta-analysis.
Topics: Case-Control Studies; Female; Folic Acid; Hematinics; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2017 |
Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders.
Topics: Alleles; Autism Spectrum Disorder; Autistic Disorder; Child; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors | 2016 |
Association of plasma homocysteine, vitamin B12 and folate levels with cognitive function in Parkinson's disease: A meta-analysis.
Topics: Adult; Aged; Aged, 80 and over; Cognition; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Treatment Outcome; Vitamin B 12 | 2017 |
Is folic acid supplementation useful for chronic kidney disease?
Topics: Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Myocardial Infarction; Renal Insufficiency, Chronic; Risk Factors; Stroke | 2016 |
Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review.
Topics: Blood Pressure; Body Mass Index; China; Creatinine; Diet, Healthy; Dietary Supplements; Exercise; Female; Folic Acid; Fruit; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Life Style; Male; Risk Factors; Triglycerides; Uric Acid; Vegetables; Vitamin B Complex | 2017 |
Oxcarbazepine administration and the serum levels of homocysteine, vitamin B12 and folate in epileptic patients: A systematic review and meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Folic Acid; Homocysteine; Humans; Oxcarbazepine; Vitamin B 12 | 2017 |
Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy.
Topics: Animals; DNA Methylation; Epigenesis, Genetic; Folic Acid; Histones; Homocysteine; Humans; Hyperhomocysteinemia; Metformin; Muscle, Skeletal; Muscular Diseases; Oxidative Stress; RNA Interference; Thiazolidinediones; Vitamin B 12; Vitamin B 6 | 2017 |
Implication of homocysteine in diabetes and impact of folate and vitamin B12 in diabetic population.
Topics: Diabetes Mellitus; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Prevalence; Vitamin B 12 | 2017 |
Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cognition Disorders; Dementia; Dietary Supplements; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2017 |
Vitamin B12, folate, and homocysteine levels and multiple sclerosis: A meta-analysis.
Topics: Folic Acid; Homocysteine; Humans; Multiple Sclerosis; Vitamin B 12 | 2017 |
Homocysteine and Hyperhomocysteinaemia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Avitaminosis; Cystathionine beta-Synthase; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Vitamin B 12; Vitamin B 6 | 2019 |
Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?
Topics: Biopterins; Cardiovascular Diseases; Dietary Supplements; Endothelium, Vascular; Folic Acid; Hemodynamics; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Tetrahydrofolates | 2018 |
Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease.
Topics: Animals; Betaine; Biomarkers; Cardiovascular Diseases; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Phenotype; Risk Factors; Tetrahydrofolates; Treatment Outcome | 2018 |
Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly.
Topics: Adult; Aged; Biomarkers; Diet; Erythrocytes; Folic Acid; Homocysteine; Humans; Observational Studies as Topic; Reference Values | 2018 |
The current status of homocysteine as a risk factor for cardiovascular disease: a mini review.
Topics: Atherosclerosis; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Vitamin B Complex | 2018 |
Serum homocysteine, folate and vitamin B
Topics: Biomarkers; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Psoriasis; Vitamin B 12 | 2019 |
A systematic review of the vitamin B12, folate and homocysteine triad across body mass index.
Topics: Body Mass Index; Folic Acid; Homocysteine; Humans; Obesity; Vitamin B 12 | 2018 |
Serum homocysteine, folate, and vitamin B
Topics: Biomarkers; Case-Control Studies; Folic Acid; Homocysteine; Humans; Severity of Illness Index; Vitamin B 12; Vitiligo | 2019 |
Folate, vitamin B12, and homocysteine in smoking-exposed pregnant women: A systematic review.
Topics: Female; Folic Acid; Homocysteine; Humans; Maternal Exposure; Mothers; Pregnancy; Pregnancy Complications; Smoking; Smoking Cessation; Vitamin B 12 | 2019 |
Homocysteine Modification in Protein Structure/Function and Human Disease.
Topics: Animals; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12 | 2019 |
Targeting MTHFR for the treatment of migraines.
Topics: Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Migraine Disorders; Molecular Targeted Therapy; Polymorphism, Genetic; Vitamin B 12; Vitamin B 6 | 2019 |
Medicines associated with folate-homocysteine-methionine pathway disruption.
Topics: Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Pregnancy; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Vitamin B 12 Deficiency | 2019 |
Benefits of multiple micronutrient supplementation in heart failure: A comprehensive review.
Topics: Amino Acids; Carnitine; Databases, Factual; Dietary Supplements; Energy Metabolism; Fatty Acids, Omega-3; Folic Acid; Heart Failure; Homocysteine; Humans; Magnesium; Micronutrients; Myocardium; Nutrition Therapy; Oxidative Stress; Potassium; Quality of Life; Selenium; Taurine; Ubiquinone; Vitamins | 2019 |
Effect of folate supplementation on insulin sensitivity and type 2 diabetes: a meta-analysis of randomized controlled trials.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Fasting; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Insulin; Insulin Resistance; Male; Randomized Controlled Trials as Topic; Risk Factors | 2019 |
Folic Acid and Vitamin B12 Administration in CKD, Why Not?
Topics: Biomarkers; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Risk Factors; Vitamin B 12 | 2019 |
Disturbed homocysteine metabolism is associated with cancer.
Topics: Alleles; Animals; Cystathionine beta-Synthase; Disease Susceptibility; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Metabolic Networks and Pathways; Neoplasms; Polymorphism, Genetic; Risk Factors; Sulfur; Thromboembolism | 2019 |
Effects of phenytoin on serum levels of homocysteine, vitamin B12, folate in patients with epilepsy: A systematic review and meta-analysis (PRISMA-compliant article).
Topics: Anticonvulsants; Epilepsy; Folic Acid; Homocysteine; Humans; Phenytoin; Research Design; Vitamin B 12 | 2019 |
Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis.
Topics: Aged; Cognition; Cognition Disorders; Dementia; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2019 |
Homocysteine, folic acid, and vitamin B12 levels in patients on isotretinoin therapy for acne vulgaris: A meta-analysis.
Topics: Acne Vulgaris; Administration, Oral; Folic Acid; Homocysteine; Humans; Isotretinoin; Vitamin B 12 | 2020 |
The role of one-carbon metabolism and homocysteine in Parkinson's disease onset, pathology and mechanisms.
Topics: Animals; Diet; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Levodopa; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; One-Carbon Group Transferases; Parkinson Disease; Polymorphism, Genetic; Vitamin B Complex | 2019 |
The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B
Topics: Acne Vulgaris; Folic Acid; Homocysteine; Humans; Isotretinoin; Vitamin B 12 | 2020 |
Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis.
Topics: Adult; Case-Control Studies; China; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Multiple Sclerosis; Vitamin B 12 | 2019 |
Homocysteine and psoriasis.
Topics: Animals; Cytokines; Folic Acid; Homocysteine; Humans; Inflammation; Psoriasis; Vitamin B 12 | 2019 |
Plasma homocysteine, folate and vitamin B12 levels in Parkinson's disease in China: A meta-analysis.
Topics: Case-Control Studies; China; Folic Acid; Homocysteine; Humans; Parkinson Disease; Vitamin B 12 | 2020 |
Serum levels of Homocysteine, Vitamin B12 and Folate in Patients with Multiple Sclerosis: an Updated Meta-Analysis.
Topics: Adult; Case-Control Studies; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multiple Sclerosis; Vitamin B 12 | 2020 |
Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles.
Topics: Cell Line, Tumor; Epigenesis, Genetic; Folic Acid; Homocysteine; Humans; Methionine; Neoplasms; Neoplastic Stem Cells; Vitamin B 12 | 2020 |
Riboflavin Deficiency-Implications for General Human Health and Inborn Errors of Metabolism.
Topics: Acyl-CoA Dehydrogenases; Aging; Animals; Diet; Electron Transport; Energy Metabolism; Fatty Acids; Female; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Folic Acid; Genetic Variation; Homocysteine; Humans; Immune System; Metabolism, Inborn Errors; Mitochondria; Mutation; Phenotype; Pregnancy; Protein Folding; Riboflavin; Riboflavin Deficiency | 2020 |
Dietary Intake of Homocysteine Metabolism-Related B-Vitamins and the Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies.
Topics: Adult; Aged; China; Eating; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Nutrition Surveys; Prospective Studies; Risk Factors; Stroke; Vitamins | 2020 |
Folic acid and RAAS blockers in ischemia/reperfusion-induced hepatic injury: A current mechanistic concept for understanding the incidence, significance & outcome.
Topics: Animals; Drug Synergism; Folic Acid; Homocysteine; Humans; Liver Diseases; Renin-Angiotensin System; Reperfusion Injury; Uric Acid | 2020 |
Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta-Analysis.
Topics: Folic Acid; Homocysteine; Humans; Migraine with Aura; Migraine without Aura; Pyridoxine; Vitamin B 12 | 2020 |
Serum Homocysteine, Folate, and Vitamin B
Topics: Adult; Folic Acid; Homocysteine; Humans; Lupus Erythematosus, Systemic; Vitamin B 12; Vitamins | 2021 |
Gut microbiota and the periodontal disease: role of hyperhomocysteinemia.
Topics: Dysbiosis; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Periodontitis; Probiotics | 2021 |
Folic Acid Supplementation in Patients with Elevated Homocysteine Levels.
Topics: Animals; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors | 2020 |
Methionine Nutrition and Metabolism: Insights from Animal Studies to Inform Human Nutrition.
Topics: Animals; Betaine; Choline; Creatine; Cysteine; Diet; Folic Acid; Glutathione; Homocysteine; Humans; Methionine; Methylation; Models, Animal; Nutritional Requirements; Nutritional Status; Phosphatidylcholines; S-Adenosylmethionine; Sulfur | 2020 |
Association between abnormal maternal serum levels of vitamin B12 and preeclampsia: a systematic review and meta-analysis.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Observational Studies as Topic; Pre-Eclampsia; Pregnancy; Vitamin B 12; Young Adult | 2021 |
Epigenetic factors in atherosclerosis: DNA methylation, folic acid metabolism, and intestinal microbiota.
Topics: Atherosclerosis; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Humans; Vitamin B 12 | 2021 |
Homocysteine and diabetes: Role in macrovascular and microvascular complications.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Diabetic Nephropathies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B 12 | 2021 |
Association between neuropathy and B-vitamins: A systematic review and meta-analysis.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Peripheral Nervous System Diseases; Vitamin B 12; Vitamin B Complex | 2021 |
The effect of metformin on homocysteine levels in patients with polycystic ovary syndrome: A systematic review and meta-analysis.
Topics: Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome | 2021 |
The role of B vitamins in stroke prevention.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Stroke; Vitamin B 12; Vitamin B Complex | 2022 |
Serum Vitamins and Homocysteine Levels in Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis.
Topics: Folic Acid; Homocysteine; Humans; Obsessive-Compulsive Disorder; Vitamin B 12; Vitamins | 2021 |
Homocysteine and female fertility, pregnancy loss and offspring birthweight: a two-sample Mendelian randomization study.
Topics: Abortion, Spontaneous; Birth Weight; Female; Fertility; Folic Acid; Genome-Wide Association Study; Homocysteine; Humans; Male; Mendelian Randomization Analysis; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy | 2022 |
A Novel Review of Homocysteine and Pregnancy Complications.
Topics: Abortion, Habitual; Aging; Birth Weight; Diabetes, Gestational; Dietary Supplements; Female; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency | 2021 |
A narrative review on the role of folate-mediated one-carbon metabolism and its associated gene polymorphisms in posing risk to preeclampsia.
Topics: Carbon; Female; Folic Acid; Homocysteine; Humans; Polymorphism, Genetic; Pre-Eclampsia; Pregnancy | 2021 |
Hyperhomocysteinemia and low vitamin B12 are associated with the risk of early pregnancy loss: A clinical study and meta-analyses.
Topics: Abortion, Spontaneous; Adult; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Maternal Nutritional Physiological Phenomena; Meta-Analysis as Topic; Nutritional Status; Odds Ratio; Pregnancy; Pregnancy Complications; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2021 |
[Increased plasma levels of vitamin B12].
Topics: Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
The link between homocysteine, folic acid and vitamin B12 in chronic kidney disease.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Renal Dialysis; Vitamin B 12 | 2021 |
Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
Topics: Aged; Bone Density; Dietary Supplements; Eating; Female; Folic Acid; Fractures, Bone; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B 12; Vitamin B Complex | 2022 |
The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection.
Topics: Brain-Gut Axis; COVID-19; Dietary Supplements; Folic Acid; Homocysteine; Humans; Muscles; SARS-CoV-2; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks.
Topics: Carbon Cycle; Cardiovascular Diseases; Diabetes Mellitus; Epigenesis, Genetic; Female; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vascular Diseases; Vitamin B 12 | 2021 |
Vitamin B-related Gene Polymorphisms and Cardiovascular Disease.
Topics: Aminohydrolases; Cardiovascular Diseases; Folic Acid; Formate-Tetrahydrofolate Ligase; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Neoplasm Proteins; Polymorphism, Genetic; Receptors, Cell Surface; Vitamin B 12; Vitamin B Complex | 2022 |
Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is That Link?
Topics: Animals; Folic Acid; Gasotransmitters; Heart Failure; Homocysteine; Hyperhomocysteinemia; Inflammation; Models, Theoretical; Myocardial Infarction; Vitamin B 6; Vitamins | 2022 |
COVID-19 and One-Carbon Metabolism.
Topics: Carbon; COVID-19; Folic Acid; Homocysteine; Humans; Methionine; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Vitamin B 12 | 2022 |
Problem in the Recent American Heart Association Guideline on Secondary Stroke Prevention: B Vitamins to Lower Homocysteine Do Prevent Stroke.
Topics: American Heart Association; Folic Acid; Homocysteine; Humans; Stroke; Vitamin B 12; Vitamin B Complex | 2022 |
B vitamins and homocysteine as determinants of bone health: A literature review of human studies.
Topics: Bone and Bones; Bone Density; Folic Acid; Fractures, Bone; Homocysteine; Humans; Osteoporosis; Vitamin B 12; Vitamin B Complex | 2023 |
Betaine consumption as a new clinical approach to treatment and prophylaxis of folate-related pathologies.
Topics: Amino Acids; Betaine; Betaine-Homocysteine S-Methyltransferase; Folic Acid; Homocysteine; Humans; Methionine | 2023 |
B vitamins, polycystic ovary syndrome, and fertility.
Topics: Female; Fertility; Folic Acid; Homocysteine; Humans; Polycystic Ovary Syndrome; Vitamin B 12; Vitamin B Complex | 2022 |
Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease.
Topics: Case-Control Studies; Cognitive Dysfunction; Folic Acid; Genetic Background; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Parkinson Disease; Vitamin B 12 | 2023 |
Hyperhomocysteinemia in Cardiovascular Diseases: Revisiting Observational Studies and Clinical Trials.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12 | 2023 |
Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
Topics: Folic Acid; Genome-Wide Association Study; Homocysteine; Humans; Mendelian Randomization Analysis; Non-alcoholic Fatty Liver Disease; Polymorphism, Single Nucleotide | 2022 |
High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Carbon; Choline; Diabetes, Gestational; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Micronutrients; Neural Tube Defects; Pregnancy; Thymidylate Synthase; Vitamin B 12 | 2022 |
Arginine, Transsulfuration, and Folic Acid Pathway Metabolomics in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Topics: Arginine; Cysteine; Folic Acid; Homocysteine; Humans; Metabolomics; Methionine; Nitric Oxide; Racemethionine; Vitamins | 2023 |
Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis.
Topics: Cognitive Dysfunction; Folic Acid; Homocysteine; Humans; Parkinson Disease; Vitamin B 12 | 2023 |
Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis.
Topics: Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Metabolic Syndrome; Vitamin B 12 | 2023 |
Homocysteine as a predictor and prognostic marker of atherosclerotic cardiovascular disease: a systematic review and meta-analysis.
Topics: Aged; Atherosclerosis; Cardiovascular Diseases; Carotid Intima-Media Thickness; Child; Endothelial Cells; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Prognosis; Risk Factors; Vitamin B 12 | 2023 |
Folate and retinal vascular diseases.
Topics: Diabetic Retinopathy; Endothelial Cells; Folic Acid; Glucose; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2023 |
584 trial(s) available for homocysteine and folic acid
| Article | Year |
|---|---|
Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate | 1991 |
Controlled dietary folate affects folate status in nonpregnant women.
Topics: Adult; Dose-Response Relationship, Drug; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Nutrition Assessment; Nutrition Policy | 1995 |
Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.
Topics: Aged; Aged, 80 and over; Avitaminosis; Citrates; Cystathionine; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Injections, Intramuscular; Male; Methylmalonic Acid; Placebos; Prospective Studies; Pyridoxine; Vitamin B 12; Vitamin B 12 Deficiency | 1995 |
Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid.
Topics: Adult; Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Treatment Outcome | 1995 |
Neural tube defects and elevated homocysteine levels in amniotic fluid.
Topics: Adult; Amniotic Fluid; Female; Fetal Diseases; Folic Acid; Gestational Age; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Trimester, Second; Pyridoxine; Vitamin B 12 | 1995 |
Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Arterial Occlusive Diseases; Biomarkers; Blood Pressure; Cholesterol; Endothelium, Vascular; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methionine; Middle Aged; Pyridoxine; Smoking; Thrombomodulin; Time Factors; Tissue Plasminogen Activator; von Willebrand Factor | 1995 |
Vitamin requirements for the treatment of hyperhomocysteinemia in humans.
Topics: Adult; Aged; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Placebos; Pyridoxine; Vitamin B 12 | 1994 |
Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocysteinaemia in vascular patients.
Topics: Amino Acid Metabolism, Inborn Errors; Folic Acid; Homocysteine; Humans; Middle Aged; Pyridoxine; Vascular Diseases | 1994 |
Hyperhomocysteinemia and the response to vitamin supplementation.
Topics: Adolescent; Adult; Aged; Diet; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Vitamin B 12 | 1993 |
The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients.
Topics: Adult; Aged; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Lipids; Lipoproteins; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Pyridoxine; Renal Dialysis; Uremia | 1993 |
Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia.
Topics: Adult; Aged; Cardiovascular Diseases; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Double-Blind Method; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1993 |
Long-term folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level in chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Creatinine; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Pyridoxine | 1996 |
Folic acid treatment of hyperhomocysteinemia in dialysis patients.
Topics: Adult; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Time Factors | 1996 |
Folate, vitamin B12, and homocysteine in major depressive disorder.
Topics: Adolescent; Adult; Ambulatory Care; Depressive Disorder; Female; Fluoxetine; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Unpredictable intra-individual variations in serum homocysteine levels on folic acid supplementation.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Folic Acid Deficiency; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 1997 |
Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men.
Topics: Aged; Chromosome Aberrations; DNA Damage; Folic Acid; Homocysteine; Humans; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Middle Aged; Vitamin B 12 | 1997 |
Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid.
Topics: Adult; Aged; Analysis of Variance; Cardiovascular Diseases; Drug Administration Schedule; Folic Acid; Homocysteine; Humans; Male; Middle Aged | 1997 |
Metformin increases total serum homocysteine levels in non-diabetic male patients with coronary heart disease.
Topics: Adult; Coronary Disease; Cysteine; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Methylmalonic Acid; Middle Aged; Vitamin B 12 | 1997 |
Treatment of hyperhomocysteinemia in renal transplant recipients. A randomized, placebo-controlled trial.
Topics: Drug Therapy, Combination; Factor Analysis, Statistical; Folic Acid; Homocysteine; Humans; Kidney Transplantation; Methionine; Pyridoxine; Risk Factors; Vitamin B 12 | 1997 |
5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
Topics: Adult; Biological Availability; Dose-Response Relationship, Drug; Endothelium; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Hyperlipoproteinemia Type II; Hypoxanthine; Male; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Superoxides; Tetrahydrofolates; Vasodilation; Xanthine Oxidase | 1998 |
No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in haemodialysis patients.
Topics: Adult; Aged; Betaine; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Renal Dialysis | 1998 |
The C677T mutation in the methylenetetrahydrofolate reductase gene predisposes to hyperhomocysteinemia in children with familial hypercholesterolemia treated with cholestyramine.
Topics: Anticholesteremic Agents; Child; Cholestyramine Resin; Female; Folic Acid; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Hyperlipoproteinemia Type II; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors | 1998 |
Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers.
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Reference Values; Thrombophlebitis | 1998 |
Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 1998 |
Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease.
Topics: Aged; Aged, 80 and over; Coronary Disease; Cross-Over Studies; Double-Blind Method; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Homocystine; Humans; Male; Middle Aged; Nutrition Policy; Vitamins | 1998 |
677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Aged, 80 and over; Analysis of Variance; Cerebrovascular Disorders; Female; Folic Acid; Homocysteine; Humans; Ischemic Attack, Transient; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases; Risk Factors; Vitamin B 12 | 1998 |
Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial.
Topics: Adult; Age Factors; Analysis of Variance; Antioxidants; Ascorbic Acid; beta Carotene; Blood Pressure; Body Mass Index; Cholesterol; Diastole; Dietary Supplements; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Reference Values; Smoking; Systole; Triglycerides; Vitamin B 12; Vitamin E | 1998 |
[Recommended dietary allowance of folic acid is insufficient for optimal homocysteine levels].
Topics: Adult; Aged; Arteriosclerosis; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Netherlands; Nutrition Policy; Prospective Studies; Pyridoxine; Reference Values | 1998 |
Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults.
Topics: Adult; Chromosome Aberrations; Cross-Sectional Studies; Dietary Supplements; DNA; DNA Damage; DNA Methylation; Double-Blind Method; Female; Folic Acid; Hematinics; Homocysteine; Humans; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Placebos; Vitamin B 12 | 1998 |
The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
Topics: Adult; Cysteine; Diet; Double-Blind Method; Edible Grain; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Placebos; Vitamin B 12 | 1998 |
Effective treatment of cobalamin deficiency with oral cobalamin.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Folic Acid; Hematocrit; Homocysteine; Humans; Injections, Intramuscular; Male; Methylmalonic Acid; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 1998 |
Plasma homocyst(e)ine concentrations in pregnant and nonpregnant women with controlled folate intake.
Topics: Adolescent; Adult; Female; Folic Acid; Homocysteine; Humans; Pregnancy; Pregnancy Trimester, Second | 1998 |
Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction.
Topics: Dietary Supplements; Female; Fetal Growth Retardation; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Medical History Taking; Methionine; Pre-Eclampsia; Pregnancy; Pyridoxine; Statistics, Nonparametric | 1998 |
Changes in folate status as determined by reduction in total plasma homocysteine levels during leucovorin modulation of 5-fluorouracil therapy in cancer patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colorectal Neoplasms; Creatinine; Erythrocytes; Female; Fluorouracil; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Middle Aged; Vitamin B 12 | 1998 |
Elevated homocysteine levels indicate suboptimal folate status in pediatric sickle cell patients.
Topics: Adolescent; Anemia, Sickle Cell; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Hemoglobin SC Disease; Homocysteine; Humans; Infant; Male; Pyridoxine; Vitamin B 12 | 1998 |
Correlation between total homocysteine and cyclosporine concentrations in cardiac transplant recipients.
Topics: Adult; Aged; Cyclosporine; Female; Folic Acid; Heart Transplantation; Homocysteine; Humans; Immunosuppressive Agents; Kidney Glomerulus; Linear Models; Male; Metabolic Diseases; Methionine; Middle Aged; Postoperative Complications; Vitamin B 12 | 1998 |
Effects of folic acid and combinations of folic acid and vitamin B-12 on plasma homocysteine concentrations in healthy, young women.
Topics: Adult; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 1998 |
Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial.
Topics: Adult; Analysis of Variance; Body Mass Index; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans | 1999 |
Maternal folate status during extended lactation and the effect of supplemental folic acid.
Topics: Adult; Analysis of Variance; Anthropometry; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Hematologic Tests; Homocysteine; Humans; Infant, Newborn; Lactation; Longitudinal Studies; Milk, Human | 1999 |
Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients.
Topics: Adult; Betaine; Fasting; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methionine; Methylation; Middle Aged; Renal Dialysis; Time Factors; Treatment Outcome | 1999 |
Folate nutriture alters choline status of women and men fed low choline diets.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Choline; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lipids; Male; Methionine; Methylation; Middle Aged; Nutritional Physiological Phenomena; Nutritional Status; Phosphatidylcholines; Reference Values; S-Adenosylmethionine | 1999 |
Folate administration reduces circulating homocysteine levels in NIDDM patients on long-term metformin treatment.
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dipeptides; Double-Blind Method; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Prospective Studies; Risk Factors; Time Factors; Treatment Outcome; Vitamin B 12 | 1998 |
Association of the 677C-->T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects.
Topics: Adult; Alleles; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Turkey | 1999 |
Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.
Topics: Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pyridoxine; Single-Blind Method; Vitamin B 12 | 1999 |
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Digestive System; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sulfasalazine; Vitamin B 12 | 1999 |
Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate.
Topics: Administration, Oral; Adult; Cholesterol; Cysteine; Dipeptides; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins; Male; Middle Aged; Norway; Pyridoxal Phosphate; Pyridoxic Acid; Pyridoxine; Vitamin B 12 | 1999 |
Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial.
Topics: Adolescent; Adult; Biological Availability; Citrus; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Osmolar Concentration; Vegetables | 1999 |
Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Function Tests; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Regression Analysis; Risk Assessment; Risk Factors; Statistics, Nonparametric; Vitamin B 12 | 1999 |
Lowering of homocysteine concentrations in elderly men and women.
Topics: Aged; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Pyridoxine; Vitamin B 12 | 1999 |
Serum homocysteine increases after therapy with fenofibrate or bezafibrate.
Topics: Adult; Bezafibrate; Chromatography, High Pressure Liquid; Fenofibrate; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Hypertriglyceridemia; Hypolipidemic Agents; Male; Middle Aged; Pilot Projects; Pyridoxine; Vitamin B 12 | 1999 |
Variability of fasting and post-methionine plasma homocysteine levels in normo- and hyperhomocysteinaemic individuals.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Analysis of Variance; Fasting; Female; Folic Acid; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases; Statistics, Nonparametric | 1999 |
Oral folate enhances endothelial function in hyperhomocysteinaemic subjects.
Topics: Administration, Oral; Adult; Blood Flow Velocity; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Risk Factors; Vascular Diseases; Vasodilation | 1999 |
Elevated serum levels of methylmalonic acid and homocysteine in elderly people. A population-based intervention study.
Topics: Administration, Oral; Aged; Female; Folic Acid; Hematinics; Homocysteine; Humans; Injections, Intramuscular; Male; Methylmalonic Acid; Treatment Outcome; Vitamin B 12 | 1999 |
Long-term diuretic therapy in hypertensive patients: effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations.
Topics: Diuretics; Female; Folic Acid; Homocysteine; Humans; Hypertension; Linear Models; Male; Middle Aged; Prospective Studies; Pyridoxine; Statistics, Nonparametric; Time Factors; Vitamin B 12 | 1999 |
Micronucleus frequency in human lymphocytes is related to plasma vitamin B12 and homocysteine.
Topics: Adolescent; Adult; Aged; Cell Division; Cross-Sectional Studies; Double-Blind Method; Environmental Monitoring; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lymphocytes; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Folic Acid; Genotype; Homocysteine; Humans; Isoenzymes; Male; Middle Aged; Polymorphism, Genetic; Pyridoxine; Vitamin B 12 | 1999 |
Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease.
Topics: Adult; Aged; Analysis of Variance; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Pyridoxine; Risk Factors; Vitamin B 12 | 1999 |
Folic acid improves arterial endothelial function in adults with hyperhomocystinemia.
Topics: Administration, Oral; Adult; Aged; Arteriosclerosis; Brachial Artery; Cholesterol; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Observer Variation; Treatment Outcome; Ultrasonography; Vasodilation | 1999 |
Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients.
Topics: Adult; Fasting; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Logistic Models; Male; Middle Aged; Postoperative Complications; Renal Dialysis; Renal Insufficiency | 1999 |
Elevated serum levels of methylmalonic acid and homocysteine in elderly people. A population-based intervention study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Injections, Intramuscular; Male; Methylmalonic Acid; Population Surveillance; Treatment Outcome; Vitamin B 12 | 1999 |
A tale of two homocysteines--and two hemodialysis units.
Topics: Aged; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Cystine; Female; Fluorometry; Folic Acid; Hematinics; Hemodialysis Units, Hospital; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Regression Analysis; Vitamin B 12 | 2000 |
Low-dose folic acid supplementation does not influence plasma methionine concentrations in young non-pregnant women.
Topics: Adolescent; Adult; Contraceptives, Oral; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Vitamin B 12 | 1999 |
The plasma homocysteine concentration is better than that of serum methylmalonic acid as a marker for sociopsychological performance in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Dementia; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Acid; Psychiatric Status Rating Scales; Regression Analysis; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Serum homocysteine, folate and thermolabile variant of MTHFR in healthy Sri Lankans living in London.
Topics: Adult; Coronary Disease; Emigration and Immigration; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Homocysteine; Humans; London; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Reference Values; Sri Lanka | 2000 |
Folate status of elderly women following moderate folate depletion responds only to a higher folate intake.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Chromatography, High Pressure Liquid; Diet; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Middle Aged; Nutritional Status | 2000 |
Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Coronary Disease; Cystathionine beta-Synthase; Female; Folic Acid; Genotype; Haplotypes; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors; Treatment Outcome | 2000 |
Dietary strategies for lowering homocysteine concentrations.
Topics: Adult; Aged; Blood Glucose; Body Weight; Diet; Dietary Supplements; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Lipoproteins; Male; Middle Aged; Vitamin B 12 | 2000 |
Controlled comparison of L-5-methyltetrahydrofolate versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Renal Dialysis; Tetrahydrofolates; Treatment Failure | 2000 |
A controlled trial of the effect of folate supplements on homocysteine, lipids and hemorheology in end-stage renal disease.
Topics: Adult; Aged; Arteriosclerosis; Double-Blind Method; Female; Folic Acid; Hemorheology; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Lipids; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Risk Factors | 2000 |
Correlates of total plasma homocysteine: folic acid, copper, and cervical dysplasia.
Topics: Case-Control Studies; Contraceptives, Oral; Copper; Diet; Dietary Fats; Dietary Supplements; Erythrocytes; Ethnicity; Fatty Acids, Unsaturated; Female; Folic Acid; Homocysteine; Humans; Linear Models; Risk Factors; Uterine Cervical Dysplasia; Vitamin B 12 | 2000 |
Homocysteine, folate, methylation, and monoamine metabolism in depression.
Topics: Adult; Biogenic Monoamines; Blood Cell Count; Body Weight; Depression; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Methylation; Middle Aged; S-Adenosylmethionine; Vitamin B 12 | 2000 |
The effect of 677C-->T and 1298A-->C mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase activity in healthy subjects.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Female; Folic Acid; Heterozygote; Homocysteine; Homozygote; Humans; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases; Point Mutation; Polymorphism, Genetic; Vitamin B 12 | 2000 |
Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins.
Topics: Aged; Cohort Studies; Female; Folic Acid; Follow-Up Studies; Genotype; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Renal Dialysis; Solubility; Vitamin B Complex | 2000 |
Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism.
Topics: Adult; Aged; Amino Acid Substitution; Cross-Sectional Studies; Electrophoresis, Capillary; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Regression Analysis; Riboflavin | 2000 |
Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study.
Topics: Adult; Aged; Diet; Dietary Fats; Fasting; Female; Folic Acid; Fruit; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Pyridoxal Phosphate; Vegetables; Vitamin B 12 | 2000 |
Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure?
Topics: Aged; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Erythrocytes; Female; Folic Acid; Hematinics; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitrites; Placebos; Prospective Studies; Renal Dialysis; Ultrasonography; Vasodilation; von Willebrand Factor | 2000 |
Increased plasma homocyst(e)ine after withdrawal of ready-to-eat breakfast cereal from the diet: prevention by breakfast cereal providing 200 microg folic acid.
Topics: Aged; Edible Grain; Female; Folic Acid; Food, Fortified; Heart Diseases; Homocysteine; Homocystine; Humans; Male; Middle Aged; Risk Factors; Vitamins | 2000 |
Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Sex Factors; Treatment Outcome; Vitamin B 12 | 2000 |
Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease.
Topics: Aged; Antioxidants; Ascorbic Acid; Blood Circulation; Coronary Disease; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Malondialdehyde; Middle Aged; Nitroglycerin; Vasodilation; Vasodilator Agents; Vitamin B 12; Vitamin E | 2000 |
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.
Topics: Aged; Aged, 80 and over; Dietary Supplements; DNA; DNA Methylation; DNA-Cytosine Methylases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Least-Squares Analysis; Leukocytes; Middle Aged; Nutrition Policy; S-Adenosylmethionine; Scintillation Counting; Statistics, Nonparametric | 2000 |
Homocysteine and venous thrombosis: outline of a vitamin intervention trial.
Topics: Adult; Aged; Aged, 80 and over; Comorbidity; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Male; Middle Aged; Netherlands; Prospective Studies; Pulmonary Embolism; Pyridoxine; Retrospective Studies; Secondary Prevention; Thrombophilia; Thrombophlebitis; Treatment Outcome; Ultrasonography; Venous Thrombosis; Vitamin B 12 | 2000 |
Second-trimester plasma homocysteine levels and pregnancy-induced hypertension, preeclampsia, and intrauterine growth restriction.
Topics: Adult; Erythrocytes; Female; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Hypertension; Osmolar Concentration; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, Second; Reference Values; Zinc | 2000 |
Low-dose folic acid supplementation reduces plasma levels of the cardiovascular risk factor homocysteine in postmenopausal women.
Topics: Cardiovascular Diseases; Dose-Response Relationship, Drug; Female; Folic Acid; Hematinics; Homocysteine; Humans; Middle Aged; Postmenopause; Risk Factors | 2000 |
HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia.
Topics: Adult; Aged; Ascorbic Acid; Beverages; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Citrus; Energy Intake; Female; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Male; Middle Aged; Nutritional Physiological Phenomena; Triglycerides | 2000 |
Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine.
Topics: Adult; Aged; Blood Glucose; Brachial Artery; Cholesterol; Cholesterol, HDL; Coronary Disease; Dietary Supplements; Double-Blind Method; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Nitroglycerin; Regression Analysis; Triglycerides; Ultrasonography; Vasodilator Agents; Vitamin B 12 | 2000 |
A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH).
Topics: Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Drug Therapy, Combination; Factor Analysis, Statistical; Female; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Placebos; Simvastatin; Triglycerides; Vitamin B 12 | 2000 |
Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children.
Topics: Adolescent; Aging; Chi-Square Distribution; Child; Child, Preschool; Chromatography, High Pressure Liquid; Fasting; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Radioimmunoassay; Vitamin B 12 | 2000 |
Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet.
Topics: Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Cerebrovascular Disorders; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Minerals; Nutritional Status; Pyridoxal Phosphate; Risk Factors; Vitamin B 12; Vitamin B Complex; Vitamins | 2000 |
Rapid communication: L-folinic acid versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Leucovorin; Male; Middle Aged; Renal Dialysis; Treatment Outcome | 2001 |
Plasma homocysteine concentrations in the acute and convalescent periods of atherothrombotic stroke.
Topics: Acute Disease; Adult; Aged; Arteriosclerosis; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Convalescence; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intracranial Thrombosis; Lipids; Male; Middle Aged; Regression Analysis; Risk Factors; Scotland; Stroke; Stroke Rehabilitation; Tomography, X-Ray Computed; Vitamin B 12 | 2001 |
Plasmatic homocysteine response to vitamin supplementation in elderly people.
Topics: Aged; Aged, 80 and over; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Vascular Diseases; Vitamins | 2000 |
Vitamin Intervention for Stroke Prevention (VISP) trial: rationale and design.
Topics: Adult; Aged; Cerebral Infarction; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Homocystine; Humans; Male; Middle Aged; Pyridoxine; Risk Factors; Vitamin B 12 | 2001 |
Homocysteine, fibrinogen, and lipoprotein(a) levels are simultaneously reduced in patients with chronic renal failure treated with folic acid, pyridoxine, and cyanocobalamin.
Topics: Adult; Arteriosclerosis; Cholesterol; Creatinine; Drug Therapy, Combination; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Lipoprotein(a); Male; Pyridoxine; Renal Dialysis; Risk Factors; Triglycerides; Urea; Uric Acid; Vitamin B 12; Vitamin B Complex | 2001 |
Oral vitamin B(12) and high-dose folic acid in hemodialysis patients with hyper-homocyst(e)inemia.
Topics: Administration, Oral; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Renal Dialysis; Vitamin B 12 | 2001 |
Randomized trial of folic acid supplementation and serum homocysteine levels.
Topics: Adult; Analysis of Variance; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Food, Fortified; Homocysteine; Humans; Myocardial Ischemia | 2001 |
Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans.
Topics: Adult; Cardiovascular Diseases; Chlorogenic Acid; Coffee; Cross-Over Studies; Fasting; Female; Flavonoids; Folic Acid; Glucosides; Homocysteine; Humans; Male; Phenols; Polymers; Postprandial Period; Pyridoxine; Quercetin; Risk Factors; Tea; Vitamin B 12 | 2001 |
Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Case-Control Studies; Double-Blind Method; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Polymorphism, Genetic; Prospective Studies | 2001 |
Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete.
Topics: Aged; Aged, 80 and over; Diet Records; Dietary Supplements; Double-Blind Method; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Pyridoxine; Riboflavin; Riboflavin Deficiency | 2001 |
Efficacy of folinic versus folic acid for the correction of hyperhomocysteinemia in hemodialysis patients.
Topics: Double-Blind Method; Drug Administration Schedule; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infusions, Intravenous; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Renal Dialysis; Treatment Outcome; Vitamin B 12 | 2001 |
Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older men.
Topics: Age Distribution; Aged; Case-Control Studies; Cohort Studies; Confidence Intervals; Finland; Folic Acid; Homocysteine; Humans; Incidence; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Pyridoxine; Reference Values; Risk Factors; Sampling Studies; Sensitivity and Specificity; Vitamin B 12 | 2001 |
Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia.
Topics: Abortion, Habitual; Adult; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Infant, Premature; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Pyridoxine; Vitamin E | 2001 |
High-dose simvastin (80 mg/day) decreases plasma concentrations of total homocyst(e)ine in patients with hypercholesteromia.
Topics: Cholesterol; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Prospective Studies; Simvastatin; Vitamin B 12 | 2001 |
Homocysteine lowering effect of different multivitamin preparations in patients with end-stage renal disease.
Topics: Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Pyridoxine; Renal Dialysis; Vitamin B 12 | 2001 |
Effects of growth hormone (GH) administration on homocyst(e)ine levels in men with GH deficiency: a randomized controlled trial.
Topics: Adult; Folic Acid; Growth Hormone; Homocysteine; Homocystine; Humans; Male; Middle Aged; Nutrition Assessment; Single-Blind Method; Thyroid Hormones; Time Factors; Vitamin B 12 | 2001 |
A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease.
Topics: Aged; Coronary Disease; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nitrates; Nitrites; Regional Blood Flow; von Willebrand Factor | 2001 |
Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine.
Topics: Aged; Attention; Biomarkers; Cognition Disorders; Dementia; Female; Folic Acid; Homocysteine; Humans; Male; Memory; Mental Status Schedule; Vitamin B 12 | 2001 |
Homocyst(e)ine metabolism in hemodialysis patients treated with vitamins B6, B12 and folate.
Topics: Female; Folic Acid; Hematinics; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pyridoxine; Regression Analysis; Renal Dialysis; Vitamin B 12; Vitamin B Complex | 2001 |
Folic acid enrichment of bread does not appear to affect zinc absorption in young women.
Topics: Adult; Bread; Cross-Over Studies; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Intestinal Absorption; Neural Tube Defects; Zinc; Zinc Isotopes | 2001 |
Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?
Topics: Animals; Biopterins; Cells, Cultured; Coronary Disease; Cross-Over Studies; Cytoplasm; Dietary Supplements; Dilatation, Pathologic; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Injections, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Superoxides; Tetrahydrofolates | 2001 |
Homocysteine levels in patients treated with lipid apheresis: effect of a vitamin therapy.
Topics: Adult; Cystathionine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipoproteinemia Type II; Lipids; Male; Vitamin B 12; Vitamin B 6 | 2001 |
Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption.
Topics: Administration, Oral; Aged; Aged, 80 and over; Blood Cell Count; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nutrition Disorders; Prospective Studies; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate.
Topics: Cross-Over Studies; Double-Blind Method; Fenofibrate; Folic Acid; Homocysteine; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Pyridoxine; Vitamin B 12; Vitamins | 2001 |
Homocysteine metabolism and effects of folic acid supplementation in patients affected with spina bifida.
Topics: Administration, Oral; Adolescent; Adult; Case-Control Studies; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Middle Aged; Spinal Dysraphism; Treatment Outcome | 2000 |
Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol--a randomized controlled trial.
Topics: Adult; Aged; Cholesterol; Coffee; Dose-Response Relationship, Drug; Female; Filtration; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Risk Factors; Surveys and Questionnaires | 2001 |
Folate supplementation prevents plasma homocysteine increase after fenofibrate therapy.
Topics: Arteriosclerosis; Dietary Supplements; Drug Synergism; Drug Therapy, Combination; Fenofibrate; Folic Acid; Homocysteine; Humans; Hyperlipidemias; Hypolipidemic Agents; Pilot Projects; Risk Factors | 2001 |
Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study.
Topics: Acetylcholine; Adult; Blood Flow Velocity; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Enzyme Inhibitors; Folic Acid; Forearm; Heart Rate; Hematinics; Homocysteine; Humans; Infusion Pumps; Male; Nitric Oxide Synthase; Nitroglycerin; omega-N-Methylarginine; Vasodilator Agents | 2001 |
Pyridoxine improves endothelial function in cardiac transplant recipients.
Topics: Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Follow-Up Studies; Heart Transplantation; Homocysteine; Humans; Male; Methionine; Middle Aged; Pyridoxine | 2001 |
Folate supplementation in peritoneal dialysis patients with normal erythrocyte folate: effect on plasma homocysteine.
Topics: Anorexia; Depression; Down-Regulation; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Male; Middle Aged; Peritoneal Dialysis; Sleep Initiation and Maintenance Disorders; Vitamin B 12 | 2001 |
High vegetable and fruit diet intervention in premenopausal women with cervical intraepithelial neoplasia.
Topics: Adult; Carotenoids; Female; Folic Acid; Fruit; Health Promotion; Homocysteine; Humans; Middle Aged; Precancerous Conditions; Premenopause; Regression Analysis; Surveys and Questionnaires; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vegetables | 2001 |
Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviral therapy.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Antiretroviral Therapy, Highly Active; Biomarkers; Cystathionine; Cysteine; Fasting; Female; Folic Acid; HIV Infections; HIV-1; Homocysteine; Humans; Male; Methionine; Methylmalonic Acid; Middle Aged; Multivariate Analysis; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Sarcosine; Vitamin B 6 | 2001 |
Do folate induced changes in serum homocysteine affect leukocyte concentrations in patients with ischaemic heart disease?
Topics: Aged; Female; Folic Acid; Hematinics; Homocysteine; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Ischemia | 2001 |
Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Reference Values; Vascular Resistance | 2001 |
Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-contr
Topics: Adult; Blood Pressure; Brachial Artery; Carotid Arteries; Drug Therapy, Combination; Elasticity; Endothelium, Vascular; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Pyridoxine; Vasodilation | 2001 |
Decreased rate of coronary restenosis after lowering of plasma homocysteine levels.
Topics: Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coronary Vessels; Disease-Free Survival; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Pyridoxine; Vitamin B 12 | 2001 |
Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.
Topics: Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Middle Aged; Tetrahydrofolates; Time Factors; Treatment Outcome; Vasodilation | 2002 |
Vitamin B6 metabolism and homocysteine in end-stage renal disease and chronic renal insufficiency.
Topics: Aged; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pyridoxal Phosphate; Vitamin B 6 | 2002 |
[Effect of hypolipemic agents on levels of total plasma homocysteine].
Topics: Adolescent; Adult; Aged; Cholesterol; Female; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Male; Middle Aged; Pravastatin; Vitamin B 12; Vitamin B 6 | 2001 |
Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease.
Topics: Adult; Aged; Cardiovascular Diseases; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2002 |
The effect of folic acid supplementation on plasma homocysteine in an elderly population.
Topics: Aged; Cardiovascular Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Hematinics; Homocysteine; Humans; Linear Models; Male; Methylmalonic Acid | 2002 |
[A case-control study on the relationship between abnormal homocysteine metabolism and essential hypertension].
Topics: Adult; Aged; Case-Control Studies; China; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymorphism, Restriction Fragment Length; Risk Factors; Vitamin B 12 | 2000 |
Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid-fortified cereal grain flour.
Topics: Coronary Artery Disease; Edible Grain; Female; Flour; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Riboflavin; Vitamin B 6 | 2002 |
Treatment of hyperhomocysteinemia with folic acid reduces oxidative stress in renal transplant recipients.
Topics: Adult; Antioxidants; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male; Oxidative Stress; Postoperative Complications; Time Factors | 2002 |
Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure?
Topics: Administration, Oral; Adolescent; Child; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Lipids; Male; Nitroglycerin; Oxidative Stress; Vasodilation; Vasodilator Agents; Vasomotor System | 2002 |
The effects of folate supplementation on some coagulation parameters and oxidative status surrogates.
Topics: Blood Coagulation; Blood Coagulation Disorders; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prospective Studies | 2002 |
Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Osmolar Concentration; Renal Dialysis; Vitamin B 12; Vitamin B 6 | 2002 |
Effect of treatment with folic acid and vitamin B6 on lipid and homocysteine concentrations in patients with coronary artery disease.
Topics: Aged; Coronary Artery Disease; Dietary Supplements; Female; Folic Acid; Genotype; Hematinics; Homocysteine; Humans; Lipids; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prospective Studies; Treatment Outcome; Vitamin B 6 | 2002 |
Nutritional advice to increase soluble fibre intake does not change plasma folate or homocysteine in men with angina: a randomised controlled trial.
Topics: Aged; Angina Pectoris; Dietary Fiber; Folic Acid; Fruit; Genotype; Hematinics; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Smoking; Solubility; Vegetables | 2002 |
Randomized trial of methylcobalamin and folate effects on homocysteine in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Prospective Studies; Renal Dialysis; Vitamin B 12 | 2002 |
Effect of folic acid and vitamin C supplementation on folate status and homocysteine level: a randomised controlled trial in Italian smoker-blood donors.
Topics: Adult; Ascorbic Acid; Blood Donors; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Italy; Male; Middle Aged; Probability; Prospective Studies; Reference Values; Sensitivity and Specificity; Smoking; Statistics, Nonparametric | 2002 |
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Daunorubicin; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Linear Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation | 2002 |
Unexpected inverse relationship between insulin resistance and serum homocysteine in healthy subjects.
Topics: Age Factors; Blood Glucose; Body Mass Index; Cholesterol, HDL; Female; Folic Acid; Homocysteine; Hormones; Humans; Insulin Resistance; Male; Middle Aged; Octreotide; Plasminogen Activator Inhibitor 1; Regression Analysis; Risk Factors; Sex Factors | 2002 |
Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Hyperhomocysteinemia; Injections, Subcutaneous; Kidney Failure, Chronic; Male; Methylmalonic Acid; Middle Aged; Prospective Studies; Renal Dialysis; Treatment Outcome; Vitamin B 12 | 2002 |
Methylenetetrahydrofolate reductase 677C-->T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial.
Topics: Adult; Diet; Dietary Supplements; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Nutrition Assessment; Oxidoreductases Acting on CH-NH Group Donors; Patient Compliance; Placebos | 2002 |
Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial.
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Double-Blind Method; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Neural Tube Defects; Nutritional Requirements; Placebos; Vitamin B 12 | 2002 |
Effect of supplementation with folic-acid on relation between plasma homocysteine, folate, and vitamin B12.
Topics: Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Vitamin B 12 | 2002 |
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.
Topics: Adult; Analysis of Variance; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Requirements; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Riboflavin | 2002 |
Reduction of plasma homocysteine by folic acid in children with chronic renal failure.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Kidney Failure, Chronic; Male | 2002 |
Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial.
Topics: Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Stenosis; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2002 |
Effect of homocysteine reduction by B-vitamin supplementation on markers of clotting activation.
Topics: Adult; Aged; Antithrombin III; Biomarkers; Blood Coagulation; Dietary Supplements; Female; Fibrin Fibrinogen Degradation Products; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Male; Middle Aged; Peptide Fragments; Peptide Hydrolases; Prothrombin; Pyridoxine; Vitamin B Complex | 2002 |
Fiber-multivitamin combination therapy: a beneficial influence on low-density lipoprotein and homocysteine.
Topics: Adult; Blood Glucose; Cholesterol, LDL; Dietary Fiber; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Lipoproteins, LDL; Male; Middle Aged; Triglycerides; Vitamin B Complex; Vitamins | 2002 |
Effects of folic acid and vitamin B12 supplements on folate and homocysteine metabolism in pigs during early pregnancy.
Topics: Animal Nutritional Physiological Phenomena; Animals; Dietary Supplements; Female; Folic Acid; Homocysteine; Parity; Pregnancy; Pregnancy, Animal; Swine; Uterus; Vitamin B 12 | 2002 |
Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status.
Topics: Aged; Analysis of Variance; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Northern Ireland; Photosensitizing Agents; Riboflavin; Riboflavin Deficiency; Vitamin B 12 | 2002 |
Effects of folate treatment and homocysteine lowering on resistance vessel reactivity in atherosclerotic subjects.
Topics: Arteriosclerosis; Blood Flow Velocity; Cholesterol; Coronary Disease; Cross-Over Studies; Folic Acid; Forearm; Homocysteine; Humans; Male; Middle Aged; Placebos; Regional Blood Flow; Triglycerides; Vascular Resistance; Vitamin B 12 | 2002 |
Effect of folic acid therapy on serum homocysteine level in renal transplant recipients.
Topics: Adult; Creatinine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male | 2002 |
Dietary counseling to increase natural folate intake: a randomized, placebo-controlled trial in free-living subjects to assess effects on serum folate and plasma total homocysteine.
Topics: Aged; Counseling; Diet; Edible Grain; Energy Intake; Female; Folic Acid; Fruit; Homocysteine; Humans; Male; Middle Aged; New Zealand; Nuts; Placebos; Seeds; Vegetables | 2002 |
Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age.
Topics: Adult; Cross-Sectional Studies; Double-Blind Method; Female; Folic Acid; Hematinics; Homocysteine; Humans; Patient Selection; Software Design; Treatment Outcome | 2002 |
Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Australia; Biomarkers; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Hematinics; Homocysteine; Humans; Male; Middle Aged; New Zealand; Pyridines; Thiazepines; Time Factors; Treatment Outcome | 2002 |
The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs.
Topics: Adult; Anticonvulsants; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epilepsy; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Methionine; Middle Aged; Pyridoxic Acid; Riboflavin; Selectins; Vascular Cell Adhesion Molecule-1; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2002 |
Homocysteine, cysteine, and B vitamins as predictors of kidney disease progression.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Biomarkers; Blood Pressure Monitoring, Ambulatory; Cysteine; Diet, Protein-Restricted; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Male; Middle Aged; Prognosis; Pyridoxal Phosphate; Risk Factors; Vitamin B 12 | 2002 |
Vitamin intervention for stroke prevention.
Topics: Aged; Diet; Double-Blind Method; Electrocardiography; Endpoint Determination; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Recurrence; Risk Factors; Stroke; Vitamin B 12; Vitamin B 6; Vitamins | 2002 |
Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation.
Topics: Adolescent; Adult; Dietary Supplements; Double-Blind Method; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B 12; Vitamin B 6 | 2002 |
Effect of protein and methionine intakes on plasma homocysteine concentrations: a 6-mo randomized controlled trial in overweight subjects.
Topics: Adolescent; Adult; Analysis of Variance; Body Weight; Diet; Diet, Protein-Restricted; Dietary Proteins; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Obesity; Vitamin B 12 | 2002 |
Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Forearm; Hematinics; Homocysteine; Humans; Male; Middle Aged; Regression Analysis; Smoking; Vascular Resistance; Vitamin B 12 | 2002 |
Functionality of endogenous folates from rye and orange juice using human in vivo model.
Topics: Adult; Aged; Beverages; Biological Availability; Citrus sinensis; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Secale | 2002 |
Study of wheat breakfast rolls fortified with folic acid. The effect on folate status in women during a 3-month intervention.
Topics: Adult; Biological Availability; Bread; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Erythrocytes; Female; Folic Acid; Food Handling; Food, Fortified; Homocysteine; Humans; Middle Aged; Neural Tube Defects; Nutritional Status; Triticum | 2002 |
Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype.
Topics: Adolescent; Adult; Aged; Dietary Supplements; Endothelium, Vascular; Erythrocytes; Female; Folic Acid; Genotype; Glutathione Reductase; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Regression Analysis; Riboflavin | 2003 |
Capecitabine treatment results in increased mean corpuscular volume of red blood cells in patients with advanced solid malignancies.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Erythrocyte Indices; Erythrocytes; Female; Fluorouracil; Folic Acid; Hematinics; Homocysteine; Humans; Male; Middle Aged; Neoplasms; Prospective Studies; Retrospective Studies; Thymidylate Synthase; Vitamin B 12 | 2003 |
A comparison of the effect of advice to eat either '5-a-day' fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine.
Topics: Adolescent; Adult; Aged; Diet Records; Female; Folic Acid; Food, Fortified; Fruit; Homocysteine; Humans; Male; Middle Aged; Nutrition Policy; Reference Values; United Kingdom; Vegetables | 2003 |
Effects of acute hyperhomocysteinemia on the neurovascular coupling mechanism in healthy young adults.
Topics: Acute Disease; Adult; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cross-Over Studies; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Photic Stimulation; Posterior Cerebral Artery; Reference Values; Systole; Ultrasonography, Doppler, Transcranial | 2003 |
Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study.
Topics: Adult; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Neural Tube Defects; Placebos; Tetrahydrofolates; Treatment Outcome; Vitamin B 12 Deficiency | 2003 |
Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage.
Topics: Adult; Aged; Antioxidants; Cardiovascular Diseases; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Glutathione Peroxidase; Homocysteine; Humans; Male; Malondialdehyde; Middle Aged; Nutritional Status; Oxidation-Reduction; Reactive Oxygen Species; Risk Factors; Single-Blind Method; Superoxide Dismutase | 2003 |
Folic acid treatment reduces elevated plasma levels of asymmetric dimethylarginine in hyperhomocysteinaemic subjects.
Topics: Adult; Aged; Arginine; Biomarkers; Dietary Supplements; Enzyme Inhibitors; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase | 2003 |
Antihypertensive treatment and homocysteine concentrations.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Cardiovascular Diseases; Creatinine; Cystatin C; Cystatins; Female; Folic Acid; Homocysteine; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prospective Studies; Risk Factors; Vitamin B 12; Vitamin B 6 | 2003 |
Weekly high-dose folic Acid supplementation is effective in lowering serum homocysteine concentrations in women.
Topics: Adolescent; Adult; Dietary Supplements; Double-Blind Method; Drug Administration Schedule; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Treatment Outcome | 2003 |
The effect of vitamin B12 on total plasma homocysteine concentration in folate-replete hemodialysis patients.
Topics: Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylmalonic Acid; Middle Aged; Renal Dialysis; Statistics, Nonparametric; Treatment Outcome; Vitamin B 12 | 2003 |
Can black tea influence plasma total homocysteine concentrations?
Topics: Adult; Aged; Blood Pressure; Body Mass Index; Cholesterol; Cross-Over Studies; Female; Flavonoids; Folic Acid; Gallic Acid; Homocysteine; Humans; Lipids; Male; Methylation; Middle Aged; Phenols; Polymers; Polyphenols; Tea; Vitamin B 12; Vitamin B 6 | 2003 |
Folate catabolite excretion is responsive to changes in dietary folate intake in elderly women.
Topics: 4-Aminobenzoic Acid; Aged; Aged, 80 and over; Aging; Diet; DNA Methylation; Erythrocytes; Female; Folic Acid; Glutamates; Homocysteine; Humans; Kinetics; Middle Aged; Nutritional Status; para-Aminobenzoates | 2003 |
Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status.
Topics: Antiparkinson Agents; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Linear Models; Male; Middle Aged; Parkinson Disease; Pyridoxal Phosphate; Risk Factors; Vitamin B 12; Vitamin B Complex | 2003 |
Plasma homocysteine concentration is decreased by dietary intervention.
Topics: Adult; Cross-Over Studies; Diet; Erythrocytes; Female; Folic Acid; Fruit; Homocysteine; Humans; Middle Aged; Vegetables; Vitamin B 12 | 2003 |
Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study.
Topics: Aged; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Regression Analysis | 2003 |
Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Androstane-3,17-diol; Biomarkers; C-Reactive Protein; Creatinine; Cyproterone Acetate; Cysteine; Estradiol; Estrogens; Female; Fibrinogen; Folic Acid; Follicle Stimulating Hormone; Homocysteine; Humans; Luteinizing Hormone; Male; Middle Aged; Randomized Controlled Trials as Topic; Serum Albumin; Statistics as Topic; Testosterone; Time Factors; Transsexualism | 2003 |
Effect of homocysteine-lowering therapy on restenosis after percutaneous coronary intervention for narrowings in small coronary arteries.
Topics: Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Prospective Studies; Stents; Vitamin B 12; Vitamin B 6 | 2003 |
Secondary prevention with folic acid: effects on clinical outcomes.
Topics: Aged; Cholesterol; Coronary Artery Disease; Drug Therapy, Combination; Endothelium, Vascular; Female; Folic Acid; Follow-Up Studies; Hematinics; Homocysteine; Humans; Hypolipidemic Agents; Lipids; Male; Middle Aged; Outcome Assessment, Health Care; Time Factors; Triglycerides | 2003 |
Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia.
Topics: Aged; Aged, 80 and over; Aspirin; Cognition Disorders; Dementia; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Isoprostanes; Male; Middle Aged; Oxidative Stress; Platelet Activation; Platelet Aggregation Inhibitors; Riboflavin; Thromboxanes; Vitamin B 12; Vitamins | 2003 |
A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men.
Topics: Adult; Antioxidants; Blood Glucose; Cross-Over Studies; Double-Blind Method; Folic Acid; Fruit; Homocysteine; Humans; Insulin; Male; Vegetables | 2003 |
Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration.
Topics: Aged; Anticholesteremic Agents; Cross-Over Studies; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fluvastatin; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Hypolipidemic Agents; Indoles; Male; Middle Aged; Prospective Studies | 2003 |
Effect of folic acid on fenofibrate-induced elevation of homocysteine and cysteine.
Topics: Cholesterol; Creatinine; Cysteine; Female; Fenofibrate; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Prospective Studies; Statistics as Topic; Triglycerides; Uric Acid | 2003 |
Effects of folic acid supplementation on inflammatory and thrombogenic markers in chronic smokers. A randomised controlled trial.
Topics: Adult; Biomarkers; Blood Proteins; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Folic Acid; Homocysteine; Humans; Inflammation; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Smoking; Thrombophilia; Treatment Outcome | 2003 |
Influence of anticalcineurinic therapy in plasma homocysteine levels of renal transplant recipients: a prospective study.
Topics: Adult; Calcineurin Inhibitors; Creatinine; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Kidney Transplantation; Male; Middle Aged; Regression Analysis; Time Factors; Vitamin B 12 | 2003 |
Treatment of hyperhomocysteinemia after renal transplantation.
Topics: Adult; Aged; Creatinine; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Reproducibility of Results; Safety; Time Factors; Vitamin B 12 | 2003 |
Folic acid supplementation in dementia: a preliminary report.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Neuropsychological Tests; Prevalence; Risk Factors | 2003 |
Homocysteine and its relation to B-vitamins in Graves' disease before and after treatment: effect modification by smoking.
Topics: Adolescent; Adult; Aged; Antithyroid Agents; Carbimazole; Creatinine; Female; Folic Acid; Graves Disease; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Regression Analysis; Riboflavin; Smoking; Vitamin B 12; Vitamin B Complex | 2003 |
Plasma total homocysteine in Mexican rural and urban women fed typical model diets.
Topics: Adolescent; Adult; Cross-Over Studies; Diet; Fasting; Female; Folic Acid; Homocysteine; Humans; Methionine; Mexico; Middle Aged; Nutritional Status; Reference Values; Rural Health; Urban Health; Vitamin B 12 | 2003 |
Folic acid supplement decreases the homocysteine increasing effect of filtered coffee. A randomised placebo-controlled study.
Topics: Adult; Aged; Coffee; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Placebos; Pyridoxine | 2003 |
Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: a randomised trial.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Acid; Reference Values; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2003 |
Folic acid and vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patients.
Topics: Adult; Antioxidants; Diagnostic Techniques and Procedures; Dietary Supplements; Drug Administration Schedule; Endothelium, Vascular; Female; Folic Acid; Gene Frequency; Genetic Markers; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Pharmacology, Clinical; Uric Acid; Vasodilation; Vitamin E | 2004 |
Background and rationale of the SU.FOL.OM3 study: double-blind randomized placebo-controlled secondary prevention trial to test the impact of supplementation with folate, vitamin B6 and B12 and/or omega-3 fatty acids on the prevention of recurrent ischemi
Topics: Aged; Aged, 80 and over; Coronary Artery Disease; Dietary Supplements; Double-Blind Method; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Humans; Intracranial Arteriosclerosis; Ischemia; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Vitamin B 12; Vitamin B 6 | 2003 |
Measurement of carotid plaque and effect of vitamin therapy for total homocysteine.
Topics: Aged; Carotid Stenosis; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Imaging, Three-Dimensional; Reproducibility of Results; Stroke; Ultrasonography; Vitamin B 12; Vitamin B 6; Vitamins | 2003 |
Folate improves endothelial function in patients with coronary heart disease.
Topics: Administration, Oral; Brachial Artery; Coronary Disease; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Regional Blood Flow; Tetrahydrofolates; Vasodilation | 2003 |
Randomized, placebo-controlled trial of intramuscular vitamin B12 for the treatment of hyperhomocysteinaemia in dialysis patients.
Topics: Adult; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intramuscular; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Renal Dialysis; Vitamin B 12 | 2003 |
Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Betaine; Choline; Coronary Angiography; Dietary Supplements; Drug Administration Schedule; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methionine; Methyltransferases; Middle Aged; Sarcosine; Sex Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2004 |
Lipid, glucose and homocysteine metabolism in women treated with a GnRH agonist with or without raloxifene.
Topics: Adult; Blood Glucose; Body Constitution; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Delayed-Action Preparations; Female; Folic Acid; Homeostasis; Homocysteine; Humans; Insulin; Insulin Resistance; Leiomyoma; Leuprolide; Lipids; Middle Aged; Placebos; Premenopause; Raloxifene Hydrochloride; Triglycerides; Uterine Neoplasms; Vitamin B 12 | 2004 |
Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease.
Topics: Cardiovascular Diseases; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged | 2004 |
Mineral water fortified with folic acid, vitamins B6, B12, D and calcium improves folate status and decreases plasma homocysteine concentration in men and women.
Topics: Adult; Blood Pressure; Calcium, Dietary; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Mineral Waters; Vitamin B Complex; Vitamin D | 2004 |
Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial.
Topics: Adult; Aged; Coronary Disease; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Recurrence; Risk; Stroke; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2004 |
Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals.
Topics: Adult; Aged; Apolipoproteins B; Beverages; Cholesterol; Cholesterol, LDL; Citrus; Double-Blind Method; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hypercholesterolemia; Male; Middle Aged; Phytosterols; Sitosterols; Stigmasterol; Treatment Outcome; Vitamin B 12 | 2004 |
Effect of homocysteine-lowering vitamin treatment on electrocardiography stress tests in a randomized, placebo-controlled trial: comparison between ST-segment changes and Athen QRS-score.
Topics: Coronary Artery Disease; Double-Blind Method; Electrocardiography; Exercise Test; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Vitamin B 6 | 2004 |
Bioavailability of heptaglutamyl relative to monoglutamyl folic acid in healthy adults.
Topics: Administration, Oral; Aged; Biological Availability; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Intestinal Absorption; Male; Middle Aged; Pteroylpolyglutamic Acids | 2004 |
Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.
Topics: Adult; Analysis of Variance; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Placebos; Tetrahydrofolates; Treatment Outcome; Vitamin B 12 Deficiency | 2004 |
Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Mental Recall; Middle Aged; Single-Blind Method; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2004 |
The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men.
Topics: Adult; Biological Availability; Cross-Over Studies; Diet; Double-Blind Method; Energy Intake; Folic Acid; Genotype; Homocysteine; Humans; Kinetics; Male; Methylenetetrahydrofolate Reductase (NADPH2); Tetrahydrofolates; Time Factors; Vitamin B 12 | 2004 |
Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users.
Topics: Adult; Contraceptives, Oral; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Risk Assessment; Thromboembolism; Vitamin B 12; Vitamin B 6 | 2003 |
Gene-nutrient and gene-gene interactions of controlled folate intake by Japanese women.
Topics: Adult; Cardiovascular Diseases; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Homocysteine; Humans; Japan; Methylenetetrahydrofolate Reductase (NADPH2); Women's Health | 2004 |
Effects of folic acid fortification and multivitamin therapy on homocysteine and vitamin B(12) status in cardiac transplant recipients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Canada; Cohort Studies; Dietary Supplements; Female; Ferredoxin-NADP Reductase; Folic Acid; Food, Fortified; Heart Transplantation; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Middle Aged; Polymorphism, Single Nucleotide; Vitamin B 12; Vitamins | 2004 |
Effect of homocysteine-lowering treatment with folic acid plus vitamin B on cerebrovascular atherosclerosis and white matter abnormalities as determined by MRA and MRI: a placebo-controlled, randomized trial.
Topics: Adult; Arteriosclerosis; Biomarkers; Cerebrovascular Circulation; Cross-Over Studies; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Risk Factors; Treatment Outcome; Vitamin B 6 | 2004 |
Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial.
Topics: Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Double-Blind Method; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methionine; Middle Aged; Vitamin B 12; Vitamin B 6 | 2004 |
Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Prospective Studies; Renal Dialysis; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2004 |
Effects of moderate alcohol consumption on folate and vitamin B(12) status in postmenopausal women.
Topics: Aged; Alcohol Drinking; Cross-Over Studies; DNA Methylation; Dose-Response Relationship, Drug; Ethanol; Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Nutritional Status; Postmenopause; Vitamin B 12 | 2004 |
The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study.
Topics: Adult; Coffee; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymorphism, Genetic | 2004 |
[Study of the effect of medicinal product "STRESSEN" on blood levels of homocysteine in patients with current cardiovascular disease].
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Drug Combinations; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Vitamin B 12 | 2004 |
[Comparison of treatment with STRESSEN and arginine glutamate on homocysteine blood levels].
Topics: Dipeptides; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Single-Blind Method; Vitamin B 12 | 2004 |
Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia.
Topics: Aged; Animals; Antioxidants; Cardiovascular Diseases; Fatty Acids, Omega-3; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperlipidemias; Lipids; Male; Malondialdehyde; Middle Aged; Milk; Oleic Acid; Risk Factors; Spain; Time Factors; Vascular Cell Adhesion Molecule-1; Vitamin B 6; Vitamin B Complex; Vitamin E | 2004 |
Folate therapy and in-stent restenosis after coronary stenting.
Topics: Aged; Coronary Angiography; Coronary Disease; Coronary Restenosis; Coronary Vessels; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Stents; Treatment Failure; Vitamin B 12; Vitamin B 6 | 2004 |
Ethnicity and race influence the folate status response to controlled folate intakes in young women.
Topics: Adult; Diet; Ethnicity; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Policy; Nutritional Status; Racial Groups | 2004 |
The effect of oral folic acid on glutathione, glycaemia and lipids in Type 2 diabetes.
Topics: Adult; Aged; Albuminuria; Blood Glucose; Blood Pressure; Cholesterol, HDL; Diabetes Mellitus, Type 2; Dietary Supplements; Erythrocytes; Female; Folic Acid; Glutathione; Glycated Hemoglobin; Homocysteine; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Triglycerides; Vitamin B 6 | 2004 |
Effect of folic Acid supplementation on the folate status of buccal mucosa and lymphocytes.
Topics: Adolescent; Adult; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Lymphocytes; Male; Middle Aged; Mouth Mucosa; Tetrahydrofolates | 2004 |
Effect of supplementation with folic acid throughout pregnancy on plasma homocysteine concentration.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Longitudinal Studies; Neural Tube Defects; Pregnancy; Treatment Outcome | 2004 |
Absence of macrocytic anaemia in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anemia, Macrocytic; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Male; Platelet Count; Sex Factors; Vitamin B 12 | 2004 |
Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Geriatric Assessment; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Minerals; Risk Assessment; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamins | 2005 |
Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Cardiovascular Diseases; Cystathionine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Norway; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2004 |
Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene.
Topics: Administration, Oral; Aged; Antigens, Surface; Biological Availability; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Gene Expression Regulation; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Intestinal Absorption; Male; Middle Aged; Pteroylpolyglutamic Acids | 2004 |
Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Lithium; Male; Probability; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Vitamin B 12 | 2004 |
Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapy.
Topics: Adult; Ambulatory Care; Depressive Disorder; Drug Administration Schedule; Female; Fluoxetine; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Probability; Psychiatric Status Rating Scales; Recurrence; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Vitamin B 12 | 2004 |
Plasma homocysteine levels after hormone therapy with and without folic acid supplementation: a randomized study.
Topics: Adult; Dietary Supplements; Estradiol; Estrogen Replacement Therapy; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Postmenopause | 2004 |
Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adults.
Topics: Aged; Aged, 80 and over; Brachial Artery; Dietary Supplements; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Prospective Studies; Single-Blind Method; Vasodilation; Vitamin B 12; Vitamin B 6; Vitamins | 2004 |
Effects of levodopa and COMT inhibitors on plasma homocysteine in Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Case-Control Studies; Catechols; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Levodopa; Linear Models; Male; Middle Aged; Nitriles; Parkinson Disease; Vitamin B 12 | 2005 |
Determining bioavailability of food folates in a controlled intervention study.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Spinacia oleracea; Tablets; Yeasts | 2004 |
Hormone replacement influences homocysteine levels in the methionine-loading test: a randomized placebo controlled trial in postmenopausal women.
Topics: Analysis of Variance; Blood Chemical Analysis; Double-Blind Method; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Female; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Postmenopause; Pyridoxine; Treatment Outcome; Vitamin B 12 | 2004 |
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia.
Topics: Aged; Drug Therapy, Combination; Endothelium, Vascular; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperinsulinism; Male; Metabolic Syndrome; Risk Factors; Vitamin B 12 | 2004 |
Creatine supplementation does not decrease total plasma homocysteine in chronic hemodialysis patients.
Topics: Aged; Aged, 80 and over; Creatine; Cross-Over Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Nutrition Assessment; Renal Dialysis; Vitamin B 12; Vitamin B 6 | 2004 |
Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy o
Topics: Biomarkers; Blood Coagulation; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Inflammation; Ischemic Attack, Transient; Pyridoxine; Risk Factors; Stroke; Vitamin B 12; Vitamin B Complex | 2005 |
Effect of cow milk on food folate bioavailability in young women.
Topics: Adult; Animals; Biological Availability; Cattle; Diet; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Intestinal Absorption; Milk | 2004 |
Sustained homocysteine-lowering effect over time of folic acid-based multivitamin therapy in stroke patients despite increasing folate status in the population.
Topics: Aged; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Hematinics; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Stroke; Time Factors; Vitamin B 12 | 2005 |
Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study.
Topics: Adult; Anovulation; Blood Glucose; Body Weight; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Insulin Resistance; Lipids; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Rosiglitazone; Testosterone; Thiazolidinediones; Vitamin B 12 | 2005 |
[Blood concentration of homocysteine, vitamin B (12), and folic acid in patients with exudative age related macular degeneration].
Topics: Aged; Erythrocytes; Folic Acid; Homocysteine; Humans; Macular Degeneration; Vitamin B 12 | 2004 |
Effect of antihypertensive treatment with candesartan or amlodipine on glutathione and its redox status, homocysteine and vitamin concentrations in patients with essential hypertension.
Topics: Amlodipine; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Humans; Hypertension; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Tetrazoles; Vitamin B 12 | 2005 |
S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study.
Topics: Aged; Brachial Artery; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nitroglycerin; Regional Blood Flow; Risk Factors; S-Adenosylmethionine; Tetrahydrofolates; Ultrasonography; Vasodilation; Vasodilator Agents; Vitamin B 12; Vitamin B 6 | 2005 |
The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia.
Topics: Adult; Aged; Antioxidants; Biomarkers; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress | 2005 |
Plasma homocysteine levels in Parkinson's disease: role of antiparkinsonian medications.
Topics: Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Dopamine Agonists; Enzyme Inhibitors; Female; Folic Acid; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Vitamin B 12 | 2005 |
Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial.
Topics: Aged; Bone Density; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Hemiplegia; Hip Fractures; Homocysteine; Humans; Male; Risk Factors; Stroke; Vitamin B 12 | 2005 |
Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes.
Topics: Acetylcholine; Administration, Oral; Blood Flow Velocity; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Endothelium, Vascular; Female; Folic Acid; Forearm; Homocysteine; Humans; Male; Middle Aged; Osmolar Concentration; Pulse; Regional Blood Flow; Vasodilation; Vasodilator Agents | 2005 |
Anti-heparan sulphate antibodies and homocysteine in dementia: markers of vascular pathology?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies; Biomarkers; Dementia, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Heparitin Sulfate; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2005 |
Intranasal 17beta-estradiol treatment and Vitamin B12, folate and homocysteine in menopause.
Topics: Administration, Intranasal; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Estradiol; Estrogen Replacement Therapy; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Postmenopause; Prospective Studies; Treatment Outcome; Triglycerides; Vitamin B 12 | 2005 |
Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial.
Topics: Adolescent; Adult; Blood Glucose; Body Weight; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Lipids; Menstrual Cycle; Metformin; Ovulation; Polycystic Ovary Syndrome; Vitamin B Complex | 2005 |
Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women.
Topics: Adult; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Obesity; Taiwan; Weight Loss | 2005 |
Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma.
Topics: Adenoma; Aged; Colorectal Neoplasms; Dietary Supplements; DNA Methylation; DNA, Neoplasm; Double-Blind Method; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Leukocytes; Male; Middle Aged; Rectum | 2005 |
[Hyperhomocysteinemia and treatment with antiepileptic drugs. Effects of different doses of folic acid].
Topics: Adult; Aged; Anticonvulsants; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged | 2005 |
Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study.
Topics: Adult; Aged; Amino Acids; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Urinary Tract Infections; Vitamin B 12; Vitamin B 6 | 2005 |
Aleurone flour increases red-cell folate and lowers plasma homocyst(e)ine substantially in man.
Topics: Adult; Aged; Bread; Diet; Erythrocytes; Female; Flour; Folic Acid; Food Handling; Homocysteine; Humans; Male; Middle Aged; Triticum | 2005 |
The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Vitamin B 12 | 2005 |
Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study.
Topics: Aged; Cognition; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Geriatrics; Homocysteine; Humans; Locomotion; Male; Methylmalonic Acid; Psychomotor Performance; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamin B Complex | 2005 |
Assessment of tailor-made prevention of atherosclerosis with folic acid supplementation: randomized, double-blind, placebo-controlled trials in each MTHFR C677T genotype.
Topics: Alleles; Arteriosclerosis; Dietary Supplements; Double-Blind Method; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation | 2005 |
L-folic acid supplementation in healthy postmenopausal women: effect on homocysteine and glycolipid metabolism.
Topics: Blood Glucose; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Cysteine; Energy Metabolism; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Insulin; Middle Aged; Postmenopause; Risk Factors; Risk Reduction Behavior | 2005 |
Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans.
Topics: Adult; Aged; Betaine; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Lipids; Lipotropic Agents; Male; Middle Aged; Phosphatidylcholines; Placebos; Risk Factors | 2005 |
Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age.
Topics: Adolescent; Adult; Animals; Biological Availability; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Middle Aged; Milk; Neural Tube Defects; Nutritional Status | 2005 |
Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans.
Topics: Adolescent; Adult; Animals; Biological Availability; Carrier Proteins; Double-Blind Method; Erythrocytes; Female; Folate Receptors, GPI-Anchored; Folic Acid; Food Handling; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Milk; Neural Tube Defects; Receptors, Cell Surface | 2005 |
Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12.
Topics: Aged; Brain Ischemia; Carotid Arteries; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography; Vitamin B 12; Vitamin B 6 | 2005 |
Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations.
Topics: Administration, Oral; Aged; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Fasting; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methionine; Methylation; Middle Aged | 2005 |
Effect of lowering of homocysteine levels on inflammatory markers: a randomized controlled trial.
Topics: Aged; Autoantibodies; C-Reactive Protein; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Hematinics; Homocysteine; Humans; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Male; Middle Aged | 2005 |
Plasma homocysteine and markers for oxidative stress and inflammation in patients with coronary artery disease--a prospective randomized study of vitamin supplementation.
Topics: Aged; Biomarkers; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Pyridoxine; Vitamin B 12; Vitamins | 2005 |
[Efficacy and safety of two vitamin supplement regimens on homocysteine levels in hemodialysis patients. Prospective, randomized clinical trial].
Topics: Aged; Aged, 80 and over; Cohort Studies; Diabetic Nephropathies; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Prospective Studies; Renal Dialysis; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2005 |
Homocysteine-lowering therapy and early progression of transplant vasculopathy: a prospective, randomized, IVUS-based study.
Topics: Adult; Cytomegalovirus Infections; Disease Progression; Female; Folic Acid; Heart Diseases; Heart Transplantation; Homocysteine; Humans; Hyperhomocysteinemia; Hyperplasia; Male; Middle Aged; Prospective Studies; Research Design; Risk Factors; Tetrahydrofolates; Time Factors; Ultrasonography; Vascular Diseases | 2005 |
No effect of folic acid supplementation in the course of 1 year on haemostasis markers and C-reactive protein in older adults.
Topics: Aged; C-Reactive Protein; Cardiovascular Diseases; Dietary Supplements; Factor VIIa; Female; Fibrin; Folic Acid; Hemostasis; Homocysteine; Humans; Inflammation; Male; Middle Aged; Placebos; Risk; Thromboplastin; Time Factors; von Willebrand Factor | 2005 |
[6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults.
Topics: Adult; Aging; Area Under Curve; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Intestinal Absorption; Male; Middle Aged; Tetrahydrofolates | 2005 |
Hyperhomocysteinemia in children treated with antiepileptic drugs is normalized by folic acid supplementation.
Topics: Anticonvulsants; Child; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Treatment Outcome; Vitamin B 12 | 2005 |
Effect of folic acid supplementation on mood and serotonin response in healthy males.
Topics: Adult; Affect; Analysis of Variance; Biomarkers; Diet Records; Dietary Supplements; Double-Blind Method; Erythrocytes; Folic Acid; Homocysteine; Humans; Male; Serotonin; Treatment Failure | 2005 |
Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy.
Topics: Adult; Analysis of Variance; Anemia, Iron-Deficiency; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Iron, Dietary; Korea; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Prenatal Nutritional Physiological Phenomena; Time Factors | 2005 |
Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease.
Topics: Aged; Analysis of Variance; Cognition; Double-Blind Method; Drug Synergism; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Male; Riboflavin; Treatment Outcome; Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamin B Complex; von Willebrand Factor | 2005 |
Folate co-administration improves the effectiveness of fenofibrate to decrease the lipoprotein oxidation and endothelial dysfunction surrogates.
Topics: Adult; Aged; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Drug Therapy, Combination; Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fluvastatin; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Hypolipidemic Agents; Indoles; Lipoproteins, LDL; Male; Malondialdehyde; Middle Aged; Prospective Studies; Thrombomodulin; Treatment Outcome; Triglycerides; Vitamin B Complex; von Willebrand Factor | 2006 |
Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia.
Topics: Aged; Dietary Supplements; Double-Blind Method; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Placebos; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2006 |
Preliminary results of the effect of treatment of hyperhomocysteinemia and its relationship with inflammation, coagulation status, and endothelial function after renal transplantation.
Topics: Adult; Aged; Biomarkers; Blood Coagulation; Blood Coagulation Disorders; Brachial Artery; Creatinine; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prospective Studies; Vitamin B 12 | 2005 |
Determining factors of the response to hyperhomocysteinemia treatment in renal transplant patients.
Topics: Adult; Aged; Analysis of Variance; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; ROC Curve; Treatment Outcome; Vitamin B 12 | 2005 |
The effect of postmenopausal hormone therapy with or without folic acid supplementation on serum homocysteine level.
Topics: Administration, Oral; Analysis of Variance; Contraceptive Agents, Female; Drug Therapy, Combination; Estradiol; Estrogen Replacement Therapy; Estrogens; Estrogens, Conjugated (USP); Female; Fluorescence Polarization; Folic Acid; Hematinics; Homocysteine; Humans; Medroxyprogesterone Acetate; Middle Aged; Postmenopause; Vitamin B 12 | 2005 |
Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes.
Topics: Aged; Female; Folic Acid; Genotype; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Renal Dialysis; Vitamin B 12; Vitamin B Complex | 2006 |
Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects.
Topics: Adult; Alanine Transaminase; Dietary Supplements; Double-Blind Method; Drug Interactions; Erythrocytes; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Riboflavin; Vitamin B Complex | 2006 |
Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients.
Topics: Aged; Coronary Artery Disease; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Ischemic Attack, Transient; Male; Methylenetetrahydrofolate Dehydrogenase (NAD+); Middle Aged; Models, Statistical; Placebos; Polymorphism, Genetic; Regression Analysis; Risk Factors; Singapore; Stroke; Vitamin B 12; Vitamin B 6; Vitamins | 2006 |
Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia.
Topics: Adult; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Pyridoxine; Schizophrenia; Schizophrenic Psychology; Time Factors; Vitamin B 12; Vitamin B Complex | 2006 |
Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial.
Topics: Aged; Cardiovascular Diseases; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Global Health; Homocysteine; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2006 |
Association of folate with hearing is dependent on the 5,10-methylenetetrahdyrofolate reductase 677C-->T mutation.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Auditory Threshold; Female; Folic Acid; Genetic Predisposition to Disease; Hearing Loss, Sensorineural; Homocysteine; Humans; Incidence; Male; Middle Aged; Mutation; Netherlands; Polymorphism, Genetic; Risk Assessment; Risk Factors; Severity of Illness Index; Vitamin B 12 | 2006 |
Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects.
Topics: Adult; Biomarkers; C-Reactive Protein; Cytokines; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Inflammation; Insulin; Interleukin-6; Interleukin-8; Male; Middle Aged; Overweight; Vitamin B Complex | 2006 |
Responsiveness of homocysteine concentrations to food and supplemental folate intakes in smokers and never-smokers enrolled in a diet intervention trial.
Topics: Adult; Cardiovascular Diseases; Counseling; Energy Intake; Feeding Behavior; Female; Folic Acid; Homocysteine; Humans; Plasma; Smoking | 2006 |
Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype.
Topics: Adolescent; Adult; Biological Products; Cytidine; Diet; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Thymidine | 2006 |
Effects of two different oral contraceptives on homocysteine metabolism in women with polycystic ovary syndrome.
Topics: Adult; Blood Glucose; Contraceptives, Oral; Cyproterone Acetate; Desogestrel; Ethinyl Estradiol; Female; Folic Acid; Homocysteine; Humans; Insulin; Insulin Resistance; Polycystic Ovary Syndrome; Vitamin B 12 | 2006 |
A phase II study of fixed-dose capecitabine and assessment of predictors of toxicity in patients with advanced/metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Diarrhea; Disease Progression; Fatigue; Female; Fluorouracil; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neoplasm Metastasis; Predictive Value of Tests; Survival Analysis | 2006 |
Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence.
Topics: Adenoma; Aged; Colorectal Neoplasms; Diet; Dietary Fiber; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Neoplasm Recurrence, Local; Risk Factors; Ursodeoxycholic Acid; Vitamin B Complex | 2006 |
No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease.
Topics: Aged; Arterial Occlusive Diseases; Biomarkers; Chronic Disease; Drug Therapy, Combination; Female; Folic Acid; Hemostasis; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation Mediators; Male; Middle Aged; Patient Compliance; Peripheral Vascular Diseases; Vasculitis; Vitamin B Complex | 2006 |
Efficacy of folic acid therapy for prevention of in-stent restenosis: a randomized clinical trial.
Topics: Coronary Angiography; Coronary Restenosis; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Stents | 2006 |
Folic acid 5 or 15 mg/d similarly reduces plasma homocysteine in patients with moderate-advanced chronic renal failure.
Topics: Aged; Double-Blind Method; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Middle Aged; Renal Replacement Therapy; Vitamin B Complex | 2006 |
Metabolic and genetic risk factors for migraine in children.
Topics: Adolescent; Child; Child, Preschool; Comorbidity; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Italy; Male; Metabolic Diseases; Methylenetetrahydrofolate Reductase (NADPH2); Migraine Disorders; Mutation; Prevalence; Risk Assessment; Risk Factors; Thrombosis | 2006 |
Effects of milk enriched with omega-3 fatty acid, oleic acid and folic acid in patients with metabolic syndrome.
Topics: Animals; Antioxidants; Apolipoproteins B; Blood Glucose; C-Reactive Protein; Cholesterol; Fatty Acids; Fatty Acids, Omega-3; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Insulin; Male; Metabolic Syndrome; Middle Aged; Milk; Phospholipids; Risk Factors; Triglycerides; Vitamin E | 2006 |
[The assessment of the influence of natural coffee and its modified form on the level of homocysteine, vitamin B6 and folic acid in healthy volunteers].
Topics: Adult; Caffeine; Central Nervous System Stimulants; Coffee; Double-Blind Method; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Male; Middle Aged; Smoking; Vitamin B 6 | 2006 |
Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Proteins; Regression Analysis; Renal Dialysis; Survival Analysis; Vitamin B Complex | 2006 |
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
Topics: Aged; Antiparkinson Agents; Canada; Catechols; Double-Blind Method; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Placebo Effect; Treatment Outcome; United States; Vitamin B 12; Vitamins | 2006 |
A controlled trial of homocysteine lowering and cognitive performance.
Topics: Aged; Cognition; Cognition Disorders; Dementia; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mental Status Schedule; Psychological Tests; Vitamin B 12; Vitamin B Complex | 2006 |
Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering.
Topics: Brachial Artery; C-Reactive Protein; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Endothelium, Vascular; Fasting; Female; Folic Acid; Homocysteine; Humans; Inflammation; Male; Middle Aged; Nitroglycerin; Vasodilation; Vasodilator Agents | 2006 |
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Cognition; Cognition Disorders; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Memory; Methylmalonic Acid; Psychomotor Performance; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Rationale and design of the Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT) trial.
Topics: Adult; Aged; Cardiovascular Diseases; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Recurrence; Vitamins | 2006 |
Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Proportional Hazards Models; Pulmonary Embolism; Pyridoxine; Recurrence; Risk Factors; Thrombophilia; Treatment Failure; Venous Thrombosis; Vitamin B 12 | 2007 |
B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans.
Topics: Adult; Aged; Alcohol Drinking; Anthropometry; Aspartate Aminotransferases; Austria; Diet; Diet, Vegetarian; Feeding Behavior; Female; Folic Acid; Glutathione Reductase; Homocysteine; Humans; Hyperhomocysteinemia; Male; Meat; Middle Aged; Pyridoxal Phosphate; Pyridoxic Acid; Riboflavin; Riboflavin Deficiency; Surveys and Questionnaires; Thiamine; Transketolase; Vegetables; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2006 |
Homocysteine but not neopterin declines in demented patients on B vitamins.
Topics: Dementia; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Neopterin; Thiamine; Vitamin B 12; Vitamin B 6; Vitamins | 2006 |
Effects of low- or high-dose hormone therapy on fasting and post-methionine homocysteine levels in postmenopausal women.
Topics: Dose-Response Relationship, Drug; Estradiol; Estrogen Replacement Therapy; Fasting; Female; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Norethindrone; Postmenopause; Prospective Studies; Risk Factors; Treatment Outcome; Vitamin B 12 | 2006 |
Changes in folate status in overweight/obese women following two different weight control programmes based on an increased consumption of vegetables or fortified breakfast cereals.
Topics: Adult; Anthropometry; Diet, Reducing; Eating; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Obesity; Overweight; Vegetables; Weight Loss | 2006 |
Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women.
Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Coronary Artery Disease; Double-Blind Method; Female; Ferritins; Folic Acid; Homocysteine; Humans; Iron; Isoflavones; Lipids; Middle Aged; Oxidative Stress; Phytic Acid; Plant Proteins, Dietary; Postmenopause; Regression Analysis; Risk Factors; Soybean Proteins; Transferrin; Vitamin B 12 | 2006 |
Effect of short-term folate and vitamin B supplementation on blood homocysteine level and carotid artery wall thickness in chronic hemodialysis patients.
Topics: Atherosclerosis; Carotid Arteries; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Treatment Outcome; Ultrasonography; Vitamin B 12; Vitamin B 6 | 2006 |
Effect of folic acid treatment on carotid intima-media thickness of patients with coronary disease.
Topics: Aged; Analysis of Variance; Carotid Artery Diseases; Carotid Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Middle Aged; Probability; Prognosis; Reference Values; Risk Assessment; Single-Blind Method; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography, Doppler | 2007 |
Effect of folate supplementation on N-terminal pro-brain natriuretic peptide.
Topics: Aged; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Sex Factors | 2007 |
Homocysteine reduction by B-vitamin supplementation increases t-PA and PAI-1 levels in patients with venous thromboembolism.
Topics: Adolescent; Adult; Aged; Dietary Supplements; Double-Blind Method; Drug Combinations; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Middle Aged; Plasminogen Activator Inhibitor 1; Pulmonary Embolism; Pyridoxine; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Venous Thrombosis; Vitamin B 12; Vitamin B Complex | 2007 |
Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh.
Topics: Adult; Aged; Arsenic; Arsenicals; Bangladesh; Creatine; Creatinine; Dietary Supplements; Double-Blind Method; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Skin Neoplasms; Urinary Bladder Neoplasms; Vitamin B Complex; Water Pollutants, Chemical | 2006 |
Folate supplementation fails to affect vascular function and carotid artery intima media thickness in cyclosporin A-treated renal transplant recipients.
Topics: Brachial Artery; Carotid Arteries; Cross-Over Studies; Cyclosporine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Treatment Outcome; Tunica Intima; Tunica Media | 2006 |
Effect of fortified spread on homocysteine concentration in apparently healthy volunteers.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Sex Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Homocysteine, MTHFR C677 T, vitamin B12, and folate levels in Thai children with ischemic stroke: a case-control study.
Topics: Adolescent; Child; Child, Preschool; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Ischemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Polymorphism, Single Nucleotide; Retrospective Studies; Risk Factors; Stroke; Thailand; Thrombosis; Vitamin B 12 | 2006 |
Effects of folic acid supplementation on hearing in older adults: a randomized, controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Auditory Threshold; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Hearing Loss, Sensorineural; Homocysteine; Humans; Male; Middle Aged | 2007 |
Oral vitamin B12 supplementation reduces plasma total homocysteine concentration in women in India.
Topics: Administration, Oral; Adult; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Middle Aged; Prevalence; Treatment Outcome; Vegetables; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2007 |
Effect of increased vegetable and fruit consumption on plasma folate and homocysteine concentrations.
Topics: Adult; Female; Folic Acid; Fruit; Homocysteine; Humans; Netherlands; Nutrition Assessment; Nutrition Policy; Nutritional Requirements; Vegetables; Vitamin B Complex; Women's Health | 2007 |
Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial.
Topics: Aged; Apolipoproteins E; Cognition; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Memory; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Netherlands; Psychological Tests; Vitamin B Complex | 2007 |
Plasma homocysteine levels in patients treated with levodopa: motor and cognitive associations.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Case-Control Studies; Cognition; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Levodopa; Male; Middle Aged; Motor Activity; Neuropsychological Tests; Parkinson Disease; Statistics, Nonparametric; Vitamin B 12 | 2006 |
Effect of folic acid on endothelial function following acute myocardial infarction.
Topics: Brachial Artery; Chi-Square Distribution; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Treatment Outcome; Vitamin B Complex | 2007 |
Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study.
Topics: Adult; Aged; Biomarkers; Female; Folic Acid; Follow-Up Studies; Hip Fractures; Homocysteine; Humans; Male; Middle Aged; Osteoporosis; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prospective Studies; Risk Factors; Vitamin B 12 | 2007 |
Fortified mineral water improves folate status and decreases plasma homocysteine concentration in pregnant women.
Topics: Adult; Calcium; Dietary Supplements; Double-Blind Method; Female; Finland; Folic Acid; Homocysteine; Humans; Mineral Waters; Pregnancy; Prenatal Care; Vitamin B 12; Vitamin B 6; Vitamin D | 2007 |
Folic acid therapy reduces plasma homocysteine levels and improves plasma antioxidant capacity in hemodialysis patients.
Topics: Cardiovascular Diseases; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hydrogen Peroxide; Hyperhomocysteinemia; Lipid Peroxidation; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Renal Dialysis; Time Factors; Vitamin B Complex | 2007 |
MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians.
Topics: Asian People; Case-Control Studies; Cytosine; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Humans; Hypertension; India; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Thymine | 2007 |
Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women.
Topics: Cross-Over Studies; DNA Methylation; Double-Blind Method; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Replacement Therapy; Female; Folic Acid; Genes, p16; Homocysteine; Humans; Middle Aged; Postmenopause; Vitamin B 12; Vitamin B 6 | 2007 |
Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome.
Topics: Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Metformin; Methylenetetrahydrofolate Reductase (NADPH2); Polycystic Ovary Syndrome; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Prospective Studies; Testosterone; Vitamin B 12 | 2007 |
[Effects of intervention therapy of methylcobalamin and folic acid on plasma homocysteine concentration and homocysteine thiolactonases/paraoxonase activity in patients with type 2 diabetes mellitus].
Topics: Administration, Oral; Adult; Aged; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Injections, Intramuscular; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B Complex | 2007 |
Lowering homocysteine with B vitamins has no effect on blood pressure in older adults.
Topics: Aged; Blood Pressure; Diastole; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Male; Osmolar Concentration; Systole; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study.
Topics: Absorptiometry, Photon; Adipose Tissue; Adiposity; Aged; Alcohol Drinking; Body Composition; Body Mass Index; Cross-Over Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Multivariate Analysis; Obesity; Overweight; Postmenopause; Vitamin B 12 | 2008 |
The risk of recurrent cardiovascular events in patients with increased plasma homocysteine levels is reduced by short but not long-term therapy with folate and B vitamins.
Topics: Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Recurrence; Risk Factors; Time Factors; Treatment Outcome; Vitamin B Complex | 2007 |
Homocysteine, folate and cobalamin levels in hypothyroid women before and after treatment.
Topics: Adult; Creatine; Female; Folic Acid; Homocysteine; Humans; Hypothyroidism; Middle Aged; Thyrotropin; Thyroxine; Vitamin B 12 | 2007 |
The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled study.
Topics: Chromatography, High Pressure Liquid; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Transplantation; Male; Middle Aged; Prospective Studies; Tetrahydrofolates; Treatment Outcome | 2008 |
The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people.
Topics: Aged; Attention; Betaine; Choline; Cognition; Double-Blind Method; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Male; Memory; Neuropsychological Tests; Psychomotor Performance; Sarcosine; Vitamin B 12; Vitamin B Complex | 2007 |
Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxid
Topics: Administration, Oral; Carotid Artery, Common; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Follow-Up Studies; Glomerular Filtration Rate; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Failure, Chronic; Male; Middle Aged; Oxidative Stress; Pravastatin; Pyridoxine; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Ultrasonography; Vitamin E; Vitamins | 2007 |
Improvement of endothelial function in uraemic patients on peritoneal dialysis: a possible role for 5-MTHF administration.
Topics: Aged; Diabetic Nephropathies; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis; Tetrahydrofolates; Ultrasonography; Uremia; Vasodilation | 2007 |
A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Chi-Square Distribution; Cholinesterase Inhibitors; Dietary Supplements; Donepezil; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Galantamine; Homocysteine; Humans; Indans; Male; Mental Status Schedule; Phenylcarbamates; Piperidines; Placebos; Rivastigmine; Treatment Outcome; Vitamin B Complex; Vitamins | 2008 |
Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients.
Topics: C-Reactive Protein; Female; Folic Acid; Homocysteine; Humans; Male; Renal Dialysis; Serum Albumin; Vitamin B Complex | 2007 |
Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; CD40 Ligand; Cholesterol, LDL; Coronary Artery Disease; Double-Blind Method; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Interleukin-6; Male; Middle Aged; Neopterin; Prospective Studies; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Four week supplementation with mixed fruit and vegetable juice concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine in Japanese subjects.
Topics: Adult; Antioxidants; Biological Availability; Biomarkers; Capsules; Dietary Supplements; DNA Damage; Double-Blind Method; Female; Folic Acid; Fruit; Homocysteine; Humans; Japan; Lipid Peroxidation; Male; Oxidation-Reduction; Oxidative Stress; Smoking; Vegetables | 2007 |
Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; DNA Methylation; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Intestinal Mucosa; Male; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Promoter Regions, Genetic; Uracil; Vitamin B 12 | 2007 |
Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.
Topics: Aged; Cause of Death; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Middle Aged; Proportional Hazards Models; Pyridoxine; Renal Insufficiency, Chronic; Vascular Diseases; Vitamin B 12; Vitamin B Complex | 2007 |
Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Deoxyuridine; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Lung Neoplasms; Male; Methylmalonic Acid; Middle Aged; Pemetrexed; Thymidine; Thymidylate Synthase; Vinblastine; Vinorelbine; Vitamin B 12 | 2007 |
Folic acid supplementation lowers blood arsenic.
Topics: Arsenic; Arsenicals; Bangladesh; Dietary Supplements; Double-Blind Method; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Vitamin B Complex; Water Pollutants, Chemical | 2007 |
Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).
Topics: Adenomatous Polyposis Coli; Adult; Aged; Aged, 80 and over; Alleles; Biomarkers, Tumor; Biopsy; Colonoscopy; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Genetic Carrier Screening; Genetic Variation; Genotype; Homocysteine; Humans; Intestinal Mucosa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Riboflavin; Sigmoidoscopy; Tetrahydrofolates | 2007 |
Randomized clinical trial of homocysteine level lowering therapy and fractures.
Topics: Aged; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Fractures, Bone; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Male; Middle Aged; Proportional Hazards Models; Pyridoxine; Risk Factors; Treatment Outcome; Vitamin B 12 | 2007 |
Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12064 myocardial infarction survivors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Cholesterol; Dose-Response Relationship, Drug; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Retrospective Studies; Simvastatin; Survival Rate; Time Factors; Treatment Outcome; United Kingdom; Vitamin B 12; Vitamin B Complex | 2007 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; India; Infant; Male; Methylmalonic Acid; Nutritional Status; Socioeconomic Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease--results of the renal Hope-2 study.
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Vitamin B 12; Vitamin B 6 | 2008 |
Folate augmentation of treatment - evaluation for depression (FolATED): protocol of a randomised controlled trial.
Topics: Adult; Antidepressive Agents, Second-Generation; Cohort Studies; Cost-Benefit Analysis; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Family Practice; Female; Fluoxetine; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Psychiatry | 2007 |
The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial.
Topics: Aged; Aged, 80 and over; Biomarkers; Bone Density; Bone Remodeling; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Osteoporosis; Placebos; Vitamin B 12; Vitamin B Complex | 2007 |
[Reducing plasma homocysteic acid lowers serum C-reactive protein level in children with Kawasaki disease].
Topics: Aspirin; C-Reactive Protein; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Immunoglobulins, Intravenous; Infant; Male; Mucocutaneous Lymph Node Syndrome; Vitamin B 6 | 2007 |
Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients.
Topics: Aged; Alzheimer Disease; Asian People; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Indans; Male; Piperidines; Taiwan; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
[Efficacy and safety of Enalapril-Folate acid tablets in lowering blood pressure and plasma homocysteine].
Topics: Blood Pressure; Double-Blind Method; Enalapril; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Tablets | 2007 |
Decreased plasma folate concentration in young and elderly healthy subjects after a short-term supplementation with isotretinoin.
Topics: Acne Vulgaris; Adult; Aged; Aging; Dermatologic Agents; Dietary Supplements; Folic Acid; Homocysteine; Humans; Isotretinoin; Male; Tetrahydrofolates | 2008 |
Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease.
Topics: Acetylcysteine; Administration, Oral; Aged; Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged | 2007 |
Fluorouracil-based chemotherapy in patients with gastrointestinal malignancies: influence of nutritional folate status on toxicity.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Folic Acid; Gastrointestinal Neoplasms; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2007 |
The effect of oral folic acid upon plasma homocysteine, endothelial function and oxidative stress in patients with type 1 diabetes and microalbuminuria.
Topics: Administration, Oral; Adult; Albuminuria; Blood Flow Velocity; Diabetes Mellitus, Type 1; Endothelium, Vascular; Enzyme Inhibitors; Female; Folic Acid; Forearm; Homocysteine; Humans; Male; omega-N-Methylarginine; Oxidative Stress | 2008 |
Lowering plasma homocysteine concentrations of older men and women with folate, vitamin B-12, and vitamin B-6 does not affect the proportion of (n-3) long chain polyunsaturated fatty acids in plasma phosphatidylcholine.
Topics: Aged; Double-Blind Method; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Humans; Male; Phosphatidylcholines; Time Factors; Vitamin B 12; Vitamin B 6 | 2008 |
Effect of folic acid in women with and without insulin resistance who have hyperhomocysteinemic polycystic ovary syndrome.
Topics: Adolescent; Adult; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Insulin Resistance; Polycystic Ovary Syndrome; Prospective Studies; Vitamin B Complex | 2008 |
Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity.
Topics: Abdominal Fat; Adiponectin; Adult; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cardiovascular Diseases; Cell Adhesion Molecules; Diet, Carbohydrate-Restricted; Diet, Reducing; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Obesity; Risk Factors; Treatment Outcome; Weight Loss | 2008 |
Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery.
Topics: Adult; Aged; Anesthetics, Inhalation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intraoperative Period; Male; Middle Aged; Nitrous Oxide; Postoperative Complications; Risk Assessment; Risk Factors | 2008 |
Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial.
Topics: Adult; Aged; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Risk; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation.
Topics: Breast Feeding; Dietary Supplements; Folic Acid; Homocysteine; Humans; Infant; Linear Models; Methylmalonic Acid; Vitamin B 12 | 2008 |
Plasma homocysteine level is elevated in patients on isotretinoin therapy for cystic acne: a prospective controlled study.
Topics: Acne Vulgaris; Adolescent; Adult; Dermatologic Agents; Female; Folic Acid; Homocysteine; Humans; Isotretinoin; Liver Function Tests; Male; Prospective Studies; Vitamin B 12; Young Adult | 2008 |
Weekly may be as efficacious as daily folic acid supplementation in improving folate status and lowering serum homocysteine concentrations in Guatemalan women.
Topics: Adolescent; Adult; Dietary Supplements; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Guatemala; Homocysteine; Humans; Middle Aged; Vitamin B 12; Vitamins | 2008 |
Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Placebos; Selenium; United Kingdom; Vitamin B Complex | 2008 |
[Effect of low-dose folate treatment on plasma homocystyeine and chemokine levels in patients with hyperhomocysteinemia].
Topics: Aged; Chemokines; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Treatment Outcome | 2008 |
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial.
Topics: Aged; Aging; Bread; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial.
Topics: Adult; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Homocysteine; Humans; Nutritional Status | 2008 |
Consumption of restructured meat products with added walnuts has a cholesterol-lowering effect in subjects at high cardiovascular risk: a randomised, crossover, placebo-controlled study.
Topics: Aged; Animals; Cardiovascular Diseases; Cattle; Cholesterol; Cross-Over Studies; Female; Folic Acid; gamma-Tocopherol; Homocysteine; Humans; Juglans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Meat Products; Middle Aged; Platelet Function Tests; Postprandial Period; Triglycerides; Vitamin B 12; Vitamin B 6 | 2008 |
Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial.
Topics: Aged; Aortic Valve Stenosis; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Effect of folic acid combined with fluoxetine in patients with major depression on plasma homocysteine and vitamin B12, and serotonin levels in lymphocytes.
Topics: Adult; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Lymphocytes; Male; Middle Aged; Neuropsychological Tests; Selective Serotonin Reuptake Inhibitors; Serotonin; Severity of Illness Index; Treatment Outcome; Vitamin B 12; Vitamin B Complex; Young Adult | 2008 |
Effects of plasma homocysteine levels on serum HTase/PON activity in patients with type 2 diabetes.
Topics: Adult; Aged; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Vitamins | 2008 |
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.
Topics: Adult; Aged; Anticholesteremic Agents; Arginine; Carotid Arteries; Chronic Disease; Creatinine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Lipoproteins, LDL; Male; Middle Aged; Pravastatin; Vitamin B 12; Vitamin B 6; Vitamin E | 2009 |
Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers--a randomized, crossover intervention study.
Topics: Adult; Aged; Alcohol Drinking; Cross-Over Studies; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Vitamin B 12; Young Adult | 2008 |
The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis.
Topics: Aged; Carotid Arteries; Dietary Supplements; Double-Blind Method; Down-Regulation; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Regional Blood Flow; Stroke; Time Factors; Treatment Outcome; Tunica Intima; Tunica Media; Vasodilation; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cognition Disorders; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Psychiatric Status Rating Scales; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: baseline data from the Homocysteine and Atherosclerosis Reduction Trial (HART).
Topics: Aged; Biomarkers; Calcinosis; Canada; Cardiovascular Diseases; Carotid Artery Diseases; Carotid Artery, Common; Disease Progression; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women.
Topics: Adult; Biomarkers; Cell Count; Cholesterol; Cholesterol, LDL; Diet; Endothelial Cells; Female; Folic Acid; Homocysteine; Humans; Japan; Magnesium; Potassium; Reactive Oxygen Species; Stem Cells; Vegetables; Young Adult | 2009 |
Baseline characteristics of participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial.
Topics: Adult; Brazil; Canada; Cardiovascular Diseases; Chronic Disease; Cohort Studies; Creatinine; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Male; Middle Aged; Risk Factors; Treatment Outcome; United States; Vitamin B Complex | 2009 |
Long-term garlic or micronutrient supplementation, but not anti-Helicobacter pylori therapy, increases serum folate or glutathione without affecting serum vitamin B-12 or homocysteine in a rural Chinese population.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Asian People; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Garlic; Glutathione; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Male; Micronutrients; Middle Aged; Omeprazole; Rural Population; Vitamin B 12 | 2009 |
A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Chi-Square Distribution; Cognition; Cognition Disorders; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Psychometrics; Risk Factors; Statistics, Nonparametric; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Increasing the number of SNP loci does not necessarily improve prediction power at least in the comparison of MTHFR SNP and haplotypes.
Topics: Atherosclerosis; Cysteine; Double-Blind Method; Folic Acid; Genetic Markers; Haplotypes; Homocysteine; Humans; Linkage Disequilibrium; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Predictive Value of Tests; Sequence Analysis, DNA; Threonine; Tokyo; Vitamin B Complex | 2008 |
[The effect of baseline homocysteine level on the efficacy of enalapril maleate and folic acid tablet in lowering blood pressure and plasma homocysteine].
Topics: Adolescent; Adult; Aged; Double-Blind Method; Enalapril; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged | 2008 |
Dietary intervention with emphasis on folate intake reduces serum lipids but not plasma homocysteine levels in hyperlipidemic patients.
Topics: Adult; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Chi-Square Distribution; Diet; Diet Records; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Korea; Lipids; Male; Middle Aged; Vitamins | 2008 |
Milk enriched with "healthy fatty acids" improves cardiovascular risk markers and nutritional status in human volunteers.
Topics: Animals; Biomarkers; Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Fatty Acids; Folic Acid; Food, Fortified; Homocysteine; Humans; Milk; Nutrition Assessment; Risk Factors; Sterols; Triglycerides; Vitamins | 2009 |
Comparison study on the effect of prenatal administration of high dose and low dose folic acid.
Topics: Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, First; Single-Blind Method | 2009 |
Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial.
Topics: Aged; Amyloid beta-Peptides; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Down-Regulation; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Osmolar Concentration; Peptide Fragments; Pyridoxine; Stroke; Treatment Failure; Vitamin B 12; Vitamin B Complex; Vitamins | 2009 |
Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet.
Topics: Anxiety; Celiac Disease; Depressive Disorder; Diet, Gluten-Free; Female; Folic Acid; Health Status; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Surveys and Questionnaires; Vitamin B 12; Vitamin B Complex | 2009 |
Effect of 2 pieces of nutritional advice on folate status in Swedish women: a randomized controlled trial.
Topics: Adult; Bread; Edible Grain; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Middle Aged; Neural Tube Defects; Nutrition Policy; Nutritional Requirements; Nutritional Status; Sweden | 2009 |
The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial.
Topics: Aged; Carotid Artery Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Placebos; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography; Vitamin B Complex | 2010 |
Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: a randomised double-blind, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aorta; Arteritis; Atherosclerosis; Brachial Artery; Carotid Arteries; Cross-Sectional Studies; Double-Blind Method; Drug Combinations; Female; Femoral Artery; Fluorodeoxyglucose F18; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Stroke; Time Factors; Treatment Outcome; Ultrasonography; Vasodilation; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2009 |
Zinc supplementation does not alter plasma homocysteine, vitamin B12 and red blood cell folate concentrations in French elderly subjects.
Topics: Age Factors; Aged; Dietary Supplements; Erythrocytes; Female; Folic Acid; France; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Zinc | 2009 |
Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial.
Topics: Aged; Disability Evaluation; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Kaplan-Meier Estimate; Male; Middle Aged; Risk Factors; Severity of Illness Index; Stroke; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamins | 2009 |
Association between folate intake from different food sources in Norway and homocysteine status in a dietary intervention among young male adults.
Topics: Adolescent; Adult; Bread; Diet; Dietary Fiber; Energy Intake; Feeding Behavior; Folic Acid; Fruit; Health Promotion; Homocysteine; Humans; Male; Norway; Riboflavin; Vegetables; Young Adult | 2009 |
Controlled study on folate status following folic acid supplementation and discontinuation in women of child-bearing age.
Topics: Adult; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Neural Tube Defects; Plasma; Serum; Young Adult | 2009 |
Dietary and supplementary betaine: effects on betaine and homocysteine concentrations in males.
Topics: Adult; Betaine; Biomarkers; Choline; Creatinine; Cross-Over Studies; Diet; Dietary Supplements; Folic Acid; Homocysteine; Humans; Lipids; Male; Sarcosine; Time Factors; Vitamin B 12; Young Adult | 2009 |
Effect of Sclerovit on endothelial dysfunction, hemorheological parameters, platelet aggregation, plasma concentration of homocysteine and progression of atherosclerosis in patients with vascular diseases.
Topics: Aged; Atherosclerosis; Carotid Stenosis; Drug Combinations; Erythrocyte Deformability; Female; Folic Acid; Hemorheology; Homocysteine; Humans; Male; Middle Aged; Platelet Aggregation; Tunica Intima; Tunica Media; Vasodilation; Vitamin B 12; Vitamin B 6; Vitamin E; von Willebrand Factor | 2009 |
Role of folic acid in atherosclerosis after kidney transplant: a double-blind, randomized, placebo-controlled clinical trial.
Topics: Administration, Oral; Adult; Cardiovascular Agents; Carotid Artery Diseases; Carotid Artery, Common; Carotid Artery, Internal; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Time Factors; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography, Doppler | 2009 |
Ethnicity does not affect the homocysteine-lowering effect of B-vitamin therapy in Singaporean stroke patients.
Topics: Aged; China; Diet; Ethnicity; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; India; Malaysia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Risk Factors; Singapore; Stroke; Vitamin B Complex | 2009 |
Riboflavin supplementation and biomarkers of cardiovascular disease in the elderly.
Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Ferritins; Folic Acid; Geriatric Assessment; Homocysteine; Humans; Male; Nutritional Status; Portugal; Riboflavin; Uric Acid; Vitamin B Complex | 2009 |
Folate status in young overweight and obese women: changes associated with weight reduction and increased folate intake.
Topics: Adult; Analysis of Variance; Caloric Restriction; Diet, Reducing; Edible Grain; Female; Folic Acid; Homocysteine; Humans; Linear Models; Nutritional Status; Obesity; Overweight; Vegetables; Weight Loss; Young Adult | 2009 |
Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial.
Topics: Adult; Aged; Ascorbic Acid; beta Carotene; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Middle Aged; Placebos; Proportional Hazards Models; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin E | 2009 |
Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina.
Topics: Acute Coronary Syndrome; Adult; Aged; Angina, Unstable; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Vasodilation; Vitamin B 12; Vitamin B Complex | 2009 |
Adiponectin relates to smooth muscle function and folate in obese children.
Topics: Adiponectin; Adolescent; Body Mass Index; Child; Cholesterol, LDL; Cross-Sectional Studies; Endothelium, Vascular; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Muscle, Smooth, Vascular; Nitroglycerin; Obesity; Vasodilation; Waist Circumference | 2010 |
Randomized clinical trial of folate supplementation in patients with peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Blood Flow Velocity; Cardiovascular Agents; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Intermittent Claudication; Male; Middle Aged; Tetrahydrofolates; Treatment Outcome | 2009 |
Efficacy of folate and vitamin B12 in lowering homocysteine concentrations in hemodialysis patients.
Topics: Administration, Oral; Adult; Aged; Biomarkers; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nutritional Status; Prospective Studies; Renal Dialysis; Treatment Outcome; Vitamin B 12; Vitamin B Complex | 2009 |
Effect of folate supplementation on serum homocysteine and plasma total antioxidant capacity in hypercholesterolemic adults under lovastatin treatment: a double-blind randomized controlled clinical trial.
Topics: Adult; Anticholesteremic Agents; Antioxidants; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Vitamin B Complex | 2009 |
Serum homocysteine, folate and vitamin B12 in patients with Paget's disease of bone: the effect of zoledronic acid.
Topics: 25-Hydroxyvitamin D 2; Aged; Alkaline Phosphatase; Biomarkers; Body Mass Index; Bone Density Conservation Agents; Bone Neoplasms; Bone Remodeling; Calcifediol; Cohort Studies; Collagen Type I; Diphosphonates; Female; Folic Acid; Homocysteine; Humans; Imidazoles; Isoenzymes; Male; Paget Disease, Extramammary; Peptides; Pilot Projects; Time Factors; Vitamin B 12; Zoledronic Acid | 2010 |
Homocysteine lowering with folic acid supplements in children: effects on blood pressure.
Topics: Adolescent; Age Factors; Blood Pressure; Child; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B Complex | 2010 |
Red clover (Trifolium pratense) isoflavones and serum homocysteine in premenopausal women: a pilot study.
Topics: Adult; Double-Blind Method; Female; Folic Acid; Follicular Phase; Homocysteine; Humans; Isoflavones; Luteal Phase; Menstrual Cycle; Middle Aged; Pilot Projects; Premenopause; Trifolium; Young Adult | 2009 |
[Efficacy of enalapril combined with folic acid in lowering blood pressure and plasma homocysteine level].
Topics: Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Enalapril; Female; Folic Acid; Homocysteine; Humans; Hypotension; Male; Middle Aged; Treatment Outcome | 2009 |
Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamins | 2010 |
Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Japan; Male; Middle Aged; Mitochondrial Proton-Translocating ATPases; Oxidative Phosphorylation Coupling Factors; Stroke; Vitamin B 12; Vitamin B Complex | 2010 |
The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life.
Topics: Age Factors; Antidepressive Agents; Biomarkers; Citalopram; Depression; Double-Blind Method; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Medication Adherence; Middle Aged; Psychiatric Status Rating Scales; Research Design; Severity of Illness Index; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Western Australia | 2010 |
Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women.
Topics: Adolescent; Adult; Diet; Diet Records; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Methionine; Micronutrients; Neural Tube Defects; Nutritional Status; Reference Values; Riboflavin; Time Factors; Vitamin B 12; Vitamin B 6; Young Adult | 2009 |
Effect of a Klamath algae product ("AFA-B12") on blood levels of vitamin B12 and homocysteine in vegan subjects: a pilot study.
Topics: Adult; Aphanizomenon; Biomarkers; Diet, Vegetarian; Dietary Supplements; Folic Acid; Homocysteine; Humans; Intestinal Absorption; Middle Aged; Pilot Projects; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2009 |
Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients.
Topics: Blood Flow Velocity; Blood Pressure; Brachial Artery; Diet, Carbohydrate-Restricted; Diet, Fat-Restricted; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Middle Aged; Obesity; Overweight; Vitamin B 12; Weight Loss | 2010 |
Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation.
Topics: Adult; Blood Coagulation; Blood Proteins; Dietary Supplements; Drug Administration Schedule; Female; Folic Acid; Homocysteine; Humans; Immunity; Inflammation; Male; Proteome; Proteomics; S-Adenosylmethionine; Tetrahydrofolates | 2010 |
The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber.
Topics: Aged; Aged, 80 and over; Avena; Biological Availability; Constipation; Dietary Fiber; Dietary Supplements; Energy Intake; Folic Acid; Homocysteine; Humans; Laxatives; Middle Aged; Nursing Homes; Phytotherapy; Seeds; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B Complex | 2010 |
Pilot study of folate status in healthy volunteers and in patients with psoriasis before and after UV exposure.
Topics: Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Pilot Projects; Psoriasis; Severity of Illness Index; Ultraviolet Rays; Ultraviolet Therapy; Vitamin D | 2010 |
Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India.
Topics: Adult; Child; Dietary Supplements; Double-Blind Method; Family; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2010 |
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.
Topics: Administration, Oral; Aged; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intravenous; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors; Vitamin B 12; Vitamin B Complex | 2010 |
Pre-operative vitamin B infusion and prevention of nitrous oxide-induced homocysteine increase.
Topics: Adult; Anesthetics, Inhalation; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitrous Oxide; Preanesthetic Medication; Prospective Studies; Vitamin B 12; Vitamin B Complex | 2010 |
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Long-Term Care; Male; Metformin; Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2010 |
Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a Western Norway B Vitamin Intervention Trial (WENBIT) substudy.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Coronary Angiography; Coronary Artery Disease; Disease Progression; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Norway; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2010 |
Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Morbidity; Myocardial Infarction; Treatment Outcome; Vitamin B 12; Vitamin B Complex | 2010 |
Hyperhomocysteinemia prevalence among patients with venous thromboembolism.
Topics: Adult; Aged; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prevalence; Risk Factors; Venous Thrombosis; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Effects of oral folate supplementation on serum total homocysteine and cholesterol levels in hyperhomocysteinemic children.
Topics: Child; Cholesterol; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B Complex | 2010 |
Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults.
Topics: Aged; Aged, 80 and over; Aging; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2011 |
The effect of folinic acid supplementation on homocysteine concentrations in newborns.
Topics: Cerebrovascular Disorders; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Leucovorin; Male; Prospective Studies; Risk Factors | 2010 |
Do novel risk biomarkers reflect the severity of peripheral arterial disease?
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Biomarkers; Blood Coagulation Factors; Blood Flow Velocity; C-Reactive Protein; Female; Folic Acid; Homocysteine; Humans; Inflammation Mediators; Lipids; Male; Middle Aged; Peripheral Arterial Disease; Predictive Value of Tests; Severity of Illness Index; Vitamin B 12 | 2011 |
Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Aspirin; Colorectal Neoplasms; Double-Blind Method; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Recurrence, Local; Surveys and Questionnaires; Young Adult | 2010 |
Effects of folic acid supplementation on serum folate and plasma homocysteine concentrations in older adults: a dose-response trial.
Topics: Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B Complex | 2010 |
Effect of an antioxidant drink on homocysteine levels in Alzheimer's patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Cross-Sectional Studies; Double-Blind Method; Female; Flavonoids; Folic Acid; Homocysteine; Humans; Male; Neuropsychological Tests; Oxidative Stress; Phenols; Polyphenols; Statistics, Nonparametric; Treatment Outcome; Vitamin B 12 | 2010 |
Vitamins B(12), B(6), and folic acid for cognition in older men.
Topics: Aged; Aged, 80 and over; Cognition; Cognition Disorders; Community Health Planning; Dementia; Dietary Supplements; Double-Blind Method; Folic Acid; Follow-Up Studies; Geriatrics; Homocysteine; Humans; Male; Neuropsychological Tests; Patient Compliance; Time Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2010 |
A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy.
Topics: Aged; Dose-Response Relationship, Drug; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Myocardial Ischemia; Neural Tube Defects; Nutrition Policy; Vitamin B 12 | 2011 |
Preconception folic acid use modulates estradiol and follicular responses to ovarian stimulation.
Topics: Adult; Anti-Mullerian Hormone; Biomarkers; Estradiol; Female; Fertilization in Vitro; Folic Acid; Gonadotropins; Homocysteine; Humans; Infertility, Female; Male; Ovarian Follicle; Ovulation Induction; Sperm Injections, Intracytoplasmic; Treatment Outcome; Vitamins | 2011 |
Comparison of oral folic acid and folinic acid on blood homocysteine level of patients on hemodialysis.
Topics: Administration, Oral; Biomarkers; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Middle Aged; Renal Dialysis; Statistics, Nonparametric | 2011 |
A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Dementia, Vascular; Depression; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Hong Kong; Humans; Hyperhomocysteinemia; Male; Neuropsychological Tests; Patient Dropouts; Vitamin B 12; Vitamin B Complex | 2011 |
Effect of different doses of folic acid on serum homocysteine level in patients on hemodialysis.
Topics: Aged; Aged, 80 and over; Cross-Over Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 2011 |
Impact of spinach consumption on DNA stability in peripheral lymphocytes and on biochemical blood parameters: results of a human intervention trial.
Topics: Antioxidants; Blood Cells; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Comet Assay; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Endpoint Determination; Female; Folic Acid; Homocysteine; Humans; Hydrogen Peroxide; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Oxidative Stress; Phytotherapy; Plant Leaves; Plant Preparations; Reactive Oxygen Species; Spinacia oleracea; Triglycerides; Vitamin A; Vitamin B 12; Vitamin E | 2011 |
Coronary blood flow in patients with stable coronary artery disease treated long term with folic acid and vitamin B12.
Topics: Acetylcholine; Adenosine; Aged; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Laser-Doppler Flowmetry; Male; Middle Aged; Time Factors; Vitamin B 12; Vitamin B 6 | 2011 |
Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults.
Topics: Aged; Atherosclerosis; Carotid Artery Diseases; Carotid Artery, Common; Dietary Supplements; Disease Progression; Double-Blind Method; Elasticity; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Netherlands; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography | 2011 |
Influence of diabetes on homocysteine-lowering therapy in chronic hemodialysis patients.
Topics: Biomarkers; C-Reactive Protein; Diabetes Complications; Dietary Supplements; Folic Acid; Homocysteine; Humans; Inflammation; Male; Middle Aged; Regression Analysis; Renal Dialysis; Uremia; Vitamin B 12 | 2011 |
MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.
Topics: China; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Regression Analysis | 2011 |
Cobalamin status modifies the effect of zinc supplementation on the incidence of prolonged diarrhea in 6- to 30-month-old north Indian children.
Topics: Child, Preschool; Diarrhea; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Incidence; India; Infant; Male; Methylmalonic Acid; Vitamin B 12; Zinc | 2011 |
Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension.
Topics: Aged; Aged, 80 and over; Anatomy, Cross-Sectional; Atrophy; Brain; Cerebral Infarction; Disease Progression; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hypertension; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Prognosis; Regression Analysis; Riboflavin; Risk Factors | 2011 |
Genetic variation in folate metabolism is not associated with cognitive functioning or mood in healthy adults.
Topics: Adult; Affect; Aged; Aged, 80 and over; Carotid Intima-Media Thickness; Cognition; Double-Blind Method; Education; Female; Folic Acid; Genetic Variation; Genotype; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neuropsychological Tests; Placebos; Polymorphism, Genetic; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Vitamin B Complex | 2011 |
Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; India; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognition; Cognition Disorders; Double-Blind Method; Executive Function; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Memory; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2012 |
DNA methylation and cognitive functioning in healthy older adults.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Aging; Cognitive Dysfunction; Cross-Sectional Studies; Cytosine; DNA Methylation; Double-Blind Method; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Genetic Association Studies; Homocysteine; Humans; Leukocytes; Male; Middle Aged; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales | 2012 |
Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus.
Topics: Administration, Oral; Aged; Antioxidants; Diabetes Mellitus, Type 2; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Folic Acid; Homocysteine; Humans; Male; Malondialdehyde; Metformin; Middle Aged; Oxidative Stress; Vitamin B 12 | 2011 |
Implant overdentures and nutrition: a randomized controlled trial.
Topics: Aged; Dental Prosthesis, Implant-Supported; Denture, Complete, Lower; Denture, Overlay; Elder Nutritional Physiological Phenomena; Female; Folic Acid; Fruit; Homocysteine; Humans; Linear Models; Male; Mastication; Nutritional Status; Serum Albumin; Vegetables; Vitamin B 12; Vitamin B 6 | 2012 |
No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine.
Topics: Aged; Chromatography, Liquid; Dietary Supplements; DNA Methylation; Double-Blind Method; Female; Folic Acid; Genotype; Homocysteine; Humans; Leukocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Models, Statistical; Placebos; Postmenopause; Smoking; Tandem Mass Spectrometry | 2011 |
Poor folate status predicts persistent diarrhea in 6- to 30-month-old north Indian children.
Topics: Biomarkers; Child, Preschool; Diarrhea; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; India; Infant; Interviews as Topic; Male; Prospective Studies; Risk Factors; Treatment Outcome; Vitamin B 12 | 2011 |
Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.
Topics: Adolescent; Adult; Androstenes; Calcium; Contraceptives, Oral; Double-Blind Method; Estrogens; Ethinyl Estradiol; Female; Folic Acid; Glutamates; Homocysteine; Humans; Mineralocorticoid Receptor Antagonists; Neural Tube Defects; Treatment Outcome; Young Adult | 2012 |
Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non-controlled study.
Topics: Acne Vulgaris; Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Dermatologic Agents; Female; Folic Acid; Homocysteine; Humans; Isotretinoin; Male; Transcobalamins; Triglycerides; Vitamin B 12; Young Adult | 2011 |
Analysis of perinatal outcome by combination of first trimester maternal plasma homocysteine with uterine artery Doppler velocimetry.
Topics: Adult; Biomarkers; Blood Flow Velocity; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Humans; Hypertension, Pregnancy-Induced; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Premature Birth; Prognosis; Prospective Studies; Rheology; Ultrasonography, Prenatal; Uterine Artery; Vitamin B 12 | 2011 |
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Middle Aged; Northern Ireland; Nutritional Status; Patient Compliance; Postmenopause | 2012 |
MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Antihypertensive Agents; China; Double-Blind Method; Enalapril; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2012 |
The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dietary Supplements; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Valproic Acid; Vitamin B 12; Vitamin B Complex; Young Adult | 2012 |
Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults.
Topics: Adult; Cardiovascular Diseases; Ethnicity; Female; Flour; Folic Acid; Follow-Up Studies; Food, Fortified; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Prospective Studies; Risk Factors; United States | 2012 |
Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial.
Topics: Aged; Biomarkers; Cognition; Dietary Supplements; Double-Blind Method; Folic Acid; Homocysteine; Humans; Male; Memory; Memory, Episodic; Middle Aged; Minerals; Nutritional Status; Phytotherapy; Risk Factors; Sedentary Behavior; Vitamin B 12; Vitamins | 2012 |
Vitamin B-12 supplementation of rural Mexican women changes biochemical vitamin B-12 status indicators but does not affect hematology or a bone turnover marker.
Topics: Adult; Alkaline Phosphatase; Bone Remodeling; C-Reactive Protein; Dietary Supplements; Female; Ferritins; Folic Acid; Homocysteine; Humans; Logistic Models; Methylmalonic Acid; Mexico; Middle Aged; Nutritional Status; Rural Population; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Young Adult | 2012 |
Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial.
Topics: Adipokines; Aged; Apolipoproteins; Blood Glucose; Cardiovascular Diseases; Cholesterol; Cross-Over Studies; Diet; Ethanol; Fasting; Folic Acid; Glucose; Homeostasis; Homocysteine; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Polyphenols; Risk Factors; Triglycerides; Vitamin B 12; Wine | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; India; Infant; Male; Methylmalonic Acid; Neurogenesis; Nutritional Status; Prevalence; Psychomotor Performance; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
[Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients].
Topics: Aged; Antihypertensive Agents; Arginine; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Plasma; Probucol; Vitamin B 12; Vitamin B Complex; Vitamins | 2012 |
Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation.
Topics: Adult; Dietary Supplements; Folic Acid; Glutamates; Homocysteine; Humans; Male; Urinalysis; Vitamin B 12; Vitamin B 6; Young Adult | 2013 |
The China Stroke Secondary Prevention Trial (CSSPT) protocol: a double-blinded, randomized, controlled trial of combined folic acid and B vitamins for secondary prevention of stroke.
Topics: Adult; Aged; Brain Ischemia; China; Double-Blind Method; Folic Acid; Homocysteine; Humans; Intracranial Hemorrhage, Hypertensive; Middle Aged; Myocardial Infarction; Protective Agents; Research Design; Secondary Prevention; Stroke; Vitamin B 12; Vitamin B 6 | 2015 |
Folic acid and vitamin B(12) supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Bone Remodeling; Collagen Type I; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Peptides; Placebos; Vitamin B 12 | 2013 |
Effects of mixed dietary supplements on total plasma homocysteine concentrations (tHcy): a randomized, double-blind, placebo-controlled trial.
Topics: Acute Disease; Aged; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Hospitalization; Humans; Male; Placebos; Riboflavin; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2012 |
Homocysteine and the methylenetetrahydrofolate reductase 677C-->T polymorphism in relation to muscle mass and strength, physical performance and postural sway.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Body Composition; Creatinine; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genotype; Hand Strength; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Motor Activity; Muscle, Skeletal; Polymorphism, Single Nucleotide; Postural Balance; Treatment Outcome; Vitamin B 12 | 2013 |
Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia.
Topics: Adult; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Severity of Illness Index; Tetrahydrofolates; Vitamin B Complex | 2013 |
Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters.
Topics: Adolescent; Adult; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Male; Neural Tube Defects; Northern Ireland; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Young Adult | 2013 |
Folic acid supplementation does not reduce intracellular homocysteine, and may disturb intracellular one-carbon metabolism.
Topics: Adult; Carbon; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Reference Values; Young Adult | 2013 |
Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome.
Topics: Adiponectin; Adult; Antioxidants; Beverages; Cardiovascular Diseases; Energy Intake; Female; Folic Acid; Fruit; Homocysteine; Humans; Lipid Peroxidation; Male; Metabolic Syndrome; Middle Aged; Oxidative Stress; Plant Preparations; Protein Carbonylation; Vaccinium macrocarpon | 2013 |
Vitamin B12 level may be related to the efficacy of single ketamine infusion in bipolar depression.
Topics: Adult; Aged; Bipolar Disorder; Excitatory Amino Acid Antagonists; Female; Folic Acid; Homocysteine; Humans; Infusions, Intravenous; Ketamine; Male; Middle Aged; Vitamin B 12 | 2013 |
Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors.
Topics: Adult; Apolipoprotein A-I; Atherosclerosis; Blood Pressure; Body Mass Index; Cholesterol; Chromatography, High Pressure Liquid; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Motor Activity; Risk Factors; Smoking | 2013 |
An encapsulated juice powder concentrate improves markers of pulmonary function and cardiovascular risk factors in heavy smokers.
Topics: Adult; Biomarkers; Capsules; Carbon Monoxide; Cardiovascular Diseases; Cysteine; Dietary Supplements; Female; Folic Acid; Fruit; Homocysteine; Humans; Lung; Male; Middle Aged; Plant Preparations; Powders; Respiration; Risk Factors; Smoking; Tobacco Products; Vegetables | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hydroxocobalamin; Infant; Injections, Intramuscular; Linear Models; Male; Methylmalonic Acid; Surveys and Questionnaires; Vitamin B 12 Deficiency; Vomiting | 2013 |
Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Monitoring; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Predictive Value of Tests; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2013 |
Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic syndrome after following a weight loss treatment: the RESMENA project.
Topics: Blood Glucose; Caloric Restriction; Cholesterol; Depression; Diet, Reducing; Energy Intake; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Humans; Linear Models; Longitudinal Studies; Male; Malondialdehyde; Metabolic Syndrome; Middle Aged; Oxidative Stress; Treatment Outcome; Weight Loss | 2014 |
Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans.
Topics: Adolescent; Creatine; Cysteine; Dietary Supplements; Double-Blind Method; Energy Intake; Exercise; Feeding Behavior; Folic Acid; Glycine; Healthy Volunteers; Homocysteine; Humans; Male; Methionine; S-Adenosylmethionine; Soccer; Vitamin B 12 | 2014 |
Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance.
Topics: Biomarkers; Calcium, Dietary; Child; Child, Preschool; Cognition; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Germany; Homocysteine; Humans; Male; Memory, Short-Term; Methylmalonic Acid; Vitamin B 12; Vitamin B Complex | 2014 |
Influence of dialysis techniques and alternate vitamin supplementation on homocysteine levels in patients with known MTHFR genotypes.
Topics: Adult; Aged; Aged, 80 and over; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genotype; Hemodiafiltration; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Renal Dialysis; Vitamin B 12; Vitamins; Young Adult | 2015 |
B-vitamin levels and genetics of hyperhomocysteinemia are not associated with arterial stiffness.
Topics: Aged; Aged, 80 and over; Blood Pressure; Body Mass Index; Creatinine; Cross-Sectional Studies; Double-Blind Method; Female; Folic Acid; Genotyping Techniques; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Male; Methylmalonic Acid; Multivariate Analysis; Pulse Wave Analysis; Risk Factors; Vascular Stiffness; Vitamin B 12; Vitamin B Complex | 2014 |
Supplementation of folic acid and vitamin B₁₂ reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke.
Topics: Aged; Arginine; Blood Chemical Analysis; Brain Ischemia; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Stroke; Time Factors; Treatment Outcome; Vitamin B 12 | 2014 |
Low-dose B vitamins supplementation ameliorates cardiovascular risk: a double-blind randomized controlled trial in healthy Chinese elderly.
Topics: Aged; Asian People; Blood Pressure; Body Mass Index; Cardiovascular Diseases; China; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Triglycerides; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2015 |
B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia.
Topics: Aged; Aged, 80 and over; Aging; China; Cognitive Dysfunction; Dietary Supplements; Elder Nutritional Physiological Phenomena; Female; Folic Acid; Follow-Up Studies; Homes for the Aged; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nursing Homes; Prevalence; Psychiatric Status Rating Scales; Risk Factors; Vitamin B 12; Vitamin B 6 | 2016 |
The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?
Topics: Adult; Antidepressive Agents; Carbon; Case-Control Studies; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Recurrence; Vitamin B 12; Vitamin B 6 | 2014 |
Effect of folic acid on bone metabolism: a randomized double blind clinical trial in postmenopausal osteoporotic women.
Topics: Aged; Aged, 80 and over; Biomarkers; Bone and Bones; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Osteoporosis, Postmenopausal; Vitamin B Complex | 2014 |
One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans.
Topics: Aged; Dietary Supplements; Female; Folic Acid; Germany; Homocysteine; Humans; Male; Vitamin B Complex | 2015 |
Effect of folic acid supplementation on plasma homocysteine in obese children: a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Body Mass Index; Child; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Pediatric Obesity | 2014 |
Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Endpoint Determination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Male; Motor Activity; Netherlands; Osteoporotic Fractures; Risk Factors; Treatment Outcome; Vitamin B 12 | 2014 |
Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people.
Topics: Aged; Aged, 80 and over; Biological Products; Biomarkers; Blood Glucose; C-Reactive Protein; Cholesterol; Diet; Dietary Supplements; Feeding Behavior; Female; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Humans; Inflammation; Intestines; Lactobacillus; Lactobacillus delbrueckii; Lactobacillus plantarum; Male; Oxidative Stress; Probiotics; Streptococcus thermophilus; Vitamin B 12 | 2015 |
Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma total homocysteine after folic acid supplementation: a double-blind crossover study.
Topics: Arginine; Cross-Over Studies; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Folic Acid; Gene Frequency; Genotyping Techniques; Healthy Volunteers; Homocysteine; Humans; Nitrates; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Vitamin B 6 | 2015 |
Effects of dietary folate intake on migraine disability and frequency.
Topics: Administration, Oral; Adolescent; Adult; Aged; Disabled Persons; Double-Blind Method; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Migraine Disorders; Mutation; Regression Analysis; Vitamin B Complex; Young Adult | 2015 |
Homocysteine levels after nitrous oxide anesthesia for living-related donor renal transplantation: a randomized, controlled, double-blind study.
Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Living Donors; Longitudinal Studies; Male; Middle Aged; Nitrous Oxide; Postoperative Period; Prospective Studies | 2015 |
Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh.
Topics: Adolescent; Adult; Bangladesh; Biomarkers; C-Reactive Protein; Dietary Supplements; Dose-Response Relationship, Drug; Female; Ferritins; Folic Acid; Hemoglobins; Homocysteine; Humans; Immunoglobulin A; Infant; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Lactation; Maternal Nutritional Physiological Phenomena; Methylmalonic Acid; Milk, Human; Orosomucoid; Postpartum Period; Pregnancy; Receptors, Transferrin; Vitamin B 12; Young Adult | 2016 |
Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Bone Density; Calcaneus; Dietary Supplements; Double-Blind Method; Female; Femur Neck; Folic Acid; Homocysteine; Humans; Male; Osteoporosis; Ultrasonography; Vitamin B 12 | 2015 |
Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status.
Topics: Aged; Aged, 80 and over; Antioxidants; Australia; Biomarkers; Body Mass Index; Carnosine; Cation Transport Proteins; Comet Assay; Dietary Supplements; DNA Damage; Female; Folic Acid; Gene Expression Regulation; Genomic Instability; Healthy Volunteers; Homocysteine; Humans; Male; Metallothionein; Micronutrients; Nutrition Assessment; Superoxide Dismutase; Telomere; Vitamin B 12; Zinc | 2015 |
Neuroprotective impact of a vitamin trace element composition - a randomized, double blind, placebo controlled clinical trial with healthy volunteers.
Topics: Adult; Aged; Double-Blind Method; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Lipid Peroxidation; Male; Middle Aged; Neuroprotective Agents; Pyridoxine; Superoxide Dismutase; Tocopherols; Trace Elements; Vitamin B 12; Vitamins | 2015 |
Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Asian People; Blood Pressure; Body Mass Index; Double-Blind Method; Female; Ferredoxin-NADP Reductase; Folic Acid; Folic Acid Deficiency; Genotyping Techniques; Homocysteine; Humans; Incidence; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide | 2015 |
Low-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial.
Topics: Adult; Bangladesh; Biomarkers; Cohort Studies; Creatine; Dietary Supplements; Double-Blind Method; Down-Regulation; Female; Folic Acid; Glycine; Homocysteine; Humans; Hyperhomocysteinemia; Intention to Treat Analysis; Male; Middle Aged; Patient Dropouts; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Effect of different doses of isotretinoin treatment on the levels of serum homocysteine, vitamin B 12 and folic acid in patients with acne vulgaris: A prospective controlled study.
Topics: Acne Vulgaris; Biomarkers; Case-Control Studies; Dermatologic Agents; Female; Folic Acid; Homocysteine; Humans; Isotretinoin; Male; Prospective Studies; Treatment Outcome; Turkey; Vitamin B 12; Young Adult | 2015 |
Effects of metformin plus gliclazide versus metformin plus glimepiride on cardiovascular risk factors in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Folic Acid; Gliclazide; Glycated Hemoglobin; Homocysteine; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Risk Factors; Sulfonylurea Compounds | 2015 |
A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study.
Topics: Accidental Falls; Aged; Aged, 80 and over; Aging; Dietary Supplements; Female; Folic Acid; Hand Strength; Homocysteine; Humans; Male; Motor Activity; Osteoporotic Fractures; Physical Fitness; Vitamin B 12 | 2016 |
Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
Topics: Aged; Biomarkers; China; Cognitive Dysfunction; Female; Folic Acid; Homocysteine; Humans; Male; Treatment Outcome; Vitamin B 12 | 2016 |
The C677T MTHFR genotypes influence the efficacy of B9 and B12 vitamins supplementation to lowering plasma total homocysteine in hemodialysis.
Topics: Adult; Biomarkers; Dietary Supplements; Down-Regulation; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Renal Dialysis; Time Factors; Treatment Outcome; Tunisia; Vitamin B 12; Vitamins | 2016 |
Vitamin B-12 treatment of asymptomatic, deficient, elderly Chileans improves conductivity in myelinated peripheral nerves, but high serum folate impairs vitamin B-12 status response assessed by the combined indicator of vitamin B-12 status.
Topics: Aged; Chile; Dietary Supplements; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methylmalonic Acid; Nerve Fibers, Myelinated; Neural Conduction; Nutritional Status; Peripheral Nerves; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2016 |
Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial.
Topics: Abortion, Habitual; Adult; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Iran; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Pregnancy; Tetrahydrofolates; Young Adult | 2015 |
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial.
Topics: Breast Feeding; Child Development; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infant; Infant, Low Birth Weight; Male; Methylmalonic Acid; Motor Skills; Pyridoxal Phosphate; Riboflavin; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2015 |
Folic acid supplementation reduces plasma homocysteine in postmenopausal women.
Topics: Aged; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Healthy Volunteers; Hematinics; Homocysteine; Humans; Middle Aged; Osteoporosis, Postmenopausal; Postmenopause; Risk Factors | 2016 |
Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine.
Topics: Adult; Aged; Alcohol Drinking; Atherosclerosis; Dietary Supplements; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Linear Models; Male; Middle Aged; Sarcosine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Wine | 2016 |
Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia.
Topics: Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Dietary Supplements; Double-Blind Method; Drug Combinations; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Inflammation Mediators; Male; Netherlands; Time Factors; Treatment Outcome; Vitamin B 12 | 2016 |
Phase II study of oral vitamin B12 supplementation as an alternative to intramuscular injection for patients with non-small cell lung cancer undergoing pemetrexed therapy.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Homocysteine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2016 |
Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B12 supplementation.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cystathionine; Feasibility Studies; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Intestinal Mucosa; Male; Methylmalonic Acid; Middle Aged; Neoadjuvant Therapy; Pemetrexed; Rectal Neoplasms; Rectum; Vitamin B 12 | 2016 |
Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Apolipoprotein E4; Cognition; Cognitive Dysfunction; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Genotyping Techniques; Hippocampus; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Polymorphism, Single Nucleotide; Verbal Learning; Vitamin B 12 | 2016 |
The Effect of High Dose Folic Acid throughout Pregnancy on Homocysteine (Hcy) Concentration and Pre-Eclampsia: A Randomized Clinical Trial.
Topics: Adult; Demography; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Linear Models; Pre-Eclampsia; Pregnancy; Pregnancy Outcome | 2016 |
Supplementation of vitamin B12 or folic acid on hemoglobin concentration in children 6-36 months of age: A randomized placebo controlled trial.
Topics: Anemia, Iron-Deficiency; Biomarkers; Child, Preschool; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Hemoglobins; Homocysteine; Humans; India; Infant; Infant Nutritional Physiological Phenomena; Iron, Dietary; Male; Prevalence; Receptors, Transferrin; Risk; Solubility; Urban Health; Vitamin B 12 | 2017 |
Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; China; Disease Progression; Double-Blind Method; Drug Combinations; Enalapril; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Vitamin B Complex | 2016 |
Elevated Homocysteine Concentrations Decrease the Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitors in Hypertensive Patients.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Blood Pressure; China; Double-Blind Method; Enalapril; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Time Factors; Treatment Outcome; Up-Regulation | 2017 |
Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention.
Topics: Biological Products; Cholesterol; Cholesterol, LDL; Dietary Supplements; Female; Folic Acid; Fungi; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 2016 |
Whey protein isolate improves vitamin B
Topics: Aged; Australia; Cross-Over Studies; Diet; Dietary Supplements; DNA Damage; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Nutrition Assessment; Vitamin B 12; Vitamin B 12 Deficiency; Whey Proteins | 2017 |
Folate and Vitamin B
Topics: Aged; Biomarkers; Body Mass Index; Brain; Cross-Sectional Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Linear Models; Magnetic Resonance Imaging; Male; Methylmalonic Acid; Nutritional Status; Organ Size; Tandem Mass Spectrometry; Transcobalamins; Vitamin B 12 | 2016 |
Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism.
Topics: China; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hypertension; Kaplan-Meier Estimate; Longitudinal Studies; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors | 2017 |
Homocysteine and Stroke Risk: Modifying Effect of Methylenetetrahydrofolate Reductase C677T Polymorphism and Folic Acid Intervention.
Topics: Aged; Antihypertensive Agents; China; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Folic Acid; Follow-Up Studies; Genotype; Homocysteine; Humans; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Stroke; Treatment Outcome; Vitamin B Complex | 2017 |
Interactions of Methylenetetrahydrofolate Reductase Gene Polymorphisms, Folate, and Homocysteine on Blood Pressure in a Chinese Hypertensive Population.
Topics: Blood Pressure; Folic Acid; Genotype; Homocysteine; Humans; Hypertension; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2017 |
Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults.
Topics: Aged; Body Mass Index; Diet; Dietary Supplements; Double-Blind Method; Exercise; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Socioeconomic Factors; Tetrahydrofolates; Vitamin B Complex | 2018 |
Low vitamin B
Topics: Aged; alpha-Tocopherol; beta Carotene; Carcinoma, Squamous Cell; Case-Control Studies; Dietary Supplements; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Finland; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Riboflavin; Stomach Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency | 2017 |
Effects of folic acid combined with vitamin B12 on DVT in patients with homocysteine cerebral infarction.
Topics: Adult; Aged; Cerebral Infarction; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; International Normalized Ratio; Male; Middle Aged; Recurrence; Venous Thrombosis; Vitamin B 12 | 2017 |
The effects of high and low doses of folic acid on oxidation of protein levels during pregnancy: a randomized double-blind clinical trial.
Topics: Adult; Antioxidants; Biomarkers; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Oxidation-Reduction; Oxidative Stress; Pregnancy; Proteins; Young Adult | 2017 |
Muscular contraction frequency does not affect plasma homocysteine concentration in response to energy expenditure- and intensity-matched acute exercise in sedentary males.
Topics: Adult; Anthropometry; Cross-Over Studies; Diet; Energy Metabolism; Exercise; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Muscle Contraction; Nutritional Status; Physical Endurance; Sedentary Behavior; Vitamin B 12; Vitamin B 6; Young Adult | 2018 |
Association between percent decline in serum total homocysteine and risk of first stroke.
Topics: Aged; Antihypertensive Agents; China; Drug Therapy, Combination; Enalapril; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Risk; Stroke; Vitamin B Complex | 2017 |
Maternal methyl donor supplementation during gestation counteracts bisphenol A-induced oxidative stress in sows and offspring.
Topics: Actins; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Benzhydryl Compounds; Betaine; Catalase; Choline; Diet; Dietary Supplements; Female; Folic Acid; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Malondialdehyde; Maternal Nutritional Physiological Phenomena; Oxidative Stress; Phenols; Placenta; Pregnancy; Superoxide Dismutase; Swine; Vitamin B 12 | 2018 |
B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial.
Topics: Cognition; Cognition Disorders; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; North America; Postoperative Complications; Treatment Outcome; Vitamin B Complex | 2017 |
Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Calcium Carbonate; Cholecalciferol; CpG Islands; Dietary Supplements; DNA Methylation; Double-Blind Method; Epigenesis, Genetic; Female; Folic Acid; Germany; Homocysteine; Humans; Male; Middle Aged; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2018 |
Platelet Count Affects Efficacy of Folic Acid in Preventing First Stroke.
Topics: Aged; China; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hypertension; Male; Middle Aged; Platelet Count; Stroke; Treatment Outcome; Vitamin B Complex | 2018 |
Effect of Combined Treatment With Folic Acid, Vitamin B
Topics: Aged; Biomarkers; Cardiovascular Diseases; Double-Blind Method; Drug Combinations; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Inflammation; Inflammation Mediators; Middle Aged; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamins | 2018 |
Cobalamin and Folate Status among Breastfed Infants in Bhaktapur, Nepal.
Topics: Biomarkers; Breast Feeding; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant; Infant Nutritional Physiological Phenomena; Male; Methylmalonic Acid; Nepal; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
Assessment of Serum Folic Acid and Homocysteine in Thalassemia Major Patients Before and After Folic Acid Supplement Cessation.
Topics: Adolescent; Adult; beta-Thalassemia; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Iran; Male; Withholding Treatment; Young Adult | 2018 |
Rehydration during exercise prevents the increase of homocysteine concentrations.
Topics: Adult; Creatine; Creatinine; Cross-Over Studies; Drinking Water; Exercise; Fluid Therapy; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Isotonic Solutions; Male; Methylenetetrahydrofolate Reductase (NADPH2); Vitamin B 12; Young Adult | 2019 |
Effect of long-term low-dose folic acid supplementation on degree of total homocysteine-lowering: major effect modifiers.
Topics: Aged; China; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Genotype; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Smoking; Stroke | 2018 |
The Effect of Whey and Soy Protein Isolates on Cognitive Function in Older Australians with Low Vitamin B
Topics: Aged; Australia; Cognition; Cross-Over Studies; Female; Folic Acid; Homocysteine; Humans; Male; Memory; Methylmalonic Acid; Middle Aged; Nutritional Status; Reaction Time; Sex Factors; Soybean Proteins; Vitamin B 12; Vitamin B 12 Deficiency; Whey Proteins | 2018 |
Effect of a weight-loss stabilization following a weight reduction with or without meal replacement on cardiometabolic risk in overweight women. A randomized controlled trial.
Topics: Adult; Anthropometry; Cardiovascular Diseases; Diet, Reducing; Female; Folic Acid; Homocysteine; Humans; Meals; Metabolic Syndrome; Middle Aged; Overweight; Waist Circumference; Weight Loss | 2019 |
Plasma retinol and the risk of first stroke in hypertensive adults: a nested case-control study.
Topics: Aged; Antihypertensive Agents; Brain Ischemia; Case-Control Studies; China; Double-Blind Method; Enalapril; Female; Folic Acid; Hemorrhage; Homocysteine; Humans; Hypertension; Male; Middle Aged; Odds Ratio; Primary Prevention; Risk Factors; Stroke; Vitamin A; Vitamin A Deficiency | 2019 |
Effect of folic acid supplementation on nerve conduction velocity in diabetic polyneuropathy patients.
Topics: Adult; Diabetic Neuropathies; Dietary Supplements; Double-Blind Method; Electromyography; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neural Conduction; Reaction Time; Severity of Illness Index; Statistics, Nonparametric; Vitamin B 12 | 2019 |
Potential of the multivitamin-mineral-trace element composition LaVita® before, during and after pregnancy.
Topics: Biomarkers; Dietary Supplements; Double-Blind Method; Female; Ferritins; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Iron; Male; Prospective Studies; Sex Factors; Time Factors; Vitamin B 12; Vitamin B 6; Zinc | 2019 |
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia.
Topics: Adolescent; Adult; Betaine; Dietary Supplements; Female; Folic Acid; Gambia; Homocysteine; Humans; Middle Aged; Nutritional Status; Riboflavin; Vitamin B 12; Young Adult | 2019 |
Dietary intakes and biomarker patterns of folate, vitamin B
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cognitive Dysfunction; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Pyrophosphatases; Thioredoxin Reductase 1; Vitamin B 12; Vitamin B 6 | 2019 |
A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients.
Topics: Aged; Aged, 80 and over; Cognition; Cognitive Dysfunction; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Treatment Outcome; Vitamin B 12; Vitamin B Complex | 2020 |
Infantile Tremor Syndrome or a Neurocutaneous Infantile B12 Deficiency (NIB) Syndrome?
Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Erythrocyte Indices; Female; Folic Acid; Homocysteine; Humans; India; Male; Malnutrition; Methylmalonic Acid; Mothers; Prospective Studies; Tremor; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2020 |
The effect of folic acid throughout pregnancy among pregnant women at high risk of pre-eclampsia: A randomized clinical trial.
Topics: Adult; Apgar Score; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hypertension, Pregnancy-Induced; Infant, Newborn; Pre-Eclampsia; Pregnancy; Secondary Prevention; Vitamin B Complex | 2020 |
Vitamin B
Topics: Child; Child Development; Cognition; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; India; Intelligence Tests; Language Development; Male; Vitamin B 12; Vitamin B Complex | 2020 |
The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C-reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo-controlled clinical t
Topics: C-Reactive Protein; Chronic Periodontitis; Dental Scaling; Folic Acid; Gingival Crevicular Fluid; Homocysteine; Humans; Periodontitis; Root Planing | 2020 |
[Bioavailability of natural versus synthetic B vitamins and their effects on metabolic processes].
Topics: Biological Availability; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Pilot Projects; Vitamin B 12; Vitamin B Complex; Vitamins | 2020 |
Association of antenatal vitamin B complex supplementation with neonatal vitamin B
Topics: China; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Pregnancy; Vitamin B 12; Vitamin B Complex | 2021 |
Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial.
Topics: Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Fractures, Bone; Homocysteine; Humans; Male; Odds Ratio; Osteoporotic Fractures; Placebos; Risk Factors; Vitamin B 12 | 2021 |
Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults.
Topics: Adult; Arsenic; Betaine; Choline; Creatine; Dietary Supplements; Environmental Exposure; Folic Acid; Homocysteine; Humans; Methylation | 2021 |
Responsiveness of one-carbon metabolites to a high-protein diet in older men: Results from a 10-wk randomized controlled trial.
Topics: Aged; Betaine; Carbon; Choline; Diet; Diet, High-Protein; Folic Acid; Homocysteine; Humans; Male; Vitamin B Complex | 2021 |
Effects of vitamin B12, folate, and entacapone on homocysteine levels in levodopa-treated Parkinson's disease patients: A randomized controlled study.
Topics: Aged; Antiparkinson Agents; Catechols; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Research Design; Vitamin B 12 | 2021 |
Parkinson's disease: Research puts spotlight on thiamine deficiency and cardiovascular health.
Topics: Folic Acid; Homocysteine; Humans; Levodopa; Parkinson Disease; Thiamine Deficiency; Vitamin B 12 | 2021 |
Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal.
Topics: Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Nepal; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial.
Topics: Aged; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Vitamin B 12; Vitamins | 2021 |
Effects of individualized administration of folic acid on prothrombotic state and vascular endothelial function with H-type hypertension: A double-blinded, randomized clinical cohort study.
Topics: Amlodipine; Cohort Studies; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Precision Medicine; Vascular Endothelial Growth Factor A | 2022 |
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B
Topics: Adult; Aged; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Postmenopause; Vitamin B 12; Vitamins; Zinc | 2022 |
Adolescent Afghan Refugees Display a High Prevalence of Hyperhomocysteinemia and Associated Micronutrients Deficiencies Indicating an Enhanced Risk of Cardiovascular Disease in Later Life.
Topics: Adolescent; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Malnutrition; Micronutrients; Prevalence; Refugees; Vitamin B 12 | 2022 |
DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial.
Topics: Aged; Cognition; Cognitive Aging; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B Complex | 2022 |
Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients.
Topics: Adaptor Proteins, Vesicular Transport; Blood Glucose; Diabetes Mellitus, Type 2; Folic Acid; Glycemic Control; Homocysteine; Humans; Insulin Resistance; Lipids | 2022 |
B Vitamin Supplementation Slows Cognitive Decline in Mild Cognitive Impairment Patients with Frontal Lobe Atrophy.
Topics: Aspirin; Atrophy; Cognition; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Frontal Lobe; Homocysteine; Humans; Vitamin B 12; Vitamin B Complex | 2022 |
Optimum dose of oral folic acid supplementation in transfusion-dependent thalassemia: a randomized controlled trial.
Topics: Child; Dietary Supplements; Folic Acid; Homocysteine; Humans; Thalassemia | 2022 |
Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease.
Topics: Coronary Artery Disease; Fibrin; Folic Acid; Homocysteine; Humans; Myocardial Infarction; Prognosis; Risk Factors; Thrombosis; Vitamin B 12; Vitamin B Complex | 2022 |
Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial.
Topics: Adolescent; Adult; Aged; Betaine; Dietary Supplements; Double-Blind Method; East Asian People; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Vitamin B 12; Vitamin B Complex; Young Adult | 2023 |
Daily Folic Acid and/or Vitamin B12 Supplementation Between 6 and 30 Months of Age and Cardiometabolic Risk Markers After 6-7 Years: A Follow-Up of a Randomized Controlled Trial.
Topics: Adiponectin; Child; Child, Preschool; Dietary Supplements; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Leptin; Vitamin B 12 | 2023 |
Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized,
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Double-Blind Method; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Stroke; Treatment Outcome | 2023 |
2758 other study(ies) available for homocysteine and folic acid
| Article | Year |
|---|---|
Vitamin B12--folate interrelations.
Topics: Anemia, Megaloblastic; DNA; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Glycine; Homocysteine; Humans; Methionine; Methylmalonyl-CoA Mutase; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1976 |
High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma 256, Walker; Cell Line; Cell Transformation, Neoplastic; Folic Acid; Homocysteine; Methionine; Simian virus 40 | 1976 |
5-methyltetrahydrofolate: synthesis and utilization in normal and SV40-transformed BHK-21 cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cricetinae; Folic Acid; Homocysteine; Kidney; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Simian virus 40; Tetrahydrofolates; Vitamin B 12 | 1977 |
Plasmodium knowlesi: in vitro biosynthesis of methionine and thymidylic acid.
Topics: Animals; Betaine; Cells, Cultured; Choline; Erythrocytes; Folic Acid; Formaldehyde; Formyltetrahydrofolates; Haplorhini; Histidine; Homocysteine; Macaca mulatta; Methionine; Plasmodium; Sarcosine; Serine; Thymidine Monophosphate; Thymine Nucleotides | 1977 |
Effect of DL-homocysteine on some hepatic folate enzymes and folate concentration in cobalamin-deficient rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alcohol Oxidoreductases; Animals; Diet; Folic Acid; Homocysteine; Liver; Male; Methyltransferases; Rats; Tetrahydrofolates; Vitamin B 12 Deficiency | 1978 |
The regulation of the degradation of methionine and of the one-carbon units derived from histidine, serine and glycine.
Topics: Animals; Carbon Dioxide; Enzyme Activation; Folic Acid; Formates; Formiminoglutamic Acid; Gluconeogenesis; Glucose; Glycine; Histidine; Homocysteine; In Vitro Techniques; Liver; Methionine; Oxidoreductases Acting on CH-NH Group Donors; Perfusion; Rats; Serine; Tetrahydrofolates | 1976 |
Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity.
Topics: Adolescent; Alcohol Oxidoreductases; Diagnosis, Differential; Female; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Methionine; Methylation; Schizophrenia; Tetrahydrofolates; Vitamin B 12 | 1975 |
Folate-dependent enzymes in cultured Chinese hamster ovary cells: induction of 5-methyltetrahydrofolate homocysteine cobalamin methyltransferase by folate and methionine.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Culture Media; Cycloheximide; Enzyme Induction; Folic Acid; Homocysteine; Kinetics; Methionine; Methyltransferases; Thymidylate Synthase; Time Factors; Vitamin B 12 | 1975 |
The anti-folate effect of methionine on bone marrow of normal and vitamin B12 deficient rats.
Topics: Animals; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methionine; Methionine Adenosyltransferase; Rats; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1975 |
Methionine metabolism in BHK cells: selection and characterization of ethionine resistant clones.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Clone Cells; Drug Resistance; Ethionine; Folic Acid; Homocysteine; Methionine; Methionine Adenosyltransferase; Mutation; Norleucine; Quinone Reductases; Selenomethionine; Vitamin K | 1976 |
Effect of vitamin B12 and folate on biosynthesis of methionine from homocysteine in the nematode Caenorhabditis briggsae.
Topics: Animals; Choline; Folic Acid; Homocysteine; Methionine; Nematoda; Vitamin B 12 | 1976 |
Plasma homocysteine in women on oral oestrogen-containing contraceptives and in men with oestrogen-treated prostatic carcinoma.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Contraceptives, Oral, Hormonal; Estradiol Congeners; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Prostatic Neoplasms; Risk Factors; Vitamin B 12 | 1992 |
Plasma folate adequacy as determined by homocysteine level.
Topics: Adult; Arterial Occlusive Diseases; Biological Assay; Biomarkers; Chromatography, High Pressure Liquid; Coronary Disease; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Reference Values | 1992 |
Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication.
Topics: Aged; Exercise Test; Folic Acid; Homocysteine; Homocystine; Humans; Intermittent Claudication; Lipids; Logistic Models; Male; Middle Aged; Risk Factors | 1992 |
Synthesis and biological activity of novel folic acid analogues: pteroyl-S-alkylhomocysteine sulfoximines.
Topics: Animals; Antineoplastic Agents; Cell Division; Folic Acid; Homocysteine; Leukemia L1210; Methionine Sulfoximine; Mice; Molecular Structure; Pterins; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1992 |
Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status.
Topics: Adult; Aged; Aging; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Menopause; Methionine; Middle Aged; Pyridoxal Phosphate; Sex Characteristics; Vascular Diseases; Vitamin B 12 | 1992 |
Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Cerebrovascular Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxal Phosphate; Risk Factors; Vitamin B 12 | 1992 |
Homocysteine remethylation during nitrous oxide exposure of cells cultured in media containing various concentrations of folates.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Mice; Nitrous Oxide; Tetrahydrofolates | 1992 |
Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Folic Acid; Homocysteine; Male; Methionine; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Nitrous Oxide; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Succinates; Succinic Acid; Vitamin B 12 | 1991 |
Plasma homocysteine in venous thromboembolism.
Topics: Adult; Creatinine; Cystathionine beta-Synthase; Fasting; Female; Folic Acid; Genetic Carrier Screening; Genotype; Homocysteine; Homocystinuria; Humans; Male; Methionine; Thromboembolism; Vitamin B 12 | 1991 |
Homocysteine content of plasma in ischemic heart disease, the reducing effect of pyridoxine, folate, cobalamin, choline, riboflavin and troxerutin. Correction of a calculation error.
Topics: Amino Acids; Anticoagulants; Choline; Coronary Disease; Folic Acid; Homocysteine; Humans; Hydroxyethylrutoside; Pyridoxine; Riboflavin; Vitamin B 12 | 1991 |
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1991 |
Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations.
Topics: Adolescent; Adult; Alleles; Amino Acid Metabolism, Inborn Errors; Enzyme Activation; Female; Folic Acid; Heterozygote; Homocysteine; Hot Temperature; Humans; Infant, Newborn; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pedigree; Substrate Specificity; Vitamin B 12 | 1991 |
Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthesia, Intravenous; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Nitrous Oxide; Postoperative Period; Vitamin B 12 | 1991 |
Serum homocysteine in routine evaluation of potential vitamin B12 and folate deficiency.
Topics: Adult; Erythrocyte Indices; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Reference Values; Vitamin B 12 Deficiency | 1990 |
Diagnosis of cobalamin deficiency I: usefulness of serum methylmalonic acid and total homocysteine concentrations.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Reference Values; Vitamin B 12 Deficiency | 1990 |
Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations.
Topics: Adult; Aged; Celiac Disease; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Intestines; Male; Methylmalonic Acid; Middle Aged; Reference Values; Vitamin B 12; Vitamin B 12 Deficiency | 1990 |
Clinical spectrum and diagnosis of cobalamin deficiency.
Topics: Bilirubin; Female; Folic Acid; Gastrins; Hematocrit; Homocysteine; Humans; L-Lactate Dehydrogenase; Male; Methylmalonic Acid; Prospective Studies; Reference Values; Vitamin B 12; Vitamin B 12 Deficiency | 1990 |
Homocysteinemia in rats induced by folic acid deficiency.
Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; Homocysteine; Male; Rats; Rats, Inbred Strains | 1989 |
Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis.
Topics: Adult; Anticoagulants; Choline; Coronary Artery Disease; Coronary Disease; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Hydroxyethylrutoside; Lipids; Male; Middle Aged; Pyridoxine; Riboflavin; Vitamin B 12 | 1989 |
Cobalamin inactivation decreases purine and methionine synthesis in cultured human lymphoblasts.
Topics: Folic Acid; Homocysteine; Humans; Lymphocytes; Methionine; Nitrous Oxide; Oxidation-Reduction; Purines; Serine; Vitamin B 12 | 1986 |
Homocysteinemia: depressed plasma serine levels.
Topics: Adult; Betaine; Carbon-Oxygen Lyases; Child, Preschool; Folic Acid; Glycine; Homocysteine; Humans; Isoleucine; Kidney Transplantation; Lyases; Male; Serine | 1987 |
The total serum homocysteine as an indicator of vitamin B12 and folate status.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Aged; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Humans; Hydrolases; Infant; Male; Middle Aged; Reference Standards; Tritium; Vitamin B 12 | 1988 |
Accumulation of homocysteine in rats fed diets deficient in folic acid.
Topics: Animals; Folic Acid; Folic Acid Deficiency; Homocysteine; Male; Rats; Rats, Inbred Strains | 1988 |
Folic acid--an innocuous means to reduce plasma homocysteine.
Topics: Adult; Amino Acids; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Vitamin B 12 | 1988 |
Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease.
Topics: Adult; Creatinine; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Vascular Diseases | 1988 |
Homocysteinemia due to folate deficiency.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Pregnancy; Protein Binding | 1987 |
Folic acid responsive postmenopausal homocysteinemia.
Topics: Adult; Aging; Cystine; Dipeptides; Fasting; Female; Folic Acid; Glycine; Homocysteine; Humans; Male; Menopause; Methionine; Middle Aged; Serine | 1985 |
Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients.
Topics: Adolescent; Adult; Betaine; Child; Cystathionine beta-Synthase; Cysteine; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Male; Methionine; Middle Aged; Pyridoxine; Serine | 1985 |
Ethanol, the choline requirement, methylation and liver injury.
Topics: Animals; Betaine; Choline; Ethanol; Folic Acid; Homocysteine; Liver; Methionine; Methylation; Rats; Tetrahydrofolates | 1985 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
A study of the behavioral disruption of mice induced by l-methionine and related compounds.
Topics: Amphetamine; Animals; Behavior, Animal; Betaine; Chlorpromazine; Cystathionine; Folic Acid; Histidine; Homocysteine; Homoserine; Male; Mescaline; Methionine; Mice; N,N-Dimethyltryptamine; Niacinamide; Serine; Social Behavior | 1974 |
Methyl derivatives of folic acid as intermediates in the methylation of homocysteine by Escherichia coli.
Topics: Alkylation; Chromatography; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; In Vitro Techniques; Methionine; Molecular Biology; Mutation; NAD | 1964 |
Methionine biosynthesis in Ochromonas malhamensis.
Topics: Adenosine Triphosphate; Alcohols; Carbon Isotopes; Cyanides; Enzyme Activation; Eukaryota; Flavin Mononucleotide; Folic Acid; Homocysteine; Kinetics; Light; Magnesium; Methionine; NAD; Oxygen; Sulfur; Transferases; Vitamin B 12 | 1969 |
Formation of the N5-methyltetrahydrofolate-homocysteine methyltransferase holoenzyme from apoenzyme and adenosyl-B 12.
Topics: Adenine Nucleotides; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Enzyme Precursors; Escherichia coli; Folic Acid; Homocysteine; Methionine; NAD; Transferases; Vitamin B 12 | 1970 |
Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.
Topics: Adenosine; Alcohol Oxidoreductases; Ammonium Sulfate; Animals; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Drug Stability; Flavin-Adenine Dinucleotide; Folic Acid; Formaldehyde; Homocysteine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Liver; NAD; NADP; Rats; S-Adenosylmethionine; Spectrophotometry; Swine; Vitamin K | 1971 |
The effect of DL-methionine, vitamin B 12, and thyroid powder on metabolism of formiminoglutamic acid in rats.
Topics: Animals; Azo Compounds; Body Weight; Diet; FIGLU Test; Folic Acid; Folic Acid Deficiency; Glutarates; Growth; Homocysteine; Liver; Male; Methionine; Methods; Rats; Tetrahydrofolates; Thyroid (USP); Thyroid Hormones; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
N-5,10-methylenetetrahydrofolate reductase deficiency and schizophrenia: a working hypothesis.
Topics: Adolescent; Dopamine; Female; Fibroblasts; Folic Acid; Homocysteine; Humans; Male; Metabolism, Inborn Errors; Methylation; Methylenetetrahydrofolate Dehydrogenase (NADP); Methyltransferases; Oxidoreductases; Schizophrenia; Tetrahydrofolates | 1974 |
Regulation of 5-methyltetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells.
Topics: Animals; Cells, Cultured; Cricetinae; Folic Acid; Homocysteine; Kidney; Mercaptoethanol; Methionine; Methyltransferases; Puromycin; Tetrahydrofolates; Vitamin B 12 | 1973 |
Effect of methionine and vitamin B-12 on the activities of methionine biosynthetic enzymes in metJ mutants of Escherichia coli K12.
Topics: Adenosine Triphosphate; Culture Media; Cystathionine; Enzyme Repression; Escherichia coli; Folic Acid; Homocysteine; Hydro-Lyases; L-Serine Dehydratase; Methionine; Methyltransferases; Mutation; Oxidoreductases; S-Adenosylmethionine; Time Factors; Transferases; Vitamin B 12 | 1973 |
Folic acid and the methylation of homocysteine by Bacillus subtilis.
Topics: Alcohol Oxidoreductases; Bacillus subtilis; Chromatography, Gel; Chromatography, Thin Layer; Cobamides; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Serine; Ultrasonics; Vitamin B 12 | 1972 |
Homocystinuria. Reduced folate levels during pyridoxine treatment.
Topics: Child; Child, Preschool; Cystine; Erythrocytes; Female; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Infant; Male; Metabolic Diseases; Methionine; Methyltransferases; Pyridoxine | 1973 |
Effect of methionine on specific folate coenzyme pools in vitamin B 12 deficient and supplemented rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Carbon Isotopes; Chromatography, DEAE-Cellulose; Coenzymes; FIGLU Test; Folic Acid; Glutamates; Homocysteine; Liver; Male; Malonates; Methionine; Methyltransferases; Oligopeptides; Rats; Tetrahydrofolates; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
[Importance and regulation of the cobalamin-dependent methionine synthetase and the betaine: homocystein methyltransferase in methionine and tetrahydrofolic acid metabolism of the rat].
Topics: Animals; Betaine; Coenzyme A; Diet; Female; Folic Acid; Homocysteine; Kidney; Liver; Methionine; Methylation; Methyltransferases; Rats; Tetrahydrofolates; Vitamin B 12 | 1973 |
The utilization of formate by human erythrocytes.
Topics: Alcohol Oxidoreductases; Biological Assay; Carbon Isotopes; Erythrocytes; Folic Acid; Formates; Homocysteine; Humans; Imidazoles; Lactobacillus; Ligases; Methyltransferases; Oxidoreductases; Streptomyces; Tetrahydrofolates; Transferases | 1973 |
Enzymic synthesis of methionine: formation of a radioactive cobamide enzyme with N5-methyl-14C-tetrahydrofolate.
Topics: Carbon Isotopes; Catalysis; Chromatography, Gel; Escherichia coli; Folic Acid; Homocysteine; Kinetics; Methionine; Methylation; Transferases; Vitamin B 12 | 1967 |
Escherichia coli B N5-methyltetrahydrofolate-homocysteine vitamin-B12 transmethylase: formation and photolability of a methylcobalamin enzyme.
Topics: Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Chromatography, Paper; Drug Stability; Electrophoresis; Escherichia coli; Folic Acid; Homocysteine; Hydrogen-Ion Concentration; Light; Models, Biological; Oxidation-Reduction; Paper; Spectrophotometry; Transferases; Vitamin B 12 | 1968 |
Chemical propylation of vitamin-B12 transmethylase: anomalous behavior of S-adenosyl-L-methionine.
Topics: Adenine Nucleotides; Alkylation; Carbon Isotopes; Escherichia coli; Flavins; Folic Acid; Homocysteine; Methionine; Models, Chemical; Serum Albumin, Bovine; Sulfhydryl Compounds; Transferases; Vitamin B 12 | 1968 |
Binding of substrate to N5-methyl-tetrahydroteroyl-triglutamate-homocysteine transmethylase.
Topics: Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Escherichia coli; Folic Acid; Gels; Homocysteine; Methionine; Transferases | 1968 |
Escherichia coli B N5-methyltetrahydrofolate-homocysteine methyltransferase: sequential formation of bound methylcobalamin with S-adenosyl-L-methionine and N5-methyltetrahydrofolate.
Topics: Carbon Isotopes; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Escherichia coli; Folic Acid; Homocysteine; Light; Methionine; Methylation; Nucleosides; Temperature; Time Factors; Transferases; Vitamin B 12 | 1969 |
Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: activation with S-adenosyl-L-methionine and the mechanism for methyl group transfer.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Models, Biological; Nucleosides; Time Factors; Transferases; Vitamin B 12 | 1969 |
The substrate specificity of 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase.
Topics: Escherichia coli; Folic Acid; Glutamates; Homocysteine; Methionine; Methylation; Neurospora; Saccharomyces; Transferases | 1969 |
On the role of S-adenoxylmethionine in the vitamin B12 dependent methionine biosynthesis.
Topics: Alcohols; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Escherichia coli; Flavin Mononucleotide; Folic Acid; Homocysteine; Hydroxyapatites; Kinetics; Methionine; Methods; Methylation; Nucleosides; Spectrophotometry; Sulfur; Transferases; Vitamin B 12 | 1969 |
Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase.
Topics: Carbon Isotopes; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Culture Media; Electrophoresis, Disc; Enzyme Repression; Escherichia coli; Folic Acid; Homocysteine; Magnesium; Mathematics; Methionine; Methods; Molecular Weight; Mutation; Peptides; Protamines; Quaternary Ammonium Compounds; Spectrophotometry; Transferases; Ultracentrifugation; Ultraviolet Rays; Vibration | 1970 |
Binding of the folate substrate to 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase.
Topics: Benzoates; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Escherichia coli; Folic Acid; Glutamates; Homocysteine; Mutation; Peptides; Pteridines; Temperature; Time Factors; Transferases | 1970 |
Escherichia coli B 5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: catalysis by a reconstituted methyl-14C-cobalamin holoenzyme and the function of S-adenosyl-l-methionine.
Topics: Carbon Isotopes; Escherichia coli; Flavin Mononucleotide; Folic Acid; Homocysteine; Hydrogen; Kinetics; Methionine; Nucleosides; Oxygen; Protein Binding; Transferases; Vitamin B 12 | 1970 |
Spectrophotometric evidence for the formation of an Escherichia coli B B-12s methyltransferase.
Topics: Alcohols; Carbon Isotopes; Escherichia coli; Folic Acid; Free Radicals; Homocysteine; Hydrogen-Ion Concentration; Iodides; Ligases; Methionine; Methylation; Oxidation-Reduction; Spectrophotometry; Sulfur; Transferases; Ultraviolet Rays; Vitamin B 12 | 1970 |
The vitamin B12-dependent methionine synthetase. The cycle of transmethylation.
Topics: Enzyme Induction; Escherichia coli; Folic Acid; Homocysteine; Methionine; Methylation; Methyltransferases; Nucleosides; Oxidation-Reduction; Spectrophotometry; Transferases; Vitamin B 12 | 1971 |
Methylcobalamin as a substrate at a separate site on Escherichia coli B N 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase.
Topics: Alkylation; Binding Sites; Carbon Isotopes; Catalysis; Coenzymes; Electrophoresis; Electrophoresis, Disc; Escherichia coli; Folic Acid; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Methylation; Methyltransferases; Temperature; Tritium; Urea; Vitamin B 12 | 1971 |
Vitamin B 12 and methionine synthesis in Escherichia coli.
Topics: Acyltransferases; Aerobiosis; Alcohol Oxidoreductases; Anilides; Carbon Isotopes; Chromatography, Ion Exchange; Enzyme Repression; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Genetics, Microbial; Homocysteine; Homoserine; Kinetics; Methionine; Methyltransferases; Mutation; Serine; Succinates; Transferases; Vitamin B 12 | 1971 |
Escherichia coli B N 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase: gel-filtration behavior of apoenzyme and holoenzymes.
Topics: Alkylation; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Dithiothreitol; Drug Stability; Escherichia coli; Folic Acid; Homocysteine; Hydroxocobalamin; Macromolecular Substances; Mathematics; Methylation; Methyltransferases; Molecular Weight; Tritium; Urea; Vitamin B 12 | 1971 |
Homocysteine-dependent transmethylases catalyzing the synthesis of methionine in germinating pea seeds.
Topics: Chromatography, Gel; Edetic Acid; Folic Acid; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Methionine; Neurospora; Nucleosides; Plants; Saccharomyces; Seeds; Transferases | 1970 |
Total synthesis of acetate from CO 2 : methyltetrahydrofolate, an intermediate, and a procedure for separation of the folates.
Topics: Acetates; Animals; Biological Assay; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Chromatography, Ion Exchange; Clostridium; Culture Media; Electron Transport; Enterococcus faecalis; Enzymes; Folic Acid; Freeze Drying; Glutamates; Homocysteine; Hydrolysis; Kidney; Methionine; Methods; Methyltransferases; Swine | 1971 |
Methionine or folate and phosphoenolpyruvate in the biosynthesis of threonine in Crithidia fasciculata.
Topics: Alanine; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Culture Media; Cystine; Eukaryota; Folic Acid; Homocysteine; Homoserine; Hydrazones; Hydroxybutyrates; Keto Acids; Methionine; Methyltransferases; Phosphoenolpyruvate; Sulfonic Acids; Sulfur Isotopes; Threonine | 1972 |
Homocystinuria associated with decreased methylenetetrahydrofolate reductase activity.
Topics: Adolescent; Carbon Isotopes; Coenzymes; Female; Fibroblasts; Folic Acid; Homocysteine; Homocystinuria; Humans; L-Serine Dehydratase; Male; Methionine; Methylation; Methyltransferases; Oxidoreductases; Vitamin B 12 | 1972 |
The isolation of N 5 -methyltetrahydrofolate-homocysteine transmethylase from bovine brain.
Topics: Ammonium Sulfate; Animals; Brain; Carbon Isotopes; Cattle; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Disc; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Kidney; Liver; Methyltransferases; Organ Specificity; Protamines; S-Adenosylmethionine; Spectrophotometry | 1972 |
An assay for N 5 -methyltetrahydrofolate-homocysteine transmethylase activity using instant thin-layer chromatography.
Topics: Animals; Carbon Isotopes; Chromatography, Thin Layer; Folic Acid; Formaldehyde; Homocysteine; Kidney; Methionine; Methylation; Methyltransferases; S-Adenosylmethionine | 1972 |
The effect of methionine on folic acid and histidine metabolism in perfused rat liver.
Topics: Animals; Betaine; Carbon Dioxide; Carbon Isotopes; Choline; Deficiency Diseases; Drug Synergism; Ethionine; Folic Acid; Formates; Glutamates; Histidine; Homocysteine; Liver; Male; Methionine; Oxidation-Reduction; Peptides; Perfusion; Rats; Tetrahydrofolates; Vitamin B 12 Deficiency | 1972 |
Combined vitamin responsiveness in homocystinuria.
Topics: Adolescent; Adult; Amino Acids; Child; Drug Synergism; Female; Folic Acid; Folic Acid Deficiency; Glycine; Homocysteine; Homocystinuria; Humans; L-Serine Dehydratase; Male; Metabolic Diseases; Methionine; Methylation; Pyridoxine; Vitamin B 12 | 1972 |
Isolation of a cobalamin containing 5-methyltetrahydrofolate-homocysteine transmethylase from mammalian kidney.
Topics: Ammonium Sulfate; Animals; Calcium Phosphates; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Drug Stability; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Kidney; Methods; Methyltransferases; Protamines; S-Adenosylmethionine; Spectrophotometry; Sulfuric Acids; Swine; Ultraviolet Rays; Vitamin B 12 | 1971 |
Mechanism of mammalian cobalamin-dependent methionine biosynthesis.
Topics: Alkylation; Animals; Carbon Isotopes; Darkness; Dithiothreitol; Electrophoresis, Disc; Enzyme Activation; Flavin Mononucleotide; Folic Acid; Homocysteine; Hydroxocobalamin; Iodides; Kidney; Kinetics; Light; Mathematics; Mercaptoethanol; Methionine; Methylation; Methyltransferases; Models, Biological; Models, Chemical; Oxidation-Reduction; Radiation Effects; S-Adenosylmethionine; Swine; Tritium | 1971 |
Defective metabolism of vitamin B 12 in fibroblasts from children with methylmalonicaciduria.
Topics: Adolescent; Adult; Cells, Cultured; Child; Child, Preschool; Cobalt Isotopes; Deoxyadenosines; Enzyme Activation; Fibroblasts; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Infant; Infant, Newborn; Male; Malonates; Metabolism, Inborn Errors; Methylation; Methyltransferases; Vitamin B 12 | 1971 |
Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli.
Topics: Adenosine Triphosphate; Alkylation; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; In Vitro Techniques; Kinetics; Magnesium | 1964 |
[Pernicious anemia--funicular spinal disease--pernicious psychosis].
Topics: Anemia, Pernicious; Female; Folic Acid; Homocysteine; Humans; Intestinal Absorption; Isomerases; Methionine; Middle Aged; Neurocognitive Disorders; Spinal Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1969 |
Vitamin B 12 dependent methionine biosynthesis in cultured mammalian cells.
Topics: Animals; Carbon Isotopes; Carcinoma; Cell Division; Cell Line; Cricetinae; Culture Media; Culture Techniques; Drug Synergism; Folic Acid; Formaldehyde; HeLa Cells; Homocysteine; Humans; Kidney; Laryngeal Neoplasms; Methionine; Stimulation, Chemical; Swine; Transferases; Vitamin B 12 | 1969 |
Methylcobalamin as an intermediate in mammalian methionine biosynthesis.
Topics: Animals; Carbon Isotopes; Chromatography, Gel; Electrophoresis; Ethanol; Folic Acid; Homocysteine; Kidney; Methionine; Methylation; Nucleosides; Photochemistry; Solubility; Swine; Transferases; Vitamin B 12 | 1970 |
Methylation of homocysteine in Coprinus lagopus.
Topics: Basidiomycota; Folic Acid; Homocysteine; Methionine; Methylation; Serine; Transferases | 1970 |
Hydrocarbon-utilizing microorganism. Relationship of fatty acid composition and biosynthesis to hydrocarbon substrate and to vitamin B 12 level in Corynebacterium simplex.
Topics: Alkanes; Carbon Isotopes; Cobalt; Corynebacterium; Culture Media; Fatty Acids; Folic Acid; Homocysteine; Methionine; Methylation; Nucleosides; Spectrum Analysis; Transferases; Vitamin B 12 | 1970 |
Deranged B 12 metabolism: effects on sulfur amino acid metabolism.
Topics: Adenosine Triphosphate; Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Betaine; Brain Chemistry; Carbon Isotopes; Child, Preschool; Folic Acid; Homocysteine; Humans; Infant; Infant, Newborn; Isomerases; Kidney; Liver; Male; Malonates; Methionine; Methyltransferases; Transferases; Vitamin B 12 | 1970 |
Deranged B 12 metabolism: studies of fibroblasts grown in tissue culture.
Topics: Amino Acid Metabolism, Inborn Errors; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Fibroblasts; Folic Acid; Glutamates; Homocysteine; Humans; Hydroxocobalamin; Isomerases; L-Serine Dehydratase; Male; Malonates; Methionine; Methyltransferases; Propionates; Skin; Vitamin B 12 | 1970 |
Homocystinuria with methylmalonic aciduria: two cases in a sibship.
Topics: Adolescent; Carbon Isotopes; Child, Preschool; Coenzyme A; Female; Fibroblasts; Folic Acid; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Isomerases; L-Serine Dehydratase; Male; Malonates; Methionine; Methyltransferases; Pedigree; Propionates; Skin; Vitamin B 12 | 1970 |
Studies on vitamin B12 metabolism in HeLa cells.
Topics: Adenosine Triphosphate; Carbon Dioxide; Carbon Isotopes; Cell Line; Coenzyme A; Culture Techniques; Enzyme Activation; Folic Acid; HeLa Cells; Homocysteine; Isomerases; Malonates; Methionine; Propionates; Transferases; Vitamin B 12 | 1971 |
[The role of vitamin B12 in metabolism].
Topics: Animals; Coenzymes; Folic Acid; Homocysteine; Humans; Isomerases; Methylation; Vitamin B 12; Vitamin B 12 Deficiency | 1968 |
The biosynthesis of the methyl groups of choline in Ochromonas malhamensis.
Topics: Alkylation; Amino Alcohols; Choline; Eukaryota; Folic Acid; Homocysteine; In Vitro Techniques; Methionine; Microsomes; Mitochondria; Nucleosides; Phosphatidylcholines; Subcellular Fractions; Vitamin B 12 | 1966 |
Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Buffers; Carbon Isotopes; Centrifugation; Enzymes; Feedback; Folic Acid; Homocysteine; Liver; Methionine; Rats | 1967 |
Methotrexate hepatotoxicity.
Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides | 1984 |
Folate metabolism in cells from fragile X syndrome patients and carriers.
Topics: Adolescent; Adult; Aged; Cell Line; Child; Clone Cells; Culture Media; Drug Resistance; Female; Fibroblasts; Folic Acid; Fragile X Syndrome; Genetic Markers; Heterozygote; Homocysteine; Humans; Lymphocytes; Male; Methotrexate; Middle Aged; Sex Chromosome Aberrations | 1984 |
Folate metabolism in humans.
Topics: Amino Acids; Cells, Cultured; Chemical Phenomena; Chemistry; Culture Media; Folic Acid; Folic Acid Deficiency; Fragile X Syndrome; Histidine; Homocysteine; Humans; Intellectual Disability; Lymphocytes; Sex Chromosome Aberrations; Tetrahydrofolates | 1984 |
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Deoxyuracil Nucleotides; Female; Fluorodeoxyuridylate; Folic Acid; Homocysteine; Humans; Methyltransferases; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Rectal Neoplasms; Tetrahydrofolates; Thymidylate Synthase; Transplantation, Heterologous; Vitamin B 12 | 1982 |
Homocysteine in the plasma of renal transplant recipients: effects of cofactors for methionine metabolism.
Topics: Adult; Amino Acids; Dipeptides; Disulfides; Female; Folic Acid; Homocysteine; Humans; Kidney Transplantation; Male; Middle Aged; Pyridoxine; Vitamin B 12 | 1981 |
Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment.
Topics: Animals; Carbon Tetrachloride; Cystathionine; DNA; Folic Acid; Homocysteine; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1995 |
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida.
Topics: Adult; Female; Folic Acid; Gene Frequency; Homocysteine; Homozygote; Humans; Male; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Risk Factors; Spinal Dysraphism | 1995 |
Effective homocysteine metabolism may protect South African blacks against coronary heart disease.
Topics: Adult; Black People; Coronary Disease; Folic Acid; Homocysteine; Humans; Male; Methionine; South Africa; Vitamin B 12; Vitamins; White People | 1995 |
Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study.
Topics: Adult; Age Factors; Alcohol Drinking; Black People; Brain Ischemia; Cerebrovascular Disorders; Cohort Studies; Diabetes Mellitus; Educational Status; Epidemiologic Methods; Female; Folic Acid; Follow-Up Studies; Heart Diseases; Homocysteine; Humans; Hypertension; Male; Middle Aged; Proportional Hazards Models; Risk Factors; Sex Factors; Smoking; White People | 1995 |
Development of methionine synthase, cystathionine-beta-synthase and S-adenosyl-homocysteine hydrolase during gestation in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosylhomocysteinase; Animals; Cystathionine beta-Synthase; Decidua; Female; Folic Acid; Homocysteine; Hydrolases; Placenta; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar | 1995 |
Can lowering homocysteine levels reduce cardiovascular risk?
Topics: Aged; Cardiovascular Diseases; Carotid Stenosis; Folic Acid; Homocysteine; Humans; Male; Risk Factors; Vitamin B 12 | 1995 |
Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease.
Topics: Adult; Aged; Coronary Disease; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Regression Analysis; Risk Factors; Vitamin B 12 | 1995 |
Homocysteine metabolism in pregnancies complicated by neural-tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methylation; Methylmalonic Acid; Neural Tube Defects; Pregnancy; Vitamin B 12 | 1995 |
Short term betaine therapy fails to lower elevated fasting total plasma homocysteine concentrations in hemodialysis patients maintained on chronic folic acid supplementation.
Topics: Adult; Aged; Betaine; Fasting; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Renal Dialysis; Treatment Failure | 1995 |
Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate.
Topics: Adult; Chi-Square Distribution; Coronary Disease; Discriminant Analysis; Female; Folic Acid; France; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Pyridoxal Phosphate; Pyridoxine; Quebec; Regression Analysis; Risk Factors; Sex Factors; Vitamin B 12; Vitamin B Complex | 1995 |
Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients.
Topics: Aged; Analysis of Variance; Arteriosclerosis; Coronary Disease; Cystathionine; Folic Acid; Homocysteine; Humans; Hyperlipidemias; Methylmalonic Acid; Middle Aged; Pyridoxine; Risk Factors | 1995 |
Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis.
Topics: Aged; Aged, 80 and over; Carotid Stenosis; Confidence Intervals; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Odds Ratio; Pyridoxal Phosphate; Pyridoxine; Risk Factors; Ultrasonography; Vitamin B 12 | 1995 |
Plasma homocysteine in relation to serum cobalamin and blood folate in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Mental Disorders; Vitamin B 12; Vitamin B 12 Deficiency | 1994 |
Plasma levels of the atherogenic amino acid homocysteine in post-menopausal women with breast cancer treated with tamoxifen.
Topics: Aged; Arteriosclerosis; Breast Neoplasms; Cholesterol; Cysteine; Female; Folic Acid; Homocysteine; Humans; Menopause; Middle Aged; Tamoxifen; Time Factors; Vitamin B 12 | 1995 |
Increase in total plasma homocysteine concentration after cardiac transplantation.
Topics: Adolescent; Adult; Child; Female; Folic Acid; Glomerular Filtration Rate; Heart Transplantation; Hemoglobins; Homocysteine; Humans; Kidney; Male; Middle Aged; Time Factors; Vitamin B 12 | 1995 |
Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe.
Topics: Anemia, Megaloblastic; Anemia, Pernicious; Erythrocyte Indices; Female; Folic Acid; Folic Acid Deficiency; Gastrins; Hemoglobins; Homocysteine; Humans; Methylmalonic Acid; Nervous System Diseases; Neutrophils; Vitamin B 12 Deficiency; Zimbabwe | 1994 |
Effects of ageing on folate metabolism in rats fed a long-term folate deficient diet.
Topics: Aging; Animals; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1994 |
Homocysteine: relationship to serum cobalamin, serum folate, erythrocyte folate, and lobation of neutrophils.
Topics: Adult; Erythrocytes; Folic Acid; Homocysteine; Hospitalization; Humans; Middle Aged; Nervous System Diseases; Neutrophils; Reference Values; Vitamin B 12 | 1994 |
Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects.
Topics: Adult; Circadian Rhythm; Cysteine; Dietary Proteins; Dipeptides; Fasting; Female; Folic Acid; Food; Homocysteine; Humans; Kinetics; Male; Methionine | 1994 |
Withdrawal of folic acid supplementation in maintenance hemodialysis patients.
Topics: Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis; Renal Dialysis | 1994 |
Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver.
Topics: Animals; Body Weight; Choline; Diet; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Phosphorylcholine; Rats; Rats, Sprague-Dawley | 1994 |
Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Creatinine; Cysteine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Sex Factors; Vitamin B 12; Vitamins | 1994 |
Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.
Topics: Adult; Arteriosclerosis; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prevalence; Pyridoxine | 1994 |
Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?
Topics: Adult; Anencephaly; Cystathionine beta-Synthase; Encephalocele; Female; Folic Acid; Homocysteine; Humans; Meningomyelocele; Methionine; Neural Tube Defects; Pregnancy; Pregnancy Complications; Risk Factors | 1994 |
The methylfolate axis in neural tube defects: in vitro characterisation and clinical investigation.
Topics: Animals; Anticonvulsants; Female; Folic Acid; Homocysteine; Humans; In Vitro Techniques; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Rats; Rats, Wistar; Tetrahydrofolates | 1994 |
Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction.
Topics: Adult; Choline; Diet; Folic Acid; Folic Acid Deficiency; Glycine max; Homocysteine; Humans; Male; Methionine; Middle Aged; Nutritional Requirements; Nutritional Status; Vitamin B 12 | 1994 |
Development and reversion of methionine dependence in a human glioma cell line: relation to homocysteine remethylation and cobalamin status.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Brain Neoplasms; Female; Folic Acid; Glioblastoma; Homocysteine; Humans; Methionine; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1994 |
Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Female; Folic Acid; Homocysteine; Humans; Male; Microchemistry; Middle Aged; Reference Values; Sensitivity and Specificity; Sex Characteristics; Sulfhydryl Compounds; Vitamin B 12 | 1994 |
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population.
Topics: Aged; Aged, 80 and over; Aging; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Male; Nutritional Status; Pyridoxal Phosphate; Pyridoxine; Vitamin B 12; Vitamin B Complex | 1993 |
Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease.
Topics: Adult; Case-Control Studies; Coronary Disease; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Vitamin B 12 | 1994 |
Primary prevention of neural-tube defects with folic acid.
Topics: Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Nutritional Physiological Phenomena; Pregnancy; Primary Prevention | 1994 |
Study on the presence of homocysteine in ovarian follicular fluid.
Topics: Adult; Female; Folic Acid; Follicular Fluid; Homocysteine; Humans; Methionine; Pyridoxine; Reference Values; Vitamin B 12 | 1993 |
Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Cell Line; Enzyme Activation; Extracellular Space; Fetus; Fibroblasts; Folic Acid; Homocysteine; Humans; Infant; Lung; Male; Methionine; Methylation; Nitrous Oxide; S-Adenosylmethionine | 1993 |
Hyperhomocysteinemia in patients operated for lower extremity ischaemia below the age of 50--effect of smoking and extent of disease.
Topics: Adult; Arteriosclerosis; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Ischemia; Male; Methionine; Middle Aged; Postoperative Complications; Pyridoxine; Risk Factors; Smoking; Vitamin B 12 | 1993 |
[Homocystinuria: effectiveness of the treatment with pyridoxine, folic acid, and betaine].
Topics: Betaine; Child; Child, Preschool; Drug Evaluation; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Pyridoxine | 1993 |
Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats.
Topics: Animals; Choline; Choline Deficiency; DNA Modification Methylases; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Wistar | 1995 |
Plasma homocysteine and severity of atherosclerosis in young patients with lower-limb atherosclerotic disease.
Topics: Adult; Arteriosclerosis; Cerebrovascular Disorders; Coronary Disease; Fasting; Female; Folic Acid; Homocysteine; Humans; Leg; Male; Methionine; Middle Aged; Pyridoxine; Risk Factors; Vitamin B 12 | 1996 |
Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Folic Acid Deficiency; Half-Life; Hematinics; Homocysteine; Humans; Kinetics; Male; Methionine; Methylmalonic Acid; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1996 |
Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status.
Topics: Adult; Alcoholism; Blood Cell Count; Erythrocyte Indices; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Pyridoxine; Vitamin B 12 | 1996 |
Elevated plasma concentration of reduced homocysteine in patients with human immunodeficiency virus infection.
Topics: Adult; CD4 Lymphocyte Count; Cysteine; Dipeptides; Female; Folic Acid; HIV Antibodies; HIV Infections; HIV-1; Homocysteine; Humans; Interleukin-2; Lymphocytes; Male; Methionine; Middle Aged; Oxidation-Reduction; Oxidative Stress; Vitamin B 12 | 1996 |
Homocysteine: an independent risk factor associated with coronary disease and other arterial occlusive diseases in adults.
Topics: Adult; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors | 1995 |
Folic acid fortification of food.
Topics: Cardiovascular Diseases; Folic Acid; Food, Fortified; Homocysteine; Humans | 1996 |
Folic acid fortification of food.
Topics: Cardiovascular Diseases; Folic Acid; Food, Fortified; Homocysteine; Humans | 1996 |
Folic acid fortification of food.
Topics: Cardiovascular Diseases; Folic Acid; Food, Fortified; Homocysteine; Humans | 1996 |
Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Reference Values; Sex Characteristics; Vitamin B 12; Vitamins | 1996 |
Hyperhomocysteinemia in cyclosporine-treated renal transplant recipients.
Topics: Adult; Aged; Arteriosclerosis; Case-Control Studies; Cross-Sectional Studies; Cyclosporine; Erythrocytes; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Homocystinuria; Humans; Kidney Transplantation; Male; Middle Aged; Risk Factors | 1996 |
Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.
Topics: Case-Control Studies; Diet; Diet Surveys; Fasting; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Methionine; Methylation; Middle Aged; Myocardial Infarction; Odds Ratio; Pyridoxine; Risk Factors; Vitamin B 12 | 1996 |
Abnormal folate metabolism and neural tube defects.
Topics: Adult; Erythrocytes; Female; Folic Acid; Homocysteine; Homozygote; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors | 1996 |
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.
Topics: Adult; Aged; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic | 1996 |
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Administration, Oral; Analysis of Variance; Animal Feed; Animals; Apoptosis; Cell Division; Deoxyuracil Nucleotides; Ethanol; Folic Acid; Homocysteine; Liver; Male; Methionine; Proliferating Cell Nuclear Antigen; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Thymine Nucleotides | 1996 |
Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Framingham Study population.
Topics: Aged; Aged, 80 and over; Carotid Stenosis; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Male; Pyridoxine; Vitamin B 12 | 1996 |
Treatment of hyperhomocyst(e)inemia: physiological basis.
Topics: Betaine; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 1996 |
Folate and cardiovascular disease. Why we need a trial now.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Folic Acid; Homocysteine; Humans | 1996 |
Crohn's disease and vitamin B12 metabolism.
Topics: Adult; Crohn Disease; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Transcobalamins; Vitamin B 12 | 1996 |
The effect of folic acid on the homocysteine metabolism in human umbilical vein endothelial cells (HUVECs).
Topics: Cells, Cultured; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kinetics; Leucovorin; Tetrahydrofolates; Time Factors; Umbilical Veins | 1996 |
DNA hypomethylation in inflammatory arthritis: reversal with methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Vitamin B 12 | 1996 |
A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cohort Studies; Diet; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Pyridoxal Phosphate; Pyridoxine; Risk Factors | 1996 |
Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients.
Topics: Adult; Aged; Amino Acid Sequence; Cardiovascular Diseases; Cholesterol, HDL; Comorbidity; Creatinine; DNA Mutational Analysis; Female; Folic Acid; Glucose Intolerance; Homocysteine; Humans; Hypertension; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Peritoneal Dialysis; Polymorphism, Restriction Fragment Length; Prevalence; Renal Dialysis; Risk Factors; Smoking; Vitamin B 12 | 1996 |
Homocysteine: the new player in the field of coronary risk.
Topics: Coronary Disease; Folic Acid; Homocysteine; Humans; Risk Factors; Vitamin B Complex | 1996 |
Genes, greens, and homocysteine.
Topics: Angina Pectoris; Arteriosclerosis; Folic Acid; Homocysteine; Humans; Myocardial Infarction; Prospective Studies; Pyridoxine; Risk Factors; Vitamin B 12 | 1996 |
Hyperhomocysteinaemia and premature coronary artery disease in the Chinese.
Topics: Adult; Case-Control Studies; China; Cholesterol; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Hong Kong; Humans; Male; Middle Aged; Prevalence; Risk Factors; Smoking; Vitamin B 12 | 1996 |
Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Linear Models; Male; Methylmalonic Acid; Patient Selection; Prospective Studies; Vitamin B 12 Deficiency | 1996 |
Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits.
Topics: Adult; Female; Folic Acid; Health Status; Homocysteine; Humans; Male; Middle Aged; Pyridoxal Phosphate; Reference Values; Regression Analysis; Sex Characteristics; Vitamin B 12 | 1996 |
Determinants of hyperhomocysteinemia: a matter of nature and nurture.
Topics: Female; Folic Acid; Homocysteine; Humans; Male; Sex Characteristics; Vitamin B 12 | 1996 |
The effect of reduced glomerular filtration rate on plasma total homocysteine concentration.
Topics: Adult; Aged; Albuminuria; Alpha-Globulins; Creatinine; Erythrocytes; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Pyridoxal Phosphate; Regression Analysis; Renal Insufficiency | 1996 |
Cobalamin and folate deficiencies.
Topics: Biomarkers; Chemistry, Clinical; Folic Acid; Folic Acid Deficiency; Hematology; Homocysteine; Humans; Methylmalonic Acid; Practice Guidelines as Topic; Predictive Value of Tests; Sensitivity and Specificity; Vitamin B 12; Vitamin B 12 Deficiency | 1996 |
Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Colitis, Ulcerative; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hemolysis; Homocysteine; Humans; Male; Spondylitis, Ankylosing; Sulfasalazine | 1996 |
Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study.
Topics: Aged; Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Myocardial Infarction; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors | 1996 |
Are different reference intervals for methylmalonic acid and total homocysteine necessary in elderly people?
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Nutritional Status; Reference Values; Vitamin B 12 | 1996 |
Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.
Topics: Adult; Aged; Female; Folic Acid; Gene Frequency; Homocysteine; Homozygote; Humans; Male; Mass Screening; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Norway; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Vitamin B 12; Vitamin B 12 Deficiency | 1996 |
Hyperhomocysteinaemia--a common finding in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Dementia; Female; Folic Acid; Homocysteine; Humans; Male; Vascular Diseases; Vitamin B 12 | 1996 |
Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians.
Topics: Adult; Aged; Aged, 80 and over; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Oxidoreductases Acting on CH-NH Group Donors; Physicians; Polymorphism, Genetic; Risk Factors; United States | 1996 |
Homocysteine and cardiovascular disease.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Cardiovascular Diseases; Diet; Female; Folic Acid; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases; Risk Factors; Vitamin B Deficiency | 1996 |
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Neural Tube Defects; Oxidoreductases; Phenotype; Risk Factors; Vascular Diseases; Vitamin B 12 | 1996 |
Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations.
Topics: Aged; Aging; Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Odds Ratio; Osmolar Concentration; Peritoneal Dialysis, Continuous Ambulatory; Pyridoxine; Renal Dialysis; Risk Factors; Sex Distribution; Vitamin B 12 | 1996 |
[Hyperhomocysteinemia in coronary artery diseases. Apropos of a study on 102 patients].
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Coronary Disease; Female; Folic Acid; France; Hematinics; Homocysteine; Humans; Male; Middle Aged; Prevalence; Risk Factors; Severity of Illness Index | 1996 |
Decreased methylene tetrahydrofolate reductase activity due to the 677C-->T mutation in families with spina bifida offspring.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Child; Cysteine; Female; Folic Acid; Genetic Linkage; Genotype; Homocysteine; Homozygote; Humans; Lod Score; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Netherlands; Oxidoreductases; Point Mutation; Risk Factors; Spinal Dysraphism; Vitamin B 12 | 1996 |
Folic acid fortification of the food supply. Potential benefits and risks for the elderly population.
Topics: Aged; Aged, 80 and over; Anemia, Macrocytic; Cross-Sectional Studies; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Regression Analysis; Risk; Vitamin B 12; Vitamin B 12 Deficiency | 1996 |
[The prevalence of hyperhomocysteinemia in thromboangiitis obliterans. Does homocysteine play a role pathogenetically?].
Topics: Adult; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Prevalence; Pyridoxine; Risk Factors; Smoking; Statistics, Nonparametric; Thromboangiitis Obliterans; Time Factors; Vitamin B 12 | 1996 |
The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine.
Topics: Adolescent; Adult; Aged; Diet; Endotoxins; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Reference Values | 1996 |
Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid.
Topics: Animals; Chick Embryo; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic and Fetal Development; Folic Acid; Gastrula; Heart Defects, Congenital; Homocysteine; Mice; Neural Tube Defects; Teratogens | 1996 |
Methylenetetrahydrofolate reductase gene and coronary artery disease.
Topics: Adult; Case-Control Studies; Coronary Disease; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Random Allocation; Risk Factors | 1997 |
Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham Heart Study.
Topics: Aged; Aged, 80 and over; Cohort Studies; Diet; Diet Surveys; Female; Folic Acid; Homocysteine; Humans; Male; Massachusetts; Sex Factors | 1996 |
Homocysteine - a new arteriosclerotic risk factor in end-stage renal failure.
Topics: Arteriosclerosis; Cystathionine beta-Synthase; Folic Acid; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Risk Factors | 1997 |
Fasting and post-methionine homocyst(e)ine levels in a healthy Australian population.
Topics: Adult; Aged; Australia; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Reference Values; Vitamin B 12 | 1997 |
[Familial hyperhomocysteinemia with early development of atherosclerosis].
Topics: Adult; Aged; Arteriosclerosis; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Vitamin B 12 | 1996 |
Methylenetetrahydrofolate reductase thermolabile variant and human longevity.
Topics: Adult; Aged; Aged, 80 and over; Enzyme Stability; Female; Folic Acid; France; Genotype; Homocysteine; Hot Temperature; Humans; Longevity; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors | 1997 |
Homocysteine and coronary artery disease.
Topics: Adult; Coronary Disease; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Risk Factors | 1997 |
Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids.
Topics: Animals; Blood Coagulation; Blood Platelets; Chromatography, Liquid; Diet; Eicosanoids; Erythrocytes; Fatty Acids, Omega-3; Folic Acid; Folic Acid Deficiency; Glutathione; Homocysteine; Lipid Peroxidation; Macrophages, Peritoneal; Oxidative Stress; Phospholipids; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Thromboplastin; Thromboxanes | 1996 |
Correlation between plasma homocyst(e)ine and aortic atherosclerosis.
Topics: Aged; Aorta, Thoracic; Aortic Diseases; Arteriosclerosis; Echocardiography, Transesophageal; Female; Folic Acid; Homocysteine; Humans; Male; Multivariate Analysis; Observer Variation; Pyridoxal Phosphate; Pyridoxine; Risk Factors; Vitamin B 12 | 1997 |
Marginal folate deficiency as a possible cause of hyperhomocystinaemia in stroke patients.
Topics: Aged; Case-Control Studies; Cerebrovascular Disorders; Creatinine; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Time Factors; Vitamin B 12 | 1997 |
Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis.
Topics: Adult; Aging; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxal Phosphate; Risk Factors; Sex Characteristics; Vitamin B 12; Vitamin B Complex | 1997 |
Association between plasma homocysteine and extracranial carotid arterial disease in older persons.
Topics: Aged; Aged, 80 and over; Carotid Artery Diseases; Female; Folic Acid; Homocysteine; Humans; Male; Prospective Studies; Risk Factors; Vitamin B 12 | 1997 |
Atherogenesis and the homocysteine-folate-cobalamin triad: do we need standardized analyses?
Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Biomarkers; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Transcobalamins; Vitamin B 12 | 1997 |
Vitamin intake: a possible determinant of plasma homocyst(e)ine among middle-aged adults.
Topics: Analysis of Variance; Arteriosclerosis; Carotid Arteries; Case-Control Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nutrition Surveys; Pyridoxine; Regression Analysis; Sampling Studies; United States; Vitamin B 12 | 1997 |
Cyanocobalamin [c-lactam] inhibits vitamin B12 and causes cytotoxicity in HL60 cells: methionine protects cells completely.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Death; Enzyme Inhibitors; Folic Acid; HL-60 Cells; Homocysteine; Humans; Hydroxocobalamin; Methionine; Methylmalonyl-CoA Mutase; Propionates; Tetrahydrofolates; Vitamin B 12 | 1997 |
The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes.
Topics: Alleles; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Regression Analysis; Risk Factors; Vitamins | 1997 |
The thermolabile variant of 5,10-methylenetetrahydrofolate reductase is not associated with Parkinson's disease.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Parkinson Disease | 1997 |
[Deregulation of homocysteine metabolism and consequences for the vascular system].
Topics: Folic Acid; Homocysteine; Humans; Pyridoxine; Vascular Diseases; Vitamin B 12 Deficiency | 1997 |
Some vitamin sources relating to plasma homocysteine provide not only folate but also vitamins B-12 and B-6.
Topics: Aged; Diet; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Pyridoxine; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Elevated homocyst(e)ine levels with preeclampsia.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Parity; Pre-Eclampsia; Pregnancy; Risk Factors; Vascular Diseases; Vitamin B 12 | 1997 |
Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors | 1997 |
The 677C-->T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease.
Topics: Adult; Aged; Alcohol Drinking; Case-Control Studies; Comorbidity; Coronary Artery Disease; Disease Susceptibility; Erythrocytes; Fasting; Female; Folic Acid; Genes; Genotype; Homocysteine; Humans; Hyperlipidemias; Hypertension; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Obesity; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Risk Factors; Smoking | 1997 |
Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant; Male; Vitamin B 12 | 1997 |
Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kinetics; Male; Methionine; Middle Aged | 1997 |
Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.
Topics: Adult; Aged; Alleles; Cohort Studies; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Renal Dialysis; Renal Insufficiency; Vitamin B 12 | 1997 |
Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells.
Topics: Adult; Aged; Ascitic Fluid; Cysteine; Female; Folic Acid; Glycine; Homocysteine; Humans; Methionine; Methylation; Middle Aged; Ovarian Neoplasms; Vitamin B 12 | 1997 |
A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease.
Topics: Aged; Brain Ischemia; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osmolar Concentration; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Reference Values | 1997 |
Homocysteine in sickle cell disease: relationship to stroke.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Cerebrovascular Disorders; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Logistic Models; Male; Middle Aged; Odds Ratio; Severity of Illness Index | 1997 |
Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Anesthetics, Inhalation; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1997 |
Association between plasma total homocysteine and parental history of cardiovascular disease in children with familial hypercholesterolemia.
Topics: Adolescent; Age Distribution; Cardiovascular Diseases; Child; Diet; Family Health; Female; Folic Acid; Heterozygote; Homocysteine; Humans; Hyperlipoproteinemia Type II; Lipids; Male; Methylenetetrahydrofolate Reductase (NADPH2); Multivariate Analysis; Oxidoreductases Acting on CH-NH Group Donors; Parents; Point Mutation; Prevalence; Risk Factors; Sex Distribution; Vitamin B 12 | 1997 |
Altered folate and vitamin B12 metabolism in families with spina bifida offspring.
Topics: Adolescent; Adult; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk; Spinal Dysraphism; Statistics, Nonparametric; Vitamin B 12 | 1997 |
Vitamin B6 status, MTHFR and hyperhomocysteinaemia.
Topics: Adult; Alleles; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Pyridoxine; Vitamin B 12 | 1997 |
Plasma total homocysteine in a representative sample of 972 British men and women aged 65 and over.
Topics: Aged; alpha 1-Antichymotrypsin; Calcium; Creatinine; England; Female; Folic Acid; Homocysteine; Humans; Lutein; Male; Nutritional Status; Random Allocation; Reference Values; Regression Analysis; Risk Factors; Urea; Vascular Diseases; Vitamin B 12; Zinc | 1997 |
Excess prevalence of fasting and postmethionine-loading hyperhomocysteinemia in stable renal transplant recipients.
Topics: Adult; Aged; Arteriosclerosis; Fasting; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Methionine; Middle Aged; Pyridoxine | 1997 |
Homocysteine levels and cardiovascular disease.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Pyridoxine; Vitamin B 12; Vitamins | 1997 |
Elevated plasma levels of reduced homocysteine in common variable immunodeficiency--a marker of enhanced oxidative stress.
Topics: Adult; beta Carotene; Biomarkers; CD4 Lymphocyte Count; Common Variable Immunodeficiency; Cysteine; Dipeptides; Female; Folic Acid; Homocysteine; Humans; Lipid Peroxidation; Male; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; Sulfhydryl Compounds; Vitamin B 12; Vitamin E | 1997 |
Coronary artery disease associated with Helicobacter pylori infection is at least partially due to inadequate folate status.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Biological Availability; Coronary Disease; Folic Acid; Folic Acid Deficiency; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Intestinal Absorption; Models, Biological | 1997 |
Association between plasma homocysteine and coronary artery disease in older persons.
Topics: Age Factors; Aged; Aged, 80 and over; Coronary Disease; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Prevalence; Sex Factors; Vitamin B 12 | 1997 |
Low concentrations of folate in serum and erythrocytes of smokers: methionine loading decreases folate concentrations in serum of smokers and nonsmokers.
Topics: Adult; Cysteine; Dipeptides; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Smoking | 1997 |
[Cerebral vascular complication of hyperhomocysteinemia. Controlling thromboembolic complications with folates].
Topics: Adult; Factor V; Female; Folic Acid; Homocysteine; Homozygote; Humans; Intracranial Embolism and Thrombosis; Leg; Methylenetetrahydrofolate Dehydrogenase (NADP); Mutation; Thrombosis | 1997 |
[Megaloblastic anemia: rapid and economical study].
Topics: Adolescent; Adult; Algorithms; Anemia, Megaloblastic; Cost Control; Diagnosis, Differential; Diagnostic Tests, Routine; Female; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Histidine; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Predictive Value of Tests; Pregnancy; Pregnancy Complications, Hematologic; Reticulocyte Count; Retrospective Studies; Sensitivity and Specificity; Time Factors; Urinalysis; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Treatment with high-dose folic acid effectively lowers plasma homocysteine concentration in cyclosporine-treated renal transplant recipients.
Topics: Cyclosporine; Folic Acid; Homocysteine; Humans; Immunosuppressive Agents; Kidney Transplantation; Time Factors | 1997 |
The relationship between MTHFR genotype, serum homocysteine and folate levels.
Topics: Alleles; Analysis of Variance; Cerebrovascular Disorders; Deoxyribonucleases, Type II Site-Specific; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Restriction Mapping | 1997 |
Association between dietary fiber intake and the folate status of a group of female adolescents.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Diet Surveys; Diet, Vegetarian; Dietary Fiber; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Micronutrients; Nutritional Status; Radioimmunoassay; Regression Analysis | 1997 |
Vitamin B-12 and folic acid supplementation.
Topics: Aged; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study.
Topics: Adult; Aged; Arteriosclerosis; Blood Glucose; Cardiovascular Diseases; Cholesterol, HDL; Cohort Studies; Comorbidity; Diabetes Mellitus; Fasting; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis; Proportional Hazards Models; Prospective Studies; Pyridoxine; Renal Dialysis; Single-Blind Method; Smoking; Treatment Outcome; Vitamin B 12 | 1997 |
Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arteriosclerosis; Carotid Arteries; Carotid Stenosis; Cholesterol; Collagen; Diet, Atherogenic; Enzyme Activation; Folic Acid; Homocysteine; Homocystine; Hypercholesterolemia; Leg; Macaca fascicularis; Nitroprusside; Protein C; Pyridoxine; Thrombomodulin; Vasodilation; Vasomotor System; Vitamin B 12 | 1997 |
Plasma homocysteine levels and mortality in patients with coronary artery disease.
Topics: Coronary Disease; Folic Acid; Homocysteine; Humans; Risk Factors | 1997 |
Oral contraceptives did not affect biochemical folate indexes and homocysteine concentrations in adolescent females.
Topics: Adolescent; Adult; Alcohol Drinking; Contraceptives, Oral; Female; Folic Acid; Homocysteine; Humans; Life Style; Nutritional Status; Smoking; Surveys and Questionnaires; Vitamin B 12 | 1998 |
Plasma total homocysteine levels in hyperthyroid and hypothyroid patients.
Topics: Adult; Aged; Arteriosclerosis; Cardiovascular Diseases; Cholesterol; Creatinine; Female; Folic Acid; Homocysteine; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Multivariate Analysis; Risk Factors; Thyroxine; Triiodothyronine; Vitamin B 12 | 1998 |
Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia.
Topics: Aged; Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Vitamin B 12; Vitamins | 1998 |
A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages.
Topics: Abortion, Habitual; Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Osmolar Concentration; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Pregnancy Outcome; Pyridoxine; Reference Values; Retrospective Studies | 1998 |
Determinants of plasma homocysteine.
Topics: Coffee; Folic Acid; Homocysteine; Humans; Life Style; Smoking | 1998 |
Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study.
Topics: Adult; Aged; Aging; Coffee; Cohort Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Reference Values; Sex Factors; Smoking; Surveys and Questionnaires | 1998 |
Homocysteine, folate, vitamin B6, and cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Nutritional Status; Pyridoxine; Risk Factors | 1998 |
Cystathionine-beta-synthase deficiency: detection of heterozygotes by the ratios of homocysteine to cysteine and folate.
Topics: Adult; Aged; Cystathionine beta-Synthase; Cysteine; Female; Folic Acid; Genetic Carrier Screening; Homocysteine; Homocystinuria; Humans; Male; Middle Aged; Vitamin B 12 | 1998 |
Hyperhomocysteinaemia: a cardiovascular risk factor needing a large intervention trial?
Topics: Blood Coagulation Factors; Cardiovascular Diseases; Clinical Trials as Topic; Diet; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Pyridoxine; Risk Factors | 1997 |
Preventing coronary heart disease: B vitamins and homocysteine.
Topics: Cerebrovascular Disorders; Coronary Disease; Folic Acid; Homocysteine; Humans; Peripheral Vascular Diseases; Pyridoxine; Vitamins | 1998 |
Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group.
Topics: Adult; Analysis of Variance; Arteriosclerosis; Avitaminosis; Case-Control Studies; Cerebrovascular Disorders; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multicenter Studies as Topic; Peripheral Vascular Diseases; Pyridoxine; Risk Factors; Vascular Diseases; Vitamins | 1998 |
The relationship between maternal and neonatal umbilical cord plasma homocyst(e)ine suggests a potential role for maternal homocyst(e)ine in fetal metabolism.
Topics: Adult; Female; Fetal Blood; Folic Acid; Homocysteine; Homocystine; Humans; Infant, Newborn; Labor, Obstetric; Maternal-Fetal Exchange; Pregnancy; Reference Values; Umbilical Arteries; Umbilical Veins | 1998 |
High homocysteine, low folate, and low vitamin B6 concentrations: prevalent risk factors for vascular disease in heart transplant recipients.
Topics: Arteriosclerosis; Biomarkers; Coronary Thrombosis; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Heart Transplantation; Homocysteine; Humans; Male; Middle Aged; Morbidity; Postoperative Complications; Pyridoxine; Retrospective Studies; Risk Factors; Time Factors; Vitamin B 6 Deficiency | 1998 |
[Effects of folic acid supplementation on hyperhomocysteinemia in CAPD patients: effects on unsaturated fatty acids].
Topics: Administration, Oral; Adult; Aged; Fatty Acids, Unsaturated; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory | 1998 |
Eat right and take a multivitamin.
Topics: Cardiovascular Diseases; Congenital Abnormalities; Dietary Supplements; Edible Grain; Folic Acid; Food, Fortified; Homocysteine; Humans; Nutrition Policy; United States; Vitamins | 1998 |
Plasma total-homocysteine in anorexia nervosa.
Topics: Adolescent; Aging; Anorexia Nervosa; Child; Chromatography, High Pressure Liquid; Creatinine; Female; Folic Acid; Homocysteine; Humans; Reference Values; Vitamin B 12 | 1998 |
Variability and determinants of total homocysteine concentrations in plasma in an elderly population.
Topics: Aged; Aging; Blood Pressure; Cholesterol; Female; Folic Acid; Homocysteine; Humans; Male; Regression Analysis; Reproducibility of Results; Seasons; Sex Factors; Vitamin B 12 | 1998 |
Folic acid and Vitamin B6 supplementation and plasma homocysteine concentrations in healthy young women.
Topics: Adult; Arteriosclerosis; Drug Interactions; Fasting; Female; Folic Acid; Homocysteine; Humans; Pyridoxal Phosphate; Pyridoxine; Reference Values; Risk Factors | 1998 |
[Influence of levels of vitamin B2, B12, and folic acid on the values of basal homocysteinemia and after methionine overload].
Topics: Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Pyridoxine; Vitamin B 12 | 1998 |
Hyperhomocyst(e)inemia in renal transplant recipients with and without cyclosporine.
Topics: Arteriosclerosis; Case-Control Studies; Creatinine; Cyclosporine; Female; Folic Acid; Homocysteine; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Risk Factors; Vitamin B 12 | 1998 |
Strategies for the treatment of cystathionine beta-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years.
Topics: Adolescent; Adult; Betaine; Child; Child, Preschool; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Female; Folic Acid; Gastrointestinal Agents; Genetic Testing; Homocysteine; Homocystinuria; Humans; Infant; Infant, Newborn; Male; Pregnancy; Pregnancy Complications; Pyridoxine; Treatment Failure; Treatment Outcome | 1998 |
Association between plasma homocysteine and peripheral arterial disease in older persons.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Peripheral Vascular Diseases; Prevalence; Risk Factors; Vitamin B 12 | 1998 |
Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental intera
Topics: Adult; Alleles; Arteriosclerosis; Coronary Angiography; Female; Folic Acid; Genotype; Homocysteine; Humans; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Phenotype; Point Mutation; Polymorphism, Genetic | 1998 |
Major determinants of hyperhomocysteinemia in peritoneal dialysis patients.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osmolar Concentration; Oxidoreductases; Peritoneal Dialysis; Polymorphism, Genetic; Vitamin B 12 | 1998 |
Homocysteine and vascular disease.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Pyridoxine; Risk Factors; Vascular Diseases; Vitamin B 12 | 1998 |
Total serum homocysteine in senile dementia of Alzheimer type.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biological Transport, Active; Case-Control Studies; Cognition; Creatinine; Diet; Female; Folic Acid; Homocysteine; Humans; Learning; Male; Memory; Prospective Studies; Psychiatric Status Rating Scales; Reference Values; Regression Analysis; Statistics, Nonparametric; Vitamin B 12; Vitamin B 12 Deficiency | 1998 |
Schizophrenia and impaired homocysteine metabolism: a possible association.
Topics: Adult; Animals; Case-Control Studies; Comorbidity; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Pilot Projects; Schizophrenia | 1998 |
Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women.
Topics: Creatinine; Deoxyuracil Nucleotides; Diet; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Lymphocytes; Malondialdehyde; Middle Aged; Mitogens; Nutritional Requirements; Postmenopause; Thymine Nucleotides; Vitamin B 12 | 1998 |
[Plasma homocysteine levels in patients with ischemic cerebral infarction].
Topics: Brain Ischemia; Cerebral Infarction; Chromatography, High Pressure Liquid; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; Vitamin B 12 | 1998 |
Neural-tube defects are associated with low concentrations of cobalamin (vitamin B12) in amniotic fluid.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amniocentesis; Amniotic Fluid; Case-Control Studies; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Methionine; Methylation; Neural Tube Defects; Pilot Projects; Pregnancy; Reference Values; Vitamin B 12 | 1998 |
Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine.
Topics: Adult; Aged; Aged, 80 and over; Fasting; Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Pyridoxine; Reference Values | 1998 |
Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population.
Topics: Alleles; Case-Control Studies; Family; Female; Folic Acid; Genetic Linkage; Germany; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Spinal Dysraphism | 1998 |
Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages.
Topics: Abortion, Habitual; Adult; Dietary Supplements; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy | 1998 |
Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.
Topics: Arteriosclerosis; Cohort Studies; Coronary Disease; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Incidence; Male; Middle Aged; Polymorphism, Genetic; Prospective Studies; Pyridoxal Phosphate; Risk Factors; Vitamin B 12 | 1998 |
VPA-induced neural tube defects in mice. I. Altered metabolism of sulfur amino acids and glutathione.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Anticonvulsants; Female; Folic Acid; Glutathione; Homocysteine; Liver; Methionine; Mice; Neural Tube Defects; Pregnancy; Valproic Acid | 1998 |
Plasma homocyst(e)ine levels and folic acid supplementation.
Topics: Erythrocytes; Folic Acid; Homocysteine; Homocystine; Humans | 1998 |
Vitamin supplementation during weight reduction--favourable effect on homocysteine metabolism.
Topics: Adult; Diet, Reducing; Dietary Supplements; Energy Intake; Female; Folic Acid; Homocysteine; Humans; Male; Obesity; Pyridoxine; Statistics, Nonparametric; Vitamin B 12; Weight Loss | 1998 |
A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men.
Topics: Adult; Aged; Alleles; Case-Control Studies; Confidence Intervals; Coronary Disease; Diet; Folic Acid; Follow-Up Studies; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Riboflavin; Risk Factors; Smoking; United States; Vitamin B 12 | 1998 |
Growing support for vitamin supplements.
Topics: Dietary Supplements; Edible Grain; Folic Acid; Food, Fortified; Homocysteine; Humans | 1998 |
Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease.
Topics: Cerebrovascular Disorders; Folic Acid; Homocysteine; Humans; Hypertension; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors | 1998 |
A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity.
Topics: Adult; Black People; Child; Female; Folic Acid; Gene Frequency; Genetic Variation; Homocysteine; Homocystinuria; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Protein Denaturation; Spinal Dysraphism | 1998 |
Food-bound B12 absorption and serum total homocysteine in patients with low serum B12 levels.
Topics: Adult; Aged; Aged, 80 and over; Blood Cell Count; Female; Folic Acid; Food; Gastrins; Homocysteine; Humans; Intestinal Absorption; Male; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1998 |
Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels.
Topics: Aged; Aged, 80 and over; Diet; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Nutritional Status; Prospective Studies; Vitamin B 12 | 1998 |
Plasma homocysteine, vitamin B6, vitamin B12 and folic acid in end-stage renal disease during low-dose supplementation with folic acid.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Pyridoxine; Renal Dialysis; Vitamin B 12 | 1998 |
Homocysteine, B vitamins, and vascular-access thrombosis in patients treated with hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Arteriovenous Shunt, Surgical; Blood Vessel Prosthesis; Erythrocytes; Female; Folic Acid; Genotype; Graft Occlusion, Vascular; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Pyridoxine; Renal Dialysis; Risk Factors; Thrombophilia; Vitamin B 12 | 1998 |
Ability of endogenous folate from soy protein isolate to maintain plasma homocysteine and hepatic DNA methylation during methyl group depletion in rats.
Topics: 5-Methylcytosine; Animals; Caseins; Choline Deficiency; Cytosine; Dietary Proteins; DNA; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley; Soybean Proteins; Weaning | 1998 |
The diagnostic value of serum homocysteine concentration as a risk factor for coronary artery disease.
Topics: Coronary Disease; Demography; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Lipids; Lipoproteins; Male; Middle Aged; Odds Ratio; Retrospective Studies; Risk Factors; ROC Curve; Surveys and Questionnaires; Vitamin B 12 | 1998 |
[The recommended daily amount of folic acid is insufficient for optimum homocysteine levels].
Topics: Female; Folic Acid; Homocysteine; Humans; Nutritional Requirements | 1998 |
[The recommended daily intake of folic acid is insufficient for optimum homocysteine level].
Topics: Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia | 1998 |
Plasma homocysteine and folate are related to arterial blood pressure in type 2 diabetes mellitus.
Topics: Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged | 1998 |
Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps.
Topics: Adenoma; Biopsy; Colon; Colonic Polyps; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperplasia; Intestinal Mucosa; Male; Middle Aged; Nutritional Status | 1998 |
Venous thrombosis and hyperhomocysteinaemia.
Topics: Adult; Anticoagulants; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Recurrence; Risk Factors; Venous Thrombosis; Vitamin B 12 | 1998 |
Vitamins B6, B12, and folate: association with plasma total homocysteine and risk of coronary atherosclerosis.
Topics: Adult; Aged; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Regression Analysis; Risk Factors; Vitamin B 12 | 1998 |
Plasma homocysteine concentrations in patients with type 1 diabetes.
Topics: Adult; Cohort Studies; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Male; Microcirculation | 1998 |
Folic acid, riboflavin, thiamine, and vitamin B-6 status of a group of first-time blood donors.
Topics: Adolescent; Adult; Aged; Aspartate Aminotransferases; Australia; Blood Donors; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Pyridoxine; Reference Values; Riboflavin; Thiamine; Thiamine Deficiency | 1998 |
Kinetic model of folate metabolism in nonpregnant women consuming [2H2]folic acid: isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools.
Topics: Adult; Feces; Female; Folic Acid; Glutamates; Homocysteine; Humans; Kinetics; Metabolic Clearance Rate; Models, Biological; Nutritional Status | 1998 |
Urinary excretion of [2H4]folate by nonpregnant women following a single oral dose of [2H4]folic acid is a functional index of folate nutritional status.
Topics: Adult; Deuterium; Dietary Supplements; Erythrocytes; Female; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Kinetics; Nutritional Status | 1998 |
Nutrition and therapeutics.
Topics: Cardiovascular Diseases; Diet Therapy; Female; Folic Acid; Homocysteine; Humans; Male; Nutritional Status; Pyridoxine | 1998 |
[A correlation study on homocysteine metabolism in pregnant women and neural tube defects in urban and rural areas].
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Random Allocation; Rural Health; Urban Health; Vitamin B 12 | 1997 |
Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Case-Control Studies; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Male; Memory Disorders; Middle Aged; Polymorphism, Genetic; Predictive Value of Tests; Risk Factors; Vascular Diseases; Vitamin B 12 | 1998 |
Plasma homocysteine levels related to interactions between folate status and methylenetetrahydrofolate reductase: a study in 52 healthy subjects.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors | 1998 |
Folate supplementation in the dialysis patient--fragmentary evidence and tentative recommendations.
Topics: Arteriosclerosis; Dietary Supplements; Folic Acid; Hematopoiesis; Homocysteine; Humans; Renal Dialysis | 1998 |
[Serum homocysteine levels in healthy Chilean adults].
Topics: Adult; Aged; Chile; Diet; Energy Intake; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Postmenopause; Premenopause | 1998 |
Homocysteine and folate in healthy east London Bangladeshis.
Topics: Adult; Aged; Bangladesh; Case-Control Studies; Chromatography, High Pressure Liquid; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; London; Male; Middle Aged; White People | 1998 |
Absorption of dietary and supplemental folate in women with prior pregnancies with neural tube defects and controls.
Topics: Absorption; Adult; Biological Availability; Diet; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pteroylpolyglutamic Acids; Vitamin B 12; Zinc | 1998 |
Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation.
Topics: Adult; Endothelium, Vascular; Female; Fibronectins; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Pre-Eclampsia; Pregnancy; Risk Factors | 1998 |
The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis.
Topics: Adult; Age of Onset; Arteriosclerosis; DNA Mutational Analysis; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Risk Factors; Vitamin B 12 | 1998 |
Does the polymorphism 677C-T of the 5,10-methylenetetrahydrofolate reductase gene contribute to homocysteine-related vascular disease?
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adolescent; Adult; Aged; Aged, 80 and over; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases; Polymorphism, Genetic; Risk Factors; Vascular Diseases; Vitamin B 12 | 1998 |
Modulatory impact of cardiac rehabilitation on hyperhomocysteinemia in patients with coronary artery disease and "normal" lipid levels.
Topics: Aged; Coronary Disease; Exercise; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Treatment Outcome | 1998 |
Workshop on Folate, B12, and Choline. Sponsored by the Panel on Folate and other B vitamins of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Washington, D.C., March 3-4,
Topics: Biological Availability; Biomarkers; Cardiovascular Diseases; Choline; Congenital Abnormalities; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Male; Neoplasms; Neural Tube Defects; Nutrition Policy; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort Studies; Cost-Benefit Analysis; Family Practice; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methylmalonic Acid; Middle Aged; Practice Patterns, Physicians'; Reference Standards; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Occurrence of hyperhomocysteinemia 1 year after gastroplasty for severe obesity.
Topics: Adult; Blood Glucose; Cardiovascular Diseases; Cholesterol, HDL; Female; Folic Acid; Gastroplasty; Homocysteine; Humans; Insulin; Lipoprotein(a); Male; Nutritional Status; Obesity; Risk Factors; Triglycerides; Weight Loss | 1999 |
Homocysteine and cardiovascular disease.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans | 1998 |
Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects.
Topics: Adult; Black People; DNA; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Neural Tube Defects; Nutritional Status; Pregnancy; Pregnancy Complications; Rural Population; South Africa | 1999 |
Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Aging; Creatinine; Cysteine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Insulin; Middle Aged; Vitamin B 12 | 1999 |
Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients.
Topics: Adult; Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Homozygote; Humans; Kidney Transplantation; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors; Tissue Donors; Vitamin B 12 | 1999 |
Influence of haemodialysis on plasma total homocysteine concentration.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Male; Regression Analysis; Renal Dialysis; Serum Albumin; Urea | 1999 |
Hyperhomocyst(e)inaemia in children with chronic renal failure.
Topics: Adolescent; Child; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Homocystine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Postoperative Period; Severity of Illness Index | 1999 |
Response of hyperhomocysteinemia to folic acid supplementation in patients with end-stage renal disease.
Topics: Adult; Erythrocytes; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Middle Aged; Peritoneal Dialysis; Renal Dialysis | 1999 |
Increased plasma levels of homocysteine and other thiol compounds in rheumatoid arthritis women.
Topics: Adult; Amino Acids; Arthritis, Rheumatoid; Cysteine; Female; Folic Acid; Glutathione; Glycine; Homocysteine; Humans; Middle Aged; Vitamin B 12 | 1999 |
Changes in homocysteine levels during normal pregnancy.
Topics: Adult; Case-Control Studies; Cohort Studies; Confidence Intervals; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Pregnancy; Serum Albumin; Vitamin B 12 | 1999 |
Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation.
Topics: Analysis of Variance; Animals; Female; Folic Acid; Gestational Age; Homocysteine; Methionine; Methylation; Rats; Rats, Wistar; Valproic Acid | 1999 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epilepsy; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Pyridoxine; Risk Factors; Sex Factors; Valproic Acid; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1999 |
Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers.
Topics: Aged; Biomarkers, Tumor; Case-Control Studies; Folic Acid; Fruit; Homocysteine; Humans; Logistic Models; Male; Methylation; Middle Aged; Odds Ratio; Pancreatic Neoplasms; Pyridoxine; Risk; Smoking; Vegetables; Vitamin B 12 | 1999 |
A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Cohort Studies; Confidence Intervals; Female; Folic Acid; Homocysteine; Humans; Incidence; Maryland; Menopause; Middle Aged; Odds Ratio; Postmenopause; Prospective Studies; Pyridoxal Phosphate; Pyridoxine; Reproductive History; Risk Factors; Vitamin B 12 | 1999 |
[A young patient with chronic recurrent leg ulcers; hyperhomocysteinemia and heterozygote for factor V Leiden].
Topics: Adult; Anticoagulants; Bandages; Chronic Disease; Factor V; Folic Acid; Genetic Carrier Screening; Genetic Predisposition to Disease; Homocysteine; Humans; Leg Ulcer; Male; Metabolism, Inborn Errors; Secondary Prevention; Venous Thrombosis | 1998 |
Distribution of and factors associated with serum homocysteine levels in children: Child and Adolescent Trial for Cardiovascular Health.
Topics: Adolescent; Cardiovascular Diseases; Cross-Sectional Studies; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Male; Pyridoxine; Reference Values; Regression Analysis; Risk Factors; Vitamin B 12 | 1999 |
Prevalence and determinants of hyperhomocysteinemia in hemodialysis and peritoneal dialysis.
Topics: Creatinine; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Peritoneal Dialysis; Prevalence; Pyridoxine; Renal Dialysis; Smoking; Time Factors; Vitamin B 12 | 1999 |
Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control study.
Topics: Aged; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Multivariate Analysis; Risk Factors | 1999 |
Combination of low-dose folic acid and pyridoxine for treatment of hyperhomocysteinaemia in patients with premature arterial disease and their relatives.
Topics: Adult; Age of Onset; Arteriosclerosis; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Prospective Studies; Pyridoxine; Risk Factors | 1999 |
Methylene tetrahydrofolate reductase genotype and the risk and extent of coronary artery disease in a population with low plasma folate.
Topics: Case-Control Studies; Cholesterol; Coronary Disease; Folic Acid; Genotype; Homocysteine; Humans; Lipoproteins, HDL; Methylenetetrahydrofolate Dehydrogenase (NADP); Odds Ratio; Polymerase Chain Reaction; Regression Analysis; Risk; Turkey; Vitamin B 12 | 1999 |
Thermolabile methyltetrahydrofolate reductase associated with unusual venous and arterial thromboses.
Topics: Adult; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Thrombosis; Venous Thrombosis | 1999 |
Plasma homocysteine concentration in a Belgian school-age population.
Topics: Adolescent; Belgium; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Male; Puberty; Vitamin B 12 | 1999 |
Homocysteine and arteriosclerosis: subclinical and clinical disease associations.
Topics: Adolescent; Adult; Animals; Arteriosclerosis; Child; Child, Preschool; Comorbidity; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Middle Aged; Prevalence; Primates; Risk Factors; Swine; Swine, Miniature; Thrombophilia | 1999 |
Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
Topics: Adult; Aged; Amino Acid Substitution; Arteriosclerosis; Carotid Arteries; Carotid Stenosis; Comorbidity; Diet; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Health Surveys; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Obesity; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Pyridoxine; Risk Factors; Smoking; Tunica Intima; Ultrasonography; Vitamin B 12; Western Australia | 1999 |
The effect of folic acid fortification on plasma folate and total homocysteine concentrations.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cohort Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Vitamin B Complex | 1999 |
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prevalence; Risk; Vitamin B 12 | 1999 |
Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease.
Topics: Adult; Age Factors; Amino Acid Substitution; Arteriosclerosis; Body Mass Index; Comorbidity; Fasting; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Lipids; Male; Menopause; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pyridoxine; Smoking; Vitamin B 12 | 1999 |
Folate-homocysteine interrelations: potential new markers of folate status.
Topics: Adult; Dose-Response Relationship, Drug; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Models, Biological; Sensitivity and Specificity; Time Factors; Vitamin B 12 | 1999 |
Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and cardiovascular disease.
Topics: Administration, Oral; Adult; Aged; Albuminuria; Analysis of Variance; Blood Pressure; Cardiovascular Diseases; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Postmenopause; Premenopause; Pyridoxal Phosphate; Regression Analysis; Risk Factors; Vitamin B 12 | 1999 |
Supplementation with vitamin B12 decreases homocysteine and methylmalonic acid but also serum folate in patients with end-stage renal disease.
Topics: Adult; Aged; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Genotype; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Vitamin B 12 | 1999 |
[Obstetric problems followed by stroke].
Topics: Abortion, Habitual; Adult; Arteriosclerosis; Cerebral Infarction; Diagnosis, Differential; Female; Fetal Death; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Male; Methionine; Nutrition Disorders; Placental Insufficiency; Pregnancy; Pregnancy Complications, Cardiovascular; Pyridoxine; Smoking; Venous Thrombosis; Vitamin B 6 Deficiency | 1999 |
Folate and homocysteine metabolism in copper-deficient rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Copper; Erythrocytes; Folic Acid; Homocysteine; Liver; Male; Rats; Rats, Sprague-Dawley; Tetrahydrofolates; Vitamin B 12 | 1999 |
Effects of folic acid on homocysteine in persons classified by methylenetetrahydrofolate reductase genotype.
Topics: Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors | 1999 |
Genetic and nongenetic factors influencing plasma homocysteine levels in patients with ischemic cerebrovascular disease and in healthy control subjects.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Female; Folic Acid; Genotype; Homocysteine; Humans; Ischemic Attack, Transient; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Vitamin B 12 | 1999 |
Biological variability and reference intervals for total plasma homocysteine.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Reference Values; Sex Factors | 1999 |
Is pregnancy in diabetic women associated with folate deficiency?
Topics: Adult; Creatinine; Diet; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Glycated Hemoglobin; Homocysteine; Humans; Pregnancy; Pregnancy in Diabetics; Reference Values; Vitamin B 12 | 1999 |
Effect of usual doses of folate supplementation on elevated plasma homocyst(e)ine in hemodialysis patients: no difference between 1 and 5 mg daily.
Topics: Aged; Arteriosclerosis; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors | 1999 |
Higher total homocysteine concentrations and lower folate concentrations in premenopausal black women than in premenopausal white women.
Topics: Adolescent; Adult; Black People; Coronary Disease; Feeding Behavior; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Premenopause; Reference Values; Surveys and Questionnaires; Vitamin B 12; White People | 1999 |
Prevalence of mild fasting hyperhomocysteinemia in renal transplant versus coronary artery disease patients after fortification of cereal grain flour with folic acid.
Topics: Coronary Disease; Fasting; Female; Flour; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male; Middle Aged; Vitamin B 12 | 1999 |
Influence of 5,10-methylenetetrahydrofolate reductase gene polymorphism on plasma homocysteine concentration in patients with end-stage renal disease.
Topics: Cross-Sectional Studies; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Renal Dialysis; Vitamin B 12 | 1999 |
Determinants of fasting plasma total homocysteine levels among chronic stable renal transplant recipients.
Topics: Adult; Aged; Creatinine; Fasting; Female; Folic Acid; Homocysteine; Humans; Kidney Transplantation; Male; Middle Aged | 1999 |
Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications.
Topics: Adolescent; Adult; Age Factors; Aged; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Inflammatory Bowel Diseases; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Prospective Studies; Vitamin B 12 | 1999 |
Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature peripheral arterial occlusive disease. A prospective cohort study.
Topics: Adult; Age of Onset; Aged; Arterial Occlusive Diseases; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Pyridoxine; Risk; Risk Factors | 1999 |
[Nutritional status and energy expenditure in elders of differing socioeconomic level].
Topics: Absorptiometry, Photon; Aged; Anthropometry; Body Composition; Calorimetry; Energy Metabolism; Female; Folic Acid; Homocysteine; Humans; Male; Micronutrients; Nutritional Status; Socioeconomic Factors; Urban Population; Vitamin B 12 | 1999 |
Homocysteine, vitamins and sex.
Topics: Folic Acid; Homocysteine; Humans; Pyridoxine; Sex Factors; Vascular Diseases; Vitamin B 12 | 1999 |
Homocysteine, vitamin status and risk of vascular disease; effects of gender and menopausal status. European COMAC Group.
Topics: Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Menopause; Pyridoxine; Risk Factors; Sex Factors; Vascular Diseases; Vitamin B 12 | 1999 |
A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Cohort Studies; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Israel; Jews; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation | 1999 |
Cardiovascular morbidity and endothelial dysfunction in chronic haemodialysis patients: is homocyst(e)ine the missing link?
Topics: Aged; Biomarkers; Cardiovascular Diseases; Cohort Studies; Endothelium, Vascular; Female; Folic Acid; Hematinics; Hemostasis; Homocysteine; Homocystine; Humans; Male; Middle Aged; Morbidity; Nutritional Status; Renal Dialysis; Risk Factors; Time Factors | 1999 |
Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations.
Topics: Adolescent; Adult; Child; Cross-Sectional Studies; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Linear Models; Male; Middle Aged; Nutritional Status; Reference Values; United States; Vitamin B 12; Vitamin B Complex | 1999 |
Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; DNA Mutational Analysis; DNA, Complementary; Enzyme Activation; Ferredoxin-NADP Reductase; Folic Acid; Genes, Recessive; Genetic Complementation Test; Heteroduplex Analysis; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Mutation; Polymorphism, Single-Stranded Conformational; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing; Sequence Analysis, DNA; Vitamin B 12 | 1999 |
A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Canada; Case-Control Studies; Colorectal Neoplasms; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk Factors; Surveys and Questionnaires; United States; Vitamin B 12; White People | 1999 |
Folic acid fortification.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B Complex | 1999 |
Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome.
Topics: Down Syndrome; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Nutritional Physiological Phenomena; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy | 1999 |
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
Topics: Adult; Alcohol Drinking; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyribonucleases, Type II Site-Specific; Diet Surveys; Diet, Reducing; Dietary Supplements; DNA; Down Syndrome; Electrophoresis, Agar Gel; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Risk Factors; Surveys and Questionnaires | 1999 |
Within-person variation of plasma homocysteine and effects of posture and tourniquet application.
Topics: Adult; Blood Specimen Collection; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Posture; Risk Factors; Vascular Diseases | 1999 |
Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development.
Topics: Animals; Carrier Proteins; Cell Line; Embryonic and Fetal Development; Female; Fetal Death; Folate Receptor 1; Folate Receptors, GPI-Anchored; Folic Acid; Genotype; Homocysteine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nervous System; Pregnancy; Receptors, Cell Surface | 1999 |
Hyperhomocyst(e)inemia and the prevalence of atherosclerotic vascular disease in patients with end-stage renal disease.
Topics: Aged; Arteriosclerosis; Coronary Artery Disease; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Odds Ratio; Renal Dialysis; Retrospective Studies; Risk Factors; Sex Factors; Vitamin B 12 | 1999 |
Heart lines. Flexible arteries and folic acid.
Topics: Arteries; Elasticity; Folic Acid; Hematinics; Homocysteine; Humans; Hyperlipoproteinemia Type II | 1999 |
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia.
Topics: Adult; Case-Control Studies; Child, Preschool; Cleft Lip; Cleft Palate; Erythrocytes; Fasting; Female; Folic Acid; Homocysteine; Humans; Infant; Maternal-Fetal Exchange; Methionine; Pregnancy; Pyridoxine; Risk Factors; Vitamin B 12 | 1999 |
Epidemiologic correlates of serum folate and homocysteine levels among users and non-users of vitamin supplement.
Topics: Adult; Aged; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Nutritional Status; Prospective Studies; Vitamins | 1999 |
Influence of folic acid, pyridoxal phosphate and cobalamin on plasma homocyst(e)ine levels and the susceptibility of low-density lipoprotein to ex-vivo oxidation.
Topics: Adult; Aged; Arteriosclerosis; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Peripheral Vascular Diseases; Pyridoxal Phosphate; Risk Factors; Vitamin B 12 | 1999 |
Hyperhomocyst(e)inemia is associated with carotid atherosclerosis.
Topics: Age Factors; Body Mass Index; Carotid Artery Diseases; Carotid Artery, Common; Carotid Artery, Internal; Chromatography, High Pressure Liquid; Creatinine; Diabetes Complications; Female; Fluorescence; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypertension; Logistic Models; Male; Middle Aged; Regression Analysis; Risk Factors; Sex Factors; Smoking; Tunica Intima; Tunica Media; Ultrasonography; Vitamin B 12 | 1999 |
Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities.
Topics: Aged; Analysis of Variance; Ethnicity; Female; Folic Acid; Homocysteine; Humans; Los Angeles; Male; Methylmalonic Acid; Middle Aged; Racial Groups; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
Serum folate and homocysteine concentrations in large population samples of US ethnic and racial groups.
Topics: Adolescent; Aging; Child; Female; Folic Acid; Homocysteine; Humans; Male; Mexican Americans; Racial Groups; United States; White People | 1999 |
Extracellular magnesium regulates effects of vitamin B6, B12 and folate on homocysteinemia-induced depletion of intracellular free magnesium ions in canine cerebral vascular smooth muscle cells: possible relationship to [Ca2+]i, atherogenesis and stroke.
Topics: Animals; Arteriosclerosis; Basilar Artery; Calcium; Cells, Cultured; Cerebral Arteries; Dogs; Folic Acid; Homocysteine; Hyperhomocysteinemia; Magnesium; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Pyridoxine; Signal Transduction; Stroke; Vitamin B 12; Vitamins | 1999 |
Elevated homocysteine levels in patients with Raynaud's syndrome.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Raynaud Disease | 1999 |
The effect of diet on plasma homocysteine concentrations in healthy male subjects.
Topics: Adult; Cross-Sectional Studies; Diet; Diet, Vegetarian; Fasting; Folic Acid; Homocysteine; Humans; Male; Meat; Methionine; Methylation; Middle Aged; Vitamin B 12 | 1999 |
[Hyperhomocysteinemia is frequent in coronary disease patients. Study of 202 patients].
Topics: Aged; Case-Control Studies; Confidence Intervals; Coronary Disease; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Odds Ratio | 1999 |
[Gender differences in serum homocysteine levels and associated factors].
Topics: Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Sex Characteristics; Vitamin B 12 | 1999 |
Reversal of hyperhomocyst(e)inaemia in chronic renal failure-is folic or folinic acid the answer?
Topics: Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Leucovorin | 1999 |
Sustained reduction of hyperhomocysteinaemia with folic acid supplementation in predialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Pyridoxine; Renal Dialysis; Vitamin B 12 | 1999 |
Folic acid inhibits homocysteine-induced proliferation of human arterial smooth muscle cells.
Topics: Cell Division; Culture Techniques; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Microscopy, Fluorescence; Muscle, Smooth, Vascular | 1999 |
Folic acid and homocysteine in older women.
Topics: Aged; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cohort Studies; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Middle Aged; Prevalence; Pyridoxine | 1999 |
[Plasma homocysteine levels in patients with transient ischemic attacks].
Topics: Adult; Aged; Carotid Stenosis; Female; Folic Acid; Homocysteine; Humans; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Middle Aged; Prospective Studies; Risk Factors; Severity of Illness Index; Tomography, X-Ray Computed | 1999 |
Three months supplementation of hyperhomocysteinaemic patients with folic acid and vitamin B6 improves biological markers of endothelial dysfunction.
Topics: Adult; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Pyridoxine; Risk Factors; Thrombomodulin; Vascular Diseases; von Willebrand Factor | 1999 |
Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia.
Topics: Administration, Oral; Adult; Blood Flow Velocity; Drug Therapy, Combination; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxine; Treatment Outcome; Vasodilation; Vitamin B 12 | 1999 |
Can reduced folic acid and vitamin B12 levels cause deficient DNA methylation producing mutations which initiate atherosclerosis?
Topics: Arteriosclerosis; DNA Methylation; Folic Acid; Homocysteine; Humans; Models, Biological; Mutation; Vitamin B 12 | 1999 |
Concentrations of plasma methylmalonic acid in 80-year-olds show only weak relation to psychological performance.
Topics: Aged; Aged, 80 and over; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Methylmalonic Acid; Psychological Tests; Vitamin B 12 | 1999 |
The effect of estrogen replacement therapy on total plasma homocysteine in healthy postmenopausal women.
Topics: Adult; Estrogen Replacement Therapy; Folic Acid; Homocysteine; Humans; Linear Models; Lipids; Methionine; Middle Aged; Postmenopause; Pyridoxine; Reference Values; Time Factors; Vitamin B 12 | 2000 |
Coffee and homocysteine.
Topics: Coffee; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Randomized Controlled Trials as Topic; Vitamin B 12 | 2000 |
Homocysteine, B vitamins, and risk of cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Risk Factors; Vitamin B Complex | 2000 |
[Homocysteine as a risk factor for atherosclerosis].
Topics: Arteriosclerosis; Folic Acid; Homocysteine; Humans; Nutritional Physiological Phenomena; Risk Factors | 1997 |
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe.
Topics: Adolescent; Adult; Alleles; Black People; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Nutritional Physiological Phenomena; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Risk Factors; Vitamin B 12; Zimbabwe | 2000 |
Similarities in the epidemiology of neural tube defects and coronary heart disease: is homocysteine the missing link?
Topics: Coronary Disease; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Ireland; Male; Neural Tube Defects; Public Health; United Kingdom | 1999 |
Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infarctions: implications for therapy.
Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Folic Acid; Hematinics; Homocysteine; Humans; Infarction; Magnetic Resonance Imaging; Microvascular Angina; Muscular Diseases; Platelet Aggregation; Platelet Aggregation Inhibitors; Regional Blood Flow | 1999 |
Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men.
Topics: Case-Control Studies; Coronary Disease; Europe; Fasting; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Middle Aged; Risk Factors; United Kingdom; Vitamin B 12 | 2000 |
Low plasma folate in combination with the 677 C-->T methylenetetrahydrofolate reductase polymorphism is associated with increased risk of coronary artery disease in Koreans.
Topics: Adult; Aged; Asian People; Cardiac Catheterization; Coronary Disease; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Hyperhomocysteinemia; Korea; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors; Sex Factors; Vitamin B 12 | 2000 |
Association between total homocyst(e)ine and the likelihood for a history of acute myocardial infarction by race and ethnicity: Results from the Third National Health and Nutrition Examination Survey.
Topics: Age Distribution; Black People; Cholesterol; Comorbidity; Diabetes Mellitus; Educational Status; Female; Folic Acid; Homocysteine; Homocystine; Humans; Hypertension; Male; Mexico; Middle Aged; Multivariate Analysis; Myocardial Infarction; Nutrition Surveys; Odds Ratio; Prevalence; Risk Assessment; Sex Distribution; Smoking; United States; Vitamin B 12; White People | 2000 |
Folic acid and Down syndrome.
Topics: Dietary Supplements; Down Syndrome; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors | 2000 |
Plasma total homocysteine levels in subjects with hyperinsulinemia.
Topics: Adult; Aged; Blood Glucose; Coronary Disease; Cross-Sectional Studies; Female; Folic Acid; Glucose Tolerance Test; Homocysteine; Humans; Hyperhomocysteinemia; Hyperinsulinism; Insulin; Insulin Resistance; Life Style; Linear Models; Male; Middle Aged; Risk Factors | 2000 |
The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T).
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cerebrovascular Disorders; Erythrocyte Volume; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation | 2000 |
Effects of supplementation with folic acid and antioxidant vitamins on homocysteine levels and LDL oxidation in coronary patients.
Topics: Antioxidants; Ascorbic Acid; beta Carotene; Coronary Disease; Dietary Supplements; Folic Acid; Homocysteine; Humans; Lipid Peroxidation; Lipids; Lipoproteins, LDL; Vitamin B 12; Vitamin E; Vitamins | 2000 |
[Plasma homocysteine as a risk factor for apoplexy].
Topics: Folic Acid; Homocysteine; Humans; Risk Factors; Stroke | 2000 |
Homocysteine and folate levels as risk factors for recurrent early pregnancy loss.
Topics: Abortion, Habitual; Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Odds Ratio; Pregnancy; Risk | 2000 |
Treatment with different doses of folic acid in haemodialysis patients: effects on folate distribution and aminothiol concentrations.
Topics: Biomarkers; Cysteine; Dose-Response Relationship, Drug; Erythrocytes; Female; Folic Acid; Glutathione; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Pteroylpolyglutamic Acids; Renal Dialysis; Renal Insufficiency; Treatment Outcome | 2000 |
Plasma homocysteine levels in acute coronary syndromes.
Topics: Adult; Aged; Angina, Unstable; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Risk Factors; Vitamin B 12 | 1999 |
Hyperhomocysteinemia, MTHFR C677T genotype and low folate levels: a risk combination for acute coronary disease in a Portuguese population.
Topics: Adult; Case-Control Studies; Coronary Disease; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Portugal | 2000 |
Plasma homocysteine levels in renal transplanted patients on cyclosporine or tacrolimus therapy: effect of treatment with folic acid.
Topics: Analysis of Variance; Case-Control Studies; Cholesterol; Creatinine; Cyclosporine; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Kidney Transplantation; Linear Models; Male; Middle Aged; Multivariate Analysis; Risk Factors; Tacrolimus; Triglycerides; Vitamin B 12 | 2000 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2000 |
Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapy.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Anticonvulsants; Drug Stability; Female; Folic Acid; Genotype; Homocysteine; Hot Temperature; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osmolar Concentration; Oxidoreductases; Pyridoxine; Vitamin B 12 | 2000 |
Effect of chronic alcohol consumption on total plasma homocysteine level in rats.
Topics: Alcohol Drinking; Animals; Folic Acid; Hematinics; Homocysteine; Hyperhomocysteinemia; Male; Pyridoxine; Rats; Rats, Sprague-Dawley; Vitamin B 12 | 2000 |
High-normal serum homocysteine concentrations are associated with an increased risk of early atherosclerotic carotid artery wall lesions in healthy subjects.
Topics: Adult; Aged; Carotid Artery Diseases; Carotid Artery, Common; Female; Folic Acid; Homocysteine; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Osmolar Concentration; Reference Values; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography | 2000 |
The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Age of Onset; Aged; Amino Acid Substitution; Case-Control Studies; Fasting; Female; Folic Acid; Gene Frequency; Genetic Heterogeneity; Homocysteine; Humans; Hyperhomocysteinemia; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Risk Factors; Sex Factors; Tetrahydrofolates; Thrombophilia; Thrombosis; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
[Lowering high levels of fasting total homocysteine with folic acid and vitamins B in patients with venous thromboembolism: relationship between response and the C677T methylenetetrahydrofolate reductase (MTHRF) genotype].
Topics: Adult; Electrophoresis; Female; Folic Acid; Gene Expression; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Pyridoxine; Recurrence; Thrombophlebitis; Vitamin B 12 | 2000 |
Polymorphisms of genes controlling homocysteine/folate metabolism and cognitive function.
Topics: Adolescent; Alleles; Brain; Child; Cognition; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Intelligence; Intelligence Tests; Phenotype; Polymorphism, Genetic; Reference Values | 2000 |
Re: Pregnancy outcomes in celiac women.
Topics: Autoantibodies; Birth Weight; Celiac Disease; Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Muscle Fibers, Skeletal; Pregnancy; Pregnancy Complications; Risk Factors; Vitamin B 12 | 2000 |
Non-fasting reference intervals for the Abbott IMx homocysteine and AxSYM plasma folate assays: influence of the methylenetetrahydrofolate reductase 677 C-->T mutation on homocysteine.
Topics: Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Reference Values | 2000 |
Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography.
Topics: Aged; Case-Control Studies; Coronary Angiography; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Pyridoxine; Risk Factors; Vitamin B 12 | 2000 |
Leukoaraiosis at presentation and disease progression during follow-up in histologically confirmed cases of dementia.
Topics: Aged; Alzheimer Disease; Blood Pressure; Brain; Dementia, Vascular; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Male; Mental Status Schedule; Retrospective Studies; Tomography, X-Ray Computed | 2000 |
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; DNA Mutational Analysis; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Odds Ratio; Oxidoreductases; Placenta; Pregnancy; Vascular Diseases | 2000 |
Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Topics: Adult; Cardiovascular Diseases; Carotenoids; Cohort Studies; Coronary Disease; Finland; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lycopene; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Factors | 2000 |
Increasing plasma homocysteine during follow-up in heart transplant recipients: effects of folate and renal function.
Topics: Creatinine; Cyclosporine; Female; Folic Acid; Follow-Up Studies; Heart Transplantation; Homocysteine; Humans; Immunosuppressive Agents; Kidney; Male; Middle Aged; Prospective Studies | 2000 |
Low serum folate but normal homocysteine levels in patients with atherosclerotic vascular disease and matched healthy controls.
Topics: Aged; Arteriosclerosis; Cholesterol; Chromatography, High Pressure Liquid; Coronary Disease; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lipoproteins, HDL; Male; Middle Aged; Risk Factors; Triglycerides; Vitamin B 12; Vitamin E | 2000 |
Folate status worsens in recently institutionalized elderly people without evidence of functional deterioration.
Topics: Aged; Aged, 80 and over; Cognition; Diet Records; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Institutionalization; Male; Nutritional Status; Prospective Studies; Pyridoxine | 2000 |
Etiology and diagnostic evaluation of macrocytosis.
Topics: Adult; Aged; Alcohol Drinking; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Diseases; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; L-Lactate Dehydrogenase; Leukocyte Count; Liver Diseases; Liver Diseases, Alcoholic; Male; Methylmalonic Acid; Middle Aged; Platelet Count; Predictive Value of Tests; Prospective Studies; Reticulocyte Count; Sensitivity and Specificity; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Homocysteine and heart disease in Indian Asians.
Topics: Coronary Disease; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; India; Risk Factors; United Kingdom; Vitamin B 12 | 2000 |
Homocysteine and heart disease in Indian Asians.
Topics: Coronary Disease; Folic Acid; Folic Acid Deficiency; Fructose; Homocysteine; Humans; Hyperhomocysteinemia; India; Malabsorption Syndromes; United Kingdom; Vitamin B 12 | 2000 |
Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosis.
Topics: Arteriosclerosis; Cells, Cultured; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Infant, Newborn; Lipoproteins, HDL; Methionine; Proteins | 2000 |
Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon.
Topics: Adenomatous Polyposis Coli; Animals; Body Weight; Colon; Diet; DNA Damage; Exons; Folic Acid; Genes, p53; Genome; Hemoglobins; Homeostasis; Homocysteine; Intestinal Mucosa; Male; Mutation; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
Accurate and rapid "multiplex heteroduplexing" method for genotyping key enzymes involved in folate/homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Electrophoresis, Polyacrylamide Gel; Folic Acid; Genotype; Heteroduplex Analysis; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors | 2000 |
Plasma homocysteine and its determinants in diabetic retinopathy.
Topics: Biomarkers; Blood Pressure; Creatinine; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female; Folic Acid; Gene Frequency; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Vitamin B 12 | 2000 |
Impaired glucose tolerance (IGT) is not associated with disturbed homocysteine metabolism.
Topics: Blood Glucose; Cardiovascular Diseases; Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fasting; Folic Acid; Homocysteine; Humans; Insulin; Male; Methionine; Middle Aged; Proinsulin; Risk Factors; Time Factors; Vitamin B 12 | 2000 |
[TrioBe--the Medical Products Agency should re-evaluate the information text in the Fass!].
Topics: Catalogs, Drug as Topic; Drug Combinations; Drug Information Services; Folic Acid; Homocysteine; Humans; Pyridoxine; Risk Factors; Sweden; Vitamin B 12 | 2000 |
Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey.
Topics: Adolescent; Adult; Aged; Aging; Contraceptives, Oral, Hormonal; Creatinine; Estrogens; Female; Folic Acid; Health Surveys; Homocysteine; Hormone Replacement Therapy; Humans; Male; Middle Aged; United States; Vitamin B 12 | 2000 |
Case-control study of plasma folate, homocysteine, vitamin B(12), and cysteine as markers of cervical dysplasia.
Topics: Adult; Alcohol Drinking; Case-Control Studies; Contraceptives, Oral; Cysteine; DNA, Viral; Female; Folic Acid; Gravidity; Homocysteine; Humans; Middle Aged; Papillomaviridae; Papillomavirus Infections; Regression Analysis; Risk Factors; Tumor Virus Infections; Uterine Cervical Dysplasia; Vitamin B 12 | 2000 |
The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine.
Topics: Adult; Case-Control Studies; DNA Repair; Female; Folic Acid; Homocysteine; Humans; Odds Ratio; Risk Assessment; Uterine Cervical Neoplasms; Vitamin B 12 | 2000 |
Increased plasma homocysteine is an independent predictor of new coronary events in older persons.
Topics: Aged; Aged, 80 and over; Coronary Disease; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Recurrence; Risk Factors; Vitamin B 12 | 2000 |
Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Cysteine; Female; Folic Acid; Genotype; Homocysteine; Humans; Levodopa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Parkinson Disease; Point Mutation | 2000 |
Folate and vitamin B12 status of adolescent girls in northern Nigeria.
Topics: Adolescent; Biomarkers; Child; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Incidence; Nigeria; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Conversion of 5-formyltetrahydrofolic acid to 5-methyltetrahydrofolic acid is unimpaired in folate-adequate persons homozygous for the C677T mutation in the methylenetetrahydrofolate reductase gene.
Topics: Administration, Oral; Adult; Area Under Curve; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Tetrahydrofolates | 2000 |
Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis.
Topics: Betaine; Child, Preschool; Diagnosis, Differential; Fatal Outcome; Fibroblasts; Folic Acid; Hematinics; Homocysteine; Homocystinuria; Homozygote; Humans; Infant; Intellectual Disability; Lipotropic Agents; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Treatment Outcome | 2000 |
Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates.
Topics: Amino Acids; Breast Feeding; Cross-Sectional Studies; Cysteine; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Infant Food; Infant, Newborn; Male; Pyridoxine; Sulfur; Vitamin B 12 | 2000 |
The effect of different treatment regimens in reducing fasting and postmethionine-load homocysteine concentrations.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Pyridoxine; Risk Factors | 2000 |
Plasma homocysteine is a predictor of alcohol withdrawal seizures.
Topics: Adult; Ethanol; Female; Folic Acid; Forecasting; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Seizures; Substance Withdrawal Syndrome | 2000 |
Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents.
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Cholesterol; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Insulin; Lipoproteins; Male; Methylenetetrahydrofolate Reductase (NADPH2); Obesity; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Regression Analysis; Risk Factors; Triglycerides; Vitamin B 12 | 2000 |
Hyperhomocysteinemia in liver transplant recipients: prevalence and multivariate analysis of predisposing factors.
Topics: Creatinine; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Liver Transplantation; Male; Middle Aged; Multivariate Analysis; Postoperative Complications; Prevalence; Risk Factors; Treatment Outcome | 2000 |
A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia.
Topics: Base Sequence; Carrier Proteins; DNA Primers; Folic Acid; Heterozygote; Homocysteine; Homozygote; Humans; Membrane Proteins; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Reduced Folate Carrier Protein | 2000 |
Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Folic Acid; Food, Formulated; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Thrombomodulin; Vasodilator Agents | 2000 |
Folic acid, folate and homocysteine: human intervention studies.
Topics: Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2000 |
Effects of homocysteine on endothelial nitric oxide production.
Topics: Animals; Arginine; Bradykinin; Calcimycin; Cells, Cultured; Endothelium, Vascular; Folic Acid; Free Radical Scavengers; Homocysteine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Reactive Oxygen Species; Recombinant Proteins; Superoxides; Tyrosine | 2000 |
Effect of MTHFR 1298A-->C and MTHFR 677C-->T genotypes on total homocysteine, folate, and vitamin B(12) plasma concentrations in kdiney graft recipients.
Topics: Adult; Aged; Alleles; Base Sequence; Female; Folic Acid; Forecasting; Gene Frequency; Genotype; Homocysteine; Humans; Kidney Transplantation; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osmolar Concentration; Oxidoreductases Acting on CH-NH Group Donors; Vitamin B 12 | 2000 |
The (non-)sense of the methionine loading test for detecting hyperhomocysteinaemia.
Topics: Cardiovascular Diseases; Fasting; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine | 2000 |
A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease.
Topics: Age Factors; Base Sequence; Coronary Disease; Data Interpretation, Statistical; Female; Ferredoxin-NADP Reductase; Flavoproteins; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Molecular Sequence Data; Multivariate Analysis; Polymerase Chain Reaction; Polymorphism, Genetic; Regression Analysis; Risk; Sex Factors; Vitamin B 12 | 2000 |
The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients.
Topics: Aged; Albuminuria; Alleles; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors | 2000 |
Homocysteine elevation in sickle cell disease.
Topics: Adolescent; Adult; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Hemoglobin SC Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nutritional Requirements; Pilot Projects; Vitamin B 12 | 2000 |
The influence of age, sex, vitamin B(12), folate levels and methylenetetrahydrofolate reductase C677T genetic mutations on plasma homocysteine in the Chinese population.
Topics: Age Factors; Aged; China; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sex Factors; Thromboembolism; Vitamin B 12 | 2000 |
[Homocysteine and its metabolites in chronic renal insufficiency and the effect of a vitamin replacement].
Topics: Adult; Aged; Arteriosclerosis; Cysteine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Pyridoxine; Renal Dialysis; Severity of Illness Index; Vitamin B 12; Vitamin B Complex | 2000 |
Plasma and serum total homocysteine concentrations in paediatric patients, evaluated by high-performance liquid chromatography with fluorescence.
Topics: Child; Chromatography, High Pressure Liquid; Female; Fluorescence; Folic Acid; Homocysteine; Humans; Male; Reference Values; Vitamin B 12 | 2000 |
Age-related hearing impairment and B vitamin status.
Topics: Acoustic Impedance Tests; Age Factors; Aged; Aged, 80 and over; Aging; Audiometry, Pure-Tone; Audiometry, Speech; Female; Folic Acid; Homocysteine; Humans; Male; Presbycusis; Severity of Illness Index; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
The effect of C677T mutation of methylene tetrahydrofolate reductase gene and plasma folate level on hyperhomocysteinemia in patients with meningomyelocele.
Topics: Alleles; Asian People; Child; Female; Folic Acid; Gene Expression; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Meningomyelocele; Methylenetetrahydrofolate Dehydrogenase (NADP); Point Mutation; Polymerase Chain Reaction | 2000 |
Homocysteine levels in vegetarians versus omnivores.
Topics: Adult; Aged; Diet; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Slovakia; Surveys and Questionnaires; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women.
Topics: Adult; Aged; Aging; Blood Pressure; Body Mass Index; Coffee; Diet; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Life Style; Linear Models; Middle Aged; Reference Values; Smoking | 2000 |
Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduction in increased serum methylmalonic acid.
Topics: Adolescent; Aged; Aged, 80 and over; Female; Folic Acid; Gastroscopy; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Oxidation-Reduction; Regression Analysis; ROC Curve; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Oral folate reduces plasma homocyst(e)ine levels in hemodialysis patients with cardiovascular disease.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Dietary Supplements; Female; Folic Acid; Hematinics; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 2000 |
Folic acid and pyridoxal-5'-phosphate losses during high-efficiency hemodialysis in patients without hydrosoluble vitamin supplementation.
Topics: Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pyridoxal Phosphate; Renal Dialysis; Solubility; Vitamin B Complex | 2000 |
Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients.
Topics: Adult; Aged; Cardiovascular Diseases; Creatinine; Cross-Sectional Studies; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kidney Transplantation; Korea; Male; Middle Aged; Prevalence; Pyridoxal Phosphate; Serum Albumin; Vitamin B 12 | 2000 |
Nitric oxide in neonates.
Topics: Administration, Inhalation; Folic Acid; Homocysteine; Humans; Infant, Newborn; Lung Diseases, Obstructive; Nitric Oxide; Spinal Cord Diseases; Vitamin B 12 | 2000 |
Effect of heterozygosity for the methionine synthase 2756 A-->G mutation on the risk for recurrent cardiovascular events.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Disease-Free Survival; Erythrocytes; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Homocysteine; Humans; Incidence; Male; Middle Aged; Mutation; Myocardial Infarction; Polymorphism, Genetic; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Recurrence; Risk Factors | 2000 |
Water-soluble vitamin levels in patients undergoing high-flux hemodialysis and receiving long-term oral postdialysis vitamin supplementation.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Ascorbic Acid; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Oxalic Acid; Pyridoxine; Renal Dialysis; Riboflavin; Thiamine; Vitamins | 2000 |
Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors | 2000 |
Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.
Topics: Aged; Alleles; Alternative Splicing; Animals; Antigens, Surface; Carboxypeptidases; Cloning, Molecular; COS Cells; DNA Mutational Analysis; Folic Acid; Glutamate Carboxypeptidase II; Homocysteine; Humans; Hyperhomocysteinemia; Intestinal Absorption; Isoenzymes; Jejunum; Middle Aged; Molecular Sequence Data; Polymorphism, Genetic; RNA, Messenger; Sequence Analysis, DNA; Transfection; White People | 2000 |
Homocysteine concentration in primary and systemic sclerosis associated Raynaud's phenomenon.
Topics: Adult; Aged; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Osmolar Concentration; Oxidoreductases Acting on CH-NH Group Donors; Raynaud Disease; Scleroderma, Systemic; Vitamin B 12; von Willebrand Factor | 2000 |
Defining the steps of the folate one-carbon shuffle and homocysteine metabolism.
Topics: Folic Acid; Glycine; Homocysteine; Humans; Methionine; Methylation; Serine | 2000 |
Primed, constant infusion with [2H3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism.
Topics: Adult; Amino Acids; Cytosol; Folic Acid; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Male; Methionine; Methylation; Mitochondria; Nutritional Status; Pilot Projects; Serine | 2000 |
Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.
Topics: Animals; Azoxymethane; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Data Interpretation, Statistical; Disease Models, Animal; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Injections, Subcutaneous; Intestinal Mucosa; Liver; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Risk Factors; Time Factors | 2000 |
Urinary excretion of folate catabolites responds to changes in folate intake more slowly than plasma folate and homocysteine concentrations and lymphocyte DNA methylation in postmenopausal women.
Topics: DNA Methylation; Female; Folic Acid; Glutamates; Homocysteine; Humans; Middle Aged; Postmenopause | 2000 |
Vitamin B-12 deficiency and hyperhomocysteinemia are partly ameliorated by cobalt and nickel supplementation in pigs.
Topics: Animal Feed; Animals; Cobalt; Copper; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Iron; Liver; Male; Nickel; Swine; Trace Elements; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Serum total homocysteine concentration is related to self-reported heart attack or stroke history among men and women in the NHANES III.
Topics: Adult; Age Factors; Aged; Female; Folic Acid; Heart Arrest; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nutrition Surveys; Risk Factors; Self Disclosure; Sex Factors; Stroke; Vitamin B 12 | 2000 |
Risk factors for cardiovascular disease in renal transplant recipients: new insights.
Topics: Autoantibodies; Biomarkers; Cardiovascular Diseases; Female; Folic Acid; Glomerular Filtration Rate; Hemostasis; Homocysteine; Humans; Kidney Transplantation; Lipoprotein(a); Male; Middle Aged; Plasminogen Activator Inhibitor 1; Postoperative Complications; Reference Values; Risk Factors; Vitamin B 12 | 2000 |
Plasma homocysteine and severity of thoracic aortic atherosclerosis.
Topics: Adult; Aged; Aged, 80 and over; Aorta, Thoracic; Aortic Diseases; Arteriosclerosis; Biomarkers; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Echocardiography, Transesophageal; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Risk Factors; Vitamin B 12 | 2000 |
Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects.
Topics: Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Cognition; Dementia; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Risk Factors; Vitamin B 12 | 2000 |
Hyperhomocysteinemia in renal transplant recipients with cyclosporine.
Topics: Cyclosporine; Erythrocytes; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Reference Values; Vitamin B 12 | 2000 |
Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects.
Topics: Adult; Aged; Cystathionine; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Kidney; Male; Methylmalonic Acid; Middle Aged; Models, Chemical; Pyridoxine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2000 |
Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance.
Topics: Aged; Cohort Studies; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Female; Folic Acid; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Logistic Models; Male; Metabolic Clearance Rate; Metformin; Middle Aged; Vitamin B 12 | 2000 |
Hyperhomocysteinemia in renal transplantation: preliminary results.
Topics: Adult; Aged; Cross-Sectional Studies; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prevalence; Pyridoxine; Time Factors; Vitamin B 12 | 2000 |
Changes of fasting plasma total homocysteine in the early phase of renal transplantation.
Topics: Adult; Biomarkers; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Kidney Transplantation; Male; Middle Aged; Postoperative Period; Reference Values; Time Factors; Treatment Outcome | 2000 |
Long-term reduction of plasma homocysteine levels by super-flux dialyzers in hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxine; Renal Dialysis; Serum Albumin; Time Factors; Vitamin B 12 | 2001 |
Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.
Topics: Administration, Oral; Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Diseases; Cystine; Diet; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Male; Methionine; Rats; Rats, Sprague-Dawley; Tunica Intima; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Effect of total plasma homocysteine on cervical dysplasia risk.
Topics: Adult; Biomarkers; Case-Control Studies; Contraceptives, Oral; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Papillomaviridae; Papillomavirus Infections; Parity; Risk Factors; Smoking; Tumor Virus Infections; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2000 |
Homocysteine-lowering effect of 500 microg folic acid every other day versus 250 microg/day.
Topics: Adolescent; Adult; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Time Factors | 2000 |
Increased levels of homocysteine in patients with Crohn's disease are related to folate levels.
Topics: Adult; Aged; Anti-Inflammatory Agents; Budesonide; Case-Control Studies; Crohn Disease; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Prednisone; Risk Factors; Thromboembolism; Time Factors; Vitamin B 12 | 2000 |
Prevention of vitamin B-12 deficiency in old age.
Topics: Aged; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Food, Fortified; Homocysteine; Humans; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore.
Topics: Aged; Aging; Asian People; Cohort Studies; Exercise; Female; Folic Acid; Genotype; Homocysteine; Humans; Interviews as Topic; Life Style; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Prospective Studies; Pyridoxine; Risk Factors; Sex Factors; Singapore; Smoking; Vascular Diseases; Vitamin B 12 | 2001 |
Targeted disruption of the methionine synthase gene in mice.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Base Sequence; Cardiovascular Diseases; DNA Primers; Embryonic and Fetal Development; Female; Folic Acid; Gene Targeting; Heterozygote; Homocysteine; Homozygote; Humans; Methionine; Mice; Mice, Knockout; Neural Tube Defects; Pregnancy; Risk Factors; Vitamin B 12 Deficiency | 2001 |
Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood.
Topics: Adult; Aged; Amino Acid Substitution; Caco-2 Cells; Codon; DNA, Complementary; Female; Folic Acid; France; Gene Expression Regulation, Neoplastic; Gene Frequency; Genotype; Homocysteine; HT29 Cells; Humans; Male; Middle Aged; Neoplasm Proteins; Phenotype; Polymorphism, Genetic; Transcobalamins; Transcription, Genetic; Transfection; Vitamin B 12; White People | 2001 |
Methylenetetrahydrofolate reductase genotypes and predisposition to atherothrombotic disease; evidence that all three MTHFR C677T genotypes confer different levels of risk.
Topics: Coronary Artery Disease; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors | 2001 |
Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; Cross-Sectional Studies; Dementia; Dementia, Vascular; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Male; Pyridoxine; Reference Values; Vitamin B 12 | 2000 |
Is there a role of cyclosporine A on total homocysteine export from human renal proximal tubular epithelial cells?
Topics: Biological Transport, Active; Cells, Cultured; Cyclosporine; Epithelial Cells; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Kidney Transplantation; Kidney Tubules, Proximal; Methionine; Pyridoxine; Vitamin B 12 | 2001 |
Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers.
Topics: Adult; Diet; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Semen; Smoking; Sperm Count; Spermatozoa; Tetrahydrofolates; Vitamin B 12; Vitamins | 2001 |
5,10-methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) cohort.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Cohort Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Oxidoreductases; Polymorphism, Genetic; Sex Factors | 2000 |
Relationships between homocysteine, folate and vitamin B12 levels with the methylenetetrahydrofolate reductase polymorphism, in Indians from Western Venezuela.
Topics: Analysis of Variance; Folic Acid; Genotype; Homocysteine; Humans; Indians, South American; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Venezuela; Vitamin B 12; Vitamin B Complex | 2001 |
Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Cystathionine beta-Synthase; Environmental Exposure; Environmental Pollution; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prospective Studies; Smoking; Vitamin B 12 | 2001 |
Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Biomarkers; Cardiovascular Diseases; Creatinine; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperthyroidism; Hypothyroidism; Linear Models; Male; Metabolic Clearance Rate; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Polymorphism, Genetic; Prospective Studies; Risk Factors; Sex Factors; Smoking; Thyroid Function Tests; Thyroxine; Vitamin B 12 | 2001 |
Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers.
Topics: Animals; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Homocysteine; Hyperhomocysteinemia; Lipid Peroxides; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2001 |
Effects of methionine loading on plasma and erythrocyte sulphur amino acids and sulph-hydryls before and after co-factor supplementation in haemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Sulfur; Case-Control Studies; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxine; Renal Dialysis; Sulfhydryl Compounds | 2001 |
Homocysteine and human reproduction.
Topics: Culture Techniques; Female; Folic Acid; History, 17th Century; History, 20th Century; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Reproduction | 2000 |
Homocysteinaemia during pregnancy and placental disease.
Topics: Adult; Female; Fetal Death; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Humans; Placenta; Placenta Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome | 2000 |
Traditional and alternative nutrition--levels of homocysteine and lipid parameters in adults.
Topics: Adult; Aged; Arteriosclerosis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dairy Products; Diet, Vegetarian; Eggs; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Methionine; Middle Aged; Nutritional Physiological Phenomena; Reference Values; Risk Factors; Vitamin B 12 | 2000 |
Plasma folate, vitamin B(12), and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Logistic Models; Odds Ratio; Peru; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Surveys and Questionnaires; Vitamin B 12 | 2001 |
Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia.
Topics: Birth Weight; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Primers; Electrophoresis, Polyacrylamide Gel; Female; Folic Acid; Genotype; Gestational Age; HELLP Syndrome; Homocysteine; Humans; Infant, Newborn; Linear Models; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Pre-Eclampsia; Pregnancy; Radioimmunoassay; Regression Analysis; Vitamin B 12 | 2001 |
Unsuspected hyperhomocysteinemia in chronically anticoagulated patients.
Topics: Aged; Anticoagulants; Case-Control Studies; Chronic Disease; Diet; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Vegetables; Vitamin K | 2001 |
Population determinants of homocysteine.
Topics: Adult; Aged; Aged, 80 and over; Coffee; Cohort Studies; Diet Surveys; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Riboflavin; Risk Factors; Smoking | 2001 |
Lifestyle effects on homocysteine and an alcohol paradox.
Topics: Aged; Aging; Alcohol Drinking; Animals; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male | 2001 |
Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Caffeine; Cohort Studies; Creatinine; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Hypertension; Kidney; Male; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Pyridoxine; Riboflavin; Sex Factors; Smoking; Vitamin B 12 | 2001 |
Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Coffee; Cross-Sectional Studies; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Life Style; Linear Models; Male; Methylmalonic Acid; Risk Factors; Smoking; Tea; Vascular Diseases; Vitamin B 12 | 2001 |
Difference in the homocysteine-lowering effect of folic acid in haemodialysis patients with and without occlusive vascular disease.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Renal Dialysis; Vascular Diseases | 2001 |
Mild hyperhomocyst(e)inemia: a possible risk factor for cervical artery dissection.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiography; Carotid Artery, Internal, Dissection; Comorbidity; Disease Susceptibility; Female; Folic Acid; Genotype; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Vertebral Artery Dissection; Vitamin B 12 | 2001 |
[Plasma homocysteine levels in hyperinsulinemic patients].
Topics: Adult; Blood Glucose; Cohort Studies; Female; Folic Acid; Glucose Tolerance Test; Homocysteine; Humans; Hyperinsulinism; Male; Middle Aged; Severity of Illness Index; Sex Factors; Vitamin B 12 | 2001 |
Does disturbed homocysteine and folate metabolism in depression result from enhanced oxidative stress?
Topics: Depressive Disorder; Folic Acid; Homocysteine; Humans; Oxidative Stress | 2001 |
Effect of diet and 677 C-->T 5, 10-methylenetetrahydrofolate reductase genotypes on plasma homocyst(e)ine concentrations in slovak adolescent population.
Topics: Adolescent; Cardiovascular Diseases; Child; Cholesterol, Dietary; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy Intake; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mutation; Pyridoxine; Risk Factors; Slovakia; Surveys and Questionnaires | 2000 |
The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study.
Topics: Aged; Aging; Alleles; Demography; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Regression Analysis; Sex Characteristics; Vitamin B 12 | 2001 |
Hyperhomocysteinemia in Greek patients with inflammatory bowel disease.
Topics: Adult; Aged; Colitis, Ulcerative; Crohn Disease; Female; Folic Acid; Greece; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Thrombosis | 2000 |
Nutrition and metabolism.
Topics: Folic Acid; Homocysteine; Humans; Metabolism; Nutritional Physiological Phenomena | 2001 |
[Folic acid levels, homocysteine and polymorphism of methylenetetrahydrofolate reductase enzyme (MTHFR) in patients with pre-eclampsia and eclampsia].
Topics: Adult; Case-Control Studies; Eclampsia; Female; Folic Acid; Genotype; Homocysteine; Humans; Longitudinal Studies; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Prospective Studies | 2001 |
Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxine; Valproic Acid | 2000 |
Racial variation in fasting and random homocysteine levels.
Topics: Black People; Blood Urea Nitrogen; Body Mass Index; Creatinine; Fasting; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Male; New York City; Personnel, Hospital; Random Allocation; Reference Values; Time Factors; Vitamin B 12; White People | 2001 |
Hemostatic alterations in patients with acute, unilateral vestibular paresis.
Topics: Acute Disease; Adult; Aged; Antibodies, Anticardiolipin; Apolipoproteins; Cholesterol; Female; Fibrin Fibrinogen Degradation Products; Folic Acid; Follow-Up Studies; Hemostasis; Homocysteine; Humans; Immunoglobulin G; Immunoglobulin M; Male; Meniere Disease; Middle Aged; Paresis; Prevalence; Prothrombin Time; Severity of Illness Index; Triglycerides; Vertebrobasilar Insufficiency; Vestibule, Labyrinth | 2001 |
Homocysteine, folate, vitamin B12, and transcobalamins in patients undergoing successive hypo- and hyperthyroid states.
Topics: Folic Acid; Homocysteine; Humans; Hyperthyroidism; Hypothyroidism; Transcobalamins; Vitamin B 12 | 2001 |
Homocysteine, folate, and dysplasia: who is the enemy?
Topics: Contraceptives, Oral; Copper; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Risk Factors; Uterine Cervical Dysplasia | 2001 |
Plasma homocysteine and microvascular complications in type 1 diabetes.
Topics: Adult; Albuminuria; Case-Control Studies; Creatinine; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Vitamin B 12 | 2000 |
Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction.
Topics: Adult; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Myocardial Infarction; Polymorphism, Genetic; Risk Factors; Turkey | 2001 |
Association between plasma folate and coronary disease independent of homocysteine.
Topics: Case-Control Studies; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Risk Factors | 2001 |
Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population.
Topics: Alleles; Case-Control Studies; Cystathionine beta-Synthase; Female; Folic Acid; Gene Frequency; Genotype; Germany; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors | 2001 |
Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Blood Pressure; Creatinine; Cystatin C; Cystatins; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pyridoxine; Vitamin B 12 | 2001 |
Folate, homocysteine and methionine loading in patients on carbamazepine.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged | 2001 |
High cysteine levels in renal transplant recipients: relationship with hyperhomocysteinemia and 5,10-MTHFR polymorphism.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Cysteine; Female; Folic Acid; Genotype; Homocysteine; Humans; Kidney Transplantation; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases; Plasminogen Activator Inhibitor 1; Point Mutation; Polymorphism, Genetic; Pyridoxine; Vitamin B 12 | 2001 |
[Influence of menopausal status in homocysteine plasma levels].
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Lipoproteins; Male; Middle Aged; Postmenopause; Premenopause; Spain | 2001 |
Homocysteine, vitamin B12, serum and erythrocyte folate in peritoneal dialysis patients.
Topics: Aged; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peritoneal Dialysis; Vitamin B 12 | 2001 |
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
Topics: Adolescent; Adult; Age of Onset; Alleles; Case-Control Studies; Coronary Disease; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prevalence; Risk Factors | 2001 |
Influence of folic acid-fortified foods on folate status in a folate depletion-repletion rat model.
Topics: 3T3 Cells; Animals; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Kidney; Liver; Male; Mice; Rats; Rats, Wistar | 2001 |
Renal insufficiency, vitamin B(12) status, and population attributable risk for mild hyperhomocysteinemia among coronary artery disease patients in the era of folic acid-fortified cereal grain flour.
Topics: Adult; Aged; Coronary Artery Disease; Coronary Disease; Creatinine; Edible Grain; Female; Flour; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Renal Insufficiency; Risk Factors; Vitamin B 12 | 2001 |
Folate status in women of childbearing age residing in Southern California after folic acid fortification.
Topics: Adolescent; Adult; California; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Food, Fortified; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Nutritional Requirements; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors; Social Class | 2001 |
Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes--a population-based study.
Topics: Age Factors; Aged; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Population Surveillance; Sex Factors; Sweden; Vitamin B 12; Vitamins | 2001 |
Influence of vitamin-optimized plasma homocysteine cutoff values on the prevalence of hyperhomocysteinemia in healthy adults.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prevalence; Pyridoxine; Vitamin B 12; Vitamins | 2001 |
Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Betaine; Betaine-Homocysteine S-Methyltransferase; Creatinine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methyltransferases; Middle Aged; Peritoneal Dialysis; Predictive Value of Tests; Pyridoxine; Renal Dialysis; Sarcosine; Uremia; Vitamin B 12; Zinc | 2001 |
Plasma proteins containing damaged L-isoaspartyl residues are increased in uremia: implications for mechanism.
Topics: Aspartic Acid; Biomarkers; Blood Proteins; Chromatography, High Pressure Liquid; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Methylation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Renal Dialysis; S-Adenosylhomocysteine; Serum Albumin; Uremia | 2001 |
Association between B vitamin intake and plasma homocysteine concentration in the general Dutch population aged 20-65 y.
Topics: Adult; Aged; Alcohol Drinking; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Netherlands; Smoking; Vitamin B Complex | 2001 |
Plasma total cysteine as a risk factor for vascular disease: The European Concerted Action Project.
Topics: Adult; Case-Control Studies; Creatinine; Cysteine; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Pyridoxine; Risk Factors; Vascular Diseases; Vitamin B 12 | 2001 |
Reduced total plasma homocyst(e)ine in children and adolescents with type 1 diabetes.
Topics: Adolescent; Child; Creatinine; Diabetes Mellitus, Type 1; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Homocystine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Vitamin B 12 | 2001 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
Factors explaining the difference of total homocysteine between men and women in the European Investigation Into Cancer and Nutrition Potsdam study.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Body Mass Index; Cohort Studies; Female; Folic Acid; Germany; Gonadal Steroid Hormones; Homocysteine; Humans; Linear Models; Male; Middle Aged; Neoplasms; Nutritional Physiological Phenomena; Sex Factors; Vitamin B 12 | 2001 |
Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: correlations with diet.
Topics: Body Mass Index; Diet; Dietary Fats; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Neoplasms; Pyridoxine; Reference Values; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2001 |
Colonic mucosal concentrations of folate are accurately predicted by blood measurements of folate status among individuals ingesting physiologic quantities of folate.
Topics: Adenoma; Adult; Colonic Neoplasms; Diet; Dietary Supplements; Female; Folic Acid; Hematinics; Homocysteine; Humans; Intestinal Mucosa; Male; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels.
Topics: Aged; Aged, 80 and over; C-Reactive Protein; Cohort Studies; Creatinine; Diet; Female; Folic Acid; Homocysteine; Humans; Inflammation; Logistic Models; Male; Massachusetts; Pyridoxal Phosphate; Pyridoxine; Risk Factors; Serum Albumin; Vitamin B 12 | 2001 |
Elevated homocysteine levels with weight loss after Lap-Band surgery: higher folate and vitamin B12 levels required to maintain homocysteine level.
Topics: Adult; Case-Control Studies; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Obesity, Morbid; Vitamin B 12; Weight Loss | 2001 |
Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification.
Topics: Aged; Aged, 80 and over; Carotid Stenosis; Cohort Studies; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Male; Odds Ratio; Risk; United States; Vitamin B Complex | 2000 |
Effect of feeding on circulating micronutrient concentrations in the Burmese python (Python molurus).
Topics: Animals; Blood; Boidae; Copper; Erythrocytes; Fasting; Feeding Behavior; Folic Acid; gamma-Glutamyl Hydrolase; Hematocrit; Homocysteine; Micronutrients; Pyridoxal Phosphate; Vitamin B 12; Zinc | 2001 |
Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum.
Topics: Adenomatous Polyps; Aged; Colorectal Neoplasms; Cross-Sectional Studies; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Hyperplasia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Smoking | 2001 |
Homocysteine modulation as a reason for continuous folic acid supplementation in methotrexate-treated rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Homocysteine; Humans; Methotrexate; Myocardial Ischemia | 2001 |
Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients.
Topics: Adult; Aged; Dialysis; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Kidney Failure, Chronic; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Peritoneal Dialysis; Polymorphism, Genetic; Renal Dialysis; Vitamin B 12 | 2001 |
Relationships between homocysteine and related amino acids in chronic hemodialysis patients.
Topics: Amino Acids; Erythrocytes; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Renal Dialysis; Vitamin B 12 | 2001 |
Lifestyle factors and plasma homocysteine concentrations in a general population sample.
Topics: Adult; Aged; Alcohol Drinking; Analysis of Variance; Coffee; Cross-Sectional Studies; Diet; Diet Surveys; Exercise; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Linear Models; Male; Middle Aged; Netherlands; Sampling Studies; Smoking; Surveys and Questionnaires; Vitamin B Complex | 2001 |
Homocysteine concentrations in a German cohort of 500 individuals: reference ranges and determinants of plasma levels in healthy children and their parents.
Topics: Adolescent; Adult; Age Factors; Body Weight; Child; Creatine; Creatinine; Female; Folic Acid; Germany; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Reference Values; Sex Factors; Vitamin B 12 | 2001 |
Hyperhomocysteinemia in dementia.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Dementia, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mental Status Schedule; Pilot Projects; Reference Values; Regression Analysis; Risk Factors; Vitamin B 12 | 2000 |
A population study of the influence of beer consumption on folate and homocysteine concentrations.
Topics: Adult; Aged; Alcohol Drinking; Beer; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Czech Republic; Female; Fluorescence; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2001 |
Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine.
Topics: Adult; Aged; Biomarkers; Creatinine; Cross-Sectional Studies; Cystatin C; Cystatins; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Korea; Male; Middle Aged; Regression Analysis | 2001 |
Plasma homocysteine is not subject to seasonal variation.
Topics: Adolescent; Adult; Diet; Erythrocytes; Fasting; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Seasons; Vitamin B Complex | 2001 |
Terminal ileum resection is associated with higher plasma homocysteine levels in Crohn's disease.
Topics: Adult; Blood Sedimentation; Creatinine; Crohn Disease; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Ileum; Male; Thrombophilia; Vitamin B 12 | 2001 |
Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Methylmalonic Acid; Middle Aged; Prevalence; Surveys and Questionnaires; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Mild hyperhomocysteinemia: vitamin supplementation or not?
Topics: Adult; Case-Control Studies; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Mutation; Polymorphism, Genetic; Vascular Diseases; Vitamins | 2001 |
Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Albuminuria; Blood Glucose; Coronary Disease; Creatinine; Fasting; Female; Folic Acid; Glucose Tolerance Test; Homocysteine; Humans; Insulin; Insulin Resistance; Male; Massachusetts; Middle Aged; Risk Factors; Sex Factors; Vitamin B 12 | 2001 |
Homocysteine and folate levels in postmenopausal women.
Topics: Adult; Age Distribution; Age Factors; Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Menopause; Middle Aged; Smoking; Time Factors | 2001 |
[Effect of vitamin B6, B12 and folic acid levels on basal blood homocysteine values and after methionine load].
Topics: Folic Acid; Homocysteine; Humans; Methionine; Middle Aged; Vitamin B 12; Vitamin B 6 | 2001 |
A statement of homocyst(e)ine and cardiovascular disease.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Pyridoxine; Risk Factors; Vitamin B 12 | 2001 |
[Plasma homocysteine levels in patients with ischemic heart disease].
Topics: Aged; Drug Administration Schedule; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Ischemia; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors; Vitamin B 12; Vitamin B 6 | 2001 |
The effect of polymorphisms of MTHER gene and vitamin B on hyperhomocysteinemia.
Topics: Aged; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymorphism, Restriction Fragment Length; Vitamin B 12 | 2001 |
Folate homeostasis and antiproliferative activity of folates and antifolates.
Topics: Animals; Caco-2 Cells; Cell Division; Colonic Neoplasms; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homeostasis; Homocysteine; Humans; Kinetics; Mice; Risk Factors | 2001 |
Assessment of nutritional folate status and selected vitamin status of women of childbearing age.
Topics: Adolescent; Adult; Ascorbic Acid; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Nutrition Assessment; Nutrition Disorders; Nutritional Status; Poland; Seroepidemiologic Studies; Vitamin A; Vitamin B 12; Vitamin E; Vitamins | 2001 |
Folate supplementation inhibits intimal hyperplasia induced by a high-homocysteine diet in a rat carotid endarterectomy model.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Endarterectomy, Carotid; Folic Acid; Homocysteine; Hyperplasia; Rats; Rats, Sprague-Dawley; Tunica Intima | 2001 |
Plasma homocysteine levels in obstructive sleep apnea: association with cardiovascular morbidity.
Topics: Adult; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Ischemia; Pyridoxine; Risk Factors; Sleep Apnea Syndromes | 2001 |
Homocysteine, vitamins and gene mutations in peripheral arterial disease.
Topics: Adult; Aged; Arterial Occlusive Diseases; Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peripheral Vascular Diseases; Vitamin B 12 | 2001 |
Nutrition and metabolism.
Topics: Arteriosclerosis; Coffee; Dietary Supplements; Folic Acid; Homocysteine; Humans; Nutritional Physiological Phenomena | 2001 |
One-carbon metabolism and other biochemical correlates of cognitive impairment as visualized by principal component analysis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Atrophy; Brain; Cognition Disorders; Dementia, Vascular; Diagnosis, Differential; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Reference Values; Severity of Illness Index; tau Proteins; Vitamin B 12 | 2001 |
Homocysteine, HIV, and heart disease.
Topics: Diet; Folic Acid; Heart Diseases; HIV Infections; Homocysteine; Humans; Vitamin B 12 | 2001 |
The relationship among homocysteine, creatinine clearance, and albuminuria in patients with type 2 diabetes.
Topics: Aged; Albuminuria; Creatinine; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Male; Metabolic Clearance Rate; Middle Aged; Regression Analysis; Vitamin B 12 | 2001 |
COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk.
Topics: Breast Neoplasms; Case-Control Studies; Catechol O-Methyltransferase; Cysteine; Estrogens, Catechol; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylation; Micronutrients; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Pyridoxal Phosphate; Risk Factors; S-Adenosylmethionine; Vitamin B 12 | 2001 |
Determinants of homocysteine during weight reduction in obese children and adolescents.
Topics: Adolescent; Age Factors; Body Composition; Body Mass Index; C-Peptide; Child; Folic Acid; Homocysteine; Humans; Methionine; Obesity; Regression Analysis; Time Factors; Weight Loss | 2001 |
Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia.
Topics: Aged; Alanine; Dementia; Female; Folic Acid; Homocysteine; Humans; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Valine; Vitamin B 12 | 2001 |
Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake?
Topics: Dementia, Vascular; Diet; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Models, Biological; Models, Chemical; Neopterin; Oxidative Stress; Oxygen; Vascular Diseases; Vitamin B 12 | 2001 |
Hyperhomocysteinemia in advanced age.
Topics: Aged; Aging; Chronic Disease; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Time Factors; Vitamin B 6 | 2001 |
Genetic defects as important factors for moderate hyperhomocysteinemia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Age Factors; Aged; Aged, 80 and over; Cystathionine; DNA Mutational Analysis; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Risk Factors; Sex Factors; Vitamin B 12; Vitamin B 6 | 2001 |
Heterogeneity of the association between plasma homocysteine and atherothrombotic disease: insights from studies of vascular structure and function.
Topics: Arteries; Endothelium, Vascular; Folic Acid; Heart Diseases; Homocysteine; Humans; Nitric Oxide; Risk Factors; Thrombosis; Vasodilation | 2001 |
Homocysteine in cerebrovascular disease: an independent risk factor for subcortical vascular encephalopathy.
Topics: Aged; Arteries; Case-Control Studies; Cerebrovascular Disorders; Dementia, Vascular; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Risk Factors; Vitamin B 12; Vitamin B 6 | 2001 |
Does a single vitamin B-supplementation induce functional vitamin B-deficiency?
Topics: Adult; Cystathionine; Cysteine; Dietary Supplements; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Methionine; Methylmalonic Acid; Middle Aged; Models, Biological; Pilot Projects; Time Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2001 |
Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered?
Topics: Adolescent; Adult; Biomarkers; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Nepal; Nutritional Status; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
CblC/D defect combined with haemodynamically highly relevant VSD.
Topics: Female; Folic Acid; Heart Septal Defects, Ventricular; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Infant, Newborn; Lactic Acid; Metabolism, Inborn Errors; Methionine; Methylmalonic Acid | 2001 |
Hyperhomocysteinemia and hyperlipidemia in coronary heart disease.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases; Point Mutation; Risk Factors; Vitamin B 12 | 1999 |
Effects of homocysteine on proliferation, necrosis, and apoptosis of vascular smooth muscle cells in culture and influence of folic acid.
Topics: Apoptosis; Cell Culture Techniques; Cell Division; Cell Line; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Muscle, Smooth, Vascular; Necrosis | 2001 |
Antiepileptic drugs as independent predictors of plasma total homocysteine levels.
Topics: Adult; Amino Acid Substitution; Anticonvulsants; Cholesterol; Cholesterol, HDL; Confidence Intervals; Cysteine; Epilepsy; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Mutation; Predictive Value of Tests; Prevalence; Statistics, Nonparametric; Threonine; Triglycerides; Vitamin B 12 | 2001 |
Determinants of increased plasma homocysteine in 221 stable liver transplant patients.
Topics: Comorbidity; Cyclosporine; Female; Folic Acid; Homocysteine; Humans; Immunosuppressive Agents; Life Style; Liver Transplantation; Male; Prevalence; Risk Factors; Tacrolimus; Vitamin B 12 | 2001 |
Single nucleotide polymorphism (SNP) genotyping in unprocessed whole blood and serum by real-time PCR: application to SNPs affecting homocysteine and folate metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Polymorphism, Single Nucleotide | 2001 |
Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; DNA; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Kidney Diseases; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Peritoneal Dialysis; Point Mutation; Polymorphism, Restriction Fragment Length; Renal Dialysis; Vitamin B 12 | 2001 |
Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Catalase; Cell Division; DNA Fragmentation; DNA, Neoplasm; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Homocysteine; Humans; Hydrogen Peroxide; Malondialdehyde; Methionine; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Transcription Factors; Tumor Cells, Cultured | 2001 |
Proteinuria and plasma total homocysteine levels in chronic renal disease patients with a normal range serum creatinine: critical impact of true glomerular filtration rate.
Topics: Adult; Aged; Chronic Disease; Creatinine; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Proteinuria; Pyridoxal Phosphate; Serum Albumin; Vitamin B 12 | 2001 |
Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis.
Topics: Adolescent; Adult; Aged; Child; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Risk Factors; Venous Thrombosis; Vitamin B 12; Vitamin B 6 | 2001 |
Plasma homocysteine level in relation to folate and vitamin B6 status in apparently normal men.
Topics: Adult; Body Mass Index; Diet, Vegetarian; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Middle Aged; Vitamin B 6; Vitamin B 6 Deficiency | 2001 |
Human cobalamin deficiency: alterations in serum tumour necrosis factor-alpha and epidermal growth factor.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Hypochromic; Anemia, Megaloblastic; Animals; Bone Marrow; Epidermal Growth Factor; Female; Folic Acid; Follow-Up Studies; Gastritis, Atrophic; Homocysteine; Humans; Iron; Iron Deficiencies; Male; Middle Aged; Peripheral Nervous System Diseases; Rats; Species Specificity; Tumor Necrosis Factor-alpha; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine.
Topics: Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Sensitivity and Specificity; Vitamin B 12 | 2001 |
Cardiovascular disease risk factors and diet of Fulani pastoralists of northern Nigeria.
Topics: Adolescent; Adult; Aged; Body Composition; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Diet; Dietary Fats; Electric Impedance; Energy Intake; Exercise; Female; Folic Acid; Food Analysis; Homocysteine; Humans; Lipids; Male; Mental Recall; Middle Aged; Nigeria; Risk Factors; Surveys and Questionnaires; Vitamin B 12 | 2001 |
Changes in plasma homocysteine in arthritis patients starting treatment with low-dose methotrexate subsequently supplemented with folic acid.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Risk Factors | 2001 |
Total homocysteine is making its way into pediatric laboratory diagnostics.
Topics: Adult; Avitaminosis; Child; Diagnosis, Differential; Female; Folic Acid; Folic Acid Deficiency; HIV Infections; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Infant, Newborn; Male; Methylmalonic Acid; Pediatrics; Pregnancy; Vitamin B 12 | 2001 |
Interplay between methylenetetrahydrofolate reductase gene polymorphism 677C-->T and serum folate levels in determining hyperhomocysteinemia in heart transplant recipients.
Topics: Adult; Aged; Coronary Artery Disease; Female; Folic Acid; Genotype; Heart Transplantation; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Function Tests; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Postoperative Complications; Prognosis; Risk Factors | 2001 |
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia, and cardiovascular diseases in chronic hemodialysis patients.
Topics: Adult; Aged; Cardiovascular Diseases; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidoreductases Acting on CH-NH Group Donors; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Renal Dialysis; Risk Factors; Statistics as Topic; Vitamin B 12 | 2002 |
Assessment of prothrombotic risk in patients with Behçet's disease should include homocysteine plasma levels.
Topics: Behcet Syndrome; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Thromboembolism; Vitamin B 12; Vitamin B 6 | 2001 |
Plasma total homocysteine and subarachnoid haemorrhage in a co-factor replete population.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Incidence; Male; Middle Aged; Prospective Studies; Subarachnoid Hemorrhage; Vitamin B 12 | 2001 |
Folate reduces homocysteine levels and lowers rate of restenosis.
Topics: Coronary Artery Disease; Folic Acid; Homocysteine; Humans; Secondary Prevention; Stents | 2001 |
Cost-effectiveness of homocysteine-lowering therapy to prevent coronary heart disease.
Topics: Coronary Artery Disease; Cost-Benefit Analysis; Dietary Supplements; Folic Acid; Homocysteine; Humans; Vitamins | 2002 |
Cost-effectiveness of homocysteine-lowering therapy to prevent coronary heart disease.
Topics: Coronary Artery Disease; Cost-Benefit Analysis; Dietary Supplements; Folic Acid; Homocysteine; Humans; Vitamins | 2002 |
Cost-effectiveness of homocysteine-lowering therapy to prevent coronary heart disease.
Topics: Coronary Artery Disease; Cost-Benefit Analysis; Dietary Supplements; Folic Acid; Homocysteine; Humans; Vitamins | 2002 |
Plasma folate but not vitamin B(12) or homocysteine concentrations are reduced after short-term vitamin B(6) supplementation.
Topics: Adult; Area Under Curve; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Pyridoxal Phosphate; Pyridoxine; Vitamin B 12; Vitamin B 6 | 2001 |
Diet-induced mild hyperhomocysteinemia and increased salt intake diminish vascular endothelial function in a synergistic manner.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Pressure; Carotid Artery, Common; Drug Synergism; Endothelium, Vascular; Folic Acid; Heart Rate; Homocysteine; Hyperhomocysteinemia; Japan; Kidney; Lipid Peroxidation; Lipids; Male; Methionine; Natriuresis; Nitrites; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sodium Chloride, Dietary | 2002 |
MTRR and MTHFR polymorphism: link to Down syndrome?
Topics: Alleles; Case-Control Studies; Child; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Vitamin B 12 | 2002 |
Homocysteine levels in elderly Spanish people: influence of pyridoxine, vitamin B12 and folic acid intakes.
Topics: Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Diet Records; Female; Folic Acid; Geriatric Assessment; Homocysteine; Humans; Male; Prospective Studies; Pyridoxine; Spain; Vitamin B 12 | 2002 |
Polymorphisms in genes involved in folate metabolism as risk factors for NTDs.
Topics: Adult; Carrier Proteins; Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Italy; Male; Membrane Proteins; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy | 2001 |
Plasma, liver and kidney folate and plasma homocysteine concentrations are poor response variables at very low dietary folate intakes, in a folate depletion/repletion rat model.
Topics: Animals; Biological Availability; Biomarkers; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Kidney; Liver; Male; Models, Animal; Random Allocation; Rats; Rats, Wistar; Weaning | 2002 |
Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores.
Topics: Adult; Amino Acids; Cardiovascular Diseases; Diet, Vegetarian; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Nutritional Status; Regression Analysis; Risk Factors; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency | 2002 |
The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene.
Topics: Cohort Studies; Cross-Sectional Studies; Fasting; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Riboflavin | 2002 |
The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people.
Topics: Aged; Cardiovascular Diseases; Chile; Cholesterol, HDL; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Male; Nutritional Status; Prevalence; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 2002 |
Fortification of food with vitamin B12 in addition to folic acid might reduce cardiovascular disease risk.
Topics: Cardiovascular Diseases; Folic Acid; Food, Fortified; Homocysteine; Humans; Ireland; United Kingdom; Vitamin B 12 | 2002 |
Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations.
Topics: Aged; Aging; Cystathionine beta-Synthase; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Sex Characteristics; Smoking; Vitamins | 2001 |
Total homocysteine and cognitive deterioration in people with type 2 diabetes.
Topics: Aged; Albuminuria; Cholesterol; Cognition; Cognition Disorders; Diabetes Mellitus, Type 2; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Lipoproteins; Male; Middle Aged; Triglycerides; Vitamin B 12 | 2002 |
Effect of folic acid supplements on homocysteine concentration in plasma of gestating sows.
Topics: Animals; Dietary Supplements; Female; Folic Acid; Homocysteine; Pregnancy; Pregnancy, Animal; Random Allocation; Swine | 2001 |
Micro- and macrovascular complications and hyperhomocysteinaemia in type 1 diabetic patients.
Topics: Adult; Aging; Blood Pressure; Cholesterol; Cholesterol, HDL; Creatinine; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Retinopathy; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Regression Analysis; Time Factors | 2001 |
Plasma homocysteine concentrations in a population of rhesus monkeys (Macaca mulatta): reference ranges and accompanying plasma concentrations of folate and vitamin B12.
Topics: Animals; Female; Folic Acid; Homocysteine; Macaca mulatta; Male; Reference Values; Thiamine | 2002 |
[Relationship between folate, vitamin B12, total plasma homocysteine and mutation of reductase].
Topics: Adult; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Vitamin B 12 | 2000 |
Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats.
Topics: Animals; Electrocardiography; Endocardium; Endothelium, Vascular; Fibrosis; Folic Acid; Heart Ventricles; Homocysteine; Hypertension; Hypertrophy, Left Ventricular; Matrix Metalloproteinases; Myocardium; Rats; Rats, Inbred SHR; Rats, Wistar; Ventricular Function, Left | 2002 |
[Effects of homocysteine on cardiovascular development in early chicken embryo].
Topics: Animals; Cardiovascular System; Chick Embryo; Folic Acid; Heart Defects, Congenital; Homocysteine; Vitamin B 12 | 1999 |
Relation of homocysteine, vitamin B(12), and folate to coronary in-stent restenosis.
Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Disease; Coronary Restenosis; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Factors; Stents; Vitamin B 12 | 2002 |
Nationwide folate fortification has complex ramifications and requires careful monitoring over time.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Myocardial Ischemia; United States | 2002 |
Effects of hormone replacement therapy and methylenetetrahydrofolate reductase polymorphism on plasma folate and homocysteine levels in postmenopausal Japanese women.
Topics: Adult; Aged; Aged, 80 and over; Apolipoproteins; DNA; Estrogens; Female; Folic Acid; Homocysteine; Hormone Replacement Therapy; Humans; Japan; Lipids; Medroxyprogesterone Acetate; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Polymorphism, Genetic; Progesterone Congeners; Regression Analysis | 2002 |
Folate status assessment and folic acid supplements in sickle cell disease.
Topics: Anemia, Sickle Cell; Dietary Supplements; Erythrocytes; Folic Acid; Homocysteine; Humans; Nutritional Status | 2001 |
In praise of folic acid.
Topics: Alzheimer Disease; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Spinal Dysraphism; United States | 2002 |
Plasma homocysteine is not a major risk factor for vascular disease in growth hormone deficient adults.
Topics: Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Creatinine; Female; Folic Acid; Growth Hormone; Homocysteine; Humans; Lipids; Male; Middle Aged; Risk Factors; Statistics, Nonparametric; Vitamin B 12 | 2001 |
Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of young people aged 4-18 years, and a comparison with the survey of people aged 65 years and over.
Topics: Adolescent; Aged; Aging; Biomarkers; Child; Child, Preschool; Cysteine; Diet Surveys; Dipeptides; Female; Folic Acid; Homocysteine; Humans; Male; Reference Values; Seasons; Sex Factors; Smoking; United Kingdom; Vitamin B 12; Vitamin B 6 | 2002 |
Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C-->T variant.
Topics: Female; Fetal Blood; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Labor, Obstetric; Methylenetetrahydrofolate Reductase (NADPH2); Osmolar Concentration; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Vitamin B 12 | 2002 |
Usefulness of plasma vitamin B(6), B(12), folate, homocysteine, and creatinine in predicting outcomes in heart transplant recipients.
Topics: Adult; Biomarkers; Creatinine; Female; Folic Acid; Heart Transplantation; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Survival Analysis; Thrombosis; Vitamin B 12; Vitamin B 6 | 2002 |
Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease.
Topics: Aged; Case-Control Studies; Coronary Disease; Cysteine; Dipeptides; Female; Folic Acid; Homocysteine; Humans; Lipoproteins, VLDL; Male; Middle Aged; Risk Factors; Triglycerides; Vitamin B 12 | 2002 |
Homocysteine and atheromatous renal artery stenosis.
Topics: Aged; Alleles; Arteriosclerosis; Case-Control Studies; Cystathionine beta-Synthase; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Renal Artery Obstruction; Risk Factors; Vitamin B 12 | 2001 |
Serum folate and homocysteine levels in head and neck squamous cell carcinoma.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Progression; Female; Folic Acid; Head and Neck Neoplasms; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Smoking | 2002 |
Optimization of folic acid, vitamin B(12), and vitamin B(6) supplements in pediatric patients with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Child; Dietary Supplements; Erythrocytes; Female; Folic Acid; Hemoglobin SC Disease; Homocysteine; Humans; Male; Nutrition Policy; Vitamin B 12; Vitamin B 6 | 2002 |
Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico.
Topics: Aged; Case-Control Studies; Diet; Female; Folic Acid; Genotype; Hematinics; Homocysteine; Humans; Incidence; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mouth Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Puerto Rico; Registries; Risk Factors; Smoking | 2002 |
[Homocysteine, methylenetetrahydrofolate reductase/C677T genotype and risk for coronary heart disease. The AtheroGene study].
Topics: Case-Control Studies; Coronary Disease; Female; Folic Acid; Genotype; Germany; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prevalence; Risk Factors; Vitamin B 12 | 2002 |
[Homocysteine-induced neural tube defects in chick embryos and protection of folic acid].
Topics: Animals; Apoptosis; Chick Embryo; Folic Acid; Homocysteine; Neural Tube Defects; Teratogens | 1998 |
Homocysteine modifies development of neurulation and dorsal root ganglia in chick embryos.
Topics: Animals; Chick Embryo; Dose-Response Relationship, Drug; Folic Acid; Ganglia, Spinal; Homocysteine | 2002 |
Folic acid treatment reduces chemokine release from peripheral blood mononuclear cells in hyperhomocysteinemic subjects.
Topics: Adult; Aged; Case-Control Studies; Chemokine CCL5; Chemokine CXCL1; Chemokine CXCL5; Chemokines; Chemokines, CXC; Chemotactic Factors; Female; Folic Acid; Growth Substances; Homocysteine; Humans; Hyperhomocysteinemia; Intercellular Signaling Peptides and Proteins; Interleukin-8; Leukocytes, Mononuclear; Male; Middle Aged | 2002 |
Fortification of flour with folic acid. Fortification is needed now.
Topics: Flour; Folic Acid; Food, Fortified; Homocysteine; Humans; Neural Tube Defects | 2002 |
Premature arterial and venous events in three families. Effect of folate levels and MTHFR mutation mediated by family/generation and homocysteine levels.
Topics: Adolescent; Adult; Cardiovascular Diseases; Family Health; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Italy; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Pedigree | 2002 |
Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model.
Topics: Animals; Body Weight; Cleft Palate; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Male; Mice; Mice, Inbred ICR; Neural Tube Defects; Pregnancy | 2002 |
Homocysteine, B vitamin status, and cognitive function in the elderly.
Topics: Aged; Aging; Cognition; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Intelligence; Male; Psychological Tests; Vitamin B 12 | 2002 |
Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor.
Topics: Aged; Cimetidine; Creatinine; Enzyme Inhibitors; Female; Folic Acid; Gastroesophageal Reflux; Histamine H2 Antagonists; Homocysteine; Humans; Methylmalonic Acid; Omeprazole; Proton Pump Inhibitors; Vitamin B 12; Vitamin B 12 Deficiency | 2002 |
Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients.
Topics: Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Renal Dialysis; Vitamin B 12; Vitamin B 12 Deficiency | 2002 |
Hyperhomocyst(e)inemia and MTHFR C677T genotypes in patients with central retinal vein occlusion.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Retinal Vein Occlusion; Retrospective Studies; Risk Factors; Vitamin B 12 | 2002 |
Homocysteine may raise Alzheimer's risk. Keep homocysteine levels in check by getting enough folic acid in your diet.
Topics: Aged; Alzheimer Disease; Biomarkers; Folic Acid; Homocysteine; Humans | 2002 |
Relation of Helicobacter pylori infection to plasma vitamin B12, folic acid, and homocysteine levels in patients who underwent diagnostic coronary arteriography.
Topics: Aged; Coronary Angiography; Coronary Artery Disease; Female; Folic Acid; Gastritis, Atrophic; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Malabsorption Syndromes; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2002 |
Effect of vegetarian diet on homocysteine levels.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Luminescent Measurements; Male; Middle Aged; Prevalence; Vitamin B 12 | 2002 |
Genetic and molecular control of folate-homocysteine metabolism in mutant mice.
Topics: Animals; Blotting, Northern; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; Liver; Methylmalonic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Oligonucleotide Array Sequence Analysis; Signal Transduction | 2002 |
Treatment of hyperhomocysteinemia with folic acid: effects on homocysteine levels, coagulation status, and oxidative stress markers.
Topics: Aged; Analysis of Variance; Biomarkers; Blood Coagulation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Oxidative Stress | 2002 |
Prevalence of hyperhomocysteinemia in an elderly population.
Topics: Age Distribution; Aged; Aged, 80 and over; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Prevalence; Sex Distribution; Vitamin B 12 | 2002 |
The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center.
Topics: Adult; Chi-Square Distribution; Female; Folic Acid; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Renal Dialysis; Statistics, Nonparametric; Vitamin B 12 | 2002 |
Folic acid, Vitamin B(12), and homocysteine in smoking and non-smoking pregnant women.
Topics: Cross-Sectional Studies; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Hyperhomocysteinemia; Nutritional Status; Pregnancy; Pregnancy Complications; Reference Values; Smoking; Vitamin B 12 | 2002 |
[Total plasma homocysteine levels. Relationship with plasmatic folic acid levels and 677C T polymorphism of 5,10-methylenetetrahydrofolate reductase].
Topics: Adolescent; Child; Child, Preschool; Cytosine; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Polymorphism, Genetic; Regression Analysis; Tyrosine | 2002 |
The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort.
Topics: Age Factors; Antigens, Surface; Carboxypeptidases; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Homozygote; Humans; Male; Middle Aged; Mutation; Polymorphism, Genetic; Sex Factors | 2002 |
Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in rats.
Topics: Adjuvants, Immunologic; Animals; Cytotoxicity, Immunologic; Folic Acid; Folic Acid Deficiency; Homocysteine; Killer Cells, Natural; Liver; Lymphocyte Subsets; Male; Neoplasms; Rats; Rats, Sprague-Dawley | 2002 |
Hyperhomocyst(e)inemia, but not methylenetetrahydrofolate reductase C677T mutation, as a risk factor in branch retinal vein occlusion.
Topics: Adult; Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2002 |
A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.
Topics: Aged; Coronary Artery Disease; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors | 2002 |
Homocysteine, folate, methylene tetrahydrofolate reductase genotype and vascular morbidity in diabetic subjects.
Topics: Adult; Aged; Analysis of Variance; Coronary Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Stroke | 2002 |
Erythrocyte mean cellular volume and its relation to serum homocysteine, vitamin B12 and folate.
Topics: Cerebrovascular Disorders; Erythrocyte Volume; Female; Folic Acid; Hemodynamics; Hemoglobins; Homocysteine; Humans; Male; Middle Aged; Vascular Diseases; Vitamin B 12 | 2002 |
Vitamin B12 and folate after 5-12 years of continent ileal urostomy (Kock reservoir) in children and adolescents.
Topics: Adolescent; Child; Child Welfare; Colonic Pouches; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Glomerular Filtration Rate; Hemoglobins; Homocysteine; Humans; Ileum; Iron; Kidney; Male; Methylmalonic Acid; Postoperative Complications; Prospective Studies; Time Factors; Ureterostomy; Urinary Reservoirs, Continent; Vitamin B 12; Vitamin B 12 Deficiency | 2002 |
Reduced plasma homocysteine in obese red wine consumers: a potential contributor to reduced cardiovascular risk status.
Topics: Adult; Alcohol Drinking; Alcoholic Beverages; Beer; Cardiovascular Diseases; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Obesity, Morbid; Risk; Vitamin B 12; Wine | 2002 |
Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India.
Topics: Adult; Anthropometry; Blood Chemical Analysis; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Mental Recall; Obesity; Poverty Areas; Seroepidemiologic Studies; Urban Population; Vitamin B 12 | 2002 |
Endothelial dysfunction relates to folate status in children and adolescents with type 1 diabetes.
Topics: Adolescent; Biomarkers; Blood Glucose; Blood Pressure; Brachial Artery; Child; Child, Preschool; Diabetes Mellitus, Type 1; Endothelium, Vascular; Folic Acid; Glycated Hemoglobin; Homocysteine; Homocystine; Humans; Nitroglycerin; Reference Values; Triglycerides; Vasodilation | 2002 |
Homocysteine and C-reactive protein levels in haemodialysis patients.
Topics: Adult; C-Reactive Protein; Case-Control Studies; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Vitamin B 12 | 2001 |
Vitamin B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate reductase polymorphisms.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Forecasting; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Osmolar Concentration; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Regression Analysis; Vitamin B 12 | 2002 |
Homocysteine levels in patients with Raynaud's phenomenon.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Raynaud Disease; Reference Values; Vitamin B 12 | 2002 |
Endothelial function in healthy younger and older hyperhomocysteinemic subjects.
Topics: Adolescent; Adult; Age Factors; Aged; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Vasodilation; Vitamin B 12 | 2002 |
Hyperhomocysteinemia and cobalamin deficiency in young Asian Indians in the United States.
Topics: Adult; Diet, Vegetarian; Female; Folic Acid; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Hyperhomocysteinemia; India; Malabsorption Syndromes; Male; Sex Factors; United States; Vitamin B 12; Vitamin B 12 Deficiency | 2002 |
[Formulation of tablets decreasing plasma homocysteine levels].
Topics: Cellulose; Folic Acid; Homocysteine; Humans; Reproducibility of Results; Tablets; Vitamin B 12; Vitamin B 6 | 2001 |
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.
Topics: Animals; DNA; DNA Methylation; Ethanol; Folic Acid; Folic Acid Deficiency; Homocysteine; Lipid Peroxidation; Liver; Male; Methionine; Oxidation-Reduction; Swine; Swine, Miniature | 2002 |
Effect of supplementation with folic-acid on relation between plasma homocysteine, folate, and vitamin B12.
Topics: Aged; Case-Control Studies; Dementia; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Transcobalamins; Vitamin B 12 | 2002 |
Folate supplementation after heart transplantation: effects on homocysteine plasma levels and allograft vascular disease.
Topics: Coronary Angiography; Creatinine; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Heart Transplantation; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prospective Studies; Time Factors; Transplantation, Homologous; Vascular Diseases | 2002 |
Plasma homocysteine and cognitive impairment in an older British African-Caribbean population.
Topics: Aged; Black or African American; Black People; Caribbean Region; Chi-Square Distribution; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Logistic Models; London; Male; Middle Aged; Sampling Studies; Socioeconomic Factors; White People | 2002 |
[Investigation of relationship between pregnancy induced hypertension syndrome and homocysteine, folic acid and vitamin B(12)].
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Vitamin B 12 | 2002 |
Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12.
Topics: Adolescent; Adult; Biomarkers; Cross-Sectional Studies; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Nutritional Status; Pregnancy; Regression Analysis; Vitamin B 12 | 2002 |
Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years.
Topics: Celiac Disease; Cohort Studies; Energy Intake; Female; Folic Acid; Glutens; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Remission Induction; Vitamin B 12; Vitamins | 2002 |
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses.
Topics: Animals; Cell Line; Cytoplasm; Deoxyribonucleotides; DNA; Folic Acid; Glycine; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Methylation; S-Adenosylmethionine; Tetrahydrofolates; Thymidine Monophosphate | 2002 |
Folic acid and the elderly.
Topics: Aged; Anemia; Dietary Supplements; Folic Acid; Homocysteine; Humans; Microcirculation; Risk Factors; Vascular Diseases | 2002 |
N-Acetylcysteine, vitamin C and vitamin E diminish homocysteine thiolactone-induced apoptosis in human promyeloid HL-60 cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Ascorbic Acid; Folic Acid; HL-60 Cells; Homocysteine; Humans; Hydrogen Peroxide; Leukemia, Myeloid; Vitamin E | 2002 |
Nutritional and genetic inefficiencies in one-carbon metabolism and cervical cancer risk.
Topics: Carbon; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Neoplasm Invasiveness; Risk Factors; Uterine Cervical Neoplasms | 2002 |
Plasma homocysteine concentration changes after renal transplantation in children.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Male; Serum Albumin; Vitamin B 12 | 2002 |
Effects of an 8-week weight-loss program on cardiovascular disease risk factors and regional body composition.
Topics: Absorptiometry, Photon; Adult; Body Composition; Body Constitution; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Energy Intake; Exercise; Female; Folic Acid; Homocysteine; Humans; Insulin; Leptin; Lipids; Male; Obesity; Risk Factors; Sex Factors; Weight Loss | 2002 |
Oral folic acid improves endothelial dysfunction in cigarette smokers.
Topics: Administration, Oral; Adult; Brachial Artery; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hyperemia; Regional Blood Flow; Smoking; Ultrasonography; Vasodilation | 2002 |
Homocysteine and vascular diseases.
Topics: alpha-Cyclodextrins; Alprostadil; Cyclodextrins; Drug Administration Schedule; Folic Acid; Homocysteine; Humans; Infusions, Intravenous; Raynaud Disease; Scleroderma, Systemic; von Willebrand Factor | 2002 |
[Frequency of hyperhomocysteinemia in hemodialysis patients with folic acid supplementation].
Topics: Adult; Age Factors; Aged; Female; Folic Acid; Hemodiafiltration; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Renal Dialysis; Time Factors; Vitamin B 12 | 2002 |
Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?
Topics: Animals; Female; Fetal Diseases; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy; Prenatal Diagnosis | 2002 |
Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Health Status; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome | 2002 |
Low plasma antioxidants and normal plasma B vitamins and homocysteine in patients with severe obesity.
Topics: Adult; Body Mass Index; Carotenoids; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Obesity; Vitamin B 12; Vitamin E; Vitamins | 2002 |
Methylenetetrahydrofolate reductase gene mutation and hyperhomocysteinemia as a risk factor for coronary heart disease in the Indian population.
Topics: Adult; Coronary Disease; Cystathionine beta-Synthase; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Vitamin B 12 | 2002 |
Serum lipid profiles and risk of cardiovascular disease in three different male populations in northern Nigeria.
Topics: Adult; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Male; Nigeria; Risk Factors; Triglycerides; Vitamin B 12 | 2002 |
Clinical trials testing the homocysteine hypothesis.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Trials as Topic; Edible Grain; Flour; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors | 2002 |
Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.
Topics: Adolescent; Adult; Age Factors; Disease Progression; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Renal Dialysis; Risk Factors | 2002 |
Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chromosome Segregation; Coronary Angiography; Coronary Artery Disease; Family; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pedigree; Vitamin B 12 | 2002 |
The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study.
Topics: Adolescent; Adult; Blood Volume; Dietary Supplements; Fasting; Female; Folic Acid; Gestational Age; Hematocrit; Homocysteine; Humans; Longitudinal Studies; Pregnancy; Serum Albumin | 2002 |
Homocysteine, nutritional status and insulin in renal transplant recipients.
Topics: Blood Glucose; C-Peptide; Creatinine; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Immunosuppressive Agents; Insulin; Kidney Transplantation; Lipids; Male; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Vitamin B 12 | 2002 |
Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.
Topics: Adult; Analysis of Variance; Antigens, Surface; Carboxypeptidases; Cardiovascular Diseases; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Probability; Reference Values; Risk Assessment; Sensitivity and Specificity; Vitamin B 12 | 2002 |
Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese.
Topics: Adult; Age Distribution; Aged; Arteriosclerosis; Cross-Sectional Studies; Data Collection; Female; Folic Acid; Genotype; Homocysteine; Humans; Incidence; Japan; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Probability; Reference Values; Risk Assessment; Sampling Studies; Sensitivity and Specificity; Sex Distribution; Vitamin B 12; Vitamin B 6 | 2002 |
The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr.
Topics: 5' Flanking Region; Animals; Cholates; Disease Models, Animal; Folic Acid; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors | 2002 |
The impact of phenylketonuria on folate metabolism.
Topics: Biopterins; Chromatography, High Pressure Liquid; Coenzymes; Folic Acid; Homocysteine; Humans; Immunoassay; Phenylalanine; Phenylketonurias | 2002 |
Effect of implementation of folic acid fortification of food on homocysteine concentrations in subjects with coronary artery disease.
Topics: Aged; Biomarkers; Blood Pressure; C-Reactive Protein; Coronary Artery Disease; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Regression Analysis; Severity of Illness Index; Treatment Outcome | 2002 |
Content of folic acid and free homocysteine in blood serum of human papillomavirus-infected women with cervical dysplasia.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; DNA Primers; DNA, Viral; Female; Folic Acid; Homocysteine; Humans; Papillomaviridae; Papillomavirus Infections; Polymerase Chain Reaction; Tumor Virus Infections; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2002 |
Hyperhomocysteinemia in children with renal transplants.
Topics: Adolescent; Blood Glucose; Child; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Lipids; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Regression Analysis; Vitamin B 12 | 2002 |
Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels.
Topics: Cohort Studies; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Thymidylate Synthase | 2002 |
Lack of association between plasma homocysteine and inflammation in psychogeriatric patients.
Topics: Aged; C-Reactive Protein; Creatinine; Female; Folic Acid; Homocysteine; Humans; Inflammation; Male; Mental Disorders; Sampling Studies | 2002 |
Acute valproate administration impairs methionine metabolism in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Anticonvulsants; Betaine-Homocysteine S-Methyltransferase; Female; Folic Acid; Glutathione; Glutathione Disulfide; Homocysteine; Liver; Methionine; Methionine Adenosyltransferase; Methyltransferases; Models, Animal; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Teratogens; Valproic Acid; Vitamin B 6 | 2002 |
Folate deficiency alters melatonin secretion in rats.
Topics: Animals; Folic Acid; Folic Acid Deficiency; Homocysteine; Male; Melatonin; Random Allocation; Rats; Rats, Sprague-Dawley | 2002 |
Elevated serum methylmalonic acid concentrations are common among elderly Americans.
Topics: Adult; Aged; Aging; Black or African American; Creatinine; Female; Folic Acid; Hispanic or Latino; Homocysteine; Humans; Male; Methylmalonic Acid; Nutrition Surveys; Vitamin B 12; Vitamin B 12 Deficiency; White People | 2002 |
Homocysteine and other vascular risk factors in patients with phenylketonuria on a diet.
Topics: Child; Child, Preschool; Coronary Artery Disease; Diet, Protein-Restricted; Endothelin-1; Folic Acid; Homocysteine; Humans; Lipids; Nutrition Assessment; Phenylalanine; Phenylketonurias; Risk Factors; Vitamin B 12; Vitamin B 6 | 2002 |
The effect of vitamin B6 and folate supplements on plasma homocysteine and serum lipids levels in patients on regular hemodialysis.
Topics: Adult; Aged; Body Mass Index; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Lipids; Male; Middle Aged; Renal Dialysis; Risk Factors; Vitamin B 6 | 2001 |
Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia.
Topics: Age Factors; Animal Feed; Animals; Choline; Folic Acid; Homocysteine; Hyperhomocysteinemia; Methionine; Nephritis, Interstitial; Rats; Rats, Inbred F344; Weaning | 2002 |
Influence of age, sex, folate and vitamin B12 status on plasma homocysteine in Saudis.
Topics: Adult; Aged; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Saudi Arabia; Sex Characteristics; Vitamin B 12 | 2002 |
Folate levels in pregnant women who smoke: an important gene/environment interaction.
Topics: Adult; Cotinine; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Smoking; Vitamin B 12 | 2002 |
Homocysteine and vascular disease.
Topics: Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Coronary Disease; Dose-Response Relationship, Drug; Folic Acid; Hematinics; Homocysteine; Humans; Pyridines; Thiazepines; Vascular Diseases | 2002 |
Efficacy of a complex multivitamin supplement.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; beta Carotene; Cohort Studies; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lipid Peroxidation; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Pilot Projects; Pyridoxal Phosphate; Pyridoxine; Vitamin B 12; Vitamin E; Vitamins | 2002 |
Smoking and plasma homocysteine.
Topics: Adult; Cardiovascular Diseases; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Smoking; Vitamin B 12; Vitamin B 6 | 2002 |
Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey.
Topics: Adult; Black People; Erythrocytes; Fluorescein Angiography; Folic Acid; Homocysteine; Humans; Macular Degeneration; Nutrition Surveys; Nutritional Status; Odds Ratio; Risk Factors; Vitamin B 12; White People | 2002 |
Optimal use of markers for cobalamin and folate status in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Mental Disorders; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Oxidoreductases Acting on CH-NH Group Donors; Vitamin B 12 | 2002 |
Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hypertension; Insulin Resistance; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prevalence; Risk Factors; Vitamin B 12; Vitamin B 6 | 2002 |
Comparison of two micronutrient supplements in children with chronic renal failure.
Topics: Adolescent; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infant; Kidney Failure, Chronic; Male; Micronutrients; Minerals; Nutritional Status; Odorants; Peritoneal Dialysis; Pilot Projects; Renal Dialysis; Surveys and Questionnaires; Taste; Trace Elements; Vitamins | 2002 |
Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients.
Topics: Age Factors; Aged; Creatinine; Cystatin C; Cystatins; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Male; Mental Disorders; Predictive Value of Tests; Vitamin B 12 | 2002 |
Lowering plasma homocyst(e)ine may affect atherosclerotic disease.
Topics: Arteriosclerosis; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Risk Factors | 2002 |
Homocysteine, folate and vitamin B12 as risk factors for acute myocardial infarction in a Southeast Asian population.
Topics: Adult; Aged; Asian People; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Logistic Models; Male; Middle Aged; Myocardial Infarction; Risk Factors; Seroepidemiologic Studies; Singapore; Vitamin B 12 | 2002 |
Cobalamin status (holo-transcobalamin, methylmalonic acid) and folate as determinants of homocysteine concentration.
Topics: Adult; Aged; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Transcobalamins; Vitamin B 12 | 2002 |
Serum folate and homocysteine levels in head and neck squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Disease Progression; Folic Acid; Head and Neck Neoplasms; Homocysteine; Humans; Hyperhomocysteinemia; Neopterin; Prognosis; Risk Factors | 2002 |
Plasma homocyst(e)ine, folate and vitamin B(12) levels among school children in Taiwan: The Taipei Children Heart Study.
Topics: Adolescent; Analysis of Variance; Anthropometry; Blood Pressure; Cardiovascular Diseases; Child; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Risk Factors; Sex Characteristics; Statistics, Nonparametric; Surveys and Questionnaires; Taiwan; Vitamin B 12 | 2002 |
Lack of association between plasma homocysteine and angiographic coronary artery disease in the era of fortification of cereal grain flour with folic acid.
Topics: Adult; Aged; Coronary Angiography; Coronary Disease; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Severity of Illness Index; Vitamin B 12 | 2002 |
Rethinking a heart-disease risk.
Topics: Diet; Folic Acid; Heart Diseases; Homocysteine; Humans; Research; Risk Assessment; United States | 2002 |
Sustained increases of plasma homocysteine, copper, and serum ceruloplasmin after coronary artery bypass grafting.
Topics: Aged; Cardiopulmonary Bypass; Ceruloplasmin; Copper; Coronary Artery Bypass; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Minimally Invasive Surgical Procedures; Postoperative Complications; Risk Factors; Vitamin B 12 | 2002 |
Hyperhomocysteinaemia and risk of thrombosis in systemic lupus erythematosus patients.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kuwait; Lupus Erythematosus, Systemic; Male; Risk Factors; Thrombosis | 2002 |
Homocysteine, cardiovascular disease risk factors, and habitual diet in the French Supplementation with Antioxidant Vitamins and Minerals Study.
Topics: Adult; Aging; Alcohol Drinking; Antioxidants; Apolipoproteins B; Blood Glucose; Body Constitution; Body Mass Index; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Coffee; Dietary Fiber; Dietary Supplements; Energy Intake; Erythrocytes; Exercise; Fasting; Female; Folic Acid; France; Homocysteine; Humans; Male; Middle Aged; Minerals; Risk Factors; Sex Characteristics; Triglycerides; Vitamin B 12; Vitamin B 6; Vitamins | 2002 |
Preconception homocysteine and B vitamin status and birth outcomes in Chinese women.
Topics: Adult; Body Mass Index; Body Weight; Case-Control Studies; China; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Nutritional Status; Obstetric Labor, Premature; Preconception Care; Pregnancy; Pregnancy Outcome; Prospective Studies; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2002 |
Can homocysteine be related to physical functioning?
Topics: Aged; Aging; Folic Acid; Homocysteine; Humans; Psychomotor Performance; Vitamin B 12; Vitamin B 6 | 2002 |
Association between serum aspartate transaminase and homocysteine levels in hemodialysis patients.
Topics: Aspartate Aminotransferases; Female; Folic Acid; Forecasting; Hepatitis B Antibodies; Hepatitis B Antigens; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Renal Dialysis; Uremia; Vitamin B Complex | 2002 |
Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Models, Biological; Multivariate Analysis; Odds Ratio; Pemetrexed; Time Factors; Vitamin B 12 | 2002 |
Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E.
Topics: Animals; Antioxidants; Apolipoproteins E; Brain; Dietary Fats, Unsaturated; Folic Acid; Homocysteine; Iron, Dietary; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Thiobarbituric Acid Reactive Substances; Vitamin E | 2002 |
Fruit and vegetable intake and chronic disease risk in Portugal.
Topics: Antioxidants; Biomarkers; Cardiovascular Diseases; Carotenoids; Female; Folic Acid; Fruit; Homocysteine; Humans; Male; Middle Aged; Morbidity; Neoplasms; Portugal; Risk Factors; Surveys and Questionnaires; Vegetables; Vitamin B 12; Vitamin B 6; Vitamin E | 2002 |
Moderate hyperhomocysteinaemia and immune activation in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Neopterin; Parkinson Disease; Vitamin B 12 | 2002 |
Plasma total homocysteine, folate, and vitamin B12 status in Korean adults.
Topics: Adult; Age Factors; Aged; Area Under Curve; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Korea; Male; Middle Aged; Nutritional Status; Prevalence; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2002 |
Segmented regression in the presence of covariate measurement error in main study/validation study designs.
Topics: Bias; Data Interpretation, Statistical; Diet Records; Folic Acid; Homocysteine; Humans; Likelihood Functions; Multivariate Analysis; Regression Analysis; Reproducibility of Results; Surveys and Questionnaires | 2002 |
Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project.
Topics: Adult; Cardiovascular Diseases; Case-Control Studies; Europe; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Risk Factors | 2003 |
The effect of folic acid, vitamin B6 and vitamin B12 on the homocysteine levels in rabbits fed by methionine-enriched diets.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Drug Combinations; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rabbits; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2002 |
The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans.
Topics: Adolescent; Adult; Antigens, Surface; Carboxypeptidases; Female; Folic Acid; Glutamate Carboxypeptidase II; Homocysteine; Humans; Male; Middle Aged; Netherlands; Neural Tube Defects; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors | 2003 |
Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
Topics: Anemia; Anemia, Pernicious; Cysteine; Dipeptides; Folic Acid; Glutathione; Homocysteine; Humans; Memory Disorders; Methionine; Movement Disorders; Nervous System Diseases; Retrospective Studies; S-Adenosylmethionine; Sensation Disorders; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Reduction of total homocysteine levels by oral folic acid fails to improve endothelial function in children with chronic renal failure.
Topics: Administration, Oral; Arginine; Child; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Vasodilation | 2003 |
Hyperhomocysteinemia is related to a decreased blood level of vitamin B12 in the second and third trimester of normal pregnancy.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intrinsic Factor; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Receptors, Peptide; Statistics as Topic; Vitamin B 12 | 2002 |
Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.
Topics: Aged; Alleles; Carotid Artery Diseases; Coronary Angiography; Cytosine; DNA; DNA Damage; DNA Mutational Analysis; DNA Primers; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Micronucleus Tests; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Thymidine; Vitamin B 12 | 2003 |
Folate delivers head-to-toe health advantages. The B vitamin that benefits unborn babies may also protect the hearts and minds (and colons) of adults.
Topics: Alzheimer Disease; Anencephaly; Colonic Neoplasms; Female; Folic Acid; Heart Diseases; Homocysteine; Humans; Male; Pregnancy; Spinal Dysraphism; Stroke | 2002 |
Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Middle Aged; Parkinson Disease; Risk Factors; Vitamin B 12 | 2003 |
The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon.
Topics: Animals; Body Weight; Colon; Dietary Supplements; DNA Methylation; Folic Acid; Genome; Hemoglobins; Homocysteine; Rats; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tumor Suppressor Protein p53 | 2003 |
Vitamin B-12 metabolism in HIV-infected patients in the age of highly active antiretroviral therapy: role of homocysteine in assessing vitamin B-12 status.
Topics: Adult; Antiretroviral Therapy, Highly Active; Diagnosis, Differential; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; HIV Infections; Homocysteine; Humans; Hyperhomocysteinemia; Male; Nutrition Assessment; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations.
Topics: Analysis of Variance; Anemia; Biomarkers; Child; Creatinine; Female; Folic Acid; Guatemala; Hematocrit; Hemoglobins; Homocysteine; Humans; Male; Mass Screening; Methylmalonic Acid; Prevalence; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Folate intake, plasma folate and homocysteine status in a random Finnish population.
Topics: Adult; Aged; Biomarkers; Diet; Dietary Supplements; Female; Finland; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors; Vitamin B 12 | 2003 |
Hyperhomocysteinaemia: time to screen and treat?
Topics: Animals; Antioxidants; Child; Evidence-Based Medicine; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; New Zealand; Randomized Controlled Trials as Topic; Risk Factors; Survival Rate; Vitamins | 2002 |
Folate status and a new repletion cut-off value in a group of healthy Majorcan women.
Topics: Adolescent; Adult; Aged; Female; Fluorescence Polarization Immunoassay; Folic Acid; Gene Frequency; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Radioimmunoassay; Reference Values; Spain | 2003 |
CblE type of homocystinuria due to methionine synthase reductase deficiency: clinical and molecular studies and prenatal diagnosis in two families.
Topics: Adult; Anemia, Megaloblastic; Base Sequence; Cells, Cultured; Child; Chromatography, Ion Exchange; DNA; Female; Ferredoxin-NADP Reductase; Fibroblasts; Folic Acid; Homocysteine; Homocystinuria; Humans; Methionine; Molecular Sequence Data; Mutation; Prenatal Diagnosis; Reverse Transcriptase Polymerase Chain Reaction; Serine; Vitamin B 12 | 2002 |
Alzheimer's disease and total plasma aminothiols.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Cysteine; Folic Acid; Glutathione; Homocysteine; Humans; Mental Status Schedule; Neuropsychological Tests; Prognosis; Reference Values; Vitamin B 12 | 2003 |
Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Reference Values; Valproic Acid; Vitamin B 12 | 2003 |
Heterogeneity in the prevalence of methylenetetrahydrofolate reductase gene polymorphisms in women of different ethnic groups.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian; Asian People; Black People; Ethnicity; Female; Folic Acid; Gene Frequency; Genetic Heterogeneity; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mexican Americans; Middle Aged; Mutation; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prevalence; Racial Groups; White People | 2003 |
Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos.
Topics: Animals; Central Nervous System; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Folic Acid; Homocysteine; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Neural Tube Defects; Pregnancy; Pregnancy Complications; Somites; Thymidine | 2003 |
Effect of nutrient supplementation on serum homocysteine, iron and proteins in psychogeriatric patients.
Topics: Aged; Aged, 80 and over; Ascorbic Acid; Dietary Proteins; Dietary Supplements; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Iron; Mental Disorders; Reference Values; Serum Albumin; Vitamin B Complex | 2003 |
Folate status in Germany 1997-2000.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Diet; Diet Records; Dietary Supplements; Erythrocytes; Female; Folic Acid; Food, Fortified; Germany; Homocysteine; Humans; Infant; Male; Middle Aged; Nutritional Status; Pregnancy | 2002 |
Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample.
Topics: Adult; Aged; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Netherlands; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Surveys and Questionnaires | 2003 |
Will caloric restriction and folate protect against AD and PD?
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Brain; Brain-Derived Neurotrophic Factor; Caloric Restriction; Disease Models, Animal; Energy Intake; Folic Acid; Homocysteine; Humans; Middle Aged; Neurons; Oxidative Stress; Parkinson Disease; Rats; Risk Factors | 2003 |
Serum homocysteine level in Behçet's disease.
Topics: Adult; Behcet Syndrome; Case-Control Studies; Female; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Prevalence; Vitamin B 12 | 2002 |
Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women.
Topics: Adult; Diet; Female; Folic Acid; Glycine max; Homocysteine; Humans; Isoflavones; Methionine; Middle Aged; Nutritional Status; Premenopause; Soybean Proteins; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6 | 2003 |
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer.
Topics: Adult; Aged; Alcohol Drinking; Breast Neoplasms; Case-Control Studies; Confidence Intervals; Female; Folic Acid; Homocysteine; Humans; Life Style; Medical History Taking; Middle Aged; Multivariate Analysis; Nurses; Risk Assessment; Risk Factors; Surveys and Questionnaires; United States; Vitamin B 12; Vitamin B 6 | 2003 |
Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss.
Topics: Abortion, Habitual; Adolescent; Adult; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy | 2003 |
Hyperhomocysteinemia in Asian Indians living in the United States.
Topics: Adult; Area Under Curve; Blood Glucose; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Insulin; Male; Middle Aged; United States; Vitamin B 12; White People | 2003 |
Familial hyperhomocysteinemia: multiple venous thrombosis in four generations of a family.
Topics: Adult; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Nitroprusside; Pedigree; Venous Thrombosis; Vitamin B 12; Warfarin | 2003 |
The status of plasma homocysteine and related B-vitamins in healthy young vegetarians and nonvegetarians.
Topics: Adult; Diet, Vegetarian; Dietary Proteins; Female; Folic Acid; Homocysteine; Humans; Male; Nutritional Status; Reference Values; Regression Analysis; Vitamin B 12; Vitamin B 6 | 2003 |
Is there any relationship between lipids and vitamin B levels in persons with elevated risk of atherosclerosis?
Topics: Adult; Aged; Aged, 80 and over; Arteriosclerosis; Cardiac Surgical Procedures; Case-Control Studies; Cholesterol; Female; Folic Acid; Homocysteine; Humans; Hyperlipidemias; Lipids; Male; Middle Aged; Risk Factors; Triglycerides; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2003 |
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Vitamin B 12 | 2003 |
Homocysteine, folate, vitamin B12 levels, and C677T MTHFR mutation in children with renal failure.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Point Mutation; Predictive Value of Tests; Prevalence; Regression Analysis; Vitamin B 12 | 2003 |
5,10-Methylenetetrahydrofolate reductase 677C-->T and 1298A-->C mutations are genetic determinants of elevated homocysteine.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases; Portugal; Prospective Studies | 2003 |
Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994.
Topics: Adult; Aged; Aging; Alcohol Drinking; Alcoholic Beverages; Beer; Black People; Body Mass Index; Cotinine; Dietary Supplements; Erythrocytes; Female; Folic Acid; Health Status; Hispanic or Latino; Homocysteine; Humans; Life Style; Linear Models; Male; Middle Aged; Nutrition Surveys; Sex Characteristics; Vitamin B 12; Vitamins; White People; Wine | 2003 |
Peanut consumption improves indices of cardiovascular disease risk in healthy adults.
Topics: Adult; Arachis; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Diet, Fat-Restricted; Dietary Fats, Unsaturated; Erythrocyte Membrane; Fatty Acids, Monounsaturated; Female; Folic Acid; Homocysteine; Humans; Magnesium; Male; Risk Factors; Triglycerides | 2003 |
Folate deficiency is a common finding in psychogeriatric patients.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylmalonic Acid; Regression Analysis; Vitamin B 12 | 2002 |
Prevalence and mechanisms of hyperhomocysteinemia in elderly hospitalized patients.
Topics: Aged; Aged, 80 and over; Aging; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Nutritional Status; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy.
Topics: Adult; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Hematologic; Retrospective Studies | 2003 |
[Hyperhomocysteinemia hastens myocardial infarct and stroke. Prevention.with leaf salads and vitamins].
Topics: Adult; Age Factors; Aged; Arteriosclerosis; Clinical Trials as Topic; Dementia; Diet; Drug Therapy, Combination; Female; Folic Acid; Fruit; Homocysteine; Humans; Hyperhomocysteinemia; Male; Myocardial Infarction; Prospective Studies; Risk Factors; Sex Factors; Stroke; Vegetables; Vitamin B 12; Vitamin B 6 | 2003 |
Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia.
Topics: Adult; Amino Acid Substitution; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Northern Ireland; Point Mutation; Prospective Studies; Risk Factors; Vitamin B 12 | 2003 |
Serum homocysteine, B12 and folic acid concentration in Thai overweight and obese subjects.
Topics: Adolescent; Adult; Antioxidants; Ascorbic Acid; Body Constitution; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Obesity; Thailand; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2003 |
Plasma total homocysteine in uncomplicated pregnancy and in preeclampsia.
Topics: Case-Control Studies; Chromatography, High Pressure Liquid; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Hyperhomocysteinemia; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Vitamin B 12 | 2003 |
Determinants and distributions of plasma total homocysteine concentrations among school children in Taiwan.
Topics: Adolescent; Age Factors; Anthropometry; Cardiovascular Diseases; Child; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Health Surveys; Homocysteine; Humans; Hyperhomocysteinemia; Male; Risk Factors; Schools; Sex Factors; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
n-3 Fatty acids plus oleic acid and vitamin supplemented milk consumption reduces total and LDL cholesterol, homocysteine and levels of endothelial adhesion molecules in healthy humans.
Topics: Adult; Animals; Antioxidants; Cardiovascular Diseases; Cholesterol; Cholesterol, LDL; Fatty Acids, Omega-3; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Middle Aged; Milk; Oleic Acid; Oxidation-Reduction; Risk Factors; Vascular Cell Adhesion Molecule-1; Vitamin B 6; Vitamin E | 2003 |
Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients.
Topics: Adult; Aged; Antigens, Surface; Carboxypeptidases; Carrier Proteins; Erythrocytes; Female; Folate Receptors, GPI-Anchored; Folic Acid; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Polymorphism, Genetic; Predictive Value of Tests; Receptors, Cell Surface; Renal Dialysis | 2003 |
Hyperhomocysteinemia and vitamin score: correlations with silent brain ischemic lesions and brain atrophy.
Topics: Aged; Aged, 80 and over; Atrophy; Brain; Brain Ischemia; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B 12; Vitamin B 6; Vitamins | 2003 |
Screening for vitamin B-12 and folate deficiency in older persons.
Topics: Age Factors; Aged; Aged, 80 and over; Creatinine; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Male; Mass Screening; Methylmalonic Acid; Prevalence; Reference Values; Risk Factors; Sex Factors; United Kingdom; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation.
Topics: Adult; Area Under Curve; Case-Control Studies; Chronic Disease; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases; Liver Transplantation; Male; Metabolic Clearance Rate; Methionine; Middle Aged; Vitamin B 12; Vitamin B 6 | 2003 |
Homocysteine and other plasma amino acids in preeclampsia and in pregnancies without complications.
Topics: Adult; Amino Acids; Case-Control Studies; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Data Interpretation, Statistical; Female; Folic Acid; Homocysteine; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Vitamin B 12 | 2003 |
Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women.
Topics: Adult; Base Sequence; California; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Gene Deletion; Genetic Variation; Genotype; Hispanic or Latino; Homocysteine; Humans; Medical History Taking; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Policy; Oxidoreductases Acting on CH-NH Group Donors; Time Factors; United States | 2003 |
Betaine supplementation lowers plasma homocysteine in healthy men and women.
Topics: Adult; Betaine; Blood Glucose; Blood Pressure; Body Mass Index; Diet; Dietary Supplements; Eating; Fasting; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Reference Values | 2003 |
Relations between molecular and biological abnormalities in 11 families from siblings affected with methylenetetrahydrofolate reductase deficiency.
Topics: Child; Female; Folic Acid; Genes, Recessive; Homocysteine; Humans; Hyperhomocysteinemia; Male; Metabolism, Inborn Errors; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; RNA Splice Sites | 2003 |
Vitamin B12 and folate status of older New Zealand women.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; New Zealand; Nutritional Status; Prevalence; Vitamin B 12 | 2003 |
Homocysteine concentrations lowered following dietary intervention in an aboriginal community.
Topics: Adult; Cardiovascular Diseases; Cohort Studies; Community Health Services; Diet; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Life Style; Longitudinal Studies; Male; Native Hawaiian or Other Pacific Islander; Racial Groups; Regression Analysis; Risk Factors | 2003 |
Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification.
Topics: Case-Control Studies; Comorbidity; Edible Grain; Female; Folic Acid; Food, Fortified; Homocysteine; Homocystine; Humans; Ischemic Attack, Transient; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Pyridoxal Phosphate; Risk Assessment; Risk Factors; Serum Albumin; Stroke; United States; Vitamin B 12; Vitamin B 6 | 2003 |
Folate and risk of cardiovascular disease. Study results were misinterpreted.
Topics: Cardiovascular Diseases; Cohort Studies; Coronary Disease; Data Interpretation, Statistical; Folic Acid; Homocysteine; Humans; Meta-Analysis as Topic; Risk Factors | 2003 |
Influence of training volume and acute physical exercise on the homocysteine levels in endurance-trained men: interactions with plasma folate and vitamin B12.
Topics: Adult; Exercise; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Physical Endurance; Reference Values; Time Factors; Vitamin B 12 | 2003 |
Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Middle Aged; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Vitamin B 12; Vitamin B 6 | 2003 |
Homocysteine and cerebral infarction in finnish male smokers.
Topics: Aged; Blood Pressure; Case-Control Studies; Cerebral Infarction; Cohort Studies; Confounding Factors, Epidemiologic; Finland; Folic Acid; Homocysteine; Humans; Life Style; Logistic Models; Male; Middle Aged; Odds Ratio; Predictive Value of Tests; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Smoking; Vitamin B 6 | 2003 |
Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients.
Topics: Adult; Alleles; Antigens, Surface; Carrier Proteins; Cross-Sectional Studies; Female; Folic Acid; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Kidney Transplantation; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Polymorphism, Genetic | 2003 |
Folic acid and homocysteine affect neural crest and neuroepithelial cell outgrowth and differentiation in vitro.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Division; Cells, Cultured; Chick Embryo; Epithelial Cells; Folic Acid; Hematinics; Homocysteine; In Vitro Techniques; Necrosis; Neural Crest | 2003 |
Plasma homocysteine and its relationships with atherothrombotic markers in psoriatic patients.
Topics: Acute-Phase Proteins; Adult; Arteriosclerosis; Autoantibodies; Biomarkers; Female; Fibrinogen; Fibronectins; Folic Acid; Homocysteine; Humans; Lipoproteins, LDL; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Psoriasis; Thrombosis; Tissue Plasminogen Activator; Vitamin B 12 | 2003 |
Homocysteine: a marker for cognitive performance? A longitudinal follow-up study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Cognition; Cognition Disorders; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Prospective Studies; Psychomotor Performance; Risk Factors; Vitamin B 12 | 2003 |
Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging.
Topics: Adult; Aging; Alzheimer Disease; Apolipoproteins E; Case-Control Studies; Cholesterol; Educational Status; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Serum Albumin; Smoking; Triglycerides; Vitamin B 6 | 2003 |
Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes.
Topics: Age Factors; Analysis of Variance; Arizona; Biomarkers; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Folic Acid; Homocysteine; Humans; Incidence; Indians, North American; Longitudinal Studies; Male; Middle Aged; Vitamin B 12 | 2003 |
Folate, vitamin B12, and homocysteine status. findings of no relation between human papillomavirus persistence and cervical dysplasia.
Topics: Adolescent; Adult; Cervix Uteri; DNA, Viral; Female; Folic Acid; Homocysteine; Humans; Nutritional Status; Papillomaviridae; Papillomavirus Infections; Tumor Virus Infections; Uterine Cervical Dysplasia; Vitamin B 12 | 2003 |
Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer's disease and mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Apolipoproteins E; Cognition Disorders; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Vitamin B 12 | 2003 |
Serum homocysteine concentrations and their relation to serum folate and vitamin B12 concentrations and coronary artery disease prevalence in an urban, bi-ethnic community.
Topics: Aged; Coronary Artery Disease; Female; Folic Acid; Hispanic or Latino; Homocysteine; Humans; Male; New Mexico; Prospective Studies; Risk Factors; Urban Health; Vitamin B 12; White People | 2003 |
Lipoprotein oxidation, plasma total antioxidant capacity and homocysteine level in patients with multiple sclerosis.
Topics: Adult; Antioxidants; Autoantibodies; Chromans; Female; Folic Acid; Homocysteine; Humans; Lipid Peroxidation; Lipoproteins; Lipoproteins, LDL; Male; Multiple Sclerosis; Oxidation-Reduction; Oxidative Stress; Vitamin B 12; Vitamin E | 2003 |
Folate status and homocysteine level in Italian patients aged under 60 on oral anticoagulant therapy.
Topics: Adolescent; Adult; Anticoagulants; Diet; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; International Normalized Ratio; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Oxidoreductases Acting on CH-NH Group Donors; Thrombosis | 2003 |
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
Topics: Aged; Anxiety Disorders; Cohort Studies; Cross-Sectional Studies; Depressive Disorder; Folic Acid; Genotype; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Norway; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Personality Inventory; Polymorphism, Genetic; Risk Factors; Vitamin B 12 | 2003 |
Serum homocysteine levels are increased in women with gestational diabetes mellitus.
Topics: Adult; Blood Glucose; Blood Pressure; Case-Control Studies; Diabetes, Gestational; Female; Folic Acid; Glucose Tolerance Test; Homocysteine; Humans; Male; Pregnancy; Serum Albumin; Uric Acid; Vitamin B 12 | 2003 |
B vitamins and plasma homocysteine concentrations in an urban and rural area of Costa Rica.
Topics: Adult; Aged; Alcohol Drinking; Blood Pressure; Body Constitution; Body Mass Index; Cardiovascular Diseases; Costa Rica; Diet; Educational Status; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Physical Fitness; Risk Factors; Rural Population; Sex Characteristics; Smoking; Urban Population; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2003 |
Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders.
Topics: Adult; Aged; Folic Acid; Homocysteine; Humans; Mental Disorders; Methylmalonic Acid; Middle Aged; Photometry; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians.
Topics: Adult; Aged; Biomarkers; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylmalonic Acid; Middle Aged; Osmolar Concentration; Transcobalamins; Vitamin B 12 | 2003 |
Severe methylenetetrahydrofolate reductase deficiency, methionine synthase, and nitrous oxide--a cautionary tale.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Anesthetics, Inhalation; Folic Acid; Homocysteine; Humans; Male; Metabolism, Inborn Errors; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Nitrous Oxide; Oxidoreductases; Point Mutation | 2003 |
Adverse effect of nitrous oxide in a child with 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Anesthetics, Inhalation; Cells, Cultured; DNA Mutational Analysis; Fatal Outcome; Fibroblasts; Folic Acid; Genes, Recessive; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Infant; Male; Metabolism, Inborn Errors; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Nitrous Oxide; Oxidoreductases; Point Mutation; Polymorphism, Genetic; RNA | 2003 |
Study on the relationship between plasma homocysteine and acute cerebral vascular disease.
Topics: Cerebral Hemorrhage; Cerebral Infarction; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2000 |
Variations in the lipid profile of patients with chronic renal failure, treated with folic acid.
Topics: Arteriosclerosis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Erythrocytes; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intravenous; Kidney Failure, Chronic; Lipids; Male; Middle Aged; Renal Dialysis; Triglycerides | 2003 |
Plasma homocysteine and glycine are sensitive indices of folate status in a rodent model of folate depletion and repletion.
Topics: Animals; Diet; Egg Yolk; Folic Acid; Folic Acid Deficiency; Glycine; Homocysteine; Liver; Male; Nutritional Status; Rats; Rats, Sprague-Dawley; Weaning | 2003 |
Neural and orofacial defects in Folp1 knockout mice [corrected].
Topics: Animals; Carrier Proteins; Craniofacial Abnormalities; Embryonic and Fetal Development; Female; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation, Developmental; Genetic Markers; Genotype; Homocysteine; Homozygote; Male; Mice; Mice, Knockout; Neural Tube Defects; Receptors, Cell Surface | 2003 |
Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alleles; Data Interpretation, Statistical; Ferredoxin-NADP Reductase; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Nutritional Status; Point Mutation; Polymorphism, Single Nucleotide; Prevalence; Reverse Transcriptase Polymerase Chain Reaction; Thromboembolism; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function.
Topics: Adult; Alleles; Brachial Artery; Cholesterol; Cholesterol, HDL; Endothelium, Vascular; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Ultrasonography; Vasodilation | 2003 |
B vitamin status and inflammatory markers.
Topics: Arteriosclerosis; Biomarkers; C-Reactive Protein; Cell Adhesion Molecules; Cross-Sectional Studies; Dietary Supplements; E-Selectin; Fibrinogen; Folic Acid; Homocysteine; Humans; Inflammation; Leukocyte Count; Middle Aged; Pyridoxal Phosphate; Risk Factors; Vitamin B 6; Vitamin B Complex; von Willebrand Factor | 2003 |
Re: Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer.
Topics: Anticarcinogenic Agents; Austria; Biomarkers, Tumor; Breast Neoplasms; Female; Folic Acid; Homocysteine; Humans; Risk Assessment; Vitamin B 12; Vitamin B 6 | 2003 |
[Do folates and homocysteine have a causal relation with neural tube defects?].
Topics: Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy | 2003 |
Intimal hyperplasia following carotid endarterectomy in an insulin-resistant rat model.
Topics: Animals; Cystathionine gamma-Lyase; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Sucrose; Disease Models, Animal; Endarterectomy, Carotid; Folic Acid; Homocysteine; Hyperplasia; Insulin; Insulin Resistance; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley; Tunica Intima | 2003 |
Homocysteine plasma levels after suspension of vitamin treatment.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Clinical Protocols; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Vitamin B 12 | 2003 |
Treatment of hyperhomocysteinemia in pediatric heart transplant recipients.
Topics: Adolescent; Antioxidants; Biomarkers; Child; Child Welfare; Child, Preschool; Combined Modality Therapy; Creatinine; Female; Folic Acid; Follow-Up Studies; Heart Transplantation; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Infant Welfare; Male; Statistics as Topic; Treatment Outcome; Vitamin A; Vitamin B 12; Vitamin E | 2003 |
Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation.
Topics: Administration, Oral; Animals; Cholesterol; Cholesterol, HDL; Cyclic GMP; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Folic Acid; Hindlimb; Homocysteine; Hypercholesterolemia; Ischemia; Male; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peripheral Vascular Diseases; Rats; Rats, Sprague-Dawley; Risk Factors; Severity of Illness Index | 2003 |
Plasma thiols and their determinants in phenylketonuria.
Topics: Adolescent; Cross-Sectional Studies; Cysteine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Male; Methionine; Phenylalanine; Phenylketonurias; Sulfhydryl Compounds; Vitamin B 12 | 2003 |
Folate intake assessment: validation of a new approach.
Topics: Adult; Cross-Sectional Studies; Diet; Diet Records; Female; Folic Acid; Homocysteine; Humans; Interviews as Topic; Mental Recall; Middle Aged; Nutritional Status; Statistics, Nonparametric; Surveys and Questionnaires | 2003 |
[Lactation--a risk factor for elevated plasma homocysteine?].
Topics: Adult; Biomarkers; Breast Feeding; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lactation; Risk Factors | 2003 |
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenine; Case-Control Studies; Coronary Disease; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Guanine; Homocysteine; Humans; Middle Aged; Osmolar Concentration; Risk Factors; Vitamin B 12 | 2003 |
Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Case-Control Studies; Child; Down Syndrome; Female; Ferredoxin-NADP Reductase; Flavoproteins; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Sicily | 2003 |
Impact of subclinical hypothyroidism on serum total homocysteine concentrations, the prevalence of coronary heart disease (CHD), and CHD risk factors in the New Mexico Elder Health Survey.
Topics: Aged; Aged, 80 and over; Coronary Disease; Creatinine; Fasting; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Hypothyroidism; Male; New Mexico; Prevalence; Risk Factors; Vitamin B 12 | 2003 |
Plasma homocysteine concentration and blood pressure in young adult African Americans.
Topics: Adult; Age Factors; Biomarkers; Black or African American; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Diastole; Female; Folic Acid; Homocysteine; Humans; Hypertension; Insulin; Male; Risk Factors; Sex Factors; Smoking; Statistics as Topic; Systole; Triglycerides; Vitamin B 12 | 2003 |
Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation.
Topics: Cell Transformation, Viral; Cells, Cultured; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Lymphocytes; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Riboflavin; Tetrahydrofolates | 2003 |
Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Antioxidants; Carbon; Carcinogens; Colon; Cystathionine beta-Synthase; Deficiency Diseases; Diet; Dimethylhydrazines; Disease Susceptibility; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Interactions; Folic Acid; Glutathione; Homocysteine; Injections, Intraperitoneal; Liver; Male; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; Selenium | 2003 |
Creatine supplementation decreases homocysteine in an animal model of uremia.
Topics: Animals; Biometry; Creatine; Folic Acid; Homocysteine; Liver; Male; Nephrectomy; Osmolar Concentration; Rats; Rats, Wistar; Uremia; Vitamin B 12 | 2003 |
Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cells.
Topics: Cells, Cultured; Concanavalin A; Folic Acid; Homocysteine; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Methionine; Phytohemagglutinins; Pokeweed Mitogens; Statistics, Nonparametric | 2003 |
Reported symptoms and clinical findings in relation to serum cobalamin, folate, methylmalonic acid and total homocysteine among elderly Swedes: a population-based study.
Topics: Aged; Atrophy; Cohort Studies; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Male; Methylmalonic Acid; Mouth Diseases; Mouth Mucosa; Stomatitis; Tongue; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Enzymatic methylation of homocysteine by a synthetic tetrahydrofolate derivative.
Topics: Cysteine; Folic Acid; Homocysteine; Humans; Methylation; Tetrahydrofolates | 1961 |
EFFECT OF VITAMIN B12 ANALOGUES ON METHIONINE FORMATION FROM N5-METHYLTETRAHYDROFOLIC ACID.
Topics: Carbon Isotopes; Corrinoids; Escherichia coli; Folic Acid; Homocysteine; Methionine; Pharmacology; Proteins; Research; Sulfhydryl Compounds; Vitamin B 12 | 1964 |
OROTIC ACID AND METABOLISM OF ONE CARBON UNIT: CONVERSION OF FOLIC ACID TO CITROVORUM FACTOR AND METHIONINE SYNTHESIS IN CHICK LIVER.
Topics: Animals; Carbon; Chickens; Folic Acid; Homocysteine; Leuconostoc; Leucovorin; Liver; Metabolism; Methionine; Orotic Acid; Poultry; Proteins; Research; Serine; Vitamin B 12; Vitamin B 12 Deficiency | 1963 |
ORGAN AND INTRACELLULAR LOCATION OF THE METHIONINE METHYL GROUP SYNTHESIZING SYSTEM OF THE RAT.
Topics: Adenosine Triphosphate; Brain; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Folic Acid; Glucose; Homocysteine; Kidney; Leuconostoc; Liver; Magnesium; Methionine; Muscles; NAD; Pectoralis Muscles; Proteins; Pyridoxal Phosphate; Rats; Research; Serine; Spectrophotometry | 1964 |
THE ROLE OF VITAMIN B12 IN METHYL TRANSFER TO HOMOCYSTEINE.
Topics: Chromatography; Escherichia coli; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Magnesium Sulfate; Mercaptoethanol; Methionine; Nucleosides; Pharmacology; Proteins; Research; Spectrophotometry; Sulfhydryl Compounds; Vitamin B 12 | 1964 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. VII. ISOLATION OF A COBALAMIN-CONTAINING TRANSMETHYLASE (5-METHYLTETRAHYDRO-FOLATE-HOMOCYSTEINE) FROM MAMMALIAN LIVER.
Topics: Animals; Chromatography; Corrinoids; Flavin-Adenine Dinucleotide; Folic Acid; Glutamates; Homocysteine; Liver; Methionine; Methyltransferases; NAD; NADP; Protamines; Research; Swine; Transferases; Vitamin B 12 | 1964 |
THE ROLE OF VITAMIN B12 IN METHIONINE BIOSYNTHESIS IN AVIAN LIVER.
Topics: Amino Acids; Animals; Birds; Coenzymes; Corrinoids; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Folic Acid; Homocysteine; Liver; Methionine; Poultry; Research; Transferases; Vitamin B 12 | 1964 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. IX. TRANSMETHYLATION FROM S-ADENOSYLMETHIONINE AND 5-METHYLTETRAHYDROFOLATE TO 2-MERCAPTOETHANOL AND HOMOCYSTEINE.
Topics: Alkylation; Biological Assay; Carbon Isotopes; Folic Acid; Homocysteine; Kinetics; Lactobacillus; Mercaptoethanol; Methionine; Nucleosides; Research; S-Adenosylmethionine; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolates; Transferases | 1965 |
STUDIES ON METHIONINE BIOSYNTHESIS. EFFECT OF ALKYLCOBAMIDE DERIVATIVES ON THE FORMATION OF HOLOENZYME.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Corrinoids; Dinitrophenols; Enzyme Inhibitors; Escherichia coli; Folic Acid; Holoenzymes; Homocysteine; Light; Metabolism; Methionine; Research; Transferases; Vitamin B 12 | 1965 |
Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia.
Topics: Biomarkers; Case-Control Studies; Dementia; Folic Acid; Gastritis; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Risk Factors; Vitamin B 12 | 2003 |
Fish oil supplementation of rats during pregnancy reduces adult disease risks in their offspring.
Topics: Animals; Blood Glucose; Caseins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dietary Proteins; Dietary Supplements; Female; Fish Oils; Folic Acid; Health Promotion; Homocysteine; Insulin; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Risk Factors; Triglycerides; Vitamin B 12 | 2003 |
Neither folic nor folinic acid normalize homocysteine levels in hemodialysis patients.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Linear Models; Male; Middle Aged; Prospective Studies; Renal Dialysis; Statistics, Nonparametric; Vitamin B 6 | 2003 |
Hyperhomocysteinemia in patients with heart failure referred for cardiac transplantation: preliminary observations.
Topics: Biomarkers; Cardiomyopathies; Coronary Artery Disease; Creatinine; Female; Florida; Folic Acid; Heart Failure; Heart Transplantation; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Oxygen Consumption; Pulmonary Wedge Pressure; Retrospective Studies; Severity of Illness Index; Statistics as Topic; Stroke Volume; Treatment Outcome | 2003 |
Gonadotropin treatment increases homocysteine levels in idiopathic hypogonadotropic hypogonadism: an indirect effect mediated by changes in body composition.
Topics: Adult; Body Composition; Case-Control Studies; Creatinine; Folic Acid; Gonadotropins; Gonadotropins, Pituitary; Homocysteine; Humans; Hypogonadism; Male; Regression Analysis; Testosterone; Vitamin B 12 | 2003 |
The effects of hydrogen peroxide promoted by homocysteine and inherited catalase deficiency on human hypocatalasemic patients.
Topics: Acatalasia; Adult; Catalase; Erythrocytes; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Hydrogen Peroxide; Male; Middle Aged; Oxidants; Oxidation-Reduction; Oxidative Stress | 2003 |
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.
Topics: Adult; Carbon; Carbon Isotopes; Female; Folic Acid; Homocysteine; Humans; Leucine; Methionine; Methylation; Reference Values; Serine | 2004 |
The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease.
Topics: Adult; Aged; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Cysteine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Threonine; Vitamin B 12 | 2003 |
Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia.
Topics: Adult; Base Pairing; DNA Mutational Analysis; Erythrocytes; Female; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Assessment; Schizophrenia; Schizophrenic Psychology; Vitamin B 12; Vitamin B 6 | 2003 |
Lowering plasma homocysteine.
Topics: Arteriosclerosis; Cardiovascular Diseases; Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B 12 | 2003 |
Hyperhomocystinemia in children with inflammatory bowel disease.
Topics: Adolescent; Aging; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Male; Methylenetetrahydrofolate Reductase (NADPH2); Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Tetrahydrofolates; Thromboembolism; Vitamin B 12; von Willebrand Factor | 2003 |
Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts.
Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Homocysteine; Humans; Infant; Mothers; Pyridoxal Phosphate; Risk Factors; Vitamin B 12; Vitamin B 6 | 2003 |
Routine determination of serum methylmalonic acid and plasma total homocysteine in Norway.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Clinical Laboratory Techniques; Creatinine; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methylmalonic Acid; Middle Aged; Norway; Sex Factors; Vitamin B 12 | 2003 |
Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries.
Topics: Aged; Coronary Artery Disease; Coronary Restenosis; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Postoperative Complications; Prosthesis Implantation; Stents; Thrombosis; Treatment Outcome; Vitamin B 12 | 2003 |
Effect of homocysteine-lowering therapy on vascular endothelial function and exercise performance in coronary patients with hyperhomocysteinaemia.
Topics: Aged; Analysis of Variance; Blood Flow Velocity; Brachial Artery; Coronary Angiography; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Exercise Test; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Ultrasonography; Vasodilation; Vitamin B 12; Vitamin B 6 | 2003 |
Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells.
Topics: Biological Transport; Blotting, Western; Carrier Proteins; Cell Line; Culture Media; Dose-Response Relationship, Drug; Eye Proteins; Folic Acid; Gene Expression; Homocysteine; Humans; Membrane Proteins; Membrane Transport Proteins; Pigment Epithelium of Eye; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Time Factors | 2003 |
[Plasma homocysteine in human immunodeficiency virus infected patient].
Topics: Adult; Anti-HIV Agents; Arteriosclerosis; Biomarkers; Case-Control Studies; Female; Folic Acid; HIV Infections; Homocysteine; Humans; Hyperhomocysteinemia; Insulin Resistance; Male; P-Selectin; Risk Factors; Smoking; Vitamin B 12 | 2003 |
[Serum homocysteine in children and adolescents. Relation with family history of cardiovascular disease].
Topics: Adolescent; Cardiovascular Diseases; Child; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Lipoproteins; Male; Risk Factors; Vitamin B 12 | 2003 |
Cardiovascular risk of young growth-hormone-deficient adolescents. Differences in growth-hormone-treated and untreated patients.
Topics: Adolescent; Cardiovascular Diseases; Child; Cholesterol, HDL; Cholesterol, LDL; Dietary Fats; Eating; Fasting; Female; Fibrinogen; Folic Acid; Homocysteine; Hormone Replacement Therapy; Human Growth Hormone; Humans; Male; Plasminogen Activator Inhibitor 1; Postprandial Period; Risk Assessment; Time Factors; Triglycerides; Vitamin B 12 | 2003 |
Homocysteine level and other biochemical parameters in cardiovascular disease patients with diabetes mellitus.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Diabetic Angiopathies; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Risk Factors; Vitamin B 12 | 2003 |
[Serum homocysteine, vitamin B12 and folic acid concentrations in patients with alcoholic liver cirrhosis].
Topics: Female; Folic Acid; Homocysteine; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Vitamin B Complex | 2003 |
Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteine.
Topics: Aged; Case-Control Studies; Diet; Dietary Supplements; DNA Methylation; DNA Repair; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prostatic Neoplasms; Risk Factors; Vitamin B 12; Vitamin B 6 | 2003 |
Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C-->T polymorphism in young women.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Cytosine; Dose-Response Relationship, Drug; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Polymorphism, Genetic; Thymine | 2003 |
Nutrigenes, functional genomics and systems biology.
Topics: Animals; Biology; Folic Acid; Genes; Genomics; Homocysteine; Mice; Models, Biological; Nutritional Physiological Phenomena | 2003 |
Abdominal aortic aneurysm and its correlation to plasma homocysteine, and vitamins.
Topics: Aged; Aortic Aneurysm, Abdominal; Case-Control Studies; Folic Acid; Homocysteine; Humans; Middle Aged; Vitamin B 12 | 2004 |
Homocysteine and red blood cell glutathione as indices for middle-aged untreated essential hypertension patients.
Topics: Biomarkers; Blood Pressure; Blood Proteins; Body Mass Index; Case-Control Studies; Creatinine; Erythrocytes; Estonia; Folic Acid; Glutathione; Homocysteine; Humans; Hypertension; Male; Middle Aged; Oxidative Stress; Statistics as Topic; Systole | 2003 |
Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Diet, Vegetarian; Female; Folic Acid; Germany; Homocysteine; Humans; Kidney Diseases; Male; Methylmalonic Acid; Middle Aged; Risk; Syria; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Hyperhomocysteinemia and B-vitamin status after discontinuation of oral anticoagulation therapy in patients with a history of venous thromboembolism.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticoagulants; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Retrospective Studies; Substance Withdrawal Syndrome; Thromboembolism; Vitamin B 12; Warfarin | 2003 |
Homocysteine increases during endurance exercise.
Topics: Adult; Exercise; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Physical Endurance; Reference Values; Sports; Time Factors; Vitamin B 12 | 2003 |
Comparison of the influence of volume-oriented training and high-intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers.
Topics: Adolescent; Anthropometry; Exercise; Folic Acid; Heart Rate; Homocysteine; Humans; Methylmalonic Acid; Reference Values; Swimming; Time Factors; Vitamin B 12; Vitamin B 6 | 2003 |
Oxidative stress in kidney transplant patients.
Topics: Adult; Cadaver; Creatinine; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Hematocrit; Homocysteine; Humans; Kidney Transplantation; Living Donors; Male; Oxidative Stress; Reactive Oxygen Species; Reference Values; Regression Analysis; Retrospective Studies; Time Factors; Tissue Donors | 2003 |
[Effect of homocysteine concentration in follicular fluid on a degree of oocyte maturity].
Topics: Chorionic Gonadotropin; Female; Fertility Agents, Female; Fertilization in Vitro; Folic Acid; Follicular Fluid; Homocysteine; Humans; Nafarelin; Oocytes; Time Factors | 2003 |
Homocysteine levels are associated with the severity of peripheral arterial disease in Type 2 diabetic patients.
Topics: Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Peripheral Vascular Diseases; ROC Curve; Vitamin B 6 | 2003 |
Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
Topics: Absorptiometry, Photon; Bone Density; Bone Diseases, Metabolic; Feeding Behavior; Female; Folic Acid; Homocysteine; Humans; Linear Models; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal; Patient Selection; Postmenopause; Risk Factors; Vitamin B 12 | 2003 |
Effects of the interaction between the C677T 5,10-methylenetetrahydrofolate reductase polymorphism and serum B vitamins on homocysteine levels in pregnant women.
Topics: Adult; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Pregnancy; Radioimmunoassay; Riboflavin; Vitamin B 12; Vitamin B 6 | 2004 |
Plasma total homocysteine concentrations in adults with growth hormone (GH) deficiency: effects of GH replacement.
Topics: Adult; Creatinine; Female; Folic Acid; Homocysteine; Hormone Replacement Therapy; Human Growth Hormone; Humans; Immunoradiometric Assay; Insulin; Insulin-Like Growth Factor I; Linear Models; Longitudinal Studies; Male; Thyroxine; Vitamin B 12 | 2003 |
Folic acid rescues nitric oxide-induced neural tube closure defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Radioisotopes; Chick Embryo; Culture Techniques; Folic Acid; Hemoglobins; Homocysteine; Models, Biological; Neural Tube Defects; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Tetrahydrofolates; Time Factors | 2004 |
Metabolic markers of cobalamin deficiency and cognitive function in normal older adults.
Topics: Aged; Citric Acid; Cognition; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Methylmalonic Acid; Statistics, Nonparametric; Vitamin B 12 | 2004 |
Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke.
Topics: Acute Disease; Analysis of Variance; Dietary Supplements; Erythrocytes; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Stroke; Tetrahydrofolates; Vitamins | 2004 |
Evidence suggests diabetes outcomes linked to homocysteine.
Topics: Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B Complex | 2003 |
Vitamin B12 and folate deficiency in later life.
Topics: Age Factors; Aged; Aged, 80 and over; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Institutionalization; Prevalence; United Kingdom; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Cobalamin (vitamin B12) metabolism during pregnancy.
Topics: Adult; Anemia, Megaloblastic; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Vitamin B 12 | 2004 |
Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes.
Topics: Adult; Aged; Cell Death; Cell Division; Cell Nucleus; Cells, Cultured; Culture Media; Female; Folic Acid; Gene Rearrangement; Genomic Instability; Homocysteine; Homozygote; Humans; Lymphocytes; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Micronuclei, Chromosome-Defective; Micronucleus Tests; Middle Aged; Polymorphism, Genetic; Riboflavin | 2004 |
Vitamin B12 status in the elderly as judged by available biochemical markers.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Transcobalamins; Vitamin B 12; Vitamin B 6 | 2004 |
Plasma homocysteine levels in patients with early coronary artery stenosis and high risk factors.
Topics: Adult; Aged; Coronary Stenosis; Diabetes Complications; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Risk Factors; Smoking; Vitamin B 12 | 2003 |
[Hyperhomocysteinemia and deep-vein thrombosis].
Topics: Adult; Aged; Aged, 80 and over; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Restriction Fragment Length; Venous Thrombosis; Vitamin B 12 | 2003 |
Plasma homocysteine concentrations in adolescents with subclinical hypothyroidism.
Topics: Adolescent; Cholesterol; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypothyroidism; Isoantibodies; Kidney; Kidney Function Tests; Thyroiditis, Autoimmune; Thyrotropin; Thyroxine; Triiodothyronine; Vitamin B 12 | 2003 |
Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C --> T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels.
Topics: Adolescent; Adult; Case-Control Studies; Contraceptives, Oral; Female; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Risk Factors; Vitamin B 12 | 2004 |
Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.
Topics: 5' Untranslated Regions; Blotting, Western; Carrier Proteins; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Folate Receptors, GPI-Anchored; Folic Acid; HeLa Cells; Heterogeneous-Nuclear Ribonucleoproteins; Homocysteine; Humans; Protein Binding; Protein Biosynthesis; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA-Binding Proteins; RNA, Messenger; Time Factors; Transfection; Up-Regulation | 2004 |
Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vitamin B 12 | 2004 |
Hematological parameters and cobalamin status in infants born to smoking mothers.
Topics: Adult; Birth Weight; Erythrocyte Count; Female; Folic Acid; Gestational Age; Hemoglobins; Homocysteine; Humans; Infant; Infant, Newborn; Logistic Models; Maternal-Fetal Exchange; Methylmalonic Acid; Pregnancy; Smoking; Vitamin B 12 | 2004 |
Elevated levels of plasma homocysteine in hypertensive patients with diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Blood Pressure; Diabetes Mellitus; Diastole; Female; Folic Acid; Homocysteine; Humans; Hypertension; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Systole; Vitamin B 12 | 2003 |
Citrus pectin and oligofructose improve folate status and lower serum total homocysteine in rats.
Topics: Animals; Cecum; Cellulose; Citrus; Colon; Diet; Dietary Fiber; Erythrocytes; Fermentation; Folic Acid; Homocysteine; Liver; Male; Nutritional Status; Oligosaccharides; Pectins; Random Allocation; Rats; Rats, Sprague-Dawley; Tritium | 2003 |
Hyperhomocysteinemia and oxidative stress in hemodialysis: effects of supplementation with folic acid.
Topics: Ascorbic Acid; Dietary Supplements; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Lipid Peroxidation; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Proteins; Renal Dialysis; Vitamin B 12; Vitamin E | 2003 |
Associations between polymorphisms within the thymidylate synthase gene and spina bifida.
Topics: 3' Untranslated Regions; Case-Control Studies; DNA Primers; Exons; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Infant, Newborn; Models, Biological; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Spinal Dysraphism; Thymidylate Synthase | 2003 |
Effect of folic acid fortification of food on homocysteine-related mortality.
Topics: Aged; Coronary Disease; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Risk Factors | 2004 |
Prevalence of low vitamin B12 and high homocysteine in serum in an elderly male population: association with atrophic gastritis and Helicobacter pylori infection.
Topics: Aged; Folic Acid; Gastritis, Atrophic; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Male; Middle Aged; Pepsinogen A; Vitamin B 12 Deficiency | 2003 |
High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Folic Acid; Genotype; Homocysteine; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Low initial vitamin B12 levels in Helicobacter pylori--positive patients on chronic hemodialysis.
Topics: Anemia, Macrocytic; Female; Folic Acid; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prevalence; Renal Dialysis; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Plasma homocysteine after insulin infusion in type II diabetic patients with and without methionine intolerance.
Topics: Blood Glucose; Cysteine; Diabetes Mellitus, Type 2; DNA; Female; Folic Acid; Glucose Clamp Technique; Homocysteine; Humans; Hyperhomocysteinemia; Insulin; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymerase Chain Reaction; Vitamin B 12; Vitamin B 6 | 2004 |
The challenge of stroke prevention.
Topics: Antibodies, Antiphospholipid; Folic Acid; Homocysteine; Humans; Risk Factors; Risk Reduction Behavior; Stroke; Vitamin B 12; Vitamin B 6 | 2004 |
Laxative treatment elevates plasma homocysteine: a study on a population-based Swedish sample of old people.
Topics: Aged; Aged, 80 and over; Cathartics; Cohort Studies; Constipation; Drug Prescriptions; Female; Folic Acid; Geriatric Assessment; Homocysteine; Humans; Lactulose; Male; Sweden; Vitamin B 12 | 2004 |
[Study on the relationship of MTHFR polymorphisms with unexplained recurrent spontaneous abortion].
Topics: Abortion, Habitual; Adult; Alleles; China; DNA Mutational Analysis; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Vitamin B 12 | 2004 |
Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits.
Topics: Aging; Animals; Disease Models, Animal; Fatty Acids; Folic Acid; Glutathione; Homocysteine; Lipid Peroxidation; Liver; Metabolic Clearance Rate; Rabbits; Thiobarbituric Acid Reactive Substances | 2004 |
Dietary prevention of post-angioplasty restenosis. From illusion and disillusion to pragmatism.
Topics: Angioplasty, Balloon, Coronary; Coronary Restenosis; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Risk Factors; Vitamin B Complex | 2003 |
Diet score is associated with plasma homocysteine in a healthy institutionalised elderly population.
Topics: Aged; Aged, 80 and over; Cohort Studies; Cross-Sectional Studies; Diet; Female; Folic Acid; Homes for the Aged; Homocysteine; Humans; Male; Middle Aged; Nursing Homes; Prospective Studies; Riboflavin; Spain; Vitamin B 12 | 2003 |
Concentrations of B vitamins and homocysteine in children with sickle cell anemia.
Topics: Anemia, Sickle Cell; Black People; Case-Control Studies; Child; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 6; Vitamins | 2004 |
[Influence of biochemical and genetic factors on homocysteine concentrations].
Topics: Adolescent; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Vitamin B 12 | 2004 |
Effect of vitamin B12 on homocysteine plasma concentration in hemodialysis patients.
Topics: Aged; Folic Acid; Homocysteine; Humans; Middle Aged; Renal Dialysis; Uremia; Vitamin B 12 | 2004 |
Hyperhomocysteinaemia & folic acid supplementation in patients with high risk of coronary artery disease.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Coronary Artery Disease; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Male; Microscopy, Fluorescence; Middle Aged; Risk Factors; Time Factors; Vitamin B 12 | 2004 |
[Assessment of medical students' intake of antioxidants and vitamins essential for homocysteine metabolism].
Topics: Adult; Antioxidants; Ascorbic Acid; Diet; Diet Surveys; Feeding Behavior; Female; Folic Acid; Food Preferences; Health Behavior; Health Education; Homocysteine; Humans; Male; Nutrition Surveys; Poland; Students, Medical; Vitamin B 12; Vitamin B 6; Vitamin E; Vitamins | 2002 |
Serum total homocysteine levels, folate, and B-vitamins intake and coronary heart disease risk factors among tri-ethnic college students.
Topics: Adult; Black or African American; Coronary Disease; Female; Florida; Folic Acid; Hispanic or Latino; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Male; Risk Factors; Sex Factors; Smoking; Universities; Vitamin B 12; Vitamin B 6; White People | 2004 |
Eat right and exercise for lower homocysteine levels and less chance of heart disease.
Topics: Adult; Age Factors; Coronary Disease; Exercise; Feeding Behavior; Female; Florida; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Risk Factors; Smoking; Vitamin B 12; Vitamin B 6 | 2004 |
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia.
Topics: Animals; Ascorbic Acid; Blotting, Western; Diet; Folic Acid; Glutathione; Hepatocytes; Homeostasis; Homocysteine; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; tert-Butylhydroperoxide; Tissue Distribution | 2004 |
Perinatal outcome prediction by maternal homocysteine and uterine artery Doppler velocimetry.
Topics: Adult; Arteries; Blood Flow Velocity; Female; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Laser-Doppler Flowmetry; Predictive Value of Tests; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Sensitivity and Specificity; Ultrasonography; Uterus; Vitamin B 12 | 2004 |
Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation.
Topics: Adenine; Aniline Compounds; Animals; Calcium; Cells, Cultured; Chick Embryo; Cytosol; Dizocilpine Maleate; Folic Acid; Folic Acid Deficiency; Ganglia, Spinal; Homocysteine; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Neurons; Nimodipine; Oxidative Stress; Reactive Oxygen Species; Thapsigargin; Xanthenes | 2004 |
Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status.
Topics: Biomarkers; Bone and Bones; Bone Density; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Phenotype; Polymorphism, Genetic; Ultrasonography | 2004 |
Comparative analysis of serum homocysteine, folic acid and Vitamin B12 levels in patients with noise-induced hearing loss.
Topics: Adult; Audiometry, Pure-Tone; Case-Control Studies; Folic Acid; Hearing Loss, Noise-Induced; Homocysteine; Humans; Male; Surveys and Questionnaires; Vitamin B 12 | 2004 |
Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence.
Topics: Adenoma; Adult; Aged; Colorectal Neoplasms; Diet; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Neoplasm Recurrence, Local; Risk Factors; Surveys and Questionnaires | 2004 |
Hyperhomocysteinemia in patients with Behçet's disease: is it due to inflammation or therapy?
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Behcet Syndrome; C-Reactive Protein; Colchicine; Drug Therapy, Combination; Eye Diseases; Female; Folic Acid; Glucocorticoids; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Male; Thrombosis; Vitamin B 12 | 2005 |
Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population.
Topics: Case-Control Studies; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Neural Tube Defects; Polymorphism, Genetic; United Kingdom | 2004 |
Young stroke and basal plasma and post-methionine load homocysteine and cysteine levels 1 year after the acute event: do plasma folates make the difference?
Topics: Adult; Case-Control Studies; Cysteine; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methionine; Middle Aged; Stroke; Time Factors; Vitamin B 12 | 2004 |
Analysis of hippocampal atrophy in alcoholic patients by a Kohonen feature map.
Topics: Adult; Aged; Alcohol-Induced Disorders, Nervous System; Atrophy; Avitaminosis; Data Interpretation, Statistical; Ethanol; Female; Folic Acid; Hippocampus; Homocysteine; Humans; Linear Models; Male; Middle Aged; Neural Networks, Computer; Reference Values; Sex Factors; Vitamin B 12; Vitamin B 6 | 2004 |
Hyperproliferation of homocysteine-treated colon cancer cells is reversed by folate and 5-methyltetrahydrofolate.
Topics: Caco-2 Cells; Cell Cycle; Cell Death; Cell Division; Colonic Neoplasms; Flow Cytometry; Folic Acid; Hematinics; Homocysteine; Humans; In Vitro Techniques; Tetrahydrofolates; Time Factors | 2004 |
Effects of TCN2 776C>G on vitamin B, folate, and total homocysteine levels in kidney transplant patients.
Topics: Adult; Aged; Alleles; Cross-Sectional Studies; Female; Folic Acid; Gene Frequency; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Kidney Transplantation; Male; Middle Aged; Polymorphism, Single Nucleotide; Transcobalamins; Vitamin B 12 | 2004 |
Homocysteine and folic acid are inversely related in black women with preeclampsia.
Topics: Adolescent; Adult; Arteriosclerosis; Black People; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Maternal Age; Pennsylvania; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Risk Factors; Vitamin B 12; White People | 2004 |
[Relations of methionine synthase gene variation with congenital heart disease].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glutathione; Heart Defects, Congenital; Heart Septal Defects; Homocysteine; Humans; Infant; Male; Polymorphism, Genetic; Vitamin B 12 | 2004 |
Maternal metabolic phenotype and risk of Down syndrome: beyond genetics.
Topics: Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Vitamin B 12 Deficiency | 2004 |
Homocysteine in a multi-ethnic sample of school-age children.
Topics: Adolescent; Cardiovascular Diseases; Child; Diet; Ethnicity; Fasting; Female; Folic Acid; Hispanic or Latino; Homocysteine; Humans; Indians, North American; Male; Nutrition Policy; School Health Services; Vitamin B 12; Vitamin B 6; White People | 2004 |
Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats.
Topics: Age Factors; Aging; Animals; Blood Viscosity; Cardiovascular Diseases; Cholesterol; Folic Acid; Homocysteine; Lipoproteins; Male; Rats; Rats, Wistar; Risk Factors; Sleep Deprivation; Triglycerides; Vitamin B 12 | 2004 |
Serum levels of folate, vitamin B12 and homocysteine in complete hydatidiform mole.
Topics: Adult; Biomarkers; Case-Control Studies; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hydatidiform Mole; Luminescent Measurements; Pregnancy; Vitamin B 12 | 2004 |
Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients.
Topics: Adult; Analysis of Variance; Base Sequence; Cross-Sectional Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Expression; Graft Rejection; Graft Survival; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Molecular Sequence Data; Multivariate Analysis; Mutation; Polymerase Chain Reaction; Prognosis; Vitamin B 12 | 2004 |
Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease.
Topics: Aged; Biomarkers; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; DNA Primers; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Severity of Illness Index; Vitamin B 12 | 2004 |
The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Case-Control Studies; Cell Transformation, Neoplastic; Central Nervous System Neoplasms; DNA, Neoplasm; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Lymphoma; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic | 2004 |
Elevated plasma homocysteine levels in gestational diabetes mellitus.
Topics: Adult; Blood Glucose; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes, Gestational; Female; Folic Acid; Gestational Age; Glucose Tolerance Test; Homocysteine; Humans; Pregnancy; Prospective Studies; Triglycerides; Turkey; Vitamin B 12 | 2004 |
Homocysteine and cobalamin status in German vegans.
Topics: Adult; Aged; Aged, 80 and over; Body Mass Index; Cross-Sectional Studies; Diet, Vegetarian; Female; Folic Acid; Germany; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha.
Topics: Adult; Aged; Antineoplastic Agents; Female; Folic Acid; Homocysteine; Humans; Interferon alpha-2; Interferon-alpha; Kynurenine; Macrophage Activation; Male; Melanoma; Middle Aged; Neopterin; Predictive Value of Tests; Recombinant Proteins; Tryptophan; Vitamin B 12 | 2004 |
Homocysteine and progression of coronary artery disease.
Topics: Adult; Blood Glucose; Coronary Artery Disease; Disease Progression; Folic Acid; Homocysteine; Humans; Hypertension; Lipids; Male; Middle Aged; Myocardial Infarction; Obesity; Research Design; Risk Factors; Smoking; Vitamin B 12 | 2004 |
Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight.
Topics: Adolescent; Adult; Birth Weight; Dietary Supplements; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Labor, Obstetric; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters | 2004 |
Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid.
Topics: Amino Acids; Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child, Preschool; Epinephrine; Folic Acid; Homocysteine; Humans; Injections, Intraventricular; Male; Methotrexate; Neoplasm Staging | 2004 |
Fibrate treatment and prevalence risk of mild hyperhomocysteinaemia in clinical coronary heart disease patients.
Topics: Case-Control Studies; Coronary Disease; Creatinine; Female; Folic Acid; Genotype; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Hypolipidemic Agents; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Prevalence; Retrospective Studies; Vitamin B 12 | 2004 |
Diet, serum homocysteine levels and ischaemic heart disease in a Mediterranean population.
Topics: Adult; Aged; Case-Control Studies; Cholesterol; Creatinine; Diet; Female; Folic Acid; Greece; Homocysteine; Humans; Male; Middle Aged; Myocardial Ischemia; Vitamin B 12 | 2004 |
Plasma homocysteine levels and risk of Alzheimer disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Cohort Studies; Comorbidity; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Cysteine; Dementia; Diabetes Mellitus; Ethnicity; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Memory; Neuropsychological Tests; New York City; Prevalence; Risk Factors; Sampling Studies; Stroke; Vitamin B 12; Vitamin B 6 | 2004 |
A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida.
Topics: ATP-Binding Cassette Transporters; Folic Acid; Genetic Variation; Homocysteine; Humans; Likelihood Functions; Linear Models; Multidrug Resistance-Associated Protein 2; Neural Tube Defects; Pedigree; Polymorphism, Genetic; Promoter Regions, Genetic; Retrospective Studies; Risk Factors; Spinal Dysraphism | 2004 |
[Homocysteine-induced apoptosis of endothelial cell and its antagonism by folic acid--the roles of caspase3, c-IAP1 and c-IAP2].
Topics: Apoptosis; Caspase 3; Caspases; Cell Separation; Cells, Cultured; Endothelial Cells; Folic Acid; Homocysteine; Humans; Inhibitor of Apoptosis Proteins; Proteins; Ubiquitin-Protein Ligases; Umbilical Veins | 2004 |
Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cognition Disorders; Cross-Sectional Studies; Dementia, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Odds Ratio; Risk Factors; Switzerland; Vitamin B 12 | 2004 |
Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children.
Topics: Brazil; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors; Vitamin B 12 | 2004 |
Serum selenium is associated with plasma homocysteine concentrations in elderly humans.
Topics: Aged; Aged, 80 and over; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Energy Intake; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Selenium; Vitamin B 12 | 2004 |
Relationships of nutrient intake and lifestyle-related factors to serum folate and plasma homocysteine concentrations in 30-69 year-old Japanese.
Topics: Adult; Aged; Alcohol Drinking; Ascorbic Acid; Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Japan; Life Style; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Physiological Phenomena; Polymorphism, Genetic; Sex Characteristics; Smoking; Vitamin B Complex | 2004 |
Folic acid-based multivitamin therapy to prevent stroke: the jury is still out.
Topics: Clinical Trials as Topic; Dietary Supplements; Folic Acid; Homocysteine; Humans; Risk; Stroke | 2004 |
Plasma trace elements, vitamin B12, folate, and homocysteine levels in cirrhotic patients compared to healthy controls.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Health; Homocysteine; Humans; Liver Cirrhosis; Male; Middle Aged; Trace Elements; Vitamin B 12 | 2004 |
Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis.
Topics: Adolescent; Arteriosclerosis; Body Mass Index; C-Peptide; C-Reactive Protein; Carotid Artery, Common; Child; Diabetes Mellitus, Type 1; Female; Folic Acid; Homocysteine; Humans; Inflammation; Leptin; Male; Obesity; Receptors, Interleukin-2; Tunica Intima; Vitamin B 12 | 2004 |
Destructive, granulating lesion in the temporal bone after elevated plasma homocysteine.
Topics: Adult; Ear, Middle; Facial Paralysis; Folic Acid; Folic Acid Deficiency; Granulation Tissue; Hearing Loss, Sudden; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Temporal Bone; Thromboembolism; Tomography, X-Ray Computed; Vertigo | 2004 |
Folate and homocysteine levels in pregnancy.
Topics: Adult; Birth Intervals; Female; Folic Acid; Homocysteine; Humans; Pregnancy | 2004 |
Longitudinal change in plasma total homocysteine during pregnancy and postpartum in Brazilian women and its relation with folate status and other factors.
Topics: Brazil; Chromatography, High Pressure Liquid; Diet; Dietary Supplements; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Iron; Longitudinal Studies; Nutritional Status; Postpartum Period; Pregnancy; Socioeconomic Factors; Transferrin; Vitamin B 12 | 2004 |
Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Coffee; Female; Folic Acid; Germany; Homocysteine; Humans; Life Style; Linear Models; Longitudinal Studies; Male; Methionine; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Sex Characteristics; Smoking; Tea; Vitamin B 12 | 2004 |
Metabolic effects and the methylenetetrahydrofolate reductase (MTHFR) polymorphism associated with neural tube defects in southern Brazil.
Topics: Adolescent; Adult; Brazil; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Vitamin B 12 | 2004 |
Low serum folate levels: a risk factor for sudden sensorineural hearing loss?
Topics: Adolescent; Adult; Aged; Case-Control Studies; Cochlea; Female; Folic Acid; Folic Acid Deficiency; Hearing Loss, Sensorineural; Hearing Loss, Sudden; Homocysteine; Humans; Ischemia; Male; Middle Aged; Risk Factors | 2004 |
Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Topics: Coronary Disease; Finland; Folic Acid; Homocysteine; Humans; Incidence; Lipids; Male; Middle Aged; Prospective Studies; Risk Factors | 2004 |
Homocysteine and folate in pregnancy.
Topics: Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Prenatal Diagnosis; Reference Values | 2004 |
Homocysteine levels in women with antiphospholipid syndrome and normal fertile controls.
Topics: Adult; Antiphospholipid Syndrome; Chromatography, High Pressure Liquid; Female; Fertility; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Pregnancy; Pregnancy Outcome; Vitamin B 6 | 2004 |
Folate intake and risk of Parkinson's disease.
Topics: Adult; Cohort Studies; Diet; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Parkinson Disease; Prospective Studies; Reference Values; Risk Factors; United States; Vitamin B 12; Vitamin B 6 | 2004 |
Effect of folic acid on homocysteine-induced trophoblast apoptosis.
Topics: Apoptosis; Cells, Cultured; Chorionic Gonadotropin; DNA Fragmentation; Female; Folic Acid; Homocysteine; Humans; In Situ Nick-End Labeling; Placenta; Trophoblasts | 2004 |
Hyperhomocysteinemia in patients with Cushing's syndrome.
Topics: Adult; Aged; Case-Control Studies; Circadian Rhythm; Cushing Syndrome; Cysteine; DNA; Female; Folic Acid; Homocysteine; Humans; Hydrocortisone; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osmolar Concentration; Polymorphism, Genetic; Threonine | 2004 |
Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida.
Topics: Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Pregnancy; Risk Assessment; Risk Factors; Spinal Dysraphism; Vitamin B 12; Vitamin B 6 | 2004 |
The administration of a multivitamin/mineral fortified dairy product improves folate status and reduces plasma homocysteine concentration in women of reproductive age.
Topics: Adult; Dairy Products; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Minerals; Patient Compliance; Vitamin B 12; Vitamins | 2004 |
Oxidative stress in mothers who have conceived fetus with neural tube defects: the role of aminothiols and selenium.
Topics: Adult; Case-Control Studies; Cysteine; Dipeptides; Female; Folic Acid; Glutathione; Homocysteine; Humans; Infant, Newborn; Methionine; Mothers; Neural Tube Defects; Oxidation-Reduction; Oxidative Stress; Selenium; Sulfhydryl Compounds | 2004 |
Increasing production of homocysteine and neopterin and degradation of tryptophan with older age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Dioxygenases; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Macrophages; Male; Middle Aged; Neopterin; T-Lymphocytes; Time Factors; Tryptophan; Vitamin B 12 | 2004 |
Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan.
Topics: Adult; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Japan; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Vitamin B 12; Vitamin B 6 | 2004 |
Screening for serum total homocysteine in newborn children.
Topics: Blood Specimen Collection; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neonatal Screening; Polymorphism, Genetic; Reference Values; Serum; Sex Factors; Time Factors; Vitamin B 12 Deficiency | 2004 |
Effect of long-term, high-copper intake on the concentrations of plasma homocysteine and B vitamins in young men.
Topics: Adult; Chromatography, High Pressure Liquid; Copper; Dietary Supplements; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxal Phosphate; Reference Values; Time; Vitamin B Complex | 2004 |
Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Arabidopsis; Binding Sites; Cations; Crystallography, X-Ray; Cysteine; Escherichia coli; Folic Acid; Fourier Analysis; Histidine; Homocysteine; Methionine; Methyltransferases; Models, Molecular; Plasmids; Protein Conformation; Protein Structure, Tertiary; Sulfur; Tetrahydrofolates; Vitamin B 12; Zinc | 2004 |
Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C667T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study.
Topics: Aged; Analysis of Variance; Bone Density; Confidence Intervals; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Iran; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osteoporosis, Postmenopausal; Polymorphism, Genetic; Regression Analysis; Statistics, Nonparametric | 2004 |
Folate, homocysteine, and negative symptoms in schizophrenia.
Topics: Adult; Ambulatory Care; Basal Ganglia Diseases; Diet; Female; Folic Acid; Glutamate Carboxypeptidase II; Homocysteine; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Smoking; Vitamin B 12 | 2004 |
Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Colorectal Neoplasms; DNA Damage; DNA Methylation; Erythrocytes; Female; Folic Acid; Genetic Carrier Screening; Genetic Variation; Genotype; Homocysteine; Homozygote; Humans; Isoenzymes; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk; Scotland; Tetrahydrofolates; Uracil; Vitamin B 12 | 2004 |
Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures.
Topics: Adult; Alkanes; Benzene Derivatives; Case-Control Studies; Chloroform; Dietary Supplements; Dose-Response Relationship, Drug; Environmental Exposure; Female; Folic Acid; Hematologic Tests; Hemoglobins; Homocysteine; Humans; Hydrocarbons; Middle Aged; Multiple Chemical Sensitivity; Vitamin B 12; Vitamin B 6; Vitamins | 2004 |
Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women.
Topics: Adult; Cytosine; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Leukocytes; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2004 |
[Relationship of plasma homocysteine and folic acid levels and 5,10-methylenetetrahydrofolate reductase gene mutation with venous thromboembolism].
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Mutation; Venous Thrombosis | 2004 |
Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2004 |
Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Diet; Drug Synergism; Female; Folic Acid; Homes for the Aged; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nutritional Status; Risk Factors; Vitamin B 12; Vitamin B Complex | 2004 |
Folate therapy and in-stent restenosis.
Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Coronary Restenosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Stents; Vitamin B 6; Vitamin B Complex | 2004 |
Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification.
Topics: Acculturation; Aged; Aging; California; Cross-Sectional Studies; Depression; Diet; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Hispanic or Latino; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Sex Factors; Vitamin B 12 | 2004 |
Phenotypic expression of the methylenetetrahydrofolate reductase 677C-->T polymorphism and flavin cofactor availability in thyroid dysfunction.
Topics: Adult; Antithyroid Agents; Female; Folic Acid; Gene Expression Regulation; Genotype; Homocysteine; Humans; Hyperthyroidism; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Phenotype; Polymorphism, Genetic; Regression Analysis; Riboflavin | 2004 |
Coronary artery bypass grafting surgery is associated with a marked reduction in serum homocysteine and folate levels in the early postoperative period.
Topics: Aged; Blood Proteins; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Postoperative Complications; Postoperative Period | 2004 |
[Determinants of plasma homocysteine concentration].
Topics: Erythrocytes; Folic Acid; Homocysteine; Humans | 2004 |
Plasma folate as marker of folate status in epidemiological studies: the European Investigation into Cancer and Nutrition (EPIC)-Potsdam study.
Topics: Adult; Age Factors; Biomarkers; Body Mass Index; Cross-Sectional Studies; Diet; Dietary Supplements; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Life Style; Male; Middle Aged; Polymorphism, Genetic; Pyridoxal Phosphate; Pyridoxine; Vitamin B 12 | 2004 |
Negative association between circulating total homocysteine and proinflammatory chemokines MCP-1 and RANTES in prepubertal lean, but not in obese, children.
Topics: Arteriosclerosis; Blood Glucose; Body Mass Index; Body Weight; Chemokine CCL2; Chemokine CCL5; Chemotaxis, Leukocyte; Child; Cholesterol, HDL; Data Interpretation, Statistical; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Insulin; Male; Obesity; Puberty; Sex; Thinness; Triglycerides; Vitamin B 12 | 2004 |
Folate intake estimated with an updated database and its association to blood folate and homocysteine in Korean college students.
Topics: Adolescent; Adult; alpha-Amylases; Cooking; Databases, Factual; Erythrocytes; Female; Folic Acid; Food Analysis; Food Handling; Health Surveys; Homocysteine; Humans; Korea; Male; Mental Recall; Nutrition Surveys; Peptide Hydrolases; Sex Factors | 2005 |
A population-based intervention study on elevated serum levels of methylmalonic acid and total homocysteine in elderly people: results after 36 months of follow-up.
Topics: Aged; Cohort Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Male; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Case-Control Studies; Dementia, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neurons; Nutritional Status; Oxidative Stress; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Homocysteine effect on protein degradation rates.
Topics: Aged; Aged, 80 and over; Animals; Female; Folic Acid; Homocysteine; Humans; Male; Neutrophils; Proteins; Rats; Vitamin B 12; Vitamin B 6 | 2004 |
Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study.
Topics: Adult; Aged; Bone Neoplasms; Case-Control Studies; Folic Acid; Homocysteine; Humans; Lymphatic Metastasis; Male; Middle Aged; Prospective Studies; Prostatic Neoplasms; Risk Factors; Sweden; Vitamin B 12 | 2005 |
Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677C->T variant.
Topics: Adult; Dietary Supplements; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vitamin B 12 | 2004 |
Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a cross-sectional study in patients with type 2 diabetes mellitus.
Topics: Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Vitamin B 12 | 2004 |
The effect of low doses of betaine on plasma homocysteine in healthy volunteers.
Topics: Adult; Betaine; Dose-Response Relationship, Drug; Drug Combinations; Female; Folic Acid; Homocysteine; Humans; Lipotropic Agents; Male; Middle Aged | 2004 |
Folate intake, serum folate, serum total homocysteine levels and methylenetetrahydrofolate reductase C677T polymorphism in young Japanese women.
Topics: Adult; Chromatography, High Pressure Liquid; Diet Records; Female; Folic Acid; Genotype; Homocysteine; Humans; Japan; Luminescent Measurements; Methylenetetrahydrofolate Reductase (NADPH2); Nutrition Policy; Nutritional Requirements; Nutritional Status; Polymorphism, Genetic; United States | 2004 |
Response of homocysteine, cystathionine, and methylmalonic acid to vitamin treatment in dialysis patients.
Topics: Aged; Aged, 80 and over; Cystathionine; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylmalonic Acid; Middle Aged; Renal Dialysis; Vitamin B 12; Vitamin B 6 | 2005 |
Changes of homocysteine levels and arterial endothelial function in patients with high risk of coronary artery disease after 6-month folic acid supplementation.
Topics: Aged; Arteries; Chromatography, High Pressure Liquid; Coronary Artery Disease; Dietary Supplements; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Time; Treatment Outcome; Vitamin B 12 | 2004 |
Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Female; Folic Acid; Homocysteine; Humans; Male; Pulse | 2004 |
Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors.
Topics: C-Reactive Protein; Cholesterol; Cholesterol, HDL; Coronary Disease; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Middle Aged; Receptors, Tumor Necrosis Factor; Risk Factors; Thiamine | 2004 |
Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arabs; Case-Control Studies; Confidence Intervals; Female; Folic Acid; Homocysteine; Humans; Israel; Male; Odds Ratio; Vitamin B 12 | 2004 |
Betaine and folate status as cooperative determinants of plasma homocysteine in humans.
Topics: Adult; Aged; Betaine; Choline; Creatinine; Dose-Response Relationship, Drug; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Middle Aged; Sarcosine; Vitamin B 12; Vitamin B 6 | 2005 |
Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency.
Topics: Cystathionine; Cystatin C; Cystatins; Female; Folic Acid; HELLP Syndrome; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Function Tests; Methylmalonic Acid; Oxidative Stress; Placental Insufficiency; Pre-Eclampsia; Pregnancy; Severity of Illness Index; Uric Acid; Vitamin B 12; Vitamin B 6 | 2004 |
A case of Buerger's disease associated with MTHFR C677T mutation homozygosity: a possible therapeutic support.
Topics: Adult; Carbon-Nitrogen Ligases; Folic Acid; Homocysteine; Humans; Male; Mutation; Thromboangiitis Obliterans; Treatment Outcome | 2004 |
Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.
Topics: Arthritis, Rheumatoid; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methotrexate; Probability; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Vitamin B 12 | 2004 |
The risk of folate and vitamin B(12) deficiencies associated with hyperhomocysteinemia among pregnant women.
Topics: Adolescent; Adult; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Korea; Pregnancy; Pregnancy Complications; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Short-term effect of folic acid supplementation in renal transplant recipients and chronic kidney disease patients with comparable renal function impairment.
Topics: Adult; Chronic Disease; Female; Folic Acid; Homocysteine; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Male; Middle Aged | 2004 |
Frequent consumption of milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables and intakes of dietary folate and riboflavin but not vitamins B-12 and B-6 are inversely associated with serum total homocysteine concentrations in the US po
Topics: Adult; Animals; Brassicaceae; Capsicum; Cross-Sectional Studies; Dairy Products; Edible Grain; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Milk; Multivariate Analysis; Nutrition Surveys; Riboflavin; Surveys and Questionnaires; United States; Vegetables; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Yogurt | 2004 |
Homocysteine concentrations in adults with trisomy 21: effect of B vitamins and genetic polymorphisms.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Administration, Oral; Adolescent; Adult; Case-Control Studies; Cystathionine beta-Synthase; Dietary Supplements; Down Syndrome; Drug Synergism; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Reduced Folate Carrier Protein; Vitamin B 12; Vitamin B 6 | 2004 |
Association between depressive symptoms and serum concentrations of homocysteine in men: a population study.
Topics: Cohort Studies; Cross-Sectional Studies; Depression; Finland; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Odds Ratio; Psychometrics; Surveys and Questionnaires; Vitamin B 12 | 2004 |
Serum levels of folate, homocysteine, and vitamin B12 in head and neck squamous cell carcinoma and in laryngeal leukoplakia.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Female; Folic Acid; Head and Neck Neoplasms; Homocysteine; Humans; Laryngeal Neoplasms; Leukoplakia; Male; Middle Aged; Prognosis; Reference Values; Risk Assessment; Sensitivity and Specificity; Vitamin B 12 | 2005 |
Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 2005 |
Effect of folic acid on methionine and homocysteine metabolism in end-stage renal disease.
Topics: Administration, Oral; Adult; Aged; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kinetics; Male; Methionine; Methylation; Middle Aged; Renal Dialysis | 2005 |
Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation.
Topics: Adolescent; Adult; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Pregnancy; Pregnancy Trimester, Third | 2005 |
Folate deficiency increases postischemic brain injury.
Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Colorimetry; DNA Damage; Folic Acid; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Infarction, Middle Cerebral Artery; Mice; Mice, Transgenic; Oxygen; Reperfusion; Reperfusion Injury; Risk; Stroke; Time Factors; Uracil-DNA Glycosidase | 2005 |
Plasma folate and homocysteine levels may be related to interictal "schizophrenia-like" psychosis in patients with epilepsy.
Topics: Adult; Electroencephalography; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Schizophrenic Psychology; Vitamin B 12 | 2005 |
Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Methotrexate; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B Complex | 2006 |
Homocysteine, antiphospholipid antibodies and risk of thrombosis in patients with systemic lupus erythematosus.
Topics: Adult; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Cholesterol; Creatinine; Female; Folic Acid; Homocysteine; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Risk Factors; Thrombosis; Vitamin B 12 | 2004 |
Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects.
Topics: Adult; Amino Acids; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Methylation; Middle Aged; Vitamins | 2005 |
Beneficial effects of Bifidobacteria in a gastroresistant seamless capsule on hyperhomocysteinemia in hemodialysis patients.
Topics: Bifidobacterium; Capsules; Colony Count, Microbial; Escherichia coli; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Indican; Intestines; Probiotics; Renal Dialysis; Uremia | 2005 |
Effects of dietary supplements of folic acid and rumen-protected methionine on lactational performance and folate metabolism of dairy cows.
Topics: Animals; Cattle; Cysteine; Diet; Dietary Supplements; Female; Folic Acid; Hemoglobins; Homocysteine; Kinetics; Lactation; Methionine; Milk; Rumen; Vitamin B 12 | 2005 |
Effects of intramuscular injections of vitamin B12 on lactation performance of dairy cows fed dietary supplements of folic acid and rumen-protected methionine.
Topics: Animals; Cattle; Cysteine; Diet; Dietary Supplements; Eating; Female; Folic Acid; Homocysteine; Injections, Intramuscular; Lactation; Methionine; Methylmalonic Acid; Milk; Parity; Rumen; Vitamin B 12 | 2005 |
Serum lipid profiles and homocysteine levels in adults with stroke or myocardial infarction in the town of Gombe in northern Nigeria.
Topics: Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Female; Folic Acid; Homocysteine; Humans; Hypertension; Lipids; Male; Middle Aged; Myocardial Infarction; Nigeria; Risk Factors; Stroke; Triglycerides; Vitamin B 12 | 2004 |
Risk factors for cardiovascular disease and diet of urban and rural dwellers in northern Nigeria.
Topics: Adult; Aged; Cardiovascular Diseases; Diet; Female; Folic Acid; Homocysteine; Humans; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Nigeria; Risk Factors; Rural Population; Triglycerides; Urban Population; Vitamin B 12 | 2004 |
Homocysteine and its nutritional determinants in two ethnic groups of Slovakia.
Topics: Adult; Biomarkers; Case-Control Studies; Feeding Behavior; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Middle Aged; Nutrition Surveys; Slovakia; Vitamin B 12; Vitamin B 6 | 2004 |
Distribution of 5,10-methylenetetrahydrofolate reductase (C667T) polymorphism and its association with red blood cell 5-methyltetrahydrofolate in the healthy Iranians.
Topics: Analysis of Variance; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Iran; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Requirements; Polymorphism, Genetic; Tetrahydrofolates; Vitamin B 12 | 2005 |
A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations.
Topics: 3' Untranslated Regions; Adult; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Polymorphism, Genetic; Smoking; Thymidylate Synthase | 2005 |
Stroke and recurrent pregnancy loss due to hyperhomocysteinaemia.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Abortion, Habitual; Brain; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Infarction, Middle Cerebral Artery; Middle Aged; Mutation; Platelet Aggregation Inhibitors; Pregnancy; Stroke; Treatment Outcome; Vitamin B 12 | 2005 |
Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging.
Topics: Aged; Aging; Alzheimer Disease; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Longitudinal Studies; Male; Risk Factors; Vitamin B 12; Vitamin B 6 | 2005 |
Plasma concentration of folate as a biomarker for the intake of fruit and vegetables: the Hordaland Homocysteine Study.
Topics: Aged; Analysis of Variance; Animals; Biomarkers; Bread; Cohort Studies; Diet Surveys; Dietary Supplements; Female; Folic Acid; Fruit; Homocysteine; Humans; Male; Middle Aged; Milk; Nutrition Assessment; Surveys and Questionnaires; Vegetables | 2005 |
Cobalamin deficiency in elderly patients.
Topics: Aged; Algorithms; Canada; Folic Acid; Food, Fortified; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Substitution; Betaine; Brain; Cell Line, Transformed; Codon, Nonsense; DNA Mutational Analysis; Ferredoxin-NADP Reductase; Fibroblasts; Folic Acid; Genes, Synthetic; Genetic Complementation Test; Genetic Therapy; Haplotypes; Homocysteine; Homocystinuria; Humans; Hydroxocobalamin; Mutation, Missense; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Recombinant Fusion Proteins; Sequence Deletion; Transfection; White People | 2005 |
[Study of serum Hcy and polymorphisms of Hcy metabolic enzymes in 192 families affected by congenital heart disease].
Topics: Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Vitamin B 12 | 2005 |
Serum folate and homocysteine levels in obese females with non-alcoholic fatty liver.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Bariatrics; Body Mass Index; Case-Control Studies; Fatty Liver; Female; Folic Acid; Homocysteine; Humans; Liver Function Tests; Obesity, Morbid; Vitamin B 12 | 2005 |
Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alcohol Drinking; Colon; Colonoscopy; Cystathionine beta-Synthase; DNA; DNA Methylation; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reference Values | 2005 |
Plasma homocysteine concentrations in Greek children are influenced by an interaction between the methylenetetrahydrofolate reductase C677T genotype and folate status.
Topics: Biomarkers; Child; Coronary Disease; Female; Folic Acid; Genotype; Greece; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors | 2005 |
Folic acid supplementation can reduce the endothelial damage in rat brain microvasculature due to hyperhomocysteinemia.
Topics: Animals; Cerebrovascular Circulation; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Energy Intake; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Reference Values; Thiobarbituric Acid Reactive Substances; Vitamin B 12; Weight Gain | 2005 |
Homocysteine and fracture prevention.
Topics: Dietary Supplements; Folic Acid; Hip Fractures; Homocysteine; Humans; Risk Factors; Stroke; Vitamin B 12 | 2005 |
Low erythrocyte folate, but not plasma vitamin B-12 or homocysteine,is associated with dementia in elderly Latinos.
Topics: Aged; Aged, 80 and over; California; Cohort Studies; Dementia; Erythrocytes; Female; Folic Acid; Hispanic or Latino; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Vitamin B 12 | 2005 |
Elevation of plasma homocysteine in natural menopause can not be explained by a lack of vitamin coenzyme availability: relevance to the risk of cardiovascular disease.
Topics: Adult; Cardiovascular Diseases; Coenzymes; Diet; Estrogens; Female; Folic Acid; Homocysteine; Humans; Menopause; Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 6 | 2005 |
Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes.
Topics: Aged; Cystathionine; Cysteine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Male; Methionine; Methylmalonic Acid; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcobalamins; Vitamin B 12; Vitamin B 6 | 2005 |
Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Arteriosclerosis; Biomarkers; Carotid Artery Diseases; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Tunica Intima; Vascular Resistance | 2005 |
Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Chemokine CCL2; Colitis, Ulcerative; Crohn Disease; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Folic Acid; Homocysteine; Humans; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Leukocyte Adherence Inhibition Test; Male; Microcirculation; Middle Aged; Reference Values; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
Plasma vitamin B12, folate and homocysteine levels in gastrectomized men.
Topics: Case-Control Studies; Folic Acid; Gastrectomy; Homocysteine; Humans; Hyperhomocysteinemia; Japan; Male; Middle Aged; Peptic Ulcer; Risk Factors; Stomach Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Methimazole-induced hypothyroidism paradoxically decreases homocysteine.
Topics: Adolescent; Adult; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Hypothyroidism; Lipids; Logistic Models; Male; Methimazole; Methionine; Plasminogen Activator Inhibitor 1; Thyrotropin; Vitamin B 12; Vitamin B 6 | 2005 |
Hyperhomocysteinemia in L-dopa treated Parkinson's disease patients: effect of cobalamin and folate administration.
Topics: Aged; Antiparkinson Agents; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Middle Aged; Parkinson Disease; Vitamin B 12 | 2005 |
Investigation of systemic folate status, impact of alcohol intake and levels of DNA damage in mononuclear cells of breast cancer patients.
Topics: Alcohol Drinking; Breast Diseases; Breast Neoplasms; Comet Assay; Cross-Sectional Studies; DNA Damage; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leukocytes, Mononuclear; Middle Aged | 2005 |
Nutritional and life style determinants of plasma homocysteine in schizophrenia patients.
Topics: Adolescent; Adult; Blood Chemical Analysis; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Middle Aged; Nutritional Status; Schizophrenia; Vitamin B 12 | 2005 |
The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes.
Topics: Computers; DNA; Epidemiologic Studies; Folic Acid; Genotype; Homocysteine; Humans; Italy; Lymphocytes; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic | 2005 |
Impact of voluntary folate fortification on plasma homocysteine and serum folate in Australia from 1995 to 2001: a population based cohort study.
Topics: Adult; Aged; Cohort Studies; Dietary Supplements; Female; Folic Acid; Food, Fortified; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Plasma; Serum; Sex Characteristics; Western Australia | 2005 |
Plasma homocysteine concentration and its relation to symptoms of vascular disease in psychogeriatric patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Creatinine; Cystatin C; Cystatins; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Protein S; Vascular Diseases; Vitamin B 12 | 2005 |
Homocysteine and related genetic polymorphisms in Down's syndrome IQ.
Topics: Alleles; Alzheimer Disease; Apolipoproteins E; Diagnostic and Statistical Manual of Mental Disorders; Down Syndrome; Folic Acid; Homocysteine; Humans; Intelligence; Karyotyping; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Transcobalamins; Vitamin B 12 | 2005 |
Associations between MTHFR 1793G>A and plasma total homocysteine, folate, and vitamin B in kidney transplant recipients.
Topics: Adult; Aged; Alleles; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Kidney Diseases; Kidney Transplantation; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Treatment Outcome; Vitamin B 12 | 2005 |
[A clinical study of hyperhomocysteinemia in rheumatological diseases].
Topics: Adolescent; Adult; Child; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Rheumatic Diseases; Vitamin B 12 | 2005 |
Homocysteine, renal disease and cardiovascular disease in a remote Australian Aboriginal community.
Topics: Adult; Albuminuria; Arteriosclerosis; Australia; Cardiovascular Diseases; Cross-Sectional Studies; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Kidney Diseases; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Native Hawaiian or Other Pacific Islander; Polymorphism, Genetic; Regression Analysis; Rural Population; Vitamin B 12 | 2005 |
[Homocysteine and low dietary intake: two complementary forms of impairment (correction of improvement)].
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Thromboembolism; Vitamin B 12; Vitamin B 6 | 2005 |
Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment.
Topics: Adult; Anticoagulants; Betaine; Cognition Disorders; Confusion; Disease Progression; Drug Therapy, Combination; Folic Acid; Frontal Lobe; Homocysteine; Humans; Hyperhomocysteinemia; Leukoaraiosis; Magnetic Resonance Imaging; Male; Methylmalonic Acid; Remission Induction; Seizures; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2005 |
Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample.
Topics: Aged; Antioxidants; Australia; Brain; Case-Control Studies; Causality; Creatinine; Cross-Sectional Studies; Depressive Disorder; Depressive Disorder, Major; Female; Folic Acid; Folic Acid Deficiency; Health Status Indicators; Health Surveys; Homocysteine; Humans; Hyperhomocysteinemia; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Personality Assessment; Predictive Value of Tests; Psychometrics; Reference Values; Statistics as Topic; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Relationship between polymorphism of methylenetetrahydrofolate dehydrogenase and congenital heart defect.
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; China; Female; Folic Acid; Gene Frequency; Genotype; Heart Defects, Congenital; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mutation; Polymorphism, Genetic | 2005 |
Adiponectin levels and cardiovascular risk factors in Japanese men with type 2 diabetes.
Topics: Adiponectin; Adult; Aging; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Folic Acid; gamma-Glutamyltransferase; Glycated Hemoglobin; Homocysteine; Humans; Intercellular Signaling Peptides and Proteins; Japan; Leukocyte Count; Lipids; Male; Middle Aged; Risk Factors; Smoking | 2005 |
Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Case-Control Studies; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pre-Eclampsia; Pregnancy; Vitamin B 12 | 2005 |
The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.
Topics: Amino Acid Substitution; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2005 |
Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.
Topics: Adult; Amino Acids; Female; Folic Acid; Folic Acid Deficiency; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Leucine; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Serine | 2005 |
Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors.
Topics: Adult; Aged; Alcohol Drinking; Animals; Blood Glucose; Blood Pressure; Coffee; Diabetes Mellitus, Type 2; Diet; Exercise; Female; Fishes; Folic Acid; Fruit; Glomerular Filtration Rate; Glycated Hemoglobin; Homocysteine; Humans; Linear Models; Male; Meat; Mediterranean Region; Metformin; Middle Aged; Nutritional Status; Surveys and Questionnaires; Triglycerides; Vegetables | 2005 |
Plasma homocysteine is related to folate intake but not training status.
Topics: Adult; Cross-Sectional Studies; Diet; Dietary Proteins; Energy Intake; Energy Metabolism; Exercise; Folic Acid; Homocysteine; Humans; Male; Regression Analysis; Sports; Thiamine; Vitamin B 6 | 2005 |
Effects of marathon running on plasma total homocysteine concentrations.
Topics: Adult; Blood Glucose; Body Composition; Fasting; Fatty Acids, Nonesterified; Folic Acid; Homocysteine; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Myocardial Infarction; Risk Factors; Running; Vitamin B 12; Waist-Hip Ratio | 2005 |
Reduced plasma homocysteine levels in levodopa/entacapone treated Parkinson patients.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cross-Sectional Studies; Drug Therapy, Combination; Enzyme Inhibitors; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Vitamin B 12 | 2005 |
Total homocysteine and its predictors in Dutch children.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Creatinine; Female; Folic Acid; Genotype; Homocysteine; Humans; Infant; Life Style; Male; Methylenetetrahydrofolate Reductase (NADPH2); Netherlands; Predictive Value of Tests; Vitamin B 12 | 2005 |
[The plasma homocysteine, folic acid and vitamin B12 levels in young people with high risk for cardiovascular disease and its relation to metylentetrahydrofolate reductase (MTHFR) gene polymorphism].
Topics: Adult; Cardiovascular Diseases; Cytosine; Female; Folic Acid; Heterozygote; Homocysteine; Humans; Immunoassay; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors; Thymine; Vitamin B 12 | 2005 |
Endothelial nitric oxide synthase -786T>C, but not 894G>T and 4a4b, polymorphism influences plasma homocysteine concentrations in persons with normal vitamin status.
Topics: Adult; Aged; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Vitamin B 12; Vitamin B 6; Vitamins | 2005 |
Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese Thais.
Topics: Adolescent; Adult; Body Weight; Case-Control Studies; Female; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Obesity; Polymorphism, Genetic; Thailand; Vitamin B 12 | 2005 |
Tribromomethane exposure and dietary folate deficiency in the formation of aberrant crypt foci in the colons of F344/N rats.
Topics: Animals; Body Weight; Colonic Neoplasms; Diet; Disinfectants; Dose-Response Relationship, Drug; Eating; Folic Acid; Folic Acid Deficiency; Homocysteine; Male; Rats; Rats, Inbred F344; Trihalomethanes; Water Supply | 2005 |
Simultaneous quantification of homocysteine and folate in human serum or plasma using liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, Liquid; Folic Acid; Homocysteine; Humans; Molecular Structure; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tetrahydrofolates; Time Factors | 2005 |
[The relationship between carotid artery atherosclerosis and hyperhomocysteinaemia].
Topics: Adult; Aged; Aged, 80 and over; Carotid Artery Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2005 |
Maternal total homocysteine concentration and neonatal size in India.
Topics: Adult; Birth Weight; Erythrocytes; Female; Folic Acid; Gestational Age; Homocysteine; Humans; India; Infant, Newborn; Infant, Small for Gestational Age; Male; Maternal Nutritional Physiological Phenomena; Population Surveillance; Pregnancy; Pregnancy Complications; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake.
Topics: Adult; Aged; Brain Ischemia; Case-Control Studies; Cohort Studies; Diet; Female; Folic Acid; Hemorrhage; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Nutritional Status; Odds Ratio; Polymorphism, Genetic; Prospective Studies; Registries; Risk; Stroke; Sweden; Vitamin B 12 | 2005 |
Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: the paradoxical effect of the superimposed type II diabetes mellitus condition.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Dementia, Vascular; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12 | 2005 |
Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Coronary Artery Disease; Female; Folic Acid; Genotype; Homocysteine; Humans; Korea; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Nutritional Status; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Vitamin B 12 | 2006 |
Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy.
Topics: Adult; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Male; Middle Aged; Triazines; Valproic Acid; Vitamin B 12 | 2005 |
Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh.
Topics: Adult; Aged; Areca; Bangladesh; Cohort Studies; Creatinine; Diagnosis, Differential; Diet, Vegetarian; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prevalence; Prospective Studies; Sex Factors; Smoking; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy.
Topics: Adult; Africa, Western; Betaine; Black People; Choline; Dietary Supplements; Female; Folic Acid; Gestational Age; Hematinics; Homocysteine; Humans; Netherlands Antilles; Nutritional Status; Postpartum Period; Predictive Value of Tests; Pregnancy; Regression Analysis | 2005 |
[Folic acid in hyperhomocysteinemia?].
Topics: Contraindications; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Long-Term Care; Risk Factors; Spinal Diseases; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Prevalence of hyperhomocysteinaemia, activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease.
Topics: Activated Protein C Resistance; Adult; Colitis, Ulcerative; Crohn Disease; Factor V; Factor VIII; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Male; Middle Aged; Mutation; Protein C; Prothrombin; Vitamin B 12 | 2005 |
Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans.
Topics: Aged; Bone Density; Female; Folic Acid; Hip; Homocysteine; Humans; Male; Methylmalonic Acid; Osteoporosis; Radiography; United States; Vitamin B 12 | 2005 |
Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics.
Topics: Adult; Biomarkers; Celiac Disease; Chromatography, High Pressure Liquid; DNA; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Prevalence; Prospective Studies; Radioimmunoassay; Risk Factors; Vitamin B 12 | 2005 |
Effect of homocysteine, folates, and cobalamin on endothelial cell- and copper-induced LDL oxidation.
Topics: Cells, Cultured; Copper; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kinetics; Lipoproteins, LDL; Reference Values; Umbilical Veins; Vitamin B 12 | 2005 |
G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism.
Topics: Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Female; Fluorescence; Folic Acid; Homocysteine; Humans; Jejunum; Male; Membrane Transport Proteins; Odds Ratio; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors; Thrombosis | 2005 |
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
Topics: Cell Proliferation; Cells, Cultured; DNA Modification Methylases; Embryo, Mammalian; Enzymes; Epigenesis, Genetic; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Methotrexate; Reproductive Techniques, Assisted; S-Adenosylmethionine; Stem Cells | 2005 |
Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alcoholism; Avitaminosis; Comorbidity; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methionine; Methylation; Middle Aged; Prevalence | 2005 |
The significance of homocysteine levels in schizophrenia.
Topics: Age Factors; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization Immunoassay; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Research Design; Schizophrenia; Sex Factors | 2005 |
[Plasma homocysteine concentration and its relationship with the development of preeclampsia. Effect of prenatal administration of folic acid].
Topics: Adolescent; Adult; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Hyperhomocysteinemia; Poverty; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Trimesters; Socioeconomic Factors | 2005 |
Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine.
Topics: Adult; Diet; Ethanol; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2005 |
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
Topics: Animals; Diet; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Pregnancy | 2005 |
Increased LDL+VLDL oxidizability and plasma homocysteine levels in chronic alcoholic patients.
Topics: Adult; Alcoholism; Apolipoproteins B; Aryldialkylphosphatase; Cholesterol, HDL; Female; Folic Acid; Homocysteine; Humans; Lipid Peroxidation; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Vitamin B 12 | 2005 |
Maternal plasma homocysteine concentrations are not increased in twin pregnancies.
Topics: Adult; Analysis of Variance; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Parity; Pregnancy; Pregnancy Outcome; Pregnancy, Multiple; Prenatal Care; Probability; Reference Values; Sensitivity and Specificity; Twins | 2005 |
A homocysteine metabolism-related dietary pattern and the risk of coronary heart disease in two independent German study populations.
Topics: Aged; Body Mass Index; Case-Control Studies; Coronary Disease; Diet; Female; Folic Acid; Germany; Homocysteine; Humans; Middle Aged; Multivariate Analysis; Risk Factors; Vitamin B 12 | 2005 |
Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Chi-Square Distribution; Dementia; Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Schizophrenia; Vitamin B 12 | 2005 |
Serum homocysteine, folate and risk of stroke: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study.
Topics: Age Factors; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Finland; Folic Acid; Follow-Up Studies; Hematinics; Homocysteine; Humans; Male; Middle Aged; Myocardial Ischemia; Odds Ratio; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Triglycerides | 2005 |
Hyperglycinemia due to folate deficiency in rats: evidence for the lack of involvement of the hepatic glycine cleavage system.
Topics: Amino Acid Oxidoreductases; Animals; Carrier Proteins; Diet; Eating; Folic Acid; Folic Acid Deficiency; Glycine; Homocysteine; Liver; Male; Multienzyme Complexes; Rats; Rats, Sprague-Dawley; Transferases; Weight Gain | 2005 |
Insulin resistance is not related to plasma homocysteine concentration in healthy premenapausal women.
Topics: Adolescent; Adult; Age Factors; Blood Glucose; Body Mass Index; Cholesterol, HDL; Female; Folic Acid; Homocysteine; Humans; Insulin; Insulin Resistance; Premenopause; Triglycerides; Uric Acid; Vitamin B 12 | 2006 |
Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000.
Topics: Adult; Aged; Dietary Supplements; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Nutrition Surveys; Reference Values; Time Factors; United States; Vitamin B 12 | 2005 |
The relation between homocysteine levels and development of Alzheimer's disease in mild cognitive impairment patients.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Creatinine; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Sex Characteristics; Thyrotropin; Vitamin B 12; Vitamins | 2005 |
Homocysteine and cognitive performance in the Framingham offspring study: age is important.
Topics: Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Pyridoxine; Regression Analysis; Risk Factors; Vitamin B 12 | 2005 |
Homocysteine and serum markers of immune activation in primary dystonia.
Topics: Adult; Aged; Anti-Dyskinesia Agents; Biomarkers; Botulinum Toxins; C-Reactive Protein; Chromatography, High Pressure Liquid; Dystonic Disorders; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Immunity; Male; Middle Aged; Vitamin B 12 | 2005 |
Low levels of vitamin B12 and venous thromboembolic disease in elderly men.
Topics: Age Factors; Aged; Biomarkers; Case-Control Studies; Creatinine; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Risk Assessment; Thromboembolism; Venous Thrombosis; Vitamin B 12; Vitamin B Deficiency | 2005 |
No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; France; Genotype; Homocysteine; Humans; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk Factors | 2005 |
Hyperhomocysteinaemia induced by dietary folate restriction causes kidney oxidative stress in rats.
Topics: Animals; Antioxidants; Chemokine CCL2; Folic Acid; Free Radical Scavengers; Glutathione Peroxidase; Homocysteine; Hyperhomocysteinemia; Kidney; Lipid Peroxidation; Male; Oxidative Stress; Proteins; Rats; Rats, Wistar; Receptors, LDL; Superoxide Dismutase; Vitamin B Deficiency; Weight Loss | 2005 |
Vitamin therapy may reduce hip fracture risk. Folate, B12 appear to reduce homocysteine levels.
Topics: Aged; Female; Folic Acid; Hip Fractures; Homocysteine; Humans; Male; Stroke; Vitamin B 12 | 2005 |
Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age.
Topics: Adult; Child Development; Child, Preschool; Cognition; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Intelligence; Memory; Poverty; Pregnancy; Prenatal Care; Psychomotor Performance; Vitamin B Complex; Zinc | 2005 |
Population references for plasma total homocysteine concentrations for U.S. children and adolescents in the post-folic acid fortification era.
Topics: Adolescent; Aging; Black People; Child; Child, Preschool; Female; Folic Acid; Food, Fortified; Hispanic or Latino; Homocysteine; Humans; Male; Mexican Americans; Osmolar Concentration; Reference Values; Sex Factors; White People | 2005 |
Hyperhomocysteinemia and cognitive function: more than just a casual link?
Topics: Aging; Cognition; Cognition Disorders; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors | 2005 |
Congenital heart defects and maternal biomarkers of oxidative stress.
Topics: Adult; Arkansas; Biomarkers; Case-Control Studies; Dipeptides; Female; Folic Acid; Glutathione; Glutathione Disulfide; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Life Style; Oxidative Stress; Pregnancy; Pregnancy Complications; Registries; Risk Factors; S-Adenosylhomocysteine; Vitamin B 6 | 2005 |
High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study.
Topics: Aged; Aged, 80 and over; Aging; Cognition; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Diet; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2005 |
Homocysteine and folate as risk factors for dementia and Alzheimer disease.
Topics: Aged; Aging; Alzheimer Disease; Cognition; Cohort Studies; Cross-Sectional Studies; Dementia; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Italy; Male; Prospective Studies; Risk Factors; Seroepidemiologic Studies | 2005 |
Plasma homocysteine, vitamin B12 and folate levels in age-related macular degeneration.
Topics: Aged; Aged, 80 and over; Choroidal Neovascularization; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Exudates and Transudates; Female; Folic Acid; Homocysteine; Humans; Luminescent Measurements; Macular Degeneration; Male; Middle Aged; Prospective Studies; Vitamin B 12 | 2006 |
Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate.
Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases, Metabolic; Child; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Plasma homocysteine levels in patients with isolated coronary artery ectasia.
Topics: Biomarkers; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Dilatation, Pathologic; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prospective Studies; Vitamin B 12 | 2005 |
Effects of short-term supplementation with folic acid on different oxidative stress parameters in patients with hypertension.
Topics: Adult; Aged; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hypertension; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Vitamin B Complex | 2005 |
Association of B vitamins status and homocysteine levels in elderly Taiwanese.
Topics: Age Factors; Aged; Aged, 80 and over; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Health Surveys; Homocysteine; Humans; Hyperhomocysteinemia; Male; Nutrition Surveys; Nutritional Status; Sex Factors; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency; Vitamin B Complex | 2005 |
[Homocysteinemia].
Topics: Aged; Diagnosis, Differential; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Prognosis; Risk Assessment; Risk Factors; Time Factors; Vitamin B 12 | 2005 |
[Nutrition as heart issue: micronutrients protect women's hearts].
Topics: Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Micronutrients; Nutritional Requirements; Risk Factors; Sex Factors; Vitamin B 12 | 2005 |
Heavy alcohol intake, homocysteine and Type 2 diabetes.
Topics: Alcohol Drinking; Arteriosclerosis; Blood Glucose; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Folic Acid; gamma-Glutamyltransferase; Homocysteine; Humans; Male; Middle Aged; Prevalence; Risk Factors; Vitamin B 12 | 2005 |
Long-term consumption of a raw food diet is associated with favorable serum LDL cholesterol and triglycerides but also with elevated plasma homocysteine and low serum HDL cholesterol in humans.
Topics: Adult; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diet, Vegetarian; Female; Folic Acid; Fruit; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Triglycerides; Vegetables; Vitamin B 12 | 2005 |
[Folate reduces monocyte chemoattractant protein-1 expression in rats with hyperhomocysteinemia].
Topics: Animals; Aorta; Chemokine CCL2; Endothelium, Vascular; Folic Acid; Homocysteine; Hyperhomocysteinemia; Leukocytes, Mononuclear; Male; Methionine; Random Allocation; Rats; Rats, Sprague-Dawley | 2005 |
[Effect of the supplementation of vitamins B12, B6 and folic acid on homocysteine and plasmatic lipids in patients with hyperlipoproteinemic secondary type IV].
Topics: Adult; Aged; Biomarkers; Cholesterol, HDL; Coronary Disease; Folic Acid; Homocysteine; Humans; Hyperlipoproteinemia Type IV; Lipids; Lipoproteins, LDL; Male; Middle Aged; Risk Factors; Triglycerides; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2005 |
Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lactation; Life Style; Methylmalonic Acid; Nutritional Requirements; Nutritional Status; Postpartum Period; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
[Effect of low doses of folic acid on selected biochemical atherosclerosis risk factors--preliminary study].
Topics: Adult; Apolipoprotein A-I; Atherosclerosis; Cholesterol, LDL; Female; Fibrinogen; Folic Acid; Hematinics; Homocysteine; Humans; Male; Risk Factors; Time Factors | 2005 |
Serum folate and homocysteine levels in patients with obsessive-compulsive disorder.
Topics: Adolescent; Adult; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales | 2005 |
Homocysteine and B vitamins in mild cognitive impairment and dementia.
Topics: Aged; Cognition Disorders; Dementia; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2005 |
Young hemodialysis patients are exposed to hyperhomocysteinemia.
Topics: Adult; Alcohol Drinking; Cardiovascular Diseases; Cross-Sectional Studies; Electrocardiography; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Ischemia; Prognosis; Prospective Studies; Renal Dialysis; Risk Factors | 2005 |
[Assessment of metabolic atherosclerosis risk factors in progeny of patients with past ischemic stroke].
Topics: Adult; Apolipoprotein A-I; Apolipoproteins B; Biomarkers; Brain Ischemia; C-Reactive Protein; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Female; Fibrinogen; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Life Style; Lipoprotein(a); Male; Risk Factors; Stroke; Time Factors; Triglycerides; von Willebrand Factor | 2005 |
Do low doses of folic acid result in maximum lowering of homocysteine?
Topics: Dietary Supplements; Dose-Response Relationship, Drug; Drug Synergism; Evidence-Based Medicine; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Vitamin B 12; Vitamin B 6 | 2005 |
Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery.
Topics: Betaine; Choline; Chromatography, Liquid; Creatinine; Cross-Sectional Studies; Female; Fetal Blood; Folic Acid; Health Status Indicators; Homocysteine; Humans; Infant, Newborn; Methylation; Oxidation-Reduction; Pregnancy; Regression Analysis; Sarcosine; Vitamin B 12 | 2005 |
Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study.
Topics: Aged; Aged, 80 and over; Aging; Cognition; Cross-Sectional Studies; Dementia; Female; Folic Acid; Homocysteine; Humans; Linear Models; Longitudinal Studies; Male; Neuropsychological Tests; Prospective Studies; Risk Factors; Vitamin B 12 | 2005 |
Chemokine RANTES is upregulated in monocytes from patients with hyperhomocysteinemia.
Topics: Adult; Chemokine CCL5; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipopolysaccharides; Male; Middle Aged; Monocytes; RNA, Messenger | 2005 |
Folate, vitamin B12, and homocysteine levels in South Asian women with growth-retarded fetuses.
Topics: Adult; Age Factors; Birth Weight; Cohort Studies; Female; Fetal Blood; Fetal Development; Fetal Growth Retardation; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Luminescent Measurements; Pakistan; Pregnancy; Pregnancy Outcome; Prospective Studies; Social Class; Ultrasonography, Prenatal; Vitamin B 12 | 2005 |
The effect of MTHFR(C677T) genotype on plasma homocysteine concentrations in healthy children is influenced by gender.
Topics: Analysis of Variance; Child; Cross-Sectional Studies; Diet; Female; Folic Acid; Genotype; Greece; Homocysteine; Humans; Male; Mental Recall; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Sex Factors; Vitamin B 12 | 2006 |
Vitamin Intervention For Stroke Prevention trial: an efficacy analysis.
Topics: Aged; Disease-Free Survival; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Ischemia; Male; Middle Aged; Models, Statistical; Randomized Controlled Trials as Topic; Stroke; Time Factors; Treatment Outcome; Vitamin B 12; Vitamins | 2005 |
[Untreated homocystinuria in adulthood].
Topics: Adult; Age Factors; Angina Pectoris; Betaine; Diagnosis, Differential; Drug Therapy, Combination; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Intervertebral Disc Displacement; Lens Subluxation; Male; Marfan Syndrome; Myopia; Osteoporosis; Retinal Detachment; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2005 |
Regulation of homocysteine-induced MMP-9 by ERK1/2 pathway.
Topics: Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Folic Acid; Homocysteine; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Oxidative Stress; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, G-Protein-Coupled | 2006 |
Are homocysteine and MTHFR genotype polymorphism associated with arteriovenous fistula patency?
Topics: Arteriovenous Shunt, Surgical; Confounding Factors, Epidemiologic; Diet; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Riboflavin; Risk Factors; Thrombophilia; Thrombosis | 2005 |
Plasma total homocysteine levels in stroke patients screened for the vitamin intervention for stroke prevention clinical trial in the era of folate fortification.
Topics: Adult; Aged; Canada; Fasting; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Middle Aged; Reproducibility of Results; Stroke; United States; Vitamins | 2006 |
Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study.
Topics: Aged; Biomarkers; Cross-Sectional Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Memory; Memory Disorders; Prospective Studies; Risk Factors; Vitamin B 12 | 2005 |
The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Coronary Artery Disease; Cystathionine beta-Synthase; Environment; Erythrocytes; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Polymorphism, Genetic; Risk Factors; Vitamin B 12; Vitamin B 6 | 2005 |
Hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C-->T and 1298A-->C mutations in patients with inflammatory bowel disease.
Topics: Adult; Confidence Intervals; Data Interpretation, Statistical; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Odds Ratio; Prevalence; Sex Factors; Thromboembolism; Vitamin B 12 | 2005 |
Changes in plasma homocysteine levels of rats with experimentally induced hypothyroidism and hyperthyroidism.
Topics: Animals; Antithyroid Agents; Cholesterol; Folic Acid; Homocysteine; Hyperthyroidism; Hypothyroidism; Lipids; Male; Propylthiouracil; Rats; Rats, Wistar; Thyroid Function Tests; Thyroxine; Vitamin B 12 | 2005 |
Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alleles; Case-Control Studies; Coronary Artery Disease; Female; Ferredoxin-NADP Reductase; Folic Acid; France; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Transcobalamins; Vitamin B 12; White People | 2005 |
Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Brain; Causality; Cerebral Amyloid Angiopathy; Cognition Disorders; Creatinine; Female; Folic Acid; Homocysteine; Humans; Levodopa; Male; Memory Disorders; Middle Aged; Neurodegenerative Diseases; Parkinson Disease; Predictive Value of Tests; Vitamin B 12 | 2005 |
Design and statistical issues in the homocysteinemia in kidney and end stage renal disease (HOST) study.
Topics: Adult; Cause of Death; Double-Blind Method; Folic Acid; Homocysteine; Hospitals, Veterans; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Middle Aged; Multicenter Studies as Topic; Patient Selection; Prospective Studies; Pyridoxine; Randomized Controlled Trials as Topic; Renal Dialysis; Research Design; Treatment Outcome; Vitamin B 12 | 2004 |
[For coronary disease patients risky].
Topics: Adult; Clinical Trials as Topic; Coronary Disease; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Reference Values; Risk Factors; Vitamin B 6; Vitamins | 2005 |
B vitamins and homocysteine.
Topics: Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Stroke; Vitamin B 12; Vitamin B 6 | 2005 |
Altered vitamin B12 status in recreational endurance athletes.
Topics: Adult; Biomarkers; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Nutritional Status; Physical Endurance; Vitamin B 12; Vitamin B Complex | 2005 |
Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part II).
Topics: Adolescent; Adult; Aged; Ambulatory Care; Brain; Demography; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Vitamin B 12 | 2005 |
Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part I).
Topics: Adolescent; Adult; Aged; Brain; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Severity of Illness Index; Vitamin B 12 | 2005 |
Retinal vein occlusion, homocysteine, and methylene tetrahydrofolate reductase genotype.
Topics: Aged; Case-Control Studies; DNA Mutational Analysis; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Genetic; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2005 |
Plasma homocysteine and lipoprotein (a) levels in Turkish patients with metabolic syndrome.
Topics: Adult; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; Lipoprotein(a); Male; Metabolic Syndrome; Middle Aged; Reference Values; Risk Factors; Statistics as Topic; Turkey; Vitamin B 12 | 2005 |
The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Glycine N-Methyltransferase; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2005 |
Plasma total homocysteine and gallstone in middle-aged Japanese men.
Topics: Alcohol Drinking; Blood Glucose; Coronary Disease; Diet; Folic Acid; Gallstones; gamma-Glutamyltransferase; Homocysteine; Humans; Japan; Lipids; Male; Middle Aged; Risk Factors; Smoking | 2005 |
Anger attacks in major depressive disorder and serum levels of homocysteine.
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Anger; Creatinine; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Severity of Illness Index; Smoking; Surveys and Questionnaires; Time Factors; Vitamin B 12 | 2006 |
Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh.
Topics: Adult; Arsenic; Arsenicals; Bangladesh; Cacodylic Acid; Creatine; Creatinine; Cross-Sectional Studies; Environmental Exposure; Environmental Monitoring; Female; Folic Acid; Fresh Water; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Water Pollutants, Chemical | 2005 |
Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging.
Topics: Aged; Aged, 80 and over; Aging; California; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Dementia; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Hispanic or Latino; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Regression Analysis; Vitamin B Complex | 2005 |
Folate, but not homocysteine, predicts the risk of fracture in elderly persons.
Topics: Aged; Aged, 80 and over; Bone Diseases, Metabolic; Chromatography, High Pressure Liquid; Confounding Factors, Epidemiologic; Female; Folic Acid; Fractures, Bone; Homocysteine; Humans; Italy; Male; Multivariate Analysis; Risk Factors | 2005 |
Elevated plasma homocysteine in obese schoolchildren with early atherosclerosis.
Topics: Atherosclerosis; Body Mass Index; Brachial Artery; Carotid Artery, Internal; Case-Control Studies; Child; Dyslipidemias; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Obesity; Regional Blood Flow; Tunica Intima; Tunica Media; Ultrasonography; Vitamin B 12 | 2006 |
Elevated homocysteine levels in patients with end-stage renal disease.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors; Statistics, Nonparametric; Vitamin B 12 | 2005 |
[Folate and homocysteine levels during pregnancy affect DNA methylation in human placenta].
Topics: Adult; DNA Methylation; Embryonic Development; Female; Folic Acid; Homocysteine; Humans; Immunohistochemistry; Methylenetetrahydrofolate Reductase (NADPH2); Placenta; Polymorphism, Restriction Fragment Length; Pregnancy; Pregnancy Trimester, Second | 2005 |
Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the United States: analysis of data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-2002.
Topics: Adolescent; Adult; Age Distribution; Aged; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Nutrition Surveys; Prevalence; Sex Distribution; United States | 2006 |
Serum homocysteine concentration of US adults associated with fortified cereal consumption.
Topics: Adult; Age Factors; Cardiovascular Diseases; Cross-Sectional Studies; Edible Grain; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Mental Recall; Middle Aged; Multivariate Analysis; Nutrition Surveys; Nutritional Requirements; Regression Analysis; Sex Factors; United States | 2005 |
Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study.
Topics: Adult; Case-Control Studies; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Prospective Studies; Prostatic Neoplasms; Risk; Sweden; Vitamin B 12 | 2006 |
Erythrocyte membrane acetylcholinesterase activity in subjects with MTHFR 677C-->T genotype.
Topics: Acetylcholinesterase; Adult; Alanine; Cytidine; Erythrocyte Membrane; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Dehydrogenase (NADP); Phenylalanine | 2006 |
Plasma reduced homocysteine and other aminothiol concentrations in patients with CKD.
Topics: Adult; Aged; Atherosclerosis; Biomarkers; C-Reactive Protein; Chronic Disease; Cysteine; Dipeptides; Female; Folic Acid; Glutathione; Hemodiafiltration; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Oxidation-Reduction; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Vitamin B 12 | 2006 |
Effects of folic acid and magnesium on the production of homocysteine-induced extracellular matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells.
Topics: Animals; Aorta; Cells, Cultured; Culture Media; Enzyme Induction; Folic Acid; Homocysteine; Magnesium Sulfate; Male; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley | 2006 |
Plasma hyperhomocysteinemia, MTHFR polymorphism and thromboembolic disease: an example of gene-nutrition interactions in chronic disease.
Topics: Chronic Disease; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Thromboembolism; Vitamin B 12; Vitamin B 6 | 2005 |
Influence of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, B vitamins and other factors on plasma homocysteine and risk of thromboembolic disease in Chinese.
Topics: Adult; Aged; Aged, 80 and over; Coronary Disease; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymorphism, Genetic; Risk Factors; Thromboembolism; Vitamin B 12; Vitamin B 6 | 2005 |
Effects of chronic ethanol ingestion and folate deficiency on the activity of 10-formyltetrahydrofolate dehydrogenase in rat liver.
Topics: Amidohydrolases; Animals; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Ethanol; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Organ Size; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Sprague-Dawley; Vitamins; Weight Gain | 2005 |
Factors involved in baseline hyperhomocysteinemia in renal transplantation.
Topics: Adult; Aged; C-Reactive Protein; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prospective Studies; Reference Values; Vitamin B 12 | 2005 |
Homocysteine in assisted reproduction: does oestradiol influence homocysteine levels?
Topics: Adult; Estradiol; Female; Folic Acid; Homocysteine; Humans; Infertility, Female; Reproductive Techniques, Assisted; Vitamin B 12 | 2006 |
Plasma homocysteine and vascular disease in psychogeriatric patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Confusion; Dementia; Dementia, Vascular; Depressive Disorder; Female; Folic Acid; Homocysteine; Humans; Kidney Function Tests; Male; Middle Aged; Natriuretic Peptide, Brain; Neuropsychological Tests; Peptide Fragments; Reference Values; Risk Factors; Vitamin B 12 | 2006 |
Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxal Phosphate; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2006 |
Increased plasma protein homocysteinylation in hemodialysis patients.
Topics: Adult; Aged; Blood Proteins; Cardiovascular Diseases; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; In Vitro Techniques; Male; Middle Aged; Models, Molecular; Protein Binding; Protein Processing, Post-Translational; Renal Dialysis; Serum Albumin; Uremia; Vitamin B 12; Vitamin B 6; Xenobiotics | 2006 |
The association between plasma homocysteine and holo-transcobalamin and the transcobalamin 776C-->G polymorphism is influenced by folate in the absence of supplementation and fortified diet.
Topics: Folic Acid; Food, Fortified; Homocysteine; Humans; Transcobalamins | 2006 |
Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study.
Topics: Age Distribution; Aged; Bone Density; Cohort Studies; Confidence Intervals; Female; Folic Acid; Hematologic Tests; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Regression Analysis; Sex Distribution; Vitamin B 12 | 2006 |
Erythrocyte folate, plasma folate and plasma homocysteine during normal pregnancy and postpartum: a longitudinal study comprising 404 Danish women.
Topics: Adult; Denmark; Erythrocytes; Female; Folic Acid; Gestational Age; Guideline Adherence; Homocysteine; Humans; Lactation; Longitudinal Studies; Postpartum Period; Pregnancy | 2006 |
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Pyridoxal Phosphate; Reference Values; Valproic Acid; Vitamin B 12 | 2006 |
Dietary and genetic determinants of homocysteine levels among Mexican women of reproductive age.
Topics: Adolescent; Adult; Alleles; Chromatography, High Pressure Liquid; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Polymerase Chain Reaction; Polymorphism, Genetic; Radioimmunoassay; Surveys and Questionnaires; Vitamin B 12 | 2006 |
Homocysteine levels and glucose metabolism in non-obese, non-diabetic chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Blood Pressure; Chronic Disease; Clozapine; Community Mental Health Centers; Female; Folic Acid; Homeostasis; Homocysteine; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Nutrition Assessment; Olanzapine; Prediabetic State; Psychotic Disorders; Reference Values; Risk Factors; Risperidone; Schizophrenia; Sex Factors; Statistics as Topic; Waist-Hip Ratio | 2006 |
Relationship between plasma S-adenosylhomocysteine concentration and glomerular filtration rate in children.
Topics: Adolescent; Child; Child, Preschool; Congenital Hypothyroidism; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Infant; Kidney Diseases; S-Adenosylhomocysteine; Vitamin B 12 | 2006 |
[Hyperhomocysteinemia as a vascular risk factor in chronic hemodialysis patients].
Topics: Atherosclerosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Methylenetetrahydrofolate Reductase (NADPH2); Renal Dialysis; Risk Factors; Thrombosis; Vitamin B 12; Vitamin B Complex | 2005 |
The maternal combined supplementation of folic acid and Vitamin B(12) suppresses ethanol-induced developmental toxicity in mouse fetuses.
Topics: Abnormalities, Drug-Induced; Alcoholic Intoxication; Animals; Bone and Bones; Dietary Supplements; Embryo Implantation; Embryo Loss; Ethanol; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Mice; Pregnancy; Vitamin B 12 | 2006 |
Folic acid pretreatment prevents the reduction of Na(+),K(+)-ATPase and butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia.
Topics: Animals; Butyrylcholinesterase; Cerebral Cortex; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thiobarbituric Acid Reactive Substances; Vitamin B Complex | 2006 |
Homocysteine and its determinants in nondialyzed chronic kidney disease patients.
Topics: Anthropometry; Case-Control Studies; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kidney Function Tests; Linear Models; Male; Middle Aged; Nutrition Assessment; Nutritional Status; Prevalence; Vitamin B 12 | 2006 |
Three Bs for the brain.
Topics: Aged; Dementia; Folic Acid; Homocysteine; Humans; Male; Thinking; Vitamin B 12; Vitamin B 6 | 2005 |
Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap.
Topics: Chromatography, Liquid; DNA Methylation; Erythrocytes; Folic Acid; Homocysteine; Homozygote; Humans; Hydroxocobalamin; Male; Mass Spectrometry; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12; Vitamin B Complex | 2006 |
Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study.
Topics: Adult; Aged; Analysis of Variance; Coffee; Cross-Sectional Studies; Diet; Diet Records; Fabaceae; Female; Folic Acid; Fruit; Greece; Homocysteine; Humans; Life Style; Male; Middle Aged; Nutrition Policy; Smoking; Solanum tuberosum; Surveys and Questionnaires; Vegetables; Vitamin B 12 | 2006 |
Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study.
Topics: Adult; Age Factors; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Iran; Male; Middle Aged; Nutrition Surveys; Prevalence; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
Topics: Adult; Chromatography, High Pressure Liquid; Dietary Supplements; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Riboflavin | 2006 |
Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract.
Topics: Animals; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Garlic; Homocysteine; Hyperhomocysteinemia; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2006 |
Why is homocysteine elevated in renal failure and what can be expected from homocysteine-lowering?
Topics: Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kidney Function Tests; Male; Prognosis; Renal Dialysis; Risk Assessment; Severity of Illness Index; Treatment Outcome; Vitamin B 6 | 2006 |
Folate supplementation: too much of a good thing?
Topics: Carcinogens; Cardiovascular Diseases; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Neoplasms; Neural Tube Defects; Preconception Care; Vitamin B Complex | 2006 |
Diagnostic significance of urinary thiodiglycolic acid as a possible tool for studying the role of vitamins B12 and folates in the metabolism of thiolic substances.
Topics: Adult; Betaine; Biomarkers; Folic Acid; Homocysteine; Humans; Injections, Intramuscular; Leucovorin; Male; Sulfhydryl Compounds; Thioglycolates; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
Serum homocysteine, vitamin B 12 and folic acid levels in different types of glaucoma.
Topics: Aged; Analysis of Variance; Case-Control Studies; Exfoliation Syndrome; Female; Folic Acid; Glaucoma; Glaucoma, Open-Angle; Homocysteine; Humans; Male; Middle Aged; Osmolar Concentration; Vitamin B 12 | 2006 |
Influence of folate serum concentration on plasma homocysteine levels in HIV-positive patients exposed to protease inhibitors undergoing HAART.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cross-Sectional Studies; Female; Folic Acid; HIV Infections; Homocysteine; Humans; Hyperhomocysteinemia; Logistic Models; Male; Predictive Value of Tests; Protease Inhibitors; Risk Factors; Time Factors | 2006 |
Hyperhomocysteinemia in chronic renal failure patients: relation to tissue factor and platelet aggregation.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Platelet Aggregation; Renal Dialysis; Thromboplastin; Vitamin B 12; Vitamin B 6 | 2006 |
Low folic acid status and its association with anaemia in urban adolescent girls and women of childbearing age in Sri Lanka.
Topics: Adolescent; Adult; Anemia; Body Mass Index; Diet; Female; Ferritins; Folic Acid; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Iron; Population Surveillance; Prevalence; Socioeconomic Factors; Sri Lanka; Urban Health | 2006 |
Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations.
Topics: Adolescent; Adult; Africa, Western; Alleles; Europe; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Polymorphism, Genetic; Regression Analysis; Vitamin B 12 | 2006 |
Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.
Topics: Aged; Aged, 80 and over; England; Female; Folic Acid; Gene Expression Regulation, Enzymologic; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic | 2006 |
Homocysteine trials--clear outcomes for complex reasons.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylation; Myocardial Infarction; Secondary Prevention; Vascular Diseases; Vitamin B 12; Vitamin B 6 | 2006 |
Serum homocysteine concentration as a marker of nutritional status of healthy subjects in Crete, Greece.
Topics: Adult; Aged; Atherosclerosis; Biomarkers; Diet Records; Diet, Mediterranean; Feeding Behavior; Female; Folic Acid; Greece; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Risk Factors; Rural Health; Vitamin B Complex | 2006 |
Improvement in stroke mortality in Canada and the United States, 1990 to 2002.
Topics: Adult; Age Distribution; Aged; Canada; Edible Grain; England; Folic Acid; Food, Fortified; Homocysteine; Humans; Linear Models; Middle Aged; Racial Groups; Risk Factors; Sex Factors; Stroke; United States; Wales | 2006 |
[Relations between serum homocysteine and folic acid levels with congenital heart disease].
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Infant; Male; Parents; Vitamin B 12; Young Adult | 2005 |
Hyperhomocysteinemia increases damage on brain slices exposed to in vitro model of oxygen and glucose deprivation: prevention by folic acid.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Folic Acid; Glucose; Homocysteine; Hyperhomocysteinemia; Hypoxia; Hypoxia-Ischemia, Brain; In Vitro Techniques; Lactate Dehydrogenases; Male; Rats; Rats, Wistar; Vitamin A; Vitamin B Complex | 2006 |
Impact of renal function or folate status on altered plasma homocysteine levels in hypothyroidism.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Cystatins; Data Interpretation, Statistical; Female; Folic Acid; Homocysteine; Humans; Hypothyroidism; Kidney; Male; Middle Aged; Nephelometry and Turbidimetry; Vitamin B 12 | 2006 |
Maternal folate receptor autoantibodies and cleft lip and/or palate.
Topics: Adult; Autoantibodies; Carrier Proteins; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folate Receptors, GPI-Anchored; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Receptors, Cell Surface | 2006 |
Hyperhomocysteinemia in patients with arterial occlusive disease.
Topics: Aged; Aged, 80 and over; Arterial Occlusive Diseases; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prospective Studies; Risk Assessment; Risk Factors; Vitamin B 12 | 2006 |
Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis.
Topics: Adult; Aged; Antithrombin III; Female; Folic Acid; Hemostasis; Homocysteine; Humans; Hyperhomocysteinemia; Liver Cirrhosis, Biliary; Male; Middle Aged; Peptide Hydrolases; Platelet Function Tests; Thrombomodulin; Thrombophilia; Thromboplastin; Vitamin B 12; Vitamin B 6 | 2006 |
Testing the homocysteine hypothesis in end-stage renal disease: Problems and a possible solution.
Topics: Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Vitamin B 12 | 2006 |
Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects.
Topics: Acute Disease; Adult; Aged; Blood Coagulation; Case-Control Studies; Coronary Artery Disease; Diabetes Mellitus; Drug Resistance; Fibrin; Fibrinolytic Agents; Folic Acid; Hematinics; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Male; Middle Aged; Permeability; Recombinant Proteins; Tissue Plasminogen Activator | 2006 |
Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome?
Topics: Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Mutation; Polymorphism, Single Nucleotide; Regression Analysis; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine | 2006 |
Folate supplementation does not affect biochemical markers of bone turnover.
Topics: Biomarkers; Bone and Bones; Bone Remodeling; Collagen; Collagen Type I; Diet; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Osteocalcin; Peptide Fragments; Peptides; Procollagen; Vitamin B 12; Vitamin B Complex | 2006 |
Alcohol consumption and plasma homocysteine.
Topics: Alcohol Drinking; Cross-Sectional Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Odds Ratio; Smoking; Surveys and Questionnaires; Vitamin B 12 | 2005 |
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Betaine; Choline; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Sex Factors; Surveys and Questionnaires; Vitamin B Complex | 2006 |
Vitamin B12 and vitamin B6 supplementation is needed among adults with phenylketonuria (PKU).
Topics: Adolescent; Adult; Diet, Protein-Restricted; Female; Folic Acid; Homocysteine; Humans; Male; Phenylketonurias; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency | 2006 |
Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele.
Topics: Adolescent; Child; Child, Preschool; Disabled Children; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Meningomyelocele; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Sex Factors | 2006 |
Hyperhomocysteinemia predicts total and cardiovascular mortality in high-risk women.
Topics: Aged; Cardiovascular Diseases; Cohort Studies; Coronary Angiography; Coronary Artery Disease; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Longitudinal Studies; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Postmenopause; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Factors; Survival Rate; Time Factors; White People | 2006 |
Factor V Leiden, pregnancy complications and adverse outcomes: the Hordaland Homocysteine Study.
Topics: Adult; Factor V; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Maternal Age; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Norway; Odds Ratio; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Retrospective Studies; Risk Factors; Smoking; Vitamin B 12 | 2006 |
The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.
Topics: Biomarkers; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy; Prospective Studies | 2006 |
Kazakhstan: a folate-deficient area?
Topics: Adult; Aged; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Japan; Kazakhstan; Male; Middle Aged; Nutrition Assessment; Nutritional Status; Prevalence; Vegetables | 2006 |
Folate supplementation and cardiovascular disease.
Topics: Cardiovascular Diseases; Folic Acid; Hematinics; Homocysteine; Humans; Randomized Controlled Trials as Topic; Stroke; Vitamin B 12; Vitamin B 6 | 2006 |
Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats.
Topics: Animals; Colon; Deficiency Diseases; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Folic Acid; Glutathione; Glutathione Peroxidase; Glycine N-Methyltransferase; Homocysteine; Liver; Male; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenium | 2006 |
Hyperhomocysteinemia can be ameliorated by dimethylsulfoniopropionate in place of folic acid in mice.
Topics: Animals; Betaine; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Hyperhomocysteinemia; Injections, Intraperitoneal; Kinetics; Male; Mice; Mice, Inbred ICR; Sulfonium Compounds | 2006 |
Antiepileptic drugs: a case report in a pregnancy with a neural tube defect.
Topics: Adult; Anticonvulsants; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Myoclonic Epilepsy, Juvenile; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy, Multiple; Triazines; Triplets; Vitamin B Complex | 2006 |
Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients.
Topics: Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Korea; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors; Schizophrenia | 2006 |
Drinking tea is associated with lower plasma total homocysteine in older women.
Topics: Aged; Aged, 80 and over; Biomarkers; Cross-Sectional Studies; Diet; Erythrocytes; Female; Flavonoids; Folic Acid; Gallic Acid; Homocysteine; Humans; Mental Recall; Phenols; Polyphenols; Tea | 2006 |
Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia.
Topics: Adult; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; DNA; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Sulfhydryl Compounds; Tetrahydrofolates; Vitamin B 12; Vitamin E | 2006 |
Mild hyperhomocysteinemia and the common C677T polymorphism of methylene tetrahydrofolate reductase gene are not associated with the metabolic syndrome in Type 2 diabetes.
Topics: Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Insulin Resistance; Linear Models; Male; Metabolic Syndrome; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Obesity; Polymorphism, Genetic; Triglycerides; Vitamin B 12 | 2006 |
Rationale and design for the CARDIOVIT Study (Cardiovit, Atherosclerotic vascular disease and hypeRhomocysteinemia: an epiDemiological study in Indians, additionally evaluating the effect of Oral VITamin supplementation).
Topics: Adult; Antioxidants; Atherosclerosis; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Middle Aged; Prevalence; Randomized Controlled Trials as Topic; Risk Factors; Treatment Outcome; Vitamin B Complex; Vitamins | 2006 |
Cardiovascular risk assessment and homocysteine and leptin levels in peritoneal dialysis and hemodialysis patients.
Topics: Adult; C-Reactive Protein; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Leptin; Lipids; Peritoneal Dialysis; Renal Dialysis; Risk Assessment; Risk Factors; Vitamin B Complex | 2005 |
Is elevated post-methionine load homocysteinaemia a risk factor for cervical artery dissection?
Topics: Adult; Carotid Artery, Internal; Carotid Artery, Internal, Dissection; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Methionine; Risk Factors; Up-Regulation; Vertebral Artery Dissection | 2006 |
Total serum homocysteine, folate and vitamin B12 in a Greek school age population.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Age Factors; Aging; Blood Pressure; Cardiovascular Diseases; Child; Child Nutritional Physiological Phenomena; Female; Folic Acid; Greece; Health Surveys; Homocysteine; Humans; Hyperhomocysteinemia; Male; Reference Values; Risk Factors; Sex Factors; Social Class; Vitamin B 12; Vitamin B Complex | 2006 |
Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Homocystine; Mice; Neural Tube Defects; Pregnancy; Random Allocation; Teratogens; Valproic Acid; Vitamin B 12 | 2006 |
Carotid intima-media thickness in coronary slow flow: relationship with plasma homocysteine levels.
Topics: Aged; Carotid Arteries; Carotid Artery Diseases; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Reference Values; Tunica Intima; Tunica Media | 2006 |
Development of a new standard reference material: SRM 1955 (homocysteine and folate in human serum).
Topics: Folic Acid; Homocysteine; Humans; Mass Spectrometry; Molecular Structure; Reference Standards; United States; United States Public Health Service | 2006 |
Folic acid, vitamin B12, MTHFR genotypes, and plasma homocysteine.
Topics: Aged; Aortic Aneurysm, Abdominal; Atherosclerosis; Carotid Artery Diseases; Folic Acid; Genotype; Homocysteine; Humans; Ischemia; Leg; Male; Methylenetetrahydrofolate Reductase (NADPH2); Peripheral Vascular Diseases; Risk Factors; Vitamin B 12 | 2006 |
Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis.
Topics: Adult; Anti-Inflammatory Agents; Black People; Dietary Fats; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Interferons; Iron; Magnetic Resonance Imaging; Male; Methylation; Multiple Sclerosis; Nutritional Status; Patient Compliance; Pilot Projects; Prednisone; Vitamin B 12; White People | 2006 |
G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population.
Topics: Absorption; Aged; Aged, 80 and over; Amino Acid Substitution; Biological Transport; Blood Pressure; Diet; Erythrocytes; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Membrane Transport Proteins; Models, Biological; New South Wales; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Vitamin B Complex | 2006 |
The challenge of the unacceptable high mortality in end-stage kidney disease: is folic acid the answer?
Topics: Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic | 2006 |
Plasma homocysteine levels and vitamin B status in patients with Pseudoexfoliation syndrome.
Topics: Aged; Exfoliation Syndrome; Eye; Female; Folic Acid; Glaucoma; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Retinal Vein Occlusion; Risk Factors; Turkey; Vitamin B 12; Vitamin B 6 | 2006 |
Preoperative folate and homocysteine status in patients undergoing major surgery.
Topics: Anesthetics, Inhalation; Dietary Supplements; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Multivariate Analysis; Nitrous Oxide; Nutrition Assessment; Nutritional Status; Preoperative Care; Surveys and Questionnaires | 2006 |
Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide.
Topics: Aged; Arginine; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Postmenopause; Risk Factors; Vitamin B 12 | 2006 |
The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy?
Topics: Adult; Cross-Sectional Studies; Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Hypersensitivity; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymorphism, Genetic; Riboflavin; Risk Assessment; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6 | 2006 |
Elevated second trimester serum homocysteine levels in women with gestational diabetes mellitus.
Topics: Adult; Body Mass Index; Cross-Sectional Studies; Diabetes, Gestational; Female; Folic Acid; Gestational Age; Glucose Intolerance; Homocysteine; Humans; Pregnancy; Pregnancy Trimester, Second; Reference Values; Vitamin B 12 | 2006 |
[Lowering plasma homocysteine with vitamins B6, B12, and folic acid. Effect on lipids concentration in patients with secondary hyperlipoproteinemia type IV, with and without Lovastatina treatment].
Topics: Aged; Anticholesteremic Agents; Folic Acid; Homocysteine; Humans; Hyperlipoproteinemia Type IV; Lipids; Lovastatin; Middle Aged; Time Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2006 |
[Homocysteine level, relationship with cardiovascular risk factors in selected Polish population].
Topics: Adult; Aged; Coronary Artery Disease; Environmental Monitoring; Epidemiological Monitoring; Female; Folic Acid; Health Status; Homocysteine; Humans; Life Style; Male; Middle Aged; Poland; Risk Factors; Rural Population; Smoking; Urban Population; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2005 |
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in patients with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Polymorphism, Single Nucleotide; Reference Values; Vitamin B 12 | 2006 |
Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study.
Topics: Aged; Cohort Studies; Cystathionine beta-Synthase; Female; Folic Acid; Heterozygote; Homocysteine; Humans; Male; Methionine; Middle Aged; Minisatellite Repeats; Nuclear Family; Vitamin B 12; Vitamin B 6 | 2006 |
[Better prognosis for stroke patients].
Topics: Aged, 80 and over; Bias; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Myocardial Infarction; Randomized Controlled Trials as Topic; Stroke; Vitamin B 12; Vitamin B 6 | 2006 |
Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children.
Topics: Brazil; Child; Child, Preschool; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Multivariate Analysis; Polymorphism, Genetic; Reference Values; Risk Factors; Transcobalamins; Vitamin B 12 | 2007 |
Determinants of fasting total serum homocysteine levels in liver transplant recipients.
Topics: Adult; Aged; Fasting; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Liver Transplantation; Male; Middle Aged; Risk Factors | 2006 |
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltransferase; Blood Glucose; Diabetes Mellitus, Experimental; Diet; Folic Acid; Glycine N-Methyltransferase; Homocysteine; Liver; Male; Nutritional Status; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Weight Gain | 2006 |
Folic acid supplementation and methotrexate therapy for psoriasis.
Topics: Dermatologic Agents; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methotrexate; Psoriasis | 2006 |
Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring.
Topics: Adult; Case-Control Studies; Chromosome Aberrations; Down Syndrome; Female; Folic Acid; Gene Frequency; Genotype; Haplotypes; Homocysteine; Humans; Maternal Age; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Polymorphism, Genetic; Risk Factors | 2006 |
Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Arizona; Cardiovascular Diseases; Cause of Death; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid; Homocysteine; Humans; Indians, North American; Infections; Longitudinal Studies; Male; Middle Aged; Proportional Hazards Models; Serum Albumin; Vitamin B 12 | 2007 |
Folic acid inhibits homocysteine-induced superoxide anion production and nuclear factor kappa B activation in macrophages.
Topics: Cell Line; Chemokine CCL2; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Macrophages; NADPH Oxidases; NF-kappa B; RNA, Messenger; Superoxides | 2006 |
Homocysteine, folate and vitamin b12 in patients with coronary heart disease.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers; Chromatography, High Pressure Liquid; Coronary Disease; Creatinine; Diet; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Vitamin B 12; Vitamin B Complex | 2006 |
Plasma homocysteine as a metabolic risk factor for breast cancer: findings from a case-control study in Taiwan.
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Dietary Supplements; Female; Folic Acid; History, 16th Century; Homocysteine; Humans; Middle Aged; Risk Factors; Taiwan; Vitamin B Complex | 2007 |
Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia.
Topics: Cardiovascular Diseases; Catalase; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Oxidative Stress; Polysomnography; Postmenopause; Risk Factors; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin B 6 | 2006 |
[Homocysteine lowering with folic acid and B vitamins in vascular disease].
Topics: Aged; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome; Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2006 |
Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals.
Topics: Adipose Tissue; Adult; Body Composition; Body Water; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male; Menopause; Methionine; Middle Aged; Muscle, Skeletal; Risk Factors; Sex Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
G1793A polymorphisms in the methylene-tetrahydrofolate gene: effect of folic acid on homocysteine levels.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Folic Acid; Gene Frequency; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Vitamin B 12 | 2006 |
[The effect of lowering plasma homocysteine levels on some parameters of thrombotic activity in haemodialyzed patients with chronic renal failure].
Topics: Aged; Dose-Response Relationship, Drug; Female; Folic Acid; Hematologic Tests; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Reference Values; Renal Dialysis; Thrombosis; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2004 |
Alanine amino transferase concentrations are linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls.
Topics: Adolescent; Alanine Transaminase; Antioxidants; Aspartate Aminotransferases; Fatty Liver; Female; Folic Acid; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Liver; Methylenetetrahydrofolate Reductase (NADPH2); Obesity, Morbid; Polymorphism, Genetic; Surveys and Questionnaires; Vitamin B Complex | 2006 |
Nutritional determinants of plasma total homocysteine distribution in the Canary Islands.
Topics: Adolescent; Adult; Age Factors; Aged; Biomarkers; Cross-Sectional Studies; Diet; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male; Mental Recall; Middle Aged; Nutrition Surveys; Prevalence; Reference Values; Sex Factors; Spain; Surveys and Questionnaires; Vitamin B 12 | 2007 |
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Prospective Studies; Pyridoxal Phosphate; Valproic Acid; Vitamin B 12 | 2006 |
[Oral treatment of vitamin B12 deficiency in subacute combined degeneration].
Topics: Administration, Oral; Adult; Anemia, Pernicious; Autoantibodies; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Intrinsic Factor; Magnetic Resonance Imaging; Methylmalonic Acid; Neurologic Examination; Spinal Cord; Spinal Cord Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Plasma homocysteine and risk of coexisting silent brain infarction in Alzheimer's disease.
Topics: Aged; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Cell Death; Cerebral Infarction; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Genotype; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Neurons; Peptide Fragments; Risk Factors; tau Proteins; Vitamin B 12 | 2005 |
[Factors influencing homocysteineamia in type 2 diabetic patients].
Topics: Diabetes Mellitus, Type 2; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Obesity; Prospective Studies; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Plasma homocysteine, folate and vitamin B(12) compared between rural Gambian and UK adults.
Topics: Adult; Age Distribution; Black People; Female; Folic Acid; Gambia; Homocysteine; Humans; Lactation; Male; Middle Aged; Pregnancy; Rural Health; Sex Distribution; United Kingdom; Vitamin B 12; White People | 2006 |
Plasma homocysteine level and myocardial infarction: how high is high enough to need intervention?
Topics: Animals; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Myocardial Infarction; Prognosis; Risk Factors; Vitamin B Complex | 2006 |
[The treatment of hyperhomocysteinemia in patients on dialysis: folic acid or the high-flow polysulphonic membrane?].
Topics: Adult; Aged; Aged, 80 and over; Biocompatible Materials; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Membranes, Artificial; Middle Aged; Polymers; Renal Dialysis; Sulfones; Vitamin B Complex | 2006 |
Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients.
Topics: Adolescent; Adult; Aged; Blotting, Northern; Chi-Square Distribution; Child; Child, Preschool; DNA Mutational Analysis; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; India; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA, Messenger; Stroke; Vitamin B 12 | 2006 |
Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Prospective Studies; Risk Factors; Vitamin B 12 | 2007 |
Folic acid administration and antibodies against homocysteinylated proteins in subjects with hyperhomocysteinemia.
Topics: Alleles; Autoantibodies; Case-Control Studies; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Immunoglobulin G; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2006 |
Plasma homocysteine, cobalamin/folate status, and vascular disease in a large population of psychogeriatric patients.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Depressive Disorder; Female; Folic Acid; Hematocrit; Homocysteine; Humans; Male; Mental Disorders; Middle Aged; Nutritional Status; Population; Sweden; Vascular Diseases; Vitamin B 12 | 2006 |
The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea.
Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Creatine Kinase; Creatinine; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Isoenzymes; Korea; L-Lactate Dehydrogenase; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Natriuretic Peptide, Brain; Troponin I | 2006 |
Prospective evaluation of a peripherally administered three-in-one parenteral nutrition product in dogs.
Topics: Amino Acids; Animals; Catheterization, Peripheral; Dog Diseases; Dogs; Equipment Failure; Fat Emulsions, Intravenous; Female; Folic Acid; Food, Formulated; Homocysteine; Male; Parenteral Nutrition; Prospective Studies; Safety; Time Factors; Treatment Outcome; Vitamin B 12 | 2006 |
Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Apoptosis; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Intestinal Neoplasms; Male; Membrane Transport Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; Reduced Folate Carrier Protein | 2007 |
Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels.
Topics: 5' Flanking Region; Base Sequence; Erythrocytes; Exons; Folic Acid; Homocysteine; Humans; Introns; Molecular Sequence Data; Polymorphism, Single Nucleotide; Repetitive Sequences, Nucleic Acid; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2007 |
Patient information. The importance of homocysteine.
Topics: Biological Availability; Cardiovascular Diseases; Causality; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Nurse Practitioners; Risk Reduction Behavior; Tetrahydrofolates | 2006 |
Behavioural and psychological symptoms of Alzheimer type dementia are not correlated with plasma homocysteine concentration.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Folic Acid; Homocysteine; Humans; Male; Mental Disorders; Neuropsychological Tests; Psychological Tests; Severity of Illness Index; Vitamin B 12 | 2006 |
Nutritional status is altered in the self-neglecting elderly.
Topics: Aged; Aged, 80 and over; Aging; Bone and Bones; C-Reactive Protein; Calcifediol; Elder Abuse; Erythrocytes; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Iron; Male; Nutritional Status; Osteocalcin; Self Care; Sex Characteristics; Vitamin D; Vitamins | 2006 |
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
Topics: Betaine; Carbon; DNA Methylation; Folic Acid; Formate-Tetrahydrofolate Ligase; Homocysteine; Humans; Kinetics; Mathematics; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Molecular Biology; Nutritional Physiological Phenomena; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polymorphism, Genetic; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2006 |
Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
Topics: Adult; Cross-Sectional Studies; Dietary Supplements; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Male; Nutritional Status; Pregnancy; Prenatal Care; Social Class; Socioeconomic Factors; Vitamin B 12; Vitamin B Complex | 2007 |
Homocysteine, vitamin B12 and folate levels in premature coronary artery disease.
Topics: Adult; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Prevalence; Risk Factors; Sex Characteristics; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Homocysteine lowering and cognitive performance.
Topics: Aged; Cognition; Cognition Disorders; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B 12; Vitamin B Complex | 2006 |
Reference range of total serum homocysteine level and dietary indexes in healthy Greek schoolchildren aged 6-15 years.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Aging; Anthropometry; Blood Pressure; Body Mass Index; Child; Child Nutritional Physiological Phenomena; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Reference Values; Sex Characteristics; Vitamin B 12 | 2006 |
[Homocysteine as a cardiovascular marker and risk factor].
Topics: Cause of Death; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Myocardial Infarction; Risk Factors; Secondary Prevention; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2006 |
Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study.
Topics: Adolescent; Adult; Aged; Alleles; Bicycling; Black People; Body Height; Body Mass Index; Body Weight; Cotinine; Creatinine; Ethnicity; Exercise; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Oxygen; Physical Fitness; Sex Characteristics; Vitamin B 12; Vitamins; Waist-Hip Ratio; White People | 2006 |
Hyperhomocysteinemia is associated with deep venous thrombosis of the lower extremities in Tunisian patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Creatinine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Leg; Male; Middle Aged; Prevalence; Recurrence; Tunisia; Venous Thrombosis; Vitamin B 12 | 2007 |
Circulating homocysteine levels in patients with type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Folic Acid; Genotype; Glomerular Filtration Rate; Glycated Hemoglobin; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymorphism, Genetic; Up-Regulation; Vitamin B 12 | 2008 |
[Homocysteinemia and thrombophilic factors in unexplained decompression sickness].
Topics: Adult; Decompression Sickness; Diving; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Reference Values; Thrombophilia; Vitamin B 12 Deficiency | 2006 |
Tutorial in biostatistics: Analyzing associations between total plasma homocysteine and B vitamins using optimal categorization and segmented regression.
Topics: Algorithms; Canada; Data Interpretation, Statistical; Folic Acid; Homocysteine; Humans; Linear Models; Models, Statistical; Nutrition Surveys; Regression Analysis; Vitamin B 12; Vitamin B Complex | 2006 |
Association between the NAT1 1095C > A polymorphism and homocysteine concentration.
Topics: Adult; Alleles; Arylamine N-Acetyltransferase; Base Sequence; DNA Primers; Female; Folic Acid; Genotype; Homocysteine; Humans; Isoenzymes; Male; Polymorphism, Single Nucleotide; Smoking; Vitamin B 12 | 2006 |
Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss.
Topics: Abortion, Habitual; Adolescent; Adult; Aged; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors; Thrombosis; Vitamin B 12 | 2007 |
Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia.
Topics: Animals; Clotrimazole; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mesenteric Arteries; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Vasodilation; Vasodilator Agents | 2006 |
Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice.
Topics: Animals; DNA-Binding Proteins; Female; Folic Acid; Folic Acid Deficiency; Gene Expression Profiling; Homocysteine; Homozygote; Mice; Mice, Mutant Strains; Neural Tube Defects; Proto-Oncogene Proteins | 2006 |
[Increase of homocysteine in cardiovascular diseases in Hungary].
Topics: Adult; Aged; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; COUP Transcription Factor II; Diabetes Mellitus, Type 2; Factor XIII; Female; Folic Acid; Homocysteine; Humans; Hungary; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Patient Selection; Polymorphism, Genetic; Retrospective Studies; Risk Factors; Vitamin B 12 | 2006 |
Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats.
Topics: Animals; Corticosterone; Female; Folic Acid; Gonadal Steroid Hormones; Homocysteine; Lipid Peroxidation; Oxidative Stress; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Vitamin B 6 | 2006 |
Acute effect of smoking and of 2 weeks of folate substitution on hemostasis and homocysteine in healthy chronic smokers.
Topics: Atherosclerosis; Chronic Disease; Folic Acid; Hemostasis; Homocysteine; Inflammation; Smoking; Thrombosis; Time Factors; Vitamin B Complex | 2006 |
Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline.
Topics: Adaptation, Physiological; Animals; Area Under Curve; Arginine; Blood Pressure; Choline; Dietary Proteins; Dietary Supplements; Folic Acid; Homocysteine; Male; Methionine; Methylation; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Time Factors | 2006 |
Total homocysteine, folate, and cobalamin, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents.
Topics: Adolescent; Aging; Blood Pressure; Body Mass Index; Child; Child, Preschool; Cholesterol; Creatinine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Sex Characteristics; Triglycerides; Vitamin B 12 | 2006 |
Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Heart Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Maternal Age; Pregnancy; Pregnancy Complications; Risk Factors; Statistics, Nonparametric; Vitamin B 12 | 2006 |
Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway.
Topics: Adenoma; Aged; Biomarkers, Tumor; Carbon; Colorectal Neoplasms; Dietary Supplements; DNA Methylation; Female; Folic Acid; Genotype; Homeostasis; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Recurrence, Local; Polymorphism, Genetic; Prospective Studies; Risk Factors; Vitamins | 2006 |
Population reference values for plasma total homocysteine concentrations in US adults after the fortification of cereals with folic acid.
Topics: Adult; Age Distribution; Aged; Aging; Edible Grain; Female; Folic Acid; Food, Fortified; Hispanic or Latino; Homocysteine; Humans; Male; Mexican Americans; Middle Aged; Nutrition Surveys; Reference Values; Sex Distribution; White People | 2006 |
Plasma homocysteine and folate levels in patients with chronic plaque psoriasis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Chronic Disease; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Psoriasis | 2006 |
Homocysteine and bone loss in epilepsy.
Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticonvulsants; Blood Urea Nitrogen; Bone Density; Bone Diseases, Metabolic; Calcium; Epilepsy; Female; Folic Acid; Hip; Homocysteine; Humans; Male; Middle Aged; Osteoporosis; Regression Analysis; Spine | 2007 |
Functional inference of the methylenetetrahydrofolate reductase 677C > T and 1298A > C polymorphisms from a large-scale epidemiological study.
Topics: Adenine Nucleotides; Cytosine Nucleotides; Epidemiologic Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Thymine Nucleotides | 2007 |
The effect of two different doses comprising the simultaneous administration of intravenous B-complex vitamins and oral folic acid on serum homocysteine levels in hemodialysis patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Renal Dialysis; Vitamin B Complex | 2006 |
Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice.
Topics: Animals; Aorta; Apolipoproteins; Apolipoproteins E; Atherosclerosis; Dietary Supplements; Folic Acid; Homocysteine; Lipids; Liver; Male; Mice; Mice, Knockout; Oxidative Stress; Vitamin B Complex | 2007 |
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Valproic Acid; Vitamin B 12; Vitamin B 6 | 2007 |
Dietary intake of B-vitamins in mothers born a child with a congenital heart defect.
Topics: Adult; Case-Control Studies; Dietary Proteins; Educational Status; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Logistic Models; Maternal Nutritional Physiological Phenomena; Nutritional Requirements; Nutritional Status; Pregnancy; Pregnancy Complications; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B Complex | 2006 |
Consequences of subchronic and chronic exposure to intermittent hypoxia and sleep deprivation on cardiovascular risk factors in rats.
Topics: Animals; Blood Gas Analysis; Body Weight; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Chronic Disease; Cysteine; Folic Acid; Homocysteine; Hypoxia; Male; Rats; Rats, Wistar; Risk Factors; Sleep Apnea Syndromes; Sleep Deprivation; Sleep, REM; Triglycerides; Vitamin B 12 | 2007 |
13N-ammonia rest/stress PET: folic acid improves global coronary vasoreactivity in coronary artery disease patients with normal or elevated homocysteine levels.
Topics: Aged; Ammonia; Coronary Angiography; Coronary Disease; Exercise Test; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitrogen Radioisotopes; Positron-Emission Tomography; Reference Values | 2006 |
[Uncertain effects of folic acid on disorders other than neural-tube defects].
Topics: Animals; Cardiovascular Diseases; Dose-Response Relationship, Drug; Evidence-Based Medicine; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Randomized Controlled Trials as Topic; Time Factors | 2006 |
Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study.
Topics: Aged; Aged, 80 and over; Aging; China; Cognition; Female; Folic Acid; Homocysteine; Humans; Linear Models; Longitudinal Studies; Male; Middle Aged; Psychological Tests; Singapore; Vitamin B 12; Vitamin B Complex | 2006 |
Homocysteinylation of metallothionein impairs intracellular redox homeostasis: the enemy within!
Topics: Atherosclerosis; Betaine; Endothelium, Vascular; Folic Acid; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Metallothionein; Oxidation-Reduction; Risk Factors; Vitamin B Complex | 2007 |
Predictive factors of hyperhomocysteinemia in HIV-positive patients.
Topics: Adult; Antiretroviral Therapy, Highly Active; Cross-Sectional Studies; Female; Folic Acid; HIV Infections; HIV Seropositivity; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged | 2007 |
Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid.
Topics: Adult; Aged; Aging; Biomarkers; Cystathionine; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Transcobalamins; Vitamin B 12 | 2007 |
Summaries for patients. The effect of folic acid on hearing in older adults.
Topics: Aged; Aged, 80 and over; Aging; Auditory Threshold; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Hearing Loss, Sensorineural; Homocysteine; Humans; Male; Middle Aged | 2007 |
Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer.
Topics: Aged; Carboxypeptidases; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Stomach Neoplasms; Vitamin B 12 | 2007 |
Folic acid fortification: the good, the bad, and the puzzle of vitamin B-12.
Topics: Cognition Disorders; Dose-Response Relationship, Drug; Folic Acid; Food, Fortified; Homocysteine; Humans; Immune System; Neoplasms; Nutrition Policy; Vitamin B 12; Vitamin B Complex | 2007 |
Plasma B vitamins and their relation to the severity of chronic heart failure.
Topics: Aged; Cardiac Catheterization; Echocardiography; Female; Folic Acid; Folic Acid Deficiency; Heart Failure; Homocysteine; Humans; Liver; Male; Middle Aged; Multivariate Analysis; Severity of Illness Index; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2007 |
Hyperhomocysteinemia as a cardiovascular risk factor in Indian women: determinants and directionality.
Topics: Adult; Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Middle Aged; Risk Assessment; Risk Factors; Vitamin B 12 | 2006 |
Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly.
Topics: Aged; Avitaminosis; Biomarkers; Creatinine; Cystatin C; Cystatins; Female; Folic Acid; Folic Acid Deficiency; Glomerular Filtration Rate; Homocysteine; Humans; Kidney; Male; Methylmalonic Acid; Nutritional Status; Regression Analysis; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2007 |
I think I should take folic acid supplements to lower my risk of heart disease. A friend told me not to bother. Who's right?
Topics: Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Risk Factors | 2006 |
Homocysteine concentrations and molecular analysis in patients with congenital heart defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Carbon-Nitrogen Ligases; Child, Preschool; Cystathionine beta-Synthase; Female; Folic Acid; Gene Frequency; Heart Defects, Congenital; Homocysteine; Humans; Male; Mutation; Vitamin B 12 | 2007 |
B-group vitamins, MTHFR C677T polymorphism and carotid intima-media thickness in clinically healthy subjects.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Carbon-Nitrogen Ligases; Carotid Arteries; Carotid Artery Diseases; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Sex Factors; Tunica Intima; Vitamin B 12; Vitamin B Complex | 2007 |
Combinations of carbohydrate-deficient transferrin, mean corpuscular erythrocyte volume, gamma-glutamyltransferase, homocysteine and folate increase the significance of biological markers in alcohol dependent patients.
Topics: Adult; Aged; Alcoholism; Biomarkers; Erythrocyte Indices; Female; Folic Acid; gamma-Glutamyltransferase; Homocysteine; Humans; Male; Middle Aged; Predictive Value of Tests; Reference Values; Sensitivity and Specificity; Sex Factors; Transferrin | 2007 |
New insights into the regulation of methyl group and homocysteine metabolism.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Folic Acid; Glycine N-Methyltransferase; Homocysteine; Humans; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylmethionine | 2007 |
High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status.
Topics: Adult; China; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Odds Ratio; Prevalence; Risk Factors; Seasons; Vitamin B 12; Vitamin B 6 | 2007 |
Is dietary intake of folate too low?
Topics: Aged; Cognition Disorders; Diet; Folic Acid; Folic Acid Deficiency; Food Analysis; Homocysteine; Humans; Middle Aged; Nutrition Policy; Nutritional Status; Randomized Controlled Trials as Topic | 2007 |
Association of methylenetetrahydrofolate (MTHFR) and apolipoprotein E (apo E) genotypes with homocysteine, vitamin and lipid levels in carotid stenosis.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Apolipoproteins E; Carotid Stenosis; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Middle Aged; Mutation; Vitamin B 12 | 2006 |
Hyperhomocysteinaemia and immune activation in patients with cancer.
Topics: Aged; Biomarkers; Case-Control Studies; Cysteine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immune System; Male; Neoplasms; Neopterin; Vitamin B 12 | 2007 |
The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Chemokine CCL2; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Inflammation; Interleukin-6; Interleukin-8; Male; Middle Aged; Vitamin B 12; Vitamin B 6 | 2007 |
Elevated serum homocysteine, low serum vitamin B12, folate, and age-related macular degeneration: the Blue Mountains Eye Study.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Macular Degeneration; Male; Middle Aged; New South Wales; Odds Ratio; Risk Factors; Vitamin B 12 | 2007 |
Plasma homocysteine levels in female patients with eating disorders.
Topics: Adolescent; Adult; Bone Density; Feeding and Eating Disorders; Female; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2007 |
Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.
Topics: Adult; Catechol O-Methyltransferase; Cohort Studies; Coronary Disease; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Polymorphism, Genetic; Prospective Studies; Risk Factors | 2007 |
Altered renal folate handling in hypertensive patients with nephroangiosclerotic damage.
Topics: Case-Control Studies; Creatinine; Folic Acid; Genotype; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension, Renal; Ischemia; Methylenetetrahydrofolate Reductase (NADPH2); Nephrons; Renal Artery Obstruction; Vitamin B 12 | 2007 |
Abnormalities of homocysteine and B vitamins in the nephrotic syndrome.
Topics: Adult; Antibodies, Antiphospholipid; Antithrombins; Factor V; Female; Folic Acid; Homocysteine; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Nephrotic Syndrome; Risk; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Base Sequence; Case-Control Studies; CpG Islands; Deoxyguanosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; DNA, Mitochondrial; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Glutathione Transferase; Homocysteine; Humans; India; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Sequence Deletion; Vitamin B 12; White People | 2007 |
Cardiovascular fitness is negatively associated with homocysteine levels in female adolescents.
Topics: Adolescent; Cardiovascular Physiological Phenomena; Exercise Test; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Physical Fitness; Polymorphism, Genetic; Regression Analysis; Sex Distribution; Sex Factors; Spain; Vitamin B 12 | 2007 |
Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->t genotypes and B-vitamin status in a large-scale epidemiological study.
Topics: Betaine; Choline; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamins | 2007 |
Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging.
Topics: Aged; Aged, 80 and over; Aging; California; Cognition Disorders; Dementia; Disease Susceptibility; Female; Folic Acid; Health Surveys; Hispanic or Latino; Homocysteine; Humans; Incidence; Male; Middle Aged; Risk Factors; Stroke; Vitamin B 12 | 2007 |
[In patients with coronary artery disease and left ventricular contractile insufficiency the pathogenicity of smoking associates with imbalance in metabolism of homocysteine].
Topics: Adult; Comorbidity; Coronary Angiography; Coronary Artery Disease; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Smoking; Stroke Volume; Ventricular Dysfunction, Left | 2006 |
The influence of fruit and vegetable intake on the nutritional status and plasma homocysteine levels of institutionalised elderly people.
Topics: Aged; Aged, 80 and over; Anthropometry; Cross-Sectional Studies; Diet Records; Diet Surveys; Erythrocytes; Female; Folic Acid; Fruit; Geriatric Assessment; Health Surveys; Homes for the Aged; Homocysteine; Humans; Male; Minerals; Nutrition Policy; Nutritional Requirements; Nutritional Status; Spain; Vegetables; Vitamins | 2007 |
Folic acid: a supplementary question.
Topics: Aged; Cognition; Dietary Supplements; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic | 2007 |
Associations between folate, vitamin B12, homocysteine and pathologies related to aging: the need to consider complex nutrient-nutrient and gene-nutrient interactions and the functional and socio-economic determinants in population-based studies.
Topics: Aging; Epidemiology; Folic Acid; Food; Genes; Homocysteine; Humans; Socioeconomic Factors; Vitamin B 12 | 2007 |
Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily.
Topics: Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Diabetes Mellitus; Folic Acid; Homocysteine; Humans; Middle Aged; Neoplasms; Peripheral Vascular Diseases; Sicily; Stroke; Vitamin B 12 | 2007 |
Association of thyroid dysfunction with vitamin B12, folate and plasma homocysteine levels in the elderly: a population-based study in Sicily.
Topics: Aged; Aged, 80 and over; Aging; Epidemiology; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Sicily; Thyroid Diseases; Vitamin B 12 | 2007 |
Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults.
Topics: Adolescent; Adult; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Carotid Arteries; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Japan; Regression Analysis; Risk Factors; Tunica Intima | 2007 |
Correlation of folate, vitamin B12 and homocysteine plasma levels with depression in an elderly Greek population.
Topics: Aged; Depression; Female; Folic Acid; Greece; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2007 |
Maternal vitamin B12 and the risk of fetal neural tube defects in Egyptian patients.
Topics: Case-Control Studies; Egypt; Female; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Neural Tube Defects; Odds Ratio; Pregnancy; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Antihypertensive Agents; Biopterins; Blood Pressure; Body Weight; Dexamethasone; Disease Models, Animal; F2-Isoprostanes; Folic Acid; Glucocorticoids; Homocysteine; Hypertension; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Thymus Gland; Time Factors | 2007 |
Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women.
Topics: Cardiovascular Diseases; Data Interpretation, Statistical; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genotype; Homocysteine; Humans; Incidence; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Prospective Studies; Risk Factors; Vitamin B Complex | 2007 |
Serum homocysteine, folate, vitamin B12 and total antioxidant status in vegetarian children.
Topics: Antioxidants; Child; Child, Preschool; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Male; Nutrition Policy; Nutritional Status; Vitamin B 12 | 2006 |
[The pathogenic mechanism of homocysteine -induced endothelial nitric oxide synthase dysfunction and the antagonistic effects by folic acid].
Topics: Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Immunohistochemistry; Nitric Oxide Synthase Type III; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Homocysteine increases the risk of mortality in elderly individuals.
Topics: Aged; Aging; Biomarkers; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Mortality; Selenium; Spain; Survival Analysis; Vitamin B 12 | 2007 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Elevated total homocysteine is associated with increased platelet activation at the site of microvascular injury: effects of folic acid administration.
Topics: Blood Vessels; Folic Acid; Homocysteine; Humans; Male; Platelet Activation | 2007 |
Folate status and risk of colorectal polyps in African Americans.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Black or African American; Case-Control Studies; Colonic Polyps; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Genes, APC; Homocysteine; Humans; Male; Middle Aged; Promoter Regions, Genetic; Smoking; Tetrahydrofolates; Vitamin B 12; Vitamins | 2007 |
Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women.
Topics: Aged; Betaine; Cardiovascular Diseases; Choline; Cohort Studies; Diet; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Middle Aged; Netherlands; Nutrition Surveys; Odds Ratio; Postmenopause; Prospective Studies; Surveys and Questionnaires | 2008 |
Folate status and S-adenosylmethionine/S-adenosylhomocysteine ratio in colorectal adenocarcinoma in humans.
Topics: Adenocarcinoma; Aged; Colon; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Male; Nutritional Status; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption.
Topics: Abruptio Placentae; Adolescent; Adult; Betaine-Homocysteine S-Methyltransferase; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Polymorphism, Genetic; Pregnancy; Risk Factors; Vitamin B 12 | 2007 |
Hyperhomocysteinemia and low methionine stress are risk factors for central retinal venous occlusion in an Indian population.
Topics: Adult; Case-Control Studies; Cysteine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Methionine; Prevalence; Prospective Studies; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2007 |
Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study.
Topics: Aged; Cohort Studies; Diet Surveys; Dietary Carbohydrates; Dietary Supplements; Feeding Behavior; Female; Folic Acid; Fruit; Homocysteine; Humans; Male; Meat; Micronutrients; Middle Aged; Norway; Sex Distribution; Surveys and Questionnaires; Vegetables; Vitamin B Complex; Vitamins | 2007 |
No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese.
Topics: Adult; Aged; Atherosclerosis; Atrophy; Female; Folic Acid; Gastric Mucosa; Genotype; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Smoking | 2007 |
Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study.
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Case-Control Studies; Creatinine; DNA Mutational Analysis; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Retrospective Studies; Risk Assessment; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B 6 Deficiency | 2007 |
Acute effects of tea on fasting and non-fasting plasma total homocysteine concentrations in human subjects.
Topics: Aged; Biomarkers; Caffeine; Cross-Over Studies; Drinking; Eating; Fasting; Female; Flavonoids; Folic Acid; Gallic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Phenols; Polyphenols; Tea; Vitamin B 12 | 2007 |
MTHFR Gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients.
Topics: Adult; Age Factors; Diet; Dietary Supplements; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Polymorphism, Single Nucleotide; Riboflavin; Vitamin B 12; Vitamin B Complex | 2007 |
Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects.
Topics: Betaine; Dietary Supplements; Folic Acid; Homocysteine; Homocystinuria; Humans; Methionine; Methylation; Neural Tube Defects; Nutritional Physiological Phenomena; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2007 |
Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats.
Topics: Animals; Biomarkers; Dietary Supplements; DNA Methylation; Folic Acid; Homocysteine; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamins; Weaning | 2007 |
Folic acid supplementation and cardiovascular diseases.
Topics: Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Risk; Vitamin B Complex | 2007 |
The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men.
Topics: Adult; Folic Acid; Homocysteine; Humans; Japan; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nicotinamide N-Methyltransferase; Polymorphism, Genetic; Risk Factors | 2007 |
The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism.
Topics: Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Riboflavin; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis
Topics: Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hydroxymethyl and Formyl Transferases; Membrane Transport Proteins; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Genetic; Reduced Folate Carrier Protein; Thymidylate Synthase; Venous Thrombosis | 2007 |
[Correlation between serum homocysteine levels and selected atherosclerosis risk factors in children and adolescents with simple obesity].
Topics: Adolescent; Atherosclerosis; Biomarkers; Body Mass Index; Child; Comorbidity; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hypertension; Male; Obesity; Obesity, Morbid; Poland; Risk Factors; Statistics, Nonparametric; Vitamin B 12 | 2006 |
Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?
Topics: Biomarkers; Cardiovascular Diseases; Chronic Disease; DNA Methylation; DNA-Cytosine Methylases; Epigenesis, Genetic; Female; Folic Acid; Homocysteine; Humans; Inflammation; Kidney Diseases; Male; Middle Aged; Oxidative Stress; Reproducibility of Results; Risk Factors | 2007 |
The association of homocysteine and related factors to brachial artery diameter and flow-mediated dilation.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Brachial Artery; Cardiovascular Diseases; Dilatation, Pathologic; DNA; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Point Mutation; Polymerase Chain Reaction; Ultrasonography; Vitamin B 12; Vitamin B 6 | 2007 |
Folic acid and B vitamins improve hyperhomocysteinemia-induced cardiovascular risk profile in renal transplant recipients.
Topics: Adult; Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Kidney Transplantation; Male; Middle Aged; Risk Factors; Vitamin B Complex | 2007 |
Homocysteine and cardiovascular risk: considering the evidence in the context of study design, folate fortification, and statistical power.
Topics: Cardiovascular Diseases; Data Interpretation, Statistical; Dietary Supplements; Epidemiologic Methods; Evidence-Based Medicine; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Prospective Studies; Research Design; Risk Factors; Twin Studies as Topic; Vitamin B Complex | 2007 |
Preconception B-vitamin and homocysteine status, conception, and early pregnancy loss.
Topics: Abortion, Spontaneous; Adult; China; Chorionic Gonadotropin; Female; Fertilization; Folic Acid; Homocysteine; Humans; Odds Ratio; Preconception Care; Pregnancy; Prospective Studies; Risk Assessment; Risk Factors; Vitamin B 12; Vitamin B 6 | 2007 |
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells.
Topics: Cell Line, Tumor; Cytoplasm; Dose-Response Relationship, Drug; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Kinetics; Mitochondria; Protein Isoforms; Pyridoxine; S-Adenosylmethionine; Vitamin B 6 | 2007 |
Short-term hyperhomocysteinemia-induced oxidative stress activates retinal glial cells and increases vascular endothelial growth factor expression in rat retina.
Topics: alpha-Tocopherol; Animals; Folic Acid; Glial Fibrillary Acidic Protein; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Male; Neuroglia; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Retina; Scavenger Receptors, Class E; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Vascular Endothelial Growth Factor A; Vimentin; Vitamin A | 2007 |
Neuropsychological correlates of homocysteine levels in euthymic bipolar patients.
Topics: Adolescent; Adult; Bipolar Disorder; Cognition; Cognition Disorders; Dysthymic Disorder; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Severity of Illness Index; Vitamin B 12 | 2008 |
Folate status in women of childbearing age with epilepsy.
Topics: Adolescent; Adult; Chi-Square Distribution; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Pregnancy; Surveys and Questionnaires | 2007 |
Validation of a food frequency questionnaire to assess folate intake of Dutch elderly people.
Topics: Aged; Biomarkers; Erythrocytes; Feeding Behavior; Female; Folic Acid; Homocysteine; Humans; Male; Netherlands; Nutrition Assessment; Reproducibility of Results; Surveys and Questionnaires | 2007 |
Beer ethanol consumption and plasma homocysteine among patients with type 2 diabetes.
Topics: Alcohol Drinking; Beer; Diabetes Mellitus, Type 2; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Regression Analysis; Vitamin B 12 | 2007 |
Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Analysis of Variance; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Young Adult | 2008 |
Relations between homocysteine, folate and vitamin B12 in vascular dementia and in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dementia, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Risk Factors; Vitamin B 12 | 2007 |
Secondary palatal closure in rats in association with relative maternofetal levels of folic acid, vitamin B12, and homocysteine.
Topics: Animals; Embryonic Development; Female; Folic Acid; Homocysteine; Maternal-Fetal Exchange; Palate; Pregnancy; Rats; Rats, Inbred Lew; Vitamin B 12 | 2007 |
Dietary intake of B(6-9-12) vitamins, serum homocysteine levels and their association with depressive symptoms: the Zutphen Elderly Study.
Topics: Aged; Aged, 80 and over; Depression; Diet; Folic Acid; Homocysteine; Humans; Linear Models; Logistic Models; Male; Nutritional Requirements; Nutritional Status; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2008 |
Priorities in the discovery of the implications of water channels in epilepsy and Duchenne muscular dystrophy.
Topics: Aquaporins; Brain; Epilepsy; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Muscular Dystrophy, Duchenne; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Lowering homocysteine for stroke prevention.
Topics: Folic Acid; Homocysteine; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Stroke; Vitamin B Complex | 2007 |
Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts.
Topics: Adult; Case-Control Studies; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pancreatic Neoplasms; Risk Factors; Vitamin B 12; Vitamin B 6 | 2007 |
Can B vitamin therapy help to prevent future vascular events?
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12 | 2007 |
Red cell folate and plasma homocysteine in preterm infants.
Topics: Brain Diseases; Dietary Supplements; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Infant Formula; Infant, Newborn; Infant, Premature; Male; Milk, Human; Pregnancy | 2007 |
Antiepileptic drugs and MTHFR polymorphisms influence hyper-homocysteinemia recurrence in epileptic patients.
Topics: Adult; Age Factors; Anticonvulsants; Combined Modality Therapy; Epilepsy; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Longitudinal Studies; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Recurrence; Substance Withdrawal Syndrome; Treatment Outcome | 2007 |
Folate status and mood: is there a relationship?
Topics: Adult; Affect; Erythrocytes; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Nutritional Physiological Phenomena; Nutritional Status; Psychiatric Status Rating Scales | 2008 |
Homocysteine and fibrinogen changes with L-thyroxine in subclinical hypothyroid patients.
Topics: Adult; Case-Control Studies; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Hypothyroidism; Kidney; Middle Aged; Thyrotropin; Thyroxine; Triiodothyronine; Vitamin B 12 | 2007 |
Mild hyperhomocysteinemia and low folate concentrations as risk factors for cervical arterial dissection.
Topics: Adolescent; Adult; Carotid Artery, Internal, Dissection; Case-Control Studies; Cerebral Arteries; Cerebral Infarction; Fasting; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Nutritional Status; Odds Ratio; Polymorphism, Genetic; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Vertebral Artery Dissection; Vitamin B 12 | 2007 |
Lowering homocysteine decreases levels and expression of VEGF(165) and endostatin.
Topics: Adult; Diabetes Mellitus; Down-Regulation; Endostatins; Female; Folic Acid; Gene Expression; Homocysteine; Humans; Leukocytes; Male; Middle Aged; Neovascularization, Pathologic; Peripheral Vascular Diseases; Reverse Transcriptase Polymerase Chain Reaction; Thiamine; Vascular Endothelial Growth Factor A; Vitamin B Complex | 2008 |
Plasma homocysteine, folate and B12 in chronic schizophrenia.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Chi-Square Distribution; Chronic Disease; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Schizophrenia; Sex Factors; Vitamin B 12 | 2007 |
Reference intervals for haematological variables during normal pregnancy and postpartum in 434 healthy Danish women.
Topics: Creatinine; Denmark; Female; Ferritins; Folic Acid; Hematologic Tests; Homocysteine; Humans; Methylmalonic Acid; Postpartum Period; Pregnancy; Receptors, Transferrin; Reference Values; Vitamin B 12 | 2007 |
Hyperhomocysteinemia in winter elite athletes: a longitudinal study.
Topics: Adult; Cardiovascular Diseases; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Longitudinal Studies; Male; Methylenetetrahydrofolate Reductase (NADPH2); Physical Exertion; Prevalence; Risk Factors; Seasons; Sex Distribution; Sports | 2007 |
Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Adenine Nucleotides; Animals; Blood Pressure; Collagen; Creatine; Dietary Supplements; Folic Acid; Heart Ventricles; Homocysteine; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardial Contraction; Random Allocation; Rats; Rats, Wistar; Ventricular Function, Left; Ventricular Function, Right | 2007 |
Influence of different dietary levels of zinc on performance, vitamin B12, and blood parameters in lambs.
Topics: Animal Feed; Animals; Blood Glucose; Body Weight; Cobalt; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Methylmalonic Acid; Rumen; Sheep; Vitamin B 12; Zinc | 2006 |
Folate, but not vitamin B-12 status, predicts respiratory morbidity in north Indian children.
Topics: Acute Disease; Child, Preschool; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Incidence; India; Infant; Male; Methylmalonic Acid; Multivariate Analysis; Prospective Studies; Regression Analysis; Respiratory Tract Infections; Risk Factors; Vitamin B 12 | 2007 |
Plasma pyridoxal-5-phosphate and future risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition Potsdam cohort.
Topics: Adult; Aged; Blood Pressure; Body Mass Index; C-Reactive Protein; Case-Control Studies; Cholesterol, HDL; Cohort Studies; Creatinine; Female; Folic Acid; Germany; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Prospective Studies; Pyridoxal Phosphate; Surveys and Questionnaires | 2007 |
Relationship between dietary folate intakes, maternal plasma total homocysteine and B-vitamins during pregnancy and fetal growth in Japan.
Topics: Adult; Biomarkers; Birth Weight; Body Mass Index; Erythrocytes; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Infant, Newborn; Japan; Male; Nutritional Status; Parity; Pregnancy; Pregnancy Outcome; Vitamin B 12; Vitamin B Complex | 2007 |
Correlations between folate, B12, homocysteine levels, and radiological markers of neuropathology in elderly post-stroke patients.
Topics: Aged; Biomarkers; Brain; Brain Infarction; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Magnetic Resonance Imaging; Male; Mental Recall; Nutrition Assessment; Nutrition Policy; Stroke; Surveys and Questionnaires; Vitamin B 12; Vitamin B Complex | 2007 |
The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aged; Diseases in Twins; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Ischemia; Polymorphism, Single Nucleotide; Surveys and Questionnaires; Vitamin B 12 | 2007 |
Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis.
Topics: Aged; Aged, 80 and over; Aging; Creatinine; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Kidney Function Tests; Male; Mental Disorders; Psychiatric Status Rating Scales; Vascular Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
Does lowering hyperhomocysteinemia by folic acid beneficial for oculo-Behcet's disease? A pilot study.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Behcet Syndrome; Cyclophosphamide; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Male; Middle Aged; Pilot Projects; Prospective Studies; Retinal Vasculitis; Uveitis; Visual Acuity; Vitamin B Complex | 2007 |
Elevated homocysteine levels in patients with slow coronary flow: relationship with Helicobacter pylori infection.
Topics: Adult; Blood Flow Velocity; Cardiovascular Diseases; Coronary Circulation; Female; Folic Acid; Helicobacter Infections; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2007 |
Accumulation of homocysteine by decreasing concentrations of folate, vitamin B12 and B6 does not influence the activity of human osteoblasts in vitro.
Topics: Calcification, Physiologic; Cells, Cultured; Folic Acid; Homocysteine; Humans; Osteoblasts; Osteocalcin; Peptide Fragments; Procollagen; Vitamin B 12; Vitamin B 6 | 2007 |
Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study.
Topics: Alcohol Drinking; Animals; Antigens, Surface; Anxiety; Cardiovascular Diseases; Cognition; Depression; DNA; DNA Primers; Exons; Female; Folic Acid; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Linkage Disequilibrium; Male; Norway; Polymorphism, Genetic; Temperance | 2007 |
B-vitamins and homocysteine in Spanish institutionalized elderly.
Topics: Aged; Aged, 80 and over; Aging; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Institutionalization; Male; Middle Aged; Regression Analysis; Sex Characteristics; Spain; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamin B Deficiency | 2007 |
Folate: in vitro and in vivo effects on VLDL and LDL oxidation.
Topics: Antioxidants; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lipid Peroxidation; Lipoproteins, LDL; Lipoproteins, VLDL; Oxidation-Reduction; Tetrahydrofolates | 2007 |
Homocysteine-lowering vitamins and cardiovascular mortality: are they really effective?
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Vitamins | 2008 |
[Vitamin B12 therapy: oral or intramuscular].
Topics: Administration, Oral; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Injections, Intramuscular; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
Homocysteine, folic acid and vitamin B12 concentration in patients with recurrent miscarriages.
Topics: Abortion, Habitual; Adult; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Vitamin B 12 | 2007 |
Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Micronuclei, Chromosome-Defective; Middle Aged; Mothers; Polymorphism, Genetic | 2007 |
A ferritin-responsive internal ribosome entry site regulates folate metabolism.
Topics: 5' Untranslated Regions; Apoferritins; CELF1 Protein; Cell Line, Tumor; DNA, Complementary; Folic Acid; Gene Deletion; Genes; HeLa Cells; Homocysteine; Humans; Models, Biological; Ribosomes; RNA-Binding Proteins; RNA, Small Interfering; Two-Hybrid System Techniques | 2007 |
[Effects of folic acid, vitamin B(6) and vitamin B(12) on learning and memory function in cerebral ischemia rats].
Topics: Animals; Brain Ischemia; Disease Models, Animal; Female; Folic Acid; Homocysteine; Infarction, Middle Cerebral Artery; Learning; Male; Memory; Rats; Rats, Sprague-Dawley; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Changes in mitochondrial DNA deletion, content, and biogenesis in folate-deficient tissues of young rats depend on mitochondrial folate and oxidative DNA injuries.
Topics: Aging; Animals; DNA Damage; DNA, Mitochondrial; Folic Acid; Gene Deletion; Homocysteine; Mitochondria; Oxidation-Reduction; Rats; Rats, Wistar; RNA, Messenger | 2007 |
Homocysteine (Hcy) follow-up study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Coronary Artery Disease; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B Complex | 2007 |
[Antibodies to N-homocysteinylated albumin in patients with systemic lupus erythematosus].
Topics: Adolescent; Adult; Autoantibodies; C-Reactive Protein; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Serum Albumin; Vitamin B 12 | 2007 |
Effects of white European, African Caribbean and South Asian ethnicity on homocysteine levels in patients with systolic heart failure.
Topics: Aged; Asia, Southeastern; Asian People; Black People; Ethnicity; Female; Folic Acid; Heart Failure, Systolic; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; West Indies; White People | 2008 |
Folic acid for stroke prevention.
Topics: Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Research Design; Risk; Stroke; Vitamin B Complex | 2007 |
Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele.
Topics: Aged; Alleles; Bone Density; Cohort Studies; Female; Folic Acid; Folic Acid Deficiency; Fractures, Bone; Genotype; Homocysteine; Humans; Incidence; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osteoporosis, Postmenopausal; Postmenopause; Riboflavin; Riboflavin Deficiency; Risk Factors | 2008 |
Influence of preconditioning-like hypoxia on the liver of developing methyl-deficient rats.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Choline Deficiency; Cystathionine beta-Synthase; Female; Folic Acid; Folic Acid Deficiency; Food, Formulated; Glutathione; Homocysteine; Hypoxia; Liver; Nitric Oxide Synthase Type II; Pregnancy; Rats; Rats, Wistar; Riboflavin; Riboflavin Deficiency; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Deficiency | 2007 |
Folate and ApoE DNA methylation induced by homocysteine in human monocytes.
Topics: Apolipoproteins E; Cells, Cultured; Cholesterol; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Foam Cells; Folic Acid; Homocysteine; Humans; Lipid Metabolism; Monocytes; Promoter Regions, Genetic | 2007 |
Marfanoid features in a child with combined methylmalonic aciduria and homocystinuria (CblC type).
Topics: Adolescent; Carnitine; Carrier Proteins; Child; Cysteine; Diagnosis, Differential; DNA Mutational Analysis; Exons; Female; Folic Acid; Genetic Testing; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Marfan Syndrome; Metabolism, Inborn Errors; Methylmalonic Acid; Mutation; Oxidoreductases; Pedigree; Phenotype; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamins | 2007 |
Plasma folate concentration and cognitive performance: Rotterdam Scan Study.
Topics: Aged; Aged, 80 and over; Aging; Brain; Cognition; Confidence Intervals; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Multivariate Analysis; Netherlands; Odds Ratio; Prospective Studies; Psychomotor Performance | 2007 |
[Serum homocysteine, folate and vitamin B12 in venezuelan elderly].
Topics: Aged; Aged, 80 and over; Body Mass Index; Energy Intake; Female; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemoglobins; Homocysteine; Humans; Male; Middle Aged; Reference Values; Venezuela; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Antioxidants; Aspartic Acid Endopeptidases; Blotting, Western; Cell Line, Tumor; DNA Methylation; DNA Primers; Folic Acid; Glioblastoma; Homocysteine; Humans; Neuroblastoma; Oxidative Stress; Polymerase Chain Reaction; Presenilin-1; S-Adenosylmethionine; Up-Regulation; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2007 |
Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Diet; Europe; Folic Acid; Homocysteine; Humans; Middle Aged; Nutritional Requirements; Vitamin B 12; Young Adult | 2009 |
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study.
Topics: Adipose Tissue; Anthropometry; Body Composition; Body Mass Index; Child; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; Male; Methylmalonic Acid; Pregnancy; Pregnancy Complications; Vitamin B 12 | 2008 |
Experimental hyperhomocysteinemia disturbs bone metabolism in rats.
Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Collagen Type I; Creatine; Female; Folic Acid; Homocysteine; Hydroxyproline; Hyperhomocysteinemia; Methionine; Osteocalcin; Osteogenesis; Peptides; Rats; Rats, Wistar; Vitamin B 12 | 2007 |
Homocysteine, folate and vitamin B12 in Colombian patients with coronary disease.
Topics: Acute Coronary Syndrome; Adult; Biomarkers; Colombia; Epidemiologic Methods; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Middle Aged; Vitamin B 12 | 2007 |
Homocysteine and diabetic retinopathy.
Topics: Adult; Aged; Biomarkers; Blood Pressure; Cross-Sectional Studies; Diabetic Retinopathy; Female; Fluorescein Angiography; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Life Style; Male; Middle Aged; Odds Ratio; Risk Factors | 2008 |
Homocysteine in restless legs syndrome.
Topics: Aged; Antiparkinson Agents; Catechols; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Reference Values; Restless Legs Syndrome; Vitamin B 12; Vitamin B 6 | 2008 |
Plasma creatinine as a determinant of plasma total homocysteine concentrations in the Hordaland Homocysteine Study: use of statistical modeling to determine reference limits.
Topics: Adult; Age Factors; Aged; Creatinine; Female; Folic Acid; Homocysteine; Humans; Kidney Function Tests; Male; Middle Aged; Models, Statistical; Sex Factors; Vitamin B 12 | 2007 |
Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption.
Topics: Abruptio Placentae; Adolescent; Adult; Alleles; Case-Control Studies; DNA; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Social Class; Vitamin B 12 | 2007 |
Mutations in exons 2 and 3 of the FOLR1 gene in demented and non-demented elderly subjects.
Topics: Aged; Base Sequence; Carrier Proteins; Dementia; DNA Mutational Analysis; Exons; Female; Folate Receptor 1; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Testing; Homocysteine; Humans; Male; Molecular Sequence Data; Mutation; Polymorphism, Single Nucleotide; Receptors, Cell Surface | 2007 |
Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients.
Topics: Aged; Antiparkinson Agents; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Polymorphism, Genetic; Vitamin B 12 | 2007 |
Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia.
Topics: Adaptor Proteins, Signal Transducing; Adenoma; Aged; Base Sequence; Biomarkers; Case-Control Studies; Colon; Colonic Polyps; Colorectal Neoplasms; DNA Methylation; Erythrocytes; Estrogen Receptor alpha; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Male; Middle Aged; MutL Protein Homolog 1; Nuclear Proteins; Nutritional Status; Vitamin B 12 | 2007 |
The association between betaine and choline intakes and the plasma concentrations of homocysteine in women.
Topics: Adult; Alcohol Drinking; Betaine; Biomarkers; Choline; Cross-Sectional Studies; Diet Records; Female; Folic Acid; Homocysteine; Humans; Linear Models; Lipotropic Agents; Methylation; Middle Aged; Predictive Value of Tests; Surveys and Questionnaires; Vitamin B Complex | 2007 |
[The relationship between polymorphism of gene involved in folate metabolism, homocysteine level and risk of Down syndrome].
Topics: Adult; Alleles; Base Sequence; Case-Control Studies; Down Syndrome; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Pregnancy | 2007 |
Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans.
Topics: Adult; Dietary Supplements; Female; Fertilization in Vitro; Folic Acid; Follicular Fluid; Homocysteine; Humans; Oocyte Retrieval; Oocytes; Ovarian Follicle; Sperm Injections, Intracytoplasmic | 2008 |
Low folate status enhanced benzene-induced cytogenetic damage in bone marrow of mice: a relationship between dietary intake and tissue levels of folate.
Topics: Administration, Oral; Animals; Benzene; Bone Marrow Cells; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Erythrocytes; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Mice; Micronucleus Tests; Random Allocation; Vitamin B Complex | 2007 |
Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin.
Topics: Animals; Arsenites; Binding Sites; Carcinogens, Environmental; Cell Differentiation; Cell Proliferation; Epidermis; Female; Folic Acid; Folic Acid Deficiency; Gene Expression; Gene Expression Profiling; Homocysteine; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Skin; Skin Neoplasms; Sodium Compounds; Transcription Factors | 2007 |
Methylenetetrahydrofolate reductase gene and risk of Alzheimer's disease in Koreans.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Asian People; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors; Vitamin B 12 | 2008 |
Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs.
Topics: Adult; Arsenic; Arsenic Poisoning; Bangladesh; Biomarkers; Cohort Studies; Environmental Exposure; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Vitamin B 12; Water Supply | 2007 |
Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Radioimmunoassay; Retinal Vein Occlusion; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B 6 Deficiency | 2008 |
Acute effects of haemodialysis on biochemical modulators of endothelial function.
Topics: Arginine; Blood Pressure; C-Reactive Protein; Endothelium, Vascular; Female; Folic Acid; Heart Rate; Homocysteine; Humans; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Renal Dialysis; Vasodilation | 2007 |
Impaired vitamin B12 metabolic status in healthcare workers occupationally exposed to nitrous oxide.
Topics: Adult; Anesthetics, Inhalation; Blood Specimen Collection; Dose-Response Relationship, Drug; Environmental Monitoring; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Nitrous Oxide; Occupational Exposure; Operating Room Nursing; Operating Rooms; Ventilation; Vitamin B 12 | 2007 |
Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine are associated with retinal microvascular abnormalities: the Hoorn Study.
Topics: Aged; Aged, 80 and over; Arterioles; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Folic Acid; Follow-Up Studies; Glucose Tolerance Test; Homocysteine; Humans; Male; Middle Aged; Retinal Diseases; Retinal Vessels; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytochromes b5; Disease Models, Animal; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Hepatocytes; Homocysteine; Male; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6; Vitamin B Complex | 2007 |
Enhancing recruitment of healthy African American volunteers in a city with a small African American community: results from a dietary supplement crossover trial.
Topics: Adolescent; Adult; Aged; Black or African American; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Patient Selection; Washington | 2007 |
Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Neural Tube Defects; Nutrition Policy; Nutritional Status; Vitamin B 12; Vitamin B 6 | 2007 |
Association of blood pressure, obesity and serum homocysteine levels in healthy children.
Topics: Adolescent; Age Factors; Analysis of Variance; Blood Pressure; Body Mass Index; Child; Energy Intake; Female; Folic Acid; Greece; Homocysteine; Humans; Male; Obesity; Overweight; Regression Analysis; Risk Factors; Vitamin B 12 | 2007 |
The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.
Topics: Adult; Aged; Case-Control Studies; Cohort Studies; Europe; Female; Folic Acid; Gastritis, Atrophic; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; Stomach Neoplasms; Vitamin B 12 | 2007 |
Concurrent folate treatment prevents Na+,K+-ATPase activity inhibition and memory impairments caused by chronic hyperhomocysteinemia during rat development.
Topics: Aging; Animals; Chronic Disease; Cognition; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Maze Learning; Memory; Memory Disorders; Memory, Short-Term; Motor Activity; Nerve Tissue Proteins; Parietal Lobe; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Space Perception; Synaptic Membranes; Thiobarbituric Acid Reactive Substances; Vitamins | 2007 |
Growth-related changes of parameters of the methylation cycle and jejunal aminopeptidase M in the rat.
Topics: Aging; Animals; CD13 Antigens; Female; Folic Acid; Growth; Homocysteine; Jejunum; Methylation; Rats; Rats, Inbred Lew; Vitamin B 12 | 2008 |
In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Time Factors; Vitamin B 12 Deficiency | 2007 |
The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels.
Topics: Aged; Coronary Artery Disease; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Turkey; Vitamin B 12 | 2008 |
Homocysteine, migration and early vascular impairment in people of African descent.
Topics: Adult; Biomarkers; Black People; Cross-Sectional Studies; Emigration and Immigration; Female; Folic Acid; Homocysteine; Humans; Jamaica; Male; Middle Aged; Plethysmography; Risk Factors; Statistics, Nonparametric; United Kingdom; Vascular Diseases | 2008 |
Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis.
Topics: Age of Onset; Brain; Cognition Disorders; Disability Evaluation; Disease Progression; Folic Acid; Homocysteine; Hyperhomocysteinemia; Multiple Sclerosis; Multivariate Analysis; Neuropsychological Tests; Predictive Value of Tests; Up-Regulation; Vitamin B 12 Deficiency | 2008 |
Effect of folate, vitamin B6, and vitamin B12 intake and MTHFR C677T polymorphism on homocysteine concentrations of renal transplant recipients.
Topics: Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Function Tests; Kidney Transplantation; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Postoperative Complications; Vitamin B 12; Vitamin B 6 | 2007 |
Is homocysteine toxic in uremia?
Topics: Acetylcysteine; Antitoxins; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Myocardial Infarction; Recurrence; Reference Values; Renal Dialysis; Retrospective Studies; Risk Factors; Uremia | 2008 |
Plasma vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent study.
Topics: Adult; Aged; Analysis of Variance; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Odds Ratio; Prospective Studies; Risk Assessment; Risk Factors; Sweden; Vitamin B 12 | 2008 |
Homocysteine levels in epileptic children receiving antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Oxcarbazepine; Valproic Acid; Vitamin B 12 | 2007 |
Evidence for sex differences in the determinants of homocysteine concentrations.
Topics: Adult; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Regression Analysis; Sex Characteristics; Smoking; Vitamin B 12 | 2008 |
A comparison of some of the cardiovascular risk factors in vegetarian and omnivorous Turkish females.
Topics: Adult; Cardiovascular Diseases; Diet; Diet Records; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Middle Aged; Nutritional Status; Risk Factors; Turkey; Vitamin B 12 | 2008 |
The effects of raloxifene and tibolone on homocysteine and vascular histopathological changes.
Topics: Animals; Atherosclerosis; Carotid Arteries; Estrogen Replacement Therapy; Female; Folic Acid; Homocysteine; Norpregnenes; Raloxifene Hydrochloride; Rats; Rats, Wistar; Vitamin B 12 | 2007 |
The effect of antiepileptic drugs on vitamin B12 metabolism.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Case-Control Studies; Epilepsy; Erythrocytes, Abnormal; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neutrophils; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease.
Topics: Aged; Biomarkers; Body Mass Index; Coronary Artery Disease; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Obesity; Risk Factors; Vitamin B 12; Waist-Hip Ratio | 2008 |
Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Biomarkers; Central Nervous System; Comorbidity; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nerve Degeneration; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Up-Regulation; Vitamin B 12 | 2008 |
Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Body Weight; Diet; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Male; Methionine; Mice; S-Adenosylhomocysteine; Vitamin B 12; Vitamin B 6 | 2008 |
[Folic acid attenuates homocysteine induced human monocytes chemokine secretion via reducing NADPH oxidase activity].
Topics: Cells, Cultured; Chemokines; Folic Acid; Homocysteine; Humans; Interleukin-8; Monocytes; NADPH Oxidases; Oxidative Stress; Receptors, CCR2 | 2007 |
Homocysteinemia correlates with plasma thiol redox status in patients with end-stage renal disease.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cysteine; Dialysis; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Oxidation-Reduction; Statistics, Nonparametric; Sulfhydryl Compounds; Vitamin B Complex | 2008 |
Sport-related hyperhomocysteinaemia: a putative marker of muscular demand to be noted for cardiovascular risk.
Topics: Adult; Cardiovascular Diseases; Case-Control Studies; Cholesterol, HDL; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Interleukin-6; L-Lactate Dehydrogenase; Male; Muscle, Skeletal; Risk Factors; Sports; Vitamin B 12 | 2008 |
Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Benin; Biomarkers; DNA; DNA Probes; DNA, Viral; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; HLA-DR Antigens; HLA-DRB1 Chains; Homocysteine; Humans; Immunoassay; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Morbidity; Polymerase Chain Reaction; Polymorphism, Genetic; Vitamin B 12 | 2008 |
B-vitamins and prevention of dementia.
Topics: Aged; Aged, 80 and over; Cognition; Dementia; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2008 |
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressure Liquid; Electrochemistry; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Valproic Acid; Vitamin B 12 | 2008 |
In vitamin B12 deficiency, higher serum folate is associated with increased homocysteine and methylmalonic acid concentrations.
Topics: Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 2008 |
Total plasma homocysteine correlates in women with gestational diabetes.
Topics: Adult; Case-Control Studies; Diabetes, Gestational; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; Pregnancy; Vitamin B 12 | 2008 |
An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women.
Topics: Adolescent; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Longitudinal Studies; Male; Northern Ireland; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Tetrahydrofolate Dehydrogenase; Vitamin B Complex | 2008 |
Changes in folate, vitamin B12 and homocysteine associated with incident dementia.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Dementia; Dementia, Vascular; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Mental Status Schedule; Neuropsychological Tests; Predictive Value of Tests; Prospective Studies; Reference Values; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.
Topics: Adult; Case-Control Studies; Coronary Angiography; Coronary Vessels; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Odds Ratio; Polymorphism, Single Nucleotide | 2008 |
Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Apolipoprotein E4; China; Female; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors; Sex Factors | 2009 |
Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study.
Topics: Adult; Betaine; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methionine; Parturition; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, Third; Seychelles; Vitamin B 12; Vitamin B Complex | 2008 |
Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.
Topics: Adolescent; Adult; Alleles; Brazil; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Haplotypes; Homocysteine; Humans; Logistic Models; Maternal Age; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mothers; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk Factors; Statistics as Topic | 2008 |
Plasma homocysteine concentrations and the single nucleotide polymorphisms in the methionine synthase gene (MTR 2756A>G): Associations with the polycystic ovary syndrome An observational study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Female; Folic Acid; Homocysteine; Humans; Lipoproteins, LDL; Pilot Projects; Polycystic Ovary Syndrome; Polymorphism, Single Nucleotide; Prospective Studies | 2008 |
Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation.
Topics: Bone Density; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Middle Aged; Models, Biological; Postmenopause; Spine; Time Factors; Vitamin B 12 | 2008 |
Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diet Records; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Risk Factors; Transcobalamins; Vitamin B 12; Vitamin B 6; Vitamin B 6 Deficiency; Vitamin B Complex | 2008 |
C677T methylene-H4-folate-reductase variant decreases binocular accommodation.
Topics: Accommodation, Ocular; Adult; Female; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Vision, Binocular | 2008 |
Is folic acid good for everyone?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Cognition; Epigenesis, Genetic; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Neoplasms; Neural Tube Defects; Nutrition Policy; Nutritional Requirements; Public Health; Vitamin B 12 Deficiency | 2008 |
[Socio-demographic, lifestyle, gynecological, and obstetric predictors of serum or plasma concentrations of homocysteine, folic acid, and vitamins B12 and B6 among low-income women in São Paulo, Brazil].
Topics: Adult; Aged; Body Mass Index; Brazil; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Fluoroimmunoassay; Folic Acid; Homocysteine; Humans; Life Style; Middle Aged; Nutritional Status; Poverty; Reproductive History; Socioeconomic Factors; Vitamin B Complex; Women's Health Services; Young Adult | 2008 |
Protective effect against alcohol dependence of the thermolabile variant of MTHFR.
Topics: Alcohol Drinking; Alcoholic Neuropathy; Alcoholism; Control Groups; Female; Folic Acid; Folic Acid Deficiency; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk; Vitamin B 12 | 2008 |
The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis.
Topics: Adult; Austria; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Psoriasis; Vitamin B 12; White People | 2008 |
Psychosis, paraplegia and coma revealing methylenetetrahydrofolate reductase deficiency in a 56-year-old woman.
Topics: Brain; Brain Diseases, Metabolic, Inborn; Catatonia; Chromosome Aberrations; Chromosomes, Human, Pair 1; Coma; Dementia; Exons; Folic Acid; Genes, Recessive; Homocysteine; Humans; Magnetic Resonance Imaging; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Neurologic Examination; Paraplegia; Polymorphism, Genetic; Psychotic Disorders | 2008 |
Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.
Topics: Animals; Betaine; Diet; DNA Damage; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Genotype; Homocysteine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; RNA, Messenger; Thymine Nucleotides; Uridine Triphosphate | 2008 |
Homocysteine or renal impairment: which is the real cardiovascular risk factor?
Topics: Aged; Aged, 80 and over; Biomarkers; Brachial Artery; Cardiovascular Diseases; Carotid Arteries; Cross-Sectional Studies; Cystatin C; Cystatins; Female; Folic Acid; Follow-Up Studies; Glomerular Filtration Rate; Homocysteine; Humans; Kidney Diseases; Male; Middle Aged; Predictive Value of Tests; Regional Blood Flow; Regression Analysis; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
Trends in circulating concentrations of total homocysteine among US adolescents and adults: findings from the 1991-1994 and 1999-2004 National Health and Nutrition Examination Surveys.
Topics: Adolescent; Adult; Child; Cross-Sectional Studies; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Nutrition Surveys; United States | 2008 |
Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Discriminant Analysis; Female; Folic Acid; Homocysteine; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12 | 2008 |
Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression.
Topics: Aged; Cross-Sectional Studies; Depressive Disorder; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Male; Predictive Value of Tests; Vitamin B 12 Deficiency; Vitamin B Complex | 2008 |
Plasma homocysteine, vitamin B12 and folate levels in hydatidiform moles and histopathological subtypes.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hydatidiform Mole; Pregnancy; Statistics, Nonparametric; Uterine Neoplasms; Vitamin B 12 | 2008 |
Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; France; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Nutritional Status; Polymorphism, Genetic; Pregnancy; Prospective Studies; Risk Factors; Vitamin B Complex | 2008 |
Influence of the cystathionine beta-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations.
Topics: Adult; Cystathionine beta-Synthase; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Northern Ireland; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors | 2008 |
Homocysteine, vitamins, and vascular disease prevention: more negative results.
Topics: Evidence-Based Medicine; Folic Acid; Food, Fortified; Homocysteine; Humans; Meta-Analysis as Topic; Primary Prevention; Randomized Controlled Trials as Topic; Risk Factors; Vascular Diseases; Vitamins | 2008 |
Hopeful for a second HOPE-2 post hoc analysis.
Topics: Chronic Disease; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Randomized Controlled Trials as Topic; Vitamin B Complex | 2008 |
Genetic polymorphism of MTHFR G1793A in Chinese populations.
Topics: Asian People; Case-Control Studies; China; Ethnicity; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Population; Prevalence; Vitamin B 12 | 2008 |
[Serum folate and homocysteine concentrations in women smoking during pregnancy and in umbilical cord blood of newborns].
Topics: Adult; Birth Weight; Female; Fetal Blood; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Low Birth Weight; Infant, Newborn; Pregnancy; Smoking | 2007 |
[Smoking influence on the level of homocysteine and 5-methyltetrahydrofolic acid in active and non smokers].
Topics: Adult; Cotinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Smoking; Tetrahydrofolates | 2007 |
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.
Topics: Animals; Brain; Disease Models, Animal; Female; Folic Acid; Genotype; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Survival Rate; Tetrahydrofolates | 2008 |
Homocysteine, folate and cognition in a large community-based sample of elderly people--the 3C Dijon Study.
Topics: Aged; Aged, 80 and over; Cognition; Cognition Disorders; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; France; Homocysteine; Humans; Hyperhomocysteinemia; Male; Neuropsychological Tests; Prospective Studies; Residence Characteristics; Risk Factors; Urban Health | 2008 |
Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum; Folic Acid; Homocysteine; Humans; Models, Biological; Protein Binding; Reactive Oxygen Species; Ultraviolet Rays | 2008 |
[Serum levels of homocysteine and folate in neonates with asphyxia].
Topics: Asphyxia Neonatorum; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Infant, Premature; Male; Sex Characteristics | 2008 |
Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Amniotic Fluid; Case-Control Studies; Child; Congenital Abnormalities; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Transcobalamins; Vitamin B 12 | 2008 |
Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Inflammation; Mice; Mice, Transgenic; Motor Neurons; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rotarod Performance Test; Spinal Cord; Superoxide Dismutase; Vitamin B 12; Vitamin B Complex | 2008 |
Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Sensitivity and Specificity | 2008 |
Abnormal folate metabolism as a risk factor for first-trimester spontaneous abortion.
Topics: Abortion, Spontaneous; Adolescent; Adult; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Homocysteine; Humans; Pilot Projects; Pregnancy; Pregnancy Trimester, First; Risk Factors | 2008 |
Homocysteine and folate status in an era of folic acid fortification: balancing benefits, risks, and B-vitamins.
Topics: Cleft Lip; Cleft Palate; Folic Acid; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutrition Surveys; Risk Assessment; Vitamin B Complex | 2008 |
Reduced urinary excretion of homocysteine could be the reason of elevated plasma homocysteine in patients with psychiatric illnesses.
Topics: Acute Disease; Adult; Biomarkers; Chronic Disease; Female; Folic Acid; Homocysteine; Humans; Male; Meta-Analysis as Topic; Middle Aged; Psychotic Disorders; Vitamin B 12 | 2008 |
Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behçet's disease.
Topics: Adolescent; Adult; Behcet Syndrome; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Middle Aged; Promoter Regions, Genetic; Tandem Repeat Sequences; Thymidylate Synthase; Venous Thrombosis; Young Adult | 2008 |
Homocysteine-lowering B vitamin therapy in cardiovascular prevention--wrong again?
Topics: Cardiovascular Diseases; Dietary Supplements; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
CSF/serum folate gradient: physiology and determinants with special reference to dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood-Brain Barrier; Case-Control Studies; Choroid Plexus; Dementia, Vascular; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Risk Factors; Serum Albumin; Vitamin B 12 | 2008 |
Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls.
Topics: Biomarkers; Female; Fluorides; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Incidence; India; Infant, Newborn; Male; Neural Tube Defects; Parents; Prognosis; Retrospective Studies; Risk Factors; Vitamin B 12 | 2008 |
Traffic-related particles are associated with elevated homocysteine: the VA normative aging study.
Topics: Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Biomarkers; Carbon; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Particulate Matter; Sulfur; Vehicle Emissions; Vitamin B 12 | 2008 |
Reduction of the genomic damage level in haemodialysis patients by folic acid and vitamin B12 supplementation.
Topics: Aged; Aged, 80 and over; Case-Control Studies; DNA Damage; Female; Folic Acid; Genome, Human; Homocysteine; Humans; Kidney Failure, Chronic; Lymphocytes; Male; Micronucleus Tests; Middle Aged; Neoplasms; Prospective Studies; Renal Dialysis; Vitamin B 12 | 2008 |
Hyperglycemia-induced membrane lipid peroxidation and elevated homocysteine levels are poorly attenuated by exogenous folate in embryonic chick brains.
Topics: Animals; Blood Glucose; Brain; Chick Embryo; Fatty Acids; Folic Acid; Glucose; Homocysteine; Lipid Peroxidation; Lipid Peroxides; Membrane Lipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom.
Topics: Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Male; Risk Factors; United Kingdom; Vitamin B 12 | 2008 |
The homocysteine paradox.
Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Folic Acid; Gene Expression; Homocysteine; Humans; Methionine; Mice; Mice, Transgenic; Recombinant Proteins | 2008 |
The administration of folic acid reduces intravascular oxidative stress in diabetic rabbits.
Topics: Alloxan; Animals; Aorta; Body Weight; Diabetes Mellitus, Experimental; Dinoprost; Epoprostenol; Folic Acid; Homocysteine; Male; NADPH Oxidases; Oxidative Stress; Rabbits; Superoxides | 2008 |
Pilot study of homocysteine and cysteine in patients with thrombosis in different vascular sites. Epidemiology and response to folate.
Topics: Adult; Aged; Cysteine; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Pilot Projects; Thrombosis; Vitamin B 12 | 2009 |
Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link.
Topics: Autistic Disorder; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Selection, Genetic | 2008 |
Changes in predictors and status of homocysteine in young male adults after a dietary intervention with vegetables, fruits and bread.
Topics: Adolescent; Adult; Bread; Folic Acid; Fruit; Homocysteine; Humans; Hyperhomocysteinemia; Male; Norway; Riboflavin; Surveys and Questionnaires; Treatment Outcome; Vegetables; Vitamin B 12; Vitamin B Complex | 2008 |
[Does an association between increased homocystein levels and cognitive dysfunction also exist in multimorbid geriatric patients].
Topics: Aged; Aged, 80 and over; Cognition Disorders; Female; Folic Acid; Geriatric Assessment; Germany; Homocysteine; Humans; Incidence; Male; Reproducibility of Results; Risk Assessment; Risk Factors; Sensitivity and Specificity; Statistics as Topic | 2009 |
Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China.
Topics: Adult; Case-Control Studies; China; Diet; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Luminescent Measurements; Maternal Nutritional Physiological Phenomena; Neural Tube Defects; Pregnancy; Pregnant Women; Risk Factors; Ultrasonography; Vitamin B 12; Young Adult | 2009 |
Commutability of NIST SRM 1955 Homocysteine and Folate in Frozen Human Serum with selected total homocysteine immunoassays and enzymatic assays.
Topics: Blood Chemical Analysis; Chromatography, Liquid; Enzymes; Folic Acid; Freezing; Homocysteine; Humans; Immunoassay; Linear Models; Models, Statistical; Predictive Value of Tests; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tetrahydrofolates; United States | 2008 |
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents | 2008 |
Homocysteine and related B-vitamin status in coeliac disease: Effects of gluten exclusion and histological recovery.
Topics: Celiac Disease; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Riboflavin; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Gas chromatographic-mass spectrometric analysis of biomarkers related to folate and cobalamin status in human serum after dimercaptopropanesulfonate reduction and heptafluorobutyl chloroformate derivatization.
Topics: Alkanesulfonic Acids; Biomarkers; Fluorocarbons; Folic Acid; Formates; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Methylmalonic Acid; Oxidation-Reduction; Sulfhydryl Compounds; Vitamin B 12 | 2008 |
Serum homocysteine levels and cognitive functioning in euthymic bipolar patients.
Topics: Adult; Age Factors; Bipolar Disorder; Cognition Disorders; Demography; Diagnostic and Statistical Manual of Mental Disorders; Dysthymic Disorder; Female; Folic Acid; Homocysteine; Humans; Male; Neuropsychological Tests; Severity of Illness Index; Sex Factors; Vitamin B 12 | 2009 |
Plasma total homocysteine: instigator or indicator of cardiovascular disease?
Topics: Biomarkers; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Inflammation; Risk Factors | 2008 |
Association between C677T/MTHFR genotype and homocysteine concentration in a Kazakh population.
Topics: Adult; Carbon-Nitrogen Ligases; Creatinine; Ethnicity; Female; Folic Acid; Genotype; Homocysteine; Humans; Japan; Male; Population; Serum Albumin; Vitamin B 12; Vitamin B Complex | 2008 |
High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.
Topics: Alleles; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Carbon; Case-Control Studies; Chi-Square Distribution; Chromatography; Female; Folic Acid; Homocysteine; Humans; Maternal Age; Models, Biological; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine | 2008 |
Coffee consumption and circulating B-vitamins in healthy middle-aged men and women.
Topics: Alcohol Drinking; Body Mass Index; Coffee; Female; Folic Acid; Health; Homocysteine; Humans; Life Style; Male; Middle Aged; Smoking; Vitamin B Complex | 2008 |
Methionine, folic acid and vitamin B12 in growing-finishing pigs: impact on growth performance and meat quality.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Body Composition; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Male; Meat; Methionine; Nutritional Requirements; Random Allocation; Swine; Vitamin B 12; Vitamin B Complex; Weight Gain | 2008 |
Folate and cobalamin status in relation to breastfeeding and weaning in healthy infants.
Topics: Age Distribution; Analysis of Variance; Breast Feeding; Child, Preschool; Diet Records; Female; Folic Acid; Homocysteine; Humans; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Longitudinal Studies; Male; Methylmalonic Acid; Norway; Nutritional Status; Reference Values; Surveys and Questionnaires; Vitamin B 12; Vitamin B Complex; Weaning | 2008 |
Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank.
Topics: Carbon-Nitrogen Ligases; Cystathionine beta-Synthase; Ethnicity; Ferredoxin-NADP Reductase; Folic Acid; Food, Fortified; Genetic Variation; Genotype; Homocysteine; Humans; Nutrigenomics; Nutrition Surveys; Polymorphism, Genetic; Prevalence; United States | 2008 |
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cell Line, Tumor; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Pregnancy; Teratogens; Up-Regulation; Valproic Acid | 2008 |
Folate and clefts of the lip and palate--a U.K.-based case-control study: Part II: Biochemical and genetic analysis.
Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Fathers; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Single Nucleotide; Pregnancy; Regression Analysis; Surveys and Questionnaires; United Kingdom | 2008 |
Homocysteine, folate and vitamin B(12) in puerperal cerebral venous thrombosis.
Topics: Adolescent; Adult; Confidence Intervals; Female; Folic Acid; Homocysteine; Humans; Intracranial Thrombosis; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Odds Ratio; Prothrombin; Puerperal Disorders; Risk; Risk Assessment; Statistics as Topic; Venous Thrombosis; Vitamin B 12 | 2008 |
Increased folate intake with no changes in serum homocysteine and decreased levels of C-reactive protein in patients with inflammatory bowel diseases.
Topics: Adult; Anthropometry; C-Reactive Protein; Diet; Female; Folic Acid; Homocysteine; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Nutritional Status; Vitamin B 12; Young Adult | 2009 |
Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Case-Control Studies; Cognition Disorders; Disulfides; Female; Folic Acid; Homocysteine; Humans; Male; Malondialdehyde; Middle Aged; Neopterin; Nerve Degeneration; Oxidative Stress; Protein Carbonylation; Serum Albumin; Severity of Illness Index; Vitamin B 12 | 2008 |
Homocysteine levels and sustained virological response to pegylated-interferon alpha2b plus ribavirin therapy for chronic hepatitis C: a prospective study.
Topics: Antiviral Agents; Folic Acid; Hepacivirus; Hepatitis C, Chronic; Homocysteine; Humans; Interferon alpha-2; Interferon-alpha; Italy; Methylenetetrahydrofolate Dehydrogenase (NADP); Polyethylene Glycols; Polymorphism, Genetic; Prospective Studies; Recombinant Proteins; Ribavirin; RNA, Viral; ROC Curve; Vitamin B 12 | 2009 |
Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation.
Topics: Adult; Biomarkers; Chorionic Gonadotropin; Estradiol; Female; Fertilization in Vitro; Folic Acid; Follicular Fluid; Homocysteine; Humans; Ovarian Follicle; Ovulation Induction; Pyridoxal Phosphate; Surveys and Questionnaires; Vitamin B 12 | 2008 |
Ethnicity and folate influence choline status in young women consuming controlled nutrient intakes.
Topics: Adolescent; Adult; Betaine; Black or African American; Body Mass Index; Choline; Diet; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mexican Americans; Middle Aged; Phosphatidylcholines; Sphingomyelins; White People | 2008 |
Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men.
Topics: Adult; Coronary Disease; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Linear Models; Logistic Models; Male; Metabolic Syndrome; Middle Aged; Sex Factors; Turkey; Vitamin B 12 | 2008 |
Gene-environment interactions reveal a homeostatic role for cholesterol metabolism during dietary folate perturbation in mice.
Topics: Animals; Cholesterol; Choline Kinase; Diet; DNA Methylation; Female; Folic Acid; Gene Expression Regulation; Homocysteine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains | 2008 |
Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression.
Topics: Adult Stem Cells; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cells, Cultured; Cognition Disorders; Cyclin E; Dementia; Dentate Gyrus; Disease Models, Animal; Fibroblast Growth Factor 2; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Hyperhomocysteinemia; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurodegenerative Diseases; Neurons; Trigeminal Caudal Nucleus | 2008 |
Dietary folate intake during pregnancy and birth weight in Japan.
Topics: Adult; Biomarkers; Birth Weight; Energy Intake; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant, Newborn; Japan; Longitudinal Studies; Male; Maternal Nutritional Physiological Phenomena; Nutritional Requirements; Nutritional Status; Pregnancy; Pregnancy Outcome; Prospective Studies; Vitamin B Complex | 2008 |
Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Analysis of Variance; Body Mass Index; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nutrition Assessment; Nutritional Status; Polymorphism, Genetic; Sex Factors; Smoking; Spain; Vitamin B 12; Vitamin B Complex | 2008 |
Vitamin B12 and homocysteine status in asymptomatic Indian toddlers.
Topics: Body Height; Body Weight; Child, Preschool; Comorbidity; Cross-Sectional Studies; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Prevalence; Surveys and Questionnaires; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
Validation of a composite scoring scheme in the diagnosis of folate deficiency in a pediatric and adolescent dialysis cohort.
Topics: Adolescent; Analysis of Variance; Cohort Studies; Diagnosis, Differential; Erythrocytes; Erythropoietin; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Iron; Kidney Failure, Chronic; Male; Predictive Value of Tests; Recombinant Proteins; Renal Dialysis; Sensitivity and Specificity | 2008 |
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.
Topics: Animals; Disease Susceptibility; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylation; Mice; Mice, Transgenic; Mutation; Neural Tube Defects; Paired Box Transcription Factors; PAX3 Transcription Factor | 2008 |
Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study.
Topics: Age Factors; Aged; Black People; Cerebrovascular Disorders; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Leukoaraiosis; London; Male; Middle Aged; Risk Factors; Sex Factors; Stroke; Vitamin B Complex | 2008 |
Folate, homocysteine, and candidate genes for vascular disease in children with type 1 diabetes.
Topics: Child; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vascular Diseases | 2008 |
Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Asian; Black or African American; Coronary Artery Disease; Cystathionine beta-Synthase; Enzymes; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Hispanic or Latino; Homocysteine; Humans; Lupus Erythematosus, Systemic; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Predictive Value of Tests; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; White People | 2008 |
Plasma homocysteine thiolactone associated with risk of macrovasculopathy in Chinese patients with type 2 diabetes mellitus.
Topics: Age Factors; Asian People; Body Mass Index; China; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Middle Aged; Risk Factors; Smoking; Time Factors; Vitamin B 12 | 2008 |
Polymorphisms in the CBS gene and homocysteine, folate and vitamin B12 levels: association with polymorphisms in the MTHFR and MTRR genes in Brazilian children.
Topics: Brazil; Child; Child, Preschool; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Dehydrogenase (NAD+); Multivariate Analysis; Polymorphism, Genetic; Vitamin B 12 | 2008 |
Dietary folate intake, blood folate status, and urinary folate catabolite excretion in Korean women of childbearing age.
Topics: Adolescent; Adult; Age Factors; Anthropometry; Dietary Proteins; Eating; Energy Metabolism; Erythrocytes; Feeding Behavior; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Korea; Middle Aged; Nutritional Status; Vitamin B Complex; Young Adult | 2008 |
Folate deprivation, the methionine cycle, and Alzheimer's disease.
Topics: Alzheimer Disease; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2008 |
Effect of folic acid and B vitamins on cardiovascular disease in women.
Topics: Adult; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Vitamin B Complex | 2008 |
[Thromboembolic events, abortions and a sick infant--unusual presentation of a vitamin deficiency].
Topics: Abortion, Habitual; Adult; Anemia, Pernicious; Autoimmune Diseases; Breast Feeding; Diagnosis, Differential; Failure to Thrive; Female; Folic Acid; Gastritis, Atrophic; Homocysteine; Humans; Infant; Intrinsic Factor; Methylmalonic Acid; Parietal Cells, Gastric; Pregnancy; Thromboembolism; Vitamin B 12 Deficiency | 2008 |
Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates.
Topics: Adult; Brazil; DNA; Embryonic Development; Ethnicity; Female; Folic Acid; Glutamate Carboxypeptidase II; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylhomocysteine; S-Adenosylmethionine; Socioeconomic Factors; Vitamin B 12; Vitamin B Complex; Young Adult | 2008 |
Serum homocysteine: relationship with circulating levels of cortisol and ascorbate.
Topics: Aging; Ascorbic Acid; Cardiovascular Diseases; Female; Folic Acid; Health Status; Homocysteine; Humans; Hydrocortisone; Linear Models; Male; Middle Aged; Nutritional Status; Risk Factors | 2008 |
Raised homocysteine and low folate and vitamin B-12 concentrations predict cognitive decline in community-dwelling older Japanese adults.
Topics: Age Factors; Aged; Aged, 80 and over; Albumins; Cholesterol; Cognition Disorders; Creatinine; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Japan; Male; Middle Aged; Regression Analysis; Vitamin B 12 | 2008 |
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Topics: Aged; Chromosome Aberrations; Cohort Studies; DNA Damage; DNA Methylation; Female; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Uracil | 2008 |
Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Middle Aged; Mutation; Myocardial Infarction; Tunisia; Vitamin B 12 | 2008 |
Association of recreational physical activity with homocysteine, folate and lipid markers in young women.
Topics: Adolescent; Adult; Biomarkers; Cardiovascular Diseases; Exercise; Female; Folic Acid; Homocysteine; Humans; Lipids; Motor Activity; Recreation; Risk Factors | 2009 |
Nitrous oxide and postoperative cardiovascular morbidity.
Topics: Anesthetics, Inhalation; Cardiovascular Diseases; Confounding Factors, Epidemiologic; Folic Acid; Homocysteine; Humans; Nitrous Oxide; Postoperative Complications | 2008 |
Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Biomarkers; Brain Chemistry; Carcinogens; Carrier Proteins; Colitis; Colonic Neoplasms; Dextran Sulfate; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Deficiency; Food, Formulated; Heterozygote; Homocysteine; Intestinal Mucosa; Membrane Transport Proteins; Mice; Mice, Knockout; Models, Animal; Nutritional Status; Precancerous Conditions; Receptors, Cell Surface; Reduced Folate Carrier Protein | 2009 |
Cognitive performance and plasma levels of homocysteine, vitamin B12, folate and lipids in patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Cholesterol, HDL; Cholesterol, LDL; Cognition; Cross-Sectional Studies; Databases, Factual; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Psychomotor Performance; Sex Characteristics; Triglycerides; Vitamin B 12 | 2008 |
Homocysteine is not associated with global motor or cognitive measures in nondemented older Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Cognition; Creatinine; Female; Folic Acid; Genotype; Homocysteine; Humans; Inactivation, Metabolic; Levodopa; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Motor Skills; Neuropsychological Tests; Parkinson Disease; Severity of Illness Index; Vitamin B Complex | 2009 |
Invited commentary: Preventing neural tube defects and more via food fortification?
Topics: Confidence Intervals; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Maryland; Mothers; Neural Tube Defects; Pregnancy; Prenatal Care; United States; Vitamin B Complex | 2009 |
Higher folate intake is related to lower risk of Alzheimer's disease in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Female; Folic Acid; Homocysteine; Humans; Male; Nutrition Assessment; Prospective Studies; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
The relation between serum homocysteine level and eye involvement in Behçet's disease.
Topics: Adolescent; Adult; Behcet Syndrome; Comorbidity; Eye Diseases; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Young Adult | 2008 |
Plasma vitamin B12 status and cerebral white-matter lesions.
Topics: Aged; Biomarkers; Brain; Cerebral Infarction; Cerebrovascular Circulation; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Myelin Sheath; Neuropsychological Tests; Population Surveillance; Prevalence; Risk Factors; Severity of Illness Index; Vitamin B 12 | 2009 |
Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood of rats: protective effect of folic acid.
Topics: Animals; Antioxidants; Catalase; DNA; DNA Damage; Folic Acid; Glutathione Peroxidase; Homocysteine; Hyperhomocysteinemia; Micronucleus Tests; Parietal Lobe; Rats; Rats, Wistar | 2009 |
Is ischemic stroke risk related to folate status or other nutrients correlated with folate intake?
Topics: Adult; Aged; Aged, 80 and over; Blood Proteins; Brain Ischemia; Diet; Feeding Behavior; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Life Style; Male; Micronutrients; Middle Aged; Nutritional Requirements; Risk Factors; Sampling Studies; Surveys and Questionnaires; Taiwan | 2008 |
Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Flour; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Iran; Middle Aged; Neural Tube Defects; Nutritional Status; Outcome and Process Assessment, Health Care; Triticum; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2008 |
Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study.
Topics: Aged, 80 and over; Anemia; Cross-Sectional Studies; Erythrocyte Indices; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Hemoglobins; Homocysteine; Humans; Male; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 2008 |
A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate.
Topics: Adult; Aged; Aged, 80 and over; Base Sequence; Cohort Studies; Cross-Sectional Studies; Dietary Supplements; DNA Primers; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Polymorphism, Genetic; Sequence Deletion; Tetrahydrofolate Dehydrogenase | 2008 |
Prevalence of MTHFR C677T polymorphism in north Indian mothers having babies with Trisomy 21 Down syndrome.
Topics: Adult; Diet; DNA; Down Syndrome; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; India; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Vitamins; Young Adult | 2008 |
Folate status of young Canadian women after folic acid fortification of grain products.
Topics: Adolescent; Biomarkers; Cross-Sectional Studies; Dietary Supplements; Edible Grain; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutritional Requirements; Nutritional Status; United States; Young Adult | 2008 |
Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats.
Topics: Animals; Disease Models, Animal; Extracellular Matrix; Folic Acid; Homocysteine; Hyperhomocysteinemia; Kidney Failure, Chronic; Kidney Glomerulus; Matrix Metalloproteinases; NADPH Oxidases; Oxidative Stress; Proto-Oncogene Proteins c-vav; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; RNA; Sclerosis; Superoxides; Tissue Inhibitor of Metalloproteinase-1; Transfection | 2009 |
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.
Topics: Animals; Animals, Genetically Modified; Biomarkers; DNA; Folic Acid; Formate-Tetrahydrofolate Ligase; Formates; Glycine Hydroxymethyltransferase; Homocysteine; Methylation; Mice; Thymidine Monophosphate; Uracil | 2009 |
Evaluation of traditional and emerging cardiovascular risk factors in patients with non-arteritic anterior ischemic optic neuropathy: a case-control study.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Case-Control Studies; Dyslipidemias; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Hypertension; Lipoprotein(a); Male; Middle Aged; Optic Neuropathy, Ischemic; Risk Factors; Thrombophilia; Vitamin B 12; Vitamin B 6 | 2009 |
Serum total homocysteine, folate, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype and subclinical atherosclerosis.
Topics: Aged; Atherosclerosis; Base Sequence; Cross-Sectional Studies; DNA Primers; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged | 2009 |
Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis?
Topics: Aged; Aged, 80 and over; Atherosclerosis; Biomarkers; Body Mass Index; Creatinine; Diabetes Mellitus; Diabetic Angiopathies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Models, Biological; Overweight; Regression Analysis; Vitamin B 12 | 2009 |
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult | 2009 |
Plasma homocysteine, folate, and vitamin B12 levels in patients with laryngeal cancer.
Topics: Adult; Aged; Aged, 80 and over; Female; Folic Acid; Homocysteine; Humans; Laryngeal Neoplasms; Male; Middle Aged; Vitamin B 12 | 2008 |
Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation.
Topics: Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Folic Acid; Glucose; Homocysteine; Humans; Insulin; Methionine; Methylation; S-Adenosylmethionine; Sulfur | 2009 |
Homocyst(e)ine, folate, and vitamin B12 status in a cohort of Welsh young people aged 12-13 years old.
Topics: Adolescent; Age Factors; Body Mass Index; Child; Cohort Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Reference Values; Sex Factors; Vitamin B 12; Waist Circumference; Wales | 2008 |
Do dietary patterns in older men influence change in homocysteine through folate fortification? The Normative Aging Study.
Topics: Aged; Aging; Alcohol Drinking; Boston; Cluster Analysis; Diet; Dietary Supplements; Folic Acid; Food, Fortified; Fruit; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Vegetables; Vitamin B Complex | 2009 |
Demographic, lifestyle, and health characteristics and serum B vitamin status are determinants of plasma total homocysteine concentration in the post-folic acid fortification period, 1999-2004.
Topics: Adult; Demography; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Nutrition Surveys; Vitamin B Complex | 2009 |
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
Topics: Blotting, Western; Breast Neoplasms; Colonic Neoplasms; CpG Islands; DNA Damage; DNA Methylation; Folic Acid; Gene Expression Regulation, Neoplastic; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Risk Factors; Tumor Cells, Cultured; Uracil | 2009 |
Tissue methionine cycle activity and homocysteine metabolism in female rats: impact of dietary methionine and folate plus choline.
Topics: Animals; Body Composition; Choline; Diet; Dietary Proteins; Female; Folic Acid; Homocysteine; Methionine; Models, Biological; Rats; Tissue Distribution | 2009 |
Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Anemia, Pernicious; Cognition Disorders; Drug Interactions; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Middle Aged; Nutrition Surveys; Nutritional Status; Odds Ratio; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency | 2009 |
[Vitamin B substitution. No protection for the heart -- but for the brain!].
Topics: Cohort Studies; Controlled Clinical Trials as Topic; Folic Acid; Homocysteine; Humans; Meta-Analysis as Topic; Myocardial Infarction; Prospective Studies; Retrospective Studies; Risk Factors; Stroke; Time Factors; Vitamin B 12; Vitamin B 6 | 2008 |
The relationship of homocyteine, B12 and folic acid with the bone mineral density of the femur and lumbar spine in Turkish postmenopausal women.
Topics: Absorptiometry, Photon; Adult; Aged; Bone Density; Cross-Sectional Studies; Female; Femur; Folic Acid; Homocysteine; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis; Postmenopause; Turkey; Vitamin B 12 | 2009 |
Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis.
Topics: Adult; Disability Evaluation; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Female; Folic Acid; Hematocrit; Hemoglobins; Homocysteine; Humans; Immunoglobulin G; Male; Middle Aged; Multiple Sclerosis; Oligoclonal Bands; Retrospective Studies; Vitamin B 12; Young Adult | 2009 |
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.
Topics: Adolescent; Adult; Biomarkers; Choline; Dose-Response Relationship, Drug; Female; Folic Acid; Folic Acid Deficiency; Genetic Variation; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Mexican Americans; Nutritional Status; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Premenopause; Young Adult | 2009 |
Folate, related B vitamins, and homocysteine in childhood and adolescence: potential implications for disease risk in later life.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Male; Reference Values; Risk Factors; Vitamin B Complex | 2009 |
The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study.
Topics: Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Membrane Transport Proteins; Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors | 2008 |
Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Colorectal Neoplasms; Diet; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pregnancy; Prenatal Nutritional Physiological Phenomena; Random Allocation; Thymine Nucleotides; Uridine Triphosphate; Weaning | 2009 |
Evaluation of plasma folate and homocysteine concentrations in cats with and without oral squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; Female; Folic Acid; Homocysteine; Male; Mouth Neoplasms | 2008 |
Maternal serum homocysteine and risk for neural tube defects in a Texas-Mexico border population.
Topics: Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Mexico; Neural Tube Defects; Pregnancy; Pregnancy Complications; Retrospective Studies; Risk Factors; Texas; Vitamin B 12 | 2009 |
Validation of the folate food frequency questionnaire in vegetarians.
Topics: Adult; Biomarkers; Body Mass Index; Croatia; Diet Surveys; Diet, Vegetarian; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Nutritional Status; Principal Component Analysis; Surveys and Questionnaires | 2009 |
Validation of the folate food frequency questionnaire with serum and erythrocyte folate and plasma homocysteine.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Body Mass Index; Croatia; Diet; Diet Surveys; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Middle Aged; Nutritional Status; Principal Component Analysis; Surveys and Questionnaires; Young Adult | 2009 |
Relationship of homocysteine with other risk factors and outcome of ischemic stroke.
Topics: Adult; Aged; Brain Ischemia; Comorbidity; Diabetes Mellitus; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypertension; India; Male; Middle Aged; Obesity; Risk Factors; Severity of Illness Index; Smoking; Stroke; Tomography, X-Ray Computed; Vitamin B 12 | 2009 |
[Hiperhomocysteinemia in active and passive smokers and the levels of folate and vitamin B6 in plasma].
Topics: Adult; Biomarkers; Environmental Monitoring; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Middle Aged; Plasma; Reference Values; Smoking; Tobacco Smoke Pollution; Vitamin B 6; Young Adult | 2008 |
Effects of metoprolol and diltiazem on plasma homocysteine levels in patients with isolated coronary artery ectasia.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Artery Disease; Dilatation, Pathologic; Diltiazem; Female; Folic Acid; Homocysteine; Humans; Male; Metoprolol; Middle Aged; Treatment Outcome; Vitamin B 12 | 2009 |
HuSKY: a healthy nutrition score based on food intake of children and adolescents in Germany.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Eating; Emigration and Immigration; Folic Acid; Germany, East; Germany, West; Health Status Indicators; Homocysteine; Humans; Linear Models; Male; Nutrition Surveys; Nutritional Status; Russia; Sex Factors; Socioeconomic Factors; Surveys and Questionnaires; Turkey | 2009 |
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.
Topics: Animals; Cystathionine beta-Synthase; Diet; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Membrane Transport Proteins; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Knockout | 2009 |
Homocysteine, vitamin B12 and folic acid levels in psoriasis patients.
Topics: Adult; Case-Control Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psoriasis; Vitamin B 12 | 2009 |
Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype.
Topics: Adolescent; Adult; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexican Americans; Middle Aged; Mutation; Phosphatidylethanolamine N-Methyltransferase; Riboflavin | 2009 |
Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease.
Topics: Aged; Aryldialkylphosphatase; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Vitamin B 12 | 2009 |
IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid.
Topics: Biomarkers; Female; Fertilization in Vitro; Folic Acid; Follicular Fluid; Homocysteine; Humans; Pregnancy; Pregnancy Rate; Sperm Injections, Intracytoplasmic; Vitamin B 12 | 2009 |
Association between Helicobacter pylori-infection, C-reactive protein and status of B vitamins.
Topics: C-Reactive Protein; Cross-Sectional Studies; Female; Folic Acid; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
Homocysteine-lowering B vitamins do not lower mortality or cardiovascular events.
Topics: Aged; Aortic Valve Stenosis; Cardiovascular Diseases; Coronary Angiography; Coronary Artery Disease; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk; Survival Analysis; Survival Rate; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2008 |
Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
Topics: Adolescent; Adult; Celiac Disease; Creatinine; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pantothenic Acid; Polymorphism, Single Nucleotide; Vitamin B 12; Vitamin B Complex; Young Adult | 2009 |
Supplemented creatine induces changes in human metabolism of thiocompounds and one- and two-carbon units.
Topics: Adult; Biomarkers; Biotransformation; Creatine; Creatinine; Dietary Proteins; Dietary Supplements; Folic Acid; Homocysteine; Humans; Male; Oxidation-Reduction; Thioglycolates; Time Factors; Vitamin B 12; Young Adult | 2010 |
[Relationship between smoking and homocysteine concentration in ischemic stroke patients].
Topics: Aged; Brain Ischemia; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Risk Factors; Sex Factors; Smoking; Stroke; Vitamin B 12 | 2008 |
Folic acid supplementation provided in utero and during lactation reduces the number of terminal end buds of the developing mammary glands in the offspring.
Topics: Animal Feed; Animals; Dietary Supplements; Female; Folic Acid; Homocysteine; Lactation; Male; Mammary Glands, Animal; Maternal Exposure; Pregnancy; Rats; Rats, Sprague-Dawley; Time Factors; Vitamins | 2009 |
Commentary to: "Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid".
Topics: Age Factors; Anticonvulsants; Carotid Stenosis; Child; Endothelial Cells; Epilepsy; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intracranial Arteriosclerosis; Lipid Metabolism Disorders; Risk Factors; Tunica Intima; Valproic Acid | 2009 |
Urinary methylmalonic acid levels in patients with acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Stroke; Vitamin B 12 | 2009 |
Deprivation of folate and B12 increases neurodegeneration beyond that accompanying deprivation of either vitamin alone.
Topics: Calcium; Cell Line, Tumor; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Nerve Degeneration; Neuroblastoma; Neurons; Reactive Oxygen Species; Vitamin B 12; Vitamin B 12 Deficiency | 2009 |
High-dose B vitamin supplements and Alzheimer disease.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cognition Disorders; Dietary Supplements; Folic Acid; Homocysteine; Humans; Vitamin B Complex | 2009 |
Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease.
Topics: Aged; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Female; Folic Acid; Forced Expiratory Volume; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Logistic Models; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Risk Factors; Thrombosis; Vital Capacity; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency | 2009 |
High milk consumers have an increased risk of folate receptor blocking autoantibody production but this does not affect folate status in Spanish men and women.
Topics: Adolescent; Adult; Aged; Animals; Autoantibodies; Carrier Proteins; Cross-Sectional Studies; Diet; Diet Records; Erythrocytes; Female; Folate Receptors, GPI-Anchored; Folic Acid; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Milk; Polymorphism, Genetic; Receptors, Cell Surface; Spain; Vitamin B 12 | 2009 |
Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Case-Control Studies; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Middle Aged; Polymorphism, Genetic; Risk Factors | 2010 |
Serum homocysteine level in patients with ankylosing spondylitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Methotrexate; Middle Aged; Severity of Illness Index; Spondylitis, Ankylosing; Sulfasalazine | 2009 |
Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in Parkinson's disease.
Topics: Analysis of Variance; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Matched-Pair Analysis; Middle Aged; Nerve Degeneration; Parkinson Disease; Reference Values; Statistics, Nonparametric; Vitamin B 12 | 2009 |
Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function.
Topics: Adult; Aged; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Health Surveys; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Prospective Studies; Riboflavin; Risk; Sex Distribution; Sweden; Vitamin B 12; Vitamin B 6 | 2009 |
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Female; Folic Acid; Fucosyltransferases; Galactoside 2-alpha-L-fucosyltransferase; Genome-Wide Association Study; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Transcobalamins; Vitamin B 12; Vitamin B 6 | 2009 |
Variations in folate pathway genes are associated with unexplained female infertility.
Topics: Adult; Carrier Proteins; Cross-Sectional Studies; Cystathionine gamma-Lyase; Female; Folate Receptor 1; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Association Studies; Genetic Variation; Homocysteine; Humans; Infertility, Female; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Receptors, Cell Surface; Reduced Folate Carrier Protein; Signal Transduction; Transcobalamins; Vitamin B 12 | 2010 |
Association between cholesterols, homocysteine and silent brain infarcts.
Topics: Adult; Aged; Aged, 80 and over; Blood Chemical Analysis; Brain Infarction; Cardiovascular Diseases; Cholesterol; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Lipoproteins, LDL; Magnetic Resonance Imaging; Male; Middle Aged; Risk Factors; Sex Factors; Vitamin B 12; Young Adult | 2009 |
[Plasma homocysteine concentration in patients with ischaemic stroke caused by large or small vessel disease].
Topics: Brain Ischemia; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2009 |
Plasma homocysteine and cerebrospinal fluid neurodegeneration biomarkers in mild cognitive impairment and dementia.
Topics: Aged; Amyloid beta-Peptides; Biomarkers; Chromatography, High Pressure Liquid; Creatinine; Dementia; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Germany; Homocysteine; Humans; Immunoassay; Linear Models; Male; Middle Aged; Nephelometry and Turbidimetry; Nerve Degeneration; Peptide Fragments; tau Proteins; Vitamin B 12 | 2009 |
Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data.
Topics: Adult; Chromatography, Liquid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Mass Spectrometry; Middle Aged; Phenotype; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Young Adult | 2009 |
Association of maternal serum CRP, IL-6, TNF-alpha, homocysteine, folic acid and vitamin B12 levels with the severity of preeclampsia and fetal birth weight.
Topics: Adult; Biomarkers; Birth Weight; C-Reactive Protein; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Infant, Low Birth Weight; Infant, Newborn; Interleukin-6; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Tumor Necrosis Factor-alpha; Vitamin B 12; Young Adult | 2009 |
Effects of a low-protein diet on plasma amino acid and homocysteine levels and oxidative status in rats.
Topics: Amino Acids; Animals; Blood Proteins; Body Weight; Creatinine; Diet; Diet, Protein-Restricted; Folic Acid; Glutathione; Homocysteine; Lipid Peroxidation; Liver; Male; Organ Size; Oxidative Stress; Rats; Rats, Wistar; Regression Analysis; Vitamin B 12 | 2009 |
Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction.
Topics: Adult; Embryo, Mammalian; Estradiol; Female; Folic Acid; Follicle Stimulating Hormone; Follicular Fluid; Homocysteine; Humans; Infertility, Female; Malondialdehyde; Oocytes; Ovulation Induction; Polycystic Ovary Syndrome; Reproductive Techniques, Assisted; Vitamin B 12 | 2009 |
Homocysteine and cognitive impairment in Parkinson's disease: a biochemical, neuroimaging, and genetic study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Aged, 80 and over; Brain; Carbon-Nitrogen Ligases; Case-Control Studies; Cognition Disorders; Cystathionine beta-Synthase; Depression; Female; Folic Acid; Homocysteine; Humans; Immunoassay; Logistic Models; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Parkinson Disease; Polymorphism, Genetic; Severity of Illness Index; Vitamin B 12; Vitamin B 6 | 2009 |
Telomere length in peripheral blood mononuclear cells is associated with folate status in men.
Topics: beta-Globins; Cellular Senescence; DNA; Folic Acid; Genotype; Homocysteine; Humans; Leukocytes, Mononuclear; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Single Nucleotide; RNA; Telomere; Vitamin B 12 | 2009 |
Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh.
Topics: Arsenic; Child; Cysteine; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Sex Factors; Vitamin B 12; Water Pollutants, Radioactive | 2009 |
Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B12 in the acute phase of atherothrombotic stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Brain Ischemia; Cysteine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Intracranial Thrombosis; Male; Middle Aged; Risk Factors; Stroke; Vitamin B 12; Vitamins | 2009 |
Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults.
Topics: Aged; Cross-Sectional Studies; Depression; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Risk Factors; Singapore; Vitamin B 12 | 2009 |
Role of thrombotic risk factors in end-stage renal disease.
Topics: 3' Untranslated Regions; Adult; Alleles; Amino Acid Substitution; Factor V; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Point Mutation; Prothrombin; Risk Factors; Thrombophilia; Vitamin B 12; Young Adult | 2010 |
Association between asymmetric dimethylarginine and neopterin in patients with and without angiographic coronary artery disease.
Topics: Arginine; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Middle Aged; Neopterin; Risk Factors; Vitamin B 12; Vitamin B 6 | 2009 |
Relationship between genetic polymorphism, serum folate and homocysteine in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2008 |
Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci.
Topics: Animals; Cell Proliferation; Colorectal Neoplasms; Dietary Supplements; Disease Progression; Folic Acid; Homocysteine; Liver; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2009 |
Pilot study of association of anembryonic pregnancy with 55 elements in the urine, and serum level of folate, homocysteine and S-adenosylhomocysteine in Shanxi Province, China.
Topics: Adult; Case-Control Studies; China; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Multivariate Analysis; Nutritional Status; Pilot Projects; Pregnancy; Pregnancy Outcome; S-Adenosylhomocysteine; Trace Elements; Urine; Young Adult | 2009 |
Homocysteine levels in patients with Behçet's disease and patients with recurrent aphthous stomatitis.
Topics: Adolescent; Adult; Behcet Syndrome; Biomarkers; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Recurrence; Stomatitis, Aphthous; Vitamin B 12; Young Adult | 2009 |
Folic acid supplementation and cardiovascular disease: the state of the art.
Topics: Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic | 2009 |
Association between plasma homocysteine levels and mortality in elderly patients with mental illness.
Topics: Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Kaplan-Meier Estimate; Kidney Function Tests; Male; Mental Disorders; Middle Aged; Proportional Hazards Models; Regression Analysis; Survival Analysis; Vascular Diseases; Vitamin B 12 | 2009 |
High-dose short-term folate administration modifies ambulatory blood pressure in postmenopausal women. A placebo-controlled study.
Topics: Aging; Blood Pressure; Cardiovascular Diseases; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Insulin; Middle Aged; Postmenopause; Vitamin B Complex | 2009 |
Serum levels of lipoprotein(a) and homocysteine in patients on hemodialysis who take hydroxymethylglutaryl-CoA reductase inhibitors, vitamin B6, and folic acid.
Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; Cardiovascular Diseases; Cross-Sectional Studies; Eating; Female; Folic Acid; Heptanoic Acids; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Failure, Chronic; Lipoprotein(a); Lovastatin; Male; Middle Aged; Pyrroles; Renal Dialysis; Risk Factors; Vitamin B 6; Vitamin B Complex; Young Adult | 2009 |
The relationship between homocysteine and genes of folate-related enzymes in migraine patients.
Topics: Adult; Algorithms; DNA Mutational Analysis; Epigenesis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Migraine Disorders; Migraine with Aura; Polymorphism, Genetic; Sex Characteristics; Sex Factors; Thymidylate Synthase | 2010 |
Acute homocysteine administration impairs memory consolidation on inhibitory avoidance task and decreases hippocampal brain-derived neurotrophic factor immunocontent: prevention by folic acid treatment.
Topics: Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Folic Acid; Hippocampus; Homocysteine; Hyperhomocysteinemia; Memory; Memory Disorders; Memory, Short-Term; Motor Activity; Parietal Lobe; Random Allocation; Rats; Rats, Wistar; Time Factors; Vitamin B Complex | 2009 |
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.
Topics: Adult; Chemokine CCL2; Female; Folic Acid; Genotype; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Sex Factors; Young Adult | 2009 |
An investigation of vitamin B12 deficiency in elderly inpatients in neurology department.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Anemia, Megaloblastic; Electrophysiology; Female; Folic Acid; Geriatric Assessment; Homocysteine; Humans; Male; Middle Aged; Neurologic Examination; Neuropsychological Tests; Nutritional Status; Prevalence; Retrospective Studies; Risk Factors; Sex Factors; Statistics as Topic; Vitamin B 12; Vitamin B 12 Deficiency | 2009 |
The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women.
Topics: Adolescent; Adult; Child; Erythrocytes; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Membrane Transport Proteins; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Sex Characteristics; Young Adult | 2009 |
Plasma vitamin B(6) and risk of myocardial infarction in women.
Topics: Adult; Alcohol Drinking; Body Mass Index; Case-Control Studies; Creatinine; Feeding Behavior; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Middle Aged; Myocardial Infarction; Nutrition Assessment; Prospective Studies; Pyridoxal Phosphate; Risk Factors; Vitamin B 6 | 2009 |
A New DiaSys colorimetric assay for plasma homocysteine: application in diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; C-Reactive Protein; Chromatography, High Pressure Liquid; Colorimetry; Diabetes Mellitus; Female; Folic Acid; Glomerular Filtration Rate; Glycated Hemoglobin; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Reproducibility of Results; Vitamin B 12 | 2009 |
Methylation status and neurodegenerative markers in Parkinson disease.
Topics: Aged; alpha-Synuclein; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Biomarkers; Blood Platelets; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Nerve Degeneration; Parkinson Disease; Peptide Fragments; S-Adenosylhomocysteine; S-Adenosylmethionine; Substantia Nigra; Ultrasonography; Vitamin B 6 | 2009 |
Effects of folic acid and homocysteine on spinal cord morphology of the chicken embryo.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Proliferation; Chick Embryo; Folic Acid; Homocysteine; Mesenchymal Stem Cells; Neural Cell Adhesion Molecules; Spinal Cord | 2009 |
Folate content in different strawberry genotypes and folate status in healthy subjects after strawberry consumption.
Topics: Adult; Biomarkers; Eating; Female; Folic Acid; Fragaria; Genotype; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Pilot Projects; Reference Values; Vitamin B 12; Young Adult | 2008 |
Homocysteine and endothelial markers are increased in patients with chronic liver diseases.
Topics: Adult; Aged; Blood Coagulation Factors; Case-Control Studies; Chronic Disease; Endothelium, Vascular; Fatty Liver; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Cirrhosis; Male; Middle Aged; Prothrombin Time | 2009 |
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Valproic Acid; Vitamin B 12 | 2009 |
Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Transcobalamins; Vitamin B 12 Deficiency | 2009 |
Impact of homocysteine-lowering vitamin therapy on long-term outcome of patients with coronary artery disease.
Topics: Adult; Coronary Artery Disease; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Survival Analysis; Treatment Outcome; Vitamin B Complex | 2009 |
LINE-1 DNA methylation is inversely correlated with cord plasma homocysteine in man: a preliminary study.
Topics: DNA Methylation; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Long Interspersed Nucleotide Elements; Pregnancy | 2009 |
Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals.
Topics: Adolescent; Adult; Alleles; Female; Folic Acid; Genotype; Health Status; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Turkey; Vitamin B 12; Young Adult | 2009 |
Increases in plasma holotranscobalamin can be used to assess vitamin B-12 absorption in individuals with low plasma vitamin B-12.
Topics: Adult; Body Height; Body Weight; Cardiovascular Diseases; Child; Diabetes Mellitus, Type 2; Fathers; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Intestinal Absorption; Male; Maternal Nutritional Physiological Phenomena; Mother-Child Relations; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2009 |
The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber.
Topics: Aged; Aging; Arterioles; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Photography; Retinal Artery; Retinal Vein; Sex Factors; Smoking; Venules; Vitamin B 12 | 2009 |
The association between high plasma homocysteine levels and lower bone mineral density in Slovak women: the impact of vegetarian diet.
Topics: Adult; Age Distribution; Aged; Albumins; Blood Glucose; Bone Density; Calcium; Causality; Cohort Studies; Creatinine; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Phosphorus; Risk Factors; Slovakia; Vitamin B 12; Young Adult | 2010 |
One-carbon metabolism-genome interactions in folate-associated pathologies.
Topics: Animals; Carbon; Child; Developmental Disabilities; Disease Models, Animal; Environment; Folic Acid; Gastrointestinal Neoplasms; Genetic Phenomena; Genome, Human; Homocysteine; Humans; Methionine; Mice; Neural Tube Defects; Purines; Risk Factors; Thymidine Monophosphate | 2009 |
Body mass index is an important determinant of methylation biomarkers in women of reproductive ages.
Topics: Adult; Biomarkers; Body Mass Index; Female; Fertility; Folic Acid; Homocysteine; Humans; Life Style; Methylation; Middle Aged; Multivariate Analysis; Netherlands; S-Adenosylhomocysteine; S-Adenosylmethionine; Surveys and Questionnaires; Vitamin B 12; Young Adult | 2009 |
Folate status of Ghanaian populations in London and Accra.
Topics: Adult; Black People; Educational Status; Erythrocytes; Fasting; Female; Folic Acid; Ghana; Guinea; Homocysteine; Humans; Incidence; Male; Methylenetetrahydrofolate Dehydrogenase (NAD+); Polymorphism, Single Nucleotide; Smoking; Stroke; Urban Population; Vitamin B 12 | 2010 |
Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2006.
Topics: Adult; Aged; Demography; Diet; Dietary Supplements; Energy Intake; Ethnicity; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Interviews as Topic; Male; Memory; Middle Aged; Nutrition Surveys; Racial Groups; United States; Vitamin B 12; Young Adult | 2010 |
Folic acid, vitamin B12, and homocysteine levels during fasting and after methionine load in patients with Type 1 diabetes mellitus.
Topics: Adolescent; Adult; Aging; Blood Glucose; Case-Control Studies; Child; Diabetes Mellitus, Type 1; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Sex Characteristics; Vitamin B 12; Young Adult | 2010 |
Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria.
Topics: Adult; Ambulatory Care Facilities; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Methylmalonic Acid; Nigeria; Pregnancy; Pregnancy Complications; Prenatal Care; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2009 |
A clinical puzzle: fibrates and homocysteine elevation: editorial to: "fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine" by M. Lever et al.
Topics: Animals; Betaine; Bezafibrate; Clofibric Acid; Dyslipidemias; Folic Acid; Homocysteine; Humans; Hypolipidemic Agents; Metabolic Syndrome | 2009 |
Hyperhomocysteinaemia, low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis.
Topics: Acute Disease; Adult; Aged; Asian People; Biomarkers; Case-Control Studies; Chi-Square Distribution; China; Chromatography, High Pressure Liquid; Down-Regulation; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Immunoassay; Male; Mesenteric Vascular Occlusion; Mesenteric Veins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Odds Ratio; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Risk Assessment; Risk Factors; Venous Thrombosis; Vitamin B 12; Young Adult | 2010 |
Determinants of homocysteine levels in colorectal and breast cancer patients.
Topics: Adult; Breast Neoplasms; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Homocysteine; Humans; Inflammation Mediators; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Status; Polymorphism, Single Nucleotide | 2009 |
Double aneuploidy (48,XXY,+21) of maternal origin in a child born to a 13-year-old mother: evaluation of the maternal folate metabolism.
Topics: Adolescent; Alleles; Aneuploidy; Brazil; Chromosomes, Human, X; Chromosomes, Human, Y; DNA Mutational Analysis; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Carrier Screening; Genotype; Heart Defects, Congenital; Homocysteine; Homozygote; Humans; Infant; Klinefelter Syndrome; Male; Meiosis; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Nondisjunction, Genetic; Polymorphism, Genetic; Pregnancy; Pregnancy in Adolescence; Sex Chromosome Aberrations; Trisomy | 2009 |
Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men.
Topics: Adult; Aged; Ankle; Ankle Brachial Index; Asian People; Atherosclerosis; Blood Flow Velocity; Blood Glucose; Blood Pressure; Brachial Artery; C-Reactive Protein; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipoproteins, LDL; Male; Middle Aged; Tumor Necrosis Factor-alpha; Vascular Resistance; Vitamin B 12 | 2011 |
Does high folic acid intake affect unrecognized cobalamin deficiency, and how will we know it if we see it?
Topics: Cognition; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 2009 |
Observational study on markers of cardiovascular risk in renal patient: conventional hemodialysis vs. haemofiltration online.
Topics: Biomarkers; Cardiovascular Diseases; Chi-Square Distribution; Cross-Sectional Studies; Female; Folic Acid; Hemodiafiltration; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Obesity; Online Systems; Renal Dialysis; Risk Assessment; Risk Factors; Treatment Outcome; Vitamin B 12 | 2009 |
Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.
Topics: Adult; Atherosclerosis; Blood Glucose; Brachial Artery; Cholesterol; DNA; Endothelium, Vascular; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Insulin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Statistics, Nonparametric; Triglycerides; Ultrasonography, Doppler | 2010 |
Serum folate is a reliable indicator of hyperhomocysteinemia and borderline hyperhomocysteinemia in young adults.
Topics: Adolescent; Adult; Area Under Curve; Biomarkers; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Pyridoxal Phosphate; Reference Values; Risk Factors; Severity of Illness Index; Taiwan; Vitamin B 12; Young Adult | 2009 |
Relationship between plasma folate and homocysteine concentrations in alcoholics according to liver enzyme activity.
Topics: Adult; Aged; Alanine Transaminase; Alcoholics; Alcoholism; Aspartate Aminotransferases; Biomarkers; Case-Control Studies; Folic Acid; gamma-Glutamyltransferase; Homocysteine; Humans; Liver; Liver Diseases; Male; Middle Aged; Reference Values; Young Adult | 2009 |
Enhanced one-carbon flux towards DNA methylation: Effect of dietary methyl supplements against gamma-radiation-induced epigenetic modifications.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon; Choline; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gamma Rays; Homocysteine; Male; Mice; S-Adenosylmethionine; Time Factors | 2010 |
Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome.
Topics: Adult; Body Mass Index; Brachial Artery; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Exercise; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Leisure Activities; Metformin; Placebos; Polycystic Ovary Syndrome; Tunica Intima; Tunica Media; Vasodilation; Vitamin B 12; Waist-Hip Ratio | 2010 |
The maternal homocysteine pathway is influenced by riboflavin intake and MTHFR polymorphisms without affecting the risk of orofacial clefts in the offspring.
Topics: Biomarkers; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linear Models; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); Nutrigenomics; Odds Ratio; Polymorphism, Genetic; Riboflavin; Risk Factors; Surveys and Questionnaires; Vitamin B 12 | 2010 |
Homocysteine induces hypophosphorylation of intermediate filaments and reorganization of actin cytoskeleton in C6 glioma cells.
Topics: Actins; Animals; Antioxidants; Ascorbic Acid; Cell Line; Chromans; Cytoskeleton; Excitatory Amino Acid Agonists; Folic Acid; Glial Fibrillary Acidic Protein; Homocysteine; Intermediate Filaments; Neuroglia; Phosphorylation; Rats; Vimentin; Vitamin B Complex | 2010 |
Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.
Topics: Adult; Analysis of Variance; Erythrocytes; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Interleukin-6; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Predictive Value of Tests; Risk Factors; Schizophrenia; Tumor Necrosis Factor-alpha; Young Adult | 2010 |
Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle.
Topics: Animals; Appetite Regulation; Caseins; Diet, Protein-Restricted; Dietary Fats; Dietary Supplements; DNA Methylation; Enzymes; Female; Folic Acid; Food Preferences; Glutathione; Homocysteine; Male; Methionine; Placentation; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Rats; Rats, Wistar; RNA, Messenger; Vitamin B Complex | 2010 |
Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women.
Topics: Alkaline Phosphatase; Biomarkers; Bone Density; Collagen Type I; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Peptides; Postmenopause; Vitamin B 12 | 2010 |
Methyl donor deficiency affects fetal programming of gastric ghrelin cell organization and function in the rat.
Topics: Animals; Body Weight; Cell Lineage; Choline; Deficiency Diseases; Enteroendocrine Cells; Female; Fetal Development; Folic Acid; Gastric Mucosa; Ghrelin; Growth Hormone; Homocysteine; Immunohistochemistry; Pregnancy; Rats; Rats, Wistar; Vitamin B 12; Weaning | 2010 |
Hyperhomocysteinemia in patients with stasis dermatitis and ulcer: a novel finding with important therapeutic implications.
Topics: Adult; Biomarkers; Case-Control Studies; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Leg Dermatoses; Male; Middle Aged; Severity of Illness Index; Treatment Outcome; Varicose Ulcer; Vitamin B Complex | 2009 |
Quantification of key folate forms in serum using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adolescent; Adult; Carbon Isotopes; Chromatography, High Pressure Liquid; Drug Stability; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tetrahydrofolates | 2010 |
Determination of serum holotranscobalamin concentrations with the AxSYM active B(12) assay: cut-off point evaluation in the clinical laboratory.
Topics: Aged; Biomarkers; Blood Chemical Analysis; Female; Folic Acid; Homocysteine; Humans; Immunoenzyme Techniques; Male; Middle Aged; Sensitivity and Specificity; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2010 |
Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism.
Topics: Adolescent; Adult; Case-Control Studies; Docosahexaenoic Acids; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hydrocortisone; Male; Psychiatric Status Rating Scales; Schizophrenia; Vitamin B 12; Young Adult | 2010 |
One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study.
Topics: Aged; Carbon; Case-Control Studies; Colorectal Neoplasms; CpG Islands; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Incidence; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Sweden; Vitamin B 12 | 2010 |
Obesity and insulin resistance associated with lower plasma vitamin B12 in PCOS.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; Obesity; Polycystic Ovary Syndrome; Vitamin B 12 | 2009 |
Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aging; Autoimmune Diseases; CD27 Ligand; CD28 Antigens; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Modification Methylases; Female; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Male; Methionine; Micronutrients; Middle Aged; Receptors, KIR; T-Lymphocytes | 2010 |
Expression of folate transporters in human placenta and implications for homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Carrier Proteins; Cell Membrane; Cell Polarity; Cystathionine beta-Synthase; Female; Fluorescent Antibody Technique, Indirect; Folate Receptors, GPI-Anchored; Folic Acid; Homocysteine; Humans; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Placenta; Pregnancy; Pregnancy Proteins; Pregnancy Trimester, First; Protein Transport; Proton-Coupled Folate Transporter; Receptors, Cell Surface; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Term Birth; Trophoblasts | 2010 |
Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways.
Topics: Adult; Creatinine; Cysteine; Erythrocytes; Female; Folic Acid; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Middle Aged; Models, Biological; Multivariate Analysis; Pancreatitis, Alcoholic; Pancreatitis, Chronic; Regression Analysis; Signal Transduction; Sulfates; Sulfur; Young Adult | 2010 |
677C>T and 1298A>C polymorphisms of methylenetetrahydropholate reductase gene and biochemical parameters in Turkish population with spina bifida occulta.
Topics: Adenine; Case-Control Studies; Cytosine; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Reference Values; Spina Bifida Occulta; Thymine; Turkey; Vitamin B 12 | 2010 |
Validity of brief food frequency questionnaire for estimation of dietary intakes of folate, vitamins B6 and B12, and their associations with plasma homocysteine concentrations.
Topics: Adult; Diet; Diet Surveys; Female; Folic Acid; Homocysteine; Humans; Japan; Male; Middle Aged; Nutrition Assessment; Reproducibility of Results; Statistics, Nonparametric; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2010 |
Serum folate and homocysteine and depressive symptoms among Japanese men and women.
Topics: Adult; Aged; Cross-Sectional Studies; Depression; Female; Folic Acid; Health Status; Health Surveys; Homocysteine; Humans; Japan; Logistic Models; Male; Middle Aged; Multivariate Analysis; Nutritional Status; Odds Ratio; Prevalence; Sex Factors; Young Adult | 2010 |
Effect of the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods.
Topics: Beverages; Child; Cross-Sectional Studies; Diet; Edible Grain; Female; Folic Acid; Food, Fortified; Fruit; Genotype; Greece; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vitamin B Complex | 2010 |
Increased serum concentrations of homocysteine and lipoprotein (a) in familial Mediterranean fever.
Topics: Adult; Blood Sedimentation; C-Reactive Protein; Familial Mediterranean Fever; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Lipoprotein(a); Male; Prognosis; Young Adult | 2010 |
Homocysteine and pro-inflammatory cytokine concentrations in acute heart disease.
Topics: Cardiovascular Diseases; Case-Control Studies; Demography; Folic Acid; Homocysteine; Humans; Inflammation; Interleukin-2; Interleukin-6; Middle Aged; ROC Curve; Vitamin B 12 | 2010 |
Moderate or supranormal folic acid supplementation does not exert a protective effect for homocysteinemia and methylation markers in growing rats.
Topics: Analysis of Variance; Animals; Biomarkers; Chromatography, High Pressure Liquid; Diet; Dietary Supplements; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Glutathione; Homocysteine; Male; Methionine; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2010 |
The TCN2 776CNG polymorphism correlates with vitamin B(12) cellular delivery in healthy adult populations.
Topics: Adult; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Transcobalamins; Vitamin B 12 | 2010 |
Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse.
Topics: Animals; Folic Acid; Gene Deletion; Homocysteine; Intestinal Absorption; Leucovorin; Male; Mice; Multidrug Resistance-Associated Proteins; Tetrahydrofolates; Vitamin B 12 | 2010 |
Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients.
Topics: Adolescent; Adult; Antioxidants; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Middle Aged; Multiple Sclerosis; Triglycerides; Uric Acid; Vitamins | 2010 |
Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Cognition Disorders; Dementia, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Oxidation-Reduction | 2010 |
Plasma homocysteine levels in patients with normal tension glaucoma.
Topics: Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Immunoassay; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2010 |
Magnetic resonance angiography findings in patients with ischemic stroke from North India.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Biomarkers; Blood Glucose; Body Mass Index; Brain Ischemia; Carotid Artery, External; Carotid Artery, Internal; Diabetes Mellitus; Feeding Behavior; Female; Folic Acid; Homocysteine; Humans; Hypertension; India; Lipids; Magnetic Resonance Angiography; Male; Middle Aged; Racial Groups; Risk Factors; Socioeconomic Factors; Stroke; Vitamin B 12; Young Adult | 2010 |
Comment on: Song et al. (2009) Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial. Diabetes 58:1921-1928.
Topics: Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B Complex | 2010 |
Plasma homocysteine and cysteine and risk of breast cancer in women.
Topics: Breast Neoplasms; Case-Control Studies; Cysteine; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Prospective Studies; Pyridoxal Phosphate; Vitamin B 12 | 2010 |
[Plasma levels of folate and vitamin B(12) in patients with chronic liver disease].
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Diagnosis, Differential; Erythrocyte Indices; Female; Folic Acid; Folic Acid Deficiency; gamma-Glutamyltransferase; Homocysteine; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Liver Failure; Liver Function Tests; Male; Middle Aged; Prognosis; Prospective Studies; Vitamin B 12; Young Adult | 2010 |
Fasting and post-methionine homocysteine levels in Alzheimers disease and vascular dementia.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cohort Studies; Dementia, Vascular; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Statistics, Nonparametric; Vitamin B 12 | 2009 |
[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries].
Topics: Alleles; Atherosclerosis; DNA; Female; Ferredoxin-NADP Reductase; Flavoproteins; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Leg; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Prognosis; Severity of Illness Index | 2009 |
Total homocysteine in patients with angiographic coronary artery disease correlates with inflammation markers.
Topics: Aged; Biomarkers; C-Reactive Protein; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Creatinine; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Inflammation Mediators; Male; Middle Aged; Neopterin; Vitamin B 12 | 2010 |
Folate bioavailability: implications for establishing dietary recommendations and optimizing status.
Topics: Adolescent; Adult; Biological Availability; Dietary Supplements; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Intestinal Absorption; Methionine; Middle Aged; Nutrition Policy; Nutritional Requirements; Premenopause; Young Adult | 2010 |
Are dietary choline and betaine intakes determinants of total homocysteine concentration?
Topics: Betaine; Cardiovascular Diseases; Choline; Cognition Disorders; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Vitamin B 12; Vitamin B 6 | 2010 |
MTHFR gene polymorphism and its relationship with plasma homocysteine and folate in a North Indian population.
Topics: Adolescent; Adult; Age Factors; Aged; DNA Mutational Analysis; Feeding Behavior; Female; Folic Acid; Genetics, Population; Homocysteine; Humans; India; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Vitamin B 12; Young Adult | 2010 |
Prevalence of hyperhomocysteinaemia in a Chinese elderly population.
Topics: Aged; Alcohol Drinking; China; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male; Prevalence; Sex Factors; Surveys and Questionnaires; Vitamin B 12 | 2010 |
Vitamin and mineral status in elderly patients with chronic obstructive pulmonary disease.
Topics: Aged; Aged, 80 and over; Calcium; Diet; Dietary Proteins; Energy Intake; Fatty Acids; Fatty Acids, Unsaturated; Female; Folic Acid; Homocysteine; Humans; Interviews as Topic; Male; Malonates; Minerals; Osteoporosis; Pulmonary Disease, Chronic Obstructive; Vitamin D; Vitamins | 2007 |
Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine.
Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Cisterna Magna; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Homocysteine; Inflammation Mediators; Injections, Spinal; Male; Memory Disorders; Methotrexate; Motor Activity; Neuropsychological Tests; Psychomotor Performance; Rats; Rats, Long-Evans; Recognition, Psychology; Time Factors | 2010 |
Decreased level of 5-methyltetrahydrofolate: a potential biomarker for pre-symptomatic amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Chromatography, Liquid; Disease Models, Animal; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Mice; Mice, Transgenic; Severity of Illness Index; Statistics as Topic; Superoxide Dismutase; Tandem Mass Spectrometry; Tetrahydrofolates; Time Factors | 2010 |
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate.
Topics: Adult; Aged; Boston; Cardiovascular Diseases; Cognition Disorders; DNA Damage; Female; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Hypertension; Life Style; Male; Memory; Methionine Adenosyltransferase; Middle Aged; Puerto Rico; Stroke; Vitamin B 6 | 2010 |
Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Bone Density; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Osteoarthritis, Hip; Vitamin B 12; Vitamin B 6 | 2010 |
Effect of highly active antiretroviral therapy on homocysteine plasma concentrations in HIV-1-infected patients.
Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Erythrocytes; Female; Folic Acid; HIV Infections; HIV-1; Homocysteine; Humans; Male; Metabolic Diseases; Middle Aged; Plasma; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2010 |
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors.
Topics: Aged; Aging; Anemia; Anemia, Macrocytic; Blood Cell Count; Cognition; Cognition Disorders; Cystatin C; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Linear Models; Male; Methylmalonic Acid; Multivariate Analysis; Nutrition Surveys; Tetrahydrofolates; United States; Vitamin B 12 Deficiency | 2010 |
Major determinants of serum homocysteine concentrations in a Korean population.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Odds Ratio; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Young Adult | 2010 |
Plasma homocysteine--a marker of vascular disease in elderly patients with mental illness.
Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Female; Folic Acid; Homocysteine; Humans; Kidney; Logistic Models; Male; Mental Disorders; Middle Aged; Predictive Value of Tests; Vascular Diseases; Vitamin B 12 | 2010 |
[Vitamin B12 concentration in the blood of alcoholics].
Topics: Adult; Aged; Alcoholism; Biomarkers; Folic Acid; Homocysteine; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Reference Values; Vitamin B 12 | 2010 |
A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma.
Topics: Biomarkers; Carbon; Carcinoma, Renal Cell; Case-Control Studies; Chromatography, High Pressure Liquid; Cysteine; Folic Acid; Homocysteine; Humans; Kidney Neoplasms; Logistic Models; Male; Middle Aged; Prospective Studies; Riboflavin; Risk Assessment; Risk Factors; Vitamin B 12; Vitamin B 6 | 2010 |
Deficiencies of folate and vitamin B12 do not affect fracture healing in mice.
Topics: Animals; Biomechanical Phenomena; Body Weight; Bony Callus; Femoral Fractures; Folic Acid; Folic Acid Deficiency; Fracture Healing; Homocysteine; Mice; Radiography; Vitamin B 12; Vitamin B 12 Deficiency | 2010 |
Dietary intake of vitamins B6, B12 and folate in relation to homocysteine serum concentration in the adult Polish population - WOBASZ Project.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Nutrition Policy; Poland; Population Surveillance; Vitamin B 12; Vitamin B 6; Young Adult | 2010 |
Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes.
Topics: Biomarkers; Chi-Square Distribution; Dietary Supplements; Drug Administration Schedule; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Israel; Linear Models; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Nutrigenomics; Odds Ratio; Phenotype | 2010 |
Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia.
Topics: Age Factors; Aged, 80 and over; Aging; Black or African American; Erythrocytes; Female; Folic Acid; Georgia; Homocysteine; Humans; Male; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency; White People | 2010 |
Homocysteine, vitamin B12 and folate levels in Iranian patients with ischemic stroke.
Topics: Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Iran; Male; Middle Aged; Stroke; Vitamin B 12 | 2010 |
Relationship between the Levels of Holotranscobalamin and Vitamin B12.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2010 |
Homocysteine and oxidative stress in Egyptian children with Down syndrome.
Topics: Adult; Ascorbic Acid; Child; Child, Preschool; Copper; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Male; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Tocopherols; Zinc | 2010 |
A study on thrombophilic factors in Italian Behcet's patients.
Topics: Adult; Antibodies, Antiphospholipid; Antithrombins; Behcet Syndrome; Case-Control Studies; Factor V; Female; Folic Acid; Homocysteine; Humans; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Protein C; Prothrombin; Receptors, Lipoprotein; Risk Factors; Thrombosis | 2010 |
Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma.
Topics: Aged; Chromatography, High Pressure Liquid; Female; Folic Acid; Glaucoma, Open-Angle; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2010 |
Plasma homocysteine in schizophrenia: determinants and clinical correlations in Tunisian patients free from antipsychotics.
Topics: Adult; Dementia; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Psychiatric Status Rating Scales; Psychometrics; Retrospective Studies; Schizophrenia; Statistics as Topic; Tunisia; Vitamin B 12 | 2010 |
Increased levels of homocysteine in patients with ulcerative colitis.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Chi-Square Distribution; Colitis, Ulcerative; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Risk Assessment; Risk Factors; Thromboembolism; Up-Regulation; Vitamin B 12; Young Adult | 2010 |
Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation.
Topics: Adult; Birth Weight; Female; Fetal Blood; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Gestational Age; Homocysteine; Humans; Infant, Newborn; Infant, Small for Gestational Age; Mothers; Predictive Value of Tests; Pregnancy; Premature Birth; Vitamin B 12 | 2010 |
[Homocysteine as a residual risk factor in cardiovascular diseases].
Topics: Biomarkers; Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Risk Factors; Vitamin B 12; Vitamin B 6 | 2010 |
Methylenetetrahydrofolate reductase C677T gene mutation as risk factor for sudden sensorineural hearing loss: association with plasma homocysteine, folate and cholesterol concentrations.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Child; Cholesterol; Cochlea; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Hearing Loss, Sensorineural; Hearing Loss, Sudden; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Risk Factors; Young Adult | 2010 |
Homocysteine and folic acid levels in hemodialysis patients treated with sevelamer hydrochloride.
Topics: Chelating Agents; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Polyamines; Renal Dialysis; Sevelamer | 2010 |
Contribution of dietary intakes of antioxidants to homocysteine-induced low density lipoprotein (LDL) oxidation in atherosclerotic patients.
Topics: Adult; Aged; Antioxidants; Atherosclerosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Risk Factors; Vitamin B 12; Vitamin B Complex | 2010 |
S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Apolipoprotein E4; Chi-Square Distribution; Cross-Sectional Studies; Fasting; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Mental Status Schedule; Middle Aged; S-Adenosylmethionine; White People | 2010 |
Effect of lipopenic and hypotensive treatment on homocysteine levels in type 2 diabetics.
Topics: Aged; Antihypertensive Agents; Biomarkers; Case-Control Studies; Chi-Square Distribution; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypolipidemic Agents; Male; Middle Aged; Odds Ratio; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Triglycerides; Vitamin B 12 | 2010 |
Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Arsenic; Cacodylic Acid; Carcinoma, Transitional Cell; Case-Control Studies; Cystathionine beta-Synthase; Female; Folic Acid; Genotype; Homocysteine; Humans; Life Style; Male; Metabolic Networks and Pathways; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Socioeconomic Factors; Taiwan; Urinary Bladder Neoplasms | 2010 |
Determinants of homocysteine levels in Ivorian rural population.
Topics: Adult; Aged; C-Reactive Protein; Cholesterol; Cote d'Ivoire; Creatinine; Feeding Behavior; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Rural Population; Serum Albumin; Statistics, Nonparametric; Triglycerides; Vitamin B 12; Young Adult | 2009 |
Homocysteine status and cardiovascular risk factors in patients with psoriasis: a case-control study.
Topics: Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Psoriasis; Risk Factors; Severity of Illness Index; Vitamin B 12 | 2011 |
Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United States.
Topics: Aged; Diet; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Nutrition Surveys; Tetrahydrofolates; United States; Vitamin B 12 | 2010 |
Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss.
Topics: Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Female; Folic Acid; Health Surveys; Hearing Loss; Homocysteine; Humans; Male; Multivariate Analysis; Odds Ratio; Vitamin B 12 | 2010 |
C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects.
Topics: Adult; Alleles; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Turkey; Vitamin B 12 | 2010 |
Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China.
Topics: Adult; Alleles; China; Colitis, Ulcerative; DNA; Female; Folic Acid; Folic Acid Deficiency; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Immunoenzyme Techniques; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Polymorphism, Genetic; Prevalence; Vitamin B 12 | 2010 |
Vitamin B-12 status is not associated with plasma homocysteine in parents and their preschool children: lacto-ovo, lacto, and ovo vegetarians and omnivores.
Topics: Adult; Child; Child, Preschool; Diet; Diet Records; Diet, Vegetarian; Female; Folic Acid; Homocysteine; Humans; Male; Nutritional Status; Vitamin B 12 | 2010 |
The relationship between plasma homocysteine levels and bone mineral density in post-menopausal women.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Body Mass Index; Bone Density; Chi-Square Distribution; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Italy; Linear Models; Menopause; Middle Aged; Osteoporosis; Vitamin B 12 | 2010 |
Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Matched-Pair Analysis; Methylmalonic Acid; Middle Aged; Parkinson Disease; Reference Values; Supranuclear Palsy, Progressive; Vitamin B 12 | 2010 |
Homocysteine, red cell, and plasma folate concentrations and birth weight in Italian women: results from a prospective study.
Topics: Adult; Birth Weight; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Gestational Age; Homocysteine; Humans; Infant, Newborn; Italy; Osmolar Concentration; Plasma; Pregnancy; Prospective Studies; Young Adult | 2011 |
Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study.
Topics: Aged, 80 and over; alpha-Tocopherol; Cognition; Cross-Cultural Comparison; Female; Folic Acid; gamma-Tocopherol; Homocysteine; Humans; Japan; Male; Micronutrients; Oregon; Pilot Projects; Potassium; Sodium; Vitamin B 12 | 2010 |
Association between adherence to folic acid supplements and serum folate, and plasma homocysteine among hemodialysis patients.
Topics: Administration, Oral; Adult; Aged; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Multicenter Studies as Topic; Patient Compliance; Randomized Controlled Trials as Topic; Renal Dialysis; Vitamin B 12; Vitamin B 6 | 2011 |
Oxidative stress is increased in primary and post-polycythemia vera myelofibrosis.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Chronic Disease; Female; Folic Acid; Homocysteine; Humans; Janus Kinase 2; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidative Stress; Polycythemia Vera; Polymorphism, Single Nucleotide; Primary Myelofibrosis; Reactive Oxygen Species; Transcobalamins; Vitamin B 12 | 2010 |
Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan.
Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lead; Male; Middle Aged; Pakistan; Pyridoxal Phosphate; Young Adult | 2010 |
Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China.
Topics: Aged; Aged, 80 and over; Aging; Cognition; Cognition Disorders; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Vitamin B 12; Vitamin B 6; Vitamins | 2010 |
Relation of plasma total homocysteine, folate and vitamin B12 levels to bone mineral density in Moroccan healthy postmenopausal women.
Topics: Absorptiometry, Photon; Age Factors; Aged; Body Mass Index; Bone Density; Bone Diseases, Metabolic; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Lumbar Vertebrae; Middle Aged; Morocco; Osteoporosis, Postmenopausal; Parathyroid Hormone; Postmenopause; Retrospective Studies; Risk Factors; Vitamin B 12 | 2012 |
Seminal plasma homocysteine, folate and cobalamin in men with obstructive and non-obstructive azoospermia.
Topics: Adult; Azoospermia; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Humans; Luminescence; Male; Semen; Statistics, Nonparametric; Vitamin B 12 | 2010 |
Could genetic analysis be useful in reducing cerebrovascular risk in hypertensive subjects with hyperhomocysteinemia and patent foramen ovale? A 2-year follow-up study.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Blood Pressure; Cerebrovascular Disorders; Chi-Square Distribution; Echocardiography, Transesophageal; Female; Folic Acid; Follow-Up Studies; Foramen Ovale, Patent; Gene Frequency; Genetic Predisposition to Disease; Heterozygote; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Hypertension; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymorphism, Genetic; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial; Vitamins; Young Adult | 2010 |
Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure.
Topics: Case-Control Studies; Chemokine CCL2; Cholesterol, Dietary; Energy Intake; Female; Folic Acid; gamma-Glutamyltransferase; Heart Failure; Hematinics; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Surveys and Questionnaires | 2011 |
Association of omega-3 fatty acids and homocysteine concentrations in pre-eclampsia.
Topics: Adult; Erythrocytes; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Folic Acid; Homocysteine; Humans; India; Life Style; Pre-Eclampsia; Pregnancy; Prenatal Nutritional Physiological Phenomena; Prospective Studies; Surveys and Questionnaires; Vitamin B 12; Young Adult | 2011 |
Therapy: Vitamin B6, B9 and B12 in diabetic nephropathy--beware.
Topics: Cardiovascular Diseases; Diabetic Nephropathies; Disease Progression; Down-Regulation; Folic Acid; Homocysteine; Humans; Randomized Controlled Trials as Topic; Vitamin B 12; Vitamin B 6; Vitamins | 2010 |
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Carbon; Choline; Diet; Fatty Liver; Female; Ferredoxin-NADP Reductase; Folic Acid; Folic Acid Deficiency; Gene Expression; Homocysteine; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; RNA, Messenger; Sex Factors | 2010 |
Levels of plasma homocysteine in pseudoexfoliation glaucoma.
Topics: Aged; Exfoliation Syndrome; Female; Folic Acid; Glaucoma, Open-Angle; Homocysteine; Humans; Luminescent Measurements; Male; Vitamin B 12 | 2011 |
Human papilloma virus persistence and neopterin, folate and homocysteine levels in cervical dysplasias.
Topics: Adult; Alphapapillomavirus; Case-Control Studies; Female; Folic Acid; Homocysteine; Host-Pathogen Interactions; Humans; Immunity, Cellular; Neopterin; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 2011 |
Plasma homocysteine and cognition in elderly patients with dementia or other psychogeriatric diseases.
Topics: Aged; Aged, 80 and over; Cognition; Cognition Disorders; Creatinine; Dementia; Diagnostic and Statistical Manual of Mental Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Mental Disorders; Middle Aged; Neuropsychological Tests; Regression Analysis; Tomography, X-Ray Computed; Vascular Diseases; Vitamin B 12 | 2010 |
Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice.
Topics: Animals; Dietary Supplements; Folic Acid; Heart; Hematinics; Homocysteine; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Infarction; Myocytes, Cardiac; Neovascularization, Physiologic; Tissue Inhibitor of Metalloproteinases; Treatment Outcome; Ventricular Function, Left | 2010 |
Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Hyperhomocysteinemia; Nutritional Status; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Rural Population; Vitamin B 12; Vitamin B 12 Deficiency | 2010 |
Relationships between pregnancy outcomes, biochemical markers and pre-pregnancy body mass index.
Topics: Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Democratic People's Republic of Korea; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Obesity; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Risk Factors; Socioeconomic Factors; Weight Gain | 2011 |
Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals: a nationwide study.
Topics: Age Distribution; Analysis of Variance; Ethnicity; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hypercholesterolemia; Logistic Models; Male; Middle Aged; Risk Factors; Sex Distribution; Smoking; Stroke; Treatment Outcome | 2010 |
Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Exploratory Behavior; Female; Folic Acid; GABA Agents; Heterozygote; Homocysteine; Homocystinuria; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Muscle Spasticity; Phenotype; Psychotic Disorders; Receptors, GABA; Recognition, Psychology; Reflex; Sex Factors; Statistics, Nonparametric; Vigabatrin | 2011 |
Anemia in older persons.
Topics: Aged; Algorithms; Anemia; Deficiency Diseases; Erythrocyte Indices; Female; Ferritins; Folic Acid; Hematinics; Homocysteine; Humans; Inflammation; Iron Compounds; Male; Medical History Taking; Methylmalonic Acid; Physical Examination; Renal Insufficiency; Reticulocyte Count; Vitamin B 12 | 2010 |
Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Animals; Cardiomyopathies; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Diabetes Mellitus, Experimental; Folic Acid; Glucose; Glucose Transporter Type 4; Heart Failure; Homocysteine; Hyperglycemia; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardial Contraction; Myocytes, Cardiac; Receptors, Adrenergic, beta-2; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2010 |
Serum folate, vitamin B-12, and homocysteine and their association with depressive symptoms among U.S. adults.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Depression; Diagnostic and Statistical Manual of Mental Disorders; Female; Folic Acid; Health Status; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Nutrition Surveys; Poverty; Psychiatric Status Rating Scales; Severity of Illness Index; Sex Factors; Surveys and Questionnaires; United States; Vitamin B 12 | 2010 |
Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.
Topics: Aged; Biomarkers, Tumor; Disease Progression; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostate-Specific Antigen; Prostatic Neoplasms; Signal Transduction; Vitamin B 12 | 2010 |
Relationship between L-arginine/asymmetric dimethylarginine, homocysteine, folic acid, vitamin B levels, and coronary artery ectasia.
Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dilatation, Pathologic; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Turkey; Vitamin B Complex | 2010 |
Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans.
Topics: Birth Weight; CpG Islands; Epigenesis, Genetic; Female; Fetal Blood; Folic Acid; Gene Expression Profiling; Homocysteine; Humans; Long Interspersed Nucleotide Elements; Male; Neural Tube Defects; Pregnancy; Vitamin B Complex | 2011 |
Influence of the consumption of fruits and vegetables on the nutritional status of a group of institutionalized elderly persons in the Madrid region.
Topics: Aged; Aged, 80 and over; Body Mass Index; Cross-Sectional Studies; Diet; Diet Records; Erythrocytes; Female; Folic Acid; Fruit; Health Promotion; Homes for the Aged; Homocysteine; Humans; Institutionalization; Male; Nutritional Status; Patient Compliance; Spain; Vegetables | 2010 |
Commutability of National Institute of Standards and Technology standard reference material 1955 homocysteine and folate in frozen human serum for total folate with automated assays.
Topics: Folic Acid; Government Agencies; High-Throughput Screening Assays; Homocysteine; Humans; Linear Models; Reference Standards; United States | 2010 |
The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis.
Topics: Activated Protein C Resistance; Aged; Blood Coagulation Tests; Cohort Studies; Comorbidity; Factor V; Female; Folic Acid; Homocysteine; Homocystinuria; Hospital Mortality; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Muscle Spasticity; Point Mutation; Protein C; Psychotic Disorders; Respiration, Artificial; Sepsis; Shock, Septic; Thrombophilia; Vitamin B 12 | 2010 |
The vital amines: too much of a good thing?: comment on "Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality".
Topics: Cardiovascular Diseases; Cause of Death; Folic Acid; Homocysteine; Humans; Neoplasms; Randomized Controlled Trials as Topic; Stroke; Vitamin B Complex | 2010 |
Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study.
Topics: Absorptiometry, Photon; Adolescent; Biomarkers, Tumor; Bone Density; Case-Control Studies; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Fractures, Bone; Genotype; Germ Cells; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12 | 2011 |
Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study.
Topics: Aged; Aging; Alzheimer Disease; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Dementia; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Mental Status Schedule; Odds Ratio; Risk Factors; Transcobalamins | 2010 |
Prevention: B vitamins and CVD--failure to find a simple solution.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12; Vitamin B Complex | 2010 |
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility.
Topics: Case-Control Studies; DNA; Folic Acid; Genotype; Homocysteine; Humans; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Semen | 2011 |
[The relationship of methylenetetrahydrofolate reductase G1793A gene polymorphism, hyperhomocysteinaemia and ulcerative colitis].
Topics: Adult; Case-Control Studies; Colitis, Ulcerative; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Vitamin B 12 | 2010 |
Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre-eclampsia.
Topics: Adult; Case-Control Studies; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Nutritional Status; Placenta; Pre-Eclampsia; Pregnancy; Severity of Illness Index; Vitamin B 12 | 2011 |
Bisphosphonates in phenytoin-induced bone disorder.
Topics: Animals; Antioxidants; Biomarkers; Bone Density; Bone Diseases; Bone Remodeling; Diphosphonates; Dose-Response Relationship, Drug; Electroshock; Femur; Folic Acid; Homocysteine; Hydrogen Peroxide; Male; Mice; Phenytoin | 2011 |
Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsia.
Topics: Blood Pressure; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Hypertension; Infant, Newborn; Mothers; Placenta; Pre-Eclampsia; Pregnancy; Premature Birth; Term Birth; Vitamin B 12 | 2011 |
Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Female; Fluoresceins; Folic Acid; Heart Diseases; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Myocardium; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Reactive Nitrogen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2011 |
Contributions of enriched cereal-grain products, ready-to-eat cereals, and supplements to folic acid and vitamin B-12 usual intake and folate and vitamin B-12 status in US children: National Health and Nutrition Examination Survey (NHANES), 2003-2006.
Topics: Adolescent; Child; Child, Preschool; Dietary Supplements; Edible Grain; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Infant; Male; Methylmalonic Acid; Nutrition Surveys; Time Factors; Vitamin B 12 | 2011 |
Carbonyl proteins as a clinical marker in Alzheimer's disease and its relation to tryptophan degradation and immune activation.
Topics: Aged; Alzheimer Disease; Biomarkers; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neopterin; Oxidative Stress; Protein Carbonylation; Reference Values; Tryptophan; Vitamin B 12 | 2010 |
When the patient asks. Can folic acid lower heart attack risk?
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Myocardial Infarction; Risk Reduction Behavior | 2010 |
Effect of antioxidant vitamins on the plasma homocysteine level in a free-living elderly population.
Topics: Aged; Aging; Antioxidants; Ascorbic Acid; beta Carotene; Cardiovascular Diseases; Cross-Sectional Studies; Female; Folic Acid; Germany; Glomerular Filtration Rate; Homocysteine; Humans; Longitudinal Studies; Male; Vitamin E; Vitamins | 2010 |
19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism.
Topics: Adolescent; Chi-Square Distribution; Child; Cross-Sectional Studies; Down Syndrome; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Methylmalonic Acid; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Tetrahydrofolate Dehydrogenase | 2010 |
New insights on the lowest dose for mandatory folic acid fortification?
Topics: Folic Acid; Food, Fortified; Homocysteine; Humans; Neural Tube Defects | 2011 |
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Triglycerides; Valproic Acid; Vitamin B 12; Vitamin B Complex | 2011 |
Serum total homocystein, folate and vitamin B12 levels and their correlation with antipsychotic drug doses in adult male patients with chronic schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Case-Control Studies; Chlorpromazine; Chronic Disease; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Luminescent Measurements; Male; Middle Aged; Schizophrenia; Statistics, Nonparametric; Vitamin B 12 | 2010 |
Effect of cigarette smoking on plasma homocysteine concentrations.
Topics: Adult; Cotinine; Female; Folic Acid; Homocysteine; Humans; Male; Smoking; Thiocyanates; Vitamin B 12 | 2011 |
Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an ambulatory elderly population.
Topics: Age Factors; Aged; Aged, 80 and over; Ankle Brachial Index; Apolipoprotein A-I; Biomarkers; Cholesterol, HDL; Female; Folic Acid; Homocysteine; Humans; Independent Living; Male; Methylmalonic Acid; Middle Aged; Particle Size; Peripheral Arterial Disease; Regression Analysis; Risk Assessment; Risk Factors; Sicily; Vitamin B 12; Walking | 2011 |
Maternal and cord blood homocysteine and folic acid levels in smoking and nonsmoking pregnant women.
Topics: Adult; Female; Fetal Blood; Folic Acid; Gestational Age; Homocysteine; Humans; Luminescent Measurements; Pregnancy; Prenatal Exposure Delayed Effects; Smoking | 2011 |
Endothelial microparticle formation in moderate concentrations of homocysteine and methionine in vitro.
Topics: Apoptosis; Cell-Derived Microparticles; Endothelial Cells; Endothelium, Vascular; Flow Cytometry; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Umbilical Cord | 2011 |
Atherosclerotic and thrombophilic risk factors in patients with ischemic central retinal vein occlusion.
Topics: Acute Disease; Aged; Atherosclerosis; Biomarkers; Dyslipidemias; Factor VIII; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Ischemia; Male; Retinal Vein Occlusion; Risk Factors; Thrombophilia | 2011 |
A derangement of the maternal lipid profile is associated with an elevated risk of congenital heart disease in the offspring.
Topics: Adult; Apolipoproteins B; Body Mass Index; Case-Control Studies; Child; Cholesterol, LDL; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Hyperglycemia; Hyperhomocysteinemia; Logistic Models; Multivariate Analysis; Odds Ratio; Pregnancy; Pregnancy Complications, Cardiovascular; Risk Factors; Young Adult | 2012 |
Folate, vitamin B₁₂ and total homocysteine levels in Arab adolescent subjects: reference ranges and potential determinants.
Topics: Adolescent; Age Factors; Arabs; Biomarkers; Body Mass Index; Cardiovascular Diseases; Child; Cross-Sectional Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Kuwait; Logistic Models; Male; Motor Activity; Reference Values; Risk Factors; Sex Factors; Socioeconomic Factors; Vitamin B 12; Vitamin B Complex; Young Adult | 2012 |
Methyl deficient diet aggravates experimental colitis in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Choline Deficiency; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Dextran Sulfate; Diet; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Homocysteine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Tissue Inhibitor of Metalloproteinase-3; Tumor Necrosis Factor-alpha; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Body Composition; Body Mass Index; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Japan; Linear Models; Male; Middle Aged; Nutritional Status; Young Adult | 2011 |
Evaluation of the roles of serum vitamin B(12), folate and homocysteine levels in laryngeal squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Case-Control Studies; Demography; Folic Acid; Homocysteine; Humans; Laryngeal Neoplasms; Middle Aged; Vitamin B 12 | 2010 |
Serum homocysteine as a biomarker of vitiligo vulgaris severity: a pilot study.
Topics: Biomarkers; Folic Acid; Homocysteine; Pilot Projects; Vitamin B 12; Vitiligo | 2011 |
No relation between folate and homocysteine levels and depression in early pregnant women.
Topics: Adult; Cross-Sectional Studies; Depression; Diet; Female; Folic Acid; Homocysteine; Humans; Japan; Odds Ratio; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Psychiatric Status Rating Scales; Vitamin B 12; Vitamin B 6 | 2010 |
Serum folate and homocysteine levels are associated with colon tumorigenesis in end-stage renal disease patients.
Topics: Adult; Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Linear Models; Male; Middle Aged; Renal Dialysis; Risk Factors; Serum | 2011 |
Dietary oligosaccharides increase colonic weight and the amount but not concentration of bacterially synthesized folate in the colon of piglets.
Topics: Animals; Bacterial Load; Bifidobacterium; Colon; Erythrocytes; Folic Acid; Folic Acid Deficiency; Gastrointestinal Contents; Homocysteine; Inulin; Kidney; Lactobacillales; Liver; Male; Nutritional Status; Oligosaccharides; Organ Size; Prebiotics; Random Allocation; Sus scrofa | 2011 |
Folate and cobalamin status in relation to diet in healthy 2-y-old children.
Topics: Child, Preschool; Dairy Products; Diet; Diet Records; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Acid; Multivariate Analysis; Norway; Nutrition Policy; Nutritional Status; Transcobalamins; Vitamin B 12; Vitamin B Complex | 2011 |
Polyneuropathy and dementia in old age: common inflammatory and vascular parameters.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Cohort Studies; Dementia; Female; Folic Acid; Geriatrics; Homocysteine; Humans; Inflammation; Male; Mental Status Schedule; Neopterin; Neural Conduction; Polyneuropathies; Sural Nerve; Vascular Diseases; Vitamin B 12 | 2011 |
Impaired endothelial function in preadolescent children with type 1 diabetes.
Topics: Blood Glucose; Brachial Artery; C-Reactive Protein; Carotid Arteries; Child; Diabetes Mellitus, Type 1; Endothelium, Vascular; Fasting; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Male; Tunica Intima; Tunica Media; Ultrasonography | 2011 |
Total blood mercury, plasma homocysteine, methylmalonic acid and folate in US children aged 3-5 years, NHANES 1999-2004.
Topics: Child, Preschool; Cross-Sectional Studies; Environmental Exposure; Environmental Pollutants; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Mercury; Methylmalonic Acid; Nutrition Surveys; United States | 2011 |
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population.
Topics: Aged; Alcohol Drinking; Alleles; Boston; Cross-Sectional Studies; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Life Style; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Motor Activity; Polymorphism, Single Nucleotide; Proton-Coupled Folate Transporter; Puerto Rico; Sex Factors; Smoking; Vitamin B 12 | 2011 |
Hyperhomocysteinemia decreases bone blood flow.
Topics: Animals; Biomarkers; Biomechanical Phenomena; Blood Pressure; Bone Density; Bone Remodeling; Disease Models, Animal; Folic Acid; Homocysteine; Hyperhomocysteinemia; Laser-Doppler Flowmetry; Male; Osteoporosis; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tibia; Time Factors; Up-Regulation; Vitamin B 12 | 2011 |
Folate and vitamin B12 improved alcohol-induced hyperhomocysteinemia in rats.
Topics: Animals; Cytochromes; Folic Acid; Homocysteine; Hyperhomocysteinemia; Liver; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Matrix Metalloproteinase 2; Rats; Rats, Wistar; Vitamin B 12; Vitamin B Complex | 2011 |
Physiologic changes in homocysteine metabolism in pregnancy: a longitudinal study in Spain.
Topics: Adult; Diabetes, Gestational; Dietary Supplements; Female; Fetal Growth Retardation; Folic Acid; Genotype; Homocysteine; Humans; Hypertension, Pregnancy-Induced; Longitudinal Studies; Methylenetetrahydrofolate Reductase (NADPH2); Nutrition Policy; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Prevalence; Spain; Vitamin B 12 | 2011 |
Do the effects of APOE-ε4 on cognitive function and decline depend upon vitamin status? MacArthur Studies of Successful Aging.
Topics: Aged; Aging; Apolipoprotein E4; Cognition; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Longitudinal Studies; Male; Nutrigenomics; Nutritional Status; United States; Vitamin B Complex | 2011 |
Hyperhomocysteinaemia, vascular related pregnancy complications and the response to vitamin supplementation in pregnant women of Pakistan.
Topics: Abruptio Placentae; Case-Control Studies; Cohort Studies; Eclampsia; Female; Folic Acid; Gestational Age; Homocysteine; Hospitals, Teaching; Humans; Hyperhomocysteinemia; Pakistan; Pregnancy; Pregnancy Outcome; Vitamin B 6; Vitamin B Complex | 2010 |
A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Topics: Adult; Aged; Alcohol Drinking; Body Mass Index; Case-Control Studies; Cotinine; Diabetes Complications; DNA-Binding Proteins; Europe; Female; Flavin Mononucleotide; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Logistic Models; Male; Methionine; Middle Aged; Odds Ratio; Pancreatic Neoplasms; Prospective Studies; Pyridoxal Phosphate; Riboflavin; Risk Factors; Sex Factors; Smoking; Transcription Factors; Vitamin B 12; Vitamin B Complex | 2011 |
Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats.
Topics: Animals; Diet; DNA Methylation; Docosahexaenoic Acids; Fatty Acids; Feeding Behavior; Female; Folic Acid; Homocysteine; Placenta; Pregnancy; Rats; Reproduction; Vitamin B 12 | 2011 |
Serum folate is significantly correlated with plasma cysteine concentrations in healthy industry workers.
Topics: Adult; Aged; Aging; Cardiovascular Diseases; Cysteine; Extraction and Processing Industry; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Neoplasms; Norway; Risk Factors; Triglycerides; Young Adult | 2011 |
What is the meaning of homocysteine in patients on dialysis?
Topics: Adult; Aged; Biomarkers; Brazil; C-Reactive Protein; Creatine Kinase; Creatinine; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Interleukin-6; Kidney Failure, Chronic; Linear Models; Lipids; Male; Malnutrition; Middle Aged; Peritoneal Dialysis; Prevalence; Renal Dialysis; Risk Factors; Tumor Necrosis Factor-alpha; Vitamin B 12 | 2011 |
[Significance of plasmic homocysteine, folate and Vitamin B(12) in ulcerative colitis].
Topics: Adolescent; Adult; Aged; Case-Control Studies; Colitis, Ulcerative; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Young Adult | 2011 |
Associations among objectively measured physical activity, fasting plasma homocysteine concentration, and MTHFR C677T genotype.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Cross-Sectional Studies; Diet; Fasting; Feeding Behavior; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Motor Activity; Polymorphism, Genetic; Surveys and Questionnaires | 2011 |
Homocysteine mediated decrease in bone blood flow and remodeling: role of folic acid.
Topics: Animals; Bone Density; Bone Remodeling; Folic Acid; Homocysteine; Hyperhomocysteinemia; Matrix Metalloproteinase 9; Mice; Nitric Oxide; Osteoporosis; Oxidative Stress; Regional Blood Flow; Tibia; Tibial Arteries | 2011 |
Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Dementia; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Retrospective Studies; Statistics, Nonparametric; Tunisia | 2011 |
Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study.
Topics: Adult; Aged; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylmalonic Acid; Middle Aged; Thrombosis; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B₁₂ status in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Discriminant Analysis; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Kidney Function Tests; Linear Models; Male; Methylmalonic Acid; Middle Aged; Predictive Value of Tests; Reference Values; ROC Curve; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2011 |
The MMACHC proteome: hallmarks of functional cobalamin deficiency in humans.
Topics: Amino Acid Metabolism, Inborn Errors; Carrier Proteins; Cell Line; Cells, Cultured; Fibroblasts; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Intracellular Space; Metabolic Networks and Pathways; Methylmalonic Acid; Mutation; Oxidoreductases; Phenotype; Proteome; Vimentin; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2011 |
Dietary, lifestyle and pharmacogenetic factors associated with arteriole endothelial-dependent vasodilatation in schizophrenia patients treated with atypical antipsychotics (AAPs).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arterioles; Catechol O-Methyltransferase; Cross-Sectional Studies; Endothelium-Dependent Relaxing Factors; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Manometry; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Regression Analysis; Schizophrenia; Schizophrenic Psychology; Young Adult | 2011 |
Vitamin B12 and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate.
Topics: Adult; China; Chromates; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2011 |
Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain.
Topics: Animals; Brain; Female; Folic Acid; Frontal Lobe; Homocysteine; Homocystine; Hyperhomocysteinemia; Methionine; Methylation; Neurofilament Proteins; Phosphoproteins; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; tau Proteins | 2011 |
Vitamin supplementation reduces the level of homocysteine in the urine of autistic children.
Topics: Autistic Disorder; Child; Child, Preschool; Creatinine; Dietary Supplements; Female; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Male; Vitamin B 12; Vitamin B 6 | 2011 |
A longitudinal study of maternal folate and vitamin B12 status in pregnancy and postpartum, with the same infant markers at 6 months of age.
Topics: Adult; Australia; Biomarkers; Breast Feeding; Cross-Sectional Studies; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Infant; Longitudinal Studies; Luminescent Measurements; Postpartum Period; Pregnancy; Pregnancy Complications; Socioeconomic Factors; Vitamin B 12; Vitamin B Complex; Young Adult | 2012 |
Lipid profiles and oxidative stress parameters in male and female hemodialysis patients.
Topics: Aged; Atherosclerosis; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Lipids; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Renal Dialysis; Risk Assessment; Risk Factors; Triglycerides; Vitamin B 12 | 2011 |
Plasma homocysteine and cognitive decline in older hypertensive subjects.
Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Cognition; Cognition Disorders; Executive Function; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hypertension; Male; Neuropsychological Tests; Risk Factors; Vitamin B 12 | 2011 |
Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aryldialkylphosphatase; Case-Control Studies; Coronary Artery Disease; Cystathionine beta-Synthase; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genotype; Homocysteine; Humans; INDEL Mutation; Logistic Models; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Sequence Analysis, DNA | 2011 |
Maternal folate, vitamin B12 and homocysteine levels in pregnancies affected by congenital malformations other than neural tube defects.
Topics: Congenital Abnormalities; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Risk Factors; Vitamin B 12 | 2011 |
The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Boston; Cross-Sectional Studies; Depression; Female; Folate Receptor 1; Folic Acid; Folic Acid Deficiency; gamma-Glutamyl Hydrolase; Gene Frequency; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Linear Models; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Proton-Coupled Folate Transporter; Psychiatric Status Rating Scales; Pteroylpolyglutamic Acids; Puerto Rico; Pyridoxal Phosphate; Reduced Folate Carrier Protein; Vitamin B 12 | 2011 |
Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Austria; Edible Grain; Environment; Female; Ferredoxin-NADP Reductase; Folic Acid; Folic Acid Antagonists; Food, Fortified; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Sex Characteristics; Smoking; United States; Vitamin B 12 | 2011 |
Plasma homocysteine levels, methylene tetrahydrofolate reductase polymorphisms, and the risk of thromboembolism in children.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Prevalence; Reference Values; Risk Factors; Thromboembolism; Vitamin B Complex; Young Adult | 2011 |
Homocysteinemia and B vitamin status among adult patients with inflammatory bowel disease: a one-year prospective follow-up study.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Nutritional Status; Prospective Studies; Severity of Illness Index; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamin B Complex | 2012 |
The basis of differential responses to folic acid supplementation.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Models, Genetic; Nutrigenomics; Polymorphism, Single Nucleotide; Twins, Dizygotic; Twins, Monozygotic; Vitamin B 12 | 2011 |
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1.
Topics: Acetylation; Animals; Apoptosis; Cardiomyopathies; Cell Respiration; Energy Metabolism; ERRalpha Estrogen-Related Receptor; Fatty Acids; Female; Folic Acid; Homocysteine; Methylation; Mitochondria, Heart; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Positron-Emission Tomography; PPAR alpha; Protein-Arginine N-Methyltransferases; Proteomics; Rats; Rats, Wistar; Receptors, Estrogen; RNA-Binding Proteins; Sirtuin 1; Stress, Physiological; Transcription Factors; Vitamin B Deficiency | 2011 |
Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?
Topics: Adult; Cross-Sectional Studies; Female; Ferritins; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2011 |
Trends in folate status in the Taiwanese population aged 19 years and older from the Nutrition and Health Survey in Taiwan 1993-1996 to 2005-2008.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Female; Folic Acid; Folic Acid Deficiency; Fruit; Health Surveys; Homocysteine; Humans; Male; Middle Aged; Nutrition Surveys; Nutritional Status; Prevalence; Sex Distribution; Taiwan; Vegetables; Young Adult | 2011 |
TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic stroke patients.
Topics: China; Ethnicity; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; India; Malaysia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymorphism, Genetic; Stroke; Vitamin B 12 | 2011 |
Polymorphism C1420T of Serine hydroxymethyltransferase gene on maternal risk for Down syndrome.
Topics: DNA Primers; Down Syndrome; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Inheritance Patterns; Logistic Models; Methylmalonic Acid; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors | 2012 |
Anticonvulsive effect of folic acid in homocysteine thiolactone-induced seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Folic Acid; Homocysteine; Male; Rats; Rats, Wistar; Seizures | 2011 |
Elevated maternal serum folate in the third trimester and reduced fetal growth: a longitudinal study.
Topics: Adult; Biomarkers; Birth Weight; Body Height; Dietary Supplements; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Infant; Longitudinal Studies; Nutritional Status; Pregnancy; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Pyridoxal; Vitamin B 12; Vitamin B Complex; Weight Gain | 2011 |
Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
Topics: Adult; Asian People; Cardiovascular Diseases; Cross-Sectional Studies; Diet; Diet Records; Diet Surveys; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Linear Models; Malaysia; Male; Middle Aged; Neural Tube Defects; Nutritional Status; Sex Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Young Adult | 2011 |
Brain biochemical correlates of the plasma homocysteine level: a proton magnetic resonance spectroscopy study in the elderly subjects.
Topics: Aged; Aspartic Acid; Basal Ganglia; Brain; Choline; Cobamides; Creatine; Female; Folic Acid; Frontal Lobe; Hippocampus; Homocysteine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Sex Characteristics | 2011 |
Homocysteine and cognitive function in very elderly nondemented subjects.
Topics: Aged, 80 and over; Apolipoprotein E4; Cognition; Executive Function; Female; Folic Acid; Homocysteine; Humans; Male; Neuropsychological Tests; Vitamin B 12 | 2011 |
Homocysteine in Alzheimer's disease: role of dietary folate, vitamin B6 and B12.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Diet; Diet Records; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12; Vitamin B 6 | 2011 |
Persistent homocysteine metabolism abnormality accelerates cardiovascular disease in hemodialyzed patients--the Nishinomiya Study.
Topics: Body Mass Index; Cardiovascular Diseases; Creatinine; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Middle Aged; Prospective Studies; Renal Dialysis; Vitamin B 12 | 2012 |
Efficacy of flour fortification with folic acid in women of childbearing age in Iran.
Topics: Adolescent; Adult; Bread; Cross-Sectional Studies; Female; Flour; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Iran; Longitudinal Studies; Middle Aged; Neural Tube Defects; Nutritional Status; Socioeconomic Factors; Vitamin B 12; Young Adult | 2011 |
Folate and cardiovascular disease: one size does not fit all.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Stroke; Vitamin B Complex | 2011 |
Medication adherence assessment in a clinical trial with centralized follow-up and direct-to-patient drug shipments.
Topics: Folic Acid; Follow-Up Studies; Homocysteine; Humans; Medication Adherence; Medication Systems; Randomized Controlled Trials as Topic; Regression Analysis; Self Report; Statistics, Nonparametric; Vitamins | 2013 |
Dietary methyl-consuming compounds and metabolic syndrome.
Topics: Animals; Arsenicals; Catecholamines; Diet; Folic Acid; Homocysteine; Humans; Hypolipidemic Agents; Insulin Resistance; Metabolic Syndrome; Methionine; Niacin; Reactive Oxygen Species | 2011 |
Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people.
Topics: Aged; Aged, 80 and over; Arginine; Biological Availability; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; Statistics as Topic; Vasodilation; Vitamin B 12; Vitamin B 6 | 2011 |
Homocysteine homeostasis in the rat is maintained by compensatory changes in cystathionine β-synthase, betaine-homocysteine methyltransferase, and phosphatidylethanolamine N-methyltransferase gene transcription occurring in response to maternal protein an
Topics: Animal Nutritional Physiological Phenomena; Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Diet; Diet, High-Fat; Diet, Protein-Restricted; Dietary Fats; Dietary Proteins; Dietary Supplements; Down-Regulation; Female; Folic Acid; Gene Expression; Homeostasis; Homocysteine; Liver; Male; Methionine; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Pregnancy; Prenatal Nutritional Physiological Phenomena; Rats, Wistar; Vitamin B Complex; Weaning | 2011 |
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist.
Topics: Animals; Cognition Disorders; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Folic Acid; Glutamic Acid; Homocysteine; Humans; Injections, Spinal; Male; Memory Disorders; Methotrexate; Rats; Rats, Long-Evans; Recognition, Psychology | 2011 |
Folate and vitamin B12 in idiopathic male infertility.
Topics: Adult; Case-Control Studies; Folic Acid; Homocysteine; Humans; Infertility, Male; Male; Middle Aged; Sweden; Vitamin B 12 | 2011 |
Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population.
Topics: Adult; Alleles; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Polymorphism, Single Nucleotide; Prevalence; Replication Protein C; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamin B Deficiency | 2012 |
Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Analysis of Variance; Australia; Brain; Cognitive Dysfunction; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Vitamin B 12 | 2011 |
Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey.
Topics: Adolescent; Adult; Aged; Biomarkers; Canada; Child; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Health Surveys; Homocysteine; Humans; Legislation, Food; Male; Middle Aged; Nutritional Status; Obesity; Prevalence; Severity of Illness Index; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2011 |
Plasma choline concentration varies with different dietary levels of vitamins B6, B12 and folic acid in rats maintained on choline-adequate diets.
Topics: Animals; Biological Availability; Choline; Diet; Dietary Supplements; Folic Acid; Homocysteine; Male; Methylation; Rats; Rats, Sprague-Dawley; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2012 |
Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status.
Topics: Absorptiometry, Photon; Age Factors; Aged; Alcohol Drinking; Bone Density; Croatia; Erythrocytes; Estrogen Replacement Therapy; Female; Folic Acid; Homocysteine; Humans; Life Style; Middle Aged; Postmenopause; Vitamin B 12 | 2012 |
Reference interval and determinants of the serum homocysteine level in a Korean population.
Topics: Adult; Aged; Analysis of Variance; Asian People; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Life Style; Male; Middle Aged; Nutritional Status; Reference Values; Republic of Korea; Statistics, Nonparametric | 2011 |
Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency.
Topics: Disulfides; DNA-Binding Proteins; Folate Receptor 1; Folic Acid; Folic Acid Deficiency; HeLa Cells; Heterogeneous-Nuclear Ribonucleoproteins; Homocysteine; Humans; Protein Binding; Protein Structure, Tertiary; RNA-Binding Proteins; RNA, Messenger; Up-Regulation | 2011 |
A folate receptor alpha double-mutated haplotype 1816delC-1841A is distributed throughout Eurasia and associated with lower erythrocyte folate levels.
Topics: Adult; Alleles; Asia; Base Pairing; Erythrocytes; Europe; Female; Folate Receptor 1; Folic Acid; Haplotypes; Homocysteine; Humans; Male; Mutation; Polymerase Chain Reaction; Prevalence; Vitamin B 12 | 2012 |
Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative colitis in Chinese Han population in Central China [corrected].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Amino Acid Substitution; Asian People; China; Colitis, Ulcerative; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Vitamin B 12 | 2012 |
Serum homocysteine and folate but not vitamin B12 are predictors of CHD mortality in older adults.
Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Coronary Disease; Down-Regulation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; New South Wales; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Up-Regulation; Vitamin B 12 | 2012 |
[Serum levels of antioxidants and vitamins related to the homocystein's metabolism during postmenopause].
Topics: Abdominal Fat; Antioxidants; Body Mass Index; Cross-Sectional Studies; Estrogens; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Hormone Replacement Therapy; Humans; Hyperhomocysteinemia; Middle Aged; Motor Activity; Overweight; Postmenopause; Progesterone; Risk; Urban Population; Vitamin B 12; Vitamin B 6; Waist-Hip Ratio | 2005 |
[Hyperhomocysteinemia and schizophrenia: case control study].
Topics: Adult; Case-Control Studies; Chronic Disease; Comorbidity; Cross-Sectional Studies; Female; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Reference Values; Schizophrenia; Schizophrenic Psychology; Statistics as Topic; Vitamin B 12 | 2011 |
Total blood mercury and serum measles antibodies in US children, NHANES 2003-2004.
Topics: Antibodies, Viral; Child; Cross-Sectional Studies; Environmental Exposure; Environmental Pollutants; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Measles; Measles virus; Mercury; Methylmalonic Acid; Nutrition Surveys; United States | 2011 |
Folate, vitamin B12, vitamin B6 and homocysteine: impact on pregnancy outcome.
Topics: Adult; Biomarkers; Dietary Supplements; DNA Damage; Erythrocyte Count; Female; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Logistic Models; Multivariate Analysis; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prospective Studies; South Australia; Vitamin B 12; Vitamin B 6 | 2013 |
Folic acid supplements modify the adverse effects of maternal smoking on fetal growth and neonatal complications.
Topics: Adult; Birth Weight; Dietary Supplements; Female; Fetal Development; Fetal Weight; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature, Diseases; Netherlands; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Premature Birth; Prospective Studies; Smoking; Young Adult | 2011 |
Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls.
Topics: Age of Onset; Aged; Alleles; Alzheimer Disease; Biomarkers; Case-Control Studies; Female; Folic Acid; Genotype; Health; Homocysteine; Humans; Male; Polymorphism, Genetic; Vitamin B 12 | 2012 |
Protective effect of folic acid on cyclosporine-induced bone loss in rats.
Topics: Animal Feed; Animals; Bone Density; Cyclosporine; Folic Acid; Homocysteine; Immunosuppressive Agents; Male; Models, Biological; Models, Statistical; Rats; Rats, Sprague-Dawley | 2012 |
Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.
Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Chick Embryo; Chromatography, High Pressure Liquid; Folic Acid; Foot Deformities; Glutathione; Hindlimb; Histone Deacetylases; Homocysteine; Hydrogen Peroxide; Joints; Muscle, Skeletal; Neovascularization, Physiologic; Superoxide Dismutase; Teratogens; Tissue Embedding; Valproic Acid; Vitamins | 2012 |
Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia.
Topics: Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Diabetic Retinopathy; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Prognosis; Risk Factors; Vitamin B 12 Deficiency; Vitamin B Complex | 2011 |
Triplex tetra-primer ARMS-PCR method for the simultaneous detection of MTHFR c.677C>T and c.1298A>C, and MTRR c.66A>G polymorphisms of the folate-homocysteine metabolic pathway.
Topics: Betaine; DNA Primers; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Homocysteine; Humans; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide | 2012 |
Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study.
Topics: Aged; Cognition Disorders; Executive Function; Female; Folic Acid; Homocysteine; Humans; Male; Memory, Episodic; Prospective Studies; Psychomotor Performance; Reaction Time; Speech; Transcobalamins | 2012 |
The Ottawa and Kingston (OaK) Birth Cohort: development and achievements.
Topics: Canada; Cohort Studies; Dietary Supplements; Female; Fetal Blood; Fetal Growth Retardation; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Newborn; Maternal Nutritional Physiological Phenomena; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prenatal Care; Prospective Studies; Thrombophilia; Vitamins | 2011 |
Modulator effects of the methylenetetrahydrofolate reductase C677T polymorphism on response to vitamin B12 therapy and homocysteine metabolism.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Vitamin B 12; Vitamin B 12 Deficiency | 2012 |
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Artery, Common; Cross-Sectional Studies; Epilepsy; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Phenytoin; Risk Factors; Time Factors; Uric Acid; Valproic Acid; Young Adult | 2012 |
The effects of homocysteine and folic acid on angiogenesis and VEGF expression during chicken vascular development.
Topics: Animals; Blood Vessels; Chick Embryo; Down-Regulation; Extraembryonic Membranes; Folic Acid; Gene Expression Regulation, Developmental; Homocysteine; Image Processing, Computer-Assisted; Neovascularization, Physiologic; Real-Time Polymerase Chain Reaction; RNA, Messenger; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Effect of regular physical activity on non-lipid (novel) cardiovascular risk factors.
Topics: Adult; Body Mass Index; Cardiovascular Diseases; Cytokines; Exercise; Folic Acid; Homocysteine; Humans; Iran; Military Personnel; Risk Factors; Sedentary Behavior; Testosterone; Vitamin D; Young Adult | 2011 |
Vitamin B₁₂ deficiency & levels of metabolites in an apparently normal urban south Indian elderly population.
Topics: Aged; Diet, Vegetarian; Erythrocytes; Female; Folic Acid; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; India; Male; Methylmalonic Acid; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.
Topics: Adult; Aged; Aged, 80 and over; Alu Elements; Aminohydrolases; Cardiovascular Diseases; DNA Methylation; Folic Acid; Formate-Tetrahydrofolate Ligase; Gene Regulatory Networks; Genetic Association Studies; Genetic Variation; Genotype; Homocysteine; Humans; Long Interspersed Nucleotide Elements; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multienzyme Complexes; Phenotype; Polymorphism, Single Nucleotide; Sarcosine Dehydrogenase; Vitamin B 6 | 2011 |
Folate and vitamin B12-related genes and risk for omphalocele.
Topics: Folic Acid; Genetic Predisposition to Disease; Genotype; Hernia, Umbilical; Homocysteine; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Pilot Projects; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Risk; Vitamin B 12 | 2012 |
Comments on "Vitamin supplementation reduces the level of homocysteine in the urine of autistic children".
Topics: Autistic Disorder; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12; Vitamin B 6 | 2011 |
Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Choline; Decitabine; Diet; Disease Progression; DNA Methylation; Folic Acid; Homocysteine; Humans; Male; Methionine; Mice; Mice, Nude; Prostatic Neoplasms; Tumor Cells, Cultured; Vitamin B 6 | 2012 |
A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis.
Topics: Alleles; Case-Control Studies; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Hispanic or Latino; Homocysteine; Humans; Infant, Newborn; Metabolic Networks and Pathways; Models, Genetic; Mutation; Purines; Risk Factors; Spinal Dysraphism; White People | 2011 |
Fortification of flours with folic acid reduces homocysteine levels in Brazilian women.
Topics: Adult; Biomarkers; Brazil; Cardiovascular Diseases; Cross-Sectional Studies; Diet; Dietary Fiber; Edible Grain; Female; Flour; Folic Acid; Food, Fortified; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Middle Aged; Nutrition Assessment; Nutrition Policy; Obesity; Triticum; Zea mays | 2011 |
[Protective effects and its mechanism on neural cells after folic acid intervention in preeclampsia rat model].
Topics: Animals; Apoptosis; Disease Models, Animal; Female; Folic Acid; Homocysteine; Male; Neurons; Neuroprotective Agents; NF-kappa B; Pre-Eclampsia; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Sodium Glutamate | 2011 |
Suppression of homocysteine levels by vitamin B12 and folates: age and gender dependency in the Jackson Heart Study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Black or African American; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Middle Aged; Mississippi; Sex Factors; Vitamin B 12; Young Adult | 2012 |
Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in patients with vitiligo.
Topics: Adult; Biomarkers; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Logistic Models; Male; Middle Aged; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Vitiligo; Young Adult | 2012 |
Hyperhomocysteinemia among Omani autistic children: a case-control study.
Topics: Autistic Disorder; Biomarkers; Case-Control Studies; Child, Preschool; Fasting; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Reference Values; Vitamin B 12 | 2011 |
Holotranscobalamin: not ready for prime time.
Topics: Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2012 |
Methylenetetrahydrofolate reductase gene 677CT polymorphism and isolated congenital heart disease in a Mexican population.
Topics: Adolescent; Adult; Alleles; Child; Child, Preschool; DNA; Female; Folic Acid; Gene Frequency; Heart Defects, Congenital; Homocysteine; Humans; Infant; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Polymerase Chain Reaction; Polymorphism, Genetic; Pregnancy; Prenatal Care; Young Adult | 2012 |
Folate, vitamin B12 and homocysteine status in an Italian blood donor population.
Topics: Adolescent; Adult; Aged; Blood Donors; Chromatography, High Pressure Liquid; Feeding Behavior; Female; Folic Acid; Fruit; Homocysteine; Humans; Italy; Logistic Models; Male; Middle Aged; Motor Activity; Specimen Handling; Surveys and Questionnaires; Vegetables; Vitamin B 12; Young Adult | 2013 |
Association of methylentetraydrofolate reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study.
Topics: Adult; Case-Control Studies; Ethnicity; Female; Folic Acid; Genotype; Homocysteine; Humans; Malaysia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Psoriasis; Vitamin B 12 | 2012 |
Therapy of hyperhomocysteinemia in hemodialysis patients: effects of folates and N-acetylcysteine.
Topics: Acetylcysteine; Aged; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 2012 |
Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B12 and homocysteine profile.
Topics: Adult; Anencephaly; Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Polymorphism, Genetic; Pregnancy; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B Complex | 2012 |
Serum homocysteine level and its association with folic acid and vitamin B12 in the third trimester of pregnancies complicated with intrauterine growth restriction.
Topics: Adult; Female; Fetal Growth Retardation; Fetal Weight; Folic Acid; Homocysteine; Humans; Pregnancy; Pregnancy Trimester, Third; Vitamin B 12; Young Adult | 2011 |
Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Disease Models, Animal; DNA Methylation; Folic Acid; Gastric Mucosa; Gastrins; Gastritis; Gene Expression Profiling; Gene Expression Regulation; Helicobacter felis; Helicobacter Infections; Homocysteine; Immunohistochemistry; Lymphocytes; Male; Mice; Mice, Transgenic; Myofibroblasts; Stomach; Stomach Neoplasms; Stromal Cells; Up-Regulation | 2012 |
Hepatitis C virus co-infection and sexual risk behaviour are associated with a high homocysteine serum level in HIV-infected patients.
Topics: Adult; Cardiovascular Diseases; Coinfection; Cross-Sectional Studies; Female; Folic Acid; Hepacivirus; Hepatitis C; HIV; HIV Infections; Homocysteine; Humans; Male; Risk Factors; Risk-Taking; Sexual Behavior; Vitamin B 12 | 2012 |
Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism.
Topics: Adult; Astronauts; Carbon Dioxide; Citrates; Cystathionine; Female; Folic Acid; Homocysteine; Humans; Male; Metabolic Networks and Pathways; Methylmalonic Acid; Middle Aged; Models, Biological; Refraction, Ocular; Space Flight; Vision Disorders; Vitamin B 12 | 2012 |
Methylation capacity in children with severe cerebral palsy.
Topics: Betaine; Biomarkers; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Choline; Cystathionine; DNA Methylation; Erythrocyte Indices; Erythrocyte Membrane; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Queensland; Severity of Illness Index; Uric Acid | 2012 |
Solute Carrier Family 19, member 1 (SLC19A1) polymorphisms (-43T>C, 80G>A, and 696C>T), and haplotypes in idiopathic recurrent spontaneous abortion in a Korean population.
Topics: Abortion, Habitual; Adult; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Homocysteine; Humans; Korea; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Reduced Folate Carrier Protein; Risk Factors | 2012 |
Elevated plasma homocysteine in association with decreased vitamin B(12), folate, serotonin, lipids and lipoproteins in depressed patients.
Topics: Adult; Cholesterol; Depressive Disorder; Female; Folic Acid; Homocysteine; Humans; Lipids; Lipoproteins; Male; Middle Aged; Risk Factors; Serotonin; Sex Distribution; Vitamin B 12; Young Adult | 2012 |
Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice.
Topics: Animals; Circadian Rhythm; Darkness; DNA; DNA Methylation; DNA Replication; Fatty Acids; Folic Acid; Folic Acid Deficiency; Gene Expression; Homocysteine; Hyperhomocysteinemia; Light; Lipid Metabolism; Liver; Male; Melatonin; Mice; Nuclear Proteins; Phosphatidate Phosphatase; Vitamin B Complex | 2012 |
The Mediterranean diet and fetal size parameters: the Generation R Study.
Topics: Adult; Birth Weight; C-Reactive Protein; Diet, Mediterranean; Energy Intake; Feeding Behavior; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Homocysteine; Humans; Logistic Models; Netherlands; Organ Size; Patient Compliance; Placenta; Pregnancy; Prenatal Nutritional Physiological Phenomena; Prospective Studies; Qualitative Research; Surveys and Questionnaires; Vitamin B 12; White People | 2012 |
Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo.
Topics: Animals; Base Sequence; Capsid Proteins; Catalase; Cell Culture Techniques; Cell Proliferation; Cell Transformation, Viral; Cells, Cultured; DNA-Binding Proteins; Female; Folic Acid; Folic Acid Deficiency; Genes, Reporter; Heterogeneous-Nuclear Ribonucleoproteins; Homocysteine; Host-Pathogen Interactions; Human papillomavirus 16; Humans; Keratinocytes; Mice; Mice, Nude; Molecular Sequence Data; Neoplasms, Experimental; Oncogene Proteins, Viral; Papillomavirus Infections; Protein Binding; Proteolysis; RNA-Binding Proteins; RNA, Messenger; RNA, Viral; Sulfhydryl Compounds; Tumor Burden; Virus Integration | 2012 |
Coenzyme Q10, hyperhomocysteinemia and MTHFR C677T polymorphism in levodopa-treated Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Polymorphism, Genetic; Ubiquinone; Vitamin B 12 | 2012 |
Pregnancy and a rare MTHFR haplotype.
Topics: Adult; Female; Folic Acid; Haplotypes; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy; Pregnancy Complications | 2012 |
Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics.
Topics: Adult; Age Factors; Antipsychotic Agents; Bipolar Disorder; Catechol O-Methyltransferase; Cross-Sectional Studies; Female; Folic Acid; Genetic Variation; Homocysteine; Humans; Life Style; Male; Metabolic Syndrome; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Risk Factors; Schizophrenia; Smoking | 2012 |
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Embryo Loss; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genes, Lethal; Heterozygote; Homocysteine; Hypoxanthine; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Mutant Strains; Multienzyme Complexes; Mutagenesis, Insertional; Neural Tube Defects; Pregnancy | 2012 |
[Effects of folic acid on cerebrovascular and cancer risks].
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Neoplasms; Vitamin B Complex | 2012 |
Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Air Pollutants, Occupational; Air Pollution, Indoor; China; Chromates; Comet Assay; Deoxyguanosine; DNA Breaks; DNA Damage; DNA Methylation; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Homocysteine; Humans; Indicators and Reagents; Male; Malondialdehyde; Occupational Exposure; Oxidation-Reduction; Superoxide Dismutase | 2012 |
Marked gender difference in plasma total homocysteine concentrations in indian adults with low vitamin B₁₂.
Topics: Adult; Age Factors; Body Composition; Erythrocytes; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2011 |
Role of folic acid depletion on homocysteine serum level in children and adolescents with epilepsy and different MTHFR C677T genotypes.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vitamin B 12 | 2012 |
Effectiveness of B vitamins on the control of hypertension and stroke events of SHRSP rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Antioxidants; Ataxia; Blood Pressure; Dietary Supplements; Folic Acid; Homocysteine; Hypertension; Ischemia; Male; Malondialdehyde; Oxidative Stress; Postural Balance; Pyridoxine; Rats; Rats, Inbred SHR; Riboflavin; Seizures; Stroke; Treatment Outcome; Vitamin B Complex | 2010 |
Nɛ-homocysteinyl-lysine isopeptide is associated with progression of peripheral artery disease in patients treated with folic acid.
Topics: Aged; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Metabolism; Middle Aged; Oxidative Stress; Peptides; Peripheral Arterial Disease; Proteins; Vitamin B Complex | 2012 |
Effects of methyl-deficient diets on methionine and homocysteine metabolism in the pregnant rat.
Topics: Animals; Choline; Cysteine; Diet; Female; Fetus; Folic Acid; Homocysteine; Kinetics; Litter Size; Liver; Methionine; Methylation; Pancreas; Phosphorylcholine; Placenta; Pregnancy; Rats; Triglycerides; Weight Gain | 2012 |
Homocysteine and hydroxyproline levels in patients with primary open-angle glaucoma.
Topics: Aged; Aqueous Humor; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Folic Acid; Glaucoma, Open-Angle; Homocysteine; Humans; Hydroxyproline; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Spectrum Analysis; Vitamin B 12; Vitamin B 6 | 2012 |
Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Cystathionine beta-Synthase; Female; Folic Acid; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Pakistan; Polymorphism, Single Nucleotide; Pyridoxal Phosphate; Risk Factors; Sex Factors; Vitamin B 12; Young Adult | 2012 |
Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study.
Topics: Adult; Birth Weight; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Infant, Small for Gestational Age; Male; Netherlands; Organ Size; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Risk Factors; Vitamin B 12; Young Adult | 2012 |
Folate intake and incidence of hypertension among American young adults: a 20-y follow-up study.
Topics: Adolescent; Adult; Black or African American; Blood Pressure; Diet; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hypertension; Incidence; Interviews as Topic; Longitudinal Studies; Male; Proportional Hazards Models; Prospective Studies; Regression Analysis; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; White People; Young Adult | 2012 |
Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese.
Topics: Adolescent; Amplified Fragment Length Polymorphism Analysis; Child; Diet; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Health Surveys; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Japan; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Vascular Diseases; Vitamin B 12; Vitamin B 6 | 2012 |
A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.
Topics: Case-Control Studies; Drug Synergism; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; India; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Nutrigenomics; Odds Ratio; Polymorphism, Genetic; Risk Assessment; Uterine Cervical Neoplasms; Vitamin B 12; Vitamin B Complex | 2012 |
Relationships among biomarkers of one-carbon metabolism.
Topics: Adult; Aging; Biomarkers; Creatinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; One-Carbon Group Transferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Characteristics; Vitamin B 12; Young Adult | 2012 |
Relationship between vitamin B12, folate and homocysteine levels and H. pylori infection in patients with functional dyspepsia: a cross-section study.
Topics: Adult; Aged; Cross-Sectional Studies; Dyspepsia; Female; Folic Acid; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2012 |
Increased homocysteinemia is associated with beneficial effects on body weight after long-term high-protein, low-fat diet in rats.
Topics: Adipose Tissue; Animals; Diet, Fat-Restricted; Dietary Proteins; Energy Intake; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Obesity; Rats; Rats, Long-Evans; Weight Gain | 2012 |
[Correlation of homocysteine in plasma with NOS and endogenous CO in the penile corpus cavernosum of type 2 diabetic rats].
Topics: Animals; Carbon Monoxide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Folic Acid; Homocysteine; Insulin; Male; Nitric Oxide Synthase; Penis; Rats; Rats, Wistar; Vitamin B 12 | 2012 |
Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in alopecia areata patients.
Topics: Adolescent; Adult; Aged; Alopecia Areata; Child; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Male; Middle Aged; Transcobalamins; Vitamin B 12; Young Adult | 2013 |
High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Area Under Curve; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Folic Acid; Homocysteine; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Stereotyped Behavior; Vitamin B Complex | 2012 |
Homocysteine and cardiovascular risk: the perils of reductionism in a complex system.
Topics: Animals; Coronary Disease; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk; Vitamin B Complex | 2012 |
Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia.
Topics: Animals; Apoptosis Regulatory Proteins; Blotting, Western; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Chromatography, Gel; Cytoskeletal Proteins; Diet; Folic Acid; Homocysteine; Hyperhomocysteinemia; Inflammasomes; Interleukin-1beta; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Electron, Transmission; NLR Family, Pyrin Domain-Containing 3 Protein; Podocytes; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sclerosis; Vascular Endothelial Growth Factor A | 2012 |
Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.
Topics: Adult; Carbon; Cardiovascular Diseases; Folic Acid; gamma-Glutamyl Hydrolase; Genetic Association Studies; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Regression Analysis; Risk Factors; Thymidylate Synthase; White People | 2012 |
Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians.
Topics: Adult; Cholesterol; Coronary Artery Disease; Female; Folic Acid; Genetic Association Studies; Homocysteine; Humans; Hyperhomocysteinemia; India; Lipoproteins, HDL; Lipoproteins, LDL; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Smoking; Triglycerides; Vitamin B 12 | 2012 |
Effects of alcohol, lithium, and homocysteine on nonmuscle myosin-II in the mouse placenta and human trophoblasts.
Topics: Animals; Cell Line; Cell Movement; Central Nervous System Depressants; Endothelial Cells; Ethanol; Female; Folic Acid; Homocysteine; Humans; Inositol; Lithium Compounds; Maternal Exposure; Mice; Nonmuscle Myosin Type IIA; Nonmuscle Myosin Type IIB; Placenta; Placental Circulation; Pregnancy; Trophoblasts; Ultrasonography, Doppler; Umbilical Cord; Vitamin B Complex | 2012 |
Plasma phospholipid polyunsaturated fatty acids and homocysteine in Chinese type 2 diabetes patients.
Topics: Adult; Aged; Algorithms; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Outpatient Clinics, Hospital; Phospholipids; Prevalence; Vitamin B 12 | 2012 |
Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Line; Cell Movement; Cell Survival; Cells, Cultured; Folic Acid; Folic Acid Deficiency; Hep G2 Cells; Hippocampus; Homocysteine; Humans; Immunohistochemistry; Neurons; Protein Binding; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Vitamin B 12 | 2012 |
Cervical cancer pathogenesis is associated with one-carbon metabolism.
Topics: Adult; Aged; Antigens, CD; Cadherins; Carbon; DNA Methylation; Female; Folic Acid; Genotype; Homocysteine; Humans; Kruppel-Like Transcription Factors; Middle Aged; Papillomaviridae; Papillomavirus Infections; Receptors, Retinoic Acid; Uterine Cervical Neoplasms; Vitamin B 12 | 2012 |
Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults.
Topics: Adult; Aged; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Depression; Female; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Vitamin B 12; Vitamin B 6 | 2012 |
Reduced folate, increased vitamin B(12) and homocysteine concentrations in women delivering preterm.
Topics: Adult; Birth Weight; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Maternal Nutritional Physiological Phenomena; Micronutrients; Nutrition Assessment; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Premature Birth; Vitamin B 12; Vitamin B Complex; Young Adult | 2012 |
Homocysteine, folate and pregnancy outcomes.
Topics: Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Infant, Small for Gestational Age; Logistic Models; Pregnancy; Pregnancy Complications; Pregnancy Outcome | 2012 |
[The relation between plasma homocysteine level and amyotrophic lateral sclerosis].
Topics: Adult; Amyotrophic Lateral Sclerosis; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12 | 2012 |
Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Fluoxetine; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Prevalence; Psychiatric Status Rating Scales; Statistics, Nonparametric; Vitamin B 12; Young Adult | 2012 |
Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline Deficiency; Dietary Supplements; Enzyme Inhibitors; Folic Acid; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Liver; Male; Rats; Rats, Wistar; Sarcosine | 2012 |
Gender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults.
Topics: Adult; Aged; Betaine-Homocysteine S-Methyltransferase; Cholesterol Ester Transfer Proteins; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Predictive Value of Tests; Reference Values; Retinol-Binding Proteins, Cellular; Risk Factors; Scavenger Receptors, Class B; Serine C-Palmitoyltransferase; Sex Distribution | 2012 |
Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligo.
Topics: Adolescent; Adult; Child; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Vitamin B 12; Vitiligo | 2012 |
Unmetabolized folic acid prevalence is widespread in the older Irish population despite the lack of a mandatory fortification program.
Topics: Aged; Aged, 80 and over; Aging; Cohort Studies; Cross-Sectional Studies; Diet; Erythrocytes; Female; Folic Acid; Food, Fortified; Health Promotion; Homocysteine; Humans; Ireland; Male; Middle Aged; Nutrition Policy; Vitamin B 12; Vitamin B 12 Deficiency; Voluntary Programs | 2012 |
Homocysteine, folate, vitamin B12 and B6 in mothers of children with neural tube defects in Xinjiang, China.
Topics: Adult; Biomarkers; Case-Control Studies; China; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Neural Tube Defects; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Risk Factors; Vitamin B 12; Vitamin B 6 | 2012 |
Higher plasma homocysteine is associated with lower vitamin B6 status in critically ill surgical patients.
Topics: Aged; Critical Illness; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intensive Care Units; Male; Middle Aged; Nutritional Status; Postoperative Complications; Prevalence; Pyridoxal Phosphate; Vitamin B 12; Vitamin B 6 Deficiency; Vitamin B Complex | 2012 |
Association between ischemia-modified albumin, homocysteine, vitamin B(12) and folic acid in patients with severe sepsis.
Topics: Adolescent; Adult; Aged; Bacteremia; Biomarkers; C-Reactive Protein; Case-Control Studies; Female; Folic Acid; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Homocysteine; Humans; Male; Middle Aged; Serum Albumin; Serum Albumin, Human; Vitamin B 12; Young Adult | 2012 |
Effects of unconjugated bilirubin on chromosomal damage in individuals with Gilbert's syndrome measured with the micronucleus cytome assay.
Topics: Adult; Aged; Aged, 80 and over; Bilirubin; Chromosome Aberrations; Colorectal Neoplasms; Comet Assay; Cytokinesis; DNA Damage; Endpoint Determination; Female; Folic Acid; Gilbert Disease; Homocysteine; Humans; Lung Neoplasms; Lymphocytes; Male; Micronucleus Tests; Middle Aged; Vitamin B 12; Young Adult | 2012 |
Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.
Topics: Catechol O-Methyltransferase; Cognition Disorders; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Parkinson Disease; Polymorphism, Genetic; Reduced Folate Carrier Protein; Vitamin B 12 | 2012 |
Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome.
Topics: Adolescent; Adult; Brazil; Child; Child, Preschool; Chromosomes, Human, Pair 21; Down Syndrome; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genotype; Homocysteine; Humans; Infant; Linear Models; Male; Methylmalonic Acid; Polymorphism, Genetic; Sequence Analysis, DNA; Vitamin B 12 Deficiency; Young Adult | 2012 |
[Abnormal findings during newborn period of 160 patients with early-onset methylmalonic aciduria].
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Child; Child, Preschool; China; Female; Folic Acid; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Infant, Newborn; Male; Methylmalonic Acid; Neonatal Screening; Retrospective Studies; Vitamin B 12 | 2012 |
Do all the patients with gastric parietal cell antibodies have pernicious anemia?
Topics: Adult; Aged; Aged, 80 and over; Anemia, Pernicious; Antibodies; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Hematinics; Hemoglobins; Homocysteine; Humans; Intrinsic Factor; Iron; Male; Middle Aged; Parietal Cells, Gastric; Sex Factors; Vitamin B 12; World Health Organization; Young Adult | 2013 |
Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid.
Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Immunoassay; Male; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Vitamin B 12 | 2012 |
Serum homocysteine and folate concentrations among a US cohort of adolescents before and after folic acid fortification.
Topics: Adolescent; Body Mass Index; Edible Grain; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Male; Nutritional Status; Outcome Assessment, Health Care; Sex Factors; United States; Vitamin B 6; Vitamin B Complex | 2012 |
Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements.
Topics: Adult; Biomarkers; Dietary Supplements; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Methylmalonic Acid; Micronutrients; Norway; Pregnancy; Prospective Studies; Riboflavin; Socioeconomic Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2013 |
Elevated plasma homocysteine level is not primarily related to Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Case-Control Studies; Cognitive Dysfunction; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Renal Insufficiency; Risk Factors; Vascular Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 2012 |
Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Body Weight; Cysteine; Diet; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Mice; Mice, Knockout; Organ Size | 2012 |
Antiepileptic drugs and the fetal epigenome.
Topics: Anticonvulsants; Birth Weight; Case-Control Studies; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Epilepsy; Female; Fetal Blood; Fetus; Folic Acid; Homocysteine; Humans; Oligonucleotide Array Sequence Analysis; Pregnancy; Pregnancy Complications | 2013 |
Relationship of cognitive function with B vitamin status, homocysteine, and tissue factor pathway inhibitor in cognitively impaired elderly: a cross-sectional survey.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins; Male; Mental Status Schedule; Neuropsychological Tests; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Associations between maternal genotypes and metabolites implicated in congenital heart defects.
Topics: Adult; Asymptomatic Diseases; Carbon-Nitrogen Ligases; Case-Control Studies; Catalase; DNA (Cytosine-5-)-Methyltransferases; DNA Modification Methylases; DNA Repair Enzymes; Female; Folic Acid; Genotype; Glutathione; Glutathione Peroxidase; Heart Defects, Congenital; Homocysteine; Humans; Life Style; Male; Methionine; Methionine Adenosyltransferase; Polymorphism, Single Nucleotide; Risk; Tumor Suppressor Proteins | 2012 |
Efficacy of a 28-day oral cyanocobalamin supplementation on vitamin B status in Spanish institutionalized elderly.
Topics: Aged; Aged, 80 and over; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Institutionalization; Male; Nutritional Status; Spain; Transcobalamins; Vitamin B 12; Vitamin B Deficiency | 2012 |
High homocysteine and low folate concentrations in acute aortic dissection.
Topics: Adult; Aged; Aortic Aneurysm; Aortic Dissection; Biomarkers; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies | 2013 |
Homocysteine, folic acid and vitamin B12 levels in females with severe acne vulgaris.
Topics: Acne Vulgaris; Female; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2012 |
Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain.
Topics: Abortion, Spontaneous; Adult; Case-Control Studies; Erythrocytes; Female; Folic Acid; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Odds Ratio; Polymorphism, Single Nucleotide; Spain; Vitamin B 12 | 2013 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Interferon-gamma; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Transgenic; Muscle Spasticity; Placenta; Pregnancy; Pregnancy Complications; Psychotic Disorders; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 2013 |
Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.
Topics: Animals; Arsenates; Cross-Over Studies; Diet; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Random Allocation; Sulfathiazoles | 2012 |
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients.
Topics: Adult; Aged; Aged, 80 and over; Atrophy; Dietary Supplements; Female; Folic Acid; Glossitis; Hematinics; Homocysteine; Humans; Iron; Male; Middle Aged; Tongue; Vitamin B 12; Vitamin B Complex; Young Adult | 2013 |
DNA damage response in monozygotic twins discordant for smoking habits.
Topics: Apoptosis; Comet Assay; Cross-Sectional Studies; DNA Damage; DNA Repair; Endpoint Determination; Environmental Exposure; Female; Folic Acid; Gamma Rays; Histones; Homocysteine; Humans; Kinetics; Linear Models; Lymphocytes; Male; Phosphorylation; Radiation Tolerance; Smoking; Twins, Monozygotic; Vitamin B 12 | 2013 |
Plasma homocysteine levels in dry eye patients.
Topics: Dry Eye Syndromes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunoenzyme Techniques; Luminescent Measurements; Male; Middle Aged; Prospective Studies; Surveys and Questionnaires; Vitamin B 12 | 2013 |
Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Gait; Geriatric Assessment; Homocysteine; Humans; Hyperhomocysteinemia; Longitudinal Studies; Male; Middle Aged; Mobility Limitation; Postural Balance; Prospective Studies; Singapore; Vitamin B 12; Vitamin B 12 Deficiency | 2012 |
Lowering homocysteine levels may prevent cardiovascular impairments? Possible therapeutic behaviors.
Topics: Acetylcysteine; Aspirin; Blood Vessels; Cardiovascular Diseases; Clopidogrel; Diuretics; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Platelet Aggregation Inhibitors; S-Adenosylmethionine; Ticlopidine; Vitamin B 12; Vitamin B 6 | 2012 |
The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model.
Topics: Cystathionine beta-Synthase; Down Syndrome; Folic Acid; Folic Acid Deficiency; Half-Life; Homocysteine; Humans; Methionine; Methylation; Models, Theoretical; Nutrition Surveys; Nutritional Status; Oxidative Stress; S-Adenosylmethionine; Vitamin B 12 Deficiency; Vitamin B Complex; Vitamins | 2013 |
Acute myocardial infarction in a young patient with hyperhomocysteinaemia.
Topics: Acute Disease; Adult; Betaine; Coronary Vessels; Folic Acid; Heart; Homocysteine; Humans; Hyperhomocysteinemia; Male; Myocardial Infarction; Myocardium; Thrombosis; Troponin; Ventricular Function, Left | 2012 |
Aqueous humor glycation marker and plasma homocysteine in macular degeneration.
Topics: Aged; Aged, 80 and over; Aqueous Humor; Cataract; Female; Folic Acid; Glycation End Products, Advanced; Homocysteine; Humans; Hypertension; Macular Degeneration; Male; Middle Aged | 2013 |
Oxidative stress in coronary artery disease: epigenetic perspective.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line; Coronary Artery Disease; Decitabine; DNA Methylation; Endothelial Cells; Epigenesis, Genetic; Female; Ferredoxin-NADP Reductase; Folic Acid; Glutathione S-Transferase pi; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Hydroxamic Acids; Male; Malondialdehyde; Membrane Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidative Stress; Promoter Regions, Genetic; Protein Carbonylation; Proto-Oncogene Proteins; Superoxide Dismutase; Young Adult | 2013 |
Gender and age influence blood folate, vitamin B12, vitamin B6, and homocysteine levels in European adolescents: the Helena Study.
Topics: Adolescent; Age Factors; Child; Cross-Sectional Studies; Europe; Female; Folic Acid; Homocysteine; Humans; Male; Nutritional Status; Reference Values; Sex Factors; Vitamin B 12; Vitamin B 6 | 2012 |
Total blood mercury and rubella antibody concentrations in US children aged 6-11 years, NHANES 2003-2004.
Topics: Antibodies, Viral; Child; Cross-Sectional Studies; Environmental Pollutants; Female; Folic Acid; Homocysteine; Humans; Immunoglobulin G; Linear Models; Male; Measles; Mercury; Methylmalonic Acid; Nutrition Surveys; United States; Vitamin B 12 | 2013 |
Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk.
Topics: Aged; Biomarkers; Brain Infarction; Brain Ischemia; Case-Control Studies; Chi-Square Distribution; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Humans; Logistic Models; Magnetic Resonance Imaging; Male; MicroRNAs; Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Prevalence; Republic of Korea; Risk Assessment; Risk Factors | 2013 |
Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.
Topics: Administration, Oral; Animals; Catalase; Cycas; Diet; Dietary Supplements; Folic Acid; Glutathione Peroxidase; Heart; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tocotrienols | 2013 |
The effects of normalizing hyperhomocysteinemia on clinical and operative outcomes in patients with critical limb ischemia.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Biomarkers; Chi-Square Distribution; Critical Illness; Disease-Free Survival; Drug Therapy, Combination; Endovascular Procedures; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Hyperhomocysteinemia; Ischemia; Kaplan-Meier Estimate; Limb Salvage; Logistic Models; Lower Extremity; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Risk Factors; Time Factors; Treatment Outcome; Vascular Patency; Vitamin B 12; Vitamin B Complex | 2012 |
Association of homocysteine levels with blood lead levels and micronutrients in the US general population.
Topics: Adult; Aged; Female; Folic Acid; Homocysteine; Humans; Lead; Male; Micronutrients; Middle Aged; Nutrition Surveys; Odds Ratio; United States; Vitamin B 12; Vitamin B 6 | 2012 |
Effect of carbamazepine therapy on homocysteine, vitamin B12 and folic acid levels in children with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Neurocysticercosis; Prospective Studies; Vitamin B 12 | 2013 |
Efficacy of adding folic acid to foods.
Topics: Cardiovascular Diseases; Diet; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; Neoplasms; Neural Tube Defects; Vitamin B 12 Deficiency | 2012 |
Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study).
Topics: Cohort Studies; Colorectal Neoplasms; Diet; Erythrocytes; Female; Folic Acid; Glutathione Reductase; Homocysteine; Humans; Intestinal Mucosa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Assessment; Nutritional Status; Risk Factors; Surveys and Questionnaires; Tetrahydrofolates; Vitamin B 12 | 2013 |
Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism.
Topics: Autistic Disorder; Case-Control Studies; Child, Preschool; Diet; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Nutrition Assessment; Nutritional Status; Odds Ratio; Oman; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Significant reduction of serum homocysteine level and oral symptoms after different vitamin-supplement treatments in patients with burning mouth syndrome.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Burning Mouth Syndrome; Calcium; Female; Ferric Compounds; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Hematinics; Hemoglobins; Homocysteine; Humans; Iron; Male; Middle Aged; Niacinamide; Pantothenic Acid; Remission Induction; Riboflavin; Thiamine; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B Complex | 2013 |
Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism).
Topics: Alleles; Blood Glucose; Dietary Supplements; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Lipid Metabolism; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Poland; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Surveys and Questionnaires; Waist-Hip Ratio; White People | 2013 |
Serum factors associated with precancerous colonic lesions in acromegaly.
Topics: Acromegaly; Adenoma; Adult; Aged; Calcifediol; Cohort Studies; Colonic Neoplasms; Colonic Polyps; Colonoscopy; Fasting; Female; Folic Acid; Homocysteine; Humans; Insulin; Male; Middle Aged; Precancerous Conditions; Somatostatin | 2013 |
[Correlation between plasma concentrations of homocysteine and diabetic polyneuropathy evaluated with the Semmes-Weinstein monofilament test in patients with type 2 diabetes mellitus].
Topics: Age Factors; Aged; Alcohol Drinking; Cardiovascular Diseases; Case-Control Studies; Creatinine; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Progression; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Hyperhomocysteinemia; Hypesthesia; Hypoglycemic Agents; Hypolipidemic Agents; Male; Middle Aged; Overweight; Physical Examination; Risk Factors; Severity of Illness Index; Smoking; Vitamin B 12 | 2013 |
Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults.
Topics: Age Factors; Aged; Asian People; Brain; Cardiovascular Diseases; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Fibers, Myelinated; Neuropsychological Tests; Organ Size; Singapore; Vitamin B 12 | 2013 |
Vitamin B(12) intake and status in early pregnancy among urban South Indian women.
Topics: Adolescent; Adult; Anthropometry; Cross-Sectional Studies; Diet; Dietary Supplements; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; India; Methylmalonic Acid; Nutritional Status; Parity; Pregnancy; Prevalence; Socioeconomic Factors; Surveys and Questionnaires; Urban Population; Vitamin B 12; Vitamin B 12 Deficiency; White People; Young Adult | 2013 |
Reliability of selected antioxidants and compounds involved in one-carbon metabolism in two Dutch cohorts.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Biomarkers; Carbon; Carotenoids; Cohort Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Netherlands; Nutritional Status; Tocopherols; Vitamin A; Vitamin B 12; Vitamin B 6; Young Adult | 2013 |
Association between plasma biomarkers, CDK5 polymorphism and the risk of Alzheimer's disease.
Topics: Alzheimer Disease; Apolipoproteins E; Cyclin-Dependent Kinase 5; Female; Folic Acid; Genetic Association Studies; Genotype; Homocysteine; Humans; Lipids; Male; Meta-Analysis as Topic; Middle Aged; Polymorphism, Genetic; Riboflavin | 2012 |
Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Anticonvulsants; Cystathionine beta-Synthase; Epilepsy; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Tetrahydrofolate Dehydrogenase; Transcobalamins; Vitamin B 12 | 2013 |
Association between hypocobalaminaemia and hyperhomocysteinaemia in dogs.
Topics: Animals; Breeding; Dog Diseases; Dogs; Female; Folic Acid; Gastrointestinal Diseases; Homocysteine; Hyperhomocysteinemia; Male; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome.
Topics: Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Female; Folic Acid; Gene Deletion; Gene Frequency; Genotype; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Infant; Male; Methylmalonic Acid; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Young Adult | 2013 |
Homocysteine levels in patients with primary and secondary Raynaud's phenomenon. Its association with microangiopathy severity.
Topics: Adult; Aged; Capillaries; Female; Folic Acid; Homocysteine; Humans; Microcirculation; Middle Aged; Raynaud Disease; Vitamin B 12; Young Adult | 2014 |
Molecular mechanisms underlying the anti-proliferative and anti-migratory effects of folate on homocysteine-challenged rat aortic smooth muscle cells.
Topics: Animals; Aorta; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Folic Acid; Gene Expression Regulation; Homocysteine; Male; Myocytes, Smooth Muscle; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction | 2013 |
Higher plasma homocysteine is associated with increased risk of developing colorectal polyps.
Topics: Case-Control Studies; Colonic Polyps; Confidence Intervals; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pyridoxal Phosphate; Risk Factors; Taiwan; Vitamin B 12; Vitamin B Complex | 2013 |
[Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder].
Topics: Bipolar Disorder; Case-Control Studies; Cognition; Folic Acid; Homocysteine; Humans; Methionine; Psychiatric Status Rating Scales; Severity of Illness Index; Vitamin B 12 | 2013 |
Effect of maternal and postweaning folic acid supplementation on global and gene-specific DNA methylation in the liver of the rat offspring.
Topics: Animals; Animals, Newborn; Diet; Dietary Supplements; DNA Methylation; Female; Folic Acid; Homocysteine; Liver; PPAR gamma; Pregnancy; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Weaning | 2013 |
Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Coronary Artery Disease; Dyslipidemias; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort.
Topics: Adult; Aged; Case-Control Studies; Confidence Intervals; Folic Acid; Genotype; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Norway; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Population Surveillance; Prospective Studies; Prostatic Neoplasms; Risk Factors; Socioeconomic Factors; Vitamin B 12 | 2013 |
Advanced age as a risk factor for folate-associated functional cobalamin deficiency.
Topics: Aged; Aged, 80 and over; Causality; Cognition Disorders; Comorbidity; Female; Folic Acid; Geriatric Assessment; Homocysteine; Humans; Male; Methylmalonic Acid; Risk Factors; Severity of Illness Index; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis.
Topics: Adult; alpha-Tocopherol; Ascorbic Acid; Biomarkers; Body Mass Index; Carotenoids; Cross-Sectional Studies; Factor Analysis, Statistical; Fatty Acids, Essential; Female; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Micronutrients; Nutritional Status; Obesity; Pregnancy; Prospective Studies; Receptors, Transferrin; Vitamin A; Vitamin D; Women's Health; Young Adult | 2013 |
Re. Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism).
Topics: Blood Glucose; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lipid Metabolism; Methylenetetrahydrofolate Reductase (NADPH2) | 2013 |
Maternal first-trimester dietary intake and childhood blood pressure: the Generation R Study.
Topics: Blood Pressure; Child; Cohort Studies; Diet; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Maternal Nutritional Physiological Phenomena; Micronutrients; Netherlands; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Vitamin B 12 | 2013 |
The distribution of serum folate concentration and red blood cell indices in alcoholics.
Topics: Adult; Aged; Alcohol Drinking; Alcoholics; Alcoholism; Case-Control Studies; Erythrocytes; Ethanol; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemoglobins; Homocysteine; Humans; Male; Middle Aged; Poland; Vitamin B 12; Young Adult | 2013 |
Plasmatic higher levels of homocysteine in non-alcoholic fatty liver disease (NAFLD).
Topics: Adult; Biomarkers; Brazil; Cholesterol; Chronic Disease; Fatty Liver; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Leukocytes, Mononuclear; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Non-alcoholic Fatty Liver Disease; Polymorphism, Genetic; Triglycerides; Vitamin B 12 | 2013 |
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
Topics: Adolescent; Adult; Betaine; Biomarkers; Choline; Cysteine; Diet; Diet Records; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; DNA Methylation; Feeding Behavior; Female; Folic Acid; Gambia; Homocysteine; Humans; Linear Models; Methionine; Middle Aged; Nutrition Assessment; Prospective Studies; Riboflavin; Rural Population; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Vitamin B 12; Vitamin B 6; Young Adult | 2013 |
High cortisol and low folate are the only routine blood tests predicting probable Alzheimer's disease after age 75-results of the Vienna Transdanube Aging Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Apolipoprotein E4; Austria; Cohort Studies; Confidence Intervals; Diagnostic Tests, Routine; Female; Folic Acid; Hematologic Tests; Homocysteine; Humans; Hydrocortisone; Longitudinal Studies; Male; Odds Ratio; Prognosis; Risk Factors | 2013 |
Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine.
Topics: Adult; Betaine; Choline; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Nutritional Status; Pregnancy; Sarcosine; Spain; Vitamin B 12 | 2013 |
Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude.
Topics: Adolescent; Adult; Altitude; Case-Control Studies; Erythrocytes; Female; Folic Acid; Gravidity; Hematocrit; Homocysteine; Humans; Pilot Projects; Pre-Eclampsia; Pregnancy; Young Adult | 2013 |
MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among North Indian women.
Topics: Abortion, Habitual; Adolescent; Adult; Amino Acid Substitution; Case-Control Studies; Female; Folic Acid; Gene Frequency; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; India; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2013 |
Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population.
Topics: Adult; Air Pollutants, Occupational; Biomarkers, Tumor; Chromium; Environmental Monitoring; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Occupational Exposure; Smoking; Young Adult | 2014 |
Homocysteine, antioxidant micronutrients and late onset dementia.
Topics: Aged; Aged, 80 and over; Antioxidants; Body Mass Index; Cognition; Dementia; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Micronutrients; Nutrition Assessment; Proportional Hazards Models; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Vitamin B 12 | 2014 |
Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular degeneration.
Topics: Aged; Animals; Female; Fishes; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Incidence; Leukocyte Count; Macular Degeneration; Male; Middle Aged; Prospective Studies; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Impact of gluten-free diet on cardiovascular risk factors. A retrospective analysis in a large cohort of coeliac patients.
Topics: Adult; Body Mass Index; Cardiovascular Diseases; Celiac Disease; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet, Gluten-Free; Female; Folic Acid; gamma-Glutamyltransferase; Homocysteine; Humans; Insulin Resistance; Male; Middle Aged; Retrospective Studies; Risk Factors; Triglycerides; Vitamin B 12; Young Adult | 2013 |
The heart-placenta axis in the first month of pregnancy: induction and prevention of cardiovascular birth defects.
Topics: Animals; Birds; Cell Differentiation; Dietary Supplements; Disease Models, Animal; Ethanol; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Heart; Heart Defects, Congenital; Homocysteine; Humans; Lithium Compounds; Maternal Exposure; Mice; Myocytes, Cardiac; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Signal Transduction; Wnt Proteins | 2013 |
Neonatal folate, homocysteine, vitamin B12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema.
Topics: Asthma; Biomarkers; Child; Child, Preschool; Dermatitis, Atopic; Female; Fetal Blood; Folic Acid; Follow-Up Studies; Genetic Markers; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Linear Models; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Prospective Studies; Surveys and Questionnaires; Vitamin B 12 | 2013 |
Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population.
Topics: Adult; Apolipoprotein A-I; Apolipoproteins B; Female; Folic Acid; Genetic Association Studies; Genetics, Population; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Polymorphism, Genetic; Risk Factors; Vitamin B 12 | 2013 |
Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Fear; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation; Glycine Hydroxymethyltransferase; Hippocampus; Homocysteine; In Situ Hybridization; Male; Memory; Mice; Mice, Knockout; Neurogenesis; Neurons; Risk Factors; Thymidine Monophosphate | 2013 |
Maternal first-trimester diet and childhood bone mass: the Generation R Study.
Topics: Absorptiometry, Photon; Adult; Bone Density; Calcium, Dietary; Child; Diet; Female; Folic Acid; Homocysteine; Humans; Life Style; Magnesium; Male; Maternal Nutritional Physiological Phenomena; Phosphorus, Dietary; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Socioeconomic Factors; Surveys and Questionnaires; Vitamin B 12 | 2013 |
Plasma homocysteine and folate levels and dietary folate intake in adolescents and young adults who underwent kidney transplantation during childhood.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Age Factors; Biomarkers; Cardiovascular Diseases; Child; Child Nutritional Physiological Phenomena; Cross-Sectional Studies; Diet; Female; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Japan; Kidney; Kidney Transplantation; Linear Models; Male; Nutrition Assessment; Nutritional Status; Prevalence; Risk Factors; Time Factors; Treatment Outcome; Vitamin B Deficiency; Young Adult | 2014 |
Should we be taking B vitamins to prevent age-related macular degeneration? Not yet, but worth doing more research.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Macular Degeneration; Male; Vitamin B 12 | 2013 |
Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model.
Topics: Absorption; Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Disease Models, Animal; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Physical Conditioning, Animal | 2013 |
Homocysteine, vitamin B12 and folate levels in Iranian patients with Multiple Sclerosis: a case control study.
Topics: Adult; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Interferon-beta; Iran; Male; Multiple Sclerosis, Chronic Progressive; Prospective Studies; Vitamin B 12 | 2013 |
Are vitamin B(12) levels really increased in women delivering preterm?
Topics: Female; Folic Acid; Homocysteine; Humans; Maternal Nutritional Physiological Phenomena; Pregnancy; Premature Birth; Vitamin B 12; Vitamin B Complex | 2013 |
[Association study for gene polymorphism of folic acid/homocysteine metabolic pathway and nonsyndromic cleft lip with or without cleft palate in Chinese populations].
Topics: Asian People; Cleft Lip; Cleft Palate; Folic Acid; Genetic Linkage; Genome-Wide Association Study; Homocysteine; Humans; Logistic Models; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide; Risk Factors | 2013 |
A prospective study of maternal fatty acids, micronutrients and homocysteine and their association with birth outcome.
Topics: Adult; Birth Weight; Chromatography, Gas; Fatty Acids; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; India; Longitudinal Studies; Luminescent Measurements; Micronutrients; Mothers; Pregnancy; Prospective Studies; Vitamin B 12; Young Adult | 2015 |
Nutrition throughout life: folate.
Topics: Biological Availability; Cardiovascular Diseases; Drug Stability; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Neural Tube Defects; Nutrition Policy; Nutritional Physiological Phenomena; Nutritional Requirements; Nutritional Status; Pregnancy | 2012 |
Serum vitamin B6, folate, and homocysteine concentrations and oxidative DNA damage in Japanese men and women.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Asian People; Biomarkers; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Deoxyguanosine; DNA Damage; Female; Folic Acid; Homocysteine; Humans; Japan; Linear Models; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Pyridoxal; Vitamin B 6; Young Adult | 2013 |
Effect of multivitamins on plasma homocysteine in patients with the 5,10 methylenetetrahydrofolate reductase C677T homozygous state.
Topics: Adult; Female; Folic Acid; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Vitamin B 12; Vitamins | 2013 |
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and variations of homocysteine concentrations in patients with Behcet's disease.
Topics: Adult; Behcet Syndrome; Case-Control Studies; Cobamides; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Young Adult | 2013 |
[The clinical studies of hyperhomocysteinemia and Alzheimer's disease].
Topics: Alzheimer Disease; Case-Control Studies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia | 2013 |
Are plasma homocysteine concentrations in Brazilian adolescents influenced by the intake of the main food sources of natural folate?
Topics: Adolescent; Brazil; Cross-Sectional Studies; Diet Records; Fabaceae; Feeding Behavior; Female; Folic Acid; Fruit; Homocysteine; Humans; Linear Models; Male; Sex Factors; Vegetables | 2013 |
Early biochemical and hematological response to intramuscular cyanocobalamin therapy in vitamin B(12)-deficient patients.
Topics: Aged; Chromatography, High Pressure Liquid; Cysteine; Erythrocyte Indices; Female; Folic Acid; Homocysteine; Humans; Injections, Intramuscular; Male; Methionine; Methylmalonic Acid; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Prenatal omega 3 fatty acid supplementation to a micronutrient imbalanced diet protects brain neurotrophins in both the cortex and hippocampus in the adult rat offspring.
Topics: Animal Nutritional Physiological Phenomena; Animals; Brain; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cognition; Diet; Dietary Supplements; Fatty Acids, Omega-3; Female; Folic Acid; Folic Acid Deficiency; Hippocampus; Homocysteine; Maze Learning; Micronutrients; Nerve Growth Factor; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
A population model of folate-mediated one-carbon metabolism.
Topics: Carbon; Diet; Folic Acid; Homocysteine; Humans; Liver; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Models, Theoretical; Nutrition Surveys; Oxidative Stress; Polymorphism, Genetic | 2013 |
Folic acid attenuates hyperhomocysteinemia-induced glomerular damage in rats.
Topics: Albuminuria; Animals; Cell Proliferation; Collagen; Creatinine; Folic Acid; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Kidney; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Podocytes; Random Allocation; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Up-Regulation | 2013 |
Plasma homocysteine concentrations in the acute phase after central retinal vein occlusion in a Chinese population.
Topics: Acute Disease; Aged; Asian People; Cardiovascular Diseases; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2013 |
Influence of maternal vitamin B12 and folate on growth and insulin resistance in the offspring.
Topics: Adiposity; Adolescent; Adult; Animals; Body Weight; Carbon; Cardiovascular Diseases; Child; Chronic Disease; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Growth; Homocysteine; Humans; India; Infant; Infant, Newborn; Insulin Resistance; Maternal Nutritional Physiological Phenomena; Neural Tube Defects; Nutritional Status; Pregnancy; Pregnancy Complications; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2013 |
Determinants of plasma homocysteine in coal miners.
Topics: Adult; Body Mass Index; Case-Control Studies; Coal Mining; Cystatin C; Folic Acid; Homocysteine; Humans; Luminescent Measurements; Male; Middle Aged; Occupational Exposure; Risk Factors; Urea; Vitamin B 12 | 2013 |
Homocysteine levels and dementia risk in Yoruba and African Americans.
Topics: Aged; Aged, 80 and over; Black or African American; Black People; Dementia; Female; Folic Acid; Homocysteine; Humans; Incidence; Indiana; Longitudinal Studies; Male; Neuropsychological Tests; Nigeria; Vitamin B 12 | 2013 |
Genetic association of five plasminogen activator inhibitor-1 (PAI-1) polymorphisms and idiopathic recurrent pregnancy loss in Korean women.
Topics: Abortion, Habitual; Adult; Blood Coagulation; DNA Mutational Analysis; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Korea; Middle Aged; Mutation; Plasminogen Activator Inhibitor 1; Polymorphism, Genetic; Pregnancy; Young Adult | 2013 |
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil | 2014 |
Author response.
Topics: Blood Glucose; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lipid Metabolism; Methylenetetrahydrofolate Reductase (NADPH2) | 2013 |
Low birthweight (LBW) and neonatal hyperbilirubinemia (NNH) in an Indian cohort: association of homocysteine, its metabolic pathway genes and micronutrients as risk factors.
Topics: Cohort Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperbilirubinemia, Neonatal; Incidence; India; Infant, Low Birth Weight; Infant, Newborn; Male; Micronutrients; Pregnancy; Risk Factors; Vitamin B 12 | 2013 |
Dyslipidemia in pediatric systemic lupus erythematosus: the relationship with disease activity and plasma homocysteine and cysteine concentrations.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Child; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studies; Cysteine; Dyslipidemias; Energy Intake; Female; Folic Acid; Homocysteine; Humans; Lupus Erythematosus, Systemic; Multivariate Analysis; Nutritional Status; Puberty; Risk Factors; Triglycerides; Vitamin B 12; Waist Circumference; Young Adult | 2013 |
Low calcium intake is associated with high plasma homocysteine levels in postmenopausal women.
Topics: Aged; Calcium, Dietary; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Nutritional Status; Postmenopause | 2014 |
[Evaluation of the interdependence between homocystein and folic acid levels in patients after kidney transplantation during a 2 year observation period].
Topics: Adolescent; Adult; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Peritoneal Dialysis; Renal Dialysis; Young Adult | 2013 |
Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer.
Topics: Adult; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Breast Neoplasms; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Kazakhstan; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Proteins | 2013 |
Serum folate, homocysteine, brain atrophy, and auto-CM system: The Treviso Dementia (TREDEM) study.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Brain; Brain Mapping; Disability Evaluation; Female; Folic Acid; Homocysteine; Humans; Italy; Male; Middle Aged; Neuroimaging; Neuropsychological Tests; Outpatients; Retrospective Studies | 2014 |
Dietary folate intake and blood biomarkers reveal high-risk groups in a Mediterranean population of healthy women of childbearing potential.
Topics: Adolescent; Adult; Alleles; Biomarkers; Cross-Sectional Studies; Diet; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Mediterranean Region; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Assessment; Polymorphism, Genetic; Surveys and Questionnaires; Young Adult | 2013 |
Nutrients related to the incidence of early and late age-related macular degeneration.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Macular Degeneration; Male; Vitamin B 12 | 2013 |
Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimens.
Topics: Aged; Antiparkinson Agents; Cross-Sectional Studies; Electromyography; Female; Folic Acid; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Peripheral Nervous System Diseases; Prevalence; Vitamin B 12 | 2014 |
Oral manifestations and blood profile in patients with thalassemia trait.
Topics: Adult; Aged; Aged, 80 and over; Atrophy; Case-Control Studies; Erythrocyte Count; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hemoglobins; Homocysteine; Humans; Hypesthesia; Iron; Male; Middle Aged; Mouth Mucosa; Thalassemia; Tongue; Varicose Veins; Vitamin B 12; Xerostomia; Young Adult | 2013 |
Association between maternal folate concentrations during pregnancy and insulin resistance in Indian children.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; Pregnancy; Vitamin B 12; Young Adult | 2014 |
Reply to Kawada.
Topics: Animals; Female; Folic Acid; Homocysteine; Humans; Macular Degeneration; Male; Vitamin B 12 | 2013 |
Role of plasma homocysteine levels and MTHFR polymorphisms on IQ scores in children and young adults with epilepsy treated with antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Child; Cognition Disorders; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Intelligence Tests; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neuropsychological Tests; Polymorphism, Genetic; Statistics, Nonparametric; Vitamin B 12; Young Adult | 2013 |
Hyperhomocysteinemia in bipolar depression: clinical and biochemical correlates.
Topics: Adult; Aged; Biomarkers; Bipolar Disorder; E-Selectin; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intercellular Adhesion Molecule-1; Male; Middle Aged; Vitamin B 12; Young Adult | 2013 |
Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study.
Topics: Aged; Biomarkers; Cognition Disorders; Cross-Sectional Studies; Diet; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Methylmalonic Acid; Norway; Nutritional Status; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2014 |
Plasma homocysteine, folic acid, and vitamin B₁₂ levels in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and normotensive glaucoma.
Topics: Aged; Exfoliation Syndrome; Female; Folic Acid; Glaucoma; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B 12 | 2013 |
5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults.
Topics: Adult; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide | 2014 |
High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities.
Topics: Adult; Aged; Antioxidants; Blood Pressure; Body Mass Index; Case-Control Studies; Colorectal Neoplasms; Creatinine; Cysteine; Female; Folic Acid; Glutathione Peroxidase; Glutathione Transferase; Healthy Volunteers; Homocysteine; Humans; Linear Models; Male; Middle Aged; Oxidative Stress; Pyridoxal Phosphate; Risk Factors; Serum Albumin; Superoxide Dismutase | 2014 |
Homocysteine in dogs with systemic inflammatory response syndrome.
Topics: Animals; Case-Control Studies; Dog Diseases; Dogs; Female; Folic Acid; Homocysteine; Male; Sepsis; Systemic Inflammatory Response Syndrome; Vitamin B 12 | 2013 |
Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort.
Topics: Aged; Biomarkers; Choline; Cohort Studies; DNA Methylation; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Leukocytes; Middle Aged; Postmenopause | 2014 |
Homocysteine and serotonin: association with postpartum depression.
Topics: Adult; Depression, Postpartum; Female; Folic Acid; Homocysteine; Humans; Infant; Infant, Newborn; Serotonin; Vitamin B 12 | 2013 |
Serum and red blood cell folate testing for folate deficiency: new features?
Topics: Erythrocyte Indices; Erythrocytes; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Retrospective Studies; Vitamin B 12 | 2014 |
Smokeless tobacco use: a risk factor for hyperhomocysteinemia in a Pakistani population.
Topics: Adolescent; Adult; Cities; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Income; Male; Middle Aged; Pakistan; Pyridoxal Phosphate; Risk Factors; Tobacco, Smokeless; Vitamin B 12; Young Adult | 2013 |
Folic acid mitigates angiotensin-II-induced blood pressure and renal remodeling.
Topics: Angiotensin II; Animals; Arginine; Blood Pressure; Collagen; Drinking; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Hypertension; Kidney; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; RNA, Messenger; Tissue Inhibitor of Metalloproteinases | 2013 |
Systemic chemotherapy interferes in homocysteine metabolism in breast cancer patients.
Topics: Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Vitamin B 12 | 2014 |
Imbalance of folic acid and vitamin B12 is associated with birth outcome: an Indian pregnant women study.
Topics: Anthropometry; Birth Weight; Body Size; Dietary Supplements; Female; Folic Acid; Head; Hematinics; Homocysteine; Humans; India; Nutritional Requirements; Pregnancy; Pregnancy Complications; Thorax; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Young Adult | 2014 |
Homocysteine metabolism in children with idiopathic nephrotic syndrome.
Topics: Case-Control Studies; Child; Cholesterol; Cysteine; Demography; Female; Folic Acid; Homocysteine; Humans; Male; Nephrotic Syndrome; Proteinuria; Remission Induction; Serum Albumin; Vitamin B 12 | 2014 |
MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification.
Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Denmark; Dyslipidemias; Female; Folic Acid; Follow-Up Studies; Genotype; Genotyping Techniques; Homocysteine; Humans; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Stroke; Triglycerides; Vitamin B 12; Young Adult | 2014 |
Water-soluble vitamin deficiencies in complicated peptic ulcer patients soon after ulcer onset in Japan.
Topics: Adult; Aged; Aged, 80 and over; Ascorbic Acid; Cohort Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Japan; Male; Middle Aged; Peptic Ulcer; Prospective Studies; Riboflavin; Thiamine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2013 |
Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism.
Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Colon; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Male; Metabolic Networks and Pathways; Middle Aged; Polymorphism, Genetic; Promoter Regions, Genetic; Rectum; Vitamin B 12 | 2014 |
The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide; Pregnancy | 2014 |
Structural analysis of a fungal methionine synthase with substrates and inhibitors.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Candida albicans; Catalytic Domain; Crystallography, X-Ray; Folic Acid; Fungal Proteins; Homocysteine; Kinetics; Methionine; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Zinc | 2014 |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
Topics: Adult; Biomarkers; Depressive Disorder, Major; Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; South Africa; Surveys and Questionnaires | 2014 |
Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.
Topics: Adult; Bayes Theorem; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Glutamate-Cysteine Ligase; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Polymorphism, Single Nucleotide; Pregnancy; Prospective Studies; Risk Factors; Thymidylate Synthase | 2014 |
Prevalence and predictors of anemia in a population of North Indian children.
Topics: Anemia; Anemia, Iron-Deficiency; Biomarkers; Body Height; Child, Preschool; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Income; India; Infant; Iron; Iron Deficiencies; Male; Nutritional Status; Prevalence; Receptors, Transferrin; Vitamin B 12 | 2014 |
Folate and cobalamin modify associations between S-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults.
Topics: Adult; Aged; Arsenic; Arsenic Poisoning; Arsenicals; Bangladesh; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 2014 |
Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies.
Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; Biomarkers; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Hyperthyroidism; Hypothyroidism; Iron; Iron Deficiencies; Male; Middle Aged; Parietal Cells, Gastric; Thyroiditis, Autoimmune; Vitamin B 12; Vitamin B 12 Deficiency | 2014 |
Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women.
Topics: Aged; Biomarkers; C-Reactive Protein; Carbon; Chronic Disease; Cross-Sectional Studies; Cysteine; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Inflammation; Linear Models; Middle Aged; Nutritional Status; Risk Factors; Serum Amyloid A Protein; Vitamin B 12; Vitamin B 6 | 2014 |
Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population.
Topics: Aged; Aged, 80 and over; Algeria; Alzheimer Disease; Case-Control Studies; Cholesterol; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Logistic Models; Male; Risk Factors; Thyrotropin; Uric Acid; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2014 |
Elevated homocysteine level in first-episode schizophrenia patients--the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Lipoproteins, HDL; Male; Marijuana Abuse; Schizophrenia; Vitamin B 12; Young Adult | 2014 |
Effect of vitamin B deprivation during pregnancy and lactation on homocysteine metabolism and related metabolites in brain and plasma of mice offspring.
Topics: Animals; Brain; Female; Folic Acid; Homocysteine; Lactation; Male; Mice; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12; Vitamin B Deficiency | 2014 |
High-dose compared with low-dose vitamin B-12 supplement use is not associated with higher vitamin B-12 status in children, adolescents, and older adults.
Topics: Adolescent; Adult; Aged; Canada; Child; Cross-Sectional Studies; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Young Adult | 2014 |
[Posterior-predominant leukoencephalopathy which was caused by methylenetetrahydrofolate reductase deficiency and successfully treated with folic acid].
Topics: Adult; Biomarkers; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Mutation, Missense; Polymorphism, Single Nucleotide; Psychotic Disorders; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2014 |
Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility.
Topics: Adult; Dietary Supplements; Female; Fertilization in Vitro; Folic Acid; Homocysteine; Humans; Infertility, Female; Pregnancy; Pregnancy Outcome | 2014 |
Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion.
Topics: Abortion, Spontaneous; Adult; Asian People; Cholesterol; Female; Folic Acid; Genotype; Homocysteine; Humans; Polymorphism, Genetic; Receptors, Cell Surface; Transcobalamins; Uric Acid | 2014 |
High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort.
Topics: Aged; Cohort Studies; Dietary Supplements; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Leukocytes; Male; Massachusetts; Middle Aged; Telomere Shortening; Up-Regulation | 2015 |
Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease.
Topics: Adult; Aged; Betaine; Case-Control Studies; Choline; Cohort Studies; Diet; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Peripheral Arterial Disease; Proportional Hazards Models; Riboflavin; Risk Factors; Surveys and Questionnaires; Vitamin B Complex | 2014 |
Aberrant DNA methylation of the PDGF gene in homocysteine‑mediated VSMC proliferation and its underlying mechanism.
Topics: Cell Proliferation; Cells, Cultured; DNA Methylation; Folic Acid; G1 Phase Cell Cycle Checkpoints; Homocysteine; Humans; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Promoter Regions, Genetic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Umbilical Cord | 2014 |
Serum one-carbon metabolites and risk of cervical cancer.
Topics: Adult; Aged; DNA-Binding Proteins; Down-Regulation; Female; Folic Acid; Heterogeneous-Nuclear Ribonucleoproteins; Homocysteine; Humans; Middle Aged; Oncogene Proteins, Viral; Papillomavirus Infections; Repressor Proteins; Risk Factors; RNA-Binding Proteins; RNA, Messenger; Squamous Intraepithelial Lesions of the Cervix; Uterine Cervical Neoplasms; Viral Proteins; Vitamin B 12 | 2014 |
Methylenetetrahydrofolate reductase 677 genotype-specific reference values for plasma homocysteine and serum folate concentrations in korean population aged 45 to 74 years: the Namwon study.
Topics: Age Factors; Aged; Aging; Cohort Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Reference Values; Republic of Korea; Sex Factors | 2014 |
[Correlation between serum levels of homocysteine and folate and cognitive dysfunction in first-episode schizophrenics].
Topics: Adolescent; Adult; Case-Control Studies; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Schizophrenia; Vitamin B 12; Young Adult | 2014 |
Cheese 'refinement' with whey B-vitamin removal during precipitation potentially induces temporal 'functional' dietary shortage: homocysteine as a biomarker.
Topics: Adult; Biomarkers; Body Mass Index; Cheese; Diet; Dietary Supplements; Endpoint Determination; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Israel; Methionine; Middle Aged; Vitamin B 6; Vitamin B Complex | 2014 |
Quantification of folate metabolites in serum using ultraperformance liquid chromatography tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Limit of Detection; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolates | 2014 |
Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Aorta; Blood Glucose; Brachial Artery; Carbamazepine; Carotid Arteries; Cholesterol; Cholesterol, HDL; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phosphoric Monoester Hydrolases; Risk Factors; Ultrasonography; Valproic Acid; Vitamin B 12 | 2014 |
Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.
Topics: Aged; Aged, 80 and over; Bone and Bones; Cohort Studies; Cross-Sectional Studies; Diet; Environmental Exposure; Environmental Pollutants; Folic Acid; Homocysteine; Humans; Lead; Lead Poisoning; Male; Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2014 |
Plasma homocysteine concentrations in acute and convalescent changes of central retinal vein occlusion in a Chinese population.
Topics: Aged; Biomarkers; China; DNA; Electroretinography; Female; Folic Acid; Follow-Up Studies; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Male; Methylenetetrahydrofolate Reductase (NADPH2); Microscopy, Acoustic; Middle Aged; Ophthalmoscopy; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Prognosis; Retinal Vein Occlusion; Retrospective Studies; Risk Factors; Time Factors; Tomography, Optical Coherence; Vitamin B 12 | 2014 |
High‑dose folic acid improves endothelial function by increasing tetrahydrobiopterin and decreasing homocysteine levels.
Topics: Biopterins; Cells, Cultured; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Neopterin; Nitric Oxide | 2014 |
Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran.
Topics: Adult; Biomarkers; Blood Urea Nitrogen; Chi-Square Distribution; Creatinine; Cross-Sectional Studies; Cyclosporine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Iran; Kidney Failure, Chronic; Kidney Transplantation; Linear Models; Male; Middle Aged; Multivariate Analysis; Prevalence; Risk Factors; Time Factors; Vitamin B 12 | 2014 |
Domain specific changes in cognition at high altitude and its correlation with hyperhomocysteinemia.
Topics: Acclimatization; Adult; Altitude; Cognition; Cognitive Dysfunction; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Longitudinal Studies; Male; Neuropsychological Tests; Vitamin B 12 | 2014 |
Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study.
Topics: Aged; Diuretics; Female; Folic Acid; Health Services for the Aged; Homocysteine; Humans; Male; Metformin; Netherlands; Osteoporosis; Population Surveillance; Vitamin B 12; Vitamin B 12 Deficiency | 2014 |
Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD.
Topics: Adult; Antioxidants; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Oxidants; Oxidative Stress; Vitamin B 12 | 2017 |
Vitamin status as a determinant of serum homocysteine concentration in type 2 diabetic retinopathy.
Topics: Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Odds Ratio; Prevalence; Regression Analysis; Risk Factors; Vitamin B 12; Vitamins | 2014 |
Homocysteine levels and bad obstetric outcome among female operating room personnel occupationally exposed to nitrous oxide.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Nitrous Oxide; Occupational Exposure; Operating Room Technicians; Pregnancy; Pregnancy Outcome; Reproductive History; Vitamin B 12 | 2014 |
Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis.
Topics: Adult; Biomarkers; Birth Weight; Cohort Studies; Female; Fetal Development; Folic Acid; Genotype; Gestational Age; Homocysteine; Humans; India; Mendelian Randomization Analysis; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Prenatal Exposure Delayed Effects; Vitamin B 12 | 2014 |
Early markers of occult megaloblastosis for low-cost detection of hyperhomocysteinemia in patients with ischaemic stroke: preventive approach for primary health care.
Topics: Anemia, Megaloblastic; Biomarkers; Brain Ischemia; Early Diagnosis; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Neutrophils; Primary Health Care; Stroke; Vitamin B 12 | 2014 |
Endothelin-1 levels and biomarkers of oxidative stress in glaucoma patients.
Topics: Adult; Analysis of Variance; Antioxidants; Biomarkers; Blood Pressure; Case-Control Studies; Endothelin-1; Female; Folic Acid; Glaucoma; Homocysteine; Humans; Intraocular Pressure; Male; Middle Aged; Oxidative Stress; Vitamins | 2015 |
Association of Graded Folic Acid Supplementation and Total Plasma Homocysteine Levels With Hematological Toxicity During First-line Treatment of Nonsquamous NSCLC Patients With Pemetrexed-based Chemotherapy.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Interactions; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Retrospective Studies | 2017 |
Homocysteine, cysteine, folate and vitamin B₁₂ status in type 2 diabetic patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Diabetes Mellitus, Type 2; Disease Progression; Female; Folic Acid; Homocysteine; Humans; Male; Renal Insufficiency, Chronic; Vitamin B 12 | 2015 |
The roles of methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms in moyamoya disease patients.
Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Moyamoya Disease; Nitric Oxide; Polymorphism, Single Nucleotide; Republic of Korea; Vitamin B 12; Young Adult | 2014 |
Serum levels of BDNF, folate and homocysteine: in relation to hippocampal volume and psychopathology in drug naïve, first episode schizophrenia.
Topics: Adolescent; Adult; Blood Chemical Analysis; Brain-Derived Neurotrophic Factor; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Hippocampus; Homocysteine; Humans; Image Processing, Computer-Assisted; Immunoassay; Male; Organ Size; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Young Adult | 2014 |
Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys.
Topics: Adult; Aged; Aged, 80 and over; Ascorbic Acid; Carotenoids; Dyssomnias; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Models, Statistical; Nutrition Surveys; Nutritional Status; Sleep; United States; Vitamin A; Vitamin B 12; Vitamin D; Vitamin E | 2014 |
Homocysteine in patients with inflammatory bowel diseases.
Topics: Adult; Aged; Colitis, Ulcerative; Crohn Disease; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Male; Middle Aged; Prospective Studies; Young Adult | 2014 |
Plasma total homocysteine level in association with folate, pyridoxine, and cobalamin status among Iranian primary breast cancer patients.
Topics: Adult; Aged; Biomarkers; Body Mass Index; Breast Neoplasms; Fasting; Female; Folic Acid; Homocysteine; Humans; Iran; Linear Models; Logistic Models; Middle Aged; Multivariate Analysis; Nutrition Assessment; Nutritional Status; Prospective Studies; Pyridoxal Phosphate; Pyridoxine; Surveys and Questionnaires; Vitamin B 12; White People | 2014 |
MTHFR C677T polymorphism affects normotensive diastolic blood pressure independently of blood lipids.
Topics: Adult; Age Factors; Blood Pressure; Body Mass Index; Diastole; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Lipids; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Young Adult | 2015 |
Increase in the risk of ST elevation myocardial infarction is associated with homocysteine level.
Topics: Adult; Biomarkers; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Myocardial Infarction; Risk Assessment; Risk Factors; Vitamin B 12 | 2014 |
Maternal vitamin B12 deficiency detected in expanded newborn screening.
Topics: Carnitine; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Neonatal Screening; Pregnancy; Pregnancy Complications; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2014 |
Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alcohol Drinking; Brain; Case-Control Studies; Child; Cleft Lip; Cleft Palate; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene-Environment Interaction; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Prenatal Exposure Delayed Effects; Replication Protein C; Young Adult | 2015 |
Proteomic analysis identifies cytoskeleton-interacting proteins as major downstream targets of altered folate status in the aorta of adult rat.
Topics: Animals; Aorta; Computational Biology; Cytoskeletal Proteins; Cytoskeleton; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Homocysteine; Male; Proteomics; Rats; Rats, Wistar; Reproducibility of Results | 2014 |
Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Blotting, Western; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Hypertension, Pregnancy-Induced; Immunohistochemistry; Methylenetetrahydrofolate Reductase (NADPH2); Placenta; Pregnancy; RNA, Messenger; Trophoblasts | 2014 |
Nutritional status of the elderly in rural North China: a cross-sectional study.
Topics: Aged; Aged, 80 and over; Body Mass Index; China; Cholesterol; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nutrition Surveys; Nutritional Status; Obesity; Prevalence; Rural Health; Rural Population; Thinness; Vitamin B 12; Vitamin B 12 Deficiency | 2014 |
Effects of second-generation antipsychotics on selected markers of one-carbon metabolism and metabolic syndrome components in first-episode schizophrenia patients.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Body Mass Index; Carbon; Cholesterol; Female; Folic Acid; Homocysteine; Humans; Lipid Metabolism; Male; Metabolic Syndrome; Olanzapine; Risperidone; Schizophrenia; Sex Factors; Triglycerides; Vitamin B 12; Young Adult | 2014 |
The changing of serum vitamin B12 and homocysteine levels after gastrectomy in patients with gastric cancer: do they associate with clinicopathological factors?
Topics: Adult; Aged; Aged, 80 and over; Female; Folic Acid; Gastrectomy; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Stomach Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency | 2015 |
A cross-sectional study to find out the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotype with plasma levels of folate and total homocysteine by daily folate intake in Japanese.
Topics: Aged; Asian People; Cross-Sectional Studies; Diet; Female; Folic Acid; Genotype; Homocysteine; Humans; Japan; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Status; Polymorphism, Genetic | 2014 |
Folate deficiency in rat pups during weaning causes learning and memory deficits.
Topics: Animals; Behavior, Animal; Brain; Cerebellum; Diet; Disease Susceptibility; Female; Folic Acid; Folic Acid Deficiency; Hippocampus; Homocysteine; Lactation; Learning Disabilities; Liver; Male; Maternal Nutritional Physiological Phenomena; Memory Disorders; Memory, Long-Term; Neurons; Rats, Long-Evans; Spatial Learning; Weaning | 2014 |
Plasma homocysteine, B vitamins and bone mineral density in osteoporosis: a possible risk for bone fracture.
Topics: Body Mass Index; Bone Density; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nigeria; Osteoporosis; Osteoporotic Fractures; Risk Factors; Vitamin B 12; Vitamin B 6 | 2014 |
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.
Topics: Angiotensin II; Animals; Binding Sites; CCCTC-Binding Factor; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; DNA Methylation; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Male; Mice, Inbred C57BL; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; S-Adenosylmethionine; Sp1 Transcription Factor; Telomerase; Telomere; Telomere Shortening; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2015 |
A quantile regression approach can reveal the effect of fruit and vegetable consumption on plasma homocysteine levels.
Topics: Adult; Aged; Cross-Sectional Studies; Eating; Female; Folic Acid; Fruit; Homocysteine; Humans; Male; Middle Aged; Vegetables | 2014 |
Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.
Topics: Animals; Apoptosis; Betaine-Homocysteine S-Methyltransferase; Catalase; Chromatography, High Pressure Liquid; Cochlea; Female; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Glutathione Synthase; Hair Cells, Auditory; Hearing Loss; Homocysteine; Hyperhomocysteinemia; In Situ Nick-End Labeling; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Stress; Phospholipid Hydroperoxide Glutathione Peroxidase | 2015 |
Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles.
Topics: Adult; Carbon; Cohort Studies; DNA; DNA Methylation; Epigenesis, Genetic; Female; Fetal Development; Folic Acid; Genotype; Homocysteine; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy | 2014 |
Micronutrient status in female university students: iron, zinc, copper, selenium, vitamin B12 and folate.
Topics: Adolescent; Adult; Anemia, Iron-Deficiency; Australia; Biomarkers; Body Mass Index; Copper; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Iron, Dietary; Methylmalonic Acid; Micronutrients; Prevalence; Selenium; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult; Zinc | 2014 |
Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome.
Topics: Case-Control Studies; Child; Female; Folic Acid; Homocysteine; Humans; Male; Nephrotic Syndrome; Nigeria; Serum Albumin; Vitamin B 12; Vitamin B Complex | 2014 |
Serum homocysteine, vitamin B12, and folate, and the prevalence and incidence of posterior subcapsular cataract.
Topics: Aged; Biomarkers; Cataract; Cross-Sectional Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Incidence; Male; Middle Aged; New South Wales; Population Surveillance; Prevalence; Retrospective Studies; Vitamin B 12 | 2014 |
Anemias due to essential nutrient deficiencies.
Topics: Anemia; Anemia, Iron-Deficiency; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Iron, Dietary; Vitamin B 12; Vitamin B 12 Deficiency | 2015 |
Effects of differences in serum total homocysteine, folate, and vitamin B12 on cognitive impairment in stroke patients.
Topics: Adult; Aged; Brain; Case-Control Studies; Cognition; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Stroke; Vitamin B 12 | 2014 |
Higher homocysteine associated with thinner cortical gray matter in 803 participants from the Alzheimer's Disease Neuroimaging Initiative.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Biomarkers; Female; Folic Acid; Gray Matter; Homocysteine; Humans; Life Style; Magnetic Resonance Imaging; Male; Neuroimaging; Risk Factors; Vitamin B Complex | 2015 |
Impact of folic acid administration in homocysteine levels, inflammation and in atherosclerotic plaque area in apoE deficient mice.
Topics: Animals; Apolipoproteins E; Folic Acid; Homocysteine; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Random Allocation; Single-Blind Method | 2014 |
Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies.
Topics: Adolescent; Adult; Autoantibodies; Biopterins; Child; Female; Folate Receptor 1; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Middle Aged; Schizophrenia; Young Adult | 2014 |
High serum folate might have a potential dual effect on risk of colorectal cancer.
Topics: Adult; Aged; Body Mass Index; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pyridoxal Phosphate; Risk Factors | 2015 |
Effects of zinc deficiency and zinc supplementation on homocysteine levels and related enzyme expression in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltransferase; Body Weight; Diet; Dietary Supplements; Feeding Behavior; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Kidney; Liver; Male; Organ Size; Rats, Sprague-Dawley; RNA, Messenger; Zinc | 2015 |
Folates from metabolically engineered rice: a long-term study in rats.
Topics: Animals; Body Weight; Erythrocytes; Female; Folic Acid; Food, Fortified; Hematocrit; Homocysteine; Longitudinal Studies; Oryza; Plants, Genetically Modified; Rats, Wistar; Vitamin B 12 | 2015 |
Heterozygous carriers of classical homocystinuria tend to have higher fasting serum homocysteine concentrations than non-carriers in the presence of folate deficiency.
Topics: Aged; Cardiovascular Diseases; Case-Control Studies; Cystathionine beta-Synthase; Dietary Supplements; Fasting; Female; Folic Acid; Folic Acid Deficiency; Genotyping Techniques; Heterozygote; Homocysteine; Homocystinuria; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Prevalence; Risk Factors; Taiwan; Vitamin B 12 | 2015 |
Association between intake of B vitamins and cognitive function in elderly Koreans with cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cognition Disorders; Diet; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Republic of Korea; Vitamin B 12; Vitamin B Complex | 2014 |
Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Chromatography, High Pressure Liquid; Cognition Disorders; Confidence Intervals; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Odds Ratio; Psychiatric Status Rating Scales; Retrospective Studies; Surveys and Questionnaires; Vitamin B 12 | 2015 |
Derivation and validation of homocysteine score in u.s. Men and women.
Topics: Adult; Aged; Alcohol Drinking; Biomarkers; Caffeine; Carbon; Diet; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Middle Aged; Smoking; United States; Vitamins | 2015 |
Influence of microelement concentration on the intensity of alcohol withdrawal syndrome.
Topics: Adult; Alcohol Withdrawal Delirium; Calcitriol; Case-Control Studies; Deficiency Diseases; Ferritins; Folic Acid; Homocysteine; Humans; Iron; Magnesium; Male; Micronutrients; Middle Aged; Severity of Illness Index; Transferrin; Tretinoin; Vitamin B 12; Young Adult; Zinc | 2015 |
[Association of serum folic acid and homocysteine levels and 5, 10-methylenetetrahydrofolate reductase gene polymorphism with schizophrenia].
Topics: Alleles; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Schizophrenia | 2014 |
Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B12 and high homocysteine level with oral lichen planus.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Iron; Iron Deficiencies; Lichen Planus, Oral; Male; Middle Aged; Severity of Illness Index; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2015 |
[An association study between gene polymorphism of the key enzyme's folacin metabolism pathway and plasmatic homocysteine levels in fertile woman].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; China; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Single Nucleotide; Risk Factors | 2014 |
Genetic and environmental factors associated with vitamin B12 status in Amazonian children.
Topics: Alleles; Body Mass Index; Body Weight; Brazil; Child; Child, Preschool; Cross-Sectional Studies; Folic Acid; Gene-Environment Interaction; Genotyping Techniques; Growth Disorders; Homocysteine; Humans; Infant; Linear Models; Nutrition Assessment; Nutritional Status; Overweight; Polymorphism, Single Nucleotide; Prevalence; Risk Factors; Socioeconomic Factors; Vitamin A; Vitamin B 12; Vitamin B 12 Deficiency | 2015 |
Age dependent levels of plasma homocysteine and cognitive performance.
Topics: Adolescent; Adult; Aged; Aging; Attention; C-Reactive Protein; Cognition; Depression; Female; Folic Acid; Homocysteine; Humans; India; Interleukin-6; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Surveys and Questionnaires; Vitamin B 12; Young Adult | 2015 |
Plasma folate, vitamin B12, and homocysteine and cancers of the esophagus, stomach, and liver in a Chinese population.
Topics: Adult; Aged; Case-Control Studies; China; Esophageal Neoplasms; Female; Folic Acid; Homocysteine; Humans; Liver Neoplasms; Male; Middle Aged; Odds Ratio; Risk Factors; Stomach Neoplasms; Surveys and Questionnaires; Vitamin B 12 | 2015 |
Serum folate, cobalamin, homocysteine and methylmalonic acid concentrations in pigs with acute, chronic or subclinical Lawsonia intracellularis infection.
Topics: Animals; Asymptomatic Infections; Desulfovibrionaceae Infections; Folic Acid; Homocysteine; Lawsonia Bacteria; Methylmalonic Acid; Swine; Swine Diseases; Vitamin B 12 | 2015 |
The application of a chemical determination of N-homocysteinylation levels in developing mouse embryos: implication for folate responsive birth defects.
Topics: Animals; Congenital Abnormalities; Disease Models, Animal; Embryo, Mammalian; Embryonic Development; Female; Folic Acid; Folic Acid Deficiency; Genotyping Techniques; Homocysteine; Mice; Neural Tube; Neural Tube Defects | 2015 |
Prevalence of hyperhomocysteinaemia and some of its major determinants in Shaanxi Province, China: a cross-sectional study.
Topics: Adult; Aged; Aged, 80 and over; China; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Surveys; Polymorphism, Genetic; Prevalence; Risk Factors; Young Adult | 2015 |
The influence of a whole food vegan diet with Nori algae and wild mushrooms on selected blood parameters.
Topics: Agaricales; Biomarkers; Blood Chemical Analysis; Cholecalciferol; Creatinine; Diet, Vegetarian; Dietary Supplements; Ergocalciferols; Ferritins; Folic Acid; Hemoglobins; Homocysteine; Humans; Meat; Methylmalonic Acid; Nutrition Assessment; Nutritional Status; Porphyra; Prospective Studies; Recommended Dietary Allowances; Thyrotropin; Time Factors; Transcobalamins; Vitamin B 12; Zinc | 2014 |
Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Hippocampus; Homocysteine; Memory; Methionine; Mice; Mice, Inbred C57BL; Models, Animal; Nutritional Requirements; Promoter Regions, Genetic; Receptors, AMPA; Receptors, Glutamate | 2015 |
Plasma homocysteine levels and hematological toxicity in NSCLC patients after the first cycle of pemetrexed under folate supplementation.
Topics: Adult; Aged; Antineoplastic Agents; Blood Platelets; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Leukocytes; Lung Neoplasms; Male; Middle Aged; Pemetrexed | 2015 |
Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points.
Topics: Biomarkers; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Methylmalonic Acid; Transcobalamins; Vitamin B 12 | 2015 |
Association of folate metabolism gene polymorphisms and pulmonary embolism: A case-control study of West-Siberian population.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Alleles; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Probability; Pulmonary Embolism; Siberia | 2015 |
Metabolism and gene polymorphisms of the folate pathway in Brazilian women with history of recurrent abortion.
Topics: Abortion, Habitual; Adolescent; Adult; Brazil; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Polymorphism, Genetic; Signal Transduction; Vitamin B 12; Young Adult | 2015 |
Folate and homocysteine levels and their association with dietary intakes in Iranian patients infected with Helicobacter pylori: a case-control study.
Topics: Case-Control Studies; Diet; Folic Acid; Helicobacter Infections; Helicobacter pylori; Homocysteine; Humans; Iran; Logistic Models; Vitamin B 12 | 2015 |
Formate metabolism in fetal and neonatal sheep.
Topics: Amniotic Fluid; Animals; Animals, Newborn; Female; Fetus; Folic Acid; Formates; Homocysteine; Postpartum Period; Pregnancy; Pregnancy, Animal; Sheep; Vitamin B 12 | 2015 |
Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits.
Topics: Adult; Cross-Sectional Studies; DNA Methylation; DNA Repair; Female; Folic Acid; Homocysteine; Humans; Life Style; Lymphocytes; Male; Middle Aged; Promoter Regions, Genetic; Smoking; Twins, Monozygotic; Vitamin B 12; Young Adult | 2015 |
Homocysteine but not serum amyloid A, vitamin A and E related to increased risk of metabolic syndrome in post-menopausal Thai women.
Topics: Anthropometry; Body Mass Index; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Metabolic Syndrome; Middle Aged; Odds Ratio; Postmenopause; Risk Factors; Serum Amyloid A Protein; Thailand; Vitamin A; Vitamin E | 2014 |
Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.
Topics: Adult; Betaine-Homocysteine S-Methyltransferase; Cardiomyopathy, Hypertrophic; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Female; Folic Acid; Gene Expression; Gene-Environment Interaction; Glutamate-Cysteine Ligase; Glutathione; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Models, Genetic; Obesity; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors | 2015 |
Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white Caucasians living in the UK.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studies; Diet, Vegetarian; Female; Fetal Blood; Folic Acid; Gestational Age; Homocysteine; Humans; Insulin; Insulin Resistance; Maternal Nutritional Physiological Phenomena; Nutritional Status; Pregnancy; Risk Factors; Triglycerides; United Kingdom; Vitamin B 12; White People | 2015 |
Folate, vitamin B12 and Homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Brazil; Carboxypeptidases; Child; Child, Preschool; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant; Lactation; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Pregnancy; Prevalence; Reduced Folate Carrier Protein; Risk Factors; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2015 |
Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies.
Topics: Adult; Aged; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Iron; Iron Deficiencies; Male; Middle Aged; Mouth Diseases; Parietal Cells, Gastric; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency | 2015 |
Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Cross-Sectional Studies; DNA Methylation; Epilepsy; Female; Folic Acid; Heterocyclic Compounds; Homocysteine; Humans; Lamotrigine; Long Interspersed Nucleotide Elements; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Triazines; Valproic Acid; Vitamin B 12; Young Adult | 2015 |
Serum levels of homocysteine, folate and vitamin B12 in patients with vitiligo before and after treatment with narrow band ultraviolet B phototherapy and in a group of controls.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Ultraviolet Therapy; Vitamin B 12; Vitiligo | 2015 |
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Topics: Adult; Biomarkers; Canada; Case-Control Studies; Cross-Sectional Studies; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Genotype; Genotyping Techniques; Health Surveys; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Nutritional Status; Polymorphism, Single Nucleotide; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2015 |
Fitting homocysteine to disease models, as well as adjusting the models to the disease.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Oxidative Stress; Risk Factors; Signal Transduction; Vitamin B 12 | 2015 |
Do all the patients with vitamin B12 deficiency have pernicious anemia?
Topics: Adult; Aged; Aged, 80 and over; Anemia, Pernicious; Autoantibodies; Case-Control Studies; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Iron; Male; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2016 |
Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study.
Topics: Adipose Tissue; Adiposity; Adolescent; Body Mass Index; Cardiovascular System; Cross-Sectional Studies; Europe; Exercise; Exercise Test; Female; Folic Acid; Homocysteine; Humans; Male; Oxygen Consumption; Physical Fitness; Sex Factors; Skinfold Thickness; Vitamin B 12; White People | 2015 |
Effects of folic acid on dyslipidemia and serum homocysteine in a rat model of cholestasis and hepatic fibrosis.
Topics: Animals; Antioxidants; Biomarkers; Cholestasis, Intrahepatic; Cytoprotection; Disease Progression; Dyslipidemias; Folic Acid; Glutathione; Homocysteine; Lipids; Liver; Liver Cirrhosis, Experimental; Male; Rats, Wistar; Time Factors | 2015 |
Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence.
Topics: Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Ascorbic Acid; Case-Control Studies; Colorectal Neoplasms; Diet; Folic Acid; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Middle Aged; Polymorphism, Single Nucleotide; Pteroylpolyglutamic Acids; Risk Factors; Tetrahydrofolates; Vitamins | 2015 |
Cognitive Status According to Homocysteine and B-Group Vitamins in Elderly Adults.
Topics: Aged; Aged, 80 and over; Cognition; Cognition Disorders; Comorbidity; Confidence Intervals; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Italy; Male; Odds Ratio; Prevalence; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Vitamin B 6 Deficiency | 2015 |
MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Non-alcoholic Fatty Liver Disease; Vitamin B 12 | 2015 |
Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study.
Topics: Adult; Alleles; Diet; Down Syndrome; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors | 2015 |
Complex reference values for endocrine and special chemistry biomarkers across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey.
Topics: Adolescent; Adult; Aged; Apolipoprotein A-I; Biomarkers; Blood Chemical Analysis; Canada; Child; Child, Preschool; Clinical Chemistry Tests; Endocrine System; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Male; Middle Aged; Reference Standards; Reference Values; Young Adult | 2015 |
Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans.
Topics: 3' Untranslated Regions; Adenocarcinoma; Aged; Colorectal Neoplasms; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Republic of Korea | 2015 |
A Protein Extract from Chicken Reduces Plasma Homocysteine in Rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Caseins; Chickens; Choline; Cystathionine gamma-Lyase; Cysteine; Dietary Proteins; Folic Acid; Glycine; Homocysteine; Liver; Male; Meat; Methionine; Rats; Rats, Wistar; Riboflavin; RNA, Messenger; Sarcosine; Serine; Vitamin B 12; Vitamin B 6 | 2015 |
Gene polymorphisms as risk factors for predicting the cardiovascular manifestations in Marfan syndrome. Role of folic acid metabolism enzyme gene polymorphisms in Marfan syndrome.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Biomarkers; Case-Control Studies; Chi-Square Distribution; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Heterozygote; Homocysteine; Homozygote; Humans; Logistic Models; Male; Marfan Syndrome; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Up-Regulation; Vitamin B 12; Young Adult | 2015 |
Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals.
Topics: 5' Untranslated Regions; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid Precursor Protein Secretases; Apolipoprotein E4; Aspartic Acid Endopeptidases; Biomarkers; Case-Control Studies; CpG Islands; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Presenilin-1; Promoter Regions, Genetic; Sex Factors; Vitamin B 12 | 2015 |
The effect of subchronic supplementation with folic acid on homocysteine induced seizures.
Topics: Animals; Behavior, Animal; Brain; Brain Waves; Dietary Supplements; Disease Models, Animal; Electroencephalography; Folic Acid; Homocysteine; Male; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Up-Regulation | 2015 |
Altered one-carbon metabolism in posttraumatic stress disorder.
Topics: Adult; Case-Control Studies; Dehydroepiandrosterone; Depression; Female; Folic Acid; Homocysteine; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Middle Aged; Pituitary-Adrenal System; Psychological Trauma; Risk Factors; Stress Disorders, Post-Traumatic; Vitamin B 12; Vitamin B 6 | 2015 |
Association of Vitamin B12 Deficiency with Homozygosity of the TT MTHFR C677T Genotype, Hyperhomocysteinemia, and Endothelial Cell Dysfunction.
Topics: Adult; Cardiovascular Diseases; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Physical Endurance; Polymorphism, Genetic; Prospective Studies; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2015 |
3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.
Topics: 3' Untranslated Regions; Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; DEAD-box RNA Helicases; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Karyopherins; Male; MicroRNAs; Middle Aged; Polymorphism, Single Nucleotide; ran GTP-Binding Protein; Republic of Korea; Ribonuclease III; Risk; RNA, Neoplasm; Tumor Burden | 2015 |
Metagenomic sequencing reveals altered metabolic pathways in the oral microbiota of sailors during a long sea voyage.
Topics: Biodiversity; Folic Acid; Homocysteine; Humans; Metabolic Networks and Pathways; Metagenome; Metagenomics; Microbiota; Mouth; Mouth Mucosa; RNA, Ribosomal, 16S; Vitamin B 12 | 2015 |
Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Biomarkers; Erythrocyte Count; Female; Folic Acid; Homocysteine; Humans; Kidney Function Tests; Male; Methylmalonic Acid; Middle Aged; Prospective Studies; Reference Values; ROC Curve; Sex Factors; Switzerland; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2015 |
Folate therapy improves the stress-to-rest mean LV volume ratio in myocardial perfusion imaging in patients with diabetes.
Topics: Diabetes Mellitus; Female; Folic Acid; Heart Ventricles; Homocysteine; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Organ Size; Rest; Stress, Physiological | 2015 |
Folic acid improves renal function - in what mechanism?
Topics: Endothelium, Vascular; Folic Acid; Homocysteine; Humans | 2015 |
Accurate measurement of the essential micronutrients methionine, homocysteine, vitamins B6, B12, B9 and their metabolites in plasma, brain and maternal milk of mice using LC/MS ion trap analysis.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Male; Mass Spectrometry; Methionine; Mice; Mice, Inbred C57BL; Micronutrients; Milk; Vitamin B 12; Vitamin B 6 | 2015 |
[Global DNA methylation and homocysteine levels are lower in type 1 diabetes patients].
Topics: Adolescent; Adult; Age Factors; Child; Diabetes Mellitus, Type 1; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Homocysteine; Humans; Male; Young Adult | 2015 |
Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre-eclampsia: a longitudinal study.
Topics: Adult; Arginine; Biomarkers; Body Mass Index; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Risk Factors; United Kingdom; Vitamin B Complex; Vitamin B Deficiency | 2015 |
Correlation between MTHFR gene methylation and pre-eclampsia, and its clinical significance.
Topics: Adult; Case-Control Studies; DNA Methylation; Electrophoresis, Agar Gel; Female; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Pre-Eclampsia; Pregnancy; Vitamin B 12 | 2015 |
B-vitamin status and bone mineral density and risk of lumbar osteoporosis in older females in the United States.
Topics: Absorptiometry, Photon; Aged; Biomarkers; Bone Density; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Nutrition Surveys; Nutritional Status; Osteoporosis; Risk Factors; United States; Vitamin B Complex | 2015 |
Long-term treatment for hyperphenylalaninemia and phenylketonuria: a risk for nutritional vitamin B12 deficiency?
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Incidence; Male; Middle Aged; Phenylketonurias; Prospective Studies; Risk; Risk Assessment; Transcobalamins; Vitamin B 12 Deficiency; Young Adult | 2015 |
Buccal Cytome Biomarkers and Their Association with Plasma Folate, Vitamin B12 and Homocysteine in Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Cheek; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12 | 2015 |
Diabetic neuropathy is not associated with homocysteine, folate, vitamin B12 levels, and MTHFR C677T mutation in type 2 diabetic outpatients taking metformin.
Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Folic Acid; Follow-Up Studies; Genotype; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Outpatients; Prognosis; Vitamin B 12 | 2016 |
Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for co-morbidity with cardiovascular disease.
Topics: Adult; Cardiovascular Diseases; Comorbidity; Depressive Disorder, Major; Erythrocytes; Fatty Acids; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Oxidative Stress; Recurrence; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2015 |
Novel relationships between B12, folate and markers of inflammation, oxidative stress and NAD(H) levels, systemically and in the CNS of a healthy human cohort.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Antioxidants; Biomarkers; Central Nervous System; Deoxyguanosine; F2-Isoprostanes; Female; Folic Acid; Homocysteine; Humans; Inflammation; Interleukin-6; Linear Models; Male; Middle Aged; NAD; Oxidative Stress; Vitamin B 12 | 2015 |
[A prospective study on the association of plasma homocysteine level with stroke in hypertensive patients].
Topics: Antihypertensive Agents; Coronary Artery Disease; Coronary Disease; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hypertension; Incidence; Male; Prospective Studies; Socioeconomic Factors; Stroke | 2015 |
The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake.
Topics: Adult; Biomarkers; Cohort Studies; Diet; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Genetic Association Studies; Homocysteine; Humans; Introns; Ireland; Male; Nutritional Status; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Vitamin B 12; Young Adult | 2015 |
High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood.
Topics: Adult; Canada; Dietary Supplements; Energy Intake; Female; Fetal Blood; Folic Acid; Gene Frequency; Genetic Variation; Genotype; Homocysteine; Humans; Logistic Models; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Assessment; Polymorphism, Single Nucleotide; Pregnancy; Prospective Studies; Surveys and Questionnaires; Tetrahydrofolate Dehydrogenase; Young Adult | 2015 |
Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study.
Topics: Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Multiple System Atrophy; Risk Factors; Vitamin B 12 | 2015 |
Assessing the association between homocysteine and cognition: reflections on Bradford Hill, meta-analyses, and causality.
Topics: Cognition; Cognition Disorders; Dementia; Dietary Supplements; Folic Acid; Homocysteine; Humans; Meta-Analysis as Topic; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2015 |
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation.
Topics: Aged; Blood Cells; Calcium; Cross-Sectional Studies; Dietary Supplements; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine; Telomere; Tetrahydrofolates; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin D | 2016 |
Effects of an antioxidant beverage on biomarkers of oxidative stress in Alzheimer's patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Aged, 80 and over; Alanine Transaminase; Alzheimer Disease; Antioxidants; Aspartate Aminotransferases; Beverages; Biomarkers; Body Mass Index; C-Reactive Protein; Case-Control Studies; Deoxyguanosine; Female; Ferritins; Folic Acid; Glutathione Peroxidase; Homocysteine; Humans; Isoprostanes; Lipids; Male; Malus; Oxidative Stress; Plant Extracts; Protein Carbonylation; Superoxide Dismutase; Tea; Vitamin B 12 | 2016 |
Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.
Topics: Animals; Biomarkers; Body Weight; Chromatography, High Pressure Liquid; Cochlea; Dietary Supplements; Evoked Potentials, Auditory, Brain Stem; Fatty Acids, Omega-3; Female; Folic Acid; Hearing Loss; Homocysteine; Inflammation; Mice; Mice, Inbred C57BL; Oxidative Stress; Pressure; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
H-Type hypertension, stroke and diabetes in China: Opportunities for primary prevention.
Topics: China; Diabetes Mellitus, Type 2; Folic Acid; Homocysteine; Humans; Hypertension; Stroke; Vitamin B Complex | 2016 |
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; China; Cross-Sectional Studies; Dyslipidemias; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Expression; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hypertension; Lipoproteins, HDL; Lipoproteins, LDL; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Triglycerides | 2015 |
Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
Topics: Affect; Aged; Aged, 80 and over; Body Mass Index; Cross-Sectional Studies; Energy Intake; Energy Metabolism; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Socioeconomic Factors; Vitamin B 12 | 2015 |
Plasma Folate, Vitamin B12 and Homocysteine Levels in Children with Solid Tumors at Diagnosis; Results from a Pediatric Referral Centre.
Topics: Carcinogenesis; Case-Control Studies; Child, Preschool; Female; Folic Acid; Folic Acid Deficiency; Greece; Homocysteine; Humans; Male; Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency | 2016 |
Effect of multi-nutrient insufficiency on markers of one carbon metabolism in young women: response to a methionine load.
Topics: Adult; Amino Acids; Biomarkers; Body Height; Carbon; Female; Folic Acid; Food; Glutathione; Homocysteine; Humans; India; Malnutrition; Methionine; Ohio; Vitamin B 12; Vitamin B Complex | 2016 |
Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case-control study.
Topics: Adult; Case-Control Studies; Female; Fluorescence Polarization Immunoassay; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Radioimmunoassay; Risk Factors; Tunisia; Vitamins | 2015 |
Evaluation of fatty acids in pregnancy: plasma or erythrocyte membrane?
Topics: Birth Weight; Fatty Acids; Female; Folic Acid; Homocysteine; Humans; Mothers; Pregnancy; Vitamin B 12 | 2015 |
Betaine is as effective as folate at re-synthesizing methionine for protein synthesis during moderate methionine deficiency in piglets.
Topics: Animals; Betaine; Carbon Isotopes; Choline; Cysteine; Diet; Dietary Supplements; Folic Acid; Homocysteine; Methionine; Models, Biological; Oxidation-Reduction; Phenylalanine; Protein Biosynthesis; Swine | 2016 |
Plasma homocysteine, folate and vitamin B12 levels in patients with lung cancer.
Topics: Adult; Aged; Case-Control Studies; Cell Transformation, Neoplastic; Folic Acid; Homocysteine; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Retrospective Studies; Vitamin B 12 | 2015 |
Evaluate the Effect of Valproate Monotherapy on the Serum Homocysteine, Folate and Vitamin B12 Levels in Epileptic Children.
Topics: Adolescent; Age Factors; Anticonvulsants; Case-Control Studies; Child; Child, Preschool; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Risk Factors; Time Factors; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2015 |
High red blood cell folate is associated with an increased risk of death among adults with diabetes, a 15-year follow-up of a national cohort.
Topics: Aged; Cause of Death; Cerebrovascular Disorders; Cohort Studies; Cotinine; Diabetes Mellitus, Type 2; Dietary Supplements; Dose-Response Relationship, Drug; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Nutrition Surveys; Proportional Hazards Models; Risk Factors; Socioeconomic Factors; Vitamin B 12 | 2015 |
The levels of vitamın B12, folate and homocysteine in mothers and their babies with neural tube defects.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Middle Aged; Neural Tube Defects; Pregnancy; Prevalence; Risk Factors; Turkey; Vitamin B 12; Young Adult | 2016 |
B vitamins related to homocysteine metabolism in adults celiac disease patients: a cross-sectional study.
Topics: Adult; Celiac Disease; Cross-Sectional Studies; Diet Records; Diet, Gluten-Free; Female; Folic Acid; Homocysteine; Humans; Male; Nutritional Requirements; Nutritional Status; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2015 |
Effect of the one‑carbon unit cycle on overall DNA methylation in children with Down's syndrome.
Topics: Age Factors; Biomarkers; Carbon; Child; Child, Preschool; DNA Methylation; Down Syndrome; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12 | 2015 |
Association of a miR-34b binding site single nucleotide polymorphism in the 3'-untranslated region of the methylenetetrahydrofolate reductase gene with susceptibility to male infertility.
Topics: 3' Untranslated Regions; Adult; Folic Acid; Genotype; Homocysteine; Humans; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); MicroRNAs; Middle Aged; Polymorphism, Single Nucleotide | 2015 |
Elevated fibrinogen and lowered homocysteine-vitamin determinants and their association with left atrial thrombus in patients with rheumatic mitral stenosis.
Topics: Adult; Biomarkers; Blood Platelets; Cross-Sectional Studies; Female; Fibrinogen; Folic Acid; Heart Atria; Homocysteine; Humans; Male; Middle Aged; Mitral Valve; Mitral Valve Stenosis; Platelet Aggregation; Rheumatic Heart Disease; Thrombosis; Ultrasonography; Vitamin B 12 | 2015 |
Increased homocysteine levels exist in women with preeclampsia from early pregnancy.
Topics: Adult; Diet; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prospective Studies; Vitamin B 12 | 2016 |
Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults.
Topics: Aged; Blood Pressure; Cohort Studies; Demography; Female; Folic Acid; Follow-Up Studies; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Kidney; Male; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic; Risk Factors; Vitamin B 12 | 2015 |
Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status.
Topics: Adolescent; Adult; Aged; Alleles; Cross-Sectional Studies; Fasting; Female; Folic Acid; Folic Acid Deficiency; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Proportional Hazards Models; Spain; Young Adult | 2016 |
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Topics: Animals; Carbon; DNA Damage; DNA Methylation; Folic Acid; Genotype; Glycine N-Methyltransferase; Hep G2 Cells; Homocysteine; Humans; Liver; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Neoplasms; Nucleotides; Nutritional Status; Purines; S-Adenosylmethionine; Uracil | 2015 |
Effect of losartan with folic acid on plasma homocysteine and vascular ultrastructural changes in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Endothelial Cells; Folic Acid; Hematinics; Homocysteine; Hypertension; Losartan; Male; Microscopy, Electron, Transmission; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2015 |
Serum folate levels and fatality among diabetic adults: A 15-y follow-up study of a national cohort.
Topics: Aged; Cardiovascular Diseases; Cotinine; Diabetes Mellitus; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Middle Aged; Neoplasms; Nutrition Surveys; Proportional Hazards Models; Retrospective Studies; Risk Factors; Socioeconomic Factors; Vitamin B 12 | 2016 |
Homocysteine Levels Show Significant Differences among Mediterranean Dietary Quality Index Variables Compared to Folate and Vitamin B(12) Status in Women.
Topics: Adult; Aged; Aged, 80 and over; Diet Records; Diet, Mediterranean; Female; Folic Acid; Homocysteine; Humans; Middle Aged; Vitamin B 12 | 2015 |
Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis.
Topics: Acute Disease; Adult; Chest Pain; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Risk Factors; Tuberculosis, Pulmonary; Vitamin B Complex | 2016 |
Folate and vitamin B-6 status are not associated with homocysteine, oxidative stress and antioxidant capacities in patients with hepatocellular carcinoma.
Topics: Aged; Antioxidants; Carcinoma, Hepatocellular; Female; Folic Acid; Glutathione Peroxidase; Glutathione Transferase; Homocysteine; Humans; Liver Neoplasms; Male; Malondialdehyde; Middle Aged; Nutritional Status; Oxidative Stress; Pyridoxal Phosphate; Superoxide Dismutase; Vitamin B 6 | 2016 |
Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth.
Topics: Adult; Body Height; Body Mass Index; Body Weight; Brain; Child; Child Development; Cognition; Cross-Sectional Studies; Dietary Supplements; Fasting; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Infant; Logistic Models; Male; Maternal Nutritional Physiological Phenomena; Micronutrients; Pregnancy; Prenatal Care; Prenatal Exposure Delayed Effects; Prospective Studies; Socioeconomic Factors; Spain; Vitamin B 12 | 2017 |
Association between leukocyte telomere length and serum carotenoid in US adults.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Body Mass Index; Carotenoids; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Docosahexaenoic Acids; Eicosapentaenoic Acid; Female; Folic Acid; Homocysteine; Humans; Leukocytes; Logistic Models; Male; Middle Aged; Nutrition Surveys; Socioeconomic Factors; Telomere; Young Adult | 2017 |
Effect of physical activity on levels of homocysteine, folate, and vitamin B12 in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Exercise; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Motor Activity; Risk Factors; Vitamin B 12; Young Adult | 2016 |
[Correlation between offspring congenital heart disease and MTHFR 677C/T polymorphism and general status of pregnant women].
Topics: Case-Control Studies; Female; Folic Acid; Gene Frequency; Genotype; Heart Defects, Congenital; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Prevalence | 2015 |
MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.
Topics: Animals; Congenital Abnormalities; Folic Acid; Genomic Instability; Homocysteine; Humans; Immunologic Deficiency Syndromes; Metabolism, Inborn Errors; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Minor Histocompatibility Antigens; Thymidine Monophosphate | 2016 |
Folic Acid and Vitamins D and B12 Correlate With Homocysteine in Chinese Patients With Type-2 Diabetes Mellitus, Hypertension, or Cardiovascular Disease.
Topics: Aged; Aged, 80 and over; Asian People; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Vitamin B 12; Vitamin D | 2016 |
Effects of Multivitamin Supplements on Cognitive Function, Serum Homocysteine Level, and Depression of Korean Older Adults With Mild Cognitive Impairment in Care Facilities.
Topics: Aged; Cognitive Dysfunction; Depression; Dietary Supplements; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Republic of Korea; Residential Facilities; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2016 |
Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects.
Topics: Animals; Autoantibodies; Blood Proteins; Diet; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Gestational Age; Homocysteine; Humans; Mice; Mice, Inbred C57BL; Neural Tube Defects; Pregnancy; Protein Processing, Post-Translational | 2016 |
Embryonic exposures of lithium and homocysteine and folate protection affect lipid metabolism during mouse cardiogenesis and placentation.
Topics: Acyl-CoA Dehydrogenase; Animals; Cadherins; Cardiotonic Agents; Computational Biology; Embryo, Mammalian; Female; Folic Acid; Heart; Homocysteine; Lipid Metabolism; Lithium Chloride; Male; Mice, Inbred C57BL; Myocardium; Placenta; Placentation; Pregnancy; Transcriptome | 2016 |
Homocysteinemia is Associated with a Lower Degree of PBMC LINE-1 Methylation and a Higher Risk of CIN 2C in the U.S. Post-Folic Acid Fortification Era.
Topics: Adult; Body Mass Index; Contraceptives, Oral, Hormonal; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Leukocytes, Mononuclear; Logistic Models; Long Interspersed Nucleotide Elements; Middle Aged; Papillomavirus Infections; Risk Factors; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Young Adult | 2016 |
Does fish oil or folic acid prevent vascular changes in female progeny caused by maternal exposure to fluoxetine?
Topics: Animals; Antidepressive Agents, Second-Generation; Blood Vessels; Female; Fish Oils; Fluoxetine; Folic Acid; Homocysteine; Lactation; Male; Maternal Exposure; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Phenylephrine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Vasoconstrictor Agents | 2016 |
Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women.
Topics: Adult; Canada; Diet; Dietary Supplements; DNA Methylation; Female; Fetal Blood; Fetus; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Prevalence; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex | 2016 |
Metabolic dysregulation in first-episode schizophrenia patients with respect to genetic variation in one-carbon metabolism.
Topics: Adult; Betaine-Homocysteine S-Methyltransferase; Blood Glucose; Carbon; Case-Control Studies; Dyslipidemias; Fasting; Female; Ferredoxin-NADP Reductase; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins, HDL; Male; Metabolic Syndrome; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Minor Histocompatibility Antigens; One-Carbon Group Transferases; Polymorphism, Genetic; Prevalence; Psychotic Disorders; Schizophrenia; Triglycerides; Vitamin B 12; Young Adult | 2016 |
Comparative case-control study of homocysteine, vitamin B
Topics: Adult; Anticonvulsants; Carbamazepine; Cardiovascular Diseases; Case-Control Studies; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Risk Factors; Vitamin B 12 | 2017 |
Association of Vitamin B12, Folate, and Sulfur Amino Acids With Brain Magnetic Resonance Imaging Measures in Older Adults: A Longitudinal Population-Based Study.
Topics: Aged; Alzheimer Disease; Amino Acids, Sulfur; Atrophy; Brain; Female; Folic Acid; Homocysteine; Humans; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Risk Factors; Statistics as Topic; Sweden; Vitamin B 12; White Matter | 2016 |
Plasma Riboflavin and Vitamin B-6, but Not Homocysteine, Folate, or Vitamin B-12, Are Inversely Associated with Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition-Varese Cohort.
Topics: Adult; Body Mass Index; Breast Neoplasms; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Italy; Logistic Models; Middle Aged; Nutritional Status; Premenopause; Prospective Studies; Riboflavin; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6 | 2016 |
Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia.
Topics: Aged; Aryldialkylphosphatase; Case-Control Studies; Dementia; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Interleukin-1beta; Male; Middle Aged; Poland; Polymorphism, Restriction Fragment Length; Tetrahydrofolates; Vitamin B 12 | 2016 |
Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Drug Interactions; Epithelial Cells; Fluorouracil; Folic Acid; Gene Expression Regulation, Neoplastic; HCT116 Cells; Homocysteine; Humans; Male; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Xenograft Model Antitumor Assays | 2016 |
Effects of Folic Acid and Homocysteine on the Morphogenesis of Mouse Cephalic Neural Crest Cells In Vitro.
Topics: Animals; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Folic Acid; Homocysteine; Mice; Mice, Inbred C57BL; Morphogenesis; Neural Crest | 2017 |
Homocysteine, Liver Function Derangement and Brain Atrophy in Alcoholics.
Topics: Alcoholism; Atrophy; Brain; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Liver; Male; Middle Aged; Tomography, X-Ray Computed; Vitamin B 12; Vitamin B 6 | 2016 |
Maternal and Neonatal Markers of the Homocysteine Pathway and Fetal Growth: The Generation R Study.
Topics: Adult; Biomarkers; Birth Weight; Female; Fetal Blood; Fetal Development; Folic Acid; Homocysteine; Humans; Infant, Newborn; Male; Maternal Nutritional Physiological Phenomena; Netherlands; Pregnancy; Pregnancy Proteins; Prenatal Exposure Delayed Effects; Prospective Studies; Vascular Endothelial Growth Factor Receptor-1; Vitamin B 12 | 2016 |
High homocysteine and low folate plasma concentrations are associated with cardiovascular events but not bleeding during warfarin treatment.
Topics: Aged; Cardiovascular Diseases; Female; Folic Acid; Homocysteine; Humans; Male; Warfarin | 2016 |
Plasma-aminothiols status and inverse correlation of total homocysteine with B-vitamins in arsenic exposed population of West Bengal, India.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arsenic; Bangladesh; Calibration; Case-Control Studies; Chromatography, High Pressure Liquid; Creatinine; Cysteine; Dipeptides; Drinking Water; Environmental Exposure; Environmental Health; Female; Folic Acid; Glutathione; Homocysteine; Humans; India; Male; Malnutrition; Middle Aged; Nutritional Status; Socioeconomic Factors; Vitamin B 12; Vitamin B Complex; Young Adult | 2016 |
Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Cross-Sectional Studies; Energy Intake; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Linear Models; Methylmalonic Acid; Nepal; Nutritional Status; Prevalence; Socioeconomic Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2016 |
Artificial Neural Networks Link One-Carbon Metabolism to Gene-Promoter Methylation in Alzheimer's Disease.
Topics: Age Factors; Aged; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Biomarkers; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Networks, Computer; Presenilin-1; Promoter Regions, Genetic; Sex Factors; Vitamin B 12 | 2016 |
Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection.
Topics: Adult; Antiretroviral Therapy, Highly Active; Female; Folic Acid; HIV Infections; Homocysteine; Humans; Male; Middle Aged; Neurofilament Proteins; Neurons; Vitamin B 12 | 2016 |
[Interaction between passive smoking and folic acid supplement during pregnancy on autism spectrum disorder behaviors in children aged 3 years].
Topics: Autism Spectrum Disorder; Child, Preschool; Dietary Supplements; Female; Fetal Development; Folic Acid; Homocysteine; Humans; Infant, Low Birth Weight; Infant, Newborn; Parents; Pregnancy; Pregnancy Complications; Premature Birth; Smoking; Surveys and Questionnaires; Tobacco Smoke Pollution | 2016 |
Multi-Vitamin B Supplementation Reverses Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Choline; Dietary Supplements; Disease Models, Animal; Folic Acid; Glycogen Synthase Kinase 3 beta; Hippocampus; Homocysteine; Hypoxia; Male; Maze Learning; Memory; Memory Disorders; Mice; Phosphorylation; tau Proteins; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2016 |
Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta.
Topics: Adult; Albumins; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Apolipoprotein E4; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Reference Values; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 | 2016 |
Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects.
Topics: Female; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Pregnancy; Prothrombin; Vitamin B 12 | 2016 |
Influence of food groups on plasma total homocysteine for specific MTHFR C677T genotypes in Chinese population.
Topics: Adult; Aged; Asian People; Diet; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Vitamin B 12 | 2017 |
Vitamin B12 status in women of childbearing age in the UK and its relationship with national nutrient intake guidelines: results from two National Diet and Nutrition Surveys.
Topics: Adult; Cross-Sectional Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Malnutrition; Nutrition Policy; Nutrition Surveys; Prevalence; United Kingdom; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2016 |
[Association of Crohn's disease with transcobalamin Ⅱ gene polymorphisms and serum homocysteine, folate and vitamin B12 levels in Chinese patients].
Topics: Alleles; Crohn Disease; Folic Acid; Folic Acid Deficiency; Genotype; Haplotypes; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Mutation; Polymorphism, Genetic; Prevalence; Risk Factors; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2016 |
Impaired homocysteine metabolism in patients with alcoholic liver disease in Taiwan.
Topics: Adult; Case-Control Studies; Folic Acid; Glutathione; Homocysteine; Humans; Liver Diseases, Alcoholic; Male; Taiwan; Thiobarbituric Acid Reactive Substances; Vitamin B 12; Young Adult | 2016 |
Prospective associations of maternal betaine status with offspring weight and body composition at birth: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study.
Topics: Adipose Tissue; Adolescent; Adult; Betaine; Birth Weight; Body Composition; Body Mass Index; Choline; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Infant; Linear Models; Male; Methionine; Middle Aged; Nutritional Status; Prospective Studies; Sensitivity and Specificity; Singapore; Vitamin B 12; Young Adult | 2016 |
Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment.
Topics: Adult; Betaine-Homocysteine S-Methyltransferase; Case-Control Studies; Child; Choline; Choline Dehydrogenase; Down Syndrome; Female; Folic Acid; Genetic Association Studies; Genotype; Homocysteine; Humans; Metabolic Networks and Pathways; Mothers; Odds Ratio; Phosphatidylethanolamine N-Methyltransferase; Polymorphism, Single Nucleotide; Risk Factors | 2017 |
Molecular and cellular effects of vitamin B12 forms on human trophoblast cells in presence of excessive folate.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Chorionic Gonadotropin, beta Subunit, Human; Cobamides; Cytoprotection; Dietary Supplements; Dose-Response Relationship, Drug; ErbB Receptors; Female; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Malondialdehyde; Pregnancy; Protective Agents; Trophoblasts; Tumor Necrosis Factor-alpha; Vitamin B 12 | 2016 |
Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study.
Topics: Adult; Aged; Alanine Transaminase; Asian People; Aspartate Aminotransferases; China; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; gamma-Glutamyltransferase; Genotype; Homocysteine; Humans; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide | 2016 |
Evaluation of Homocysteine, Vitamin B12 and Folic Acid Levels During all the Trimesters in Pregnant and Preeclamptic Womens.
Topics: Case-Control Studies; Female; Fetal Blood; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Pre-Eclampsia; Pregnancy; Pregnancy Trimesters; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2016 |
Serum folate predicts muscle strength: a pilot cross-sectional study of the association between serum vitamin levels and muscle strength and gait measures in patients >65 years old with diabetes mellitus in a primary care setting.
Topics: Accidental Falls; Aged; Cross-Sectional Studies; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Gait; Hand Strength; Homocysteine; Humans; Hyperhomocysteinemia; Male; Muscle Strength; Pilot Projects; Primary Health Care; Risk Factors; Singapore; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin D; Vitamin D Deficiency | 2016 |
Interactions between lifestyle and MTHFR polymorphisms on homocysteine concentrations in young adults belonging to the 1982 Pelotas Birth Cohort.
Topics: Alleles; Brazil; Cohort Studies; Female; Folic Acid; Folic Acid Deficiency; Gene-Environment Interaction; Genotype; Homocysteine; Humans; Life Style; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Sex Factors; Young Adult | 2017 |
Serum Homocysteine, Vitamin B12 and Folic Acid Levels in Patients with Metabolic Syndrome.
Topics: Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Metabolic Syndrome; Middle Aged; Vitamin B 12 | 2016 |
Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs.
Topics: Anti-Bacterial Agents; Bacteria; Drug Resistance, Microbial; Folic Acid; Homocysteine; Methionine; Microbial Sensitivity Tests; Vitamin B 12 | 2016 |
Comparative Assessment of Vitamin-B12, Folic Acid and Homocysteine Levels in Relation to p53 Expression in Megaloblastic Anemia.
Topics: Aged; Aged, 80 and over; Anemia, Megaloblastic; Bone Marrow Examination; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Tumor Suppressor Protein p53; Up-Regulation; Vitamin B 12; Vitamin B 12 Deficiency | 2016 |
Red blood cell distribution width predicts homocysteine levels in adult population without vitamin B
Topics: Adult; Biomarkers; Erythrocyte Indices; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Physical Examination; Platelet Count; Predictive Value of Tests; Vitamin B 12 | 2017 |
Dorsal column myelopathy after intrathecal chemotherapy for leukemia.
Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Electronic Health Records; Female; Folic Acid; Homocysteine; Humans; Injections, Spinal; Leukemia; Magnetic Resonance Imaging; Male; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration | 2017 |
Epigenetics in type 1 diabetes: TNFa gene promoter methylation status in Chilean patients with type 1 diabetes mellitus.
Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Case-Control Studies; Child; Chile; Diabetes Mellitus, Type 1; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Homocysteine; Humans; Male; Nucleic Acid Denaturation; Pediatric Obesity; Promoter Regions, Genetic; Tumor Necrosis Factor-alpha; Young Adult | 2016 |
Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis.
Topics: Adult; Aged; Case-Control Studies; Coronary Artery Disease; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Myocardial Infarction; Odds Ratio; Polymorphism, Single Nucleotide; Vitamin B 12; Vitamin B Complex | 2017 |
Folate, homocysteine and selected vitamins and minerals status in infertile women.
Topics: Adult; Cross-Sectional Studies; Female; Ferritins; Folic Acid; Homocysteine; Humans; Infertility, Female; Iron; Trace Elements; Vitamin A; Vitamin B 12; Vitamin B Complex; Vitamin E | 2017 |
Increased serum level of homocysteine correlates with retinal nerve fiber layer thinning in diabetic retinopathy.
Topics: Adult; Aged; Cross-Sectional Studies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nerve Fibers; Prospective Studies; Retinal Ganglion Cells; Tomography, Optical Coherence; Vitamin B 12 | 2016 |
Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction.
Topics: Adult; China; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Gestational Age; Homocysteine; Humans; Infant, Newborn; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2016 |
Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2017 |
Periconceptional maternal one-carbon biomarkers are associated with embryonic development according to the Carnegie stages.
Topics: Adult; Biomarkers; Cohort Studies; Crown-Rump Length; Embryonic Development; Female; Folic Acid; Homocysteine; Humans; Pregnancy; Prospective Studies; Ultrasonography, Prenatal; Vitamin B 12; Young Adult | 2017 |
Serum high concentrations of homocysteine and low levels of folic acid and vitamin B
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; China; Coronary Artery Disease; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Incidence; Male; Middle Aged; Prevalence; Retrospective Studies; Risk Factors; Severity of Illness Index; Vitamin B 12 | 2017 |
Effects of blood lead and cadmium levels on homocysteine level in plasma.
Topics: Cadmium; China; Cities; Environmental Pollutants; Female; Folic Acid; Homocysteine; Humans; Lead; Male; Smoking | 2017 |
Patterns of Biomarkers in Cord Blood During Pregnancy and Preeclampsia.
Topics: Apoprotein(a); Biomarkers; Female; Fetal Blood; Folic Acid; Heme Oxygenase-1; Homocysteine; Humans; Infant, Newborn; Lipids; Pre-Eclampsia; Pregnancy; Thyroid Hormones; Thyrotropin; Vitamin B 12 | 2017 |
Maternal and Fetal Folate, Vitamin B
Topics: Albuminuria; Child; Child, Preschool; Cohort Studies; Female; Fetal Blood; Folic Acid; Follow-Up Studies; Glomerular Filtration Rate; Homocysteine; Humans; Infant; Infant, Newborn; Kidney Function Tests; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Vitamin B 12 | 2017 |
Role of homocysteine and folic acid on the altered calcium homeostasis of platelets from rats with biliary cirrhosis.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Bile Ducts; Blood Platelets; Calcium; Calcium Signaling; Cholestasis; Disease Models, Animal; Folic Acid; Homocysteine; Ligation; Liver Cirrhosis, Biliary; Male; Platelet Aggregation; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thrombin | 2017 |
Serum Homocysteine, Folate, and Vitamin B12 Levels in Carbamazepine Treated Epileptic Children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12 | 2016 |
The Nephroprotective Effect of Folic Acid-Only a Matter of Homocysteine?
Topics: Folic Acid; Homocysteine | 2017 |
The Nephroprotective Effect of Folic Acid-Only a Matter of Homocysteine?
Topics: Folic Acid; Homocysteine | 2017 |
The Nephroprotective Effect of Folic Acid-Only a Matter of Homocysteine?-Reply.
Topics: Folic Acid; Homocysteine | 2017 |
Regular breakfast consumption is associated with higher blood vitamin status in adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study.
Topics: Adolescent; Ascorbic Acid; Body Composition; Body Mass Index; Body Weight; Breakfast; Child; Cross-Sectional Studies; Diet; Female; Folic Acid; Health Behavior; Healthy Lifestyle; Homocysteine; Humans; Male; Mental Recall; Nutrition Assessment; Nutritional Status; Socioeconomic Factors; Specimen Handling; Surveys and Questionnaires; Transcobalamins; Vitamin B 12; Vitamin D; Vitamins | 2017 |
Impact of genetic polymorphisms in key enzymes of homocysteine metabolism on the pathophysiology of sickle cell anemia.
Topics: Adolescent; Adult; Alleles; Anemia, Sickle Cell; Child; Cystathionine beta-Synthase; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidative Stress; Polymorphism, Genetic; Young Adult | 2017 |
Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Astrocytes; Cell Count; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Female; Folic Acid; Hippocampus; Homocysteine; Liver; Male; Neurogenesis; Neurons; Organ Size; Rats, Wistar; Valproic Acid | 2017 |
That Which Is Bad Can Trigger Good in the Human Body-Homocysteine-Bound hnRNP-E1 as a Molecular Sensor of Physiologic Folate Deficiency.
Topics: Female; Folic Acid; Folic Acid Deficiency; Heterogeneous-Nuclear Ribonucleoproteins; Homocysteine; Human Body; Humans; Pregnancy; Up-Regulation | 2017 |
Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes.
Topics: Adolescent; Adult; Brazil; Cross-Sectional Studies; Cystathionine beta-Synthase; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Linkage Disequilibrium; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Thrombophilia; Thrombosis; Vitamin B 12; Young Adult | 2017 |
Association between hyperhomocysteinemia and stroke with atherosclerosis and small artery occlusion depends on homocysteine metabolism-related vitamin levels in Chinese patients with normal renal function.
Topics: Aged; Aged, 80 and over; Asian People; Case-Control Studies; Cerebrovascular Disorders; China; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intracranial Arteriosclerosis; Kidney; Male; Middle Aged; Retrospective Studies; Stroke; Vitamin B 12 | 2017 |
Folate Deficiency and Gene Polymorphisms of MTHFR, MTR and MTRR Elevate the Hyperhomocysteinemia Risk.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors | 2017 |
mTOR folate sensing links folate availability to trophoblast cell function.
Topics: Cells, Cultured; Female; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Pregnancy; Proton-Coupled Folate Transporter; Trophoblasts | 2017 |
High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus.
Topics: Adult; China; Cohort Studies; Comorbidity; Cross-Sectional Studies; Diabetes, Gestational; Female; Folic Acid; Homocysteine; Humans; India; Malaysia; Male; Nutritional Status; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2018 |
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Diet; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hydroxyurea; Inflammation; Lipoxygenase; Male; Mice, Transgenic; Phenotype; Phosphorylation; Synapses; tau Proteins; Up-Regulation; Vitamin B Complex; Vitamin B Deficiency | 2017 |
Plasma homocysteine levels are associated with macular thickness in type 2 diabetes without diabetic macular edema.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Macula Lutea; Macular Edema; Male; Middle Aged; Regression Analysis; Vitamin B 12 | 2018 |
Effect of B9 and B12 vitamin intake on semen parameters and fertility of men with MTHFR polymorphisms.
Topics: Adult; Azoospermia; Case-Control Studies; Dietary Supplements; Fertility; Folic Acid; Gene Frequency; Heterozygote; Homocysteine; Homozygote; Humans; Iran; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oligospermia; Phenotype; Polymorphism, Genetic; Severity of Illness Index; Vitamin B 12 | 2017 |
Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus.
Topics: Adult; Cardiovascular Diseases; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Lichen Planus; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Risk Factors | 2017 |
Joint effect of maternal plasma homocysteine and prepregnancy obesity on child blood pressure: a prospective birth cohort study.
Topics: Adult; Biomarkers; Blood Pressure; Body Mass Index; Boston; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Male; Mothers; Obesity; Oxidative Stress; Preconception Care; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Risk Factors; Time Factors; Vitamin B 12 | 2017 |
An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B12 in Chinese Patients with Crohn's Disease.
Topics: Adult; Asian People; Case-Control Studies; Crohn Disease; Female; Folic Acid; Genetic Association Studies; Haplotypes; Homocysteine; Humans; Hyperhomocysteinemia; Male; Polymorphism, Single Nucleotide; Risk Factors; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 2017 |
Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder.
Topics: Adolescent; Biomarkers; Child; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales; Vitamin B 12; Vitamin D; Vitamin D Deficiency | 2017 |
Can Nutrition or Inflammation Moderate the Age-Cognition Association Among Older Adults?
Topics: Age Factors; Aged; beta Carotene; Biomarkers; C-Reactive Protein; Cognition; Cognitive Dysfunction; Diet; Female; Ferritins; Fibrinogen; Folic Acid; Homocysteine; Humans; Inflammation; Iron; Male; Middle Aged; Neuropsychological Tests; Nutrition Surveys; Nutritional Status; Vitamins | 2019 |
B vitamins and pollution, an interesting, emerging, yet incomplete picture of folate and the exposome.
Topics: Environmental Pollution; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B Complex | 2017 |
Diagnostic Values of Serum Levels of Homocysteine and Uric Acid for Predicting Vascular Mild Cognitive Impairment in Patients with Cerebral Small Vessel Disease.
Topics: Aged; Case-Control Studies; Cerebral Small Vessel Diseases; Cholesterol; Cognitive Dysfunction; Female; Folic Acid; Homocysteine; Humans; Logistic Models; Male; Middle Aged; ROC Curve; Uric Acid; Vitamin B 12 | 2017 |
The Impact of Supplementation with Folic Acid on Homocysteine Concentration and Selected Lipoprotein Parameters in Patients with Primary Hypertension.
Topics: Administration, Oral; Adult; Apolipoprotein A-I; Apolipoproteins B; Blood Pressure; Body Mass Index; Cholesterol; Dietary Supplements; Dose-Response Relationship, Drug; Essential Hypertension; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Triglycerides; Young Adult | 2017 |
Vitamin B12, folate and homocysteine status in obese and atopic children: a preliminary study.
Topics: Child; Child, Preschool; Folic Acid; Homocysteine; Humans; Hypersensitivity; Pediatric Obesity; Respiratory Tract Infections; Vitamin B 12 | 2018 |
Toxoplasma Gondii Moderates the Association between Multiple Folate-Cycle Factors and Cognitive Function in U.S. Adults.
Topics: Adult; Biomarkers; Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nutrition Surveys; Sample Size; Socioeconomic Factors; Toxoplasma; Toxoplasmosis; Vitamin B 12; Young Adult | 2017 |
B Vitamins and Hip Fracture: Secondary Analyses and Extended Follow-Up of Two Large Randomized Controlled Trials.
Topics: Female; Folic Acid; Follow-Up Studies; Hip Fractures; Homocysteine; Humans; Male; Middle Aged; Proportional Hazards Models; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Vitamin B Complex | 2017 |
Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats.
Topics: Animals; Antioxidants; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Cholesterol, HDL; Diet, High-Fat; Disease Models, Animal; Folic Acid; Homocysteine; Lipid Peroxidation; Male; Oxidative Stress; Plaque, Atherosclerotic; Rats, Wistar; Time Factors | 2017 |
Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cross-Sectional Studies; Diet Surveys; Female; Ferredoxin-NADP Reductase; Folic Acid; Food, Fortified; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Replication Protein C | 2017 |
A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice.
Topics: Anemia, Megaloblastic; Animals; Body Weight; Cimicifuga; Female; Folic Acid; Homocysteine; Kidney; Liver; Methylmalonic Acid; Mice; Plant Extracts; Tetrahydrofolate Dehydrogenase; Vitamin B 12; Vitamin B 12 Deficiency | 2017 |
One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study.
Topics: Aged, 80 and over; Biomarkers; Cognitive Dysfunction; England; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Prospective Studies; Vitamin B 12 | 2017 |
Influence of phenylketonuria's diet on dimethylated arginines and methylation cycle.
Topics: Arginine; Biomarkers; Child; Chromatography, High Pressure Liquid; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Mass Spectrometry; Methylation; Patient Compliance; Phenylketonurias; Severity of Illness Index; Vitamin B 12 | 2017 |
The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations.
Topics: Abortion, Habitual; Adult; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Pregnancy; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2017 |
Plasma Homocysteine and Serum Folate and Vitamin B
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cognitive Dysfunction; Female; Folic Acid; Homocysteine; Humans; Male; Odds Ratio; Psychiatric Status Rating Scales; Risk Factors; Vitamin B 12 | 2017 |
An Inframe Trinucleotide Deletion in MTRR Exon 1 is Associated with the Risk of Spina Bifida.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Amino Acid Sequence; Cells, Cultured; Exons; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Methylation; Models, Molecular; Pregnancy; Pregnancy Complications; Protein Conformation; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Spinal Dysraphism; Young Adult | 2017 |
Folate serum levels in Italian women entering an in vitro fertilization program.
Topics: Adult; Female; Fertilization in Vitro; Folic Acid; Homocysteine; Humans; Infertility, Female; Vitamin B 12 | 2017 |
Relevance of plasma levels of free homocysteine and methionine as risk predictors for ischemic stroke in the young.
Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Odds Ratio; Risk Factors; Stroke; Vitamin B 12; Vitamin B 6; Young Adult | 2018 |
Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity.
Topics: Adult; Body Mass Index; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; Male; Metabolic Syndrome; Methylmalonic Acid; Middle Aged; Obesity, Morbid; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
Blood lead, cadmium and mercury in relation to homocysteine and C-reactive protein in women of reproductive age: a panel study.
Topics: Adolescent; Adult; C-Reactive Protein; Cadmium; Diet; Female; Folic Acid; Homocysteine; Humans; Lead; Linear Models; Mercury; Metals, Heavy; New York; Prospective Studies; Vitamin B 12; Vitamin B 6; Young Adult | 2017 |
Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Phenytoin; Vitamin B 12 | 2017 |
Relationship between Total Homocysteine, Folic Acid, and Thyroid Hormones in Hypothyroid Dogs.
Topics: Animals; Case-Control Studies; Dog Diseases; Dogs; Female; Folic Acid; Homocysteine; Hypothyroidism; Male; Thyroid Hormones; Thyroxine; Triiodothyronine | 2017 |
Abnormal Biomarkers of Homocysteine Metabolism in Neonates with Conotruncal Heart Defects.
Topics: Biomarkers; Female; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Male; Metabolic Networks and Pathways | 2017 |
Folate, homocysteine and the ovarian cycle among healthy regularly menstruating women.
Topics: Adolescent; Adult; Body Mass Index; Estradiol; Female; Folic Acid; Follicle Stimulating Hormone; Homocysteine; Humans; Luteinizing Hormone; Menstrual Cycle; Progesterone; Testosterone; Women's Health; Young Adult | 2017 |
Folate, vitamin B12, homocysteine and polymorphisms in folate metabolizing genes in children with congenital heart disease and their mothers.
Topics: Adult; Case-Control Studies; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Heart Defects, Congenital; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Single Nucleotide; Risk Factors; Socioeconomic Factors; Vitamin B 12; Young Adult | 2017 |
The Association of Thyroid Function With Maternal and Neonatal Homocysteine Concentrations.
Topics: Adult; Birth Weight; Cohort Studies; Dietary Supplements; Female; Fetal Blood; Folic Acid; Genetic Variation; Homocysteine; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Prospective Studies; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Vitamin B 12; Vitamins | 2017 |
Hyperhomocysteinemia as a Risk Factor for Saccular Intracranial Aneurysm: A Cohort Study in a Chinese Han Population.
Topics: Adult; Aged; Asian People; Biomarkers; Case-Control Studies; Chi-Square Distribution; China; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Intracranial Aneurysm; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Prospective Studies; Protective Factors; Risk Factors; Up-Regulation; Vitamin B 12 | 2017 |
Interplay between 3'-UTR polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk of ischemic stroke.
Topics: 3' Untranslated Regions; Aged; Brain Ischemia; Case-Control Studies; Female; Folic Acid; Gene Expression; Gene-Environment Interaction; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Risk Factors; Stroke | 2017 |
[Association of transcobalamine II gene polymorphisms and serum homocysteine, vitamin B
Topics: Adult; Colitis, Ulcerative; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Transcobalamins; Vitamin B 12 | 2017 |
Homocysteine concentrations in the cognitive progression of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition; Disease Progression; Female; Folic Acid; Geriatric Assessment; Homocysteine; Humans; Hyperhomocysteinemia; Longitudinal Studies; Male; Mental Status and Dementia Tests; Neuropsychological Tests; Nutrition Assessment; Nutritional Status; Surveys and Questionnaires; Time Factors; Up-Regulation; Vitamin B 12 | 2017 |
Vitamin Status and the Development of Postoperative Cognitive Decline in Elderly Surgical Oncologic Patients.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cognitive Dysfunction; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Neoplasms; Preoperative Period; Vitamin B 12 | 2018 |
Vitamin B-6, Independent of Homocysteine, Is a Significant Factor in Relation to Inflammatory Responses for Chronic Kidney Disease and Hemodialysis Patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Female; Folic Acid; Homocysteine; Humans; Inflammation; Male; Middle Aged; Pyridoxal Phosphate; Renal Dialysis; Renal Insufficiency, Chronic; Vitamin B 6; Vitamin B 6 Deficiency | 2017 |
Correlation of Maternal Serum Homocysteine in the First Trimester with the Development of Gestational Hypertension and Preeclampsia.
Topics: Adult; Biomarkers; Blood Pressure; Body Mass Index; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Hypertension, Pregnancy-Induced; Logistic Models; Odds Ratio; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Retrospective Studies; Risk Assessment; Risk Factors; Vitamin B 12 | 2017 |
Folate: a possible role in erectile dysfunction?
Topics: Adult; Case-Control Studies; Erectile Dysfunction; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Risk Factors; Severity of Illness Index; Surveys and Questionnaires; Ultrasonography; Vitamin B 12 | 2018 |
Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging.
Topics: Aged; Aged, 80 and over; Aging; Baltimore; Female; Folic Acid; Gait; Homocysteine; Humans; Linear Models; Longitudinal Studies; Male; Middle Aged; Vitamin B 12; Walking Speed | 2017 |
Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Folic Acid; Gene Expression Regulation; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans | 2018 |
Homocysteine pathway and in vitro fertilization outcome.
Topics: Adolescent; Adult; Erythrocytes; Female; Fertilization in Vitro; Folic Acid; Homocysteine; Humans; Pregnancy; Pregnancy Rate; Prospective Studies; Vitamin B 12; Young Adult | 2018 |
Color Doppler imaging of the retrobulbar circulation and plasmatic biomarkers of vascular risk in age-related macular degeneration: A pilot study.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Circulation; C-Reactive Protein; Ciliary Arteries; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Ophthalmic Artery; Orbit; Pilot Projects; Retinal Artery; Severity of Illness Index; Ultrasonography, Doppler, Color; Vitamin B 12; Wet Macular Degeneration | 2018 |
Association between Maternal and Infantile Markers of Cobalamin Status During the First Month Post-Delivery.
Topics: Breast Feeding; Diet; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Infant; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects; Turkey; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
Topics: Adolescent; Anthropometry; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Child; Cross-Sectional Studies; Female; Folic Acid; Glucocorticoids; Homocysteine; Humans; Lipids; Lupus Erythematosus, Systemic; Nutritional Status; Proteomics; Risk Factors; Tumor Necrosis Factor-alpha | 2018 |
Cognitive impairment is associated with elevated serum homocysteine levels among older adults.
Topics: Aged; Causality; Cognitive Dysfunction; Cohort Studies; Comorbidity; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Prevalence; Republic of Korea; Vitamin B 12 | 2019 |
Genetic polymorphisms in folate metabolism as risk for Down syndrome in the southern China.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Asian People; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Young Adult | 2019 |
Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.
Topics: Asian People; Betaine-Homocysteine S-Methyltransferase; Cleft Lip; Cleft Palate; Dimethylglycine Dehydrogenase; Epistasis, Genetic; Folic Acid; Genome-Wide Association Study; Homocysteine; Humans; Linkage Disequilibrium; Metabolic Networks and Pathways; Mitochondrial Proteins; Polymorphism, Single Nucleotide; Risk Factors; White People | 2018 |
Relation of serum levels of homocysteine, vitamin B12 and folate to cognitive functions in multiple sclerosis patients.
Topics: Adult; Brain; Case-Control Studies; Cognition Disorders; Female; Folic Acid; Homocysteine; Humans; Linear Models; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Psychometrics; Statistics, Nonparametric; Vitamin B 12 | 2018 |
Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Attention Deficit Disorder with Hyperactivity; Betaine-Homocysteine S-Methyltransferase; Case-Control Studies; Child; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Variation; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Pilot Projects; Problem Behavior; Replication Protein C; Signal Transduction | 2018 |
Identification of vitamin B12 deficiency in vegetarian Indians.
Topics: Adult; Biomarkers; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Sample Size; Vegetarians; Vitamin B 12; Vitamin B 12 Deficiency; White People | 2018 |
Single Nucleotide Polymorphisms in Key One-Carbon Metabolism Genes and Their Association with Blood Folate and Homocysteine Levels in a Chinese Population in Yunnan.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Carbon; China; Female; Folic Acid; Genotype; Healthy Volunteers; Homocysteine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Young Adult | 2018 |
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease.
Topics: Adult; Agraphia; Apraxias; Corpus Callosum; Female; Folic Acid; Functional Laterality; Homocysteine; Humans; Magnetic Resonance Imaging; Marchiafava-Bignami Disease; Vitamin B 12 | 2018 |
Early pregnancy folate-cobalamin interactions and their effects on cobalamin status and hematologic variables throughout pregnancy.
Topics: Adult; Anemia, Iron-Deficiency; Body Mass Index; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Iron, Dietary; Longitudinal Studies; Methylmalonic Acid; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Prevalence; Socioeconomic Factors; Vitamin B 12 | 2018 |
Elevated Total Homocysteine in All Participants and Plasma Vitamin B12 Concentrations in Women Are Associated With All-Cause and Cardiovascular Mortality in the Very Old: The Newcastle 85+ Study.
Topics: Aged, 80 and over; Aging; Biomarkers; Cardiovascular Diseases; Correlation of Data; Demography; Erythrocytes; Female; Folic Acid; Health Status Disparities; Homocysteine; Humans; Male; Risk Assessment; Risk Factors; Sex Factors; Socioeconomic Factors; United Kingdom; Vitamin B 12 | 2018 |
S100B, Homocysteine, Vitamin B12, Folic Acid, and Procalcitonin Serum Levels in Remitters to Electroconvulsive Therapy: A Pilot Study.
Topics: Adult; Aged; Biomarkers; Calcitonin; Depressive Disorder, Major; Electroconvulsive Therapy; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Pilot Projects; Remission Induction; S100 Calcium Binding Protein beta Subunit; Severity of Illness Index; Treatment Outcome; Vitamin B 12 | 2018 |
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice.
Topics: Animals; Anticonvulsants; Embryonic Development; Fatty Acids, Omega-3; Female; Fetal Diseases; Folic Acid; Homocysteine; Humans; Male; Mice; Mice, Inbred ICR; Pregnancy; Pregnancy Complications; Seizures; Valproic Acid | 2018 |
Oxidative stress and dietary micronutrient deficiencies contribute to overexpression of epigenetically regulated genes by lupus T cells.
Topics: Adult; Aged; Case-Control Studies; CD4-Positive T-Lymphocytes; Choline; Diet; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Female; Flow Cytometry; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Lupus Erythematosus, Systemic; Male; Methionine; Micronutrients; Middle Aged; Oxidative Stress; Peroxynitrous Acid; Riboflavin; T-Lymphocytes; Vitamin B 12; Vitamin B 6; Young Adult; Zinc | 2018 |
Relationship between plasma levels of homocysteine and the related B vitamins in patients with hemodialysis adequacy or inadequacy.
Topics: Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Renal Dialysis; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2018 |
The intervention of enalapril maleate and folic acid tablet on the expressions of the GRP78 and CHOP and vascular remodeling in the vascular smooth muscle cells of H-hypertensive rats with homocysteine.
Topics: Animals; Enalapril; Folic Acid; Gene Expression; Heat-Shock Proteins; Homocysteine; Hypertension; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Transcription Factor CHOP; Vascular Remodeling | 2018 |
Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Seizures; Severity of Illness Index; Treatment Outcome; Valproic Acid; Vitamin B 6; Young Adult | 2018 |
Metabolic distress in lipid & one carbon metabolic pathway through low vitamin B-12: a population based study from North India.
Topics: Adult; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Cross-Sectional Studies; Dyslipidemias; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Middle Aged; Obesity; Triglycerides; Vitamin B 12; Vitamin B 12 Deficiency; Waist Circumference | 2018 |
Significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia in patients with Behcet's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Behcet Syndrome; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Folic Acid Deficiency; Hematinics; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Taiwan; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2018 |
B Vitamins for Stroke Prevention: Interaction of Low Platelet Count and High Plasma Total Homocysteine.
Topics: Folic Acid; Homocysteine; Humans; Platelet Count; Stroke; Vitamin B Complex | 2018 |
One-carbon metabolite ratios as functional B-vitamin markers and in relation to colorectal cancer risk.
Topics: Betaine; Biomarkers, Tumor; Carbon; Case-Control Studies; Colorectal Neoplasms; Creatinine; Cysteine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Riboflavin; Vitamin B 12; Vitamin B Complex | 2019 |
Evaluation of tracer labelled methionine load test in vitamin B-12 deficient adolescent women.
Topics: Administration, Oral; Adolescent; Body Mass Index; Carbon Dioxide; Carbon Isotopes; Dietary Supplements; Fasting; Female; Folic Acid; Homocysteine; Humans; Iron; Methionine; Serologic Tests; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase; Tunisia; Vitamin B 12 | 2018 |
Classical Homocystinuria in a Juvenile Patient.
Topics: Child, Preschool; Chromatography, Ion Exchange; Cystathionine beta-Synthase; Folic Acid; Homocysteine; Homocystinuria; Humans; Male; Pyridoxine; Treatment Outcome; Vitamin B 12 | 2018 |
Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Female; Folic Acid; Glycogen Synthase Kinase 3 beta; Homocysteine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Mutation; Phosphorylation | 2018 |
Maternal and infant vitamin B12 status during infancy predict linear growth at 5 years.
Topics: Adolescent; Adult; Breast Feeding; Child, Preschool; Diet; Female; Folic Acid; Growth; Homocysteine; Humans; Infant; Lactation; Limit of Detection; Male; Methylmalonic Acid; Middle Aged; Nepal; Random Allocation; Vitamin B 12; Young Adult | 2018 |
Effect of Homocysteine on the Differentiation of CD4
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Colon; Cyclooxygenase 2; Disease Models, Animal; Folic Acid; Group IV Phospholipases A2; Homocysteine; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Mucous Membrane; Nuclear Receptor Subfamily 1, Group F, Member 3; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Th17 Cells; Treatment Outcome; Vitamin B Complex | 2018 |
Folate-dependent constructive effect of cirrhosis on hyperhomocysteinemia.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Cirrhosis | 2018 |
A dietary pattern derived using B-vitamins and its relationship with vascular markers over the life course.
Topics: Adult; Carotid Intima-Media Thickness; Cohort Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Middle Aged; Pulse Wave Analysis; United Kingdom; Vitamin B 12; Vitamin B Complex | 2019 |
A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
Topics: Animals; Apoptosis; Astrocytes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Female; Folic Acid; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Homocysteine; Male; Metabolic Diseases; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Neurons; Psychomotor Performance; Recovery of Function; Stroke | 2018 |
Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico.
Topics: Adult; Arsenic; Biomarkers; Cohort Studies; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Infant, Newborn; Male; Methylation; Mexico; Pregnancy; Pregnant Women; Regression Analysis; Vitamin B 12; Young Adult | 2018 |
[Polymorphisms of methylenetetrahydrofolate reductase gene among women of childbearing age from Shiyan area].
Topics: Adult; Age Factors; Alleles; China; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic | 2018 |
Folic acid, dietary habits, and homocysteine levels in relation to neural tube defects: A case-control study in North India.
Topics: Adult; Case-Control Studies; Diet; Diet, Vegetarian; Dietary Supplements; Feeding Behavior; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; India; Infant; Infant Mortality; Middle Aged; Neural Tube Defects; Odds Ratio; Prevalence | 2018 |
Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India.
Topics: Adult; Alleles; Antigens, Surface; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; India; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Tetrahydrofolate Dehydrogenase | 2018 |
Association between increased plasma levels of homocysteine and depression observed in individuals with primary lactose malabsorption.
Topics: Adult; Body Mass Index; Depression; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Lactase; Lactose Intolerance; Male; Middle Aged; Risk Factors; Vitamin B 12 | 2018 |
Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice.
Topics: Animals; Cognition; Cognitive Dysfunction; Diet; Female; Folic Acid; Folic Acid Deficiency; Glucose; Homocysteine; Insulin Resistance; Lipid Metabolism; Mice; Mice, Inbred ICR; Time Factors | 2018 |
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Topics: Animals; Carbon-Nitrogen Ligases; Folic Acid; Histidine; Homocysteine; Humans; Methylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases | 2018 |
Dietary and lifestyle predictors of folate insufficiency in non-supplemented German women.
Topics: Adult; Biomarkers; Diet; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Germany; Homocysteine; Humans; Life Style | 2019 |
Homocysteine and Folate in Inflammatory Bowel Disease: Can Reducing Sulfur Reduce Suffering?
Topics: CD4-Positive T-Lymphocytes; Cell Differentiation; Folic Acid; Homocysteine; Humans; Inflammatory Bowel Diseases; Sulfur; Th17 Cells | 2018 |
Folic Acid-Containing Dietary Supplement Consumption and Risk of Cardiovascular Diseases in Rheumatoid Arthritis Patients: NHANES 1999-2014.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Incidence; Male; Middle Aged; Nutrition Surveys; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; United States; Vitamin B Complex | 2019 |
Vitamin D Supplementation and Nordic Walking Training Decreases Serum Homocysteine and Ferritin in Elderly Women.
Topics: Aged; Aged, 80 and over; Calcium-Regulating Hormones and Agents; Cholecalciferol; Dietary Supplements; Female; Ferritins; Folic Acid; Homocysteine; Humans; Middle Aged; Vitamin B 12; Walking | 2018 |
Development of a Dietary Methyl Donor Food Frequency Questionnaire to Assess Folate and Vitamin B
Topics: Adolescent; Biomarkers; Child; Child, Preschool; CpG Islands; DNA Methylation; DNA, Viral; Epigenesis, Genetic; Erythrocytes; Female; Folic Acid; Hepatitis B virus; Hepatitis B, Chronic; Homocysteine; Humans; Male; Surveys and Questionnaires; Vitamin B 12 | 2018 |
Association of vitamin B12 mediated hyperhomocysteinemia and methylenetetrafolate reductase (C677T) gene polymorphism with cognitive impairment: A population based study from North India.
Topics: Adult; Aged; Cognitive Dysfunction; Comorbidity; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Vitamin B 12 | 2018 |
A case report of branch retinal artery occlusion in a teenager due to hyperhomocysteinaemia; the interplay of genetic and nutritional defects.
Topics: Adolescent; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Malnutrition; Methylenetetrahydrofolate Reductase (NADPH2); Retinal Artery Occlusion; Vision Disorders; Visual Acuity; Visual Field Tests; Visual Fields; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
Folate/Vitamin B Alleviates Hyperhomocysteinemia-Induced Alzheimer-Like Pathologies in Rat Retina.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Rats, Sprague-Dawley; Retina; Retinal Vessels; tau Proteins; Vitamin B 12 | 2019 |
Homocysteine, Pyridoxine, Folate and Vitamin B12 Levels in Children with Attention Deficit Hyperactivity Disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior Rating Scale; Child; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Pyridoxine; Reference Values; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Wechsler Scales | 2018 |
90th Anniversary Commentary: Moderate Folate Depletion Increases Plasma Homocysteine and Decreases Lymphocyte DNA Methylation in Postmenopausal Women.
Topics: DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Homocysteine; Humans; Literature, Modern; Lymphocytes; Male; Nutritional Requirements; Postmenopause; Recommended Dietary Allowances | 2018 |
The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population.
Topics: Adolescent; Adult; Biomarkers; Erythrocytes; Female; Folic Acid; Genome-Wide Association Study; Genotype; Homocysteine; Humans; Ireland; Linkage Disequilibrium; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Polymorphism, Single Nucleotide; Young Adult | 2018 |
Sex differences in hepatic one-carbon metabolism.
Topics: Betaine; Carbon; Choline; Female; Folic Acid; Homocysteine; Humans; Liver; Male; Models, Biological; Sex Characteristics | 2018 |
Fisher discriminant analysis for classification of autism spectrum disorders based on folate-related metabolism markers.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Autism Spectrum Disorder; Biomarkers; Case-Control Studies; Child; Child, Preschool; Discriminant Analysis; Female; Folic Acid; Homocysteine; Humans; Male; Polymorphism, Single Nucleotide; S-Adenosylhomocysteine; Tetrahydrofolates; Transcobalamins; Vitamin B 12 | 2019 |
Postnatal Administration of Homocysteine Induces Cerebellar Damage in Rats: Protective Effect of Folic Acid.
Topics: Animals; Antioxidants; Cerebellar Diseases; Cerebellum; Folic Acid; Homocysteine; Lipid Peroxidation; Male; Motor Cortex; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Random Allocation; Rats, Wistar | 2019 |
Two-carbon folate cycle of commensal Lactobacillus reuteri 6475 gives rise to immunomodulatory ethionine, a source for histone ethylation.
Topics: Amino Acids; Carbon; Cell Proliferation; Cells, Cultured; Culture Media; Ethionine; Folic Acid; Histones; Homocysteine; Humans; Immunomodulation; Limosilactobacillus reuteri; Methionine; Methylation; Microbiota; Probiotics; THP-1 Cells; Tumor Necrosis Factor-alpha | 2019 |
Predictors of serum cobalamin and its association with homocysteine in community-dwelling older adults.
Topics: Age Factors; Aged; Body Composition; Cross-Sectional Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Independent Living; Inflammatory Bowel Diseases; Male; Neoplasms; Sex Factors; Vitamin B 12 | 2019 |
Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.
Topics: Adolescent; Adult; Biomarkers; Case-Control Studies; Colombia; Female; Folic Acid; Homocysteine; Humans; Pre-Eclampsia; Pregnancy; Vitamin B 12; Young Adult | 2018 |
Increased genomic damage and vitamin B status in inflammatory bowel disease patients: A case-control, prospective, pilot study.
Topics: Adult; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; DNA Damage; Female; Folic Acid; Giant Cells; Homocysteine; Humans; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Middle Aged; Pilot Projects; Prospective Studies; Pyridoxine; Vitamin B Complex; Young Adult | 2019 |
[The interrelationship of indices of hemocysteine and genetic polymorphisms conditioning disorders of folates metabolism in healthy population].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Risk Factors | 2017 |
Higher maternal plasma folate, vitamin B
Topics: Adolescent; Adult; Biomarkers; Birth Weight; Blood Pressure; Case-Control Studies; Female; Fetal Blood; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Newborn; Infant, Premature; Nutritional Status; Pre-Eclampsia; Pregnancy; Premature Birth; Up-Regulation; Vitamin B 12; Young Adult | 2019 |
Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach.
Topics: Adolescent; Adult; Cross-Sectional Studies; Diet; Docosahexaenoic Acids; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Middle Aged; Models, Theoretical; Socioeconomic Factors; Surveys and Questionnaires; Vitamin B 12; Young Adult | 2020 |
Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease.
Topics: Animals; Betaine; Carbon; Choline; Diet, High-Fat; Dietary Supplements; DNA Methylation; Folic Acid; Glutathione; Homocysteine; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; S-Adenosylmethionine | 2019 |
B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study.
Topics: Aged; Aging; Biomarkers; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Depression; Female; Folic Acid; Homocysteine; Humans; Ireland; Male; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Pyridoxine; Vitamin B 12; Vitamin B Complex | 2019 |
One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.
Topics: Aged; Biomarkers, Tumor; Carcinoma, Transitional Cell; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Odds Ratio; Prospective Studies; Risk Assessment; Smoking; Urinary Bladder Neoplasms; Vitamin B 12; Vitamin B 6 | 2019 |
Supplementation with dairy matrices impacts on homocysteine levels and gut microbiota composition of hyperhomocysteinemic mice.
Topics: Animals; Diet; Disease Models, Animal; Fermented Foods; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Milk | 2020 |
Is the routine screening for hyperhomocysteinaemia recommended in patients with chronic plaque psoriasis?
Topics: Chronic Disease; Folic Acid; Homocysteine; Humans; Psoriasis; Vitamin B 12 | 2019 |
Reference values of a new serum folate assay traceable to the WHO International Standard.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Chemical Analysis; Folic Acid; Homocysteine; Humans; Middle Aged; Reference Values; Vitamin B 12; World Health Organization; Young Adult | 2019 |
Preconception folate status and reproductive outcomes among a prospective cohort of folate-replete women.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anovulation; Female; Folic Acid; Homocysteine; Humans; Preconception Care; Pregnancy; Prospective Studies; Young Adult | 2019 |
Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid.
Topics: Animals; Behavior, Animal; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Growth and Development; Homocysteine; Methylation; MicroRNAs; Nervous System; Pregnancy; Rats, Wistar; Vitamin B 12 | 2019 |
Relationship between Homocysteine, Folate, Vitamin B
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Hand Strength; Homes for the Aged; Homocysteine; Humans; Hyperhomocysteinemia; Lower Extremity; Male; Muscle Strength; Nutritional Status; Physical Functional Performance; Regression Analysis; Sex Factors; Vitamin B 12 | 2019 |
Serum folate and vitamin B
Topics: Adult; Aged; Atherosclerosis; Cohort Studies; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Incidence; Male; Middle Aged; Republic of Korea; Risk Factors; Surveys and Questionnaires; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2019 |
Homocysteine Metabolism in Children and Adolescents: Influence of Age on Plasma Biomarkers and Correspondent Genotype Interactions.
Topics: Adolescent; Age Factors; Biomarkers; Child; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Methylmalonic Acid; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Vitamin B 12; Vitamin B Complex | 2019 |
Klotho, vitamin D and homocysteine levels during acute episode and remission periods in schizophrenia patients.
Topics: Acute Disease; Adult; Aged; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Glucuronidase; Homocysteine; Humans; Klotho Proteins; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Vitamin B 12; Vitamin D; Young Adult | 2019 |
Co-relation of Cerebral Venous Sinus Thrombosis with Vitamin B12 and Homocysteine Levels in a Tertiary Care Centre.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Sinus Thrombosis, Intracranial; Tertiary Care Centers; Vitamin B 12; Vitamin B 12 Deficiency | 2019 |
Folate/homocysteine metabolism and lung cancer risk among smokers.
Topics: Age Factors; Aged; Female; Folic Acid; Genotype; Homocysteine; Humans; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Poland; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Reproducibility of Results; Risk Factors; Sex Factors; Smoking | 2019 |
Associations among serum folate, waist-to-hip ratio, lipid profile, and eating habits with homocysteine in an elderly Thai population.
Topics: Aged; Cross-Sectional Studies; Feeding Behavior; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Middle Aged; Thailand; Vitamin B 12; Waist-Hip Ratio | 2019 |
Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one-carbon cycle in Wistar rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcium; Cyclooxygenase 2; Cystathionine beta-Synthase; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation; Group II Phospholipases A2; Homocysteine; Humans; Malondialdehyde; Parathyroid Hormone; Phosphates; Placenta; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Thromboxane B2; Vitamin B 12; Vitamin D Deficiency | 2019 |
Associations between folate and choline intake, homocysteine metabolism, and genetic polymorphism of MTHFR, BHMT and PEMT in healthy pregnant Polish women.
Topics: Adolescent; Adult; Betaine-Homocysteine S-Methyltransferase; Choline; Female; Folic Acid; Genotype; Glutathione; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Phosphatidylethanolamine N-Methyltransferase; Poland; Polymorphism, Genetic; Pregnancy; Pregnancy Trimester, Third; Young Adult | 2020 |
The relationship between homocysteine level and vitamins B12, B9 and B6 status in patients with chronic kidney disease.
Topics: Folic Acid; Homocysteine; Humans; Renal Insufficiency, Chronic; Ukraine; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2019 |
Association of homocysteine, folate, and white matter hyperintensities in Parkinson's patients with different motor phenotypes.
Topics: Aged; Female; Folic Acid; Gait Disorders, Neurologic; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Postural Balance; Severity of Illness Index; White Matter | 2019 |
Investigating vitamin B12 deficiency.
Topics: Adult; Aged; Biomarkers; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Infant; Malabsorption Syndromes; Male; Malnutrition; Methylmalonic Acid; Physical Examination; Practice Guidelines as Topic; Pregnancy; Referral and Consultation; Risk Factors; United Kingdom; Vitamin B 12; Vitamin B 12 Deficiency; Vulnerable Populations | 2019 |
Is there a possible relationship between gastric intestinal metaplasia and systemic arterial stiffness?
Topics: Adult; Aged; Chronic Disease; Female; Folic Acid; Gastritis; Gastritis, Atrophic; Homocysteine; Humans; Intestines; Male; Metaplasia; Middle Aged; Pulse Wave Analysis; Stomach; Vascular Stiffness; Vitamin B 12 | 2019 |
Association between homocysteine, vitamin B
Topics: Adult; Aged; China; Cross-Sectional Studies; Erectile Dysfunction; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Surveys and Questionnaires; Vitamin B 12 | 2019 |
Association between polymorphisms of a folate - homocysteine - methionine - SAM metabolising enzyme gene and multiple sclerosis in a Polish population.
Topics: Adult; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Multiple Sclerosis; Poland | 2019 |
The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Autism Spectrum Disorder; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cystathionine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Male; Mass Spectrometry; Methionine; Methylation; Mutation; Oxidation-Reduction; Phenotype; Vitamin B 12; Vitamin B 6 | 2019 |
Association Between Cognitive Impairment and Vitamin B12, Folate, and Homocysteine Status in Elderly Adults: A Retrospective Study.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognitive Dysfunction; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 2019 |
Homocysteine Serum Levels as Prognostic Marker of Hepatocellular Carcinoma with Portal Vein Thrombosis.
Topics: Adult; Aged; Biomarkers, Tumor; Budd-Chiari Syndrome; Carcinoma, Hepatocellular; Cholesterol, LDL; Female; Folic Acid; Homocysteine; Humans; Liver Neoplasms; Male; Middle Aged; Portal Vein; Prognosis; Vitamin B 12; Vitamin B 6 | 2019 |
Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion.
Topics: Abortion, Spontaneous; Adult; Alleles; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy | 2019 |
Important Metabolites in Maintaining Folate Cycle, Homocysteine, and Polyamine Metabolism Associated with Ranibizumab Treatment in Cultured Human Tenon's Fibroblasts.
Topics: Adolescent; Adult; Aged; Cells, Cultured; Female; Fibroblasts; Folic Acid; Homocysteine; Humans; Male; Metabolomics; Middle Aged; Polyamines; Ranibizumab; Tendons; Young Adult | 2019 |
Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: a case-control study.
Topics: Adult; Case-Control Studies; Dietary Supplements; Folic Acid; Homocysteine; Humans; Impotence, Vasculogenic; Male; Middle Aged; Penis; Vitamin B Complex | 2020 |
Association of MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms with Neural Tube Defects in Tunisian Parents.
Topics: Alleles; Fathers; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Homocystinuria; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Muscle Spasticity; Neural Tube Defects; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Psychotic Disorders; Tunisia | 2019 |
Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients with or without microcytosis.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Erythropoiesis; Female; Folic Acid; Folic Acid Deficiency; Glossitis; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Iron Deficiencies; Male; Middle Aged; Parietal Cells, Gastric; Tongue; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2019 |
Maternal and cord blood homocysteine, vitamin B12, folate, and B-type natriuretic peptide levels at term for predicting congenital heart disease of the neonate: A case-control study.
Topics: Case-Control Studies; Female; Fetal Blood; Folic Acid; Heart Defects, Congenital; Homocysteine; Humans; Infant, Newborn; Natriuretic Peptide, Brain; Pregnancy; Vitamin B 12 | 2020 |
Does serum gastric parietal cell antibody titer have influence on anemia and vitamin B12 deficiency in atrophic glossitis patients?
Topics: Adult; Aged; Aged, 80 and over; Anemia, Macrocytic; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Tongue; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with macrocytosis.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Anemia, Macrocytic; Atrophy; Autoantibodies; Case-Control Studies; Erythrocyte Indices; Female; Folic Acid; Glossitis; Hematinics; Hematologic Diseases; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Tongue; Vitamin B 12; Young Adult | 2019 |
Association of Serum Homocysteine, Vitamin B12 and Folic Acid Levels with Metabolic Syndrome.
Topics: Folic Acid; Homocysteine; Humans; Metabolic Syndrome; Vitamin B 12 | 2018 |
Effect of Folic Acid on Cisplatin-Induced Ototoxicity: A Functional and Morphological Study.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cochlea; Drug Administration Schedule; Evoked Potentials, Auditory; Evoked Potentials, Auditory, Brain Stem; Folic Acid; Hair Cells, Auditory; Hearing Loss; Homocysteine; Male; Microscopy, Electron; Organ of Corti; Ototoxicity; Rats, Wistar; Sensory Thresholds; Vitamin B Complex | 2019 |
Hyperhomocysteinemia is key for increased susceptibility to PND in aged mice.
Topics: Animals; Cognition; Dietary Supplements; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mice; Postoperative Cognitive Complications; Postoperative Period; Preoperative Period; Risk Factors; S-Adenosylmethionine; Vitamin B 12 | 2019 |
A novel approach in the management of hyperhomocysteinemia.
Topics: Alcohol Oxidoreductases; Animals; Choline; Cytidine Diphosphate Choline; Dietary Supplements; Endothelial Cells; Folic Acid; Homocysteine; Humans; Hydrolysis; Hyperhomocysteinemia; Kidney; Life Style; Liver; Methionine; Models, Theoretical; Vitamin B 12; Vitamin B 6 | 2019 |
Relationship between folate, vitamin B
Topics: Aged; Case-Control Studies; China; Cognitive Dysfunction; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Risk Factors; Transaminases; Vitamin B 12 | 2020 |
Association of Leukocyte Telomere Length with Mild Cognitive Impairment and Alzheimer's Disease: Role of Folate and Homocysteine.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cognitive Dysfunction; Correlation of Data; Female; Folic Acid; Homocysteine; Humans; Leukocytes; Male; Middle Aged; Telomere Shortening | 2019 |
Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats.
Topics: Animals; Cell Count; Corticosterone; Diet; Dose-Response Relationship, Drug; Doublecortin Protein; Female; Fluorescent Antibody Technique; Folic Acid; Hippocampus; Homocysteine; Neurogenesis; Random Allocation; Rats; Sulfathiazoles; Tetrahydrofolates; Time Factors | 2019 |
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antidotes; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Infant; Leucovorin; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12 | 2019 |
[Folic acid relieves rat cardiomyocyte injury induced by homocystein through DNA methylation].
Topics: Animals; Apoptosis; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Folic Acid; Homocysteine; Myocytes, Cardiac; Rats | 2019 |
Blood concentrations of vitamins B1, B6, B12, C and D and folate in palliative care patients: Results of a cross-sectional study.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Palliative Care; Thiamine; Vitamin B 12; Vitamin B 6 | 2019 |
Serum total homocysteine level in Iraqi woman with unexplained recurrent Miscarriage.
Topics: Abortion, Habitual; Adult; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; ROC Curve; Sensitivity and Specificity; Vitamin B 12 | 2019 |
A Cross-Sectional Study of Serum Folate and Vitamin B12 Levels in Psychiatric Inpatients.
Topics: Adult; Comorbidity; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; India; Inpatients; Male; Mental Disorders; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 2019 |
Prenatal folate, homocysteine and vitamin B
Topics: Brain; Child; Child Behavior Disorders; Cognition Disorders; Cohort Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Language Development Disorders; Magnetic Resonance Imaging; Male; Netherlands; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 2019 |
Hyperhomocysteinemia induced locked-in syndrome in a young adult due to folic acid deficiency.
Topics: Adolescent; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Locked-In Syndrome; Male; Vitamin B 12; Young Adult | 2021 |
Comment on 'The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B12 levels in patients with acne': may retinoids be useful to treat hyperhomocysteinemia found in patients affected by hidradenitis suppurativa?
Topics: Acne Vulgaris; Folic Acid; Hidradenitis Suppurativa; Homocysteine; Humans; Hyperhomocysteinemia; Isotretinoin; Retinoids; Vitamin B 12 | 2020 |
Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh.
Topics: Bangladesh; Biomarkers; Birth Weight; Body Mass Index; Female; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Newborn; Male; Maternal Health; Nutritional Status; Pregnancy; Pregnancy Complications, Hematologic; Prognosis; Prospective Studies; Young Adult | 2019 |
Folic Acid Protects Rat Cerebellum Against Oxidative Damage Caused by Homocysteine: the Expression of Bcl-2, Bax, and Caspase-3 Apoptotic Genes.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Cerebellum; Female; Folic Acid; Homocysteine; Male; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar | 2020 |
Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes.
Topics: Age Factors; Aged; Alcohol Drinking; Anemia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Odds Ratio; Republic of Korea; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2019 |
Interictal epileptiform discharges on electroencephalography in children with methylenetetrahydrofolate reductase (MTHFR) polymorphisms.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Vitamin B 12 | 2020 |
Blood homocysteine and folic acid levels may provide reference value for the treatment of sudden total frequency deafness.
Topics: Adult; Deafness; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Reference Values; Treatment Outcome | 2019 |
The relationship between cognitive impairment and homocysteine in a B12 and folate deficient population in China: A cross-sectional study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; China; Cognitive Dysfunction; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 2019 |
A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Carcinoma, Non-Small-Cell Lung; Depression; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lung Neoplasms; Male; Mesothelioma; Mesothelioma, Malignant; Middle Aged; Pemetrexed; Prospective Studies; Treatment Outcome; Vitamin B 12; Vitamins | 2019 |
Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs.
Topics: Animals; Brain; Carrier Proteins; Diet; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Fetal Growth Retardation; Fetus; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation, Developmental; Homocysteine; Kidney; Liver; Male; Maternal Exposure; Mice; Mice, Inbred C57BL; MicroRNAs; Paternal Exposure; Placenta; Pregnancy; Pregnancy Complications; Reverse Transcriptase Polymerase Chain Reaction; Vitamin B 12; Vitamin B 12 Deficiency | 2019 |
Reduced serum concentrations of vitamin B
Topics: Adult; Cross-Sectional Studies; Diabetes, Gestational; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Pregnancy; Pregnancy Trimester, First; Saudi Arabia; Thyrotropin; Vitamin B 12; Vitamins | 2019 |
Trends of folate, vitamin B
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; India; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Vitamin B 12; Vitamin B Complex; Young Adult | 2020 |
Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Biogenic Monoamines; Brain; Citalopram; Depression; Disease Models, Animal; Folic Acid; Homocysteine; Male; Rats, Sprague-Dawley; Stress, Psychological | 2020 |
A Clinical study to determine levels of vitamin B12,Folic acid and Homocysteine in patients of Ischemic stroke.
Topics: Brain Ischemia; Folic Acid; Homocysteine; Humans; Ischemic Stroke; Stroke; Vitamin B 12 | 2020 |
Plasma homocysteine levels in patients with keratoconus.
Topics: Folic Acid; Homocysteine; Humans; Keratoconus; Prospective Studies; Vitamin B 12 | 2020 |
The relationship between dietary patterns and depression mediated by serum levels of Folate and vitamin B12.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Depression; Depressive Disorder, Major; Female; Folic Acid; Homocysteine; Humans; Iran; Logistic Models; Male; Middle Aged; Tryptophan; Vitamin B 12; Young Adult | 2020 |
Elevated cerebrospinal fluid homocysteine is associated with blood-brain barrier disruption in amyotrophic lateral sclerosis patients.
Topics: Amyotrophic Lateral Sclerosis; Blood-Brain Barrier; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2020 |
Association of Serum Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Causality; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Proportional Hazards Models; Risk Assessment; United States | 2020 |
Environmental UVR Levels and Skin Pigmentation Gene Variants Associated with Folate and Homocysteine Levels in an Elderly Cohort.
Topics: Aged; Australia; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Skin; Skin Pigmentation; Ultraviolet Rays | 2020 |
Assessment of folate and cobalamin concentrations in relation to their dependent intracellular metabolites in serum of pigs between 6 and 26 weeks of age.
Topics: Animals; Cytoplasm; Folic Acid; Homocysteine; Methylmalonic Acid; Serum; Sus scrofa; Vitamin B 12 | 2020 |
Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study.
Topics: Adult; Case-Control Studies; China; Female; Folic Acid; Homocysteine; Humans; Infant, Low Birth Weight; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Premature Birth; Retrospective Studies; Risk Factors; Vitamin B 12 | 2020 |
The determinants of maternal homocysteine in pregnancy: findings from the Ottawa and Kingston Birth Cohort.
Topics: Canada; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy | 2020 |
Induced DNA hypomethylation by Folic Acid Deprivation in Bovine Fibroblast Donor Cells Improves Reprogramming of Somatic Cell Nuclear Transfer Embryos.
Topics: Animals; Cattle; Cells, Cultured; DNA Methylation; Embryo, Mammalian; Female; Fibroblasts; Folic Acid; Gene Expression; Homocysteine; Methionine; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Promoter Regions, Genetic | 2020 |
Maternal B12, Folate and Homocysteine Concentrations and Offspring Cortisol and Cardiovascular Responses to Stress.
Topics: Adolescent; Adult; Cardiovascular System; Female; Folic Acid; Homocysteine; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Stress, Psychological; Vitamin B 12; Young Adult | 2020 |
Comparison of Vitamin B12, Vitamin D, and Folic Acid Blood Levels in Plumbism Patients and Controls in Eastern Iran.
Topics: Case-Control Studies; Folic Acid; Homocysteine; Humans; Iran; Lead Poisoning; Vitamin B 12; Vitamin D; Vitamins | 2021 |
Relationship between cobalt transporter II gene rs9606756 site mutant and serum homocysteine level and recurrent cerebral infarction in young and middle-aged people.
Topics: Adult; Age Factors; Alleles; Cerebral Infarction; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Middle Aged; Point Mutation; Polymorphism, Genetic; Recurrence; Transcobalamins; Vitamin B 12 | 2021 |
[Correlation of the levels of seminal plasma homocysteine, folate and cobalamin with semen parameters in obese men].
Topics: Folic Acid; Homocysteine; Humans; Infertility, Male; Male; Obesity; Semen; Semen Analysis; Sperm Count; Sperm Motility; Spermatozoa; Vitamin B 12 | 2018 |
The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents.
Topics: Adolescent; Child; Depressive Disorder; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Severity of Illness Index; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin D | 2020 |
Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Creatine; Folic Acid; Homocysteine; Humans; Intravital Microscopy; Microcirculation; Middle Aged; Pyridoxal Phosphate; Severity of Illness Index; Thrombotic Microangiopathies; Vitamin B 12 | 2020 |
Identifying gene-environment interactions on the efficacy of folic acid therapy for hyperhomocysteinemia based on prediction model.
Topics: Aged; Algorithms; Coronary Disease; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Logistic Models; Machine Learning; Male; Middle Aged; Models, Theoretical; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; Stroke; Treatment Failure; Treatment Outcome | 2020 |
Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis.
Topics: Arthritis, Rheumatoid; Folic Acid; Homocysteine; Humans; Methotrexate; Spondylitis, Ankylosing | 2020 |
Homocysteine, but not MTHFR gene polymorphism, influences depressive symptoms in patients with schizophrenia.
Topics: Depression; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Schizophrenia | 2020 |
Homocysteine induces melanocytes apoptosis via PERK-eIF2α-CHOP pathway in vitiligo.
Topics: Adult; Apoptosis; Case-Control Studies; Cell Proliferation; Disease Progression; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Female; Folic Acid; Homocysteine; Humans; Male; Melanins; Melanocytes; Models, Biological; Signal Transduction; Transcription Factor CHOP; Vitiligo | 2020 |
Genetic and environmental factors associated with homocysteine concentrations in a population of healthy young adults. Analysis of the MAGNETIC study.
Topics: Adolescent; Adult; Age Factors; Biomarkers; Creatinine; Diet, Healthy; Feeding Behavior; Female; Folic Acid; Gene-Environment Interaction; Healthy Volunteers; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Young Adult | 2020 |
Association between gene promoter methylation of the one-carbon metabolism pathway and serum folate among patients with hyperhomocysteinemia.
Topics: Carbon; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylation; Promoter Regions, Genetic | 2020 |
Low doses of folic acid can reduce hyperhomocysteinemia-induced glomerular injury in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Drug Evaluation, Preclinical; Folic Acid; Homocysteine; Hyperhomocysteinemia; Hypertension; Kidney Cortex; Kidney Diseases; Male; Malondialdehyde; Membrane Proteins; NADPH Oxidase 2; NADPH Oxidase 4; Podocytes; Random Allocation; Rats, Inbred SHR; Superoxide Dismutase; Vitamin B Complex | 2020 |
Association between serum folate levels and schizophrenia based on sex.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Japan; Male; Middle Aged; Schizophrenia; Sex Factors; Vitamin B 6 | 2020 |
Methylene Tetrahydrofolate Reductase Deficiency.
Topics: Folic Acid; Homocysteine; Homocystinuria; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Psychotic Disorders | 2020 |
Effects of MTHFR C677T polymorphism on vitamin D, homocysteine and natural killer cell cytotoxicity in women with recurrent pregnancy losses.
Topics: Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Killer Cells, Natural; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Retrospective Studies; Vitamin B 12; Vitamin D; Vitamins | 2020 |
Functional vitamin B12 deficiency in phenylketonuria patients and healthy controls: An evaluation with combined indicator of vitamin B12 status as a biochemical index.
Topics: Adolescent; Biomarkers; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Phenylketonurias; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Distribution characteristics of circulating homocysteine and folate and related factors in agriculture, stock-raising and urban populations: a cross-sectional survey.
Topics: Agriculture; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B 12 | 2021 |
Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women.
Topics: Adult; Asian People; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Japan; Longitudinal Studies; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnant Women; Prospective Studies; Tetrahydrofolates; Young Adult | 2020 |
Hyperhomocysteinemia is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density.
Topics: Bone Density; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Osteitis; Osteoporosis, Postmenopausal; Oxidoreductases; Polymorphism, Genetic; Postmenopause; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3.
Topics: Carrier Proteins; Cohort Studies; Dietary Supplements; Female; Folic Acid; HEK293 Cells; Homocysteine; Humans; Male; Middle Aged; Neurotoxicity Syndromes | 2020 |
Screening of folate-producing lactic acid bacteria and modulatory effects of folate-biofortified yogurt on gut dysbacteriosis of folate-deficient rats.
Topics: Animals; DNA, Bacterial; Dysbiosis; Fermentation; Folic Acid; Folic Acid Deficiency; Food, Fortified; Gastrointestinal Microbiome; Homocysteine; Lactobacillales; Lactobacillus plantarum; Male; Rats; Rats, Sprague-Dawley; Sequence Analysis, DNA; Whole Genome Sequencing; Yogurt | 2020 |
Dynamics and interactions of cobalamin and folate status during advanced aging - a longitudinal study in a community-dwelling cohort with multiple follow-ups.
Topics: Aged; Aging; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Independent Living; Longitudinal Studies; Vitamin B 12 | 2020 |
Hyperhomocysteinemia and Low Folate and Vitamin B12 Are Associated with Vascular Dysfunction and Impaired Nitric Oxide Sensitivity in Morbidly Obese Patients.
Topics: Adult; Alcohol Drinking; Arterioles; Bariatric Surgery; Brachial Artery; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Nitric Oxide; Nutritional Status; Obesity, Morbid; Vascular Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Dietary intake, clinical-nutritional status, and homocysteine in hemodialysis subjects: the mediating role of inflammation (NUGE-HD study).
Topics: Aged; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Diabetes Mellitus; Diet; Fatty Acids; Female; Folic Acid; Homocysteine; Humans; Inflammation; Kidney Failure, Chronic; Male; Middle Aged; Nutritional Status; Renal Dialysis; Vitamin B Complex | 2020 |
Simultaneous quantification of intracellular concentrations of clinically important metabolites of folate-homocysteine cycle by LC-MS/MS.
Topics: Cell Line; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Humans; Tandem Mass Spectrometry; Tetrahydrofolates | 2020 |
Maternal folate, one-carbon metabolism and pregnancy outcomes.
Topics: Carbon; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Maternal Nutritional Physiological Phenomena; Pregnancy; Pregnancy Outcome; Premature Birth; Uterine Artery | 2021 |
Hyperhomocysteinemia: an instigating factor for periodontal disease.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Transgenic; Oxidative Stress; Periodontitis; Periodontium | 2021 |
Assessment of Reference Range of Serum Homocysteine from the Post-therapy Values of Cobalamin and Folate Deficiency Patients.
Topics: Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Reference Values; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Which one, gastric parietal cell antibody positivity or hyperhomocysteinemia, is a better biomarker to predict oral mucosal disease patients with vitamin B12 deficiency?
Topics: Biomarkers; Case-Control Studies; Folic Acid; Folic Acid Deficiency; Glossitis; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Parietal Cells, Gastric; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
Prevalence of hyperhomocysteinaemia, selected determinants and relation to hypertension severity in Northern-Nigerian hypertensives: the ABU homocysteine survey.
Topics: Adult; Blood Pressure; Blood Pressure Determination; Case-Control Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Middle Aged; Nigeria; Prevalence; Risk Factors; Surveys and Questionnaires | 2020 |
Novel genes associated with folic acid-mediated metabolism in mouse: A bioinformatics study.
Topics: Animals; Computational Biology; Databases, Genetic; Female; Folic Acid; Gene Expression Profiling; Gene Regulatory Networks; Homocysteine; Kidney; Male; Mice; MicroRNAs; Protein Interaction Maps; Tetratricopeptide Repeat | 2020 |
Relationship between intake and plasma concentrations of vitamin B12 and folate in 873 adults with a physically active lifestyle: a cross-sectional study.
Topics: Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Life Style; Male; Nutritional Status; Vitamin B 12 | 2021 |
High-dose folic acid supplementation results in significant accumulation of unmetabolized homocysteine, leading to severe oxidative stress in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Dietary Supplements; Folic Acid; Homocysteine; Oxidative Stress | 2020 |
B-vitamins and metabolic syndrome in Mesoamerican children and their adult parents.
Topics: Adult; Child; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Metabolic Syndrome; Parents; Vitamin B 12; Vitamin B Complex | 2021 |
Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.
Topics: Aged; Aging; Biomarkers; CpG Islands; DNA Methylation; Epigenesis, Genetic; Folic Acid; Homocysteine; Humans; Longitudinal Studies; Male; Regression Analysis; Veterans; Vitamin B 12; Vitamin B 6 | 2021 |
Lipid Risk Factors in Vitiligo: Homocysteine the Connecting Link?
Topics: Adult; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Lipids; Risk Factors; Vitamin B 12; Vitiligo | 2020 |
Association between plasma levels of homocysteine, folate, and vitamin B
Topics: Aged; Blood Pressure; Cross-Sectional Studies; Diet; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Prevalence; Preventive Medicine; Risk; Surveys and Questionnaires; Vitamin B 12 | 2020 |
Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea.
Topics: Adult; Anemia, Macrocytic; Blood Chemical Analysis; Erythrocyte Indices; Folic Acid; Folic Acid Deficiency; Hematologic Tests; Homocysteine; Humans; Methylmalonic Acid; Republic of Korea; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Vitamin B12, folate levels and somatoform dissociation in conversion disorder.
Topics: Adolescent; Adult; Case-Control Studies; Conversion Disorder; Dissociative Disorders; Folic Acid; Homocysteine; Humans; Turkey; Vitamin B 12; Young Adult | 2020 |
The effect of folate and VitB
Topics: Aged; Cognition; Cognitive Dysfunction; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Treatment Outcome; Vitamin B 12 | 2020 |
[Remethylation disorders: about two cases].
Topics: Alcoholism; Amino Acid Metabolism, Inborn Errors; Diagnosis, Differential; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Humans; Infant, Newborn; Metabolic Networks and Pathways; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Muscle Spasticity; Psychotic Disorders; Vitamin B 12 | 2020 |
B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of transfusion medicine: a cross-sectional study.
Topics: Carbon; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Italy; Male; Transfusion Medicine; Vitamin B 12; Vitamin B Complex | 2021 |
Metabolic Groups Related to Blood Vitamin Levels and Inflammatory Biomarkers in Brazilian Children and Adolescents.
Topics: Adolescent; Biomarkers; Child; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B Complex | 2020 |
Relationship between plasma homocysteine and blood pressure in hypertensive Northern-Nigerians.
Topics: Biomarkers; Blood Pressure; Blood Pressure Determination; Case-Control Studies; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Middle Aged; Risk Factors | 2020 |
Sex Differences in Folate Levels: A Cross Sectional Study of a Large Cohort from Israel.
Topics: Cardiometabolic Risk Factors; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Israel; Male; Middle Aged; Prevalence; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
Hyperhomocysteinemia and Dementia Associated With Severe Cortical Atrophy, but No Amyloid Burden.
Topics: Aged; Alzheimer Disease; Atrophy; Cognitive Dysfunction; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia | 2022 |
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Topics: Adenosylhomocysteinase; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Enzymologic; Glycine Hydroxymethyltransferase; Homocysteine; Homocystinuria; Humans; Liver; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Polyamines | 2021 |
Association between serum folate with inflammatory markers, disease clinical activity and serum homocysteine in patients with inflammatory bowel disease. Does folate level have an effect on maintaining clinical remission?
Topics: Colitis; Folic Acid; Homocysteine; Humans; Inflammatory Bowel Diseases; Vitamin B 12 | 2020 |
POSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS.
Topics: Arginine; Betaine; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Vitamin B 12 | 2020 |
Four families of folate-independent methionine synthases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Archaeal Proteins; Bacterial Proteins; Biosynthetic Pathways; Folic Acid; Homocysteine; Iron-Sulfur Proteins; Methionine; Models, Chemical; Molecular Structure; Multigene Family; Oxygen; Tetrahydrofolates; Vitamin B 12 | 2021 |
Effect of zinc supplementation on hemogram parameters and circulating concentrations of homocysteine, vitamin B
Topics: Adolescent; Child; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Male; Prospective Studies; Vitamin B 12; Zinc | 2021 |
Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease.
Topics: Aged; Bacteria; Case-Control Studies; Databases, Genetic; Dysbiosis; Folic Acid; Folic Acid Deficiency; Gastrointestinal Microbiome; Homocysteine; Humans; Hyperhomocysteinemia; Intestines; Male; Metabolome; Metabolomics; Metagenome; Metagenomics; Middle Aged; Mucins; Parkinson Disease; Polysaccharides; Severity of Illness Index | 2021 |
Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients.
Topics: Adult; Cardiovascular Diseases; Child, Preschool; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Metabolism, Inborn Errors; Methylmalonic Acid; Middle Aged; Retrospective Studies; Vitamin B 12 | 2021 |
Interactions Between Handgrip Strength and Serum Folate and Homocysteine Levels on Cognitive Function in the Elderly Chinese Population.
Topics: Aged; Aged, 80 and over; China; Cognition; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Hand Strength; Homocysteine; Humans; Linear Models; Male; Mental Status and Dementia Tests; Middle Aged | 2021 |
Associations of Early Pregnancy and Neonatal Circulating Folate, Vitamin B-12, and Homocysteine Concentrations with Cardiometabolic Risk Factors in Children at 10 y of Age.
Topics: Cardiometabolic Risk Factors; Cardiovascular Diseases; Child; Female; Folic Acid; Glucose; Homocysteine; Humans; Infant, Newborn; Micronutrients; Overweight; Pregnancy; Prospective Studies; Risk Factors; Vitamin B 12; Vitamins | 2021 |
Causal Effects of Homocysteine, Folate, and Cobalamin on Kidney Function: A Mendelian Randomization Study.
Topics: Alleles; Female; Folic Acid; Genome-Wide Association Study; Glomerular Filtration Rate; Homocysteine; Humans; Kidney; Male; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Vitamin B 12 | 2021 |
PECULIARITIES OF CHANGES IN HOMOCYSTEINE LEVELS DEPENDING ON VITAMIN STATUS IN PATIENTS WITH CHRONIC PANCREATITIS AND TYPE 2 DIABETES.
Topics: Diabetes Mellitus, Type 2; Folic Acid; Homocysteine; Humans; Pancreatitis, Chronic; Vitamin B 12 | 2021 |
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran.
Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult | 2021 |
Reference Interval for Korean Serum Folate Assay Traceable to the WHO International Standard.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Reference Values; Republic of Korea; Retrospective Studies; Vitamin B 12; World Health Organization | 2021 |
Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study.
Topics: Cardiovascular Diseases; Folic Acid; Homocysteine; Humans; Mendelian Randomization Analysis; Risk Factors; Vitamin B 12; Vitamin B Complex | 2021 |
Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study.
Topics: Adult; Cohort Studies; Epigenesis, Genetic; Epigenomics; Female; Fetal Blood; Folic Acid; Gestational Age; Homocysteine; Humans; Infant, Newborn; Male; Pregnancy; Prospective Studies; Vitamin B 12 | 2021 |
Hyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment.
Topics: Adolescent; Adult; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Metabolome; Vitamin B 12; Young Adult | 2021 |
Folate and vitamin B12 status: associations with maternal glucose and neonatal DNA methylation sites related to dysglycaemia, in pregnant women with obesity.
Topics: Diabetes, Gestational; DNA Methylation; Female; Folic Acid; Glucose; Homocysteine; Humans; Infant, Newborn; Obesity; Pregnancy; Pregnant Women; Vitamin B 12 | 2022 |
Association Between Homocysteine and Vitamin Levels in Demented Patients.
Topics: Aged; Aged, 80 and over; Dementia; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Thiamine; Vitamin B 12; Vitamin B 6 | 2021 |
Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.
Topics: Animals; Body Weight; Brain; Diet; Dose-Response Relationship, Drug; Drug Interactions; Epigenesis, Genetic; Female; Fetus; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation, Developmental; Genomic Imprinting; Homocysteine; Kidney; Liver; Male; Mice; Placenta; Pregnancy; Pregnancy Complications; Receptor, IGF Type 2; RNA, Long Noncoding; RNA, Messenger; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
Effect of methylenetetrahydrofolate reductase gene polymorphisms and oxidative stress in silent brain infarction.
Topics: Adult; Aged; Alleles; Biomarkers; Brain Infarction; Female; Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Magnetic Resonance Imaging; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidative Stress; Polymorphism, Genetic; Serum Albumin; White Matter | 2021 |
Reclaiming the importance of homocysteine as a marker of cardiovascular and neurologic disease.
Topics: Biomarkers; Cardiovascular System; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2021 |
A study of hyperhomocysteinemia in cerebral venous sinus thrombosis.
Topics: Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; India; Methylenetetrahydrofolate Reductase (NADPH2); Risk Factors; Sinus Thrombosis, Intracranial; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Homocysteine, vitamin B status and MTHFR polymorphisms in Italian infertile women.
Topics: Female; Folic Acid; Genotype; Homocysteine; Humans; Infertility, Female; Italy; Methylenetetrahydrofolate Reductase (NADPH2); Vitamin B 12; Vitamin B Complex | 2021 |
Higher serum homocysteine level and frequency of hyperhomocysteinemia in carcinoembryonic antigen-positive or squamous cell carcinoma-antigen-positive oral leukoplakia patients.
Topics: Antigens, Neoplasm; Autoantibodies; Carcinoembryonic Antigen; Erythrocyte Indices; Folic Acid; Hemoglobins; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Leukoplakia, Oral; Parietal Cells, Gastric; Serpins; Vitamin B 12 | 2021 |
Hyperhomocysteinemia in patients with acute porphyrias: a possible effect of ALAS1 modulation by siRNAm therapy and its control by vitamin supplementation.
Topics: Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Porphyria, Acute Intermittent; Vitamin B 12; Vitamins | 2021 |
Higher serum homocysteine and lower thyroid hormone levels in pregnant women are associated with neural tube defects.
Topics: Animals; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Mice; Neural Tube Defects; Pregnancy; Pregnant Women; Thyroid Hormones; Thyroxine | 2021 |
Serum pyridoxine, folate, cobalamin, and homocysteine levels in children presenting with vasovagal syncope.
Topics: Adolescent; Blood Pressure Monitoring, Ambulatory; Child; Folic Acid; Homocysteine; Humans; Pyridoxine; Syncope, Vasovagal; Vitamin B 12 | 2022 |
Investigating the causality of metabolites involved in one-carbon metabolism with the risk and age at onset of Parkinson's disease: A two-sample mendelian randomization study.
Topics: Age of Onset; Dietary Supplements; Disease Susceptibility; Folic Acid; Genome-Wide Association Study; Homocysteine; Mendelian Randomization Analysis; Negative Results; Parkinson Disease; Risk; Vitamin B 12; Vitamin B 6 | 2021 |
Letter to the editor regarding megaloblastic anemia with elevated vitamin B12.
Topics: Aged; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Homocysteine; Humans; Injections, Intramuscular; Male; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2021 |
Insufficient S-Sulfhydration of Methylenetetrahydrofolate Reductase Contributes to the Progress of Hyperhomocysteinemia.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Oxidation-Reduction; Vitamin B 12 | 2022 |
Effect of nickel on red blood cell parameters and on serum vitamin B12, folate and homocysteine concentrations during pregnancy with and without anemia.
Topics: Anemia; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Nickel; Pregnancy; Vitamin B 12 | 2021 |
Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age.
Topics: Adult; Atherosclerosis; Cardiometabolic Risk Factors; Carotid Intima-Media Thickness; Child; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Male; Maternal Exposure; Maternal Nutritional Physiological Phenomena; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Vitamin B 12 | 2021 |
Prevalence of hyperhomocysteinemia (HHcy) and its major determinants among hypertensive patients over 35 years of age.
Topics: Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Prevalence; Risk Factors; Vitamin B 12 | 2022 |
Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction-A cross-sectional study.
Topics: Cross-Sectional Studies; Erectile Dysfunction; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12 | 2021 |
Genetically predicted circulating homocysteine, vitamin B12, and folate levels and risk of multiple sclerosis: evidence from a two-sample Mendelian randomization analysis.
Topics: Folic Acid; Genome-Wide Association Study; Homocysteine; Humans; Mendelian Randomization Analysis; Multiple Sclerosis; Vitamin B 12 | 2021 |
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; Vitamin B 12 | 2023 |
The Relationship between Folic Acid and Vitamin B12 Serum Levels with High Sensitivity C-reactive Protein and Homocysteine in Chronic Hemodialysis Patients: A Cross-sectional Study.
Topics: C-Reactive Protein; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Renal Dialysis; Vitamin B 12 | 2021 |
Perspective: The High-Folate-Low-Vitamin B-12 Interaction Is a Novel Cause of Vitamin B-12 Depletion with a Specific Etiology-A Hypothesis.
Topics: Folic Acid; Homocysteine; Humans; Malnutrition; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia.
Topics: Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Prospective Studies; Schizophrenia | 2021 |
The characteristics of clinical laboratory indicators in anticardiolipin antibody positive cerebral infarction patients.
Topics: Aged; Aged, 80 and over; Antibodies, Anticardiolipin; Blood Coagulation; Blood Platelets; Cerebral Infarction; Clinical Laboratory Techniques; Creatine Kinase; Diabetes Complications; Diabetes Mellitus; Female; Folic Acid; Homocysteine; Humans; Hypertension; Immunity; L-Lactate Dehydrogenase; Lipids; Male; Middle Aged; Thyroid Hormones; Vitamin B 12 | 2022 |
Imbalanced Folate and Vitamin B12 in the Third Trimester of Pregnancy and its Association with Birthweight and Child Growth up to 2 Years.
Topics: Birth Weight; Cohort Studies; Female; Folic Acid; Homocysteine; Humans; Infant; Infant, Newborn; Pregnancy; Pregnancy Trimester, Third; Vitamin B 12 | 2022 |
Dietary Intake of Folate and Assessment of the Folate Deficiency Prevalence in Slovenia Using Serum Biomarkers.
Topics: Adolescent; Adult; Aged; Biomarkers; Child; Diet; Eating; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male; Middle Aged; Nutritional Status; Pregnancy; Pregnancy Complications; Prevalence; Propensity Score; Slovenia; Young Adult | 2021 |
5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology.
Topics: Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infertility, Female; Live Birth; Pregnancy; Reproductive Techniques, Assisted; Retrospective Studies; Tetrahydrofolates; Vitamin B 12; Vitamin B Complex | 2021 |
Polymorphisms in vitamin B12 and folate metabolising genes and their association with adverse pregnancy outcome: secondary analysis of a population based case control study.
Topics: Case-Control Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Pregnancy Outcome; Premature Birth; Vitamin B 12 | 2022 |
One-carbon metabolism during the menstrual cycle and pregnancy.
Topics: Carbon; Estradiol; Female; Folic Acid; Homocysteine; Humans; Menstrual Cycle; Pregnancy; S-Adenosylmethionine; Vitamin B 12 | 2021 |
Plasma homocysteine is associated with nonproliferative retinopathy in patients with type 2 diabetes without renal disease.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2022 |
New Evidence for Homocysteine Lowering for Management of Treatment-Resistant Hypertension.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Vitamin B Complex | 2022 |
Reference intervals for plasma vitamin B12 and plasma/serum methylmalonic acid in Danish children, adults and elderly.
Topics: Adult; Aged; Child; Denmark; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Reference Values; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Associations between Genetic Variants and Blood Biomarkers of One-Carbon Metabolism in Postmenopausal Women from the Women's Health Initiative Observational Study.
Topics: Aged; Biomarkers; Carbon; Female; Folic Acid; Genotype; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Postmenopause; Women's Health | 2022 |
Associations of Homocysteine with B Vitamins and Zinc in Serum Levels of Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Male; Vitamin B 12; Vitamin B Complex; Zinc | 2021 |
Letter to the Editor: the effect of folic acid supplementation on oxidative stress is strictly related to serum homocysteine levels.
Topics: Animals; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Ischemia; Ovarian Torsion; Oxidative Stress; Rats; Reperfusion Injury | 2022 |
Folate Deficiency: A Possible Association with Congenital Heart Defects.
Topics: Cross-Sectional Studies; Folic Acid; Folic Acid Deficiency; Heart Defects, Congenital; Homocysteine; Humans; Infant; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Folic Acid Supplementation in Early Pregnancy, Homocysteine Concentration, and Risk of Gestational Diabetes Mellitus.
Topics: Diabetes, Gestational; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Pregnancy; Prospective Studies | 2022 |
Folate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells.
Topics: Activating Transcription Factor 4; Apoptosis; bcl-2-Associated X Protein; Cell Differentiation; Endoplasmic Reticulum Stress; Folic Acid; Homocysteine; Osteoblasts | 2022 |
RBC Folate and Serum Folate, Vitamin B-12, and Homocysteine in Chinese Couples Prepregnancy in the Shanghai Preconception Cohort.
Topics: Biomarkers; China; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
Serum Folate deficiency in HCV related Hepatocellular Carcinoma.
Topics: Carcinoma, Hepatocellular; Folic Acid; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Homocysteine; Humans; Liver Cirrhosis; Liver Neoplasms; RNA | 2022 |
Association Between Homocysteine, Frailty and Biomechanical Response of the CNS in NPH-Suspected Patients.
Topics: Aged; Brain; Folic Acid; Frailty; Homocysteine; Humans; Hydrocephalus, Normal Pressure | 2022 |
Folate metabolism abnormalities in infertile patients with endometriosis.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Endometriosis; Female; Ferredoxin-NADP Reductase; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy | 2022 |
Vitamin B12 and chronic kidney disease.
Topics: Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Renal Insufficiency, Chronic; Vitamin B 12 | 2022 |
Lower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women.
Topics: Betaine; Biomarkers; Choline; Fatty Liver; Female; Folic Acid; Glutathione; Homocysteine; Humans; Postmenopause | 2022 |
Influences of Vitamin B
Topics: Aged; Aged, 80 and over; Atrophy; Cognition; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
A Study on the Levels of Folic Acid, Vitamin B12 and Plasma Homocysteine in Patients with Chronic Kidney Disease.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Vitamin B 12 | 2022 |
The association between vitamin B12 and plasma homocysteine levels with episodic memory and the volume of memory related brain structures in middle-aged individuals: a retrospective correlational study.
Topics: Adult; Brain; Female; Folic Acid; Homocysteine; Humans; Male; Memory, Episodic; Middle Aged; Retrospective Studies; Vitamin B 12 | 2022 |
Vitamin B12 as a cholinergic system modulator and blood brain barrier integrity restorer in Alzheimer's disease.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinergic Agents; Folic Acid; Homocysteine; Humans; Receptors, Cholinergic; Vitamin B 12 | 2022 |
Vitamin B-12 malabsorption and renal function are critical considerations in studies of folate and vitamin B-12 interactions in cognitive performance: NHANES 2011-2014.
Topics: Aged; Cognition; Dietary Supplements; Folic Acid; Homocysteine; Humans; Kidney; Methylmalonic Acid; Nutrition Surveys; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
Muddy water: Additional observational data cannot aid in determining whether there is a physiological interaction between low vitamin B12 and high folate in cognitive health.
Topics: Cognition; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
The potential of folic acid and homocysteine as novel serum markers for venous thromboembolism in cancer patients.
Topics: Biomarkers; Factor VIII; Folic Acid; Homocysteine; Humans; Neoplasms; Tissue Plasminogen Activator; Venous Thromboembolism | 2022 |
Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring.
Topics: Birth Weight; Child; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Pregnancy; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency | 2023 |
Association of MTHFR 677C>T polymorphism with pregnancy outcomes in IVF/ICSI-ET recipients with adequate synthetic folic acid supplementation.
Topics: Embryo Transfer; Female; Fertilization in Vitro; Folic Acid; Homocysteine; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Pregnancy Outcome; Premature Birth; Retrospective Studies; Semen; Sperm Injections, Intracytoplasmic | 2022 |
Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
Topics: Aged; Apolipoprotein E4; China; Cognitive Dysfunction; Cohort Studies; Folic Acid; Homocysteine; Humans; Prospective Studies; Vitamin B 12 | 2022 |
Fetal hyperhomocysteinemia is associated with placental inflammation and early breakdown of maternal-fetal tolerance in pre-term birth.
Topics: Biomarkers; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Infant, Newborn; Inflammation; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Placenta; Pregnancy; Premature Birth; Term Birth; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vitamin B 12 | 2022 |
Effect of Beer Consumption on Methylation and Redox Metabolism.
Topics: Antioxidants; Apolipoproteins; Beer; Betaine; Cholesterol, LDL; Folic Acid; Homocysteine; Humans; Male; Methylation; Oxidation-Reduction; Superoxide Dismutase; Uric Acid; Vitamin B 6 | 2022 |
Tetrahydrobiopterin deficiency in schizophrenia: Biochemical and clinical aspects.
Topics: C-Reactive Protein; Case-Control Studies; Folic Acid; Homocysteine; Humans; Phenylketonurias; Schizophrenia; Vitamin B 12 | 2022 |
Vitamin B
Topics: Animals; Fatty Acids; Fibrosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Qa-SNARE Proteins; Vitamin B 12; Vitamins | 2022 |
The association between vitamin B12, folate, homocysteine levels, and carotid intima-media thickness in children with obesity: a cross-sectional study.
Topics: Adolescent; Adult; Carotid Intima-Media Thickness; Child; Child, Preschool; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; Obesity; Risk Factors; Vitamin B 12 | 2022 |
Association of methylenetetrahydrofolate reductase
Topics: Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; India; Infant, Newborn; Longitudinal Studies; Methylenetetrahydrofolate Reductase (NADPH2); Parturition; Polymorphism, Genetic; Pregnancy; Pregnant Women; Premature Birth; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Relationships of Serum Homocysteine, Vitamin B
Topics: Case-Control Studies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Rosacea; Vitamin B 12; Vitamins | 2022 |
Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight.
Topics: Adult; Arsenic; Arsenicals; Biomarkers; Birth Weight; Carbon; Female; Folic Acid; Homocysteine; Humans; Methylation; Pregnancy; Prenatal Exposure Delayed Effects; Vitamin B 12 | 2022 |
Ischemic Stroke and Dietary Vitamin B12 Deficiency in Old-Aged Females: Impaired Motor Function, Increased Ischemic Damage Size, and Changed Metabolite Profiles in Brain and Cecum Tissue.
Topics: Animals; Brain; Cecum; Diet; Female; Folic Acid; Homocysteine; Ischemic Stroke; Mice; Stroke; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Proton pump inhibitor use and its effect on vitamin B12 and homocysteine levels among men and women: A large cross-sectional study.
Topics: Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Proton Pump Inhibitors; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Association between MTHFR polymorphism and seizure control in epileptic patients with hyperhomocysteinaemia
Topics: Epilepsy; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Seizures; Vitamin B 12; Vitamins | 2022 |
Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran.
Topics: Clinical Trials as Topic; Cystathionine beta-Synthase; Folic Acid; Heme; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Porphyrias, Hepatic; Pyridoxine; RNA, Small Interfering; Sulfur; Vitamin B 6 | 2022 |
Effect of methylenetetrahydrofolate reductase C677T polymorphism on serum folate but not vitamin B12 levels in patients with H-type hypertension.
Topics: Antihypertensive Agents; Female; Folic Acid; Genotype; Homocysteine; Humans; Hypertension; Male; Methylenetetrahydrofolate Reductase (NADPH2); Vitamin B 12 | 2022 |
Hyperhomocysteinemia Promotes Cardiac Hypertrophy in Hypertension.
Topics: Animals; Calcineurin; Cardiomegaly; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Mice; Myocytes, Cardiac; NFATC Transcription Factors; Rats; Retrospective Studies | 2022 |
A Retrospective Study on Clinical Assessment of Cognitive Impairment in a Swedish Cohort: Is There Inequality Between Natives and Foreign-Born?
Topics: Albumins; Alzheimer Disease; Atrophy; Biomarkers; Calcium; Cognitive Dysfunction; Folic Acid; Homocysteine; Humans; Magnetic Resonance Imaging; Retrospective Studies; Sweden; Thyrotropin; Vitamin B 12 | 2022 |
One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults.
Topics: Aged; Biomarkers; Carbon; Cognitive Dysfunction; Dementia; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2022 |
Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development.
Topics: Animals; Blastocyst; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Placenta; Pregnancy; Trophoblasts; Unfolded Protein Response; Vitamins | 2022 |
Overlapping sperm damages from vitamin B or D deficiency in mice: Insights into the role of clinical supplementations.
Topics: Animals; Body Weight; Dietary Supplements; Folic Acid; Homocysteine; Male; Mice; Semen; Spermatozoa; Vitamin B 12; Vitamins | 2022 |
Quantitation of 5-Methyltetrahydrofolate in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry.
Topics: Chromatography, Liquid; DNA; Folic Acid; Homocysteine; Isotopes; Lipids; RNA; Tandem Mass Spectrometry; Tetrahydrofolates | 2022 |
Maternal Vitamin B
Topics: Child; Female; Folic Acid; Homocysteine; Humans; Infant; Infant, Newborn; Neonatal Screening; Pregnancy; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
Serum Homocysteine, Vitamin B12, Folate, and Their Association with Mild Cognitive Impairment and Subtypes of Dementia.
Topics: Alzheimer Disease; Cognitive Dysfunction; Dementia, Vascular; Folic Acid; Frontotemporal Dementia; Homocysteine; Humans; Hyperhomocysteinemia; Vitamin B 12 | 2022 |
Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Caenorhabditis elegans; Carbon; Dithiothreitol; Folic Acid; Homocysteine; Hydrogen Sulfide; Ligases; Lipids; Mercaptoethanol; Methionine; Methyltransferases; Nucleic Acids; Oxygen; Reducing Agents; S-Adenosylmethionine; Sulfhydryl Compounds; Vitamin B 12; Vitamins | 2022 |
Simultaneous estimation of total homocysteine and methylmalonic-acid using LC-MS/MS: Clinical application in adult and pediatric.
Topics: Adult; Biomarkers; Child; Chromatography, Liquid; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Pediatrics; Tandem Mass Spectrometry; Vitamin B 12 | 2022 |
Different effects of maternal homocysteine concentration, MTHFR and MTRR genetic polymorphisms on the occurrence of fetal aneuploidy.
Topics: Aneuploidy; Case-Control Studies; Female; Fetus; Flavoproteins; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Trisomy; Turner Syndrome | 2022 |
Distribution and Determinants of Plasma Homocysteine Levels in a Preconception Population: A Retrospective Single-Center Study.
Topics: China; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Retrospective Studies | 2022 |
Elevated homocysteine levels: What inborn errors of metabolism might we be missing?
Topics: Adult; Female; Folic Acid; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Metabolism, Inborn Errors; Retrospective Studies; Vitamin B 12 | 2023 |
[Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases].
Topics: Colitis, Ulcerative; Contraceptive Agents; Crohn Disease; Female; Fibrinogen; Folic Acid; Homocysteine; Humans; Inflammatory Bowel Diseases; Male; Methylenetetrahydrofolate Reductase (NADPH2); Risk Factors | 2022 |
Hearing Function and Nutritional Status in Aviation Pilots from Spain Exposed to High Acoustic Damage.
Topics: Acoustics; Aviation; Biomarkers; Folic Acid; Hearing; Homocysteine; Nutritional Status; Spain; Vitamin B 12; Vitamins | 2022 |
Folic acid incorporated nitrogen-doped carbon dots as a turn-on fluorescence probe for homocysteine detection.
Topics: Carbon; Fluorescent Dyes; Folic Acid; Homocysteine; Nitrogen; Quantum Dots; Spectrometry, Fluorescence | 2023 |
Reduced circulating folate among older adults caused by continuous work: nested cross-sectional study conducted in a country with folic acid fortification program.
Topics: Aged; Cross-Sectional Studies; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
Effects of three-months folate supplementation on early vascular abnormalities in hyperhomocysteinemic patients with epilepsy.
Topics: Dietary Supplements; Epilepsy; Folic Acid; Homocysteine; Humans; Matrix Metalloproteinase 9; Tissue Inhibitor of Metalloproteinase-1 | 2022 |
The role of the deficiency of vitamin B12 and folic acid on homocysteinemia in children with Turner syndrome.
Topics: Child; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Turner Syndrome; Vitamin B 12; Vitamin B 12 Deficiency | 2023 |
The acute postprandial response of homocysteine to multivitamin and mineral supplementation with a standard meal is not impaired in older compared to younger adults.
Topics: Aged; Dietary Supplements; Folic Acid; Homocysteine; Humans; Minerals; Vitamin B 12; Vitamin B Complex | 2023 |
An assessment of serum vitamin B12 and folate in patients with Crohn's disease.
Topics: Crohn Disease; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Pre-natal dietary imbalance of folic acid and vitamin B12 deficiency adversely impacts placental development and fetal growth.
Topics: Animals; Diet; Female; Fetal Development; Fetal Weight; Folic Acid; Homocysteine; Mice; Placenta; Placentation; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency | 2023 |
Association of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms with serum folate, cobalanin and homocysteine concentrations in Greek adults.
Topics: Adult; Female; Folic Acid; Genotype; Greece; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vitamin B 12 | 2023 |
Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian.
Topics: Aged; Australia; Folic Acid; Homocysteine; Humans; Magnesium; Micronutrients; Sleep; Telomere; Vitamin B 12 | 2023 |
Comparison of blood levels of vitamin B12, folic acid, riboflavin, and homocysteine in keratoconus and healthy subjects.
Topics: Adolescent; Adult; Cross-Sectional Studies; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Keratoconus; Riboflavin; Vitamin B 12; Young Adult | 2023 |
Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
Topics: Adult; Cardiovascular Diseases; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Male; Neoplasms; Prospective Studies; Republic of Korea; Risk Factors | 2023 |
A Potential Strategy for Atherosclerosis Prevention in Modernizing China - Hyperhomocysteinemia, MTHFR C677T Polymorphism and Air Pollution (PM2.5) on Atherogenesis in Chinese Adults.
Topics: Air Pollution; Atherosclerosis; Carotid Intima-Media Thickness; East Asian People; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Particulate Matter | 2023 |
Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank.
Topics: Biological Specimen Banks; Biomarkers; Female; Folic Acid; Homocysteine; Humans; Mendelian Randomization Analysis; Pregnancy; United Kingdom; Vitamin A; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin K | 2023 |
Possible Combined Effects of Plasma Folate Levels, Global DNA Methylation, and Blood Cadmium Concentrations on Renal Cell Carcinoma.
Topics: Cadmium; Carcinoma, Renal Cell; Case-Control Studies; DNA Methylation; Folic Acid; Homocysteine; Humans; Kidney Neoplasms; Vitamin B 12; Vitamins | 2023 |
MTHFR C677T polymorphism, homocysteine, burden, and location of AMI and ACI.
Topics: Brain Ischemia; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Stroke | 2023 |
Diagnostic Value of ATG5, Apo-Lipoprotein B-48, Thyroid Hormones, and Homocysteine in Patients with Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Apolipoprotein B-48; Autophagy-Related Protein 5; Folic Acid; Homocysteine; Humans; Middle Aged; Thyroid Hormones; Vitamin B 12 | 2023 |
Homocysteine exchange across skeletal muscle in patients with chronic kidney disease.
Topics: Folic Acid; Homocysteine; Humans; Muscle, Skeletal; Renal Dialysis; Renal Insufficiency, Chronic; Vitamin B 12 | 2023 |
Use of serum folate and vitamin B
Topics: Coronary Artery Disease; Folic Acid; Homocysteine; Humans; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2023 |
An incorrect cutoff was used, leading to null results.
Topics: Folic Acid; Homocysteine; Humans; Negative Results; Vitamin B 12; Vitamin B 12 Deficiency | 2023 |
Methylenetetrahydrofolate reductase polymorphisms and elevated plasma homocysteine levels in small vessel disease.
Topics: Folic Acid; Gene Frequency; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2023 |
Associations of Homocysteine, Folate, and Vitamin B12 with Osteoarthritis: A Mendelian Randomization Study.
Topics: Female; Folic Acid; Homocysteine; Humans; Mendelian Randomization Analysis; Osteoarthritis; Risk Factors; Vitamin B 12 | 2023 |
Vitamin B6 Levels and Impaired Folate Status but Not Vitamin B12 Associated with Low Birth Weight: Results from the MAASTHI Birth Cohort in South India.
Topics: Birth Cohort; Birth Weight; Female; Folic Acid; Homocysteine; Humans; India; Infant, Low Birth Weight; Infant, Newborn; Pregnancy; Prospective Studies; Pyridoxine; Vitamin B 12; Vitamin B 6 | 2023 |
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Topics: Adolescent; Female; Folic Acid; Genotype; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Intracranial Thrombosis; Loss of Heterozygosity; Methylenetetrahydrofolate Reductase (NADPH2); Venous Thrombosis | 2023 |
Evaluation of homocysteine, vitamin, and trace element levels in women with gallstones.
Topics: Copper; Female; Folic Acid; Gallstones; Homocysteine; Humans; Nickel; Selenium; Trace Elements; Vitamin B 12; Vitamins; Zinc | 2023 |
Ischaemic stroke with multi-focal venous and arterial thrombosis due to hyperhomocysteinemia: anabolic androgenic steroid use and MTHFR c.667 C > T variant - a case report.
Topics: Anabolic Androgenic Steroids; Brain Ischemia; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Ischemic Stroke; Male; Methylenetetrahydrofolate Reductase (NADPH2); Risk Factors; Stroke; Thrombosis; Vitamin B 12 | 2023 |
Association of MTHFR C667T Polymorphism, Homocysteine, and B Vitamins with Senile Cataract.
Topics: Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Vitamin B 12; Vitamin B Complex | 2023 |
Dapagliflozin's effect on serum homocysteine in patients with hypertension complicated with insulin resistance.
Topics: Case-Control Studies; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Insulin Resistance; Retrospective Studies | 2023 |
Folic acid enhances the cardiovascular protective effect of amlodipine in renal hypertensive rats with elevated homocysteine.
Topics: Amlodipine; Animals; Endothelial Cells; Folic Acid; Homocysteine; Hyperhomocysteinemia; Hypertension; Kidney; Rats | 2023 |
Effect of Ethanol-Induced Methyl Donors Consumption on the State of Hypomethylation in Cervical Cancer.
Topics: Animals; Cell Line, Tumor; DNA; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Methionine; Mice; RNA, Messenger; Uterine Cervical Neoplasms | 2023 |
Gender-specific association of SLC19A1 and MTHFR genetic polymorphism with oxidative stress biomarkers and plasma folate levels in older adults.
Topics: Aged; Antioxidants; Biomarkers; Female; Folic Acid; Folic Acid Deficiency; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidative Stress; Polymorphism, Genetic; Reduced Folate Carrier Protein; Sex Characteristics; Superoxide Dismutase | 2023 |
The Importance of Serum Homocysteine as a Biomarker in Diabetic and Obese COVID-19 Patients.
Topics: Biomarkers; COVID-19; Diabetes Mellitus; Female; Folic Acid; Homocysteine; Humans; Interleukin-6; Male; Obesity; Vitamin B 12 | 2023 |
MTHFR C677T Polymorphism, Plasma Homocysteine, and PDGF-AA Levels and Transcranial Doppler Velocity in Children With Sickle Cell Disease.
Topics: Anemia, Sickle Cell; Child; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Platelet-Derived Growth Factor | 2023 |
Associations of serum 25-hydroxyvitamin D with serum folate, cobalanin, and homocysteine concentrations and methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in healthy adults.
Topics: Adult; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic | 2023 |
Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women.
Topics: Adolescent; Adult; Betaine; Carbon; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Pregnancy; S-Adenosylmethionine; Young Adult | 2023 |
The Utilization of Serum Folate and Homocysteine Tests and the Prevalence of Folate Deficiency in Reproductive-Age Korean Women during the COVID-19 Pandemic.
Topics: COVID-19; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Pandemics; Prevalence; Republic of Korea; Vitamin B 12; Vitamin B 12 Deficiency | 2023 |
Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study.
Topics: Abortion, Spontaneous; Cross-Sectional Studies; Dietary Supplements; Embryo Transfer; Female; Fertilization in Vitro; Folic Acid; Homocysteine; Hospitals; Humans; Infant, Newborn; Infertility, Female; Male; Pregnancy; Retrospective Studies; Semen | 2023 |
Association of B vitamin intake and total homocysteine levels with all-cause and cause-specific mortality in central obesity.
Topics: Adult; Cause of Death; Folic Acid; Homocysteine; Humans; Middle Aged; Nutrition Surveys; Obesity, Abdominal; Pyridoxine; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2023 |
Exploring the Interplay Between Vitamin B
Topics: Biomarkers; Carbon; DNA Methylation; Folic Acid; Homocysteine; Humans; Male; Nutritional Status; Vitamin B 12; Vitamins | 2023 |
The importance of preconception Hcy testing: identification of a folate trap syndrome in a woman attending an assisted reproduction program.
Topics: Female; Folic Acid; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Reproduction; S-Adenosylmethionine | 2023 |
Associations of Serum Total Homocysteine Levels with Various Demographic, Clinical and Genetic Characteristics in Healthy Greek Adults.
Topics: Adult; Demography; Folic Acid; Genotype; Greece; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic | 2023 |
Neurovascular Correlates of Cobalamin, Folate, and Homocysteine in Dementia.
Topics: Alzheimer Disease; Brain; Brain Ischemia; Dementia, Vascular; Folic Acid; Homocysteine; Humans; Vitamin B 12 | 2023 |
Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women.
Topics: Antioxidants; Diet; Dietary Fiber; East Asian People; Female; Folic Acid; Homocysteine; Humans; Vitamin B 12; Vitamins | 2023 |
The effects of folinic acid and l-methylfolate supplementation on serum total homocysteine levels in healthy adults.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged | 2023 |