hirsutine--(16e-20beta)-isomer has been researched along with mitragynine* in 4 studies
4 other study(ies) available for hirsutine--(16e-20beta)-isomer and mitragynine
| Article | Year |
|---|---|
Activity of
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in vivo activity of kratom alkaloids at serotonin receptors (5-HTRs). Paynantheine and speciogynine exhibited high affinity for 5-HT Topics: Analgesics; Animals; Behavior, Animal; Female; HEK293 Cells; Humans; Male; Nociceptive Pain; Rats, Sprague-Dawley; Receptors, Serotonin; Secologanin Tryptamine Alkaloids | 2021 |
Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats.
Kratom, Topics: Alkaloids; Animals; Indole Alkaloids; Indoles; Male; Mitragyna; Molecular Structure; Oxindoles; Plant Preparations; Rats; Rats, Sprague-Dawley; Secologanin Tryptamine Alkaloids; Spiro Compounds | 2021 |
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2020 |
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
Mitragynine (1) is a major alkaloidal component in the Thai traditional medicinal herb, Mitragyna speciosa, and has been proven to exhibit analgesic activity mediated by opioid receptors. By utilizing this natural product as a lead compound, synthesis of some derivatives, evaluations of the structure-activity relationship, and surveys of the intrinsic activities and potencies on opioid receptors were performed with guinea pig ileum. The affinities of some compounds for mu-, delta-, and kappa-receptors were determined in a receptor binding assay. The essential structural moieties in the Corynanthe type indole alkaloids for inducing the opioid agonistic activity were also clarified. The oxidative derivatives of mitragynine, i.e., mitragynine pseudoindoxyl (2) and 7-hydroxymitragynine (12), were found as opioid agonists with higher potency than morphine in the experiment with guinea pig ileum. In addition, 2 induced an analgesic activity in the tail flick test in mice. Topics: Analgesics; Animals; Brain; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indole Alkaloids; Ligands; Mice; Models, Molecular; Morphine; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Structure-Activity Relationship | 2002 |