Compounds > higenamine
Page last updated: 2024-09-02

higenamine and propranolol

higenamine has been researched along with propranolol in 4 studies

Compound Research Comparison

Studies
(higenamine)		Trials
(higenamine)		Recent Studies (post-2010)
(higenamine)		Studies
(propranolol)		Trials
(propranolol)		Recent Studies (post-2010) (propranolol)
13647033,3103,4063,218

Protein Interaction Comparison

ProteinTaxonomyhigenamine (IC50)propranolol (IC50)
Beta-1 adrenergic receptor Cavia porcellus (domestic guinea pig)0.0347
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)2.294
Cytochrome P450 1A2Homo sapiens (human)4
Beta-2 adrenergic receptorHomo sapiens (human)0.0114
Beta-1 adrenergic receptorHomo sapiens (human)0.0575
5-hydroxytryptamine receptor 1AHomo sapiens (human)3.9811
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.012
Cytochrome P450 2D6Homo sapiens (human)2.9706
Beta-3 adrenergic receptorHomo sapiens (human)0.0493
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0288
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)0.012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0827
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0288
Beta-3 adrenergic receptorRattus norvegicus (Norway rat)0.012
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.466
5-hydroxytryptamine receptor 2CHomo sapiens (human)2.294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0288
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.243
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0288
Sodium-dependent serotonin transporterHomo sapiens (human)0.38
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.342
5-hydroxytryptamine receptor 6Homo sapiens (human)3.065
Beta-2 adrenergic receptorCanis lupus familiaris (dog)0.017
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0288
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0288
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.828
Sodium channel protein type 5 subunit alphaHomo sapiens (human)2.1
Sodium/bile acid cotransporterHomo sapiens (human)5.5
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0288
GABA theta subunitRattus norvegicus (Norway rat)0.0288
Sigma non-opioid intracellular receptor 1Homo sapiens (human)2.87
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0288

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, KC; Lim, JK; Park, CW1
Chen, CM; Lo, CF; Wong, KK1
Abe, K; Akaishi, T; Morioka, T; Okumura, H; Ueki, T1
Inagaki, Y; Kato, E; Kawabata, J1

Other Studies

4 other study(ies) available for higenamine and propranolol

ArticleYear
Effects of higenamine on isolated heart adrenoceptor of rabbit.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 267, Issue:2

    Topics: Alkaloids; Animals; Drug Interactions; Electric Stimulation; Epinephrine; Female; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Propranolol; Rabbits; Receptors, Adrenergic; Tetrahydroisoquinolines

1984
Endothelium-dependent higenamine-induced aortic relaxation in isolated rat aorta.
    Planta medica, 1997, Volume: 63, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alkaloids; Animals; Aorta; Endothelium, Vascular; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Relaxation; Propranolol; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines

1997
Biphasic tracheal relaxation induced by higenamine and nantenine from Nandina domestica Thunberg.
    Journal of pharmacological sciences, 2011, Volume: 115, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alkaloids; Animals; Aporphines; Calcium; Fruit; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Nandiniidae; Potassium; Propranolol; Tetrahydroisoquinolines; Trachea

2011
Higenamine 4'-O-β-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through β2-adrenergic receptor.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Adrenergic Antagonists; Adrenergic beta-Agonists; Alkaloids; AMP-Activated Protein Kinases; Animals; Cell Line; Chromones; Gene Expression Regulation; Glucose; Glucosides; Hypoglycemic Agents; Mice; Morpholines; Muscle Fibers, Skeletal; Nelumbo; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plant Extracts; Propranolol; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptors, Adrenergic, beta-2; Seeds; Signal Transduction; Tetrahydroisoquinolines

2015