homocysteine has been researched along with 5-methyltetrahydrofolate in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (9.52) | 18.7374 |
| 1990's | 23 (18.25) | 18.2507 |
| 2000's | 49 (38.89) | 29.6817 |
| 2010's | 28 (22.22) | 24.3611 |
| 2020's | 14 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Banerjee, RV; González, JC; Huang, S; Matthews, RG; Sumner, JS | 1 |
| Christensen, B; Garras, A; Refsum, H; Ueland, PM | 1 |
| Hipwell, SE; Liteplo, RG; Lue-Shing, H; Rosenblatt, DS; Sillaots, S | 1 |
| Christensen, B; Djurhuus, R; Refsum, H; Ueland, PM | 1 |
| Liteplo, RG | 1 |
| Baker, DH; Czarnecki, GL | 1 |
| Schalinske, KL; Steele, RD | 1 |
| Kvinnsland, S; Refsum, H; Ueland, PM | 1 |
| Barak, AJ; Beckenhauer, HC; Tuma, DJ | 2 |
| Barak, AJ; Tuma, DJ | 1 |
| Hilton, MA; Hoffman, JL; Sparks, MK | 1 |
| Tisdale, MJ | 1 |
| Barak, AJ; Kemmy, RJ; Tuma, DJ | 1 |
| Wickramasinghe, SN | 1 |
| Gottfries, CG; Johansson, BV; Regland, B | 1 |
| Hartley, R; Levene, MI; Lucock, MD; Schorah, CJ; Wild, J | 1 |
| Drummond, JT; Matthews, RG | 1 |
| Blumenthal, RM; Drummond, JT; Huang, S; Matthews, RG | 1 |
| Angst, CP; Fowler, B; Haefeli, WE; Jordan, PP; Loehrer, FM; Ritz, R | 1 |
| Blom, HJ; Eskes, TK; Monnens, IA; te Poele Pothoff, MT; van den Heuvel, LP; van der Molen, EF | 1 |
| Angst, CP; Browne, G; Fowler, B; Frick, G; Haefeli, WE; Loehrer, FM | 1 |
| González, JC; Matthews, RG; Peariso, K; Penner-Hahn, JE | 1 |
| Goulding, CW; Matthews, RG; Postigo, D | 1 |
| Banerjee, R; Chen, Z; Gulati, S | 1 |
| Fluhr, K; Goulding, CW; Huang, S; Jarrett, JT; Matthews, RG | 1 |
| Angst, CP; Fowler, B; Haefeli, WE; Loehrer, FM; Schwab, R | 1 |
| Choi, CY; Jarrett, JT; Matthews, RG | 1 |
| Goulding, CW; Matthews, RG | 1 |
| Brunone, M; De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Kastelein, JJ; Koomans, HA; Rabelink, TJ; van Dam, T; Verhaar, MC; Wever, RM | 1 |
| Chadefaux-Vekemans, B; Garcia, MJ; Jakobs, C; Kamoun, P; Merinero, B; Pérez-Cerdá, C; Tonetti, C; Ugarte, M; Zittoun, J | 1 |
| Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH | 1 |
| Cerbone, AM; Coppola, A; D'Angelo, A; Fermo, I; Galli, L; Madonna, P; Mazzola, G; Pagano, A | 1 |
| Bagley, P; Bostom, AG; Christopher, K; Dworkin, L; Jacques, PF; Massy, ZA; Selhub, J; Shemin, D; Spiegel, P; Zanabli, A | 1 |
| Bagley, PJ; Rosenberg, IH; Selhub, J; Stern, LL | 1 |
| Finkelstein, JD | 1 |
| Rozen, R | 1 |
| Ames, BN; Jacob, RA; Johnston, KE; Mayr, CA; Tamura, T; Wallock, LM | 1 |
| Doshi, SN; Goodfellow, J; Kredan, MB; Lang, D; Lewis, MJ; McDowell, IF; Moat, SJ; Newcombe, RG | 1 |
| Higgins, JA; Nakano, E; Powers, HJ | 1 |
| Doshi, SN; Durrant, HJ; Goodfellow, J; Lewis, MJ; McDowell, IF; Moat, SJ; Payne, N | 1 |
| Bellet, H; Bounameaux, H; Daurès, JP; Dauzat, M; de Moerloose, P; Gris, JC; Janbon, C; Laroche, JP; Mercier, E; Perneger, TV; Quéré, I; Schved, JF; Zittoun, J | 1 |
| Bamonti, F; Baragetti, I; Buccianti, G; Catapano, AL; Corghi, E; Maggi, FM; Novembrino, C; Patrosso, C; Raselli, S | 1 |
| Lucock, M; Yates, Z | 1 |
| Green, TJ; Mann, JI; Moser, R; Venn, BJ | 1 |
| Bandarian, V; Ludwig, ML; Matthews, RG | 1 |
| Bagley, PJ; Lathrop Stern, L; Nadeau, M; Selhub, J; Shane, B; Shih, V | 1 |
| BUCHANAN, JM; ROSENTHAL, S; SMITH, LC | 1 |
| WOLFE, RS; WOOD, JM | 1 |
| Chada, L; McGaw, J; Nakano, E; Powers, HJ; Taylor, CJ | 1 |
| Ozias, MK; Schalinske, KL | 1 |
| Doshi, S; Goodfellow, J; Lewis, M; McDowell, I; Moat, S | 1 |
| Abeles, R; Gold, V; Michael, E; Nachmany, A; Weil, M | 1 |
| Dennis, M; Eikelboom, JW; Icke, GC; Nicol, DJ; Sjollema, S | 1 |
| Lamers, Y; Moser, R; Pietrzik, K; Prinz-Langenohl, R | 1 |
| Akoglu, B; Caspary, WF; Faust, D; Milovic, V | 1 |
| Basten, GP; Duthie, SJ; Hill, MH; Powers, HJ | 1 |
| Dumas, R; Ferrer, JL; Ravanel, S; Robert, M | 1 |
| Basten, G; Duthie, SJ; Little, J; McConnell, J; Narayanan, S; Piyathilake, CJ; Powers, H; Sharp, L | 1 |
| Fathi, Z; Golbahar, J; Tamadon, M | 1 |
| Becker, A; Bouter, LM; Dekker, JM; Heine, RJ; Henry, RM; Jakobs, C; Kostense, PJ; Nijpels, G; Smulders, YM; Spijkerman, AM; Stehouwer, CD; Teerlink, T | 1 |
| Nelson, BC; Satterfield, MB; Sniegoski, LT; Welch, MJ | 1 |
| Branzi, A; Carigi, S; Coccolo, F; Grigioni, F; Kessels, K; Koessels, K; Magelli, C; Magnani, G; Marrozzini, C; Marzocchi, A; Musuraca, AC; Ortolani, P; Potena, L; Russo, A; Sassi, S | 1 |
| Aminzadeh, MA; Golbahar, J; Hamidi, SA; Omrani, GR | 1 |
| Dainty, JR; de Meer, K; Finglas, PM; Jakobs, C; Kok, RM; Smith, DE; Smulders, YM; Stehouwer, CD | 1 |
| Cajani, A; Coppola, A; D'Angelo, A; Di Minno, G; Di Minno, MN; Fermo, I; Folco, G; Mazzola, G; Sala, A; Tremoli, E | 1 |
| Jakobs, C; Kok, RM; Smith, DE; Smulders, YM; Stehouwer, CD; Swinkels, DW; Teerlink, T | 1 |
| Baudo, F; Campolo, J; Caruso, R; Cighetti, G; De Chiara, B; Dellanoce, C; Parodi, O; Parolini, M; Sedda, V; Tonini, A | 1 |
| Antoniades, C; Cai, S; Channon, KM; de Bono, J; Lee, J; Leeson, P; Neubauer, S; Pillai, R; Ratnatunga, C; Refsum, H; Shirodaria, C; Warrick, N | 1 |
| Akoglu, B; Bolouri, H; Caspary, WF; Faust, D; Jaffari, A; Kutschera, E; Schrott, M | 1 |
| Alberghini, E; Baragetti, I; Buccianti, G; Buzzi, L; Catapano, AL; Furiani, S; Garlaschelli, K; Raselli, S; Stucchi, A; Terraneo, V | 1 |
| Couston, C; McEneny, J; McKibben, B; Woodside, JV; Young, IS | 1 |
| Bal, W; Duckworth, Y; Gibney, E; Hill, MH; Mathers, JC; Powers, HJ; Russell, J; Spiers, A; Welfare, M; Williams, EA | 1 |
| Brachet, P; Cardinault, N; Chanson, A; D'Incan, M; Martin, JF; Rock, E; Souteyrand, P | 1 |
| Czarnowski, W; Marszałł, M | 1 |
| James, SJ; Karp, N; Li, D; Melnyk, S; Rozen, R; Wang, XL; Wu, Q | 1 |
| Duewer, DL; Lippa, KA; Nelson, BC; Pfeiffer, CM; Sharpless, KE; Zhang, M | 1 |
| Miller, AL | 1 |
| Assael, BM; Bambara, LM; Biondani, A; Bortolami, O; Carta, F; D'Orazio, C; De Franceschi, L; Faccini, G; Guarini, P; La Verde, V; Pattini, P; Poli, F; Scambi, C; Siciliano, A; Turrini, F | 1 |
| Antoniades, C; Baarholm, OA; Channon, KM; Cunnington, C; Leeson, P; Pillai, R; Ratnatunga, C; Refsum, H; Shirodaria, C; Stefanadis, C; Tousoulis, D; Van-Assche, T | 1 |
| Cvetanovska, G; Frommann, I; Jessen, F; Kölsch, H; Kornhuber, J; Lewczuk, P; Linnebank, M; Maier, W; Popp, J; Smulders, Y | 1 |
| Armon, MP; Clark, A; Finglas, PM; Jennings, B; Khandanpour, N; Meyer, FJ; Willis, G | 1 |
| Herrmann, W; Kirsch, SH; Knapp, JP; Obeid, R | 1 |
| Basten, GP; de Roos, B; Duncan, G; Duthie, SJ; Horgan, G; Pirie, L; Powers, HJ; Reid, M; Rucklidge, G | 1 |
| Kitamura, Y; Kusuhara, H; Sugiyama, Y | 1 |
| Chen, S; Le, W; Li, L; Wang, Q; Zhang, X | 1 |
| Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J | 1 |
| Hudson, PR; McCaddon, A | 1 |
| Berlin, KN; Cameron, LM; Gatt, M; Miller, RR | 1 |
| Bailey, RL; Betz, JM; Dodd, KW; Dwyer, JT; Gahche, JJ; Mills, JL; Pfeiffer, CM; Picciano, MF; Sempos, CT; Yetley, EA | 1 |
| Eckert, R; Herrmann, W; Kasoha, M; Kirsch, SH; Obeid, R | 1 |
| Armstrong, EJ; Brooks, BR; Hemendinger, RA | 1 |
| Ahluwalia, N; Blacher, J; Galan, P; Hercberg, S; Julia, C; Szabo de Edelenyi, F; Vergnaud, AC | 1 |
| Alpert, JE; Arning, E; Bottiglieri, T; Fava, M; Mischoulon, D; Papakostas, GI | 1 |
| Bal, W; Duckworth, Y; Gibney, ER; Hill, MH; Mathers, JC; Powers, HJ; Spiers, A; Welfare, M; Williams, EA | 1 |
| Hayakawa, T; Isa, Y; Nakagawa, T; Yamamoto, K | 1 |
| Andria, G; Carnovale, E; Genovese, O; Giardina, B; Iacoviello, L; Mastroiacovo, P; Minucci, A; Mistura, L; Persichilli, S; Pounis, G; Ricci, R; Ruggeri, S; Scala, I; Turrini, A; Zappacosta, B | 1 |
| Andras, A; Hansrani, M; Stansby, G | 1 |
| Chen, YM; Chiang, EP; Lin, WL; Lin, YJ; Tang, FY; Wang, YC | 1 |
| Guan, Z; Niu, B; Wang, J; Wang, X; Wang, Z; Xie, Q; Zhang, T; Zhao, X; Zhu, Z | 1 |
| Cagnacci, A; Cannoletta, M; Palma, F; Palmieri, B; Piacenti, I; Xholli, A | 1 |
| Ambrosino, P; Di Minno, A; Di Minno, MN; Lupoli, R; Lupoli, V; Marrone, E; Mitidieri, E; Nardo, A; Scaravilli, A; Tufano, A | 1 |
| Boyd, L; Choi, JH; Kim, J; Lucock, M; Martin, C; Ng, X; Skinner, V; Veysey, M; Wai, R; Woo, HD; Yates, Z | 1 |
| Bodis, M; Geisel, J; Herrmann, M; Herrmann, W; Hübner, U; Kirsch, SH; Laufs, U; Pusceddu, I; Wagenpfeil, S; Werner, C | 1 |
| Bednarska-Makaruk, M; Bochyńska, A; Dai, L; Graban, A; Harrington, DJ; Mitchell, M; Ryglewicz, D; Sobczyńska-Malefora, A; Voong, K; Wehr, H; Wiśniewska, A; Łojkowska, W | 1 |
| Kornhuber, J; Lewczuk, P; Linnebank, M; Oikonomidi, A; Popp, J; Semmler, A; Smulders, Y | 1 |
| Brzozowska, A; Finglas, PM; Roszkowski, W; Sicińska, E | 1 |
| Ng, GA; Ng, LL; Yuyun, MF | 1 |
| Kang, SS; Rosenson, RS | 1 |
| Clément, A; Clément, P; Cohen, M; Cornet, D; Menezo, Y | 1 |
| Austin, J; Galea, LAM; Gobinath, AR; Qiu, W; Wen, Y | 1 |
| Mazokopakis, EE | 1 |
| Ji, Y; Li, H; Lin, Z; Luo, H; Luo, W | 1 |
| Aschinger, G; Bata, A; Garhofer, G; Howorka, K; Puchner, S; Scheschy, U; Schmetterer, L; Schmidl, D; Stjepanek, K; Szegedi, S; Werkmeister, RM | 1 |
| Fukuoka, H; Kawabata, T; Kubo, Y; Mori, C; Nishikawa, M; Ohkubo, T; Oshida, K; Sakurai, K; Shoji, K; Yamashiro, Y; Yanagisawa, N | 1 |
| Geršak, K; Mlinarič-Raščan, I; Šmid, A; Trontelj, J; Vidmar Golja, M | 1 |
| Arkin, AP; Deutschbauer, AM; Price, MN | 1 |
| Bharadwaj, B; Dhiman, P; Pillai, RR; Premkumar, N; Rajendiran, S; Ranjan, VP; Wilson, AB | 1 |
| Fan, H; Guo, X; Li, J; Ni, J; Qi, Y; Wang, H; Wang, X; Wu, X; Yang, L | 1 |
| Cirillo, M; Coccia, ME; Fatini, C; Fucci, R; Rubini, S | 1 |
| Chen, D; Cheng, Y; Duan, Y; Hou, B; Huo, Y; Liang, Q; Liang, X; Liu, L; Liu, S; Liu, X; Qin, X; Song, Y; Tang, G; Wang, B; Wang, Z; Yan, F; Yang, Y; Zhang, N; Zhou, Z | 1 |
| Arning, E; Bottiglieri, T; Wasek, B | 1 |
| Fukuoka, H; Horiguchi, S; Kagawa, Y; Kawabata, T; Kubo, Y; Nishikawa, M; Shoji, K; Tajima, A | 1 |
| Mazokopakis, EE; Papadakis, JA; Papadomanolaki, MG | 1 |
9 review(s) available for homocysteine and 5-methyltetrahydrofolate
| Article | Year |
|---|---|
Betaine, metabolic by-product or vital methylating agent?
Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates | 1983 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deoxyuridine; Erythrocytes, Abnormal; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Homocysteine; Humans; Hypothyroidism; Lymphocyte Activation; Methionine; Pregnancy; Pregnancy Complications; Statistics as Topic; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
Pathways and regulation of homocysteine metabolism in mammals.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Homocysteine; Isoenzymes; Kinetics; Mammals; Methionine; Methionine Adenosyltransferase; Organ Specificity; Oxidation-Reduction; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tetrahydrofolates | 2000 |
Genetic modulation of homocysteinemia.
Topics: Amino Acid Substitution; Cardiovascular Diseases; Cystathionine beta-Synthase; Cysteine; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Mutation, Missense; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Sulfur; Tetrahydrofolates | 2000 |
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
Topics: Antioxidants; Biopterins; Depression; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Neurotransmitter Agents; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2008 |
L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.
Topics: Acetylcysteine; Alzheimer Disease; Cognition Disorders; Free Radical Scavengers; Homocysteine; Humans; Oxidative Stress; Plaque, Amyloid; Tetrahydrofolates; Vitamin B 12; Vitamin B Complex | 2010 |
Homocysteine lowering interventions for peripheral arterial disease and bypass grafts.
Topics: Arteriosclerosis; Disease Progression; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Peripheral Vascular Diseases; Randomized Controlled Trials as Topic; Tetrahydrofolates; Vascular Grafting; Vitamin B Complex | 2013 |
Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?
Topics: Biopterins; Cardiovascular Diseases; Dietary Supplements; Endothelium, Vascular; Folic Acid; Hemodynamics; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Tetrahydrofolates | 2018 |
Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease.
Topics: Animals; Betaine; Biomarkers; Cardiovascular Diseases; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Phenotype; Risk Factors; Tetrahydrofolates; Treatment Outcome | 2018 |
28 trial(s) available for homocysteine and 5-methyltetrahydrofolate
| Article | Year |
|---|---|
Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia.
Topics: Erythrocyte Membrane; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uremia | 1997 |
5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
Topics: Adult; Biological Availability; Dose-Response Relationship, Drug; Endothelium; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Hyperlipoproteinemia Type II; Hypoxanthine; Male; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Superoxides; Tetrahydrofolates; Vasodilation; Xanthine Oxidase | 1998 |
Controlled comparison of L-5-methyltetrahydrofolate versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Renal Dialysis; Tetrahydrofolates; Treatment Failure | 2000 |
Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?
Topics: Animals; Biopterins; Cells, Cultured; Coronary Disease; Cross-Over Studies; Cytoplasm; Dietary Supplements; Dilatation, Pathologic; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hemodynamics; Homocysteine; Humans; Injections, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Superoxides; Tetrahydrofolates | 2001 |
Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.
Topics: Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Middle Aged; Tetrahydrofolates; Time Factors; Treatment Outcome; Vasodilation | 2002 |
Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study.
Topics: Adult; Dietary Supplements; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; Middle Aged; Neural Tube Defects; Placebos; Tetrahydrofolates; Treatment Outcome; Vitamin B 12 Deficiency | 2003 |
Folate improves endothelial function in patients with coronary heart disease.
Topics: Administration, Oral; Brachial Artery; Coronary Disease; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Regional Blood Flow; Tetrahydrofolates; Vasodilation | 2003 |
Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.
Topics: Adult; Analysis of Variance; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Neural Tube Defects; Placebos; Tetrahydrofolates; Treatment Outcome; Vitamin B 12 Deficiency | 2004 |
Effect of folic Acid supplementation on the folate status of buccal mucosa and lymphocytes.
Topics: Adolescent; Adult; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Lymphocytes; Male; Middle Aged; Mouth Mucosa; Tetrahydrofolates | 2004 |
S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study.
Topics: Aged; Brachial Artery; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Nitroglycerin; Regional Blood Flow; Risk Factors; S-Adenosylmethionine; Tetrahydrofolates; Ultrasonography; Vasodilation; Vasodilator Agents; Vitamin B 12; Vitamin B 6 | 2005 |
Homocysteine-lowering therapy and early progression of transplant vasculopathy: a prospective, randomized, IVUS-based study.
Topics: Adult; Cytomegalovirus Infections; Disease Progression; Female; Folic Acid; Heart Diseases; Heart Transplantation; Homocysteine; Humans; Hyperhomocysteinemia; Hyperplasia; Male; Middle Aged; Prospective Studies; Research Design; Risk Factors; Tetrahydrofolates; Time Factors; Ultrasonography; Vascular Diseases | 2005 |
[6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults.
Topics: Adult; Aging; Area Under Curve; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Intestinal Absorption; Male; Middle Aged; Tetrahydrofolates | 2005 |
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Topics: Acetylcholine; Antioxidants; Atherosclerosis; Biological Availability; Biopterins; Bradykinin; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protein Binding; Superoxides; Tetrahydrofolates | 2006 |
The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled study.
Topics: Chromatography, High Pressure Liquid; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Transplantation; Male; Middle Aged; Prospective Studies; Tetrahydrofolates; Treatment Outcome | 2008 |
Improvement of endothelial function in uraemic patients on peritoneal dialysis: a possible role for 5-MTHF administration.
Topics: Aged; Diabetic Nephropathies; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis; Tetrahydrofolates; Ultrasonography; Uremia; Vasodilation | 2007 |
Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).
Topics: Adenomatous Polyposis Coli; Adult; Aged; Aged, 80 and over; Alleles; Biomarkers, Tumor; Biopsy; Colonoscopy; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Erythrocytes; Female; Folic Acid; Follow-Up Studies; Genetic Carrier Screening; Genetic Variation; Genotype; Homocysteine; Humans; Intestinal Mucosa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Riboflavin; Sigmoidoscopy; Tetrahydrofolates | 2007 |
Decreased plasma folate concentration in young and elderly healthy subjects after a short-term supplementation with isotretinoin.
Topics: Acne Vulgaris; Adult; Aged; Aging; Dermatologic Agents; Dietary Supplements; Folic Acid; Homocysteine; Humans; Isotretinoin; Male; Tetrahydrofolates | 2008 |
Preliminary evidence for cell membrane amelioration in children with cystic fibrosis by 5-MTHF and vitamin B12 supplementation: a single arm trial.
Topics: Antiporters; Cations; Child; Child, Preschool; Cystic Fibrosis; Dietary Supplements; Erythrocyte Membrane; Erythrocytes; Female; Homocysteine; HSP70 Heat-Shock Proteins; Humans; Ion Transport; Male; Malondialdehyde; Membrane Fluidity; Membrane Lipids; Oxidative Stress; Phospholipids; Tetrahydrofolates; Vitamin B 12 | 2009 |
Randomized clinical trial of folate supplementation in patients with peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Blood Flow Velocity; Cardiovascular Agents; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Intermittent Claudication; Male; Middle Aged; Tetrahydrofolates; Treatment Outcome | 2009 |
Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation.
Topics: Adult; Blood Coagulation; Blood Proteins; Dietary Supplements; Drug Administration Schedule; Female; Folic Acid; Homocysteine; Humans; Immunity; Inflammation; Male; Proteome; Proteomics; S-Adenosylmethionine; Tetrahydrofolates | 2010 |
Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults.
Topics: Aged; Aged, 80 and over; Aging; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2011 |
Effect of B-vitamins and n-3 PUFA supplementation for 5 years on blood pressure in patients with CVD.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Dietary Supplements; Double-Blind Method; Fatty Acids, Omega-3; Female; Follow-Up Studies; Homocysteine; Humans; Hypertension; Male; Middle Aged; Overweight; Patient Compliance; Tetrahydrofolates; Vitamin B Complex | 2012 |
Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder.
Topics: Biological Availability; Depressive Disorder, Major; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Psychiatric Status Rating Scales; S-Adenosylhomocysteine; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2012 |
Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia.
Topics: Adult; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Severity of Illness Index; Tetrahydrofolates; Vitamin B Complex | 2013 |
Folate administration decreases oxidative status and blood pressure in postmenopausal women.
Topics: Blood Glucose; Blood Pressure; Body Mass Index; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Homocysteine; Humans; Insulin; Insulin Resistance; Middle Aged; Oxidative Stress; Postmenopause; Tetrahydrofolates; Triglycerides | 2015 |
Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia.
Topics: Adult; Dietary Supplements; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Prospective Studies; Tetrahydrofolates; Treatment Outcome | 2015 |
Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults.
Topics: Aged; Body Mass Index; Diet; Dietary Supplements; Double-Blind Method; Exercise; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Socioeconomic Factors; Tetrahydrofolates; Vitamin B Complex | 2018 |
Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study.
Topics: Adult; Cross-Sectional Studies; Genotype; Homocysteine; Humans; Hypertension; Methylenetetrahydrofolate Reductase (NADPH2); Tetrahydrofolates | 2022 |
89 other study(ies) available for homocysteine and 5-methyltetrahydrofolate
| Article | Year |
|---|---|
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alkylation; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Homocysteine; Iodoacetamide; Methionine; Molecular Sequence Data; Recombinant Proteins; Restriction Mapping; Tetrahydrofolates; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin; Vitamin B 12 | 1992 |
Homocysteine remethylation during nitrous oxide exposure of cells cultured in media containing various concentrations of folates.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Mice; Nitrous Oxide; Tetrahydrofolates | 1992 |
Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Homocysteine; Humans; Melanoma; Methionine; Phenotype; Tetrahydrofolates; Tumor Cells, Cultured; Vitamin B 12 | 1991 |
Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Methotrexate; Mice; Neoplasms; Tetrahydrofolates; Thymidine | 1991 |
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.
Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured | 1990 |
Transmethylation of homocysteine to methionine: efficiency in the rat and chick.
Topics: Animals; Betaine; Body Weight; Chickens; Choline; Diet; Homocysteine; Male; Methionine; Methylation; Rats; Rats, Inbred Strains; Sarcosine; Tetrahydrofolates | 1985 |
Quantitation of carbon flow through the hepatic folate-dependent one-carbon pool in rats.
Topics: Animals; Biological Transport; Carbon; Homocysteine; Liver; Male; Methionine; Rats; Rats, Inbred Strains; Serine; Tetrahydrofolates; Time Factors | 1989 |
Acute and long-term effects of high-dose methotrexate treatment on homocysteine in plasma and urine.
Topics: Adolescent; Adult; Cells, Cultured; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Tetrahydrofolates | 1986 |
Ethanol, the choline requirement, methylation and liver injury.
Topics: Animals; Betaine; Choline; Ethanol; Folic Acid; Homocysteine; Liver; Methionine; Methylation; Rats; Tetrahydrofolates | 1985 |
Methotrexate hepatotoxicity.
Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides | 1984 |
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
Utilization of preformed and endogenously synthesized methionine by cells in tissue culture.
Topics: Animals; Bone Marrow; Cell Division; Cell Line; Culture Media; Embryo, Mammalian; Homocysteine; Humans; Lung; Methionine; Mice; Neoplasms, Experimental; Tetrahydrofolates | 1984 |
The effect of methotrexate on homocysteine methylating agents in rat liver.
Topics: Animals; Betaine; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Inbred Strains; Tetrahydrofolates; Time Factors | 1982 |
Homocysteinemia and schizophrenia as a case of methylation deficiency.
Topics: Adult; Female; Homocysteine; Humans; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Schizophrenia; Tetrahydrofolates; Vitamin B 12 | 1994 |
The methylfolate axis in neural tube defects: in vitro characterisation and clinical investigation.
Topics: Animals; Anticonvulsants; Female; Folic Acid; Homocysteine; Humans; In Vitro Techniques; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Rats; Rats, Wistar; Tetrahydrofolates | 1994 |
Nitrous oxide inactivation of cobalamin-dependent methionine synthase from Escherichia coli: characterization of the damage to the enzyme and prosthetic group.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Sequence; Binding Sites; Electrochemistry; Escherichia coli; Homocysteine; Methionine; Molecular Sequence Data; Nitrous Oxide; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; S-Adenosylmethionine; Tetrahydrofolates; Trypsin; Vitamin B 12 | 1994 |
Assignment of enzymatic function to specific protein regions of cobalamin-dependent methionine synthase from Escherichia coli.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Binding Sites; Catalysis; Escherichia coli; Homocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 | 1993 |
Low whole-blood S-adenosylmethionine and correlation between 5-methyltetrahydrofolate and homocysteine in coronary artery disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Case-Control Studies; Cohort Studies; Coronary Disease; Erythrocytes; Female; Follow-Up Studies; Homocysteine; Humans; Isoenzymes; Lymphocytes; Male; Methionine Adenosyltransferase; Methylation; Middle Aged; Risk Factors; S-Adenosylmethionine; Tetrahydrofolates | 1996 |
The effect of folic acid on the homocysteine metabolism in human umbilical vein endothelial cells (HUVECs).
Topics: Cells, Cultured; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kinetics; Leucovorin; Tetrahydrofolates; Time Factors; Umbilical Veins | 1996 |
Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy humans.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Kinetics; Male; Methionine; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1996 |
Cobalamin-independent methionine synthase from Escherichia coli: a zinc metalloenzyme.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Binding Sites; Cadmium Chloride; Circular Dichroism; Cloning, Molecular; Cysteine; Escherichia coli; Fourier Analysis; Homocysteine; Metalloproteins; Mutagenesis, Site-Directed; Protein Conformation; Spectrum Analysis; Tetrahydrofolates; Vitamin B 12; X-Rays; Zinc | 1996 |
Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bacterial Proteins; Binding Sites; Escherichia coli; Homocysteine; Methylation; Protein Binding; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 | 1997 |
Methionine synthase from pig liver.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Radioisotopes; Chromatography; Chromatography, Gel; Homocysteine; Hydrogen-Ion Concentration; Liver; Methionine; Molecular Weight; Spectrophotometry; Swine; Tetrahydrofolates | 1997 |
Purification and assay of cobalamin-dependent methionine synthase from Escherichia coli.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Carbon Radioisotopes; Escherichia coli; Homocysteine; Methionine; Spectrophotometry; Tetrahydrofolates; Vitamin B 12 | 1997 |
Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Administration, Oral; Adult; Female; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1997 |
Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Catalysis; Cobalt; Cyclic N-Oxides; Enzyme Activation; Escherichia coli; Ferricyanides; Homocysteine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Oxidation-Reduction; Phenolsulfonphthalein; Photolysis; Protein Binding; Protons; Spectrophotometry; Tetrahydrofolates; Vitamin B 12 | 1997 |
Cobalamin-dependent methionine synthase from Escherichia coli: involvement of zinc in homocysteine activation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Catalysis; Edetic Acid; Escherichia coli; Homocysteine; Methyl Methanesulfonate; Methylation; Mutagenesis; Protein Binding; Protons; Recombinant Proteins; Spectrophotometry; Spectrum Analysis; Tetrahydrofolates; Vitamin B 12; Zinc | 1997 |
Reliability of biochemical parameters used in prenatal diagnosis of combined methylmalonic aciduria and homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Amniocentesis; Amniotic Fluid; Cells, Cultured; Chorion; Chorionic Villi Sampling; Cobamides; Female; Gestational Age; Homocysteine; Homocystinuria; Humans; Male; Methylmalonic Acid; Pregnancy; Propionates; Tetrahydrofolates; Vitamin B 12 | 1998 |
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methionine; Methylation; Phosphatidylcholines; S-Adenosylmethionine; Seizures; Serine; Tetrahydrofolates | 1998 |
The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Age of Onset; Aged; Amino Acid Substitution; Case-Control Studies; Fasting; Female; Folic Acid; Gene Frequency; Genetic Heterogeneity; Homocysteine; Humans; Hyperhomocysteinemia; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Requirements; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Risk Factors; Sex Factors; Tetrahydrofolates; Thrombophilia; Thrombosis; Vitamin B 12; Vitamin B 12 Deficiency | 2000 |
Conversion of 5-formyltetrahydrofolic acid to 5-methyltetrahydrofolic acid is unimpaired in folate-adequate persons homozygous for the C677T mutation in the methylenetetrahydrofolate reductase gene.
Topics: Administration, Oral; Adult; Area Under Curve; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Tetrahydrofolates | 2000 |
Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers.
Topics: Adult; Diet; Folic Acid; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Semen; Smoking; Sperm Count; Spermatozoa; Tetrahydrofolates; Vitamin B 12; Vitamins | 2001 |
Folate protects against oxidative modification of human LDL.
Topics: Catalysis; Copper; Dose-Response Relationship, Drug; Homocysteine; Humans; Lipoproteins, LDL; Oxidation-Reduction; Tetrahydrofolates | 2001 |
Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study.
Topics: Adult; Aged; Case-Control Studies; Erythrocytes; Female; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Pulmonary Embolism; Risk Factors; Tetrahydrofolates; Venous Thrombosis | 2002 |
5-methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis.
Topics: Drug Therapy, Combination; Endothelium, Vascular; Female; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Middle Aged; Renal Dialysis; Tetrahydrofolates; Ultrasonography; Uremia; Vasodilation; Vitamin B 12 | 2002 |
Measurement of red blood cell methylfolate.
Topics: Erythrocytes; Homocysteine; Humans; Tetrahydrofolates; Thromboembolism | 2002 |
Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Substitution; Catalysis; Escherichia coli; Escherichia coli Proteins; Homocysteine; Methionine; Methylation; Mutation, Missense; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Temperature; Tetrahydrofolates; Vitamin B 12 | 2003 |
Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation.
Topics: Cell Transformation, Viral; Cells, Cultured; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Lymphocytes; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Riboflavin; Tetrahydrofolates | 2003 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. IX. TRANSMETHYLATION FROM S-ADENOSYLMETHIONINE AND 5-METHYLTETRAHYDROFOLATE TO 2-MERCAPTOETHANOL AND HOMOCYSTEINE.
Topics: Alkylation; Biological Assay; Carbon Isotopes; Folic Acid; Homocysteine; Kinetics; Lactobacillus; Mercaptoethanol; Methionine; Nucleosides; Research; S-Adenosylmethionine; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolates; Transferases | 1965 |
THE FORMATION OF CH4 FROM N-5-METHYLTETRAHYDROFOLATE MONOGLUTAMATE BY CELL-FREE EXTRACTS OF METHANOBACILLUS OMELIANSKII.
Topics: Adenosine Triphosphate; Autoradiography; Bacteria; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Glutamates; Homocysteine; Methane; Methionine; Research; Spectrophotometry; Tetrahydrofolates; Vitamin B 12 | 1965 |
Hyperhomocystinemia in children with inflammatory bowel disease.
Topics: Adolescent; Aging; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Male; Methylenetetrahydrofolate Reductase (NADPH2); Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Tetrahydrofolates; Thromboembolism; Vitamin B 12; von Willebrand Factor | 2003 |
All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Animals; Dose-Response Relationship, Drug; Glycine N-Methyltransferase; Homocysteine; Liver; Methionine; Methyltransferases; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Tetrahydrofolates; Time Factors; Tretinoin | 2003 |
Folic acid rescues nitric oxide-induced neural tube closure defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Radioisotopes; Chick Embryo; Culture Techniques; Folic Acid; Hemoglobins; Homocysteine; Models, Biological; Neural Tube Defects; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Tetrahydrofolates; Time Factors | 2004 |
Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke.
Topics: Acute Disease; Analysis of Variance; Dietary Supplements; Erythrocytes; Folic Acid; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Stroke; Tetrahydrofolates; Vitamins | 2004 |
Hyperproliferation of homocysteine-treated colon cancer cells is reversed by folate and 5-methyltetrahydrofolate.
Topics: Caco-2 Cells; Cell Cycle; Cell Death; Cell Division; Colonic Neoplasms; Flow Cytometry; Folic Acid; Hematinics; Homocysteine; Humans; In Vitro Techniques; Tetrahydrofolates; Time Factors | 2004 |
Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Arabidopsis; Binding Sites; Cations; Crystallography, X-Ray; Cysteine; Escherichia coli; Folic Acid; Fourier Analysis; Histidine; Homocysteine; Methionine; Methyltransferases; Models, Molecular; Plasmids; Protein Conformation; Protein Structure, Tertiary; Sulfur; Tetrahydrofolates; Vitamin B 12; Zinc | 2004 |
Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Colorectal Neoplasms; DNA Damage; DNA Methylation; Erythrocytes; Female; Folic Acid; Genetic Carrier Screening; Genetic Variation; Genotype; Homocysteine; Homozygote; Humans; Isoenzymes; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk; Scotland; Tetrahydrofolates; Uracil; Vitamin B 12 | 2004 |
Distribution of 5,10-methylenetetrahydrofolate reductase (C667T) polymorphism and its association with red blood cell 5-methyltetrahydrofolate in the healthy Iranians.
Topics: Analysis of Variance; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Iran; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Requirements; Polymorphism, Genetic; Tetrahydrofolates; Vitamin B 12 | 2005 |
Simultaneous quantification of homocysteine and folate in human serum or plasma using liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, Liquid; Folic Acid; Homocysteine; Humans; Molecular Structure; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tetrahydrofolates; Time Factors | 2005 |
Association of red blood cell 5-methyltetrahydrofolate folate with bone mineral density in postmenopausal Iranian women.
Topics: Absorptiometry, Photon; Biomarkers; Body Mass Index; Bone Density; Erythrocytes; Female; Femur Neck; Homocysteine; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal; Population Surveillance; Tetrahydrofolates; Vitamin B 12 | 2005 |
Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype.
Topics: Adult; Age of Onset; Case-Control Studies; Dietary Supplements; Dinoprost; Female; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidative Stress; Tetrahydrofolates; Thrombosis; Thromboxane B2 | 2005 |
Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap.
Topics: Chromatography, Liquid; DNA Methylation; Erythrocytes; Folic Acid; Homocysteine; Homozygote; Humans; Hydroxocobalamin; Male; Mass Spectrometry; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia.
Topics: Adult; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; DNA; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Sulfhydryl Compounds; Tetrahydrofolates; Vitamin B 12; Vitamin E | 2006 |
Patient information. The importance of homocysteine.
Topics: Biological Availability; Cardiovascular Diseases; Causality; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Nurse Practitioners; Risk Reduction Behavior; Tetrahydrofolates | 2006 |
Folate: in vitro and in vivo effects on VLDL and LDL oxidation.
Topics: Antioxidants; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Lipid Peroxidation; Lipoproteins, LDL; Lipoproteins, VLDL; Oxidation-Reduction; Tetrahydrofolates | 2007 |
[Smoking influence on the level of homocysteine and 5-methyltetrahydrofolic acid in active and non smokers].
Topics: Adult; Cotinine; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Smoking; Tetrahydrofolates | 2007 |
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.
Topics: Animals; Brain; Disease Models, Animal; Female; Folic Acid; Genotype; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Survival Rate; Tetrahydrofolates | 2008 |
Commutability of NIST SRM 1955 Homocysteine and Folate in Frozen Human Serum with selected total homocysteine immunoassays and enzymatic assays.
Topics: Blood Chemical Analysis; Chromatography, Liquid; Enzymes; Folic Acid; Freezing; Homocysteine; Humans; Immunoassay; Linear Models; Models, Statistical; Predictive Value of Tests; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tetrahydrofolates; United States | 2008 |
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.
Topics: Aged; Coronary Artery Disease; Endothelium, Vascular; Female; Genotype; Homocysteine; Humans; Male; Mammary Arteries; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nitric Oxide; Oxidation-Reduction; Phenols; Plant Extracts; Polymorphism, Genetic; Saphenous Vein; Superoxides; Tetrahydrofolates | 2009 |
Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Case-Control Studies; Female; Genotype; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Neuropsychological Tests; Peptide Fragments; S-Adenosylmethionine; tau Proteins; Tetrahydrofolates; Young Adult | 2009 |
Quantification of key folate forms in serum using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adolescent; Adult; Carbon Isotopes; Chromatography, High Pressure Liquid; Drug Stability; Female; Folic Acid; Homocysteine; Humans; Linear Models; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tetrahydrofolates | 2010 |
Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse.
Topics: Animals; Folic Acid; Gene Deletion; Homocysteine; Intestinal Absorption; Leucovorin; Male; Mice; Multidrug Resistance-Associated Proteins; Tetrahydrofolates; Vitamin B 12 | 2010 |
Decreased level of 5-methyltetrahydrofolate: a potential biomarker for pre-symptomatic amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Chromatography, Liquid; Disease Models, Animal; Folic Acid; Gene Expression Regulation; Homocysteine; Humans; Mice; Mice, Transgenic; Severity of Illness Index; Statistics as Topic; Superoxide Dismutase; Tandem Mass Spectrometry; Tetrahydrofolates; Time Factors | 2010 |
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors.
Topics: Aged; Aging; Anemia; Anemia, Macrocytic; Blood Cell Count; Cognition; Cognition Disorders; Cystatin C; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Linear Models; Male; Methylmalonic Acid; Multivariate Analysis; Nutrition Surveys; Tetrahydrofolates; United States; Vitamin B 12 Deficiency | 2010 |
Reduced de novo synthesis of 5-methyltetrahydrofolate and reduced taurine levels in ethanol-treated chick brains.
Topics: Animals; Brain; Chick Embryo; Chickens; Ethanol; Homocysteine; Oxidoreductases; Taurine; Tetrahydrofolates | 2010 |
Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United States.
Topics: Aged; Diet; Dietary Supplements; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Nutrition Surveys; Tetrahydrofolates; United States; Vitamin B 12 | 2010 |
Methyl Vitamin B12 but not methylfolate rescues a motor neuron-like cell line from homocysteine-mediated cell death.
Topics: Animals; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Dose-Response Relationship, Drug; Homocysteine; Inhibitory Concentration 50; Mice; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Tetrahydrofolates; Time Factors; Vitamin B 12; Vitamin B Complex | 2011 |
Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study).
Topics: Cohort Studies; Colorectal Neoplasms; Diet; Erythrocytes; Female; Folic Acid; Glutathione Reductase; Homocysteine; Humans; Intestinal Mucosa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Assessment; Nutritional Status; Risk Factors; Surveys and Questionnaires; Tetrahydrofolates; Vitamin B 12 | 2013 |
Involvement of 5-methyltetrahydrofolate in the amelioration of hyperhomocysteinemia caused by vitamin B(6) deficiency and L-methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Dietary Supplements; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Tetrahydrofolates; Vitamin B 6; Vitamin B 6 Deficiency | 2013 |
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil | 2014 |
Quantification of folate metabolites in serum using ultraperformance liquid chromatography tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Limit of Detection; Neural Tube Defects; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolates | 2014 |
Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence.
Topics: Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Ascorbic Acid; Case-Control Studies; Colorectal Neoplasms; Diet; Folic Acid; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Middle Aged; Polymorphism, Single Nucleotide; Pteroylpolyglutamic Acids; Risk Factors; Tetrahydrofolates; Vitamins | 2015 |
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation.
Topics: Aged; Blood Cells; Calcium; Cross-Sectional Studies; Dietary Supplements; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prospective Studies; S-Adenosylhomocysteine; S-Adenosylmethionine; Telomere; Tetrahydrofolates; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin D | 2016 |
Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia.
Topics: Aged; Aryldialkylphosphatase; Case-Control Studies; Dementia; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Interleukin-1beta; Male; Middle Aged; Poland; Polymorphism, Restriction Fragment Length; Tetrahydrofolates; Vitamin B 12 | 2016 |
Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta.
Topics: Adult; Albumins; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Apolipoprotein E4; Female; Folic Acid; Healthy Volunteers; Homocysteine; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Reference Values; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 | 2016 |
5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility.
Topics: Female; Genetic Testing; Heterozygote; Homocysteine; Homozygote; Humans; Infertility; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Tetrahydrofolates | 2020 |
Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats.
Topics: Animals; Cell Count; Corticosterone; Diet; Dose-Response Relationship, Drug; Doublecortin Protein; Female; Fluorescent Antibody Technique; Folic Acid; Hippocampus; Homocysteine; Neurogenesis; Random Allocation; Rats; Sulfathiazoles; Tetrahydrofolates; Time Factors | 2019 |
Normal serum cobalamin levels do not exclude the diagnosis of pernicious anaemia: a case report.
Topics: Anemia, Pernicious; Female; Folic Acid Deficiency; Gastritis, Atrophic; Homocysteine; Humans; Hydroxocobalamin; Methylmalonic Acid; Middle Aged; Tetrahydrofolates; Vitamin B 12; Vitamin B Complex | 2020 |
Determination of plasma homocysteine with a UHPLC-MS/MS method: Application to analyze the correlation between plasma homocysteine and whole blood 5-methyltetrahydrofolate in healthy volunteers.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Homocysteine; Humans; Limit of Detection; Linear Models; Male; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrofolates; Young Adult | 2020 |
A pilot study to assess the effect of a three-month vitamin supplementation containing L-methylfolate on systemic homocysteine plasma concentrations and retinal blood flow in patients with diabetes.
Topics: Adolescent; Adult; Aged; Blood Circulation; Diabetes Mellitus; Dietary Supplements; Female; Homocysteine; Humans; Male; Middle Aged; Pilot Projects; Retina; Retinal Vessels; Tetrahydrofolates; Tomography, Optical Coherence; Vitamin B 12; Vitamins | 2020 |
Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women.
Topics: Adult; Asian People; Female; Fetal Blood; Folic Acid; Homocysteine; Humans; Japan; Longitudinal Studies; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnant Women; Prospective Studies; Tetrahydrofolates; Young Adult | 2020 |
Simultaneous quantification of intracellular concentrations of clinically important metabolites of folate-homocysteine cycle by LC-MS/MS.
Topics: Cell Line; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Humans; Tandem Mass Spectrometry; Tetrahydrofolates | 2020 |
Four families of folate-independent methionine synthases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Archaeal Proteins; Bacterial Proteins; Biosynthetic Pathways; Folic Acid; Homocysteine; Iron-Sulfur Proteins; Methionine; Models, Chemical; Molecular Structure; Multigene Family; Oxygen; Tetrahydrofolates; Vitamin B 12 | 2021 |
Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women.
Topics: Adolescent; Adult; Cesarean Section; Cross-Sectional Studies; Depression, Postpartum; Diet; Female; Homocysteine; Humans; India; Methylmalonic Acid; Pregnancy; Pregnancy, Unplanned; Risk Factors; S-Adenosylmethionine; Serotonin; Social Class; Tetrahydrofolates; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult | 2021 |
A comprehensive study of the genotoxic and anti-genotoxic effects of homocysteine in HUVECs and mouse bone marrow cells.
Topics: Animals; Bone Marrow Cells; Copper; Dose-Response Relationship, Drug; Gene Expression Regulation; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Iron; Male; Mice; Mutagenicity Tests; Tetrahydrofolates; Vitamin B 6 | 2021 |
5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology.
Topics: Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infertility, Female; Live Birth; Pregnancy; Reproductive Techniques, Assisted; Retrospective Studies; Tetrahydrofolates; Vitamin B 12; Vitamin B Complex | 2021 |
Quantitation of 5-Methyltetrahydrofolate in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry.
Topics: Chromatography, Liquid; DNA; Folic Acid; Homocysteine; Isotopes; Lipids; RNA; Tandem Mass Spectrometry; Tetrahydrofolates | 2022 |
Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women.
Topics: Adolescent; Adult; Betaine; Carbon; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Pregnancy; S-Adenosylmethionine; Young Adult | 2023 |
The effects of folinic acid and l-methylfolate supplementation on serum total homocysteine levels in healthy adults.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged | 2023 |