hispidulin and baicalein

hispidulin has been researched along with baicalein* in 1 studies

Other Studies

1 other study(ies) available for hispidulin and baicalein

Article	Year
Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase. FEBS letters, 2016, Volume: 590, Issue:16 Oroxylin A and hispidulin, compounds which are abundant in both Scutellaria and liverwort species, are important lead compounds for the treatment of ischemic cerebrovascular disease. Their enzymatic synthesis requires an O-methyltransferase able to interact with the related flavonoid's 6-OH group, but such an enzyme has yet to be identified in plants. Here, the gene encoding an O-methyltransferase (designated PaF6OMT) was isolated from the liverwort species Plagiochasma appendiculatum. A test of alternative substrates revealed that its strongest preferences were baicalein and scutellarein, which were converted into, respectively, oroxylin A and hispidulin. Allowed a sufficient reaction time, the conversion rate of these two substrates was, respectively, 90% and 100%. PaF6OMT offers an enzymatic route to the synthesis of oroxylin A and hispidulin. Topics: Apigenin; Cerebrovascular Disorders; Cloning, Molecular; Flavanones; Flavones; Flavonoids; Hepatophyta; Humans; Methyltransferases; Substrate Specificity	2016

Article

Year

Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6-O-methyltransferase.

FEBS letters, 2016, Volume: 590, Issue:16

Oroxylin A and hispidulin, compounds which are abundant in both Scutellaria and liverwort species, are important lead compounds for the treatment of ischemic cerebrovascular disease. Their enzymatic synthesis requires an O-methyltransferase able to interact with the related flavonoid's 6-OH group, but such an enzyme has yet to be identified in plants. Here, the gene encoding an O-methyltransferase (designated PaF6OMT) was isolated from the liverwort species Plagiochasma appendiculatum. A test of alternative substrates revealed that its strongest preferences were baicalein and scutellarein, which were converted into, respectively, oroxylin A and hispidulin. Allowed a sufficient reaction time, the conversion rate of these two substrates was, respectively, 90% and 100%. PaF6OMT offers an enzymatic route to the synthesis of oroxylin A and hispidulin.

Topics: Apigenin; Cerebrovascular Disorders; Cloning, Molecular; Flavanones; Flavones; Flavonoids; Hepatophyta; Humans; Methyltransferases; Substrate Specificity

2016