hoe-777 and didecyldimethylammonium

Topics: Administration, Cutaneous; Adult; Anti-Infective Agents; Dermatitis, Atopic; Double-Blind Method; Drug Combinations; Female; Humans; Male; Prednisolone; Quaternary Ammonium Compounds; Staphylococcal Skin Infections; Treatment Outcome

After a brief account of the therapeutic problems with microbially superinfected eczemas, the results of a double-blind study of hospitalized patients are reported. Two concentrations of the antibacterial agent Bardac-22 (didecyl-dimethyl-ammonium chloride. Hoe S 2922) in combination with the steroid prednicarbate (prednisolone 17-(ethylcarbonate)-21-propionate, Hoe 777) were used. The quantitative determination of cutaneous bacteria was performed by a modified method of Faergemann. The double blind study did not reveal any significant differences in effectiveness, although a trend in favour of the higher concentration was apparent.

Topics: Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Eczema; Female; Humans; Impetigo; Male; Middle Aged; Prednisolone; Quaternary Ammonium Compounds