hexobarbital and propranolol

hexobarbital has been researched along with propranolol in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199022 (68.75)18.7374
1990's4 (12.50)18.2507
2000's5 (15.63)29.6817
2010's1 (3.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Caron, G; Ermondi, G1
Abraham, MH; Acree, WE; Ibrahim, A1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Gomba, S; Kulcsár, A; Kulscár-Gergely, J1
Branch, RA; Rogers, L; Shand, DG; Villeneuve, JP; Wood, AJ1
Ankermann, H; Klinger, W; Müller, D1
Grundin, R1
Arushanian, EB; Botvev Orkhiĭ, P1
Kulcsár-Gergely, J1
Tokola, O1
Erina, EV; Shkhvatsabaia, IK1
Almirante, L; Murmann, W; Saccani-Guelfi, M1
Ammon, HP; Estler, CJ1
Hermansen, K1
Kierfeld, E; Wagner, J1
Topham, JC1
Omiya, Y1
Donhoffer, S; Kellermayer, M; Székely, M1
Konga, K; Mizuguchi, T; Nakai, K; Omiya, Y1
Grunden, LR1
Ankermann, H; Grübner, I; Klinger, W1
Jacob, R; Kissling, G; Segarra-Domenech, J1
van Zwieten, PA1
Abbas-Ali, B; Bergs, C; Heinemeyer, G; Hildebrandt, AG; Roots, I; Schlede, E; Schmoldt, A1
Belpaire, FM; De Rick, A; Rosseel, MT1
Kastelova, A; Stoytchev, T1
Manavalan, JS; Quartermain, D; Stone, EA1
Kastelova, A; Koleva, M; Staneva-Stoytcheva, D; Stoytchev, T1
Bast, A; Noordhoek, J1

Reviews

1 review(s) available for hexobarbital and propranolol

ArticleYear
[Problems in drug therapy of hypertension].
    Terapevticheskii arkhiv, 1974, Volume: 46, Issue:9

    Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Benzimidazoles; Benzothiadiazines; Cardiac Glycosides; Catecholamines; Diuretics; Drug Therapy, Combination; Guanethidine; Hemodynamics; Hexobarbital; Humans; Hypertension; Methyldopa; Middle Aged; Parasympatholytics; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors; Water-Electrolyte Balance

1974

Other Studies

31 other study(ies) available for hexobarbital and propranolol

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Estrogens as disposing factors in experimental liver injury.
    Experimentelle Pathologie, 1978, Volume: 16, Issue:1-6

    Topics: Animals; Biotransformation; Carbon Tetrachloride Poisoning; Drug Interactions; Estrogens; Female; Hexobarbital; Liver; Necrosis; Propranolol; Rats

1978
Impaired drug metabolism in experimental cirrhosis in the rat.
    Biochemical pharmacology, 1978, Volume: 27, Issue:22

    Topics: Aminopyrine; Animals; Half-Life; Hexobarbital; Kinetics; Liver; Liver Cirrhosis, Experimental; Male; Pharmaceutical Preparations; Propranolol; Rats

1978
[The effect of symphathicotropic substances on liver microsomes in vivo and in vitro].
    Acta biologica et medica Germanica, 1975, Volume: 34, Issue:4

    Topics: Aminopyrine; Animals; Dihydroergotamine; Ephedrine; Hexobarbital; In Vitro Techniques; Male; Microsomes, Liver; p-Dimethylaminoazobenzene; Propranolol; Rats; Sympatholytics; Sympathomimetics

1975
Metabolic interaction of ethanol and alprenolol in isolated liver cells.
    Acta pharmacologica et toxicologica, 1975, Volume: 37, Issue:3

    Topics: Alprenolol; Animals; Ethanol; Hexobarbital; Liver; Male; Microsomes, Liver; Propranolol; Pyrazoles; Rats

1975
[The influence of propranolol on the circadian fluctuations in the duration of the hypnogenic effect of diazepam and hexenal].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 114, Issue:8

    Topics: Animals; Circadian Rhythm; Diazepam; Drug Interactions; Hexobarbital; Male; Mice; Propranolol; Reaction Time; Sleep; Time Factors

1992
Action of beta-adrenoceptor blockers on liver function of rats.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:7

    Topics: Adrenergic beta-Antagonists; Animals; Blood Glucose; Carbohydrate Metabolism; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Liver; Liver Function Tests; Liver Glycogen; Male; Microsomes, Liver; Propanolamines; Propranolol; Rats; Rats, Inbred Strains; Sleep; Time Factors

1989
Barbiturate and ethanol sleeping times and pharmacokinetics of propranolol in mice after intravenous administration of haem arginate.
    Pharmacology & toxicology, 1987, Volume: 60, Issue:1

    Topics: Animals; Arginine; Ethanol; Heme; Hexobarbital; Injections, Intravenous; Kinetics; Male; Mice; Propranolol; Sleep; Time Factors

1987
Effects of hexobarbitone, ether, morphine, and urethane upon the acute toxicity of propranolol and D-(--)-INPEA.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:10

    Topics: Amino Alcohols; Animals; Atropine; Bradycardia; Central Nervous System; Drug Synergism; Ethers; Heart Arrest; Heart Rate; Hexobarbital; Lidocaine; Male; Mice; Morphine; Nitrobenzenes; Propranolol; Quinidine; Seizures; Sleep; Urethane

1966
Absence of central nervous system effects of practalol [ICI 50,172; 4-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide], a new adrenergic beta-receptor blocking drug.
    The Journal of pharmacy and pharmacology, 1969, Volume: 21, Issue:8

    Topics: Acetanilides; Anesthetics; Animals; Central Nervous System; Hexobarbital; Male; Mice; Motor Activity; Pentylenetetrazole; Propranolol; Sympatholytics

1969
Effect of different beta-adrenergic receptor blocking agents on hexobarbital induced narcosis in mice.
    Acta pharmacologica et toxicologica, 1969, Volume: 27, Issue:6

    Topics: Adjuvants, Anesthesia; Adrenergic beta-Antagonists; Amino Alcohols; Animals; Anticonvulsants; Drug Synergism; Hexobarbital; Male; Mice; Propranolol; Sleep; Stereoisomerism; Sympatholytics

1969
[Prolonging hexabarbiturate anesthesia by beta adrenolytic drugs].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Drug Synergism; Ethanolamines; Guinea Pigs; Hexobarbital; Male; Mice; Propranolol; Sympatholytics

1971
Relationship between difference spectra and metabolism. Barbiturates, drug interaction and species difference.
    Biochemical pharmacology, 1970, Volume: 19, Issue:5

    Topics: Acetanilides; Acetates; Amino Alcohols; Aminopyrine; Aniline Compounds; Animals; Barbiturates; Binding Sites; Chemical Phenomena; Chemistry; Chlorpromazine; Cytochromes; Drug Antagonism; Drug Synergism; Ethanolamines; Hexobarbital; Macaca; Male; Mice; Microsomes, Liver; Pentobarbital; Phenobarbital; Proadifen; Propranolol; Protein Binding; Rats; Sleep; Species Specificity; Spectrophotometry; Thiazoles; Tremorine

1970
[Potentiation of thiopental anesthesia by adrenaline].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1971, Volume: 67, Issue:3

    Topics: Anesthesia; Animals; Blood Proteins; Brain; Brain Chemistry; Drug Synergism; Epinephrine; Fatty Acids, Nonesterified; Hexobarbital; Injections, Intraperitoneal; Isoproterenol; Lipid Metabolism; Male; Mice; Norepinephrine; Phentolamine; Propranolol; Protein Binding; Rats; Sleep; Sulfur Isotopes; Thiopental

1971
The effect of hypoxia, hypercapnia, -adrenergic blockade and anaesthesia on heat production by periaortic brown adipose tissue.
    Acta physiologica Academiae Scientiarum Hungaricae, 1971, Volume: 40, Issue:3

    Topics: Acclimatization; Adipose Tissue, Brown; Anesthesia; Animals; Aorta, Thoracic; Body Temperature Regulation; Female; Hexobarbital; Hypercapnia; Hypoxia; Male; Propranolol; Rats; Sympatholytics

1971
Potentiation of barbiturate anesthesia by catecholamines.
    Japanese journal of pharmacology, 1967, Volume: 17, Issue:2

    Topics: Anesthesia; Animals; Barbiturates; Catecholamines; Drug Synergism; Epinephrine; Hexobarbital; Injections, Intraperitoneal; Isoproterenol; Norepinephrine; Phentolamine; Propranolol; Rats; Sympatholytics; Thiopental

1967
Action of intracerebroventricular epinephrine on gross behavior, locomotor activity and hexobarbital sleeping times in rats.
    International journal of neuropharmacology, 1969, Volume: 8, Issue:6

    Topics: Acetylcholine; Animals; Catecholamines; Cerebral Ventricles; Creatinine; Dextroamphetamine; Drug Synergism; Ephedrine; Epinephrine; Exploratory Behavior; Hexobarbital; Injections; Isoproterenol; Male; Motor Activity; Norepinephrine; Phenethylamines; Phenoxybenzamine; Phenylephrine; Propranolol; Rats; Sensory Receptor Cells; Sleep; Time Factors

1969
[Various substances and substance classes with inductive properties. I. Aminoketones and aminoalcohols].
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 191, Issue:1

    Topics: Amino Alcohols; Aminopyrine; Animals; Ascorbic Acid; Dealkylation; Hexobarbital; Ketones; Male; Propranolol; Rats; Sleep; Triazoles

1971
[After-contractions as a cause of late diastolic "tonus increase" of the heart. Studies of diastolic extensibility of the isolated frog heart under propranolol, hexobarbital and k-strophanthin].
    Zeitschrift fur Kreislaufforschung, 1969, Volume: 58, Issue:1

    Topics: Animals; Cardiac Output; Cardiac Volume; Heart; Heart Failure; Heart Function Tests; Hexobarbital; Myography; Ouabain; Propranolol

1969
Decrease in ionic permeability of the cell membrane in guinea-pig atrial tissue by treatment with antifibrillatory agents and hexobarbitone, determined by means of 86Rb.
    British journal of pharmacology, 1969, Volume: 35, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Cell Membrane Permeability; Guinea Pigs; Heart; Heart Atria; Heart Rate; Hexobarbital; In Vitro Techniques; Muscle Contraction; Propranolol; Quinidine; Radioisotopes; Rubidium; Tetracaine

1969
Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone.
    Advances in experimental medicine and biology, 1981, Volume: 136 Pt A

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Catalase; Digitoxin; Hexobarbital; Hydrogen Peroxide; Kinetics; Male; Methanol; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Propranolol; Rabbits; Rats; Spironolactone

1981
Enhanced plasma binding of propranolol and oxprenolol and induction of hexobarbital and antipyrine metabolism by rifampicin treatment in the dog.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 259, Issue:2

    Topics: Animals; Antipyrine; Blood Proteins; Dogs; Female; Half-Life; Hexobarbital; Male; Oxprenolol; Propranolol; Protein Binding; Rifampin

1982
Effects of propranolol, pindolol and atenolol after multiple administration in rats on the duration of hexobarbital sleeping time and on the activity of some drug-metabolizing enzyme systems.
    Acta physiologica et pharmacologica Bulgarica, 1993, Volume: 19, Issue:4

    Topics: Animals; Atenolol; Cytochromes; Hexobarbital; Liver; Male; Mixed Function Oxygenases; Pindolol; Propranolol; Rats; Rats, Wistar; Sleep

1993
Delayed arousal from anesthesia: a further similarity between stress and beta-1 adrenoceptor blockade.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:1

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Anesthesia, General; Anesthetics, Inhalation; Animals; Arousal; Betaxolol; Dose-Response Relationship, Drug; Halothane; Hexobarbital; Hypnotics and Sedatives; Male; Mice; Propanolamines; Propranolol; Sleep; Stress, Psychological; Time Factors

1996
Combined effect of propranolol with nifedipine or with diltiazem on rat liver monooxygenase activities.
    Toxicology letters, 1999, Mar-29, Volume: 105, Issue:2

    Topics: Adrenergic beta-Antagonists; Aminopyrine N-Demethylase; Animals; Calcium Channel Blockers; Cytochrome P-450 Enzyme System; Cytochromes b5; Diltiazem; Ethylmorphine-N-Demethylase; Hexobarbital; Hypnotics and Sedatives; Liver; Male; NADPH-Ferrihemoprotein Reductase; Nifedipine; Propranolol; Rats; Rats, Wistar; Sleep

1999
Calculation of competitive inhibition of substrate binding to cytochrome P-450 illustrated by the interaction of d,l-propranolol with d,l-hexobarbital.
    Biochemical pharmacology, 1980, Mar-01, Volume: 29, Issue:5

    Topics: Animals; Binding Sites; Binding, Competitive; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Male; Microsomes, Liver; Propranolol; Protein Binding; Rats; Rats, Wistar; Spectrophotometry; Substrate Specificity

1980