hexobarbital has been researched along with proadifen in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 80 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dvorchik, BH; Hartman, RD; Marietta, MP; Vesell, ES; Weisz, J | 1 |
| Ford, JH; Gopinath, C | 1 |
| Bridges, JW; Elcombe, CR; Illing, HP; King, LJ; Netter, KJ; Nimmo-Smith, RH; Wolf, CR | 1 |
| Suriyachan, D; Thithapandha, A | 1 |
| Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K | 1 |
| Franklin, MR; James, RC | 1 |
| Drew, R; Priestly, BG | 1 |
| Krupa, V; Marks, GS; Taub, H | 1 |
| Aeschbacher, HU; Atkinson, J; Domahidy, B | 1 |
| Jablońska, JK; Piotrowski, JK; Wiśniewska-Knypl, JM | 1 |
| Capdevila, J; Moldéus, P; Orrenius, S; Vadi, H | 1 |
| Doggett, NS | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM | 1 |
| Bousquet, WS; Holcslaw, TL; Miya, TS | 1 |
| Herczeg, T; Mathur, PP; Reavey-Cantwell, NH; Smyth, RD | 1 |
| Lee, IP; Lucier, GW | 1 |
| Crouch, RK; el-Hage, A; Ferrans, VJ; Herman, EH; Yang, GC | 1 |
| Atal, CK; Dubey, RK; Singh, J | 1 |
| Kato, R | 1 |
| Conney, AH; Kuntzman, R; Welch, R | 1 |
| Anders, MW; Gundu Rao, HR | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Absil, J; Buchel, L | 1 |
| Hickie, RA; Kalant, H | 1 |
| Illing, HP; Netter, KJ | 1 |
| Boobis, AR; Powis, G | 1 |
| McPhillips, JJ; Wooles, WR | 1 |
| Kupfer, D; Peets, L | 1 |
| Gigon, PL; Gillette, JR; Gram, TE | 2 |
| Gillette, JR; Sasame, HA | 1 |
| Kupfer, D | 1 |
| Kato, R; Onoda, K; Takayanagi, M | 1 |
| Topham, JC | 1 |
| Carminati, GM; Chiabotto, L; Duzzi, L | 1 |
| Munson, AE; Wooles, WR | 1 |
| Archakov, AI; Kretovich, WL; Melik-Sarkissian, SS; Raikchinstein, MV | 1 |
| Kaltiala, EH; Kärki, NT; Larmi, TK; Pelkonen, O | 1 |
| Doi, T; Kojima, S; Tsujimoto, A | 1 |
| Gilleran, TG; Lukas, G; Zak, SB | 1 |
| Soliman, MR; Wade, AE | 1 |
| Dingell, JV; Heath, EC; Klausner, HA; Miller, KW | 1 |
| Gilles, FH; Kaplan, ML; Murphy, SD | 1 |
| Miranda, CL; Webb, RE | 1 |
| Back, KC; Murphy, JP; Van Stee, EW | 1 |
| Janiak, B; Kessler, B; Kunz, W; Schnieders, B | 1 |
| Bush, MT; Gerber, N; Holcomb, RR | 1 |
| Archakov, AI; Kretovich, VL; Melik-Sarkisian, SS; Raĭkhinshteĭn, MV | 2 |
| Prabhu, VG | 1 |
| Oester, YT; Prabhu, VG; Rise, NL | 1 |
| Stawarz, RJ; Stitzel, RE; Wagner, LA | 1 |
| McPhillips, JJ; Stevens, JT; Stitzel, RE | 1 |
| Kamataki, T; Kitada, M; Kitagawa, H | 1 |
| Jung, F; Lange, P | 1 |
| Casida, JE; Engel, JL; Matthews, HB; Skrinjarić-Spoljar, M | 1 |
| Kappas, A; Poland, A | 1 |
| Kato, R; Oshima, T; Takayanagi, M | 1 |
| Blackham, A; Spencer, PS | 1 |
| Levine, WG | 1 |
| Mannering, GJ; Stitzel, RE; Tephly, TR | 1 |
| Calderoni, FJ; Mitoma, C; Neubauer, SE; Tagg, JS; Tanabe, M; Yasuda, D | 1 |
| Anders, MW | 1 |
| Arnold, K; Gerber, N | 1 |
| Anders, MW; Furner, RL; McCarthy, JS; Stitzel, RE | 1 |
| Catanese, B; Del Basso, P; Silvestrini, B | 1 |
| Bousquet, WF; Hoffman, DG; Miya, TS | 1 |
| Avnimelech, M; Jondorf, WR; Simon, DC | 1 |
| Anders, MW; Mannering, GJ; Stitzel, RE | 1 |
| Anders, MW; Mannering, GJ | 1 |
| Bogush, TA; Sitdikova, SM | 1 |
| Islam, SI; Zaher, FA | 1 |
| Ando, R; Kisara, K; Ogura, Y; Onodera, K; Sakurada, S; Tadano, T; Takahashi, N | 1 |
| Islam, SI | 1 |
| Bogush, TA; Donenko, FV; Syrkin, AB | 1 |
| BHAGAT, B; LOCKETT, MF | 1 |
| MANNERING, GJ; RUBIN, A; TEPHYL, TR | 1 |
| CONNEY, AH; JACOBSON, M; KUNTZMAN, R; SCHNEIDMAN, K | 1 |
| FOUTS, JR; ROGERS, LA | 1 |
| CHIESARA, E; KATO, R; VASSANELLI, R | 1 |
3 review(s) available for hexobarbital and proadifen
| Article | Year |
|---|---|
Sex-related differences in drug metabolism.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Estradiol; Female; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Oxidoreductases, N-Demethylating; Pentobarbital; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Proadifen; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet; Strychnine; Testosterone | 1974 |
Factors influencing steroid hydroxylases in liver microsomes.
Topics: Age Factors; Animals; Carbon Isotopes; Chlordan; DDT; Dogs; Estradiol; Guinea Pigs; Hexobarbital; In Vitro Techniques; Insecticides; Liver; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen Consumption; Phenobarbital; Phenylbutazone; Phosphates; Polycyclic Compounds; Proadifen; Progesterone; Rabbits; Rats; Sex Factors; Steroids; Testosterone | 1966 |
Influence of chlorinated hydrocarbons and organophosphate insecticides on metabolism of steroids.
Topics: Animals; Carbon Isotopes; Chlordan; DDT; Desoxycorticosterone; Dichlorodiphenyldichloroethane; Enzyme Induction; Estradiol; Female; Guinea Pigs; Hexobarbital; Hydrocarbons, Halogenated; Hydrocortisone; Insecticides; Liver; Male; Proadifen; Progesterone; Rats; Testosterone; Tyrosine Transaminase | 1969 |
77 other study(ies) available for hexobarbital and proadifen
| Article | Year |
|---|---|
Characterization of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain: comparison with hepatic aminopyrine N-demethylation.
Topics: Aminopyrine N-Demethylase; Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Brain; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Kinetics; Male; Meperidine; Microsomes; Microsomes, Liver; NAD; NADP; Proadifen; Proteins; Rats | 1979 |
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT; Ditiocarb; Drug Interactions; Enzyme Induction; Female; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Phenylbutazone; Proadifen; Rats; Sleep | 1975 |
Measurement of substrate-induced oxygen uptake during microsomal drug oxidation using a gold micro-electrode.
Topics: Animals; Biphenyl Compounds; Cell-Free System; Gold; Hexobarbital; Kinetics; Male; Microelectrodes; Microsomes, Liver; Morphine; Morphine Derivatives; NADP; Naphthalenes; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Polarography; Proadifen; Rats | 1975 |
Modification of carbon tetrachloride hepatotoxicity by chemicals.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cobalt; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Liver Diseases; Male; Methylphenazonium Methosulfate; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenazines; Proadifen; Sleep; Time Factors; Triglycerides | 1977 |
Pharmacokinetic and pharmacodynamic tolerance of a new anticonvulsant agent (3-sulfamoylmethyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin and carbamazepine in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Hexobarbital; Isoxazoles; Kinetics; Male; Oxazoles; Phenobarbital; Phenytoin; Proadifen; Rats; Sleep; Time Factors | 1979 |
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.
Topics: Aging; Amphetamine; Animals; Anticonvulsants; Dextroamphetamine; Hexobarbital; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Phenytoin; Piperonyl Butoxide; Proadifen; Sleep | 1978 |
Hexobarbital sleeping time and drug metabolism in rats with ligated bile ducts--a lack of correlation.
Topics: Animals; Bile Ducts; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Proadifen; Protein Binding; Rats; Sleep; Thiopental; Time Factors; Zoxazolamine | 1976 |
Drug-induced porphyrin biosynthesis-XI. Effect of SKF 525-A on the activity of porphyrin-inducing drugs in chick embryos, chickens and rats.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Chick Embryo; Chickens; Dicarbethoxydihydrocollidine; Drug Interactions; Enzyme Induction; Hexobarbital; Liver; Porphyrins; Proadifen; Rats; Species Specificity; Time Factors | 1976 |
The effect of caffeine on barbiturate sleeping time and brain level.
Topics: Aminopyrine N-Demethylase; Analysis of Variance; Animals; Barbiturates; Brain Chemistry; Caffeine; Drug Interactions; Hexobarbital; Liver; Male; Morphine Derivatives; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Sleep; Time Factors | 1975 |
Effect of repeated exposure to aniline, nitrobenzene, and benzene on liver microsomal metabolism in the rat.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzene; Depression, Chemical; Fever; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitrobenzenes; Oxidoreductases; Phenacetin; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical | 1975 |
The metabolism of benzo(alpha)pyrene in isolated rat liver cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Cells, Cultured; Flavonoids; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rotenone; Solubility; Stimulation, Chemical | 1975 |
The effect of ouabain and digitoxin on hexobarbitone sleeping time in the mouse.
Topics: Animals; Digitoxin; Drug Synergism; Electrocardiography; Heart; Hexobarbital; Male; Microsomes, Liver; Ouabain; Proadifen; Sleep; Time Factors | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors | 1975 |
Circadian rhythms in drug action and drug metabolism in the mouse.
Topics: Adrenal Glands; Adrenalectomy; Animals; Brain; Circadian Rhythm; Hexobarbital; Light; Liver; Male; Meperidine; Mice; Mice, Inbred Strains; Mixed Function Oxygenases; Nerve Tissue Proteins; Nitroanisole O-Demethylase; Proadifen; Time Factors | 1975 |
Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Enzyme Induction; Hexobarbital; Hypoprothrombinemias; Liver; Male; Methaqualone; Phenobarbital; Proadifen; Prothrombin Time; Rats; Sleep; Time Factors; Warfarin | 1976 |
The potentiation of barbiturate-induced narcosis by procarbazine.
Topics: Animals; Barbiturates; Brain; Drug Synergism; Half-Life; Hexobarbital; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Proadifen; Procarbazine; Sleep; Urea | 1976 |
Mechanism of the protective activity of ICRF-187 against alloxan-induced diabetes in mice.
Topics: Alloxan; Animals; Blood Glucose; Chelating Agents; Cimetidine; Diabetes Mellitus, Experimental; Dimethyl Sulfoxide; Hexobarbital; Hyperglycemia; Male; Mice; Mice, Inbred ICR; Piperazines; Proadifen; Razoxane; Sleep; Stereoisomerism; Superoxide Dismutase | 1986 |
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
Topics: Alkaloids; Animals; Aryl Hydrocarbon Hydroxylases; Benzodioxoles; Biological Availability; Dose-Response Relationship, Drug; Ethylmorphine-N-Demethylase; Glucuronosyltransferase; Hexobarbital; Kinetics; Male; Mice; Microsomes, Liver; Paralysis; Pharmaceutical Preparations; Piperidines; Polyunsaturated Alkamides; Proadifen; Rats; Sleep; Zoxazolamine | 1985 |
Inhibition of microsomal drug metabolism by anticholinesterase insecticides.
Topics: Aniline Compounds; Animals; Anisoles; Carbaryl; Cholinesterase Inhibitors; Hexobarbital; In Vitro Techniques; Insecticides; Kinetics; Malathion; Male; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Paraoxon; Parathion; Pharmaceutical Preparations; Proadifen; Rats; Sleep; Spectrophotometry; Time Factors; Zoxazolamine | 1973 |
Drug metabolism by hepatic microsomes from phenobarbital-treated or starved male and female rats in the presence of inhibitors.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Female; Hexobarbital; Liver; Male; Methylation; Microsomes, Liver; Morphinans; Niacinamide; Organ Size; Phenobarbital; Proadifen; Rats; Starvation | 1971 |
[Demonstration of a depressive component in the central effects of nikethamide].
Topics: Animals; Body Temperature; Central Nervous System; Chloral Hydrate; Drug Synergism; Female; Hexobarbital; Hypnotics and Sedatives; Male; Mice; Niacinamide; Nikethamide; Pentobarbital; Proadifen; Sleep; Time Factors; Wakefulness | 1972 |
Modification of hexobarbital metabolism by Morris hepatoma 5123tc.
Topics: Animals; Carcinoma, Hepatocellular; Female; Hexobarbital; In Vitro Techniques; Liver; Liver Neoplasms; Male; Necrosis; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Proadifen; Rats; Sleep | 1967 |
Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.
Topics: Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chloromercuribenzoates; Drug Synergism; Hexobarbital; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NAD; Nitro Compounds; Oxidation-Reduction; Oxygen Consumption; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Phenols; Proadifen; Pyridines; Rats; Spectrophotometry | 1974 |
The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat.
Topics: Aniline Compounds; Animals; Bucladesine; Calcium; Catecholamines; Epinephrine; Half-Life; Hexobarbital; Hypoxia; In Vitro Techniques; Liver; Male; Microsomes, Liver; Norepinephrine; Papaverine; Perfusion; Proadifen; Proteins; Radiography; Rats; Serum Albumin, Bovine; Time Factors | 1974 |
Hepatic glycogen concentration and hexobarbital-sleeping time in mice.
Topics: Animals; Enzymes; Hexobarbital; Histamine H1 Antagonists; Liver; Liver Glycogen; Mice; Microsomes; Piperazines; Proadifen; Sleep | 1966 |
The effect of o,p'DDD on cortisol and hexobarbital metabolism.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Chromatography; Dichlorodiphenyldichloroethane; Hexobarbital; Hydrocortisone; Liver; Male; Microsomes; NADP; Proadifen; Rats | 1966 |
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; Kinetics; Liver; Male; Microsomes; Morphine; NADP; Niacinamide; Oxidation-Reduction; Pigments, Biological; Proadifen; Rats; Sex Factors; Spectrophotometry; Transferases | 1968 |
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Sex Factors; Spectrophotometry; Time Factors; Valerates | 1969 |
Studies on the relationship between the effects of various substances on absorption spectrum of cytochrome P-450 and the reduction of p-nitrobenzoate by mouse liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzoates; Carbon Monoxide; Cytochromes; Ethylamines; Hexobarbital; Imidazoles; In Vitro Techniques; Kinetics; Liver; Male; Mice; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Proadifen; Pyridines; Spectrophotometry | 1969 |
Species difference in the inhibition of drug metabolism by liver microsomes by different inhibitors.
Topics: Aminopyrine; Aniline Compounds; Animals; Cocaine; Depression, Chemical; Drug Antagonism; Ethylamines; Hexobarbital; Histamine H1 Antagonists; Kinetics; Male; Meperidine; Mice; Microsomes, Liver; Morphine; Nitrophenols; Oxidation-Reduction; Pentobarbital; Pharmaceutical Preparations; Phenacetin; Phenylhydrazines; Piperazines; Proadifen; Rabbits; Rats; Species Specificity; Zoxazolamine | 1969 |
Relationship between difference spectra and metabolism. Barbiturates, drug interaction and species difference.
Topics: Acetanilides; Acetates; Amino Alcohols; Aminopyrine; Aniline Compounds; Animals; Barbiturates; Binding Sites; Chemical Phenomena; Chemistry; Chlorpromazine; Cytochromes; Drug Antagonism; Drug Synergism; Ethanolamines; Hexobarbital; Macaca; Male; Mice; Microsomes, Liver; Pentobarbital; Phenobarbital; Proadifen; Propranolol; Protein Binding; Rats; Sleep; Species Specificity; Spectrophotometry; Thiazoles; Tremorine | 1970 |
[Potentiation of hexobarbital action as a method for experimental research on substances with depressive central activity].
Topics: Animals; Anticonvulsants; Central Nervous System; Female; Hexobarbital; Histamine H1 Antagonists; Hypnotics and Sedatives; Hypoglycemic Agents; Mice; Muscle Relaxants, Central; Proadifen; Sleep; Tranquilizing Agents | 1972 |
The effect of stimulants and depressants of reticuloendothelial activity on drug metabolism.
Topics: Animals; Brain; Depression, Chemical; Drug Synergism; Hexobarbital; Iproniazid; Liver; Male; Metabolic Clearance Rate; Mice; Mononuclear Phagocyte System; Phagocytosis; Piperazines; Proadifen; Pyrans; Sleep; Stimulation, Chemical; Zymosan | 1971 |
The binding of microsomal hydroxylation substrates to cytochrome P-450Rh and its effect on the nitrogen fixation by lupin bacteroids.
Topics: Aniline Compounds; Binding Sites; Camphor; Cytochrome P-450 Enzyme System; Hexobarbital; Hydrogen-Ion Concentration; Metyrapone; Microsomes; Nitrogen Fixation; Plants; Proadifen; Protein Binding; Rhizobium; Spectrophotometry; Spectrophotometry, Ultraviolet; Ultracentrifugation | 1974 |
Cytochrome P-450-linked monooxygenase system and drug-induced spectral interactions in human liver microsomes.
Topics: Amines; Aniline Compounds; Animals; Antimetabolites; Benzene Derivatives; Butanols; Carbon Monoxide; Cholelithiasis; Cyanides; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Guinea Pigs; Hexobarbital; Humans; Liver; Microsomes, Liver; Oxygenases; Phenacetin; Proadifen; Rabbits; Rats; Smoking; Species Specificity; Spectrophotometry | 1974 |
Potent inhibitory action of pilocarpine on hepatic drug metabolism.
Topics: Aniline Compounds; Animals; Depression, Chemical; Ethylamines; Glucosephosphate Dehydrogenase; Hexobarbital; Imipramine; In Vitro Techniques; Liver; Male; Nicotine; Phenols; Pilocarpine; Proadifen; Rabbits; Spectrophotometry; Tritium | 1972 |
Interaction of the imidazolone derivative GPA 1851 with hepatic microsomal drug metabolism.
Topics: Animals; Anti-Inflammatory Agents; Barbiturates; Benzene Derivatives; Benzopyrenes; Dogs; Drug Interactions; Drug Synergism; Female; Haplorhini; Hexobarbital; Hydroxylation; Imidazoles; Kinetics; Macaca; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Proadifen; Rats; Sleep; Time Factors | 1972 |
Effect of puromycin on binding and on metabolism in vitro of substrates by rat liver microsomes.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Proadifen; Protein Binding; Puromycin; Rats; Spectrophotometry | 1972 |
The intracellular localization of 9 -tetrahydrocannabinol in liver and its effects on drug metabolism in vitro.
Topics: Aminopyrine; Animals; Benzoates; Cannabis; Carbon Isotopes; Cell Nucleus; Dealkylation; Dronabinol; Estradiol; Glucuronates; Hexobarbital; Hexosyltransferases; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Mitochondria, Liver; Nitrophenols; Oxidation-Reduction; Pharmaceutical Preparations; Proadifen; Rats; Tritium | 1973 |
Modification of acrylamide neuropathy in rats by selected factors.
Topics: Acrylamides; Adrenal Glands; Adrenalectomy; Age Factors; Animals; DDT; Enzyme Induction; Hexobarbital; Hydrocortisone; In Vitro Techniques; Liver; Male; Microsomes, Liver; Motor Activity; Myelin Sheath; Neurons; Oxidoreductases; Peripheral Nerves; Phenobarbital; Proadifen; Rats; Thiamine Deficiency; Time Factors; Vitamin B 6 Deficiency | 1973 |
Effects of dietary protein quality on drug metabolism in the rat.
Topics: Anesthesia; Aniline Compounds; Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Dealkylation; Dietary Proteins; Drug Synergism; Glutens; Hexobarbital; Hydroxylation; Liver; Male; Microsomes, Liver; Morphinans; Organ Size; Phenobarbital; Proadifen; Proteins; Rats; Time Factors | 1973 |
Effect of dibromotetrafluoroethane inhalation on hepatic drug metabolism in mice.
Topics: Animals; Chlorofluorocarbons, Methane; Drug Interactions; Hexobarbital; Hydrocarbons, Halogenated; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Paralysis; Phenobarbital; Proadifen; Respiration; Sleep; Time Factors; Zoxazolamine | 1973 |
[The effect of silymarine on contents and functions of some microsomal liver enzymes influenced by carbon tetrachloride or halothane].
Topics: Alcohols; Aniline Compounds; Animals; Binding, Competitive; Carbon Tetrachloride Poisoning; Chromatography, Paper; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport; Flavonoids; Flavoproteins; Halothane; Hexobarbital; Malate Dehydrogenase; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oxidoreductases, N-Demethylating; Proadifen; Rats; Sleep; Triglycerides | 1973 |
The metabolic fate of hexobarbital in the rat.
Topics: Animals; Bile; Carbon Radioisotopes; Countercurrent Distribution; Feces; Half-Life; Hexobarbital; Hydroxylation; In Vitro Techniques; Ketones; Kidney; Kinetics; Liver; Male; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry, Ultraviolet; Time Factors; Urea | 1974 |
[Spectral properties of cytochrome P-450 from lupin nodule bacteroids].
Topics: Aniline Compounds; Animals; Camphor; Cytochrome P-450 Enzyme System; Hexobarbital; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rhizobium; Spectrophotometry | 1974 |
[Effect of substrates and microsomal hydroxylation inhibitors on the nitrogen-fixing activity of lupin bacteroids].
Topics: Aniline Compounds; Camphor; Cytochrome P-450 Enzyme Inhibitors; Hexobarbital; Metyrapone; Nitrogen Fixation; Oxygen Consumption; Proadifen; Rhizobium | 1974 |
Amphetamine aggregation effect in mice under conditions of altered microsomal enzymes.
Topics: Amphetamine; Animals; Behavior, Animal; Chlordan; Crowding; Drug Synergism; Enzyme Induction; Hexobarbital; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Microsomes; Phenobarbital; Proadifen; Sleep; Social Isolation | 1972 |
The effect of experimental local inflammation on the action of barbiturates in rat.
Topics: Animals; Barbiturates; Carbon Tetrachloride; Carrageenan; Charcoal; Chlordan; Enzyme Induction; Gossypium; Hexobarbital; Inflammation; Injections, Subcutaneous; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sleep; Time Factors; Yeasts | 1972 |
Studies on the microsomal metabolism of 3 H-reserine.
Topics: Aniline Compounds; Animals; Benzoates; Hexobarbital; In Vitro Techniques; Kinetics; Male; Meperidine; Methyl Ethers; Mice; Mice, Inbred Strains; Microsomes, Liver; Mitochondria, Liver; Proadifen; Proteins; Reserpine; Tritium | 1972 |
In vitro enhancement of aniline metabolism by paraoxon.
Topics: Acetone; Aniline Compounds; Animals; Dogs; Hexobarbital; Humans; Insecticides; Kinetics; Mice; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitrophenols; Paraoxon; Proadifen; Rabbits; Rats; Species Specificity; Stimulation, Chemical | 1972 |
Substrate induced difference spectrum of microsomal P-450 in human liver.
Topics: Aminopyrine; Aniline Compounds; Hexobarbital; Humans; Microsomes, Liver; Pigments, Biological; Proadifen; Spectrophotometry | 1971 |
[Reduction of liver toxicity of carbon tetrachloride by diethyl thiocarbamate and 3-(O-tolyl)-4-(nitro)-syndnon].
Topics: Anesthesia, Intravenous; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Hexobarbital; Liver; Liver Function Tests; Mice; Mice, Inbred Strains; Oxadiazoles; Proadifen; Sulfobromophthalein; Thiocarbamates; Triglycerides | 1971 |
Response of hepatic microsomal mixed-function oxidases to various types of insecticide chemical synergists administered to mice.
Topics: Alkynes; Aniline Compounds; Animals; Anisoles; Benzopyrans; Carbamates; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dimethyl Sulfoxide; Dioxoles; Drug Synergism; Enzyme Induction; Ethers; Hexobarbital; Hydrocarbons, Halogenated; Hydroxylation; In Vitro Techniques; Indoles; Insecticides; Male; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Organophosphorus Compounds; Organothiophosphorus Compounds; Oxidoreductases; Pesticide Synergists; Pesticides; Piperonyl Butoxide; Proadifen; Pyrazoles; Rotenone; Sleep; Spectrophotometry; Sulfites; Thiadiazoles; Time Factors | 1971 |
The metabolism of aminopyrine in chick embryo hepatic cell culture: effects of competitive substrates and carbon monoxide.
Topics: Aminopyrine; Animals; Antipyrine; Carbon Monoxide; Cells, Cultured; Chick Embryo; Dealkylation; Fatty Acids; Hexobarbital; Intestinal Mucosa; Kidney; Kinetics; Liver; Oxygen Consumption; Piperonyl Butoxide; Proadifen; Testosterone | 1971 |
Differences in the oxidative metabolism of drugs by liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Oxidoreductases; Pentobarbital; Phenobarbital; Proadifen; Rats; Sex Factors; Starvation; Thyroxine; Zoxazolamine | 1969 |
The effects of oestrogens and progestins on the response of mice to barbiturates.
Topics: Animals; Barbiturates; Body Temperature; Drug Synergism; Female; Hexobarbital; Lynestrenol; Male; Mestranol; Mice; Pentobarbital; Proadifen; Sleep; Time Factors | 1969 |
Effect of SKF 525-A on biliary function. Influence of body temperature.
Topics: Animals; Bile; Biliary Tract; Body Temperature; Drug Synergism; Female; Hexobarbital; Pentobarbital; Proadifen; Rats | 1970 |
Inhibition of drug metabolism. VI. Inhibition of hexobarbital metabolism in the isolated perfused liver of the rat.
Topics: Animals; Chlorpromazine; Codeine; Hexobarbital; In Vitro Techniques; Liver; Male; Morphine; Narcotics; Proadifen; Rats | 1968 |
Effects of various chemical agents on drug metabolism and cholesterol biosynthesis.
Topics: Acetanilides; Acetates; Aminopyrine; Animals; Anticholesteremic Agents; Benzopyrenes; Carbon Isotopes; Chloramphenicol; Cholesterol; Depression, Chemical; Drug Synergism; Ethers; Ethylamines; Hexobarbital; Insecticides; Iproniazid; Liver; Male; Mevalonic Acid; Microsomes; Nitrophenols; Phenobarbital; Proadifen; Rabbits; Rats; Sleep; Time Factors | 1968 |
Inhibition of microsomal drug metabolism by methylenedioxybenzenes.
Topics: Aniline Compounds; Animals; Benzene Derivatives; Depression, Chemical; Dioxoles; Drug Synergism; Enzyme Induction; Glucosephosphate Dehydrogenase; Hexobarbital; Insecticides; Isocitrate Dehydrogenase; Liver; Male; Mice; Microsomes; Morphine; Proadifen; Rats; Sleep; Time Factors | 1968 |
Studies on the metabolism of diphenylhydantoin in mice.
Topics: Animals; Cycloheximide; Cytochromes; Hexobarbital; Hydroxyzine; Kinetics; Liver; Male; Mice; Microsomes; Organ Size; Paralysis; Phenytoin; Proadifen; Sleep; Zoxazolamine | 1969 |
Stereoselective metabolism of the enantiomers of hexobarbital.
Topics: Animals; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Sex Factors; Sleep; Stereoisomerism; Time Factors | 1969 |
Researches on the increase of liver weight produced by some drugs.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chlorpromazine; Hexobarbital; Liver; Mice; Organ Size; Phenylbutazone; Proadifen; Sulfobromophthalein | 1966 |
Lycorine inhibition of drug metabolism and ascorbic acid biosynthesis in the rat.
Topics: Alkaloids; Amines; Animals; Ascorbic Acid; Barbiturates; Hexobarbital; In Vitro Techniques; Liver; Meprobamate; Pentobarbital; Proadifen; Rats | 1966 |
Further studies on the stimulation of L-(14C)-amino acid incorporation with cycloheximide.
Topics: Aminopyrine; Aniline Compounds; Animals; Antifungal Agents; Antipyrine; Body Weight; Carbon Isotopes; Cycloheximide; Female; Growth; Hexobarbital; In Vitro Techniques; Liver; Magnesium; Microsomes; Organ Size; Phenylalanine; Proadifen; Rats; RNA; RNA, Messenger; Sleep; Sulfonamides | 1966 |
Inhibition of drug metabolism. 3. Inhibition of hexobarbital metabolism in the intact rat and in the isolated perfused liver by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and its N-deethylated derivatives.
Topics: Animals; Enzymes; Hexobarbital; In Vitro Techniques; Liver; Male; Microsomes; Perfusion; Proadifen; Rats; Sleep | 1966 |
Inhibition of drug metabolism. IV. Induction of drug metabolism by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and 2,4-dichloro-6-phenylphenoxyethylamine HBr (Lilly 18947) and the effect of induction on the inhibitory properties of SKF 525-A
Topics: Animals; Antimetabolites; Enzymes; Hexobarbital; Male; Microsomes; Morphine; Phenobarbital; Proadifen; Proteins; Rats | 1966 |
[Liver mono-oxygenases and the pharmacodynamics of carminomycin and rubomycin].
Topics: Animals; Carubicin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Induction; Hexobarbital; Liver; Male; Mice; Mice, Inbred CBA; Oxygenases; Phenobarbital; Proadifen; Sleep; Time Factors | 1984 |
Inhibition of lipid peroxide decomposition by compounds which bind with cytochrome p-450.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Lipid Peroxides; Male; Microsomes, Liver; Peroxidases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1983 |
[The effect of thiamine deficiency on the actions of drugs affecting the central nervous system in rats (author's transl)].
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Brain; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Hypothalamus; Male; Neurons; Phenobarbital; Proadifen; Rats; Sleep; Tetrabenazine; Thiamine Deficiency | 1980 |
The effect of various modifiers on rat microsomal peroxidase kinetics.
Topics: Aniline Compounds; Animals; Hexobarbital; Kinetics; Lipid Peroxides; Male; Microsomes, Liver; Peroxidases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1982 |
[Activity of nonspecific hepatic oxidases and the biological effects of the antineoplastic antibiotic adriamycin].
Topics: Animals; Doxorubicin; Hexobarbital; Liver; Male; Mice; Mice, Inbred CBA; Oxidoreductases; Phenobarbital; Proadifen; Sleep | 1981 |
THE INDUCTION OF MICROSOMAL ENZYMES; SOME SIGNIFICANT DEVELOPMENTS.
Topics: Accidents; Accidents, Occupational; Androsterone; Hexobarbital; Industry; Proadifen | 1964 |
INHIBITION OF HEXOBARBITAL METABOLISM BY ETHYLMORPHINE AND CODEINE IN THE INTACT RAT.
Topics: Acetanilides; Antimetabolites; Antitussive Agents; Blood; Codeine; Ethylmorphine; Hexobarbital; Meprobamate; Morphine; Pharmacology; Proadifen; Rats; Research | 1964 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmacology; Phenobarbital; Proadifen; Rats; Research; Sex; Steroid Hydroxylases; Testosterone | 1964 |
SOME OF THE INTERACTIONS OF SKF 525-A WITH HEPATIC MICROSOMES.
Topics: Aminopyrine; Codeine; Dialysis; Fatty Acids; Hexobarbital; Iproniazid; Liver; Liver Glycogen; Metabolism; Microsomes; Microsomes, Liver; Proadifen; Rats; Renal Dialysis; Research | 1964 |
Stimulating effect of some inhibitors of the drug metabolisms (SKF 525 A, Lilly 18947, Lilly 32391 and MG 3062) on excretion of ascorbic acid and drug metabolisms.
Topics: Antineoplastic Agents; Ascorbic Acid; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Ethylamines; Hexobarbital; Meprobamate; Muscle Relaxants, Central; Proadifen; Strophanthins | 1962 |