holothurin has been researched along with cucumarioside* in 2 studies
2 other study(ies) available for holothurin and cucumarioside
| Article | Year |
|---|---|
Hemolytic activities of triterpene glycosides from the holothurian order Dendrochirotida: some trends in the evolution of this group of toxins.
Hemolysis and K+ loss from mouse erythrocytes, induced by triterpene glycosides and their derivatives from this order of sea cucumbers were studied. Sulfate groups, attached to position 4 of the first xylose residue and to position 6 of the third glucose residue of the branched pentaosides, having 3-O-methyl-groups in terminal monosaccharide moieties increase K+ loss. A sulfate group at C-4 of the first xylose residue increases the hemolytic activity while a sulfate at C-6 of the third monosaccharide unit decreases it. A sulfate group at C-6 of terminal 3-O-methylglucose drastically decreases the hemolytic activity and rate of K+ loss. The presence of a sulfate group at the first xylose residue in glycosides having no 3-O-methyl group at the terminal monosaccharide decreases hemolytic activity and rate of K+ loss. The presence of the 16-ketone group in aglycones having the 7(8)-double bond significantly decreases activity. These results correlate with the previously proposed trends in evolution of sea cucumber glycosides from substances having sulfate groups at C-6 of glucose and 3-O-methylglucose units to substances sulfated at C-4 of the first xylose or having no sulfate groups, and from substances with aglycone 16-ketone to substances having no oxygen functions in this position. Topics: 3-O-Methylglucose; Animals; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Erythrocytes; Glycosides; Hemolysis; Holothurin; Lethal Dose 50; Magnetic Resonance Spectroscopy; Marine Toxins; Mice; Potassium; Sea Cucumbers; Structure-Activity Relationship; Sulfates; Triterpenes | 1996 |
[Cytogenetic study of the mutagenicity of cucumarioside].
Mutagenic activity of cucumarioside displaying strong immunomodulating effect was studied. Two cytogenetic tests--mouse bone marrow micronucleus assay and the method for analysis of chromosomal aberrations--were used to evaluate mutagenic activity. Both tests demonstrated negative mutagenic effect. Topics: Animals; Bone Marrow; Chromosome Aberrations; Glycosides; Holothurin; Mice; Micronucleus Tests; Mutagens; Sea Cucumbers; Triterpenes | 1990 |