Compounds > higenamine
Page last updated: 2024-09-02

higenamine and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

higenamine has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 3 studies

Compound Research Comparison

Studies
(higenamine)		Trials
(higenamine)		Recent Studies (post-2010)
(higenamine)		Studies
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)		Trials
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)		Recent Studies (post-2010) (2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
1364704,82351,810

Protein Interaction Comparison

ProteinTaxonomyhigenamine (IC50)2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (IC50)
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Methyltransferase WbddEscherichia coli68
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)1.6413
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)1.4218
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.002
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)9.614
Cytochrome P450 1A2Homo sapiens (human)1
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)1.6
Serine/threonine-protein kinase pim-1Homo sapiens (human)3.364
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)1.6
Casein kinase II subunit alpha'Homo sapiens (human)6.9
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)3.1638
5-hydroxytryptamine receptor 2AHomo sapiens (human)2.796
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.002
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)2.3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformBos taurus (cattle)3.7533
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)1.4593
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (house mouse)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)1.2922
Serine/threonine-protein kinase mTORHomo sapiens (human)4.1638
Serine/threonine-protein kinase mTORRattus norvegicus (Norway rat)2.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)2.4845
Glycogen synthase kinase-3 betaHomo sapiens (human)8.1
Serine/threonine-protein kinase PLK1Homo sapiens (human)2.05
Casein kinase II subunit betaHomo sapiens (human)6.9
Casein kinase II subunit alphaHomo sapiens (human)6.9
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)1.32
Mu-type opioid receptorCavia porcellus (domestic guinea pig)1.6
Serine/threonine-protein kinase pim-3Homo sapiens (human)1.4
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)1.72
Serine/threonine-protein kinase PLK3Homo sapiens (human)3

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, KC; Ha, YM; Kim, HJ; Kim, MY; Kim, YM; Lee, JH; Lee, YS; Park, MK1
Inagaki, Y; Kato, E; Kawabata, J1
Guo, S; Su, J; Wu, C; Xing, H; Zhang, J; Zhang, Y; Zhao, W1

Other Studies

3 other study(ies) available for higenamine and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

ArticleYear
Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways.
    Apoptosis : an international journal on programmed cell death, 2012, Volume: 17, Issue:5

    Topics: Alkaloids; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Hypoxia; Cell Survival; Cells, Cultured; Chromones; Enzyme Induction; Heme Oxygenase (Decyclizing); HMGB1 Protein; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Morpholines; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Tetrahydroisoquinolines

2012
Higenamine 4'-O-β-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through β2-adrenergic receptor.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Adrenergic Antagonists; Adrenergic beta-Agonists; Alkaloids; AMP-Activated Protein Kinases; Animals; Cell Line; Chromones; Gene Expression Regulation; Glucose; Glucosides; Hypoglycemic Agents; Mice; Morpholines; Muscle Fibers, Skeletal; Nelumbo; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plant Extracts; Propranolol; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptors, Adrenergic, beta-2; Seeds; Signal Transduction; Tetrahydroisoquinolines

2015
Higenamine protects neuronal cells from oxygen-glucose deprivation/reoxygenation-induced injury.
    Journal of cellular biochemistry, 2019, Volume: 120, Issue:3

    Topics: Alkaloids; Animals; Animals, Newborn; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Chromones; Gene Expression Regulation; Glucose; Heme Oxygenase-1; Hippocampus; Male; Malondialdehyde; Models, Biological; Morpholines; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxygen; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Tetrahydroisoquinolines

2019