hexobarbital and phenytoin

hexobarbital has been researched along with phenytoin in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199033 (84.62)18.7374
1990's1 (2.56)18.2507
2000's4 (10.26)29.6817
2010's1 (2.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Caron, G; Ermondi, G1
Abraham, MH; Acree, WE; Ibrahim, A1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Brodeur, J; Côte, MG; Gascon-Barré, M1
Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K1
Franklin, MR; James, RC1
Carrer, H; Meyerson, BJ1
Bhattacharya, SK; Ghosal, S; Reddy, PK; Sharma, PV; Singh, AK1
Latham, AN; Sweeney, GD1
Breyer, U; Villumsen, D1
Becker, BA; Gut, I1
Gerber, N; Hilliard, JB; Mays, DC; Nawoot, S; Pacula, CM1
Hanano, M; Harashima, H; Iga, T; Sawada, Y; Sugiyama, Y1
McClain, RM; Rohrs, JM1
Estabrook, RW; Greim, H; Remmer, H; Schenkman, J1
Greengard, P; Quinn, GP; Reid, MB1
Arnold, K; Gerber, N2
Mandel, HG; Riis, M1
Falk, M; Fürst, W1
Cely, W; Karler, R; Turkanis, SA1
Brückner, UB; Deuster, JE; Hoyer, S; Mast, GJ; Mittmann, U; Schmidt, HD; Schmier, J; van Ackern, K1
Bacci, MC; Bianchi, C; Bonardi, G; Coppi, G; Molino, C; Tomasi, L; Vidi, A1
Kostenbauder, HB; Lubawy, WC; Stavchansky, SA1
Nebert, DW; Robinson, JR1
Bartl, P; Dalton, C; Kamm, JJ1
Remmer, H1
Kemp, JW; Swinyard, EA; Tannhauser, M1
Becker, BA; Eling, TE; Fouts, JR; Harbison, RD1
Fukuda, T; Katsuda, N; Tanaka, K1
Krimsley, V; Shaffer, JW; Steinberg, E; Winstead, WB1
Costa, E; Groppetti, A1
Noordhoek, J; Rümke, CL1
Ilczuk, I; Rabsztyn, T; Rump, S; Walczyna, K1
Breimer, DD; Richter, E; Zilly, W1
Gelboin, HV; Kim, ND; Park, SS; Won, SM; Yoo, JK1
Afshari, CA; Barrett, JC; Bennett, L; Blanchard, K; Bushel, PR; DiSorbo, O; Hamadeh, HK; Jayadev, S; Li, L; Paules, RS; Stoll, R; Tennant, R1
BURNS, JJ1

Reviews

1 review(s) available for hexobarbital and phenytoin

ArticleYear
IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY.
    The American journal of medicine, 1964, Volume: 37

    Topics: Animals; Benzopyrenes; Cyclizine; Dicumarol; Diphenhydramine; Dogs; Drug Therapy; Enzyme Induction; Enzymes; Glutethimide; Hexobarbital; Liver; Meprobamate; Metabolism; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Probenecid; Rats; Research; Tolbutamide; Toxicology; Zoxazolamine

1964

Other Studies

38 other study(ies) available for hexobarbital and phenytoin

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Hepatic drug metabolism after phenobarbital and diphenylhydantoin administration in the rat--influence of vitamin D3 status.
    Biochemical pharmacology, 1979, Volume: 28, Issue:2

    Topics: Animals; Calcium; Cholecalciferol; Hexobarbital; Liver; Male; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Phosphorus; Rats; Sleep; Time Factors; Vitamin D Deficiency

1979
Pharmacokinetic and pharmacodynamic tolerance of a new anticonvulsant agent (3-sulfamoylmethyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin and carbamazepine in rats.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 240, Issue:1

    Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Hexobarbital; Isoxazoles; Kinetics; Male; Oxazoles; Phenobarbital; Phenytoin; Proadifen; Rats; Sleep; Time Factors

1979
The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.
    Toxicology and applied pharmacology, 1978, Volume: 44, Issue:1

    Topics: Aging; Amphetamine; Animals; Anticonvulsants; Dextroamphetamine; Hexobarbital; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Phenytoin; Piperonyl Butoxide; Proadifen; Sleep

1978
Effect of CNS depressants and stimulants on latency for the appearance of copulatory response in the female rat.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 4, Issue:5

    Topics: 20-alpha-Dihydroprogesterone; Adrenal Glands; Animals; Copulation; Estradiol; Ether; Female; Hexobarbital; Ovary; Phenytoin; Picrotoxin; Rats; Strychnine; Time Factors

1976
Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin.
    Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:10

    Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Depression, Chemical; Drug Interactions; Glucosides; Glycosides; Hexobarbital; Iridoid Glucosides; Mice; Morphine; Motor Skills; Phenytoin; Plant Extracts; Plants, Medicinal; Pyrans; Pyrones; Rats; Sleep; Xanthenes; Xanthones

1976
Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes.
    Canadian journal of physiology and pharmacology, 1976, Volume: 54, Issue:6

    Topics: Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Glucaric Acid; Hexobarbital; In Vitro Techniques; Kinetics; Male; Mephenytoin; Microsomes, Liver; Phenobarbital; Phenylbutyrates; Phenytoin; Rats; Receptors, Drug; Urea

1976
Thin-layer chromatographic determination of barbiturates and phenytoin in serum and blood.
    Journal of chromatography, 1975, Dec-24, Volume: 115, Issue:2

    Topics: Animals; Barbiturates; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Hexobarbital; Humans; Kinetics; Phenobarbital; Phenytoin; Rats

1975
Diphenylhydantoin effects on hexobarbital and aniline biotransformation in male rats: differences between in vitro and in vivo observations.
    Toxicology and applied pharmacology, 1975, Volume: 34, Issue:2

    Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Hexobarbital; In Vitro Techniques; Liver; Male; Microsomes, Liver; Organ Size; Phenytoin; Rats; Time Factors

1975
Inhibition and induction of drug biotransformation in vivo by 8-methoxypsoralen: studies of caffeine, phenytoin and hexobarbital metabolism in the rat.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Animals; Biotransformation; Caffeine; Hexobarbital; Male; Methoxsalen; Phenytoin; Rats; Rats, Inbred Strains

1987
Prediction of serum concentration time course of quinidine in human using a physiologically based pharmacokinetic model developed from the rat.
    Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:2

    Topics: Animals; Antipyrine; Half-Life; Hexobarbital; Humans; Kidney; Kinetics; Liver; Metabolic Clearance Rate; Models, Biological; Phenytoin; Quinidine; Rats; Time Factors

1986
Potentiation of the teratogenic effects and altered disposition of diphenylhydantoin in mice fed a purified diet.
    Toxicology and applied pharmacology, 1985, Volume: 77, Issue:1

    Topics: Analysis of Variance; Animals; Cleft Palate; Congenital Abnormalities; Diet; Female; Fetus; Hexobarbital; Mice; Phenytoin; Pregnancy; Sleep

1985
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action.
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 259, Issue:2

    Topics: Aniline Compounds; Animals; Antipyrine; Benzopyrenes; Cytochromes; Dicumarol; Electron Transport; Enzyme Induction; Hexobarbital; Kinetics; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Protein Binding; Prothrombin Time

1968
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
    Molecular pharmacology, 1966, Volume: 2, Issue:4

    Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine

1966
The effect of diphenyl-piperazine compounds and other agents on diphenylhydantoin, zoxazolamine and hexobarbital metabolism.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 164, Issue:1

    Topics: Animals; Benzopyrenes; Cyclizine; DDT; Diphenhydramine; Endoplasmic Reticulum; Hexobarbital; Humans; Hydroxyzine; Liver; Male; Meclizine; Methylcholanthrene; Mice; Microscopy, Electron; Phenethylamines; Phenobarbital; Phenytoin; Piperazines; Trifluoperazine; Zoxazolamine

1968
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
    Biochemical pharmacology, 1970, Volume: 19, Issue:6

    Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea

1970
[Drug permeation through synthetic lipid membranes. Permeability of lecithin-collodium membranes for drugs and metabolites].
    Die Pharmazie, 1974, Volume: 29, Issue:9

    Topics: Buffers; Caffeine; Diffusion; Hexobarbital; Hydrogen-Ion Concentration; Kinetics; Membranes, Artificial; Models, Chemical; Papaverine; Phenobarbital; Phenytoin; Phosphatidylcholines; Quinine; Salicylates; Solutions; Time Factors

1974
A study of the development of tolerance to an anticonvulsant effect of delta9-tetrahydrocannabinol and cannabidiol.
    Research communications in chemical pathology and pharmacology, 1974, Volume: 9, Issue:1

    Topics: Animals; Anticonvulsants; Cannabis; Dronabinol; Drug Interactions; Drug Synergism; Drug Tolerance; Electroshock; Hexobarbital; Male; Mice; Mice, Inbred ICR; Phenobarbital; Phenytoin; Resorcinols; Sleep; Terpenes; Time Factors

1974
[Negative inotropic effects of hexobarbital, diphenylhydantoin, propanidid and chlormethiazole on the previously damaged heart (author's transl)].
    Zeitschrift fur praktische Anasthesie, Wiederbelebung und Intensivtherapie, 1973, Volume: 8, Issue:4

    Topics: Animals; Child; Chlormethiazole; Depression, Chemical; Dogs; Female; Heart; Hemodynamics; Hexobarbital; Humans; Male; Middle Aged; Phenytoin; Propanidid

1973
Experimental models for the in vivo evaluation of enzyme induction properties of drugs.
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:12

    Topics: Acetanilides; Amides; Aminopyrine; Amphetamine; Aniline Compounds; Animals; Central Nervous System; Codeine; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Hexobarbital; Male; Meperidine; Mice; Oxotremorine; Pentobarbital; Phenacetin; Phenytoin; Rabbits; Rats; Strychnine; Tolbutamide; Tremorine; Zoxazolamine

1973
Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin.
    Life sciences, 1974, Apr-16, Volume: 14, Issue:8

    Topics: Animals; Drug Interactions; Hexobarbital; Liver; Male; Morphinans; Phenytoin; Rats; Sleep; Time Factors

1974
Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism.
    Molecular pharmacology, 1974, Volume: 10, Issue:3

    Topics: Animals; Benzopyrenes; Carbon Radioisotopes; Crosses, Genetic; Flavonoids; Hexobarbital; Hydrocarbons; Liver; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mixed Function Oxygenases; Molecular Biology; Phenytoin; Sleep; Time Factors; Zoxazolamine

1974
5,5'-Diphenyl-2-thiohydantoin (DPTH): an inducer of microsomal drug-metabolizing enzymes.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 182, Issue:3

    Topics: Animals; Cytochromes; Electron Transport; Endoplasmic Reticulum; Enzyme Induction; Hexobarbital; Liver; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Microsomes, Liver; Organ Size; Phenobarbital; Phenytoin; Proteins; Rats; Rats, Inbred Strains; Sleep; Sulfides; Time Factors

1972
[Changes of drug effects caused by their metabolism in the liver].
    Monatsschrift fur Kinderheilkunde, 1971, Volume: 119, Issue:7

    Topics: Aminopyrine; Animals; Cytochromes; Dogs; Drug Stability; Endoplasmic Reticulum; Female; Fetus; Hexobarbital; Humans; Liver; Male; Metabolism; Mice; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Pregnancy; Rabbits; Rats; Thiopental

1971
Effect of diphenylhydantoin on hexobarbital sleep time in mice and rats.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 193, Issue:1

    Topics: Animals; Depression, Chemical; Hexobarbital; In Vitro Techniques; Male; Mice; Microsomes, Liver; Nervous System; Phenytoin; Rats; Sleep; Time Factors

1971
Diphenylhydantoin effect on neonatal and adult rat hepatic drug metabolism.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 171, Issue:1

    Topics: Age Factors; Aminopyrine; Aniline Compounds; Animals; Animals, Newborn; Benzoates; Benzopyrenes; Benzphetamine; Body Weight; Cytochromes; Hexobarbital; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Organ Size; Phenytoin; Proteins; Rats

1970
Discharge patterns of single reticular neuron synchronized with electrocortical spike induced by pentetrazol.
    The Tohoku journal of experimental medicine, 1970, Volume: 100, Issue:1

    Topics: Animals; Electroencephalography; Female; Hexobarbital; Injections, Intravenous; Lidocaine; Male; Neurons; Pentylenetetrazole; Phenytoin; Rats; Reticular Formation

1970
Substitution in the hydantoin ring. VII. N-3-Propionic acid and its ethyl ester and N-3-(2-cyanoethyl) derivatives.
    Journal of medicinal chemistry, 1968, Volume: 11, Issue:3

    Topics: Alkylation; Animals; Drug Synergism; Electroshock; Hexobarbital; Hydantoins; Infrared Rays; Magnetic Resonance Spectroscopy; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Propionates; Spectrum Analysis; Ultraviolet Rays

1968
Studies on the metabolism of diphenylhydantoin in mice.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 167, Issue:1

    Topics: Animals; Cycloheximide; Cytochromes; Hexobarbital; Hydroxyzine; Kinetics; Liver; Male; Mice; Microsomes; Organ Size; Paralysis; Phenytoin; Proadifen; Sleep; Zoxazolamine

1969
Factors affecting the rate of disappearance of amphetamine in rats.
    International journal of neuropharmacology, 1969, Volume: 8, Issue:3

    Topics: Age Factors; Animals; Dextroamphetamine; Estradiol; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Sex Factors; Time Factors; Zoxazolamine

1969
The influence of lynestrenol on the rate of metabolism of phenobarbital, phenytoin and hexobarbital in mice.
    European journal of pharmacology, 1969, Volume: 6, Issue:2

    Topics: Animals; Bemegride; Electroshock; Enzyme Induction; Female; Hexobarbital; Lynestrenol; Male; Mice; Phenobarbital; Phenytoin; Seizures; Sleep; Time Factors

1969
Pharmacological properties of N-aminodiphenylhydantoin, a new hydantoin derivative with anticonvulsant activity.
    Die Pharmazie, 1981, Volume: 36, Issue:11

    Topics: Animals; Anticonvulsants; Drug Interactions; Electroshock; Female; Hexobarbital; Lethal Dose 50; Mice; Motor Activity; Phenytoin; Sleep

1981
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents.
    European journal of clinical pharmacology, 1980, Volume: 17, Issue:3

    Topics: Adult; Aged; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Enzyme Induction; Female; Hexobarbital; Humans; Inactivation, Metabolic; Kinetics; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Phenytoin; Rifampin

1980
Phenytoin induction of cytochrome P4502B in mice: effects on hexobarbital hydroxylase activity.
    Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Immunochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenytoin; Sleep

1993
Prediction of compound signature using high density gene expression profiling.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 67, Issue:2

    Topics: Algorithms; Animals; Computational Biology; Databases, Factual; Diethylhexyl Phthalate; Discriminant Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression Profiling; Genomics; Hexobarbital; Liver; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Phenytoin; Predictive Value of Tests; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Reference Standards; RNA, Messenger; Single-Blind Method; Structure-Activity Relationship; Xenobiotics

2002