hns-32 has been researched along with azulene* in 1 studies
1 other study(ies) available for hns-32 and azulene
| Article | Year |
|---|---|
Cardiovascular effects of orally administered HNS-32, an originally synthesized azulene-1-carboxamidine derivative, assessed in the in vivo rat model.
HNS-32, an azulene-1-carboxamidine derivative, is an originally synthesized antiarrhythmic compound. Its cardiovascular effects after oral administration (1-10 mg/kg) were assessed using the pentobarbital-anesthetized in vivo rat model in comparison with those of verapamil (3 mg/kg, p.o.). Verapamil decreased the heart rate and mean blood pressure and prolonged the PR interval without changing the QRS width (n = 6). Similar results were observed for HNS-32 except that the QRS width was prolonged by the highest dose and the effects occurred slowly and lasted longer. These results suggest that HNS-32 is an orally active slowly-acting calcium plus sodium channel blocker. Topics: Administration, Oral; Animals; Azulenes; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Cycloheptanes; Electrocardiography; Heart Rate; Male; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers | 2002 |