Compounds > hmr 1766
Page last updated: 2024-09-05

hmr 1766 and cyclic gmp

hmr 1766 has been researched along with cyclic gmp in 5 studies

Compound Research Comparison

Studies
(hmr 1766)		Trials
(hmr 1766)		Recent Studies (post-2010)
(hmr 1766)		Studies
(cyclic gmp)		Trials
(cyclic gmp)		Recent Studies (post-2010) (cyclic gmp)
2311122,3463334,062

Protein Interaction Comparison

ProteinTaxonomyhmr 1766 (IC50)cyclic gmp (IC50)
Phosphodiesterase Bos taurus (cattle)0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)2.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)2.4

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bauersachs, J; Eigenthaler, M; Ertl, G; Flierl, U; Kobsar, A; Schäfer, A1
Dalkas, G; Kotanidou, A; Papapetropoulos, A; Pyriochou, A; Roussos, C; Spyroulias, G; van Eickels, M; Zhou, Z1
Abdallah, Y; Gligorievski, D; Kasseckert, SA; Kluger, A; Noll, T; Piper, HM; Sauer, H; Schäfer, C; Schlüter, KD; Tillmann, J1
Dahal, BK; Dumitrascu, R; Eickels, Mv; Fuchs, B; Ghofrani, HA; Grimminger, F; Hackemack, S; Medebach, T; Mittal, M; Pullamsetti, SS; Savai, R; Schermuly, RT; Seeger, W; Weissmann, N1
Martinelli, AM; Moraes, TF; Rodrigues, CNDS; Rodrigues, GJ1

Other Studies

5 other study(ies) available for hmr 1766 and cyclic gmp

ArticleYear
Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic rats.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:12

    Topics: Animals; Blood Platelets; Cell Adhesion Molecules; Cyclic GMP; Diabetes Mellitus, Experimental; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Male; Microfilament Proteins; Nitric Oxide; ortho-Aminobenzoates; Phosphoproteins; Platelet Activation; Platelet Aggregation; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Sulfonamides; Thrombosis

2006
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4

    Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Male; Models, Molecular; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; ortho-Aminobenzoates; Oxidants; Oxidative Stress; Protein Conformation; Protein Structure, Tertiary; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Sulfonamides; Transfection; Vasodilator Agents

2008
Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation.
    Cardiovascular research, 2009, Jul-15, Volume: 83, Issue:2

    Topics: Animals; Calcium; Calcium-Binding Proteins; Carbazoles; Cell Hypoxia; Cells, Cultured; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Edema, Cardiac; Endoplasmic Reticulum; Endothelial Cells; Enzyme Activators; Gap Junctions; Guanylate Cyclase; Homeostasis; Hydrazines; Male; Myocardial Reperfusion Injury; Myosin Light Chains; ortho-Aminobenzoates; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Second Messenger Systems; Soluble Guanylyl Cyclase; Sulfonamides; Time Factors

2009
The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 297, Issue:4

    Topics: Animals; Cardiomegaly; Cyclic GMP; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Mice; Myocytes, Smooth Muscle; ortho-Aminobenzoates; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Sulfonamides; Superoxides; Vasoconstriction

2009
In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2018, Volume: 21, Issue:1

    Topics: Animals; Calcimycin; Cyclic GMP; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; ortho-Aminobenzoates; Rats; Rats, Wistar; Soluble Guanylyl Cyclase; Structure-Activity Relationship; Sulfonamides

2018