hispidin has been researched along with terphenyllin* in 1 studies
1 other study(ies) available for hispidin and terphenyllin
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Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites.
HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug strategies for anti-retroviral therapy, with potentially significant advantages over existing therapies. In this report, a series of HIV-1 inhibitors isolated from the organic extract of fermentations from terrestrial fungi is described. These fungal species, belonging to a variety of genera, were collected from throughout the world following the strict guidelines of Rio Convention on Biodiversity. The polyketide- and terpenoid-derived inhibitors are represented by two naphthoquinones, a biphenyl and two triphenyls, a benzophenone, four aromatics with or without catechol units, a linear aliphatic terpenoid, a diterpenoid, and a sesterterpenoid. These compounds inhibited the coupled and strand-transfer reaction of HIV-1 integrase with an IC(50) value of 0.5-120 micro M. The bioassay-directed isolation, structure elucidation, and HIV-1 inhibitory activity of these compounds are described. Topics: Alkenes; Anthraquinones; Aspergillus; Biphenyl Compounds; Caffeic Acids; Enzyme Inhibitors; Esters; Fatty Acids; Fermentation; Fungal Proteins; HIV Integrase; Industrial Microbiology; Monosaccharides; Penicillium; Pyrones; Sesterterpenes; Talaromyces; Terpenes; Terphenyl Compounds | 2003 |