homocysteine has been researched along with adenosine in 215 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 135 (62.79) | 18.7374 |
| 1990's | 22 (10.23) | 18.2507 |
| 2000's | 39 (18.14) | 29.6817 |
| 2010's | 18 (8.37) | 24.3611 |
| 2020's | 1 (0.47) | 2.80 |
| Authors | Studies |
|---|---|
| Lawrence, F; Pierré, A; Richou, M; Robert-Géro, M; Vigier, P | 1 |
| Berneman, A; Blanchard, P; Farrugia, G; Lawrence, F; Lederer, E; Robert-Géro, M; Vigier, P | 1 |
| Saebø, J; Ueland, PM | 1 |
| Hershfield, MS; Kredich, NM | 3 |
| Saebø, J; Ueland, M | 1 |
| Deeprose, RD; Duncan, GS; Wolberg, G; Zimmerman, TP | 1 |
| Mertens, PP; Payne, CC | 2 |
| Johnston, JM; Kredich, NM | 1 |
| Deeprose, RD; Duncan, GS; Harvey, RJ; Wolberg, G; Zimmerman, TP | 1 |
| Kredich, NM; Martin, DV | 1 |
| Hibasami, H; Pegg, AE | 1 |
| Casellas, P; Jeanteur, P | 1 |
| Eloranta, T; Kajander, O; Raina, A | 1 |
| Lin, RL; Narasimhachari, N | 1 |
| Dainko, JL; Schlenk, F | 1 |
| Halper, LA; Norton, SJ | 1 |
| Duerre, JA; Walker, RD | 1 |
| Borchardt, RT; Wu, YS | 2 |
| Follmann, H; Kuntz, I; Zacharias, W | 1 |
| Borst, MM; Coenen, HH; Deussen, A; Feinendegen, LE; Hamacher, K; Henrich, M; Herzog, H; Schrader, J; Stöcklin, G | 1 |
| Tsiftsoglou, AS; Vizirianakis, IS; Wong, W | 1 |
| Doherty, NS; Gieske, TH; Raddatz, R; Stephens, D | 1 |
| Aarbakke, J; Bang, BE; Endresen, PC; Møller, C; Prytz, PS | 1 |
| de Blois, MC; Lejeune, J; Peeters, M; Rethore, MO | 1 |
| Carney, DF; Papadimitriou, JC; Shin, ML | 1 |
| Liteplo, RG | 1 |
| Borchardt, RT; Kramer, DL; Porter, CW; Sufrin, JR | 1 |
| Lefort, J; Randon, J; Vargaftig, BB | 1 |
| Borchardt, RT; Borcherding, DR; Hasobe, M; Keller, BT; Mckee, JG | 1 |
| Gharib, A; Reynaud, D; Sarda, N | 1 |
| Balzarini, J; Cools, M; De Clercq, E | 1 |
| Borchardt, RT; Hasobe, M; McKee, JG | 1 |
| Deussen, A; Lloyd, HG; Schrader, J | 1 |
| Borchardt, RT; Cools, M; De Clercq, E; Hasobe, M; Ishii, H; McKee, JG | 1 |
| DeMeester, CA; Pike, MC | 1 |
| Djurhuus, R; Svardal, AM; Ueland, PM | 1 |
| Henson, PM; Riches, DW; Stanworth, DR; Watkins, JL | 1 |
| Newman, ME | 1 |
| Aultman, M; Gerrard, TL; Kaplan, AM; Squire, C; Strawson, J | 1 |
| Chu, RC; Hall, CA | 1 |
| Aarsaether, N; Aarsland, A; Berge, RK; Svardal, AM; Ueland, PM | 1 |
| Adams, R; Drachman, DB; Kuncl, RW | 1 |
| Campochiaro, PA; Hackett, SF | 1 |
| Borst, M; Deussen, A; Schrader, J | 1 |
| Borst, M; Deussen, A; Kroll, K; Schrader, J | 1 |
| Deussen, A; Lloyd, HG; Schrader, J; Wuppermann, H | 1 |
| Chiang, PK; Gordon, RK; Miura, GA; Montgomery, JA | 1 |
| Heike, T; Katamura, K; Kubota, M; Mikawa, H; Shinomiya, K | 1 |
| Carrera, CJ; Carson, DA; Kajander, EO; Kubota, M; Montgomery, JA | 1 |
| McIlwain, H; Poll, JD | 1 |
| Coindet, J; Gharib, A; Jouvet, M; Pacheco, H; Sarda, N | 1 |
| Djurhuus, R; Svardal, A; Ueland, PM | 1 |
| Clarke, S; Lou, LL | 1 |
| Djurhuus, R; Refsum, H; Svardal, AM; Ueland, PM | 1 |
| Silverstein, SC; Sung, SJ | 1 |
| Samet, MK | 1 |
| Archer, S; Chan, VL; Ho, JH; Juranka, PF | 1 |
| Carson, DA; Iizasa, T | 1 |
| Auge, J; Christa, L; Kersual, J; Perignon, JL | 1 |
| Achterberg, PW; de Jong, JW; de Tombe, PP; Harmsen, E | 1 |
| Lechner, J; Sumper, M; Wieland, F | 1 |
| Brodie, AE; Reed, DJ | 1 |
| Hirayama, T; Kato, I; Matsuda, F; Noda, M | 1 |
| Carnegie, PR; Jones, GM | 1 |
| Eskin, B; Linn, S | 2 |
| Kerr, SJ | 1 |
| Baxter, CS; Byvoet, P | 2 |
| Kutzbach, C; Stokstad, EL | 1 |
| Finkelstein, JD; Harris, BJ; Kyle, WE | 1 |
| Barth, H; Lorenz, W; Niemeyer, I | 1 |
| Bussolotti, DL; Chang, CD; Coward, JK | 1 |
| Murphy, JT; Spence, KD | 1 |
| Knudsen, RC; Yall, I | 1 |
| Lautenberger, JA; Linn, S | 1 |
| Hildesheim, J; Hildesheim, R; Lederer, E; Yon, J | 1 |
| Blanchard, P; Farrugia, G; Hildesheim, J; Hildesheim, R; Michelot, R | 1 |
| Cartenì-Farina, M; Galletti, P; Servillo, L; Zappia, V | 1 |
| Grant, ME; Hogenkamp, HP; Tkachuck, RD | 1 |
| Coulter, AW; Lombardini, JB; Talalay, P | 1 |
| Hildesheim, J; Hildesheim, R; Lederer, E | 2 |
| Baudry, M; Chast, F; Schwartz, JC | 1 |
| Coward, JK; Slisz, EP | 1 |
| Coward, JK; Wu, FY | 1 |
| Himwich, HE; Lin, RL; Narasimhachari, N | 1 |
| Pendleton, RG; Snow, IB | 1 |
| Finkelstein, JD; Harris, B | 1 |
| Borchardt, RT; Huber, JA; Wu, YS | 1 |
| Lombardini, JB; Talalay, P | 1 |
| Coward, JK; Sweet, WD | 1 |
| Coward, JK; D'Urso-Scott, M; Sweet, WD | 1 |
| Chen, SS; Duerre, JA; Walgate, JH | 1 |
| Glazer, RI; Hartman, KD | 1 |
| Chiang, PK; Morita, Y; Siraganian, RP | 1 |
| Morita, Y; Siraganian, RP | 1 |
| Ahl, R | 1 |
| Adams, JK; Allan, RG; Cooper, IA; Woodcock, DM | 1 |
| Hoffman, RM | 1 |
| Bardin, CW; Gagnon, C | 1 |
| Fonlupt, P; Pacheco, H; Rey, C | 1 |
| Robert-Géro, M; Vedel, M | 1 |
| Pike, MC; Snyderman, R | 2 |
| Borchardt, RT; Pugh, CS | 1 |
| Mizel, D; Pick, E | 1 |
| Boss, GR; Pilz, RB | 1 |
| Cooper, AJ | 1 |
| Della Ragione, F; Pegg, AE | 1 |
| Porta, R; Schatz, RA; Sellinger, OZ; Wilens, TE | 1 |
| Rutledge, CO; Samet, MK | 1 |
| Barber, JR; Clarke, S | 1 |
| Carson, DA; Kamatani, N; Willis, EH | 1 |
| Falletta, JM; Hershfield, MS; Kinney, TR; Koller, CA; Kredich, NM; Kurtzberg, J; Mitchell, BS | 1 |
| Helland, S; Ueland, PM | 2 |
| Gregor, P; Schatz, RA; Sellinger, OZ; Tatter, SB; Wilens, TE | 1 |
| Broch, OJ; Helland, S; Schanche, JS; Ueland, PM | 1 |
| Chiang, PK | 1 |
| Ueland, PM | 1 |
| Fox, IH; Herring, C; Palella, TD; Thompson, D | 1 |
| Chabannes, B; Gharib, A; Pachéco, H; Sarda, N | 1 |
| Pusch, R; Reddington, M | 1 |
| Kendall, HE; Kredich, NM; Spence, FJ | 1 |
| Fox, IH; Palella, TD; Schatz, RA; Wilens, TE | 1 |
| Braun, J; Rosen, FS; Unanue, ER | 1 |
| Chabannes, B; Cronenberger, L; Gharib, A; Pacheco, H; Sarda, N | 1 |
| Eloranta, TO; Kajander, EO; Raina, AM | 1 |
| Schanche, JS; Schanche, T; Ueland, PM | 1 |
| Schatz, RA; Sellinger, OZ; Wilens, TE | 2 |
| Aarbakke, J; Ueland, PM | 1 |
| Bardenheuer, H; Schrader, J; Schütz, W | 1 |
| Bynum, JW | 1 |
| Cornatzer, WE; Duerre, JA; Hoffman, DR; Marion, DW | 1 |
| Hoffman, JL | 1 |
| Buc-Calderon, P; Tinton, S | 2 |
| De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Linder, M; Scholtissek, C; Woyciniuk, P | 1 |
| Bergmann, S; Lehmann, V; Ratter, F; Schiemann, S; Schulze-Osthoff, K; Shatrov, V | 1 |
| Kroll, K; Martin, GV | 1 |
| Chen, H; McLennan, AG | 1 |
| Fredholm, BB; Lindström, K; Lloyd, HG | 1 |
| Sciotti, VM; Van Wylen, DG | 1 |
| Aarbakke, J; Endresen, PC; Kildalsen, H; Loennechen, T | 1 |
| Kamen, BA; Quinn, CT | 1 |
| Deussen, A; Flesche, CW; Loncar, R | 1 |
| Aletta, JM; Cimato, TR; Ettinger, MJ; Zhou, X | 1 |
| Blayac, JP; Brunschwig, C; Chapal, J; Hillaire-Buys, D; Janbon, C; Loubatières-Mariani, MM; Petit, P; Quéré, I | 1 |
| Ashizawa, K; Miyamoto, M; Tsuzuki, Y | 1 |
| Andersson, A; Hultberg, B; Isaksson, A | 1 |
| Abbracchio, MP; Camurri, A; Ceruti, S; Falzano, L; Fiorentini, C; Frank, C; Giammarioli, AM; Malorni, W; Rufini, S | 1 |
| Deussen, A | 2 |
| Ballard, G; Harrington, EO; Newton, J; Rounds, S; Smeglin, A | 1 |
| Müller, T | 1 |
| Chango, A; James, SJ; Melnyk, S; Pogribna, M; Pogribny, I; Yi, P | 1 |
| Ashihara, H; Crozier, A; Kato, A; Koshiishi, C; Yama, S | 1 |
| Bellas, RE; Harrington, EO; Marcus, C; Newton, J; Rounds, S; Sheahan, KL | 1 |
| Delabar, U; Kloor, D; Luippold, G; Mühlbauer, B; Osswald, H | 1 |
| Chen, YF; Li, PL; Zou, AP | 1 |
| Wnuk, SF | 1 |
| Elovaara, I; Jaakkola, O; Janatuinen, T; Jokela, H; Knuuti, J; Laakso, J; Laaksonen, R; Lehtimäki, T; Nuutila, P; Punnonen, K; Raitakari, O; Saikku, P; Salminen, K; Vesalainen, R | 1 |
| Blom, HJ; Boers, GH; Riksen, NP; Rongen, GA; Russel, FG; Smits, P | 1 |
| SAKAMI, W; STEVENS, A | 1 |
| CANTONI, GL; DE LA HABA, G | 1 |
| Garber, M; Hai, CM; Harrington, EO; Hirase, T; Lu, Q; Newton, J; Rounds, S | 1 |
| Selley, ML | 1 |
| Harrington, EO; Morin, N; Newton, J; Rounds, S | 1 |
| Barve, S; Chen, T; Kang, YJ; McClain, CJ; Song, Z; Uriarte, S; Wang, L; Zhou, Z | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA | 1 |
| Blom, HJ; Boers, GH; Riksen, NP; Rongen, GA; Smits, P; van den Broek, PH | 1 |
| Cutler, P; Gaylor, DW; James, SJ; Janak, L; Jernigan, S; Melnyk, S; Neubrander, JA | 1 |
| Cacciapuoti, G; Concilio, L; Forte, S; Graziano, G; Merlino, A; Moretti, MA; Porcelli, M | 1 |
| Hultberg, B | 1 |
| Charlton, CG; Chen, H; Lee, ES; Soliman, KF | 1 |
| Afman, LA; Blom, HJ; Brouns, MR; Drittij, MJ; van Straaten, HW | 1 |
| Blom, HJ; Boers, GH; Riksen, NP; Rongen, GA; Smits, P | 1 |
| Deussen, A; Loncar, R; Pexa, A; Stehr, SN | 1 |
| Andersson, A; Hultberg, B; Hultberg, M; Isaksson, A | 1 |
| Chambers, MG; Mason, RM; Mistry, D | 1 |
| Boerma, M; Hauer-Jensen, M; Joseph, J; Kennedy, RH; Melchert, RB; Owings, R | 1 |
| Karasu, E; Ozdem, S; Sadan, G; Tasatargil, A | 1 |
| Daub, E; Honek, JF; Sampson, PB; Vaughan, MD | 1 |
| Hermes, M; Kloor, D; Osswald, H | 1 |
| Bea, F; Blessing, E; Isermann, B; Katus, HA; Kreuzer, J; Pedal, I; Preusch, MR; Rosenfeld, ME; Yang, SH | 1 |
| Cacciapuoti, G; Manna, C; Napoli, D; Porcelli, M; Zappia, V | 1 |
| Ioerger, TR; Kuppan, G; Owen, JL; Reddy, MC; Sacchettini, JC; Shetty, ND | 1 |
| Alibegovic, AA; Dela, F; Højbjerre, L; Sonne, MP; Stallknecht, B; Vaag, A | 1 |
| Benkhalifa, M; Cohen-Bacrie, P; Ménézo, Y; Montjean, D | 1 |
| Hu, ML; Lin, HC; Liu, CL; Yang, CM | 1 |
| Bleie, Ø; Igland, J; Nordrehaug, JE; Nygård, OK; Refsum, H; Strand, E; Ueland, PM; Vollset, SE | 1 |
| Lu, Q; Rounds, S | 1 |
| Alibegovic, AC; Dela, F; Højbjerre, L; Nielsen, LB; Sonne, MP; Stallknecht, B; Vaag, AA | 1 |
| Hahn, NE; Krijnen, PA; Meischl, C; Musters, RJ; Niessen, HW; Rauwerda, JA; Sipkens, JA; Smith, DE; Stehouwer, CD; van Hinsbergh, VW; Wassink, M | 1 |
| Blom, HJ; Hahn, NE; Krijnen, PA; Lougheed, SM; Niessen, HW; Rauwerda, JA; Sipkens, JA; Stehouwer, CD; van Hinsbergh, VW | 1 |
| Chan, K; Kam, A; Li, GQ; Li, KM; Nammi, S; Razmovski-Naumovski, V | 2 |
| Hamada, K; Hudec, R; Mikoshiba, K | 1 |
| Chen, YM; Chiang, EP; Lin, WL; Lin, YJ; Tang, FY; Wang, YC | 1 |
| Nian, S; Tan, X; Wang, G; Wang, P | 1 |
| Converso, A; Fraley, ME; Garbaccio, RM; Hartingh, T; Hartman, GD; Huang, SY; Majercak, JM; McCampbell, A; Na, SJ; Ray, WJ; Savage, MJ; White, R; Wolffe, C; Yeh, S; Yu, Y; Zhang, R | 1 |
| Chae, SW; Park, SW; Song, JJ; Yadav, MK | 1 |
| Imiolczyk, B; Jaskolski, M; Manszewski, T; Singh, K | 1 |
| Chan, K; Kam, A; Razmovski-Naumovski, V; Troung, J; Zhou, X | 1 |
| Bonatti, S; Bruzzese, L; Cuisset, T; Deharo, P; Fenouillet, E; Fromonot, J; Guieu, R; Mottola, G; Quilici, J; Ruf, J | 1 |
| Bruzzese, L; Condo, J; Deharo, P; Durand-Gorde, JM; Fenouillet, E; Fromonot, J; Guieu, R; Kipson, N; Mottola, G; Ruf, J | 1 |
| Huang, YP; Li, C; Tang, J; Yi, M; Zhang, Y; Zhao, S | 1 |
| Brzezinski, K | 1 |
13 review(s) available for homocysteine and adenosine
| Article | Year |
|---|---|
Formation, functions and regulatory importance of S-adenosyl-L-methionine.
Topics: Adenosine; Adenosine Triphosphate; Alkanes; Alkenes; Alkynes; Amino Acids; Animals; Antineoplastic Agents; Binding Sites; Carbon Isotopes; Carboxylic Acids; Cyclopentanes; Escherichia coli; Homocysteine; Homoserine; Kinetics; Liver; Methionine; Methylation; Mice; Neoplasms, Experimental; Rats; Spleen; Transferases; Tritium; Yeasts | 1970 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
The possible role of protein-carboxyl methylation in sperm motility and capacitation.
Topics: Adenine; Adenosine; Animals; Dyneins; Homocysteine; Humans; Infertility, Male; Male; Methylation; Mitochondria; Protein Methyltransferases; Protein O-Methyltransferase; Sperm Capacitation; Sperm Motility; Spermatogenesis; Spermatozoa; Testis | 1982 |
Biochemistry of sulfur-containing amino acids.
Topics: Adenosine; Amino Acid Metabolism, Inborn Errors; Animals; Cysteine; Deoxyadenosines; Homocysteine; Humans; Methionine; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; S-Adenosylmethionine; Structure-Activity Relationship; Sulfur; Sulfurtransferases; Thionucleosides; Thiosulfate Sulfurtransferase | 1983 |
Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Catalysis; Chemical Phenomena; Chemistry, Physical; Genes; Homocysteine; Humans; Hydrolases; Kinetics; Protein Binding; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; S-Adenosylhomocysteine; Substrate Specificity; Tubercidin | 1982 |
A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities.
Topics: Acute Disease; Adenosine; Biopterins; Chronic Disease; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Nervous System Diseases; Nucleic Acid Synthesis Inhibitors | 1996 |
Non-dopaminergic drug treatment of Parkinson's disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Body Weight; Cholinergic Antagonists; Homocysteine; Humans; Levodopa; Methionine; N-Methylaspartate; Parkinson Disease; Piperidines; Serotonin Receptor Agonists | 2001 |
Targeting "hydrolytic" activity of the S-adenosyl-L-homocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Coronary Disease; Drug Design; Enzyme Inhibitors; Homocysteine; Humans; Hydrolases; Hydrolysis; Risk Factors; Structure-Activity Relationship | 2001 |
Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia.
Topics: Adenosine; Cardiovascular Diseases; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Receptors, Purinergic P1; S-Adenosylhomocysteine | 2003 |
Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia.
Topics: Adenosine; Animals; Homocysteine; Humans; Hyperhomocysteinemia; Receptors, Purinergic P1 | 2005 |
Effects of homocysteine on vascular and tissue adenosine: a stake in homocysteine pathogenicity?
Topics: Adenosine; Animals; Homocysteine; Humans; Hypoxia; Ischemia; Organ Specificity | 2005 |
Focal adhesion kinase and endothelial cell apoptosis.
Topics: Adenosine; Animals; Anoikis; Apoptosis; Cardiovascular Diseases; Endothelial Cells; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Homocysteine; Humans; Monomeric GTP-Binding Proteins; Signal Transduction | 2012 |
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Amino Acid Motifs; Animals; Crystallography, X-Ray; Databases, Protein; Homocysteine; Humans; Ligands; Methylation; Molecular Conformation; NAD; Nucleotides; Protein Binding; Protein Domains; Protein Folding; Software | 2020 |
2 trial(s) available for homocysteine and adenosine
| Article | Year |
|---|---|
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
Coronary blood flow in patients with stable coronary artery disease treated long term with folic acid and vitamin B12.
Topics: Acetylcholine; Adenosine; Aged; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Double-Blind Method; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Laser-Doppler Flowmetry; Male; Middle Aged; Time Factors; Vitamin B 12; Vitamin B 6 | 2011 |
200 other study(ies) available for homocysteine and adenosine
| Article | Year |
|---|---|
Decreased rate of S-adenosyl-L-homocysteine metabolism: an early event related to transformation in cells infected with Rous sarcoma virus.
Topics: Adenosine; Adenosine Deaminase; Amino Acid Oxidoreductases; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Homocysteine; Hydrolases; Methylation; Neoplasm Proteins; Proteins; S-Adenosylhomocysteine; Tumor Virus Infections | 1977 |
Inhibition of virus-induced cell transformation by synthetic analogues of S-adenosyl homocysteine.
Topics: Adenosine; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Fibroblasts; Homocysteine; S-Adenosylhomocysteine; Time Factors; Virus Replication | 1975 |
An adenosine 3':5'-monophosphate adenosine-binding protein from mouse liver. Association with S-adenosylhomocysteinase activity.
Topics: Adenosine; Animals; Carrier Proteins; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Homocysteine; Hydrolases; Hydrolysis; Liver; Mice; S-Adenosylhomocysteine | 1978 |
S-adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Cell Division; Cell Line; Homocysteine; Humans; Lactones; Lymphocytes; Methylation; Phosphotransferases; S-Adenosylhomocysteine | 1979 |
Cyclic AMP-adenosine binding protein/S-adenosylhomocysteinase from mouse liver. A fraction of adenosine bound is converted to adenine.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Carrier Proteins; Chromatography, Gel; Chromatography, Thin Layer; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Homocysteine; Hydrolases; Hydrolysis; In Vitro Techniques; Inosine; Liver; Mice; Protein Denaturation; Ribose; S-Adenosylhomocysteine | 1979 |
Potentiation by homocysteine of adenosine-stimulated elevation of cellular adnosine 3',5'-monophosphate.
Topics: Adenosine; Animals; Cyclic AMP; Drug Synergism; Homocysteine; In Vitro Techniques; Lymphocytes; Mice; Prostaglandins E | 1979 |
S-adenosyl-L-homocysteine as a stimulator of viral RNA synthesis by two distinct cytoplasmic polyhedrosis viruses.
Topics: Adenosine; Cell-Free System; Homocysteine; Insect Viruses; Methylation; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Stimulation, Chemical | 1978 |
Inhibition of methylation by adenosine in adenosine deaminase-inhibited, phytohemagglutinin-stimulated human lymphocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; DNA; Homocysteine; Humans; Lymphocyte Activation; Methylation; Nucleoside Deaminases; Phytohemagglutinins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1979 |
Inhibition of immune cell function by adenosine: biochemical studies.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Animals; Cytotoxicity, Immunologic; Homocysteine; Imidazoles; Lymphocytes; Methionine; Mice; S-Adenosylmethionine; Theophylline; Uridine | 1979 |
Role of S-adenosylhomocysteine in adenosinemediated toxicity in cultured mouse T lymphoma cells.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Cell Line; DNA; DNA (Cytosine-5-)-Methyltransferases; Homocysteine; Homocystine; Lymphoma; S-Adenosylhomocysteine | 1977 |
Differential inhibition of mammalian aminopropyltransferase activities.
Topics: Adenosine; Animals; Diamines; Ethionine; Homocysteine; Male; Prostate; Rats; S-Adenosylhomocysteine; Spermidine Synthase; Spermine Synthase; Thionucleosides; Transferases | 1978 |
Protein methylation in animal cells. II. Inhibition of S-adenosyl-L-methionine:protein(arginine) N-methyltransferase by analogs of S-adenosyl-L-homocysteine.
Topics: Adenosine; Binding Sites; Homocysteine; Isomerism; Kinetics; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; S-Adenosylhomocysteine; Structure-Activity Relationship | 1978 |
A sensitive isotopic assay method for S-adenosylhomocysteine hydrolase. Some properties of the enzyme from rat liver.
Topics: Adenosine; Animals; Carbon Radioisotopes; Electrophoresis, Paper; Female; Homocysteine; Hydrolases; Isotope Labeling; Kinetics; Liver; Rats | 1976 |
Tetrahydrofolic acid: an inhibitor of the methyltetrahydrofolic acid-mediated methylation of indolethylamines.
Topics: Adenosine; Animals; Binding, Competitive; Bufotenin; Ethylamines; Homocysteine; Indoles; Lung; Methylation; Methyltransferases; N,N-Dimethyltryptamine; Rabbits; S-Adenosylmethionine; Serotonin; Tetrahydrofolates | 1975 |
The S-n-propyl analogue of S-adenosylmethionine.
Topics: Acetates; Adenosine; Guanidines; Histamine; Homocysteine; Methyltransferases; S-Adenosylmethionine; Saccharomyces cerevisiae; Serotonin; Structure-Activity Relationship; Sulfides | 1975 |
Regulation of cyclopropane fatty acid biosynthesis by variations in enzyme activities.
Topics: Adenosine; Cell Division; Cyclopropanes; Fatty Acids; Homocysteine; Lactobacillus; Methyltransferases; N-Glycosyl Hydrolases; S-Adenosylmethionine; Time Factors | 1975 |
S-adenosylhomocysteine metabolism in various species.
Topics: Adenosine; Animals; Bacteria; Chickens; Dogs; Fungi; Homocysteine; Kinetics; N-Glycosyl Hydrolases; Organ Specificity; Plants; Rabbits; Rats; Species Specificity | 1975 |
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine.
Topics: Adenosine; Adrenal Medulla; Animals; Binding Sites; Brain; Catechol O-Methyltransferase Inhibitors; Cattle; Deoxy Sugars; Guinea Pigs; Homocysteine; Liver; Magnetic Resonance Spectroscopy; Male; Methyltransferases; Phenylethanolamine N-Methyltransferase; Pineal Gland; Rats; S-Adenosylmethionine; Serotonin | 1975 |
Adenine nucleosides in solution: circular dichroism studies and base conformation.
Topics: Adenosine; Adenosine Monophosphate; Anti-Bacterial Agents; Circular Dichroism; Homocysteine; Molecular Conformation; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1975 |
Noninvasive assessment of regional cardiac adenosine using positron emission tomography.
Topics: Adenosine; Animals; Carbon Radioisotopes; Dogs; Energy Metabolism; Homocysteine; Myocardial Ischemia; Tissue Distribution; Tomography, Emission-Computed | 1992 |
Analysis of the inhibition of commitment of murine erythroleukemia (MEL) cells to terminal maturation by N6-methyladenosine.
Topics: Adenine; Adenosine; Animals; Cell Differentiation; Cell Division; Cell Survival; Deoxyadenosines; Dimethyl Sulfoxide; Hemoglobins; Homocysteine; Leukemia, Erythroblastic, Acute; Methionine; Mice; RNA, Messenger; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
S-adenosylhomocysteine levels are not involved in the spasmolytic activity of 3-deazaadenosine in guinea-pig lung parenchyma.
Topics: Adenosine; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Homocysteine; In Vitro Techniques; Lung; Male; Parasympatholytics; S-Adenosylhomocysteine; SRS-A; Tubercidin | 1991 |
Elevation of cyclic AMP levels in HL-60 cells accumulated in G1 or G2 by transmethylation inhibitors.
Topics: Adenosine; Cell Division; Cell Line; Cyclic AMP; Flow Cytometry; G1 Phase; G2 Phase; Homocysteine; Humans; Leukemia; Methyltransferases; Tubercidin | 1991 |
Homocysteine and the methotrexate toxicity in trisomy 21.
Topics: Adenosine; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methotrexate | 1991 |
Inhibitors of membrane lipid metabolism enhance complement-mediated nucleated cell killing through distinct mechanisms.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acylation; Adenine; Adenosine; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Complement C9; Complement Membrane Attack Complex; Complement System Proteins; Cytotoxicity, Immunologic; Flow Cytometry; Homocysteine; Immunosuppressive Agents; L-Lactate Dehydrogenase; Membrane Lipids; Methylation; Mice; Thimerosal | 1991 |
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.
Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured | 1990 |
Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth.
Topics: Adenosine; Animals; Cell Division; DNA, Neoplasm; Homocysteine; Leukemia L1210; Methylation; Polyamines; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 1990 |
Blockade by methylation inhibitors of the anaphylactic response of guinea-pig lung strips.
Topics: Adenosine; Airway Resistance; Anaphylaxis; Animals; Female; Guinea Pigs; Histamine Release; Homocysteine; In Vitro Techniques; Lung; Male; Methylation; Ovalbumin; Thromboxane B2; Tubercidin | 1987 |
Effects of 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine on the metabolism of S-adenosylhomocysteine in mouse L929 cells.
Topics: Adenosine; Adenosine Kinase; Adenosylhomocysteinase; Animals; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Homocysteine; Hydrolases; Mice; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1988 |
S-adenosylmethionine, S-adenosylhomocysteine and adenosine system. Age-dependent availability in rat brain.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aging; Animals; Brain; Homocysteine; In Vitro Techniques; Kinetics; Male; Membranes; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Antiviral Agents; Cell Survival; DNA, Neoplasm; Drug Synergism; Homocysteine; Humans; Hydrolases; In Vitro Techniques; Neoplasm Proteins; RNA, Neoplasm; Tumor Cells, Cultured | 1989 |
Relationship between intracellular concentration of S-adenosylhomocysteine and inhibition of vaccinia virus replication and inhibition of murine L-929 cell growth.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Cell Division; Chromatography, High Pressure Liquid; Homocysteine; Hydrolases; L Cells; Methylation; Mice; S-Adenosylhomocysteine; Time Factors; Vaccinia virus; Virus Replication | 1989 |
Contribution of S-adenosylhomocysteine to cardiac adenosine formation.
Topics: Adenine; Adenosine; Animals; Guinea Pigs; Heart; Homocysteine; In Vitro Techniques; Kinetics; Models, Theoretical; Myocardium; Perfusion; S-Adenosylhomocysteine | 1989 |
Elucidation of the mechanism by which homocysteine potentiates the anti-vaccinia virus effects of the S-adenosylhomocysteine hydrolase inhibitor 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Drug Synergism; Homocysteine; Hydrolases; L Cells; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Vaccinia virus | 1989 |
Inhibition of phosphoinositide metabolism in human polymorphonuclear leukocytes by S-adenosylhomocysteine.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Homocysteine; Humans; In Vitro Techniques; Kinetics; Neutrophils; Phosphatidylinositols; S-Adenosylhomocysteine; Type C Phospholipases | 1988 |
Differential effects on growth, homocysteine, and related compounds of two inhibitors of S-adenosylhomocysteine catabolism, 3-deazaadenosine, and 3-deazaaristeromycin, in C3H/10T1/2 cells.
Topics: Adenosine; Aminoglycosides; Animals; Anti-Bacterial Agents; Cell Division; Cell Line; Dose-Response Relationship, Drug; Glutathione; Glutathione Disulfide; Homocysteine; Mice; Mice, Inbred C3H; S-Adenosylhomocysteine; Tubercidin | 1989 |
Regulation of macrophage lysosomal secretion by adenosine, adenosine phosphate esters, and related structural analogues of adenosine.
Topics: Adenine; Adenine Nucleotides; Adenosine; Animals; Esterases; Homocysteine; Kinetics; Lysosomes; Macrophages; Male; Mice; Receptors, Cell Surface; Receptors, Purinergic; Secretory Rate; Structure-Activity Relationship; Theophylline; Tubercidin | 1985 |
Adenosine-homocysteine interactions in controlling cyclic AMP in rat brain cortical slices.
Topics: Adenosine; Animals; Brain Chemistry; Cerebral Cortex; Cyclic AMP; Homocysteine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine | 1985 |
Role of adenosine deaminase in human monocyte differentiation and tumor cell cytotoxicity.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Antibody-Dependent Cell Cytotoxicity; Carcinoma, Transitional Cell; Cell Differentiation; Cell Line; Cytotoxicity, Immunologic; Homocysteine; Humans; Lymphokines; Macrophage Activation; Monocytes; Nucleoside Deaminases; Phagocytosis; Superoxides; Urinary Bladder Neoplasms | 1985 |
The total serum homocysteine as an indicator of vitamin B12 and folate status.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Aged; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Humans; Hydrolases; Infant; Male; Middle Aged; Reference Standards; Tritium; Vitamin B 12 | 1988 |
Differential metabolic response of rat liver, kidney and spleen to ethionine exposure. S-adenosylamino acids, homocysteine and reduced glutathione in tissues.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Ethionine; Glutathione; Homocysteine; Kidney; Liver; Male; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Spleen; Time Factors | 1988 |
Inhibition of methyltransferase reduces the turnover of acetylcholine receptors.
Topics: Adenine; Adenosine; Animals; Dose-Response Relationship, Drug; Endocytosis; Homocysteine; In Vitro Techniques; Methionine; Methyltransferases; Muscles; Myasthenia Gravis; Phospholipids; Rats; Receptors, Nicotinic | 1988 |
Implication of protein carboxymethylation in retinal pigment epithelial cell chemotaxis.
Topics: Adenine; Adenosine; Chemotaxis; Eye Proteins; Fibronectins; Homocysteine; Humans; Hydrolysis; Methanol; Pigment Epithelium of Eye; Platelet-Derived Growth Factor; Protein Methyltransferases; Protein O-Methyltransferase | 1988 |
Formation of S-adenosylhomocysteine in the heart. I: An index of free intracellular adenosine.
Topics: Adenosine; Animals; Guinea Pigs; Homocysteine; Intracellular Fluid; Myocardium; S-Adenosylhomocysteine | 1988 |
Formation of S-adenosylhomocysteine in the heart. II: A sensitive index for regional myocardial underperfusion.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Coronary Circulation; Coronary Disease; Dogs; Endocardium; Homocysteine; Hydrogen-Ion Concentration; Hydrolases; Myocardium; Perfusion; S-Adenosylhomocysteine | 1988 |
The transmethylation pathway as a source for adenosine in the isolated guinea-pig heart.
Topics: Adenosine; Animals; Guinea Pigs; Homocysteine; In Vitro Techniques; Methylation; Myocardium; Oxygen; Perfusion; S-Adenosylhomocysteine | 1988 |
4'-Thioadenosine as a novel inhibitor of S-adenosylhomocysteine hydrolase and an inducer for the differentiation of HL-60 human leukemia cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Differentiation; Cell Line; Chromatography, High Pressure Liquid; Homocysteine; Humans; Hydrolases; Leukemia, Myeloid, Acute; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1986 |
Inhibitor of 2', 5'-oligoadenylate synthetase induced in human T lymphoblastoid cell line treated with deoxyadenosine, deoxycoformycin and interferon.
Topics: 2',5'-Oligoadenylate Synthetase; Adenosine; Cell Line; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; Enzyme Induction; Homocysteine; Humans; Interferon Type I; Pentostatin; Ribonucleosides; T-Lymphocytes; Vidarabine | 1986 |
Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools.
Topics: Adenosine; Animals; Cells, Cultured; Drug Resistance; Homocysteine; Kinetics; Lymphoma; Methionine; Methionine Adenosyltransferase; Mice; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine | 1986 |
Adenosine in cerebral homeostatic role: appraisal through actions of homocysteine, colchicine, and dipyridamole.
Topics: Adenine; Adenosine; Animals; Cerebral Cortex; Colchicine; Dipyridamole; Glutamates; Guinea Pigs; Homeostasis; Homocysteine; Hypoxia; Potassium; Rats | 1986 |
Possible involvement of the S-adenosyl-L-homocysteine metabolites, adenosine and L-homocysteine, in sleep in rats.
Topics: Adenosine; Animals; Electroencephalography; Homocysteine; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; Sleep Stages; Sleep, REM; Time Factors | 1986 |
Disposition of homocysteine and S-3-deazaadenosylhomocysteine in cells exposed to 3-deazaadenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Fibroblasts; Homocysteine; Hydrolases; Liver; Mice; Neoplasms, Experimental; Protein Binding; Rats; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1986 |
Carboxyl methylation of human erythrocyte band 3 in intact cells. Relation to anion transport activity.
Topics: Adenosine; Anion Exchange Protein 1, Erythrocyte; Anions; Biological Transport; Cycloleucine; Erythrocytes; Homocysteine; Humans; Methylation; Phosphates | 1986 |
Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Adenosylhomocysteinase; Animals; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Homocysteine; Hydrolases; In Vitro Techniques; Liver; Methionine; Rats; S-Adenosylhomocysteine | 1986 |
Inhibition of macrophage phagocytosis by methylation inhibitors. Lack of correlation of protein carboxymethylation and phospholipid methylation with phagocytosis.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Deoxyadenosines; Homocysteine; Kinetics; Macrophages; Methylation; Mice; Phagocytosis; Phospholipids; Proteins; Vidarabine | 1985 |
Inhibition of antibody production by 2-chloroadenosine.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; DNA Replication; Homocysteine; Immunosuppressive Agents; Lymphocyte Activation; Male; Methylation; Mice; S-Adenosylmethionine | 1985 |
An analysis of multiple mechanisms of adenosine toxicity in baby hamster kidney cells.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cell Adhesion; Cell Line; Coformycin; Drug Resistance; Drug Synergism; Guinea Pigs; Homocysteine; Kidney; Nucleotides; Pentostatin; Ribonucleotide Reductases; S-Adenosylhomocysteine; Uridine | 1985 |
Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells.
Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; Homocysteine; Humans; Kinetics; Methylation; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; T-Lymphocytes; Thionucleosides | 1985 |
Salvage of 5'-deoxy-5'-methylthioadenosine and L-homocysteine into methionine in cells cultured in a methionine-free medium: a study of "methionine-dependence".
Topics: Adenosine; Animals; Cell Division; Cell Line; Cricetinae; Culture Media; Deoxyadenosines; Homocysteine; Humans; Methionine; Thionucleosides | 1986 |
Myocardial S-adenosylhomocysteine hydrolase is important for adenosine production during normoxia.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Coronary Disease; Homocysteine; Hydrolases; In Vitro Techniques; Kinetics; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains | 1985 |
Transient methylation of dolichyl oligosaccharides is an obligatory step in halobacterial sulfated glycoprotein biosynthesis.
Topics: 3-O-Methylglucose; Adenosine; Bacterial Proteins; Clusterin; Glycoproteins; Halobacterium; Homocysteine; Methylation; Methylglucosides; Molecular Chaperones; Polyisoprenyl Phosphate Oligosaccharides; Polyisoprenyl Phosphate Sugars | 1985 |
Glutathione changes occurring after S-adenosylhomocysteine hydrolase inhibition.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antigens, Neoplasm; Cells, Cultured; Cystathionine; Glutathione; Homocysteine; Hydrolases; Leukemia L5178; Liver; Male; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; Time Factors | 1985 |
An early effect of the S component of staphylococcal leukocidin on methylation of phospholipid in various leukocytes.
Topics: Adenine; Adenosine; Animals; Cell Survival; Enzyme Activation; Homocysteine; Leukocidins; Membrane Lipids; Methylation; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Rabbits; Staphylococcus | 1985 |
Methylation of myelin basic protein by enzymes from rat brain.
Topics: Adenosine; Aging; Animals; Arginine; Brain; Carbon Radioisotopes; Cell Nucleus; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cytoplasm; Homocysteine; Methylation; Methyltransferases; Microsomes; Mitochondria; Myelin Basic Protein; Myelin Sheath; Rats; Ribosomes; S-Adenosylmethionine; Time Factors; Tritium; Ultrafiltration | 1974 |
The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B.
Topics: Adenosine; Adenosine Triphosphatases; Carbon Isotopes; Chromatography, DEAE-Cellulose; Coliphages; Deoxyribonucleases; DNA, Bacterial; DNA, Viral; Endonucleases; Enzyme Activation; Escherichia coli; Ethionine; Homocysteine; Kinetics; Phosphorus Isotopes; S-Adenosylmethionine; Sulfides | 1972 |
Competing methyltransferase systems.
Topics: Adenosine; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; Glycine; Homocysteine; Kidney; Liver; Liver Neoplasms; Methylation; Methyltransferases; Mice; Molecular Weight; Pancreas; Rabbits; Rats; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine | 1972 |
Effects of carcinogens and other agents on histone methylation by a histone arginine methyltransferase purified from rat liver cytoplasm.
Topics: Acridines; Adenine; Adenosine; Animals; Arginine; Azo Compounds; Carbon Radioisotopes; Carcinogens; Cytoplasm; Dimethylformamide; Ethidium; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Male; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
Effects of carcinogens and other agents on histone methylation in rat liver nuclei by endogenous histone lysine methyltransferase.
Topics: Adenosine; Animals; Azo Compounds; Benz(a)Anthracenes; Carbon Radioisotopes; Carcinogens; Cell Nucleus; Dimethylformamide; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Lysine; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.
Topics: Adenosine; Alcohol Oxidoreductases; Ammonium Sulfate; Animals; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Drug Stability; Flavin-Adenine Dinucleotide; Folic Acid; Formaldehyde; Homocysteine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Liver; NAD; NADP; Rats; S-Adenosylmethionine; Spectrophotometry; Swine; Vitamin K | 1971 |
Methionine metabolism in mammals: regulatory effects of S-adenosylhomocysteine.
Topics: Adenosine; Animals; Betaine; Chromatography, Gel; Cystathionine; Enzyme Activation; Homocysteine; Kinetics; Liver; Lyases; Methionine; Methyltransferases; Rats; Regression Analysis | 1974 |
Speculations about the binding sites of S-adenosyl-L-homocysteine and some of its synthetic analogues to histamine methyltransferase.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Carbon Radioisotopes; Gastric Mucosa; Histamine; Homocysteine; Methyltransferases; Structure-Activity Relationship; Swine | 1974 |
Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Inhibition of several methylases by S-tubercidinylhomocysteine.
Topics: Adenosine; Animals; Anti-Bacterial Agents; Catechol O-Methyltransferase Inhibitors; Homocysteine; Indoles; Kinetics; Liver; Lung; Methyltransferases; Pyrimidines; Pyrroles; Rabbits; Rats; Ribonucleosides; S-Adenosylmethionine; tRNA Methyltransferases | 1974 |
Transport of S-adenosylmethionine in Saccharomyces cerevisiae.
Topics: Adenosine; Azides; Biological Transport, Active; Carbon Isotopes; Chromatography, Paper; Culture Media; Cyanides; Cycloheximide; Diploidy; Ethionine; Genes; Genetics, Microbial; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Methionine; Mutation; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Temperature | 1972 |
Partial purification and characterization of S-adenosylhomocysteine hydrolase isolated from Saccharomyces cerevisiae.
Topics: Acetone; Adenine; Adenosine; Aminohydrolases; Carbon Isotopes; Cell-Free System; Chemical Precipitation; Chromatography, Gel; Chromatography, Paper; Dextrans; Homocysteine; Hydrolases; Hydroxyapatites; Nucleosides; Nucleotides; Ribonucleosides; Saccharomyces cerevisiae; Ultracentrifugation | 1972 |
The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B. I. Purification, subunit structure, and catalytic properties of the modification methylase.
Topics: Adenosine; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Coliphages; DNA; DNA, Bacterial; DNA, Viral; Drug Stability; Electrophoresis, Disc; Escherichia coli; Ethionine; Homocysteine; Hydrogen-Ion Concentration; Macromolecular Substances; Methyltransferases; Molecular Weight; Osmolar Concentration; S-Adenosylmethionine; Sodium Dodecyl Sulfate; Species Specificity; Sulfides; Tritium | 1972 |
The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B. II. Purification, subunit structure, and catalytic properties of the restriction endonuclease.
Topics: Adenosine; Adenosine Triphosphate; Catalysis; Cations, Divalent; Centrifugation, Density Gradient; Coliphages; DNA, Bacterial; DNA, Viral; Electrophoresis, Disc; Endonucleases; Escherichia coli; Ethionine; Exonucleases; Homocysteine; Kinetics; Macromolecular Substances; Molecular Weight; Phosphorus Isotopes; S-Adenosylmethionine; Sodium Dodecyl Sulfate; Sulfides; Tritium | 1972 |
[Inhibition of a t-RNA N 2 -guanine methyl transferase from rabbit liver by analogs of S-adenosyl homocysteine].
Topics: Adenosine; Animals; Escherichia coli; Guanine; Homocysteine; Kinetics; Liver; Methods; Methyltransferases; Rabbits; RNA, Transfer; Structure-Activity Relationship | 1972 |
Studies on synthetic inhibitors of t-RNA methyl transferases: analogs of S-adenosyl homocysteine.
Topics: Adenosine; Animals; Cysteamine; Cysteine; Escherichia coli; Homocysteine; Kinetics; Liver; Methylation; Propionates; Propylene Glycols; Rabbits; RNA, Transfer; tRNA Methyltransferases | 1973 |
A coupled spectrophotometric enzyme assay for methyltransferases.
Topics: Adenosine; Aminohydrolases; Animals; Aspergillus; Brain; Chromatography, Ion Exchange; Chromatography, Thin Layer; Electrophoresis, Paper; Evaluation Studies as Topic; Guinea Pigs; Histamine; Homocysteine; Kinetics; Methods; Methyltransferases; Microchemistry; Pineal Gland; S-Adenosylmethionine; Saccharomyces cerevisiae; Serotonin; Spectrophotometry, Ultraviolet; Temperature | 1974 |
Synthesis and properties of adenosyl- and methylepicobalamin.
Topics: Adenosine; Apoproteins; Carbon Isotopes; Carbon Radioisotopes; Circular Dichroism; Cobamides; Coenzymes; Escherichia coli; Homocysteine; Lactobacillus; Methyltransferases; Optical Rotatory Dispersion; Oxidation-Reduction; Ribonucleotide Reductases; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tetrahydrofolates | 1974 |
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. II. Aromatic amino acids.
Topics: Adenosine; Amino Acids; Animals; Electron Transport; Escherichia coli; Homocysteine; Homoserine; Hydrolysis; Liver; Malonates; Methionine; Molecular Conformation; Nitro Compounds; Phenylalanine; Rats; S-Adenosylmethionine; Structure-Activity Relationship; Transferases; Tyrosine; Valerates; Yeasts | 1974 |
[New syntheses of S-adenosyl homocysteine analogues, potential methyltransferase inhibitors].
Topics: Adenosine; Carboxy-Lyases; Chromatography, Thin Layer; Homocysteine; Mass Spectrometry; Methods; Methyltransferases; Nucleosides; S-Adenosylmethionine; Spectrum Analysis | 1972 |
Studies on S-adenosylhomocysteine inhibition of histamine transmethylation in brain.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Carbon Isotopes; Fluorometry; Guinea Pigs; Histamine; Homocysteine; Hot Temperature; Kinetics; Methylation; Methyltransferases; Protein Denaturation; Proteins; Pyrogallol; Time Factors; Tritium | 1973 |
Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Specificity of the S-adenosylhomocysteine binding site.
Topics: Adenosine; Animals; Binding Sites; Catechol O-Methyltransferase Inhibitors; Fluorine; Homocysteine; Kinetics; Liver; Methyltransferases; Protein Binding; Rats; Thermodynamics | 1973 |
A continuous spectrophotometric assay for catechol-O-methyltransferase.
Topics: Adenosine; Animals; Catechol O-Methyltransferase; Epinephrine; Homocysteine; Kinetics; Liver; Methods; Rats; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
Inhibition of indolethylamine-N-methyltransferase by S-adenosylhomocysteine.
Topics: Adenosine; Animals; Binding, Competitive; Chromatography, Gel; Chromatography, Thin Layer; Dialysis; Ethylamines; Homocysteine; Indoles; Kinetics; Lung; Methyltransferases; Protein Binding; Rabbits; S-Adenosylmethionine; Serotonin; Spectrometry, Fluorescence; Time Factors | 1973 |
The binding order of substrates to phenylethanolamine N-methyltransferase.
Topics: Adenosine; Adrenal Glands; Animals; Binding, Competitive; Carbon Radioisotopes; Chlorobenzenes; Cyclopropanes; Dose-Response Relationship, Drug; Homocysteine; In Vitro Techniques; Kinetics; Norepinephrine; Phenylethanolamine N-Methyltransferase; Propylamines; Protein Binding; Rabbits; S-Adenosylmethionine | 1973 |
Methionine metabolism in mammals: synthesis of S-adenosylhomocysteine in rat tissues.
Topics: Adenosine; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Paper; Cysteine; Dithiothreitol; Glucagon; Glutathione; Growth Hormone; Homocysteine; Hydrocortisone; Isotope Labeling; Liver; Male; Methionine; Organ Specificity; Rats; S-Adenosylmethionine; Thyroxine; Tritium | 1973 |
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 1. Modification of the amino acid portion of S-adenosylhomocysteine.
Topics: Adenosine; Adrenal Medulla; Animals; Binding Sites; Brain; Catechol O-Methyltransferase Inhibitors; Cattle; Computers; Guinea Pigs; Histamine; Homocysteine; Indoles; Kinetics; Liver; Male; Methyltransferases; Phenylethanolamine N-Methyltransferase; Pineal Gland; Protein Binding; Rats; S-Adenosylmethionine; Structure-Activity Relationship | 1974 |
Potential inhibitor of S-adenosylmethionine-dependent methyltransferases. 2. Modification of the base portion of S-adenosylhomocysteine.
Topics: Adenosine; Adrenal Medulla; Animals; Binding Sites; Brain; Catechol O-Methyltransferase Inhibitors; Cattle; Guinea Pigs; Histamine; Homocysteine; Indoles; Kinetics; Liver; Male; Methyltransferases; Phenylethanolamine N-Methyltransferase; Pineal Gland; Protein Binding; Rats; S-Adenosylmethionine; Structure-Activity Relationship | 1974 |
Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis and biological activity of homocysteine derivatives bridged to adenine.
Topics: Adenine; Adenosine; Catechol O-Methyltransferase Inhibitors; Chromatography, Ion Exchange; Chromatography, Thin Layer; Homocysteine; Methylation; Spectrum Analysis; Structure-Activity Relationship; Ultraviolet Rays | 1972 |
Inhibition of catechol-O-methyltransferase by S-adenosylhomocysteine and S-adenosylhomocysteine sulfoxide, a potential transition-state analog.
Topics: Adenosine; Animals; Carbon Isotopes; Catechol O-Methyltransferase Inhibitors; Chemical Phenomena; Chemistry; Homocysteine; Kinetics; Liver; Methylation; Methyltransferases; Rats; Structure-Activity Relationship; Sulfoxides | 1972 |
[Synthesis of methyl-transferase inhibitors: analogs of S-adenosyl homocysteine].
Topics: Adenosine; Chemical Phenomena; Chemistry; Homocysteine; Methyltransferases; Uridine | 1971 |
Oxidative deamination of sulfur amino acids by bacterial and snake venom L-amino acid oxidase.
Topics: Adenosine; Alanine; Amino Acid Oxidoreductases; Animals; Catalase; Cattle; Chromatography, Thin Layer; Cysteine; Cystine; Homocysteine; Homocystine; Hydrogen-Ion Concentration; Kinetics; Liver; Methionine; Models, Biological; Models, Structural; Oxygen Consumption; Proteus; S-Adenosylmethionine; Snakes; Species Specificity; Sulfides; Sulfur; Venoms | 1971 |
Evidence that the inhibitory effect of adenosine, but not cordycepin, on the methylation of nuclear RNA is mediated by S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Animals; Cell Nucleus; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Leukemia L1210; Methylation; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Effect of inhibitors of transmethylation on histamine release from human basophils.
Topics: Adenine; Adenosine; Basophils; Calcimycin; Histamine Release; Homocysteine; Humans; Immunoglobulin E; In Vitro Techniques; Methylation; Ribonucleosides; S-Adenosylmethionine; Tubercidin | 1981 |
Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
Topics: Adenine; Adenosine; Animals; Basophils; Female; Histamine Release; Homocysteine; Immunoglobulin E; Leukemia; Mast Cells; Methylation; Mice; Rabbits; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1981 |
Effect of inhibitors of methylation on early and late interferon synthesis in bovine kidney cell cultures.
Topics: Adenine; Adenosine; Animals; Cattle; Cells, Cultured; Cycloheximide; Cycloleucine; Homocysteine; Interferons; Methylation; Newcastle disease virus; Poly I-C; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; Cytosine; Deoxyadenosines; DNA; DNA Replication; Ethionine; Homocysteine; Humans; Methylation; Thionucleosides; Tubercidin | 1983 |
In vitro and in vivo binding of S-adenosyl-L-homocysteine to membranes from rat cerebral cortex.
Topics: Adenosine; Animals; Brain Chemistry; Calcium; Cell Membrane; Cerebral Cortex; Chromatography, High Pressure Liquid; Homocysteine; Magnesium; Male; Protein Binding; Rats; Receptors, Neurotransmitter; S-Adenosylhomocysteine; Time Factors | 1981 |
Comparative effect of S-adenosyl-homocysteine (SAH) and Sinefungin on tRNA-base methylation in whole cells and in vitro.
Topics: Adenine; Adenosine; Animals; Antifungal Agents; Avian Sarcoma Viruses; Cell Transformation, Viral; Escherichia coli; Guanine; Homocysteine; Methylation; RNA, Transfer; S-Adenosylhomocysteine | 1981 |
Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages.
Topics: Adenosine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Guinea Pigs; Homocysteine; Isoproterenol; Kinetics; Methylation; Receptors, Cell Surface; Receptors, Formyl Peptide; S-Adenosylmethionine; Superoxides; Theophylline | 1982 |
Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation.
Topics: Adenosine; Chemical Phenomena; Chemistry; DNA-Directed RNA Polymerases; Homocysteine; Kinetics; Methyltransferases; Nucleotidyltransferases; RNA, Viral; S-Adenosylhomocysteine; Structure-Activity Relationship; Vaccinia virus | 1982 |
Role of transmethylation in the elicitation of an oxidative burst in macrophages.
Topics: Adenosine; Animals; Concanavalin A; Depression, Chemical; Guinea Pigs; Homocysteine; Lectins; Macrophage Activation; Macrophages; Methylation; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Oxygen; Superoxides; Tubercidin; Wheat Germ Agglutinins | 1982 |
Decreased methionine synthesis in purine nucleoside-treated T and B lymphoblasts and reversal by homocysteine.
Topics: Adenosine; B-Lymphocytes; Cell Line; Deoxyadenosines; Deoxyguanosine; Guanosine; Homocysteine; Humans; Inosine; Lymphocyte Activation; Methionine; Purine Nucleosides; T-Lymphocytes; Vidarabine | 1984 |
The effects of S-adenosyl methionine (AdoMet) and its analogues on the control of transcription and translation in vitro of the mRNA products of two cytoplasmic polyhedrosis viruses.
Topics: Adenosine; Cell-Free System; DNA-Directed RNA Polymerases; Ethionine; Homocysteine; Insect Viruses; Kinetics; Plants; Protein Biosynthesis; Ribonucleotides; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity; Transcription, Genetic; Triticum | 1983 |
Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Deoxyadenosines; Formycins; Homocysteine; Hydrolases; Purine-Nucleoside Phosphorylase; Rats; Spermidine Synthase; Spermine Synthase; Thionucleosides | 1983 |
Brain methylation and epileptogenesis: the case of methionine sulfoximine.
Topics: Adenosine; Animals; Brain; Epilepsy; Histamine; Homocysteine; Methionine; Methionine Sulfoximine; Methylation; Methylhistamines; Mice; Nerve Tissue Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Correlations between phospholipid methylation and neuronal catecholamine transport.
Topics: Adenine; Adenosine; Animals; Biological Transport; Cerebral Cortex; Cytosol; Homocysteine; Kinetics; Male; Membrane Lipids; Methylation; Norepinephrine; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; Synaptosomes | 1984 |
Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.
Topics: Adenosine; Aspartic Acid; Erythrocyte Membrane; Erythrocytes; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Line; Cell Separation; Clone Cells; Homocysteine; Hydrolases; Lymphoma; Mice; S-Adenosylhomocysteine; T-Lymphocytes | 1983 |
S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine.
Topics: Acute Disease; Adenosine; Adult; Coformycin; Deoxyadenosines; Drug Resistance; Drug Therapy, Combination; Erythrocytes; Homocysteine; Humans; Leukemia, Lymphoid; Lymphocytes; Male; Pentostatin; Ribonucleosides; S-Adenosylhomocysteine; Time Factors; Vidarabine | 1983 |
Effect of 2'-deoxycoformycin infusion on S-adenosylhomocysteine hydrolase and the amount of S-adenosylhomocysteine and related compounds in tissues of mice.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosylhomocysteinase; Animals; Coformycin; Deoxyadenosines; Homocysteine; Hydrolases; Infusions, Parenteral; Jejunum; Kidney; Kinetics; Liver; Mice; Nucleoside Deaminases; Organ Specificity; Pentostatin; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1983 |
Possible role of increased brain methylation in methionine sulfoximine epileptogenesis: effects of administration of adenosine and homocysteine thiolactone.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Histamine; Homocysteine; Methionine Sulfoximine; Methylation; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Phospholipids; Reaction Time; Seizures | 1983 |
Homocysteine in tissues of the mouse and rat.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Homocysteine; Mice; Rats; S-Adenosylhomocysteine; Species Specificity; Tissue Distribution | 1984 |
S-adenosylhomocysteine hydrolase as a pharmacological target for the inhibition of transmethylation.
Topics: Adenosine; Animals; Enzyme Inhibitors; Homocysteine; Isomerism; Kinetics; Mice; Ribonucleosides; S-Adenosylhomocysteine; Structure-Activity Relationship; Tubercidin | 1984 |
Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants.
Topics: Adenine; Adenosine; Arachidonic Acid; Arachidonic Acids; Chemical Phenomena; Chemistry; Chemoreceptor Cells; Chemotaxis, Leukocyte; Homocysteine; Humans; Kinetics; Lipid Metabolism; Methylation; Monocytes | 1981 |
Adenosine metabolism: modification by S-adenosylhomocysteine and 5'-methylthioadenosine.
Topics: Adenosine; Adenosine Kinase; Adenosylhomocysteinase; B-Lymphocytes; Cells, Cultured; Deoxyadenosines; Erythrocytes; Homocysteine; Humans; Hydrolases; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; T-Lymphocytes; Thionucleosides | 1982 |
Binding of adenosine to intracellular S-adenosylhomocysteine hydrolase in isolated rat hepatocytes.
Topics: Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Animals; Chromatography, High Pressure Liquid; Homocysteine; Hydrolases; Isoelectric Focusing; Liver; Rats; Tubercidin; Vidarabine | 1983 |
In vivo elevation of mouse brain S-adenosyl-L-homocysteine after treatment with L-homocysteine.
Topics: Adenosine; Animals; Brain; Homocysteine; Kinetics; Male; Mice; S-Adenosylhomocysteine | 1983 |
Adenosine metabolism in a rat hippocampal slice preparation: incorporation into S-adenosylhomocysteine.
Topics: Adenosine; Animals; Carbon Radioisotopes; Hippocampus; Homocysteine; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine | 1983 |
A sensitive radiochemical enzyme assay for S-adenosyl-L-homocysteine and L-homocysteine.
Topics: Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Animals; Aspergillus oryzae; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Homocysteine; Humans; Hydrolases; Leukemia, Lymphoid; Liver; Lymphocytes; Methods; Mice; S-Adenosylhomocysteine; Tritium | 1981 |
Perturbations in S-adenosylhomocysteine and S-adenosylmethionine metabolism: effects on transmethylation.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Lymphocytes; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1980 |
S-Adenosylhomocysteine accumulation and selective cytotoxicity in cultured T- and B-lymphocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosylhomocysteinase; B-Lymphocytes; Cell Division; Cells, Cultured; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Nucleoside Deaminases; S-Adenosylhomocysteine; T-Lymphocytes | 1982 |
Capping and adenosine metabolism. Genetic and pharmacologic studies.
Topics: Adenosine; Adenosine Deaminase; Animals; Bone Marrow Transplantation; Coformycin; Contractile Proteins; Homocysteine; Humans; Immunologic Capping; Lymphocytes; Mice; Tubercidin | 1980 |
The regional concentrations of S-adenosyl-L-methionine, S-adenosyl-L-homocysteine, and adenosine in rat brain.
Topics: Adenosine; Aging; Animals; Brain; Brain Chemistry; Homocysteine; Male; Pineal Gland; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tissue Distribution | 1982 |
Effect of 9-beta-D-arabinofuranosyladenine and erythro-9-(2-hydroxy-3-nonyl) adenine on the metabolism of S-adenosylhomocysteine, S-adenosylmethionine, and adenosine in rat liver.
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Female; Homocysteine; Hydrolases; Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Vidarabine | 1982 |
Inhibition of phospholipid methylation in isolated rat hepatocytes by analogues of adenosine and S-adenosylhomocysteine.
Topics: Adenosine; Animals; Homocysteine; In Vitro Techniques; Liver; Methylation; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Phospholipids; Rats; S-Adenosylhomocysteine | 1982 |
Decreased in vivo protein and phospholipid methylation after in vivo elevation of brain S-adenosyl-homocysteine.
Topics: Adenosine; Animals; Brain; Homocysteine; Male; Methylation; Mice; Nerve Tissue Proteins; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Decreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-l-homocysteine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Biogenic Amines; Brain; Catechol O-Methyltransferase Inhibitors; Histamine; Histamine N-Methyltransferase; Homocysteine; Hydrolases; Liver; Male; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Interaction of S-adenosylhomocysteine with isolated rat hepatocytes.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Biological Transport, Active; Cell Membrane; Homocysteine; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Rats; S-Adenosylhomocysteine | 1981 |
Role of S-adenosylhomocysteine hydrolase in adenosine metabolism in mammalian heart.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cats; Dogs; Guinea Pigs; Heart; Homocysteine; Hydrolases; Hypoxia; In Vitro Techniques; Kinetics; Myocardium; Rabbits; Rats; S-Adenosylhomocysteine; Species Specificity | 1981 |
Characterization of adenosine-induced cytostasis in melanoma cells.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Count; Cell Division; Cell Line; Guanosine; Homocysteine; Melanoma; Methylation; Mice; Neoplasms, Experimental; Pyrimidines; RNA, Neoplasm; Uridine | 1980 |
S-Adenosylhomocysteine metabolism in adenosine deaminase deficient cells.
Topics: Adenosine; Adenosine Deaminase; Adenosylhomocysteinase; Cell Survival; Cells, Cultured; Homocysteine; Humans; Hydrolases; Lymphocytes; Nucleoside Deaminases; S-Adenosylhomocysteine | 1980 |
S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocystein, and adenosine.
Topics: Adenosine; Animals; DNA; Female; Histones; Homocysteine; Kinetics; Liver; Methionine; Perfusion; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
The rate of transmethylation in mouse liver as measured by trapping S-adenosylhomocysteine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Homocysteine; Hydrolases; Liver; Methylation; Mice; S-Adenosylhomocysteine | 1980 |
Homocysteine enhances the inhibitory effect of extracellular adenosine on the synthesis of proteins in isolated rat hepatocytes.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Survival; Cells, Cultured; Drug Synergism; Homocysteine; Hydrolases; Inosine; Kinetics; Liver; Male; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1995 |
Inhibition of protein synthesis induced by adenine nucleotides requires their metabolism into adenosine.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Animals; Biological Transport; Cells, Cultured; Cyclic AMP; Homocysteine; L-Lactate Dehydrogenase; Leucine; Liver; Male; Protein Biosynthesis; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2 | 1995 |
Mechanism of erythrocyte accumulation of methylation inhibitor S-adenosylhomocysteine in uremia.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Aspartate Aminotransferases; Erythrocytes; Female; Homocysteine; Humans; Hydrolases; Male; Methylation; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Uremia | 1995 |
The methyltransferase inhibitor Neplanocin A interferes with influenza virus replication by a mechanism different from that of 3-deazaadenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Chick Embryo; Drug Synergism; Homocysteine; Hydrolases; Influenza A virus; Methionine; Methyltransferases; RNA Caps; RNA, Viral; S-Adenosylhomocysteine; Tubercidin; Viral Proteins; Virus Replication | 1995 |
Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells.
Topics: Adenosine; Cell Line; Cell Survival; Drug Synergism; Homocysteine; In Vitro Techniques; Methylation; NF-kappa B; Reactive Oxygen Species; S-Adenosylhomocysteine; Tumor Necrosis Factor-alpha | 1994 |
Steady-state catecholamine stimulation does not increase cytosolic adenosine in canine hearts.
Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Cardiac Pacing, Artificial; Catecholamines; Coronary Circulation; Cytosol; Dogs; Heart; Heart Rate; Hemodynamics; Homocysteine; Homocystine; Myocardial Ischemia; Myocardium; Oxygen Consumption; Reference Values; S-Adenosylhomocysteine | 1994 |
The bis(adenosin-N6-yl) alkanes, a family of potential dinucleoside polyphosphate analogue precursors. Mechanism of growth inhibition and suppression of adenosine toxicity in lymphoid cells.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Division; Cell Line; Deoxyadenosines; Drug Interactions; Homocysteine; Hydrolases; Lymphocytes; Rats; Tumor Cells, Cultured; Uridine | 1993 |
Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion.
Topics: Adenosine; Adenosine Diphosphate; Animals; Electric Stimulation; Energy Metabolism; Hippocampus; Homocysteine; In Vitro Techniques; Intracellular Membranes; Male; Purines; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine | 1993 |
Attenuation of ischemia-induced extracellular adenosine accumulation by homocysteine.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Extracellular Space; Homocysteine; Hypoxanthine; Hypoxanthines; Inosine; Male; Rats; Rats, Wistar; S-Adenosylhomocysteine | 1993 |
Apoptosis and transmethylation metabolites in HL-60 cells.
Topics: Adenosine; Apoptosis; DNA; DNA Fragmentation; Enzyme Inhibitors; HL-60 Cells; Homocysteine; Humans; Methylation; Methyltransferases; Nucleic Acid Synthesis Inhibitors; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1996 |
Determinants of the S-adenosylhomocysteine (SAH) technique for the local assessment of cardiac free cytosolic adenosine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cytosol; Dogs; Heart; Homocysteine; Hydrolases; Myocardium; S-Adenosylhomocysteine | 1997 |
Nerve growth factor-specific regulation of protein methylation during neuronal differentiation of PC12 cells.
Topics: Adenosine; Animals; Cell Differentiation; Cell-Free System; DNA Methylation; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Homocysteine; Kinetics; Methionine; Methylation; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Processing, Post-Translational; Rats; S-Adenosylmethionine; Signal Transduction; Tritium | 1997 |
Effects of homocysteine on acetylcholine- and adenosine-induced vasodilatation of pancreatic vascular bed in rats.
Topics: Acetylcholine; Adenosine; Animals; Cell Division; Cells, Cultured; Endothelium, Vascular; Homocysteine; Humans; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pancreas; Perfusion; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1997 |
The possible role of protein-carboxyl methylation in the regulation of flagellar movement of fowl spermatozoa.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium Chloride; Chickens; Enzyme Inhibitors; Homocysteine; Luminescent Measurements; Male; Marine Toxins; Methylation; Oxazoles; Proteins; Semen; Sperm Motility; Sperm Tail; Tubercidin | 2000 |
Hypomethylation as a cause of homocysteine-induced cell damage in human cell lines.
Topics: Adenosine; Cell Division; Cell Line; Endothelium, Vascular; Glutathione; HeLa Cells; Homocysteine; Humans; Myelin Sheath; Proteins | 2000 |
Adenosine- and 2-chloro-adenosine-induced cytopathic effects on myoblastic cells and myotubes: involvement of different intracellular mechanisms.
Topics: 2-Chloroadenosine; Acetylcysteine; Actin Cytoskeleton; Adenosine; Adenosine Kinase; Animals; Apoptosis; Cell Adhesion; Cell Line; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Homocysteine; Intracellular Fluid; Mice; Microscopy, Electron, Scanning; Muscle, Skeletal; Purinergic P1 Receptor Antagonists; Reactive Oxygen Species; Thioinosine; Tubercidin | 2000 |
Quantitative integration of different sites of adenosine metabolism in the heart.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Binding, Competitive; Biological Transport; Blood Flow Velocity; Cell Membrane; Cells, Cultured; Coronary Circulation; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Guinea Pigs; Homocysteine; In Vitro Techniques; Models, Cardiovascular; Muscle, Smooth, Vascular; Myocardium; S-Adenosylhomocysteine; Thioinosine | 2000 |
Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis.
Topics: Adenosine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cattle; Crk-Associated Substrate Protein; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Endothelium, Vascular; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Homocysteine; Hydrolysis; Paxillin; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Tyrosine; Vanadates; Vinculin | 2001 |
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
Topics: Adenosine; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cystathionine beta-Synthase; Cysteine; DNA Methylation; Down Syndrome; Glutathione; Homocysteine; Humans; Leucovorin; Lymphocytes; Methionine; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Superoxide Dismutase; Thymidine; Vitamin B 12 | 2001 |
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle.
Topics: Adenosine; Adenosylhomocysteinase; Caffeine; Carbon Dioxide; Cell Extracts; Chloroplasts; Homocysteine; Hydrolases; Methionine Adenosyltransferase; Methylation; Plant Leaves; S-Adenosylhomocysteine; S-Adenosylmethionine; Tea; Theobromine | 2001 |
FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase.
Topics: Adenosine; Animals; Apoptosis; Catalytic Domain; Cattle; Cell Survival; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Endothelium, Vascular; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; Homocysteine; Paxillin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein-Tyrosine Kinases; Proteins; Pulmonary Artery; Retinoblastoma-Like Protein p130; Signal Transduction; Transfection | 2002 |
Tissue levels of S-adenosylhomocysteine in the rat kidney: effects of ischemia and homocysteine.
Topics: Adenosine; Animals; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Fluorescence; Hemodynamics; Homocysteine; Hydrolases; Hyperhomocysteinemia; Kidney; Rats; Rats, Sprague-Dawley; Reference Standards; Risk Factors; Tubercidin | 2002 |
High oxidized LDL and elevated plasma homocysteine contribute to the early reduction of myocardial flow reserve in healthy adults.
Topics: Adenosine; Adult; Autoantibodies; Biomarkers; C-Reactive Protein; Cell Adhesion Molecules; Chlamydophila Infections; Chlamydophila pneumoniae; Cholesterol; Cholesterol, HDL; Coronary Circulation; Coronary Disease; Ferritins; Homocysteine; Humans; Image Processing, Computer-Assisted; Linear Models; Lipoproteins, LDL; Male; Regional Blood Flow; Risk Factors; Smoking; Tomography, Emission-Computed; Triglycerides | 2002 |
Adenosine-the missing link to understanding homocysteine pathogenicity or more smoke on the horizon?
Topics: Adenosine; Cardiovascular Diseases; Cardiovascular System; Homocysteine; Humans; Hyperhomocysteinemia | 2003 |
Synthesis and properties of adenosyl-L-homocysteine.
Topics: Adenosine; Cysteine; Homocysteine | 1958 |
The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine.
Topics: Adenosine; Cysteine; Homocysteine | 1959 |
Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation.
Topics: Adenosine; Adherens Junctions; Animals; Cattle; Cell Membrane Permeability; Cells, Cultured; Cysteine; Diterpenes; Electrophoresis, Gel, Two-Dimensional; Endothelial Cells; Green Fluorescent Proteins; Homocysteine; Luminescent Proteins; Methylation; Protein Methyltransferases; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; rhoA GTP-Binding Protein | 2004 |
Increased homocysteine and decreased adenosine formation in Alzheimer's disease.
Topics: Adenosine; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cerebrovascular Disorders; Down-Regulation; Female; Homocysteine; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Neuroprotective Agents; Predictive Value of Tests; S-Adenosylhomocysteine; Up-Regulation | 2004 |
Barrier dysfunction and RhoA activation are blunted by homocysteine and adenosine in pulmonary endothelium.
Topics: Adenosine; Animals; Cattle; Cell Membrane Structures; Cells, Cultured; Endothelium, Vascular; Homocysteine; Kinetics; Pulmonary Circulation; rhoA GTP-Binding Protein; Signal Transduction; Thrombin | 2004 |
S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Caspase 8; Caspases; Cell Line, Tumor; Hepatocytes; Homocysteine; Humans; Liver Diseases, Alcoholic; Methylation; Mice; Mice, Inbred C57BL; NF-kappa B; S-Adenosylhomocysteine; Tumor Necrosis Factor-alpha | 2004 |
Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia.
Topics: Adenosine; Adult; Cystathionine beta-Synthase; Erythrocytes; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Microdialysis; Plethysmography; Receptors, Purinergic P1 | 2005 |
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
Topics: Adenosine; Autistic Disorder; Betaine; Biomarkers; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cysteine; Female; Glutathione; Homocysteine; Humans; Leucovorin; Male; Methionine; Methylation; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 2004 |
S-adenosylhomocysteine hydrolase from the archaeon Pyrococcus furiosus: biochemical characterization and analysis of protein structure by comparative molecular modeling.
Topics: Adenosine; Adenosylhomocysteinase; Amino Acid Sequence; Catalysis; Cloning, Molecular; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Homocysteine; Hot Temperature; Kinetics; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyrococcus; Pyrococcus furiosus; Recombinant Proteins; Sequence Homology, Amino Acid; Sulfolobus solfataricus; Temperature; Threonine | 2005 |
Elimination of high amounts of extracellular homocysteine in human cell lines.
Topics: Adenosine; Antioxidants; Arteriosclerosis; Carcinoma, Hepatocellular; Cell Line, Tumor; HeLa Cells; Homocysteine; Humans; Hyperhomocysteinemia; Thioctic Acid | 2005 |
Effects of homocysteine on the dopaminergic system and behavior in rodents.
Topics: Adenosine; Animals; Behavior, Animal; Brain Chemistry; Catheterization; Chromatography, High Pressure Liquid; Dopamine; Homocysteine; Immunohistochemistry; Injections, Intraventricular; Male; Methylation; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Inhibition of transmethylation disturbs neurulation in chick embryos.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Chick Embryo; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Embryonic Development; Homocysteine; Methylation; Models, Biological; Nervous System; Organogenesis; S-Adenosylhomocysteine; Time Factors; Tubercidin | 2005 |
The polyphenol quercetin strongly increases homocysteine production in a human hepatoma (Hep G2) cell line.
Topics: Adenosine; Adenosylhomocysteinase; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Inhibitors; HeLa Cells; Homocysteine; Humans; Quercetin | 2006 |
The role of adenosine in chondrocyte death in murine osteoarthritis and in a murine chondrocyte cell line.
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Apoptosis; Cartilage, Articular; Cell Death; Cell Line; Chondrocytes; DNA Fragmentation; Enzyme Inhibitors; Homocysteine; Male; Mice; Mice, Inbred Strains; Osteoarthritis; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Tubercidin | 2006 |
Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker.
Topics: Acetylcholine; Adenosine; Animals; Anti-Arrhythmia Agents; Atropine; Calcium Channel Blockers; Coronary Circulation; Dose-Response Relationship, Drug; Heart Rate; Homocysteine; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rats; Rats, Sprague-Dawley; Theophylline; Vasodilation; Vasodilator Agents | 2006 |
Changes in atrium and thoracic aorta reactivity to adenosinergic and adrenergic agonists in experimental hyperhomocysteinemia.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Blood Pressure; Dipyridamole; Heart Atria; Heart Rate; Homocysteine; Hyperhomocysteinemia; Isoproterenol; Male; Methionine; Phenylephrine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Theophylline; Vasoconstriction; Vasodilation | 2006 |
Investigation of bioisosteric effects on the interaction of substrates/ inhibitors with the methionyl-tRNA synthetase from Escherichia coli.
Topics: Adenosine; Adenosine Monophosphate; Anti-Bacterial Agents; Enzyme Inhibitors; Escherichia coli; Homocysteine; Methionine; Methionine-tRNA Ligase; Organophosphonates; Phosphinic Acids; Protein Conformation; Stereoisomerism; Substrate Specificity | 2005 |
Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosylhomocysteinase; Apoptosis; Caspase Inhibitors; Caspases; Dipyridamole; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Homocysteine; Humans; Methylation; Nucleoside Transport Proteins; Oligonucleotide Array Sequence Analysis; Pentostatin; Proto-Oncogene Proteins c-mdm2; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Long-term administration of 3-deazaadenosine does not alter progression of advanced atherosclerotic lesions in apolipoprotein E-deficient mice.
Topics: Actins; Adenosine; Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Homocysteine; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1beta; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Transcription Factor AP-1; Tubercidin; Vascular Cell Adhesion Molecule-1 | 2007 |
Homocysteine-induced endothelial cell adhesion is related to adenosine lowering and is not mediated by S-adenosylhomocysteine.
Topics: Adenosine; Cell Adhesion; Cell Line, Tumor; Endothelial Cells; Homocysteine; Humans | 2007 |
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Topics: Adenosine; Adenosylhomocysteinase; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Histidine; Homocysteine; Models, Molecular; Mycobacterium tuberculosis; NAD; Protein Structure, Tertiary | 2008 |
Impaired endothelial function and insulin action in first-degree relatives of patients with type 2 diabetes mellitus.
Topics: Acetylcholine; Adenosine; Adult; Blood Gas Analysis; Blood Glucose; C-Peptide; C-Reactive Protein; Cholesterol; Diabetes Mellitus, Type 2; Endothelium, Vascular; Family; Glucose Clamp Technique; Homocysteine; Humans; Insulin; Insulin Resistance; Male; Plethysmography; Potassium; Statistics, Nonparametric; Vascular Resistance; Vasodilator Agents | 2009 |
Imprinting: RNA expression for homocysteine recycling in the human oocyte.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosine; Betaine-Homocysteine S-Methyltransferase; Blastocyst; Cystathionine beta-Synthase; DNA Methylation; Ethionine; Female; Fertilization in Vitro; France; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Genomic Imprinting; Homocysteine; Humans; Methionine; Oligonucleotide Array Sequence Analysis; Oocytes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Synergistic effects of homocysteine, S-adenosylhomocysteine and adenosine on apoptosis in BV-2 murine microglial cells.
Topics: Adenosine; Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line; Cell Survival; Drug Synergism; Homocysteine; Methylation; Mice; Microglia; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; S-Adenosylhomocysteine | 2008 |
Endothelial function after 10 days of bed rest in individuals at risk for type 2 diabetes and cardiovascular disease.
Topics: Acetylcholine; Adenosine; Adult; Bed Rest; C-Reactive Protein; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium, Vascular; Forearm; Homocysteine; Humans; Hyperinsulinism; Infant, Low Birth Weight; Infant, Newborn; Insulin; Intercellular Adhesion Molecule-1; Male; Regional Blood Flow; Risk; Vascular Cell Adhesion Molecule-1; Vasodilation | 2011 |
Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox).
Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Cell Membrane; Cell Nucleus; Cell Survival; Extracellular Space; Homocysteine; Intracellular Space; Membrane Glycoproteins; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Phospholipid Transfer Proteins; Rats; Reactive Oxygen Species; S-Adenosylhomocysteine; S-Adenosylmethionine; Tyrosine | 2011 |
S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine.
Topics: Adenosine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Cytochromes c; Endothelial Cells; Enzyme Inhibitors; Homocysteine; Humans; Hydrogen Peroxide; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; Phosphatidylserines; S-Adenosylhomocysteine; Tyrosine | 2012 |
Combination of TNF-α, homocysteine and adenosine exacerbated cytotoxicity in human cardiovascular and cerebrovascular endothelial cells.
Topics: Adenosine; Apoptosis; Caspase 3; Cell Line; Cell Survival; Endothelial Cells; Endothelium, Vascular; Homocysteine; Humans; Poly(ADP-ribose) Polymerases; Tumor Necrosis Factor-alpha | 2012 |
A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples.
Topics: Adenosine; Adenosylhomocysteinase; Biological Assay; Fluorescence; HeLa Cells; Homocysteine; Humans; S-Adenosylhomocysteine | 2013 |
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil | 2014 |
Design and synthesis of amide derivatives as S-adenosyl-L-homocysteine hydrolase inhibitors.
Topics: Adenosine; Amides; Homocysteine; Hydrolases; Structure-Activity Relationship | 2014 |
Gallic acid protects against endothelial injury by restoring the depletion of DNA methyltransferase 1 and inhibiting proteasome activities.
Topics: Adenosine; Cell Survival; Cytoprotection; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Interactions; Endothelial Cells; Flow Cytometry; Gallic Acid; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Membrane Potential, Mitochondrial; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2014 |
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Animals; Brain Chemistry; Drug Design; Enzyme Activation; Enzyme Inhibitors; Homocysteine; Hydrogen Bonding; Hydrolases; Inhibitory Concentration 50; Models, Molecular; Rats; S-Adenosylhomocysteine; Substrate Specificity | 2014 |
Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth.
Topics: Adenosine; Animals; Biofilms; Colony Count, Microbial; Gene Expression Regulation, Bacterial; Homocysteine; Otitis Media; Plankton; Rats, Sprague-Dawley; S-Adenosylmethionine; Streptococcus pneumoniae | 2014 |
An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii.
Topics: Adenosine; Adenosylhomocysteinase; Bacterial Proteins; Binding Sites; Biocatalysis; Bradyrhizobium; Crystallography, X-Ray; Escherichia coli; Gene Expression; Homocysteine; Models, Molecular; NAD; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Nucleoside Transport Inhibition by Dipyridamole Prevents Angiogenesis Impairment by Homocysteine and Adenosine.
Topics: Adenosine; Biological Transport, Active; Capillaries; Cell Line; Cell Movement; Cell Proliferation; Dipyridamole; Endothelial Cells; Homocysteine; Humans; MAP Kinase Signaling System; Neovascularization, Pathologic; Nucleosides; Phosphorylation; S-Adenosylhomocysteine; Vasodilator Agents; Wound Healing | 2015 |
Adenosine plasma level correlates with homocysteine and uric acid concentrations in patients with coronary artery disease.
Topics: Adenosine; Aged; Case-Control Studies; Coronary Artery Disease; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Tumor Cells, Cultured; Uric Acid | 2016 |
High homocysteine levels prevent via H2 S the CoCl2 -induced alteration of lymphocyte viability.
Topics: Adenosine; Adult; Alkynes; Cell Hypoxia; Cell Survival; Cobalt; Glycine; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Lymphocytes; Middle Aged; Models, Biological; Signal Transduction | 2016 |
Oxymatrine Inhibits Homocysteine-Mediated Autophagy via MIF/mTOR Signaling in Human Umbilical Vein Endothelial Cells.
Topics: Adenosine; Alkaloids; Apoptosis; Autophagy; Caspase 3; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Quinolizines; RNA Interference; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |