Compounds > higenamine
Page last updated: 2024-09-02

higenamine and papaverine

higenamine has been researched along with papaverine in 2 studies

Compound Research Comparison

Studies
(higenamine)		Trials
(higenamine)		Recent Studies (post-2010)
(higenamine)		Studies
(papaverine)		Trials
(papaverine)		Recent Studies (post-2010) (papaverine)
1364706,027305355

Protein Interaction Comparison

ProteinTaxonomyhigenamine (IC50)papaverine (IC50)
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ARattus norvegicus (Norway rat)0.076
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.3
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)8.8
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)1.7
Bile salt export pumpHomo sapiens (human)10
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)1.6
Cytochrome P450 2C19Homo sapiens (human)0.762
Serine hydroxymethyltransferase, mitochondrialHomo sapiens (human)2.6915
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)9
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)1.4
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)7.2444
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)1.03
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)9
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)0.697
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Rattus norvegicus (Norway rat)0.036
Phosphodiesterase Sus scrofa (pig)0.62
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.07

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, KC; Lim, JK; Park, CW1
Chang, KC; Chong, WS; Lee, IJ1

Other Studies

2 other study(ies) available for higenamine and papaverine

ArticleYear
Pharmacological evaluation of GS-389, a novel tetrahydroisoquinoline analog related to higenamine, on vascular smooth muscle.
    Life sciences, 1992, Volume: 51, Issue:1

    Topics: Alkaloids; Animals; Aorta, Thoracic; Bicarbonates; Cardiotonic Agents; Drug Interactions; Egtazic Acid; Endothelium, Vascular; Female; In Vitro Techniques; Isoquinolines; Male; Methylene Blue; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Papaverine; Phenylephrine; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines; Vasodilator Agents

1992
Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:4

    Topics: Adrenergic beta-Agonists; Alkaloids; Animals; Aorta, Thoracic; Calcium Channels; Cyclic AMP; Electric Stimulation; Female; Heart; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Papaverine; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines

1994