Page last updated: 2024-09-03

hoe 694 and amiloride

hoe 694 has been researched along with amiloride in 52 studies

Compound Research Comparison

Studies
(hoe 694)
Trials
(hoe 694)
Recent Studies (post-2010)
(hoe 694)
Studies
(amiloride)
Trials
(amiloride)
Recent Studies (post-2010) (amiloride)
120047,584339788

Protein Interaction Comparison

ProteinTaxonomyhoe 694 (IC50)amiloride (IC50)
Urokinase-type plasminogen activatorHomo sapiens (human)4.7
Urokinase-type plasminogen activatorMus musculus (house mouse)2.3
Amine oxidase [flavin-containing] AHomo sapiens (human)3.909
Sodium/hydrogen exchanger 1Rattus norvegicus (Norway rat)1
Amiloride-sensitive sodium channel subunit alphaHomo sapiens (human)0.776
Sodium/hydrogen exchanger 2Oryctolagus cuniculus (rabbit)1
Acid-sensing ion channel 3Homo sapiens (human)4.4

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's30 (57.69)18.2507
2000's20 (38.46)29.6817
2010's2 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lang, HJ; Popp, R; Schmid, A; Scholz, W1
du Toit, EF; Opie, LH1
Burckhardt, BC; Busch, S; Siffert, W1
Avkiran, M; Hearse, DJ; Ibuki, C; Yasutake, M1
Flameng, W; Hendrikx, M; Lauweryns, J; Mubagwa, K; Overloop, K; Van Hecke, P; Van Lommel, A; Vanstapel, F; Verbeken, E; Verdonck, F1
Counillon, L; Lang, HJ; Pouysségur, J; Scholz, W1
Albus, U; Englert, HC; Lang, HJ; Linz, W; Martorana, PA; Schölkens, BA; Scholz, W1
Kranzhöfer, R; Kübler, W; Lang, HJ; Metz, J; Pestel, E; Schirmer, J; Schömig, A; von Hodenberg, E1
Kandasamy, RA; Orlowski, J1
Avkiran, M; Hearse, DJ; Shimada, Y1
Liu, J; Shiga, N; Wangemann, P1
Loh, SH; Sun, B; Vaughan-Jones, RD1
Ko, Y; Sachinidis, A; Seewald, S; Seul, C; Vetter, H1
Bril, A; Khandoudi, N; Laville, MP1
John, GW; Le Grand, B; Marty, A; Talmant, JM1
Counillon, L; Noël, J; Pouysségur, J; Reithmeier, RA1
Brew, BK; Cook, DI; Field, MJ; Györy, AZ; Johnson, DW; Pollock, CA; Poronnik, P1
Faber, S; Jansen, HW; Lang, HJ; Scholz, W; Weichert, A1
Casavola, V; Di Sole, F; Guerra, L; Perlino, E; Reshkin, SJ; Ronco, PM; Valenti, G1
D'Souza, SJ; Gan, BS; Grinstein, S; Orlowski, J; Shrode, LD1
Banerjee, A; Cain, BS; Cleveland, JC; Harken, AH; Meldrum, DR; Rehring, TF; Shapiro, JI1
Frishman, WH; Gurell, D; Levitsky, J1
Lee, CO; Woo, SH1
Aharonovitz, O; Demaurex, N; Grinstein, S; Woodside, M1
de Medina, FS; Donowitz, M; Janecki, AJ; Montrose, MH; Tse, CM; Zweibaum, A1
Karmazyn, M1
Gu, XQ; Haddad, GG; Ma, E; Yao, H1
Drumm, K; Freudinger, R; Gassner, B; Gekle, M; Mildenberger, S; Silbernagl, S1
Chow, CW1
Good, DW; Watts, BA1
Numata, M; Orlowski, J; Shull, GE; Szabó, EZ1
Baum, M; Choi, JY; Lee, MG; Muallem, S; Schultheis, PJ; Shah, M; Shull, GE1
Alper, SL; Klein, M; Schuricht, B; Schwab, A; Seeger, P1
Chattou, S; Coulombe, A; Diacono, J; Feuvray, D; John, G; Le Grand, B1
Browning, JA; Wilkins, RJ; Yamazaki, N1
Aschenbach, JR; Gäbel, G; Müller, F1
Alli, HA; Angle, JM; Black, ED; Donowitz, M; Madara, JL; Tse, CM; Turner, JR; Uchwat, FA; Ward, J1
Chew, SB; Leung, GP; Tse, CM; Wong, PY1
Binder, HJ; Geibel, J; Rajendran, VM1
Abedin, MZ; Abedin, ZR; Giurgiu, DI; Peck, EA; Smith, PR; Su, X1
Duquette, RA; Wray, S1
Drumm, K; Gassner, B; Gekle, M; Silbernagl, S1
Aronson, PS; Giebisch, G; Hropot, M; Wang, T1
Cook, DI; Day, ML; Gibb, CA; Harding, EA; Johnson, MH1
Galvez, F; Goss, GG; Hawkings, GS; Reid, SD1
Duranton, C; Huber, SM; Lang, F; Lang, KS; Myssina, S; Tanneur, V; Wieder, T1
Germain, D; Noël, J; Vadnais, J1
Browning, JA; Wilkins, RJ1
Cala, PM; King, SA; Nygaard, EB; Pedersen, SF; Rigor, RR1
Demaurex, N; Park, KS; Poburko, D; Wollheim, CB1
Alexander, T; Grinstein, S; Hahn, KM; Hayashi, H; Kim, M; Koivusalo, M; Scott, CC; Touret, N; Welch, C1
Martens, H; Noci, B; Rabbani, I; Siegling-Vlitakis, C1

Reviews

3 review(s) available for hoe 694 and amiloride

ArticleYear
Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:10

    Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Diuretics; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones

1998
Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition.
    Journal of thrombosis and thrombolysis, 1999, Volume: 8, Issue:1

    Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Diuretics; Guanidines; Humans; Myocardial Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones

1999
Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1999, Volume: 22, Issue:5

    Topics: Adenosine Triphosphate; Amiloride; Animals; Cimetidine; Clonidine; Epithelial Cells; Guanidines; Ion Transport; Kidney; Phosphorylation; Protein Isoforms; Sodium-Hydrogen Exchangers; Sulfones

1999

Other Studies

49 other study(ies) available for hoe 694 and amiloride

ArticleYear
Na+/H+ exchange in porcine cerebral capillary endothelial cells is inhibited by a benzoylguanidine derivative.
    Biochemical and biophysical research communications, 1992, Apr-15, Volume: 184, Issue:1

    Topics: Amiloride; Animals; Capillaries; Carrier Proteins; Cells, Cultured; Cerebrovascular Circulation; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; Guanidines; Hydrogen-Ion Concentration; Kinetics; Sodium; Sodium-Hydrogen Exchangers; Sulfones; Swine

1992
Role for the Na+/H+ exchanger in reperfusion stunning in isolated perfused rat heart.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:6

    Topics: Amiloride; Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Coronary Circulation; Electrolytes; Guanidines; In Vitro Techniques; Myocardial Stunning; Rats; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones

1993
Expression of the human sodium/proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium/proton exchange activity and establishes sodium/lithium countertransport.
    Pflugers Archiv : European journal of physiology, 1995, Volume: 429, Issue:6

    Topics: Amiloride; Ammonium Chloride; Animals; Antiporters; Female; Gene Expression; Gene Transfer Techniques; Guanidines; Humans; Hydrogen-Ion Concentration; Kinetics; Lithium; Nickel; Oocytes; Phloretin; RNA, Complementary; Sodium; Sodium-Hydrogen Exchangers; Sulfones; Xenopus laevis

1995
Na+/H+ exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor.
    The American journal of physiology, 1994, Volume: 267, Issue:6 Pt 2

    Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Circulation; Electrocardiography; Guanidines; Heart Rate; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones; Ventricular Fibrillation

1994
New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart.
    Circulation, 1994, Volume: 89, Issue:6

    Topics: Adenosine Triphosphate; Amiloride; Animals; Calcium; Female; Guanidines; Hemodynamics; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Perfusion; Rabbits; Sodium-Hydrogen Exchangers; Sulfones

1994
Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.
    Molecular pharmacology, 1993, Volume: 44, Issue:5

    Topics: Amiloride; Animals; Cell Line; Cricetinae; Cricetulus; DNA, Complementary; Guanidines; Myocardial Ischemia; Recombinant Proteins; Sodium-Hydrogen Exchangers; Sulfones; Transfection

1993
Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia.
    British journal of pharmacology, 1993, Volume: 109, Issue:2

    Topics: Adenosine Triphosphate; Amiloride; Anesthesia; Animals; Blood Platelets; Cattle; Endothelium, Vascular; Erythrocyte Membrane; Female; Glycogen; Guanidines; In Vitro Techniques; Ion Exchange; Male; Myocardial Ischemia; Phosphocreatine; Potassium; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sodium; Sulfones

1993
Suppression of neointimal thickening and smooth muscle cell proliferation after arterial injury in the rat by inhibitors of Na(+)-H+ exchange.
    Circulation research, 1993, Volume: 73, Issue:2

    Topics: Amiloride; Animals; Arteries; Carrier Proteins; Catheterization; Cell Division; Guanidines; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones; Wounds, Nonpenetrating

1993
Delineation of transmembrane domains of the Na+/H+ exchanger that confer sensitivity to pharmacological antagonists.
    The Journal of biological chemistry, 1996, Aug-16, Volume: 271, Issue:33

    Topics: Amiloride; Animals; Biological Transport; Cimetidine; DNA, Complementary; Enzyme Inhibitors; Guanidines; Kinetics; Ligands; Membrane Glycoproteins; Rats; Recombinant Fusion Proteins; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Sulfones

1996
Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors.
    The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 2

    Topics: Amiloride; Animals; Bicarbonates; Buffers; Dose-Response Relationship, Drug; Extracellular Space; Guanidines; Heart; HEPES; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones

1996
Vestibular dark cells contain the Na+/H+ exchanger NHE-1 in the basolateral membrane.
    Hearing research, 1996, Volume: 94, Issue:1-2

    Topics: Amiloride; Animals; Basilar Membrane; Cell Size; Corpus Striatum; Diuretics; Epithelium; Fluoresceins; Fluorescent Dyes; Fluorometry; Gerbillinae; Guanidines; Hydrogen-Ion Concentration; Propionates; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Sulfones; Vestibule, Labyrinth

1996
Effect of Hoe 694, a novel Na(+)-H+ exchange inhibitor, on intracellular pH regulation in the guinea-pig ventricular myocyte.
    British journal of pharmacology, 1996, Volume: 118, Issue:8

    Topics: Amiloride; Animals; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Heart; Hydrogen-Ion Concentration; Sodium-Hydrogen Exchangers; Sulfones

1996
Activation of Na+/H+ exchanger is not involved in the PDGF-BB-induced DNA-synthesis in vascular smooth muscle cells.
    Biochemical and biophysical research communications, 1996, Oct-14, Volume: 227, Issue:2

    Topics: Amiloride; Animals; Aorta, Thoracic; Becaplermin; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Guanidines; Hydrogen-Ion Concentration; Kinetics; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred WKY; Recombinant Proteins; Sodium; Sodium-Hydrogen Exchangers; Sulfones

1996
Protective effect of the sodium/hydrogen exchange inhibitors during global low-flow ischemia.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:4

    Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Cardiac Output; Energy Metabolism; Guanidines; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Sulfones

1996
HOE 694 affords protection versus veratrine contractures in rat atria by Na+ channel blockade.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:5

    Topics: Action Potentials; Algorithms; Amiloride; Animals; Diuretics; Dose-Response Relationship, Drug; Guanidines; Heart Atria; Lethal Dose 50; Male; Myocardial Contraction; Rats; Rats, Wistar; Sodium Channels; Sodium-Hydrogen Exchangers; Sulfones; Veratrine

1996
Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1.
    Biochemistry, 1997, Mar-11, Volume: 36, Issue:10

    Topics: Amiloride; Binding Sites; Clone Cells; Cloning, Molecular; DNA, Complementary; Drug Resistance; Fibroblasts; Guanidines; Humans; Membrane Proteins; Mutagenesis; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Sodium; Sodium-Hydrogen Exchangers; Sulfones

1997
Insulin-like growth factor I stimulates apical sodium/hydrogen exchange in human proximal tubule cells.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2

    Topics: Adult; Amiloride; Cell Division; Cells, Cultured; Culture Media, Serum-Free; DNA; Female; Fluoresceins; Fluorescent Dyes; Guanidines; Humans; Insulin-Like Growth Factor I; Kidney Tubules, Proximal; Kinetics; Male; Middle Aged; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Sulfones; Thymidine

1997
Synthesis of the highly selective Na+/H+ exchange inhibitors cariporide mesilate and (3-methanesulfonyl-4-piperidino-benzoyl) guanidine methanesulfonate.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:11

    Topics: Amiloride; Cell Line; Diuretics; Enzyme Inhibitors; Guanidines; Sodium-Hydrogen Exchangers; Sulfones

1997
Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells.
    Kidney international, 1998, Volume: 53, Issue:5

    Topics: Amiloride; Animals; Base Sequence; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Clonidine; DNA Primers; Guanidines; Hydrogen-Ion Concentration; Intracellular Fluid; Kidney Tubules, Collecting; Kinetics; Polymerase Chain Reaction; Protein Kinases; Rabbits; Sodium-Hydrogen Exchangers; Sulfones

1998
Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage.
    The American journal of physiology, 1998, Volume: 275, Issue:2

    Topics: Amiloride; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blood Platelets; Carbohydrates; Cell Membrane; Chymotrypsin; Cytosol; Guanidines; Humans; Kinetics; Models, Molecular; Peptide Mapping; Protein Folding; Protein Structure, Secondary; Rats; Recombinant Fusion Proteins; Sodium-Hydrogen Exchangers; Sulfones; Transfection

1998
Mechanisms of pH preservation during global ischemia in preconditioned rat heart: roles for PKC and NHE.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: Acidosis; Adenosine Triphosphate; Adrenergic alpha-Agonists; Amiloride; Animals; Guanidines; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Kinetics; Male; Myocardial Ischemia; Phenylephrine; Phosphates; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfones

1998
Effects of endothelin-1 on Ca2+ signaling in guinea-pig ventricular myocytes: role of protein kinase C.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:3

    Topics: Amiloride; Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Electrophysiology; Endothelin-1; Enzyme Inhibitors; Guanidines; Guinea Pigs; Indoles; Male; Maleimides; Myocardial Contraction; Myocardium; Perfusion; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sulfones; Time Factors; Virulence Factors, Bordetella

1999
ATP dependence is not an intrinsic property of Na+/H+ exchanger NHE1: requirement for an ancillary factor.
    The American journal of physiology, 1999, Volume: 276, Issue:6

    Topics: Acids; Adenosine Triphosphate; Amiloride; Animals; Dogs; Erythrocyte Membrane; Erythrocytes; Guanidines; Hydrogen-Ion Concentration; Sodium-Hydrogen Exchangers; Sulfones

1999
Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of caco-2 cells.
    The American journal of physiology, 1999, Volume: 277, Issue:2

    Topics: Amiloride; Biotin; Blotting, Western; Caco-2 Cells; Cell Membrane; Clone Cells; Epidermal Growth Factor; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Guanidines; Humans; Intracellular Membranes; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Tetradecanoylphorbol Acetate

1999
Intracellular pH regulation of CA1 neurons in Na(+)/H(+) isoform 1 mutant mice.
    The Journal of clinical investigation, 1999, Volume: 104, Issue:5

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Ammonium Chloride; Animals; Ataxia; Benzopyrans; Bicarbonates; Carbon Dioxide; Coloring Agents; Guanidines; Hydrogen-Ion Concentration; Intracellular Fluid; Ion Transport; Mice; Mice, Knockout; Mice, Neurologic Mutants; Microscopy, Confocal; Naphthols; Neurons; Protein Isoforms; Protons; Rhodamines; Sodium; Sodium-Hydrogen Exchangers; Sulfones

1999
Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum.
    The Journal of physiology, 1999, Nov-01, Volume: 520 Pt 3

    Topics: Amiloride; Animals; Binding Sites; Cell Membrane; Cytosol; Endocytosis; Endosomes; Epithelial Cells; Guanidines; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Lysosomes; Opossums; Propionates; Receptors, Cell Surface; Serum Albumin; Sodium; Sodium-Hydrogen Exchangers; Sulfones

1999
Hyposmolality stimulates apical membrane Na(+)/H(+) exchange and HCO(3)(-) absorption in renal thick ascending limb.
    The Journal of clinical investigation, 1999, Volume: 104, Issue:11

    Topics: Amiloride; Animals; Benzoquinones; Bicarbonates; Enzyme Inhibitors; Furosemide; Genistein; Guanidines; Lactams, Macrocyclic; Loop of Henle; Male; Mannitol; Osmolar Concentration; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Signal Transduction; Sodium Chloride; Sodium-Hydrogen Exchangers; Sulfones

1999
Kinetic and pharmacological properties of human brain Na(+)/H(+) exchanger isoform 5 stably expressed in Chinese hamster ovary cells.
    The Journal of biological chemistry, 2000, Mar-03, Volume: 275, Issue:9

    Topics: Adenosine Triphosphate; Amiloride; Animals; Brain; CHO Cells; Cimetidine; Cricetinae; Guanidines; Harmaline; Humans; Hydrogen-Ion Concentration; Kinetics; Lithium; Membrane Proteins; Potassium; Protein Isoforms; Sodium Radioisotopes; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Transfection

2000
Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule.
    The Journal of clinical investigation, 2000, Volume: 105, Issue:8

    Topics: Amiloride; Animals; Guanidines; Kidney Tubules, Proximal; Mice; Mice, Inbred C57BL; Mice, Knockout; Protons; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones

2000
Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells.
    The Journal of general physiology, 2000, Volume: 115, Issue:5

    Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Antiporters; Biological Transport; Cell Line; Cell Movement; Cell Polarity; Cell Size; Chloride-Bicarbonate Antiporters; Dogs; Epithelial Cells; Guanidines; Hydrogen-Ion Concentration; Intercellular Signaling Peptides and Proteins; Kidney; Osmotic Pressure; Peptides; Salts; Sodium-Hydrogen Exchangers; Spider Venoms; Sulfones; Water

2000
Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na(+)-H(+)Exchange blockers.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:7

    Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Guanidines; Heart Ventricles; Lysophosphatidylcholines; Male; Myocardium; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channels; Sodium-Hydrogen Exchangers; Streptozocin; Sulfones; Tetrodotoxin; Veratrine

2000
Modulation of Na(+) x H(+) exchange by osmotic shock in isolated bovinearticular chondrocytes.
    Acta physiologica Scandinavica, 2000, Volume: 169, Issue:3

    Topics: Amiloride; Animals; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Fluoresceins; Guanidines; Hydrogen-Ion Concentration; Intracellular Fluid; Meglumine; Myosin-Light-Chain Kinase; Osmolar Concentration; Osmotic Pressure; Protein Kinase C; Quaternary Ammonium Compounds; Sodium; Sodium-Hydrogen Exchangers; Sucrose; Sulfones

2000
Role of Na+/H+ exchange and HCO3- transport in pHi recovery from intracellular acid load in cultured epithelial cells of sheep rumen.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2000, Volume: 170, Issue:4

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acidosis; Amiloride; Animals; Anti-Arrhythmia Agents; Bicarbonates; Biological Transport; Butyrates; Carbon Dioxide; Cell Culture Techniques; Cells, Cultured; Epithelial Cells; Fluoresceins; Guanidines; Hydrogen-Ion Concentration; Rumen; Sheep; Sodium-Hydrogen Exchangers; Sulfones

2000
Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3.
    American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6

    Topics: Acids; Alkalies; Amiloride; Animals; Anti-Ulcer Agents; Antihypertensive Agents; Biological Transport; Caco-2 Cells; Cimetidine; Clonidine; Cytoplasm; Diuretics; Electric Impedance; Electrophysiology; Epithelial Cells; Glucose; Guanidines; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Methacrylates; Microvilli; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Tight Junctions

2000
Expression of multiple Na+/H+ exchanger isoforms in cultured epithelial cells from rat efferent duct and cauda epididymidis.
    Biology of reproduction, 2001, Volume: 64, Issue:2

    Topics: Amiloride; Animals; Blotting, Western; Cell Membrane; Cells, Cultured; Diuretics; Epididymis; Epithelial Cells; Guanidines; Immunohistochemistry; Isoenzymes; Male; Methacrylates; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Seminiferous Tubules; Sodium-Hydrogen Exchangers; Sulfones

2001
Characterization of apical membrane Cl-dependent Na/H exchange in crypt cells of rat distal colon.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:3

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Cell Membrane; Chloride Channels; Chlorides; Colon; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Guanidines; Intestinal Mucosa; Ion Transport; Nitrobenzoates; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Sulfones

2001
Characterization of NA+/H+ exchanger isoform (NHE1, NH32 and NHE3) expression in prairie dog gallbladder.
    The Journal of membrane biology, 2001, Jul-15, Volume: 182, Issue:2

    Topics: Amiloride; Animals; Biological Transport, Active; Blotting, Northern; Cholelithiasis; Disease Models, Animal; Electrophysiology; Epithelial Cells; Gallbladder; Guanidines; Immunoblotting; Male; Protein Isoforms; RNA; Sciuridae; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones

2001
pH regulation and buffering power in gastric smooth muscle.
    Pflugers Archiv : European journal of physiology, 2001, Volume: 442, Issue:3

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acid-Base Equilibrium; Amiloride; Animals; Anti-Arrhythmia Agents; Buffers; Butyrates; Diuretics; Gastric Emptying; Gastric Mucosa; Guanidines; Guinea Pigs; Hydrogen-Ion Concentration; Methylamines; Muscle, Smooth; Rats; Sodium; Sulfones

2001
Inhibition of Na superset+/H superset+ exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells).
    European journal of medical research, 2001, Oct-29, Volume: 6, Issue:10

    Topics: Amiloride; Animals; Cell Line; Chlorpromazine; DNA; Endocytosis; Guanidines; Kidney Tubules, Proximal; LLC-PK1 Cells; NF-kappa B; Opossums; Serum Albumin, Bovine; Sodium-Hydrogen Exchangers; Sulfones; Swine; Tetradecanoylphorbol Acetate

2001
Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron.
    American journal of physiology. Renal physiology, 2001, Volume: 281, Issue:6

    Topics: Absorption; Amiloride; Animals; Bicarbonates; Biological Transport; Culture Techniques; Guanidines; Kidney Tubules, Distal; Kidney Tubules, Proximal; Loop of Henle; Male; Methacrylates; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones

2001
Developmental changes in the management of acid loads during preimplantation mouse development.
    Biology of reproduction, 2002, Volume: 67, Issue:5

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acids; Amiloride; Animals; Blastocyst; Embryonic Development; Female; Guanidines; Hydrogen; Ion Transport; Lithium; Mice; Mice, Inbred Strains; Oocytes; Pregnancy; Protein Isoforms; Sodium-Hydrogen Exchangers; Sulfones; Trophoblasts; Zinc

2002
Localization and characterization of phenamil-sensitive Na+ influx in isolated rainbow trout gill epithelial cells.
    The Journal of experimental biology, 2003, Volume: 206, Issue:Pt 3

    Topics: Amiloride; Animals; Anti-Bacterial Agents; Biological Transport; Bumetanide; Epithelial Cells; Female; Gills; Guanidines; Hydrogen-Ion Concentration; Macrolides; Male; Mitochondria; Models, Biological; Oncorhynchus mykiss; Ouabain; Peanut Agglutinin; Sodium; Sodium Radioisotopes; Sulfones

2003
Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:4

    Topics: Amiloride; Annexins; Apoptosis; Cations; Cell Size; Dose-Response Relationship, Drug; Erythrocytes; Guanidines; Humans; In Vitro Techniques; Ion Channels; Osmotic Pressure; Patch-Clamp Techniques; Sulfones

2003
Glutamate 346 of human Na+-H+ exchanger NHE1 is crucial for modulating both the affinity for Na+ and the interaction with amiloride derivatives.
    Biochemistry, 2003, Dec-30, Volume: 42, Issue:51

    Topics: Amiloride; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Cricetinae; Drug Resistance; Genetic Variation; Glutamic Acid; Guanidines; Humans; Mutagenesis, Site-Directed; Potassium; Protons; RNA, Messenger; Sodium; Sodium-Hydrogen Exchangers; Sulfones

2003
Mechanisms contributing to intracellular pH homeostasis in an immortalised human chondrocyte cell line.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2004, Volume: 137, Issue:2

    Topics: Acidosis; Amiloride; Bicarbonates; Buffers; Cell Line; Chondrocytes; Guanidines; HEPES; Homeostasis; Humans; Hydrogen-Ion Concentration; Sodium; Sulfones

2004
NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.
    The Journal of biological chemistry, 2007, Jul-06, Volume: 282, Issue:27

    Topics: Amiloride; Animals; Binding Sites; Cation Transport Proteins; Cell Line; Cricetinae; Cricetulus; Flounder; Guanidines; Humans; Mutation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sodium Channel Blockers; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Species Specificity; Sulfones; Urodela

2007
Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells.
    British journal of pharmacology, 2009, Volume: 156, Issue:8

    Topics: Amiloride; Antigens, Differentiation; Apoptosis; Calcium; Cell Cycle Proteins; Diuretics; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endothelial Cells; Enzyme Inhibitors; Guanidines; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Protein Phosphatase 1; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Hydrogen Exchangers; Sulfones; Thapsigargin; Transcription Factor CHOP; Transcription, Genetic

2009
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling.
    The Journal of cell biology, 2010, Feb-22, Volume: 188, Issue:4

    Topics: Actin Depolymerizing Factors; Amiloride; Animals; cdc42 GTP-Binding Protein; Cell Line; Cytosol; Enzyme Activation; Epidermal Growth Factor; GRB2 Adaptor Protein; Guanidines; Humans; Hydrogen-Ion Concentration; Hydrolysis; Intracellular Membranes; Phosphorylation; Pinocytosis; Proto-Oncogene Proteins c-akt; Rabbits; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers; Sulfones

2010
Evidence for NHE3-mediated Na transport in sheep and bovine forestomach.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 301, Issue:2

    Topics: Amiloride; Animals; Cattle; Epithelium; Guanidines; Protein Isoforms; Rumen; Sheep; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones

2011