hexobarbital has been researched along with theophylline in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Caron, G; Ermondi, G | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Weiner, M | 1 |
| Breimer, DD; Janssens, AR; Schellens, JH; van der Velde, EA; van der Wart, JH | 1 |
| Breimer, DD; Danhof, M; Schellens, JH; van der Velde, EA; van der Wart, JH | 1 |
| Nickel, B; Niebch, G; Peter, G; Tibes, U; von Schlichtegroll, A | 1 |
| Blake, DA; Buterbaugh, GG; Weiner, M | 2 |
| Brenner, G; Trautmann, H | 1 |
| Goodsell, EB; Stein, HH; Wenzke, KJ | 1 |
| Burgison, RM; Dietz, AJ | 1 |
| Scheler, W; Stremmel, D | 1 |
| Blouin, RA; Hill, DB; Israel, BC; McClain, CJ; Shedlofsky, SI | 1 |
| Breimer, DD; Groen, K | 1 |
| Blouin, RA; Israel, BC; McIntyre, W; Shedlofsky, SI | 1 |
| Blouin, RA; Israel, BC; Shedlofsky, SI; Tosheva, R | 1 |
2 trial(s) available for hexobarbital and theophylline
| Article | Year |
|---|---|
Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients.
Topics: Aged; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Hexobarbital; Humans; Interferon-alpha; Liver; Male; Middle Aged; Neoplasms; Theophylline | 1993 |
Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; C-Reactive Protein; Cytochrome P-450 Enzyme System; Female; Fever; Hexobarbital; Humans; Hypnotics and Sedatives; Interleukin-6; Lipopolysaccharides; Liver; Middle Aged; Nephelometry and Turbidimetry; Phosphodiesterase Inhibitors; Regression Analysis; Theophylline; Tumor Necrosis Factor-alpha | 1997 |
18 other study(ies) available for hexobarbital and theophylline
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Comparative effects of adenosine and adenine and guanine nucleotides on drug biotransformation in rats.
Topics: Adenine; Adenosine; Aniline Compounds; Animals; Biotransformation; Bucladesine; Cyclic AMP; Guanine Nucleotides; Hexobarbital; In Vitro Techniques; Liver; Male; Microsomes, Liver; Pharmaceutical Preparations; Rats; Sleep; Theophylline | 1975 |
Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a 'cocktail' approach.
Topics: Adult; Aged; Antipyrine; Female; Hexobarbital; Humans; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Theophylline | 1989 |
Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach.
Topics: Adult; Antipyrine; Contraceptives, Oral; Female; Hexobarbital; Humans; Male; Metabolic Clearance Rate; Oxidation-Reduction; Regression Analysis; Sex Factors; Smoking; Theophylline | 1988 |
Fenetylline: new results on pharmacology, metabolism and kinetics.
Topics: Amphetamines; Animals; Appetite Depressants; Drug Interactions; Ethanol; Hexobarbital; Humans; In Vitro Techniques; Liver; Mazindol; Motor Activity; Rats; Theophylline | 1986 |
Studies on the mechanism of inhibition of drug biotransformation by cyclic adenine nucleotides.
Topics: Aniline Compounds; Animals; Biotransformation; Bucladesine; Cyclic AMP; Cytochrome P-450 Enzyme System; Depression, Chemical; Glucagon; Glucosephosphate Dehydrogenase; Glucosephosphates; Hexobarbital; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Rats; Theophylline; Time Factors | 1972 |
[Effect of xanthinol-nicotinate on detoxification processes in liver. Experimental studies on the model of hexobarbital-narcosis in rat].
Topics: Anesthesia, General; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Depression, Chemical; Female; Hexobarbital; Liver; Male; Niacinamide; Nicotinic Acids; Pyridines; Rats; Sex Factors; Sleep; Theophylline; Time Factors | 1969 |
8-substituted theophyllines. In vitro inhibition of 3',5'-cyclic adenosine monophosphate phosphodiesterase and pharmacological spectrum in mice.
Topics: Animals; Antidepressive Agents; Blood Glucose; Brain; Central Nervous System; Cyclic AMP; Dihydroxyphenylalanine; Diuresis; Drug Interactions; Drug Synergism; Hexobarbital; Injections, Intraperitoneal; Lethal Dose 50; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Phosphoric Monoester Hydrolases; Structure-Activity Relationship; Theophylline; Time Factors | 1971 |
Inhibition of hepatic drug metabolism by cyclic 3',5'-adenosine monophosphate.
Topics: Aniline Compounds; Animals; Bucladesine; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Hexobarbital; In Vitro Techniques; Insulin; Liver; Male; Perfusion; Rats; Sleep; Starvation; Theophylline; Time Factors | 1972 |
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental | 1968 |
[On the pharmacologic effects of several new theophylline derivaives].
Topics: Analgesics; Animals; Cardiovascular System; Cattle; Chemical Phenomena; Chemistry; Diuresis; Electrolytes; Guinea Pigs; Hemolysis; Hexobarbital; Mice; Rats; Sleep; Theophylline | 1968 |
Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
Topics: Administration, Oral; Adult; Antipyrine; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Endotoxins; Hexobarbital; Humans; Interleukin-6; Lipopolysaccharides; Liver; Male; Metabolic Clearance Rate; Orosomucoid; Pharmacokinetics; Theophylline; Tumor Necrosis Factor-alpha | 1994 |
Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Half-Life; Hexobarbital; Humans; Molecular Probes; Rats; Substrate Specificity; Theophylline | 1996 |