histidine has been researched along with ammonium sulfate in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (68.18) | 18.7374 |
| 1990's | 7 (15.91) | 18.2507 |
| 2000's | 5 (11.36) | 29.6817 |
| 2010's | 2 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deleo, AB; Magasanik, B; Streicher, SL | 1 |
| Holland, R; Pritchard, GG | 1 |
| Kohno, T; Roth, J | 1 |
| Joris, L; Sun, SC; Tsolas, O | 1 |
| Rytka, J | 1 |
| Happe, M; Jockusch, H | 1 |
| Caird, JD; Fackrell, HB; Wiseman, GM | 1 |
| Brown, AJ; Cooper, A; Johnson, CM | 1 |
| Cybulsky, DL; Gornall, AG; Kandel, M; Kandel, SI | 1 |
| Hosoda, S; Nakamura, W; Snell, KC; Stewart, HL | 1 |
| Akutsu, H; Kokubu, T; Ueda, E; Yamamura, Y | 1 |
| Magasanik, B; Prival, MJ | 1 |
| Lee, HJ; Wilson, IB | 1 |
| LaRue, JN; Lee, HJ; Wilson, IB | 2 |
| Oda, KI; Sekiya, T | 1 |
| Bitar, KG; Junk, KW; Vinogradov, N | 1 |
| Angus, CW; Lee, HJ; Wilson, IB | 1 |
| Fenselau, A; Moore, J | 1 |
| Oshima, RG; Price, PA | 1 |
| Das, S; Marshall, FD; Skaper, SD | 1 |
| Koshland, DE; Parsons, SM | 1 |
| Bell, JD; Dastoor, MN; Eisenberg, D; Goodkin, P; Heidner, EG; Weber, BH; Wedler, F | 1 |
| Soffer, RL | 1 |
| Hirs, CH; Kobayashi, Y; Siegelman, HW | 1 |
| Recsei, PA; Snell, EE | 1 |
| Henderson, GB; Snell, EE | 1 |
| Blow, DM; Hess, GP; Wright, CS | 1 |
| Link, RP; Pickrell, JA | 1 |
| Krishna, RV; Krishnaswamy, PR; Rao, DR | 1 |
| Gallwitz, D | 1 |
| Cederbaum, AI; Yang, MX | 1 |
| Ge, SJ; Zhang, LX | 1 |
| Spies, HS; Steenkamp, DJ; Weldrick, D | 1 |
| Bernard, A; Demuyter, P; Erbs, P; Jund, R | 1 |
| Katz, BA | 1 |
| Jones, RA; Lorigan, GA; McNamara, R; Opella, SJ | 1 |
| Jain, R; Narayanan, S; Vangapandu, S | 1 |
| Callender, R; McClendon, S; Zhadin, N | 1 |
| Kois, A; Zakrzewska-Czerwinska, J; Zawilak-Pawlik, AM | 1 |
| Janiczek, O; Mandl, M; Zemanova, J | 1 |
| Prazeres, DM; Queiroz, JA; Sousa, A; Sousa, F | 1 |
| Baysal, Z; Yavuz, M | 1 |
| Bao, YY; Gao, CY; Li, CL; Li, L; Xiao, CB; Zhang, H | 1 |
44 other study(ies) available for histidine and ammonium sulfate
| Article | Year |
|---|---|
Regulation of enzyme formation in Klebsiella aerogenes by episomal glutamine synthetase of Escherichia coli.
Topics: Ammonia-Lyases; Ammonium Sulfate; Cell-Free System; Enterobacter; Enterobacteriaceae; Escherichia coli; Extrachromosomal Inheritance; Genes; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamine; Histidine; Histidine Ammonia-Lyase; Mutation; Plasmids | 1976 |
Regulation of the L-lactase dehydrogenase from Lactobacillus casei by fructose-1,6-diphosphate and metal ions.
Topics: Acetates; Ammonium Sulfate; Buffers; Cell-Free System; Chemical Precipitation; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Citrates; Fructosephosphates; Histidine; Hydrogen-Ion Concentration; Imidazoles; L-Lactate Dehydrogenase; Lacticaseibacillus casei; Maleates; Manganese; Metals; Phosphates; Stereoisomerism; Streptomycin | 1975 |
Electrolyte effects on the activity of mutant enzymes in vivo and in vitro.
Topics: Alcohol Oxidoreductases; Ammonium Sulfate; Crosses, Genetic; Histidine; Histidinol; Kinetics; Mutation; Salmonella Phages; Salmonella typhimurium; Sodium Chloride; Species Specificity; Transduction, Genetic | 1979 |
Purification of crystallization of transaldolase isozyme I and evidence for different genetic origin of isozymes I and III in Candida utilis.
Topics: Amino Acid Sequence; Amino Acids; Ammonium Sulfate; Candida; Chemical Phenomena; Chemical Precipitation; Chemistry, Physical; Chromatography; Crystallization; Cysteine; Genetics, Microbial; Histidine; Isoenzymes; Leucine; Threonine; Transaldolase; Transferases | 1977 |
Positive selection of general amino acid permease mutants in Saccharomyces cerevisiae.
Topics: Amino Acids; Ammonium Sulfate; Biological Transport, Active; Carbon Radioisotopes; Diploidy; Genetic Complementation Test; Histidine; Membrane Transport Proteins; Mutation; Proline; Saccharomyces cerevisiae; Serine; Stereoisomerism; Tyrosine | 1975 |
Phage Qbeta replicase: cell-free synthesis of the phage-specific subunit and its assembly with host subunits to form active enzyme.
Topics: Ammonium Sulfate; Cell-Free System; Coliphages; Escherichia coli; Guanosine Triphosphate; Histidine; Kinetics; Macromolecular Substances; Mutation; Peptide Elongation Factors; Q beta Replicase; RNA Nucleotidyltransferases; RNA, Viral | 1975 |
Trypsin-mediated activation of the alpha-haemolysin of Staphylococcus aureus.
Topics: Amino Acid Sequence; Ammonium Sulfate; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Hemolysin Proteins; Hemolysis; Histidine; Hydrolysis; Isoleucine; Leucine; Methanol; Staphylococcus; Tosyl Compounds; Trypsin | 1975 |
A comparison of the reactivity and stability of wild type and His388----Gln mutant phosphoglycerate kinase from yeast.
Topics: Amino Acid Sequence; Ammonium Sulfate; Calorimetry; Circular Dichroism; Glutamine; Histidine; Kinetics; Mutagenesis, Site-Directed; Phosphoglycerate Kinase; Protein Conformation; Protein Denaturation; Saccharomyces cerevisiae; Sulfhydryl Compounds; Thermodynamics | 1991 |
Reaction of bromoacetazolamide with crystals of human carbonic anhydrase C.
Topics: Acetazolamide; Alkylation; Amino Acid Sequence; Ammonium Sulfate; Binding Sites; Bromine; Carbon Radioisotopes; Carbonic Anhydrases; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Crystallization; Histidine; Humans; Phenylalanine; Protein Binding; Protein Conformation; Ultrafiltration; Zinc | 1974 |
Histidine decarboxylase in the transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis.
Topics: Ammonium Sulfate; Animals; Carboxy-Lyases; Carcinoid Tumor; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Chemical Precipitation; Dopamine; Histamine; Histidine; Hot Temperature; Hydrogen-Ion Concentration; Liver Neoplasms; Neoplasm Transplantation; Pyridoxal Phosphate; Rodentia; Serotonin; Stomach Neoplasms | 1971 |
Partial purification and properties of angiotensin I converting enzyme from rabbit plasma.
Topics: Amino Acids; Ammonium Sulfate; Angiotensin II; Animals; Biological Assay; Carboxypeptidases; Cellulose; Chromatography; Chromatography, Gel; Edetic Acid; Electrophoresis; Endopeptidases; Female; Histidine; Hydrogen-Ion Concentration; Leucyl Aminopeptidase; Peptide Hydrolases; Rabbits; Rats; Uterus | 1971 |
Resistance to catabolite repression of histidase and proline oxidase during nitrogen-limited growth of Klebsiella aerogenes.
Topics: Ammonium Sulfate; Citrates; Conjugation, Genetic; Culture Media; Cyclic AMP; Cytoplasm; Enzyme Repression; Extrachromosomal Inheritance; Formamides; Galactose; Galactosidases; Genetics, Microbial; Glucose; Glutamates; Glycosides; Histidine; Hydrolases; Kinetics; Klebsiella; Lactose; Lyases; Mutation; Nitrogen; Oxidoreductases; Proline; Salmonella typhimurium; Succinates; Sulfides | 1971 |
On the structure of renin substrate.
Topics: Amino Acids; Ammonium Sulfate; Angiotensin II; Animals; Arginine; Blood Proteins; Chemical Precipitation; Chromatography, Ion Exchange; Dipeptides; Esters; Histidine; Hydrolysis; Leucine; Lysine; Peptides; Renin; Serum Globulins; Swine | 1971 |
Angiotensin-converting enzyme from guinea pig and hog lung.
Topics: Ammonium Sulfate; Angiotensin II; Animals; Carbon Isotopes; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography, Gel; Dipeptidases; Endopeptidases; Guinea Pigs; Histidine; Humans; Kinetics; Leucine; Lung; Mathematics; Molecular Weight; Peptides; Species Specificity; Swine | 1971 |
Dipeptidyl carboxypeptidase from Coryne bacterium equi.
Topics: Ammonium Sulfate; Angiotensin II; Autoanalysis; Carbon Isotopes; Carboxypeptidases; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Corynebacterium; Edetic Acid; Electrophoresis; Electrophoresis, Paper; Histidine; Isoflurophate; Leucine; Molecular Weight; Peptides | 1971 |
The altered patterns of transfer RNA in SV40-infected and transformed cells.
Topics: Acylation; Amino Acids; Amino Acyl-tRNA Synthetases; Ammonium Sulfate; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Cell Line; Cell Transformation, Neoplastic; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; DNA, Viral; Electron Transport; Haplorhini; Histidine; Kidney; Nucleic Acid Hybridization; Ribosomes; RNA, Transfer; Simian virus 40; Tritium | 1972 |
The mammalian type cytochrome c of Ustilago sphaerogena.
Topics: Amino Acids; Ammonium Sulfate; Animals; Basidiomycota; Cattle; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Cytochromes; Electron Transport Complex IV; Electrophoresis, Disc; Histidine; Horses; Isoelectric Focusing; Mathematics; Methionine; Mitochondria, Muscle; Molecular Weight; Myocardium; Oxygen Consumption; Spectrophotometry; Ultracentrifugation | 1972 |
Angiotensin-converting enzyme and a second dipeptidyl carboxypeptidase from hog plasma.
Topics: Ammonium Sulfate; Angiotensin II; Animals; Carboxypeptidases; Chemical Precipitation; Chromatography, Gel; Dipeptides; Endopeptidases; Enzyme Activation; Histidine; Leucine; Peptides; Protease Inhibitors; Sodium Chloride; Structure-Activity Relationship; Swine | 1972 |
Reaction of glyceraldehyde-3-phosphate dehydrogenase with dibromoacetone.
Topics: Acetone; Alkylation; Amino Acids; Ammonium Sulfate; Animals; Benzoates; Binding Sites; Borohydrides; Bromine; Carbon Isotopes; Chemical Phenomena; Chemistry; Cysteine; Disulfides; Formates; Glyceraldehyde-3-Phosphate Dehydrogenases; Histidine; Hydrogen-Ion Concentration; Iodoacetates; Kinetics; Mass Spectrometry; Models, Chemical; Muscles; NAD; Nitro Compounds; Oxidation-Reduction; Rabbits | 1972 |
Alkylation of an essential histidine residue in porcine spleen deoxyribonuclease.
Topics: Amino Acids; Ammonium Sulfate; Animals; Binding Sites; Carbon Radioisotopes; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Deoxyribonucleases; DNA; Drug Stability; Electrophoresis, Polyacrylamide Gel; Histidine; Iodoacetates; Phosphoric Diester Hydrolases; Sodium; Spectrophotometry, Ultraviolet; Spleen; Swine; Thymus Gland | 1973 |
Some properties of a homocarnosine-carnosine synthetase isolated from rat brain.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Aminobutyrates; Ammonium Sulfate; Animals; Brain; Carbon Radioisotopes; Chromatography; Chromatography, Paper; Dialysis; Dipeptides; Diphosphates; Electrophoresis, Paper; Female; Histidine; Hydrogen-Ion Concentration; NAD; Nerve Tissue Proteins; Peptide Synthases; Peptides; Rats | 1973 |
A rapid isolation of phosphoribosyladenosine triphosphate synthetase and comparison to native enzyme.
Topics: Adenosine Triphosphate; Ammonium Sulfate; Animals; Chemical Precipitation; Drug Stability; Electrophoresis, Disc; Histidine; Histidine Ammonia-Lyase; Hydrogen-Ion Concentration; Immunodiffusion; Molecular Weight; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Potassium Chloride; Rabbits; Salmonella typhimurium; Sodium Dodecyl Sulfate; Solubility; Temperature | 1974 |
Molecular symmetry and crystal packing of E. coli glutamine synthetase.
Topics: Adenosine Monophosphate; Ammonium Sulfate; Crystallization; Escherichia coli; Glutamate-Ammonia Ligase; Glutathione; Histidine; Macromolecular Substances; Manganese; Microscopy, Electron; Models, Structural; X-Ray Diffraction | 1972 |
Peptide acceptors in the leucine, phenylalanine transfer reaction.
Topics: Acyltransferases; Amino Acyl-tRNA Synthetases; Ammonium Sulfate; Arginine; Carbon Radioisotopes; Caseins; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Dipeptides; Escherichia coli; Histidine; Kinetics; Leucine; Lysine; Phenylalanine; RNA, Transfer; Structure-Activity Relationship | 1973 |
C-phycocyanin from Phormidium luridum. Isolation of subunits.
Topics: Amino Acids; Ammonium Sulfate; Bile Pigments; Calcium Phosphates; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cyanobacteria; Electrophoresis, Disc; Histidine; Imines; Macromolecular Substances; Mercaptoethanol; Molecular Weight; Oxidation-Reduction; Peptides; Plant Proteins; Sodium Dodecyl Sulfate; Spectrophotometry; Trypsin | 1972 |
Prohistidine decarboxylase from Lactobacillus 30a. A new type of zymogen.
Topics: Amino Acids; Ammonium Sulfate; Animals; Carboxy-Lyases; Chromatography, Gel; Cross Reactions; Electrophoresis, Disc; Enzyme Activation; Enzyme Precursors; Histidine; Hydrogen-Ion Concentration; Immunodiffusion; Kinetics; Lactobacillus; Macromolecular Substances; Molecular Weight; Mutation; Pyruvates; Rabbits; Temperature; Time Factors; Ultracentrifugation | 1973 |
Crystalline L-histidinol phosphate aminotransferase from Salmonella typhimurium. Purification and subunit structure.
Topics: Amino Acids; Amino Alcohols; Ammonium Sulfate; Animals; Antibodies, Bacterial; Bacterial Proteins; Binding Sites; Chromatography, DEAE-Cellulose; Chromatography, Gel; Crystallization; Electrophoresis, Disc; Histidine; Hydrogen-Ion Concentration; Immunodiffusion; Male; Molecular Weight; Phenazines; Phosphoric Acids; Pyridoxal Phosphate; Rabbits; Salmonella typhimurium; Tetrazolium Salts; Transaminases | 1973 |
Structure of crystalline methyl-chymotrypsin.
Topics: Acetates; Ammonium Sulfate; Binding Sites; Carbon Isotopes; Chromatography, Ion Exchange; Chymotrypsin; Crystallization; Histidine; Indoles; Mathematics; Methylation; Models, Structural; Nitrobenzenes; Nitrophenols; Protein Binding; Protein Conformation; Serine; Sulfonic Acids; Tosyl Compounds; Tryptophan; Ultrafiltration; X-Ray Diffraction | 1972 |
Isolation and partial characterization of histidine decarboxylase and edema disease-inducing toxin of Escherichia coli strain O139K82H1.
Topics: Aluminum; Ammonium Sulfate; Animals; Carboxy-Lyases; Chick Embryo; Chromatography, Gel; Chromatography, Thin Layer; Culture Techniques; Edema Disease of Swine; Electrophoresis, Disc; Escherichia coli; Histidine; Oxides; Swine; Toxins, Biological; Trypsin | 1971 |
Enzymic synthesis of N-acetyl-L-phenylalanine in Escherichia coli K12.
Topics: Acetates; Acyltransferases; Alanine; Ammonium Sulfate; Calcium Phosphates; Carbon Isotopes; Cell-Free System; Chromatography, Gel; Coenzyme A; Escherichia coli; Histidine; Hydrogen-Ion Concentration; Phenylalanine; Sulfhydryl Reagents; Ultracentrifugation | 1971 |
Histone methylation. Partial purification of two histone-specific methyltransferases from rat thymus nuclei preferentially methylating histones F2a 1 and F3.
Topics: Acetone; Albumins; Amino Acids; Ammonium Sulfate; Animals; Arginine; Cell Nucleus; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytochromes; Electrophoresis; Hemoglobins; Histidine; Histones; Hydrogen-Ion Concentration; Kinetics; Lysine; Male; Methylation; Methyltransferases; Molecular Weight; Muramidase; Peptides; Protamines; Rats; Rats, Inbred Strains; Ribonucleases; S-Adenosylmethionine; Thymus Gland; Tritium | 1971 |
Interaction of ferric complexes with NADH-cytochrome b5 reductase and cytochrome b5: lipid peroxidation, H2O2 generation, and ferric reduction.
Topics: Adenosine Triphosphate; Ammonium Sulfate; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Edetic Acid; Ferric Compounds; Histidine; Hydrogen Peroxide; Iron Chelating Agents; Kinetics; Lipid Peroxidation; Oxidation-Reduction | 1996 |
The immobilized porcine pancreatic exopeptidases and its application in casein hydrolysates debittering.
Topics: Ammonium Sulfate; Animals; Arginine; Caseins; Chitin; Chromatography, High Pressure Liquid; Chymotrypsin; Decapoda; Enzymes, Immobilized; Exopeptidases; Glutamine; Glutaral; Histidine; Humans; Hydrolysis; Leucine; Lysine; Pancreas; Peptide Hydrolases; Phenylalanine; Swine; Taste; Trypsin; Tyrosine | 1996 |
Studies on the biosynthesis of ovothiol A. Identification of 4-mercaptohistidine as an intermediate.
Topics: Alkynes; Amino Acids, Sulfur; Ammonium Sulfate; Animals; Crithidia fasciculata; Cysteine; Glutamates; Glycine; Histidine; Magnetic Resonance Spectroscopy; Methylhistidines; Methyltransferases; Pargyline; Sulfhydryl Compounds; Sulfur | 1996 |
In vivo mutational analysis of highly conserved amino acid residues of the small subunit Cpa1p of the carbamylphosphate synthetase of Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Ammonia; Ammonium Sulfate; Arginine; Aspartic Acid; Carbon-Nitrogen Ligases; Chromosome Mapping; Cysteine; Gene Expression; Glutaminase; Glutamine; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Proline; Saccharomyces cerevisiae; Sequence Analysis; Sequence Deletion; Transformation, Genetic | 1997 |
Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH.
Topics: Alkynes; Ammonium Sulfate; Apoproteins; Aspartic Acid; Biotin; Crystallography, X-Ray; Dimerization; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Imidazoles; Ligands; Models, Molecular; Osmolar Concentration; Protein Conformation; Sodium Chloride; Solubility; Streptavidin | 1997 |
Magnitudes and orientations of the 15N chemical shift tensor of [1-15N]-2'-deoxyguanosine determined on a polycrystalline sample by two-dimensional solid-state NMR spectroscopy.
Topics: Ammonium Sulfate; Computer Simulation; Crystallization; Deoxyguanosine; Histidine; Hydrogen; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Chemical; Nitrogen; Nitrogen Isotopes; Tryptophan | 1999 |
Regiospecific synthesis of 2,3-disubstituted-L-histidines and histamines.
Topics: Alkylation; Ammonium Sulfate; Catalysis; Decarboxylation; Free Radicals; Histamine; Histidine; Silver | 2001 |
The approach to the Michaelis complex in lactate dehydrogenase: the substrate binding pathway.
Topics: Ammonium Sulfate; Animals; Binding Sites; Catalysis; Entropy; Histidine; Hydrogen Bonding; Kinetics; L-Lactate Dehydrogenase; Lasers; Macromolecular Substances; Models, Chemical; Models, Statistical; Mutation; Myocardium; NAD; Organic Chemicals; Protein Binding; Protein Conformation; Signal Transduction; Spectrophotometry; Static Electricity; Substrate Specificity; Swine; Temperature; Thermodynamics; Time Factors | 2005 |
A simplified method for purification of recombinant soluble DnaA proteins.
Topics: Ammonium Sulfate; Bacterial Proteins; Buffers; Chromatography, Affinity; DNA-Binding Proteins; Escherichia coli; Helicobacter pylori; Histidine; Recombinant Proteins; Solubility; Streptomyces coelicolor | 2006 |
Purification and some properties of thiosulfate dehydrogenase from Acidithiobacillus ferrooxidans.
Topics: Acidithiobacillus; Ammonium Sulfate; Chromatography, Gel; Chromatography, Ion Exchange; Diethyl Pyrocarbonate; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Histidine; Hydrogen-Ion Concentration; Isoelectric Point; Molecular Weight; Oxidoreductases; Sodium Dodecyl Sulfate; Substrate Specificity; Time Factors | 2007 |
Histidine affinity chromatography of homo-oligonucleotides. Role of multiple interactions on retention.
Topics: Ammonium Sulfate; Chromatography, Affinity; Histidine; Hydrogen-Ion Concentration; Nucleic Acid Conformation; Poly T; Polyribonucleotides; Temperature | 2009 |
Preparation and use of poly(hydroxyethyl methacrylate) cryogels containing L-histidine for β-casein adsorption.
Topics: Adsorption; Ammonium Sulfate; Caseins; Cryogels; Histidine; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Osmolar Concentration; Polyhydroxyethyl Methacrylate; Polymerization; Putrescine; Temperature | 2013 |
Preparation of polyclonal antibody against porcine beta defensin 2 and identification of its distribution in tissues of pig.
Topics: Ammonium Sulfate; Animals; Antibodies; Antibody Specificity; beta-Defensins; Blotting, Western; Chromatography, Ion Exchange; Enzyme-Linked Immunosorbent Assay; Gene Expression; Histidine; Immune Sera; Immunity, Innate; Immunohistochemistry; Intestines; Kidney; Liver; Oligopeptides; Rabbits; Recombinant Fusion Proteins; Swine; Tongue | 2015 |