hexobarbital has been researched along with phenobarbital in 324 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 309 (95.37) | 18.7374 |
| 1990's | 8 (2.47) | 18.2507 |
| 2000's | 6 (1.85) | 29.6817 |
| 2010's | 1 (0.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, JK; Borne, RF; Rauls, DO | 1 |
| Brent, DA; Henry, DW; Minick, DJ; Sabatka, JJ | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Caron, G; Ermondi, G | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Dubský, H; Hána, K; Pestálovă, M; Pracharová, M | 1 |
| Sies, H | 2 |
| Klinger, W; Muller, D | 2 |
| Airall, AA; Jackson, MJ | 1 |
| Benakis, A; Corthay, J; Dormard, Y; Lévy, JC; Medilanski, P | 1 |
| Krauss, P; Nehls, P; Remmer, H; Synder, R; Witmer, C | 1 |
| Ford, JH; Gopinath, C | 1 |
| Brodeur, J; Côte, MG; Gascon-Barré, M | 1 |
| Jansson, I; Schenkman, JB | 1 |
| Guenthner, TM; Mannering, GJ | 1 |
| Horváth, I; Otani, S; Szeberényi, S; Tihanyi, K | 1 |
| Grimmel, K; Richter, E; Zilly, W | 1 |
| Francis, KT; Hamrick, ME | 1 |
| Kachole, MS; Mahajan, AG; Pawar, SS | 2 |
| Abel, J; Dieter, HH; Ohnesorge, FK | 1 |
| Sato, R; Shimada, T | 1 |
| Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K | 1 |
| Buschmann, J; Joeres, R; Richter, E; Zilly, W | 1 |
| Wenzl, H | 1 |
| Bartoli, GM; Burk, RF; Sies, H; Waydhas, C | 1 |
| Gangolli, SD; Harris, RA; Lake, BG; Longland, RC; Severn, BJ | 1 |
| de Matteis, F; Unseld, A | 1 |
| Baird, MB; Massie, HR; Nicolosi, RJ; Samis, HV | 1 |
| Brachtel, D; Gallenkamp, H; Grün, M; Richter, E | 1 |
| Garg, BD; Kourounakis, P; Kovacs, K; Szabo, S; Tuchweber, B | 1 |
| Carr, GS; Mathur, PP; Reavey-Cantwell, NH; Smyth, RD; Witmer, CM | 1 |
| Adams, HR; Isaacson, EL; Masters, BS | 1 |
| Elliot, S; Gelboin, HV; Waters, HL; Wiebel, FJ | 1 |
| Byers, SO; Friedman, M | 1 |
| Drew, R; Priestly, BG | 1 |
| Chistiakov, VV; Lavretskaia, EF; Libinzon, RE; Mal'dov, DG; Ratnikov, LA | 1 |
| Eggert, W; Grauel, L; Ihle, W; Syllm-Rapoport, I | 1 |
| Gans, JH | 1 |
| Latham, AN; Sweeney, GD | 1 |
| Tannenbaum, SR; Wogan, GN | 1 |
| Aeschbacher, HU; Atkinson, J; Domahidy, B | 1 |
| Klinger, W; Reinicke, C | 2 |
| Jablońska, JK; Piotrowski, JK; Wiśniewska-Knypl, JM | 1 |
| Takagi, M | 1 |
| Boren, JA; Mathur, PP; Reavey-Cantwell, NH; Smyth, RD | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM | 1 |
| Idänpään-Heikkilä, J; Vorne, M | 1 |
| Araki, K; Kaneto, H; Koida, M; Noda, T | 1 |
| Lieber, CS; Pirola, RC | 1 |
| Torrielli, MV; Ugazio, G | 1 |
| Breyer, U; Villumsen, D | 1 |
| Herczeg, T; Mathur, PP; Reavey-Cantwell, NH; Smyth, RD | 1 |
| Brezenoff, HE; Mycek, MJ | 1 |
| Koleva, M; Staneva-Stoytcheva, D | 1 |
| Ishikawa, M; Sasaki, K; Takayanagi, Y | 1 |
| Alila, A; Heavner, JE; Rosenberg, PH | 1 |
| Devor, DE; Henneman, JR; Lubet, RA; Nims, RW | 1 |
| Albert, H; Kast, A; Nishikawa, J; Yabe, T | 1 |
| Breimer, DD; Hofman, PH; van der Graaff, M; Vermeulen, NP | 1 |
| Breimer, DD; de Bree, H; Heij, P; van der Graaff, M; Vermeulen, NP | 1 |
| Antoni, F; Bánhegyi, G; Garzó, T; Mandl, J | 1 |
| Bien, E; Gebert, I; Skorka, G | 1 |
| Borchert, HH; Pfeifer, S; Pipping, H | 1 |
| Edds, GT; Himes, JA; Shetty, SN | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G | 1 |
| Gielen, JE; Goujon, FM; Nebert, DW | 1 |
| Müller, O | 1 |
| Rösen, P; Stier, A | 2 |
| Bock, KW | 1 |
| Kato, R | 3 |
| Cutler, RW; Dudzinski, DS; Markowitz, D | 1 |
| Baron, J; Estabrook, RW; Lambeth, D; Mason, JI; Waterman, M | 1 |
| Conney, AH; Kuntzman, R; Welch, R | 1 |
| Estabrook, RW; Greim, H; Remmer, H; Schenkman, J | 1 |
| Gogolák, G; Liebeswar, G; Stumpf, C | 1 |
| Klissiunis, N; Paradelis, A | 1 |
| Greim, H; Uehleke, H | 1 |
| Greim, G; Hildebrandt, A; Remmer, H | 1 |
| Schenkman, JB | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Wilson, JT | 3 |
| Borowski, R; Schlede, E | 1 |
| Schlede, E | 1 |
| Bousquet, WF; Driever, CW; Miya, TS | 1 |
| Fouts, JR; Morris, HP; Rogers, LA | 1 |
| Kato, R; Takanaka, A | 3 |
| Feuer, G; Granda, V | 1 |
| Heni, N | 1 |
| Heni, N; Remmer, H | 1 |
| Gillette, JR; Stripp, B | 1 |
| Franklin, MR | 1 |
| Baron, J; Estabrook, RW; Ishimura, Y; Peterson, J | 1 |
| Kourounakis, P; Tuchweber, B; Werringloer, J | 1 |
| Illing, HP; Netter, KJ | 1 |
| Hospador, MA; Manthei, RW | 1 |
| Arnold, K; Gerber, N | 1 |
| Degkwitz, E; Staudinger, H; Ullrich, V | 1 |
| Fouts, JR; Peters, MA | 2 |
| Kempfle, B; Reschke, L; Schmidtmann, W | 1 |
| Coon, MJ; Lu, AY; Strobel, HW | 1 |
| Leibman, KC | 1 |
| Donahue, JD; Johnson, RK; Jondorf, WR; Miller, HH | 1 |
| Cohen, JL; Jao, JY | 1 |
| Brauser, B; Sies, H | 1 |
| Kato, R; Omori, Y; Onoda, K; Takanaka, A | 1 |
| Gillette, JR | 2 |
| Grosso, LS; Hospador, MA; Manthei, RW | 1 |
| Topham, JC | 1 |
| Mandel, HG; Riis, M | 1 |
| Petri, G; Pórszász, J; Pórszász-Gibiszer, K | 1 |
| Ernster, L; Jansson, I; Orrenius, S; Schenkman, JB | 1 |
| Stohs, SJ; Talcott, RE | 1 |
| Falk, M; Fürst, W | 1 |
| Brown, BR; Sagalyn, AM; Sipes, IG | 1 |
| Balint, GA | 1 |
| Cely, W; Karler, R; Turkanis, SA | 1 |
| Eggert, W; Grauel, EL; Ihle, W; Syllm-Rapoport, I; Weh, L | 1 |
| Fujimoto, JM | 2 |
| Flanagan, RJ; Withers, G | 1 |
| Conney, AH; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, S | 1 |
| Brachtel, D; Grün, M; Kühn, HA; Richter, E; Zilly, W | 1 |
| Orrenius, S; Schenkman, JB; von Bahr, C | 1 |
| Norred, WP; Wade, AE | 1 |
| Basu, TK; Harris, RG; Stewart, PS; Williams, DC | 1 |
| Bradley, SG; Munson, AE; Rose, WC | 1 |
| Century, B | 1 |
| Gilles, FH; Kaplan, ML; Murphy, SD | 1 |
| Feller, DR; Lubawy, WC | 1 |
| Faupel, RP; Kampf, SC; Seitz, HJ; Tarnowski, W | 1 |
| Miranda, CL; Webb, RE | 1 |
| Kocsis, JJ; Saito, FU; Snyder, R | 1 |
| Rothwell, JD; Sweeney, GD | 1 |
| Back, KC; Murphy, JP; Van Stee, EW | 1 |
| Funcke, AB; Timmerman, H | 1 |
| Kärki, NT; Pelkonen, O | 1 |
| Wagstaff, DD | 1 |
| Brachtel, D; Richter, E; Thiel, H; Zilly, W | 1 |
| Grundin, R; Moldéus, P; Orrenius, S; von Bahr, C | 1 |
| Buzello, W; Scholler, KL; Schöppe, B | 1 |
| Bush, MT; Gerber, N; Holcomb, RR | 1 |
| Greeley, RH | 1 |
| Freundt, KJ; Liebaldt, GP; Sieber, KH | 1 |
| Abdel-Rahman, YM; el-Bagoury, IM; el-Shewy, TM; Hamdy, H; Makarem, F; Talaat, M | 1 |
| Dean, ME; Stock, BH | 1 |
| Brodeur, J; Lacombe, R | 1 |
| Chalabala, M; Lichnerová, I | 1 |
| Fouts, JR | 2 |
| Gautieri, RF; Mitala, JJ | 1 |
| Chedid, A; Nair, V | 1 |
| Prabhu, VG | 2 |
| Neal, RA; Roth, JA | 1 |
| Oester, YT; Prabhu, VG; Rise, NL | 1 |
| Rasmussen, KE; Rasmussen, S; Svendsen, AB | 1 |
| Neal, RA; Schulert, AR; Siami, G | 1 |
| Coubeils, JL; Courrière, P; Pullman, B | 1 |
| Nefedova, ZV; Rudzit, EA; Terekhina, AI | 1 |
| Smith, PB; Wade, AE; Wu, B | 1 |
| Chiesara, E; Vassanelli, P | 1 |
| Bartl, P; Dalton, C; Kamm, JJ | 1 |
| Lavigne, JG; Marchand, C | 1 |
| Hatch, RC | 1 |
| Knabe, J; Strauss, D | 1 |
| Alvares, AP; Kappas, A | 1 |
| Bousquet, WF; Hatfield, GK; Miya, TS | 1 |
| Fiereck, EA; Tietz, NW | 1 |
| De Klainer, EG; Malgor, LA; Verbes, V | 1 |
| Remmer, H | 2 |
| McCarthy, JS; Stitzel, RE | 1 |
| Brodeur, J; Marchand, C | 1 |
| Browne, RK; Possley, LH; Zaroslinski, JF | 1 |
| Feuer, G; Lumb, G; Moddel, G; Sosa-Lucero, JC | 1 |
| Vorne, M | 2 |
| Hansch, C; Martin, YC | 1 |
| Arcos, JC; Argus, MF; Venkatesan, N | 1 |
| Brase, DA; Westfall, TC | 1 |
| Abernathy, CO; Guthrie, FE; Hodgson, E; Philpot, RM | 1 |
| Kato, R; Oshima, T; Takayanagi, M | 1 |
| Donahue, JD; Johnson, RK; Jondorf, WR | 1 |
| Furner, RL; Gram, TE; Stitzel, RE | 2 |
| Gilbert, D | 1 |
| Held, H; von Oldershausen, HF | 1 |
| Einheber, A; Klobukowski, CJ; Wren, RE | 1 |
| Stahl, HJ; Wenzel, M | 1 |
| Kaschnitz, R | 1 |
| Chiesara, E; Conti, F; Meldolesi, J | 1 |
| Jensen, VG; Larsen, SS | 1 |
| Döring, HJ; Olbrisch, RR | 2 |
| Kato, R; Takanaka, A; Takayanaghi, M | 1 |
| LeValley, SE; Mitoma, C | 1 |
| Hilton, J; Sartorelli, AC | 1 |
| Fouts, JR; Hewick, DS | 1 |
| Beuthin, PK; Bousquet, WF | 1 |
| Furner, RL; McCarthy, JS; Stitzel, RE; Van Dyke, K | 1 |
| Clauberg, G | 1 |
| Johnson, EA; Stenger, RJ | 1 |
| Estalbrook, RW; Leibman, KC | 1 |
| Schmiedeberg, W; Thiel, HJ; van Zwieten, PA | 1 |
| Bush, MT; Gerber, N; Holcomb, R; Lynn, R; Weller, WL | 1 |
| Maher, N; Sirois, G | 1 |
| Short, CR; Wagstaff, DJ | 1 |
| Cumming, JF; Mannering, GJ; McClung, HW | 1 |
| Chiesara, E; Conti, F; Fanti, A | 2 |
| Goldman, V | 1 |
| Furner, RL; Stitzel, RE | 1 |
| Kündig, H | 1 |
| Calderoni, FJ; Mitoma, C; Neubauer, SE; Tagg, JS; Tanabe, M; Yasuda, D | 1 |
| Goldstein, JA; Taurog, A | 1 |
| Burgison, RM; Dietz, AJ | 1 |
| Dixon, RL; Willson, VJ | 1 |
| George, WJ; Tephly, TR | 1 |
| Gigon, PL; Gillette, JR; Gram, TE; Greene, FE; Guarino, AM | 1 |
| Dorokhova, VI; Lobanov, VI | 1 |
| Delaunois, AL; Marcus, WL; Sperling, F | 1 |
| Büch, H; Buzello, W; Neurohr, O; Rummel, W | 1 |
| Grosman, IuS; Zaks, AS; Zilbermints, LG | 1 |
| Greim, H; Remmer, H; Schenkman, JB; Zange, M | 1 |
| Becker, BA; Harbison, RD | 1 |
| Culp, HW; Gibson, WR; Marshall, FJ; McMahon, RE; Miller, WM; Mills, J | 1 |
| Costa, E; Groppetti, A | 1 |
| Noordhoek, J; Rümke, CL | 1 |
| Chaplin, MD; Mannering, GJ; Shoeman, DW | 1 |
| Arnold, W; Grützmacher, HF | 1 |
| Anders, MW; Furner, RL; McCarthy, JS; Stitzel, RE | 1 |
| Dickerson, G | 1 |
| Iwainsky, H; Wiezorek, WD | 1 |
| Fouts, JR; Gram, TE | 1 |
| Fouts, JR; Wilson, JT | 2 |
| Wilhjelm, BJ | 1 |
| Aboul-Enein, MN; Ahmed, ZF; el-Darawy, ZI; el-Leithy, SA; el-Naga, MA | 1 |
| Anders, MW; Mannering, GJ | 1 |
| Chiesara, E; Clementi, F; Conti, F; Meldolesi, J | 1 |
| Arias, IM; De Leon, A | 1 |
| Burkman, AM; Jones, WD; Rowe, EJ; Weinswig, MH | 1 |
| Fouts, JR; Gram, TE; Rogers, LA | 1 |
| Breimer, DD; Langendijk, PN; van der Graaff, M; Vermeulen, NP | 1 |
| Jolicoeur, FB; Merkel, AD; Rondeau, DB; Wayner, MJ | 1 |
| Fujimori, K; Inoue, K; Kasuya, Y; Mizokami, K; Omori, Y; Sunouchi, M; Takanaka, A | 1 |
| Fulco, AJ; Kim, BH; Matson, RS; Narhi, LO; Ruettinger, RT | 1 |
| Bogush, TA; Sitdikova, SM | 1 |
| Miyaoka, T; Shirasu, Y; Takahashi, H; Tsuda, S | 1 |
| de Zeeuw, RA; Franke, JP; Wijsbeek, J | 1 |
| Deimling, MJ; Schnell, RC | 1 |
| Matsubara, T; Otsubo, S; Yoshihara, E | 1 |
| Danz, M; Klinger, W; Kob, D; Madry, M; Müller, D | 1 |
| Carini, M; Maffei Facino, R | 1 |
| Islam, SI; Zaher, FA | 1 |
| Ando, R; Kisara, K; Ogura, Y; Onodera, K; Sakurada, S; Tadano, T; Takahashi, N | 1 |
| Balevska, P; Leutchev, S; Russanov, E | 1 |
| Awazu, S; Hanano, M; Igari, Y; Sugiyama, Y | 1 |
| Islam, SI | 1 |
| Lyness, WH; Mycek, MJ | 1 |
| Drew, R; Grygiel, JJ; Rowell, J | 1 |
| Csákváry, G; Frenkl, R; Szeberényi, S | 1 |
| Iyanagi, T; Kobayashi, S; Suzaki, T | 1 |
| Bogush, TA; Donenko, FV; Syrkin, AB | 1 |
| Means, JR; Schnell, RC | 1 |
| Breimer, DD; Richter, E; Zilly, W | 1 |
| Delaforge, M; Ioannides, C; Parke, DV | 1 |
| Fischer, E; Gregus, Z | 1 |
| Heinemeyer, G; Hildebrandt, AG; Nigam, S | 1 |
| Gerstenecker, C; Sies, H | 1 |
| Gancho, VIu; Ivanova, LI; Smirnov, AV | 1 |
| Bosia, S; Cornaglia, E; Ugazio, G | 1 |
| Agrawal, AK; Pampori, NA; Shapiro, BH | 1 |
| Breimer, DD; Groen, K; Jansen, EJ; van Bezooijen, CF | 1 |
| Belitsky, GA; Spiegelman, VS | 1 |
| Lake, BG; Lewis, DF | 1 |
| FISCHER, HD; OELSSNER, W | 1 |
| FUJIMOTO, JM; PLAA, GL | 1 |
| KARAMUSTAFAOGLU, V; LEHMANN, J | 1 |
| BEGUIN, M; FLEURY, C; FROMMEL, E; VON LEDEBUR, I | 1 |
| HINTON, JM | 1 |
| CHIESARA, E; KATO, R; NAKAMURA, Y | 1 |
| LAUENER, H | 1 |
| FRAHM, M; GOTTESLEBEN, A; SOEHRING, K | 1 |
| DIXON, RL; FOUTS, JR; HART, LG; ROGERS, LA | 1 |
| PORGES, E | 1 |
| SCHAEDLICH, M | 1 |
| BEGUIN, M; FAMILY, S; FLEURY, C; FROMMEL, E; LEDEBUR, IV | 1 |
| MANNERING, GJ; RUBIN, A; TEPHLY, TR | 1 |
| KELLEHER, J; ROLLASON, JG | 1 |
| BURNS, JJ | 1 |
| FROMMEL, E; SEYDOUX, J | 1 |
| CONNEY, AH; JACOBSON, M; KUNTZMAN, R; SCHNEIDMAN, K | 2 |
| REMMER, H; SIEGERT, M | 1 |
| BJERRE, S; PORTER, CJ | 1 |
| CHIESARA, E; CLEMENTI, F; CONTI, F | 1 |
| BOUSQUET, WF; MIYA, TS; RUPE, BD | 1 |
| CRAM, RL; FOUTS, JR; JUCHAU, MR | 1 |
| COBB, DP; FUJIMORI, H | 1 |
| BOUSQUET, WF; DRIEVER, CW | 1 |
| TOKI, S; WAKIYA, T; YAMASAKI, R | 1 |
| MERKER, HJ; REMMER, H | 1 |
| ADAMSON, RH; FOUTS, JR; HART, LG; MORRIS, HP | 1 |
| Alavaikko, M; Arvela, P; Vorne, M | 1 |
10 review(s) available for hexobarbital and phenobarbital
| Article | Year |
|---|---|
Environmental N-nitroso compounds: implications for public health.
Topics: Bacteria; Carcinogens; Chemical Phenomena; Chemistry; Environment; Food; Food Preservation; Hexobarbital; Humans; Nitrates; Nitrites; Nitroso Compounds; Oxidation-Reduction; Phenobarbital | 1975 |
Sex-related differences in drug metabolism.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Estradiol; Female; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Oxidoreductases, N-Demethylating; Pentobarbital; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Proadifen; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet; Strychnine; Testosterone | 1974 |
Factors influencing steroid hydroxylases in liver microsomes.
Topics: Age Factors; Animals; Carbon Isotopes; Chlordan; DDT; Dogs; Estradiol; Guinea Pigs; Hexobarbital; In Vitro Techniques; Insecticides; Liver; Mice; Microsomes; Mixed Function Oxygenases; NADP; Oxygen Consumption; Phenobarbital; Phenylbutazone; Phosphates; Polycyclic Compounds; Proadifen; Progesterone; Rabbits; Rats; Sex Factors; Steroids; Testosterone | 1966 |
Developmental pharmacology: a review of its application to clinical and basic science.
Topics: Aging; Androgens; Aniline Compounds; Animals; Estrogens; Ethanol; Female; Fetus; Fluorosis, Dental; Gestational Age; Glutethimide; Hexobarbital; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Infant, Newborn; Infant, Newborn, Diseases; Liver; Male; Niacinamide; Oxidoreductases; Pharmacology; Phenobarbital; Pregnancy; Rabbits; Rats; Tetracycline | 1972 |
Oxygenated cytochrome P-450 as an intermediate in hydroxylation reactions.
Topics: Aniline Compounds; Blood Proteins; Camphor; Chemistry, Organic; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Electron Transport; Hexobarbital; Hydrogen-Ion Concentration; Hydroxylation; Iron; Methylcholanthrene; Microsomes, Liver; Models, Chemical; Models, Structural; Organic Chemistry Phenomena; Oxidation-Reduction; Phenobarbital; Pseudomonas; Spectrophotometry; Spectrum Analysis | 1972 |
Current trends in hepatic response tests.
Topics: Aminopyrine; Animals; Ascorbic Acid; Circadian Rhythm; Cold Temperature; Cytochromes; DDT; Dietary Carbohydrates; Dietary Proteins; Dogs; Enzyme Induction; Guinea Pigs; Hepatomegaly; Hexobarbital; Humans; Hydrocarbons; Liver; Mice; Microsomes, Liver; NADP; Organ Size; Phenobarbital; Rabbits; Rats | 1969 |
[Drugs for rectal application. IV. Absorption of rectally administered drugs].
Topics: Aminohippuric Acids; Aminosalicylic Acids; Aspirin; Emulsions; Hexobarbital; Intestinal Absorption; Lipids; Penicillins; Pharmaceutic Aids; Pharmaceutical Preparations; Phenobarbital; Rectum; Sodium; Solubility; Solvents; Sulfisomidine; Suppositories; Thiopental; Tolbutamide; Water | 1969 |
Microsomes, metabolism and toxicity.
Topics: Animals; Barbiturates; Biotransformation; Carbon Tetrachloride; DDT; Enzyme Induction; Female; Hexobarbital; Male; Methylcholanthrene; Mice; Microsomes, Liver; Pesticides; Phenobarbital; Pituitary Hormones, Anterior; Protein Deficiency; Rabbits; Rats; Steroids; Toxicology | 1969 |
Drugs and taste aversion.
Topics: Animals; Avoidance Learning; Barbital; Barbiturates; Chlordiazepoxide; Chlorides; Chlorpromazine; Hexobarbital; Lithium; Lithium Chloride; Phenobarbital; Psychotropic Drugs; Rats; Taste; X-Rays | 1981 |
IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY.
Topics: Animals; Benzopyrenes; Cyclizine; Dicumarol; Diphenhydramine; Dogs; Drug Therapy; Enzyme Induction; Enzymes; Glutethimide; Hexobarbital; Liver; Meprobamate; Metabolism; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Probenecid; Rats; Research; Tolbutamide; Toxicology; Zoxazolamine | 1964 |
314 other study(ies) available for hexobarbital and phenobarbital
| Article | Year |
|---|---|
Correlation of biological activity and high-pressure liquid chromatographic retention index for a series of propranolol, barbiturate, and anthranilic acid analogues.
Topics: Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Barbiturates; Cell Division; Chromatography, High Pressure Liquid; In Vitro Techniques; Myocardial Contraction; ortho-Aminobenzoates; Propranolol; Rabbits; Rats; Sleep; Solubility | 1979 |
A simplified high-pressure liquid chromatography method for determining lipophilicity for structure-activity relationships.
Topics: Animals; Bacteria; Barbiturates; Biological Assay; Cell Division; Chromatography, High Pressure Liquid; Female; Ovum; Oxygen Consumption; Rabbits; Solubility; Structure-Activity Relationship; Sulfanilamides | 1983 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.
Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
[Determination of barbiturates from biological material].
Topics: Amobarbital; Barbital; Barbiturates; Chromatography, Gas; Forensic Medicine; Hexobarbital; Humans; Hydrogen-Ion Concentration; Pentobarbital; Phenobarbital | 1975 |
Proceedings: Monooxygenase activity and nicotinamide nucleotide systems in perfused rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Liver; NADP; Nicotinamide Mononucleotide; Oxidation-Reduction; Phenobarbital; Rats | 1975 |
Developmental aspects of xenobiotic transformation.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethylmorphine; Female; Glucosephosphates; Hexobarbital; Hydrogen-Ion Concentration; Metyrapone; Microsomes, Liver; NAD; NADP; Niacinamide; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Pregnancy; Rats; Semicarbazides | 1976 |
Transport of heterocyclic acids across rat small intestine in vitro.
Topics: Amobarbital; Animals; Barbital; Barbiturates; Biological Transport; Dimethadione; Hexobarbital; Hydrogen-Ion Concentration; In Vitro Techniques; Jejunum; Male; Oxazoles; Pentobarbital; Phenobarbital; Rats; Secobarbital | 1978 |
[Liver extract effect on liver microsomal system and on an experimental model of intoxication].
Topics: Animals; Carbon Tetrachloride Poisoning; Enzyme Induction; Hexobarbital; Liver Extracts; Male; Microsomes, Liver; Phenobarbital; Rats; Sleep | 1977 |
Optical and electron paramagnetic resonance studies of partially purified rabbit liver cytochrome P-450.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Electron Spin Resonance Spectroscopy; Hexobarbital; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Spectrum Analysis | 1975 |
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT; Ditiocarb; Drug Interactions; Enzyme Induction; Female; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Phenylbutazone; Proadifen; Rats; Sleep | 1975 |
Hepatic drug metabolism after phenobarbital and diphenylhydantoin administration in the rat--influence of vitamin D3 status.
Topics: Animals; Calcium; Cholecalciferol; Hexobarbital; Liver; Male; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Phosphorus; Rats; Sleep; Time Factors; Vitamin D Deficiency | 1979 |
Interaction between microsomal electron transfer pathways.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Cytochrome Reductases; Cytochromes; Electron Transport; Ethylmorphine-N-Demethylase; Fatty Acids; Hexobarbital; Lipid Metabolism; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Peroxidases; Phenobarbital; Rats; Spectrum Analysis; Stearoyl-CoA Desaturase | 1975 |
Induction of hepatic mono-oxygenase systems of pregnant rats with phenobarbital and 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Binding Sites; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Female; Hemeproteins; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitriles; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnancy; Progesterone; Rats | 1977 |
Effect of roseoflavin on microsomal drug-metabolizing enzyme system.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Female; Flavins; Hexobarbital; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Riboflavin; Sleep; Sugar Alcohols | 1979 |
[Studies on drug metabolism in obese men and mice (author's transl)].
Topics: Adolescent; Adult; Animals; Enzyme Induction; Fatty Liver; Female; Hexobarbital; Humans; Male; Mice; Mice, Obese; Microsomes, Liver; Middle Aged; Obesity; Phenobarbital | 1979 |
Dantrolene inhibition of the hepatic mixed function oxidase system.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Dantrolene; Ethylmorphine-N-Demethylase; Hexobarbital; Hydantoins; Kinetics; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1979 |
Effect of phenobarbital and hexobarbital treatment on Lepidocephalichthys thermalis, a fresh water fish.
Topics: Acetylcholinesterase; Animals; Brain; Fishes; Hexobarbital; Lipase; Lipid Metabolism; Liver; Liver Glycogen; Oxygen Consumption; Phenobarbital; Proteins | 1979 |
Additional induction of microsomal cytochrome(s) P 450 in mouse liver by consecutive application of cadmium chloride and phenobarbital.
Topics: Animals; Benzopyrene Hydroxylase; Biphenyl Compounds; Cadmium; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hexobarbital; Hypnotics and Sedatives; Male; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Proteins | 1979 |
Inhibition of mono-oxygenase activities by 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydrase, in rat liver microsomes.
Topics: Aniline Compounds; Animals; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Hexobarbital; Hydrocarbons, Chlorinated; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1979 |
Pharmacokinetic and pharmacodynamic tolerance of a new anticonvulsant agent (3-sulfamoylmethyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin and carbamazepine in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Hexobarbital; Isoxazoles; Kinetics; Male; Oxazoles; Phenobarbital; Phenytoin; Proadifen; Rats; Sleep; Time Factors | 1979 |
Alternative transport pathways of cholephilic 14C-hexobarbital metabolites in rats with experimental hepatitis and cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile; Cholestasis; Chromatography, Thin Layer; Galactosamine; Hepatitis, Animal; Hexobarbital; Liver Function Tests; Male; Phenobarbital; Rats | 1979 |
Special experiments on central nervous effects of amitriptylinoxide considering pharmacokinetic aspects.
Topics: Administration, Oral; Amitriptyline; Animals; Anticonvulsants; Catalepsy; Central Nervous System; Diazepam; Electroshock; Hexobarbital; Humans; Injections, Intravenous; Kinetics; Male; Mice; Phenobarbital; Rats; Sleep; Tetrabenazine | 1978 |
Glutathione efflux from perfused rat liver after phenobarbital treatment, during drug oxidations, and in selenium deficiency.
Topics: Aminopyrine; Animals; Dose-Response Relationship, Drug; Ethylmorphine; Glutathione; Hexobarbital; L-Lactate Dehydrogenase; Liver; Male; Oxidation-Reduction; Perfusion; Phenobarbital; Rats; Selenium | 1978 |
The effect of prolonged sodium phenobarbitone treatment on hepatic xenobiotic metabolism and the urinary excretion of metabolites of the D-glucuronic acid pathway in the rat.
Topics: Animals; Diet; Glucuronates; Hexobarbital; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Sleep; Time Factors | 1978 |
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Paralysis; Phenobarbital; Rats; Sleep; Zoxazolamine | 1978 |
Microsomal mixed-function oxidase activity and senescence-I. Hexobarbital sleep time and induction of components of the hepatic microsomal enzyme system in rats of different ages.
Topics: Age Factors; Aging; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Sleep; Spectrum Analysis; Time Factors; Zoxazolamine | 1975 |
The toxicity of endrin and the effect of pretreatment of phenobarbital and hexobarbital on mortality in four fresh water fishes.
Topics: Animals; Endrin; Female; Fishes; Hexobarbital; Male; Phenobarbital; Time Factors | 1977 |
[Hexobarbital-oxidation in vivo and in vitro in rats after phenobarbital-pretreatment or after portacaval anastomosis (author's transl)].
Topics: Animals; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Portacaval Shunt, Surgical; Postoperative Complications; Rats | 1977 |
Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine.
Topics: Animals; Digitoxin; Drug Interactions; Ethionine; Female; Hexobarbital; In Vitro Techniques; Liver; Microscopy, Electron; Paralysis; Pharmaceutical Preparations; Phenobarbital; Pregnenolone Carbonitrile; Rats; Seizures; Sleep; Zoxazolamine | 1977 |
Temporal pattern and reversal of impaired hepatic mono-oxygenases by phenobarbital in rats with developing and established adjuvant disease.
Topics: Animals; Arthritis; Arthritis, Experimental; Cytochromes; Hexobarbital; Male; Microsomes, Liver; Oxygenases; Paralysis; Phenobarbital; Rats; Sleep; Time Factors; Zoxazolamine | 1977 |
Inhibition of hepatic microsomal enzymes by chloramphenicol.
Topics: Animals; Benzphetamine; Chloramphenicol; Cytochrome P-450 Enzyme System; Drug Interactions; Ethylmorphine-N-Demethylase; Hexobarbital; In Vitro Techniques; Male; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pentobarbital; Phenobarbital | 1977 |
Effect of 7 8-benzoflavone on the duration of zoxazolamine paralysis and hexobarbital hypnosis in rats.
Topics: Animals; Depression, Chemical; Flavonoids; Hexobarbital; Male; Methylcholanthrene; Paralysis; Phenobarbital; Rats; Sleep; Time Factors; Zoxazolamine | 1976 |
Phenobarbital as a hypocholesterolemic agent in the rat and rabbit.
Topics: Animals; Anticholesteremic Agents; Barbital; Bile; Bile Acids and Salts; Cholesterol; Hexobarbital; Hypercholesterolemia; Intestinal Absorption; Male; Phenobarbital; Rabbits; Rats | 1976 |
Hexobarbital sleeping time and drug metabolism in rats with ligated bile ducts--a lack of correlation.
Topics: Animals; Bile Ducts; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Proadifen; Protein Binding; Rats; Sleep; Thiopental; Time Factors; Zoxazolamine | 1976 |
[Interaction of psychotropic and anticonvulsive drugs].
Topics: Aminopyrine; Animals; Chlordiazepoxide; Chlorpromazine; Cytochrome P-450 Enzyme System; DNA; Hexobarbital; Imipramine; Liver; Male; Microsomes, Liver; Phenobarbital; Proteins; Rats; RNA | 1976 |
[Quantitative spectrophotometric determination of pheno and hexobarbital in small samples of blood].
Topics: Animals; Hexobarbital; Humans; Infant, Newborn; Phenobarbital; Spectrophotometry, Ultraviolet | 1976 |
The binding of hexobarbital and aniline to cytochrome P-450 of liver microsomes from control and phenobarbital-treated rats of different ages.
Topics: Aniline Compounds; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Hexobarbital; Male; Microsomes, Liver; Phenobarbital; Rats | 1976 |
Diethylnitrosamine-induced changes in mouse liver morphology and function.
Topics: Animals; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Hexobarbital; Liver; Liver Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Time Factors | 1976 |
Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes.
Topics: Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Glucaric Acid; Hexobarbital; In Vitro Techniques; Kinetics; Male; Mephenytoin; Microsomes, Liver; Phenobarbital; Phenylbutyrates; Phenytoin; Rats; Receptors, Drug; Urea | 1976 |
The effect of caffeine on barbiturate sleeping time and brain level.
Topics: Aminopyrine N-Demethylase; Analysis of Variance; Animals; Barbiturates; Brain Chemistry; Caffeine; Drug Interactions; Hexobarbital; Liver; Male; Morphine Derivatives; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Sleep; Time Factors | 1975 |
Influence of ibuprofen on drug-metabolizing enzymes in rat liver in vivo and in vitro.
Topics: Aminopyrine N-Demethylase; Animals; Ascorbic Acid; Drug Synergism; Hexobarbital; Ibuprofen; Kinetics; Liver; Male; Pharmaceutical Preparations; Phenobarbital; Propionates; Rats; Sleep; Time Factors | 1975 |
Effect of repeated exposure to aniline, nitrobenzene, and benzene on liver microsomal metabolism in the rat.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzene; Depression, Chemical; Fever; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Nitrobenzenes; Oxidoreductases; Phenacetin; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical | 1975 |
Stimulation of choline incorporation into a membrane fraction of rat liver by barbitals in vitro.
Topics: Animals; Cell Fractionation; Choline; Chromatography, Gel; Cytosol; Hexobarbital; Liver; Membranes; Methylcholanthrene; Phenobarbital; Rats; Time Factors | 1975 |
Age differences affecting induction of hepatic drug metabolizing enzymes by methaqualone and phenobarbital in the rat.
Topics: Age Factors; Animals; Enzyme Induction; Hexobarbital; Liver; Male; Methaqualone; Organ Size; Phenobarbital; Rats; Sleep; Time Factors | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors | 1975 |
Inhibition of drug metabolizing enzymes by diazepam in rat liver.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Depression, Chemical; Diazepam; Hexobarbital; Male; Microsomes, Liver; Nitrobenzoates; Phenobarbital; Rats | 1975 |
Drug metabolizing function of isolated perfused liver.
Topics: Animals; Bile; Ethionine; Hexobarbital; Indocyanine Green; Liver; Male; Nitrophenols; Perfusion; Phenobarbital; Rats; Sulfobromophthalein | 1975 |
Energy wastage in rats given drugs that induce microsomal enzymes.
Topics: Aminopyrine; Animals; Barbiturates; Body Weight; Energy Metabolism; Enzyme Induction; Ethanol; Female; Hexobarbital; Male; Microsomes, Liver; Oxygen Consumption; Phenobarbital; Rats | 1975 |
Biochemical aspects of the protective action of propyl gallate on liver injury in rats poisoned with carbon tetrachloride.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Acids, Nonesterified; Gallic Acid; Hexobarbital; Isocitrate Dehydrogenase; Lipid Metabolism; Male; Palmitic Acids; Peroxides; Phenobarbital; Propyl Gallate; Rats; Sleep; Time Factors; Triglycerides | 1975 |
Thin-layer chromatographic determination of barbiturates and phenytoin in serum and blood.
Topics: Animals; Barbiturates; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Hexobarbital; Humans; Kinetics; Phenobarbital; Phenytoin; Rats | 1975 |
Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Enzyme Induction; Hexobarbital; Hypoprothrombinemias; Liver; Male; Methaqualone; Phenobarbital; Proadifen; Prothrombin Time; Rats; Sleep; Time Factors; Warfarin | 1976 |
Prevention and reversal of tolerance to barbiturates by intraventricular injection of hemicholinium-3.
Topics: Animals; Barbiturates; Drug Tolerance; Hemicholinium 3; Hexobarbital; Injections, Intraventricular; Liver; Male; Orientation; Oxidoreductases, O-Demethylating; Phenobarbital; Rats; Reflex; Time Factors | 1976 |
Effect of nifedipine on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Hexobarbital; Liver; Male; Mixed Function Oxygenases; Nifedipine; Phenobarbital; Rats; Rats, Inbred Strains; Sleep | 1991 |
The effect of phenobarbital on the impairment of drug metabolism by carrageenan-induced inflammation in male rat.
Topics: Animals; Carrageenan; Cytochrome P-450 Enzyme System; Hexobarbital; Inflammation; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
A simple and rapid high-pressure liquid chromatographic assay for pentobarbital and other barbiturates in serum.
Topics: Animals; Barbiturates; Chromatography, High Pressure Liquid; Hexobarbital; In Vitro Techniques; Pentobarbital; Phenobarbital; Rabbits | 1988 |
Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates.
Topics: 7-Alkoxycoumarin O-Dealkylase; Amobarbital; Animals; Barbital; Barbiturates; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Hexobarbital; Isoenzymes; Liver; Liver Neoplasms; Male; Organ Size; Oxidoreductases; Oxygenases; Pentobarbital; Phenobarbital; Rats; Rats, Inbred F344 | 1987 |
Circadian rhythm of the liver of male rats pre-treated with phenobarbital--II. Hexobarbital sleeping time and lipids content in liver and serum.
Topics: Animals; Cholesterol; Circadian Rhythm; Hexobarbital; Lipid Metabolism; Lipids; Lipoproteins, LDL; Liver; Male; Phenobarbital; Phospholipids; Rats; Rats, Inbred Strains; Reference Values; Sleep; Triglycerides | 1987 |
Correlation of apparent intrinsic clearances of simultaneously administered S (+) and d3R (-) hexobarbital in the rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Male; Metabolic Clearance Rate; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1987 |
Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats.
Topics: Administration, Oral; Aminopyrine; Animals; Aroclors; Carbon Tetrachloride; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hexobarbital; Isoenzymes; Liver; Male; Metabolic Clearance Rate; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Interrelationship between aminopyrine oxidation and gluconeogenesis in hepatocytes prepared from fructose-pretreated mice.
Topics: Aminopyrine; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Formaldehyde; Fructose; Gluconeogenesis; Hexobarbital; Kinetics; Liver; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oxidation-Reduction; Phenobarbital | 1987 |
Biphasic effect of pyrazolone derivatives on drug-metabolizing enzyme in rat liver.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Dealkylation; Female; Hexobarbital; Liver; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Time Factors | 1985 |
[Metabolic interactions of denaverine].
Topics: Animals; Benzilates; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hexobarbital; Liver; Microsomes, Liver; Models, Biological; NADPH-Ferrihemoprotein Reductase; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Sleep | 1985 |
Enzyme induction in sheep: effects of phenobarbital on in vivo and in vitro drug metabolism.
Topics: Anesthesia; Aniline Compounds; Animals; Antipyrine; Cytochromes; Dicumarol; Enzyme Induction; Female; Formaldehyde; Half-Life; Hexobarbital; Metabolic Clearance Rate; Microsomes, Liver; Pentobarbital; Phenobarbital; Phenols; Proteins; Sheep; Sleep; Sulfobromophthalein; Time Factors | 1972 |
Microsomal phospholipids and drug action--quantitative biochemical and electron microscopic studies.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Dactinomycin; Endoplasmic Reticulum; Ethanol; Ethionine; Female; Glucose-6-Phosphatase; Hexobarbital; Histocytochemistry; In Vitro Techniques; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Nitrosamines; Phenobarbital; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats | 1972 |
Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Hydroxylation; Kidney; Methylcholanthrene; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred NZB; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polycyclic Compounds; Protein Binding; Pyridines; Spectrophotometry | 1972 |
[Circadian variations in barbiturate response in rats (author's transl)].
Topics: Animals; Circadian Rhythm; Hexobarbital; Lethal Dose 50; Liver; Male; Phenobarbital; Rats; Sleep | 1972 |
Kinetics of CO and O 2 complexes of rabbit liver microsomal cytochrome P 450 .
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hexobarbital; In Vitro Techniques; Kinetics; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Photolysis; Protein Binding; Rabbits; Time Factors | 1973 |
Oxidation of barbiturates and the glucuronidation of 1-napthol in perfused rat liver and in microsomes.
Topics: Animals; Barbiturates; Biotransformation; Carbon Radioisotopes; Glucuronates; Half-Life; Hexobarbital; Hexosyltransferases; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; NADP; Naphthols; Oxidation-Reduction; Perfusion; Phenobarbital; Rats | 1974 |
The effect of barbiturates on (3H)GABA transport in rat cerebral cortex slices.
Topics: Aminobutyrates; Amobarbital; Animals; Binding, Competitive; Biological Transport; Cell Membrane; Cerebral Cortex; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Hexobarbital; Male; Ouabain; Pentobarbital; Phenobarbital; Potassium; Rats; Sodium; Stimulation, Chemical; Time Factors; Tritium | 1974 |
Drugs, alcohol and sex hormones: a molecular perspective of the receptivity of cytochrome P-450.
Topics: Adrenal Glands; Animals; Barbiturates; Binding, Competitive; Cattle; Cytochrome P-450 Enzyme System; Electron Transport; Estradiol; Ethanol; Gonadal Steroid Hormones; Hexobarbital; Microsomes; Microsomes, Liver; Mitochondria; Morphine Derivatives; NAD; NADP; Oxidation-Reduction; Phenobarbital; Testosterone | 1973 |
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action.
Topics: Aniline Compounds; Animals; Antipyrine; Benzopyrenes; Cytochromes; Dicumarol; Electron Transport; Enzyme Induction; Hexobarbital; Kinetics; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Protein Binding; Prothrombin Time | 1968 |
Action of drugs on the electrical activity of the red nucleus.
Topics: Animals; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Diazepam; Electrodes; Electrophysiology; Ethanol; Hexobarbital; Hippocampus; Male; Mephenesin; Meprobamate; Oxazepam; Pentobarbital; Phenobarbital; Rabbits; Red Nucleus; Thiopental; Urethane | 1969 |
[Influence of amphetamine and phenobarbital treatment on hexobarbital narcosis].
Topics: Amphetamine; Anesthesia; Animals; Drug Synergism; Female; Hexobarbital; Phenobarbital; Rats | 1967 |
[Stimulation of drug oxidation in kidney microsomes by phenobarbital].
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochromes; DDT; Hexobarbital; Kidney; Liver; Male; Microsomes; Organ Size; Phenobarbital; Rabbits; Rats; Stimulation, Chemical | 1968 |
[Spectral properties of cytochrome P450 following induction with phenobarbital, benzopyrene and methylcholanthrene].
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochromes; Enzyme Induction; Hexobarbital; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Spectrophotometry; Stimulation, Chemical | 1968 |
Studies on the nature of the type I and type II spectral changes in liver microsomes.
Topics: Aniline Compounds; Animals; Benzopyrenes; Binding Sites; Cytochromes; Heme; Hexobarbital; Male; Microsomes, Liver; Niacinamide; Phenobarbital; Proteins; Rats; Spectrophotometry; Ultraviolet Rays | 1970 |
Drug metabolism by hepatic microsomes from phenobarbital-treated or starved male and female rats in the presence of inhibitors.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Female; Hexobarbital; Liver; Male; Methylation; Microsomes, Liver; Morphinans; Niacinamide; Organ Size; Phenobarbital; Proadifen; Rats; Starvation | 1971 |
Decreased effect of phenobarbital treatment on microsomal drug metabolizing enzyme activity during gestation.
Topics: Animals; Benzopyrenes; Body Weight; Cytochrome P-450 Enzyme System; Dealkylation; Depression, Chemical; Female; Fetus; Hexobarbital; Hydroxylation; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Organ Size; Phenobarbital; Pregnancy; Pregnancy, Animal; Proteins; Rats; Sleep; Time Factors; Uterus | 1974 |
Proceedings: Kinetics of the binding of carbon monoxide and oxygen to microsomal cytochrome P450 and the influence of substrates.
Topics: Animals; Binding Sites; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Halothane; Hexobarbital; In Vitro Techniques; Kinetics; Ligands; Metyrapone; Microsomes, Liver; Oxygen Consumption; Phenobarbital; Photolysis; Rats; Spectrophotometry; Temperature; Tetrachloroethylene; Trichloroethylene | 1974 |
Varying effect of phenobarbital on hepatic drug metabolism in rats of different ages.
Topics: Age Factors; Animals; Animals, Newborn; Benzopyrenes; Enzyme Induction; Female; Fetus; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphine; Organ Size; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1974 |
Stress stimulation of drug metabolism in the rat.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Corticosterone; Dactinomycin; Hexobarbital; Hypophysectomy; In Vitro Techniques; Meprobamate; Pentobarbital; Phenobarbital; Pituitary Gland; Pituitary-Adrenal System; Rats; Stress, Physiological | 1966 |
The effect of phenobarbital on drug metabolic enzyme activity, ultrastructure and growth of a "minimal deviation" hepatoma (Morris 7800).
Topics: Animals; Carcinoma, Hepatocellular; Endoplasmic Reticulum; Hexobarbital; Liver; Liver Neoplasms; Male; Microscopy, Electron; Neoplasms, Experimental; Phenobarbital; Rats | 1967 |
Effect of starvation on the in vivo metabolism and effect of drugs in female and male rats.
Topics: Amides; Anesthesia; Animals; Barbiturates; Body Weight; Carisoprodol; Diphosphates; Female; Hexobarbital; Kidney; Liver; Male; Organ Size; Paralysis; Pentobarbital; Phenobarbital; Rats; Starvation; Strychnine; Sucrose; Zoxazolamine | 1967 |
Further observations on hepatic drug metabolism in rats treated with a mixture of somatotropin, corticotropin and prolactin.
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Growth Hormone; Hexobarbital; Liver; Male; Microsomes, Liver; Morphinans; Neoplasm Transplantation; Phenobarbital; Pituitary Neoplasms; Prolactin; Rats | 1969 |
Antagonistic effect of foreign compounds on microsomal enzymes of the liver of the rat.
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Coumarins; Drug Antagonism; Enzymes; Ethionine; Female; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Phosphoric Monoester Hydrolases; Rats; Toluene | 1970 |
[Influencing of microsomal enzymes by carbon tetrachloride with and without phenobarbital pretreatment].
Topics: Aniline Compounds; Animals; Carbon Tetrachloride Poisoning; Cytochromes; Furaldehyde; Glucose-6-Phosphatase; Hexobarbital; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Phenols; Rats | 1971 |
[Effect of carbon tetrachloride on endoplasmic enzymes in rat liver].
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cholinesterases; Cytochromes; Endoplasmic Reticulum; Formaldehyde; Glucose-6-Phosphatase; Hexobarbital; Male; Membranes; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrophotometry | 1971 |
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Cortisone; Cytochrome c Group; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Female; Guinea Pigs; Hexobarbital; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Oxidoreductases; Pentylenetetrazole; Pharmaceutical Preparations; Phenobarbital; Rats; Research; Sleep; Spironolactone | 1972 |
The incomplete conversion of hepatic cytochrome P-450 to P-420 by mercurials.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Electron Spin Resonance Spectroscopy; Hexobarbital; Hydrogen-Ion Concentration; Hydrolysis; Liver; Mercury; Microsomes, Liver; Morphinans; Niacinamide; Organomercury Compounds; Organometallic Compounds; Phenobarbital; Proteins; Rats; Spectrophotometry; Spectrum Analysis; Trypsin | 1972 |
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Enzyme Induction; Female; Hexobarbital; Liver; Microscopy, Electron; Microsomes, Liver; Morphinans; NAD; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; Serum Albumin, Bovine; Time Factors | 1974 |
Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.
Topics: Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chloromercuribenzoates; Drug Synergism; Hexobarbital; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NAD; Nitro Compounds; Oxidation-Reduction; Oxygen Consumption; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Phenols; Proadifen; Pyridines; Rats; Spectrophotometry | 1974 |
Possible role of P-450 in the oxidation of drugs in liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Carisoprodol; Chlorpromazine; Cytochromes; Glutethimide; Hexobarbital; In Vitro Techniques; Liver; Microsomes; Oxidoreductases; Pentobarbital; Phenobarbital; Piperazines; Rats | 1966 |
Influence of age and diet on the induction of hexobarbital-metabolizing enzymes in the mouse.
Topics: Age Factors; Animals; Animals, Newborn; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Diet; Enzyme Induction; Hexobarbital; Histamine H1 Antagonists; Liver; Male; Metronidazole; Mice; Microsomes; Oils; Phenobarbital; Piperazines; Sleep; Starvation; Zea mays | 1968 |
The effect of diphenyl-piperazine compounds and other agents on diphenylhydantoin, zoxazolamine and hexobarbital metabolism.
Topics: Animals; Benzopyrenes; Cyclizine; DDT; Diphenhydramine; Endoplasmic Reticulum; Hexobarbital; Humans; Hydroxyzine; Liver; Male; Meclizine; Methylcholanthrene; Mice; Microscopy, Electron; Phenethylamines; Phenobarbital; Phenytoin; Piperazines; Trifluoperazine; Zoxazolamine | 1968 |
Metabolism and cytochrome P-450 binding spectra of (+)- and (-)-hexobarbital in rat liver microsomes.
Topics: Animals; Cytochromes; Hexobarbital; Kinetics; Liver; Male; Microsomes; NADP; Phenobarbital; Rats; Spectrophotometry; Stereoisomerism | 1969 |
The inhibitory effect of aureomycin (chlortetracycline) pretreatment on some rat liver microsomal enzyme activities.
Topics: Albumins; Aminopyrine; Animals; Body Weight; Chlortetracycline; Cytochromes; Depression, Chemical; Hexobarbital; Injections, Intraperitoneal; Liver; Magnesium; Male; Microsomes; NADP; Organ Size; Phenobarbital; Proteins; Rats; Sleep | 1969 |
[A spray reagent combination for differential determination of methyprylon from its main metabolite methylpersedon as well as a selection of hypnotics and eukraton on thin layer chromatograms].
Topics: Barbiturates; Bemegride; Chromatography, Thin Layer; Glutethimide; Hexobarbital; Hypnotics and Sedatives; Indicators and Reagents; Methaqualone; Phenobarbital; Piperidines; Urea | 1969 |
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.
Topics: Aminopyrine; Animals; Appetite Depressants; Benzphetamine; Cytochromes; Depression, Chemical; Ethers; Fatty Acids; Formaldehyde; Hexobarbital; Lipid Metabolism; Liver; Microsomes; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenethylamines; Phenobarbital; Propylamines; Rabbits; Spectrophotometry | 1969 |
Effects of metyrapone on liver microsomal drug oxidations.
Topics: Acetanilides; Aminopyrine; Animals; Depression, Chemical; Hexobarbital; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Morphine; NADP; Phenobarbital; Rats; Sleep; Stimulation, Chemical; Trichloroethylene; Tyramine | 1969 |
Hepatic drug-metabolizing enzyme activity in rats pretreated with (-)-emetine or (plus or minus)-2,3-dehydroemetine.
Topics: Aminopyrine; Animals; Depression, Chemical; Drug Synergism; Emetine; Female; Glucosephosphate Dehydrogenase; Hexobarbital; Liver; Microsomes, Liver; NADP; Phenobarbital; Rats; Sulfonamides | 1970 |
Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat.
Topics: Animals; Benzoates; Cyclophosphamide; Cytochromes; Female; Glucose-6-Phosphatase; Hexobarbital; Hydrocortisone; Male; Microsomes, Liver; NADP; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Sex Factors; Testosterone | 1970 |
Interaction of mixed function oxidase with its substrates and associated redox transitions of cytochrome P-450 and pyridine nucleotides in perfused rat liver.
Topics: Animals; Cytochromes; Endoplasmic Reticulum; Fluorescence; Hexobarbital; Lactates; Liver; Male; Metyrapone; Microsomes, Liver; NAD; NADP; Oxidoreductases; Oxygen Consumption; Perfusion; Phenobarbital; Pyruvates; Rats; Spectrophotometry | 1970 |
Different effect of aflatoxin on the induction of tryptophan oxygenase and of microsomal drug-hydroxylase system.
Topics: Aflatoxins; Animals; Cytochromes; Enzyme Induction; Female; Hexobarbital; Hydrocortisone; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pigments, Biological; Rats; Tryptophan Oxygenase; Tyrosine Transaminase; Zoxazolamine | 1970 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitro.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Calcium; Chlorides; Cobalt; Copper; Cytochromes; Edetic Acid; Hexobarbital; In Vitro Techniques; Iron; Magnesium; Male; Manganese; Microsomes, Liver; NADP; Nitrophenols; Phenobarbital; Potassium; Rats; Strontium; Sulfates; Zinc; Zoxazolamine | 1970 |
Influence of age and diet on the induction of microsomal enzymes in the mouse.
Topics: Aging; Animals; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Cytochromes; Dietary Proteins; Enzyme Induction; Hexobarbital; Male; Mice; Microsomes, Liver; Phenobarbital; Piperazines; Protein Binding; Proteins; Spectrophotometry; Stimulation, Chemical; Ultracentrifugation | 1971 |
Relationship between difference spectra and metabolism. Barbiturates, drug interaction and species difference.
Topics: Acetanilides; Acetates; Amino Alcohols; Aminopyrine; Aniline Compounds; Animals; Barbiturates; Binding Sites; Chemical Phenomena; Chemistry; Chlorpromazine; Cytochromes; Drug Antagonism; Drug Synergism; Ethanolamines; Hexobarbital; Macaca; Male; Mice; Microsomes, Liver; Pentobarbital; Phenobarbital; Proadifen; Propranolol; Protein Binding; Rats; Sleep; Species Specificity; Spectrophotometry; Thiazoles; Tremorine | 1970 |
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea | 1970 |
The state of NADPH-NADP + during mixed-function oxidation of hexobarbital in hemoglobin-free perfused rat liver.
Topics: Animals; Fluorometry; Hemoglobins; Hexobarbital; Liver; Mitochondria, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Perfusion; Phenobarbital; Rats | 1971 |
The action of sympatholytic drugs in experimental intestinal paralysis.
Topics: Anesthesia; Animals; Cats; Chlorpromazine; Disease Models, Animal; Ganglionic Blockers; Gastrointestinal Motility; Hexobarbital; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Parasympathomimetics; Phenobarbital; Postoperative Complications; Sympathetic Nervous System; Sympatholytics; Tranquilizing Agents; Trifluperidol | 1971 |
A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase.
Topics: Amobarbital; Animals; Barbiturates; Cytochromes; Hexobarbital; Hydrogen-Ion Concentration; Lipids; Male; Microsomes, Liver; NAD; NADP; Oxygenases; Pentobarbital; Phenobarbital; Rats; Secobarbital; Solubility; Spectrophotometry | 1972 |
Interactions of digitoxigenin and digoxigenin with cytochrome P-450.
Topics: Animals; Cardanolides; Cytochrome c Group; Drug Interactions; Hexobarbital; In Vitro Techniques; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Testosterone | 1972 |
[Drug permeation through synthetic lipid membranes. Permeability of lecithin-collodium membranes for drugs and metabolites].
Topics: Buffers; Caffeine; Diffusion; Hexobarbital; Hydrogen-Ion Concentration; Kinetics; Membranes, Artificial; Models, Chemical; Papaverine; Phenobarbital; Phenytoin; Phosphatidylcholines; Quinine; Salicylates; Solutions; Time Factors | 1974 |
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione.
Topics: Acute Disease; Anesthesia, Inhalation; Aniline Compounds; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chloroform; Chromatography, Gas; Cytochrome Reductases; Enzyme Induction; Glutathione; Halothane; Hexobarbital; Liver; Male; Maleates; Microsomes, Liver; Phenobarbital; Rats | 1974 |
Has ricin an enzyme inductive effect?
Topics: Animals; Behavior, Animal; Biotransformation; Enzyme Induction; Female; Hexobarbital; Liver; Phenobarbital; Rats; Ricin; Sleep; Time Factors; Toxins, Biological | 1974 |
A study of the development of tolerance to an anticonvulsant effect of delta9-tetrahydrocannabinol and cannabidiol.
Topics: Animals; Anticonvulsants; Cannabis; Dronabinol; Drug Interactions; Drug Synergism; Drug Tolerance; Electroshock; Hexobarbital; Male; Mice; Mice, Inbred ICR; Phenobarbital; Phenytoin; Resorcinols; Sleep; Terpenes; Time Factors | 1974 |
[Intravenous load by pheno-and hexobarbital in mature and premature newborn infants and young infants].
Topics: Birth Weight; Body Water; Hexobarbital; Humans; Infant, Newborn; Infant, Premature; Injections, Intravenous; Phenobarbital | 1974 |
Modification of the effects of 9 -tetrahydrocannabinol by phenobarbital pretreatment in mice.
Topics: Animals; Anticonvulsants; Cannabis; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Electroshock; Hexobarbital; Hindlimb; Male; Mice; Phenobarbital; Sleep; Time Factors | 1972 |
A rapid micro-method for the screening and measurement of barbiturates and related compounds in plasma by gas-liquid chromatography.
Topics: Amobarbital; Animals; Barbiturates; Blood Specimen Collection; Cattle; Chromatography, Gas; Evaluation Studies as Topic; Glutethimide; Hexobarbital; Humans; Methaqualone; Methods; Microchemistry; Pentobarbital; Phenobarbital; Secobarbital; Time Factors | 1972 |
Partial purification and properties of cytochromes P-450 and P-448 from rat liver microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Carbon Isotopes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electrophoresis, Polyacrylamide Gel; Heme; Hexobarbital; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Phospholipids; Protein Binding; Rats; Sodium Dodecyl Sulfate; Solubility; Spectrophotometry; Spectrophotometry, Ultraviolet; Tritium | 1972 |
[Drug metabolism in experimental cholestasis].
Topics: Animals; Cholestasis; Hexobarbital; Phenobarbital; Rats | 1972 |
Effect of phenobarbital and 3,4-benzpyrene treatment of rats on the microsomal binding and hydroxylation of nortriptyline and desmethyl-imipramine: evidence for qualitative changes in cytochrome P-450-ligand interaction following phenobarbital pretreatmen
Topics: Animals; Benzopyrenes; Binding Sites; Chromatography, Gas; Cytochrome P-450 Enzyme System; Desipramine; Hexobarbital; Ligands; Male; Microsomes, Liver; Mixed Function Oxygenases; Nortriptyline; Phenobarbital; Protein Binding; Rats; Receptors, Drug; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1972 |
Effect of dietary lipid ingestion on the induction of drug-metabolizing enzymes by phenobarbital.
Topics: Aniline Compounds; Animals; Cocos; Dietary Fats; Enzyme Induction; Fatty Acids, Unsaturated; Hexobarbital; Kinetics; Liver; Male; Membranes; Microsomes, Liver; Oils; Organ Size; Phenobarbital; Phospholipids; Rats; Zea mays | 1973 |
Effect of suramin (Bayer 205) on hepatic microsomal cytochromes P-450, b 5 , and demethylation activity in rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Dealkylation; Drug Interactions; Hexobarbital; Liver; Microsomes, Liver; Morphinans; Organ Size; Phenobarbital; Rats; Suramin; Time Factors | 1973 |
Acute lethality for mice following administration of cyclophosphamide with barbiturates.
Topics: Aminopyrine; Animals; Cyclophosphamide; Drug Synergism; Hexobarbital; Lethal Dose 50; Liver; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mortality; Pentobarbital; Phenobarbital | 1973 |
A role of the dietary lipid in the ability of phenobarbital to stimulate drug detoxification.
Topics: Aminopyrine; Animals; Biotransformation; Chlorpromazine; Dietary Fats; Fatty Acids; Female; Glucosephosphate Dehydrogenase; Hexobarbital; In Vitro Techniques; Lipids; Liver; Mice; Mice, Inbred ICR; Microsomes, Liver; Phenobarbital; Rats; Sleep; Time Factors; Zoxazolamine | 1973 |
Modification of acrylamide neuropathy in rats by selected factors.
Topics: Acrylamides; Adrenal Glands; Adrenalectomy; Age Factors; Animals; DDT; Enzyme Induction; Hexobarbital; Hydrocortisone; In Vitro Techniques; Liver; Male; Microsomes, Liver; Motor Activity; Myelin Sheath; Neurons; Oxidoreductases; Peripheral Nerves; Phenobarbital; Proadifen; Rats; Thiamine Deficiency; Time Factors; Vitamin B 6 Deficiency | 1973 |
Interactions of the hexobarbital enantiomers with rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; Hemeproteins; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methyltransferases; Microsomes, Liver; Morphinans; Morphine; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1973 |
Influence of different types of narcosis and of neck fracture on the concentration of glycolytic intermediates and related compounds in rat liver.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Anesthetics; Animals; Citrates; Ethyl Ethers; Fractures, Bone; Glycerophosphates; Glycolysis; Halothane; Hexobarbital; Hexosephosphates; Lactates; Liver; Malates; Male; Neck; Oxaloacetates; Pentobarbital; Phenobarbital; Pyruvates; Rats; Time Factors; Urethane | 1973 |
Effects of dietary protein quality on drug metabolism in the rat.
Topics: Anesthesia; Aniline Compounds; Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Dealkylation; Dietary Proteins; Drug Synergism; Glutens; Hexobarbital; Hydroxylation; Liver; Male; Microsomes, Liver; Morphinans; Organ Size; Phenobarbital; Proadifen; Proteins; Rats; Time Factors | 1973 |
Effect of benzene on hepatic drug metabolism and ultrastructure.
Topics: Animals; Azo Compounds; Benzene; Benzene Derivatives; Benzoates; Body Weight; Carbon Radioisotopes; Endoplasmic Reticulum; Hexobarbital; Liver; Male; Microscopy, Electron; Microsomes, Liver; Naphthalenesulfonates; Nitro Compounds; Organ Size; Phenobarbital; Rats; Time Factors; Zoxazolamine | 1973 |
Spectroscopic evidence of interaction between 2-allyl-2-isopropylacetamide and cytochrome P-450 of rat liver microsomes.
Topics: Acetamides; Allylisopropylacetamide; Animals; Binding Sites; Computers, Analog; Cytochrome P-450 Enzyme System; Hexobarbital; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Regression Analysis; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
Effect of dibromotetrafluoroethane inhalation on hepatic drug metabolism in mice.
Topics: Animals; Chlorofluorocarbons, Methane; Drug Interactions; Hexobarbital; Hydrocarbons, Halogenated; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Paralysis; Phenobarbital; Proadifen; Respiration; Sleep; Time Factors; Zoxazolamine | 1973 |
Comparison of phenobarbital with orphenadrine hydrochloride and tofenacine hydrochloride for enzyme-inducing activity in young and adult rats.
Topics: Aging; Animals; Benzene Derivatives; Body Weight; Drug Tolerance; Enzyme Induction; Ethers; Ethylamines; Hexobarbital; Liver; Male; Motor Activity; Orphenadrine; Phenobarbital; Rats; Sleep; Time Factors | 1973 |
Effect of physicochemical and pharmacokinetic properties of barbiturates on the induction of drug metabolism.
Topics: Amobarbital; Aniline Compounds; Animals; Barbiturates; Cytochrome P-450 Enzyme System; Enzyme Induction; Half-Life; Hexobarbital; Kinetics; Lipids; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phenobarbital; Proteins; Rats; Secobarbital; Solubility | 1973 |
Stimulation of liver detoxication enzymes by dietary cadmium acetate.
Topics: Acetates; Animals; Cadmium; Diet; Dose-Response Relationship, Drug; Drug Interactions; Female; Hexobarbital; Methyltransferases; Microsomes, Liver; Phenobarbital; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Rats; Sleep; Stimulation, Chemical; Time Factors | 1973 |
[Relations between drug metabolizing liver enzyme system activity and disease course of experimental hepatic coma in animal experiment].
Topics: Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Hepatic Encephalopathy; Hexobarbital; Liver; Phenobarbital | 1973 |
Spectral studies on drug-cytochrome P-450 interaction in isolated rat liver cells.
Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Hexobarbital; Humans; Kinetics; Lidocaine; Liver; Male; Nortriptyline; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Substance-Related Disorders; Time Factors | 1973 |
[Studies in mice on the effectiveness of various methods of enzyme induction with phenobarbital].
Topics: Administration, Oral; Animals; Body Weight; Dose-Response Relationship, Drug; Enzyme Induction; Female; Hexobarbital; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Mice; Mice, Inbred Strains; Microsomes, Liver; Organ Size; Phenobarbital; Sleep; Time Factors | 1973 |
The metabolic fate of hexobarbital in the rat.
Topics: Animals; Bile; Carbon Radioisotopes; Countercurrent Distribution; Feces; Half-Life; Hexobarbital; Hydroxylation; In Vitro Techniques; Ketones; Kidney; Kinetics; Liver; Male; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry, Ultraviolet; Time Factors; Urea | 1974 |
New approach to derivatization and gas-chromatographic analysis of barbiturates.
Topics: Amobarbital; Barbiturates; Chromatography, Gas; Evaluation Studies as Topic; Hexobarbital; Humans; Mephobarbital; Methods; Pentobarbital; Phenobarbital; Secobarbital | 1974 |
Effect of barbiturates on the liver of rats exposed to carbon disulphide vapour.
Topics: Animals; Barbiturates; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Environmental Exposure; Fatty Liver; Female; Hexobarbital; Humans; Liver; Occupational Medicine; Phenobarbital; Rats | 1974 |
The effect of short- and long-acting barbiturates on the oxygen uptake of the intact lens and its homogenate.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Hexobarbital; In Vitro Techniques; Lens, Crystalline; Oxygen Consumption; Phenobarbital; Rabbits | 1974 |
Propylene glycol as a drug solvent in the study of hepatic microsomal enzyme metabolism in the rat.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Benzoates; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dealkylation; Dose-Response Relationship, Drug; Hexobarbital; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nitro Compounds; Pharmaceutical Preparations; Phenobarbital; Propylene Glycols; Rats; Sleep; Solvents; Time Factors | 1974 |
The effect of pretreatment with dieldrin on certain in vivo parameters of enzyme induction in mice.
Topics: Animals; Barbiturates; Brain Chemistry; Cytochrome P-450 Enzyme System; Dieldrin; Enzyme Induction; Hexobarbital; Lethal Dose 50; Male; Mice; Microsomes, Liver; Pentobarbital; Phenobarbital; Sleep; Thiopental; Time Factors | 1974 |
Some in vitro assay conditions that affect detection and quantitation of phenobarbital-induced increases in hepatic microsomal drug-metabolizing enzyme activity.
Topics: Air; Aminopyrine; Aniline Compounds; Animals; Buffers; Enzyme Induction; Glass; Hexobarbital; Histological Techniques; In Vitro Techniques; Male; Medical Laboratory Science; Microsomes, Liver; Oxygen; Phenobarbital; Phosphates; Proteins; Rats; Sleep; Time Factors | 1970 |
Apparent enzyme inhibition through enzyme-induction studies as a possible mode of action of certain cobalt compounds.
Topics: Animals; Chlorides; Cobalt; Enzyme Induction; Enzyme Inhibitors; Female; Hexobarbital; Mice; Nitrites; Phenobarbital; Sleep; Zoxazolamine | 1971 |
Diurnal rhythm in endoplasmic reticulum of rat liver: electron microscopic study.
Topics: Animals; Blindness; Cell Nucleus; Circadian Rhythm; Endoplasmic Reticulum; Golgi Apparatus; Hexobarbital; Liver; Male; Microscopy, Electron; Mitochondria, Liver; Oxidoreductases; Phenobarbital; Rats | 1972 |
Amphetamine aggregation effect in mice under conditions of altered microsomal enzymes.
Topics: Amphetamine; Animals; Behavior, Animal; Chlordan; Crowding; Drug Synergism; Enzyme Induction; Hexobarbital; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Microsomes; Phenobarbital; Proadifen; Sleep; Social Isolation | 1972 |
Spectral studies of the binding of O,O-diethyl p-nitrophenylphosphorothionate (parathion) to cytochrome P-450.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Binding Sites; Cytochromes; Hexobarbital; Male; Microsomes, Liver; Morphinans; Parathion; Phenobarbital; Protein Binding; Rabbits; Spectrophotometry | 1972 |
The effect of experimental local inflammation on the action of barbiturates in rat.
Topics: Animals; Barbiturates; Carbon Tetrachloride; Carrageenan; Charcoal; Chlordan; Enzyme Induction; Gossypium; Hexobarbital; Inflammation; Injections, Subcutaneous; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sleep; Time Factors; Yeasts | 1972 |
A new technique for solid injection in gas-liquid chromatography. Analysis of barbiturates in urine.
Topics: Barbiturates; Chromatography, Gas; Ethers; Hexobarbital; Humans; Methods; Microchemistry; Pentobarbital; Phenobarbital | 1972 |
A possible role for the mixed function oxidase enzyme system in the requirement for selenium in the rat.
Topics: Aminopyrine; Animals; Body Weight; Castration; Deficiency Diseases; Estradiol; Female; Feminization; Hexobarbital; Male; Microsomes, Liver; Nutritional Requirements; Oxidoreductases; Phenobarbital; Rats; Selenium; Sex Factors; Testosterone | 1972 |
A molecular orbital study of the conformation of barbiturates.
Topics: Amobarbital; Barbiturates; Electrons; Hexobarbital; Models, Structural; Phenobarbital; Quantum Theory; Structure-Activity Relationship; X-Ray Diffraction | 1972 |
[Participation of liver microsome enzyme systems in the metabolism of penicillin].
Topics: Animals; Biotransformation; Hexobarbital; Iproniazid; Microsomes, Liver; Muscles; Penicillins; Phenobarbital; Rabbits; Rats | 1972 |
Effects of ascorbic acid deficiency on kinetics of drug hydroxylation in male guinea pigs.
Topics: Aniline Compounds; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Cytochromes; Guinea Pigs; Hexobarbital; Hydroxylation; Kinetics; Liver; Male; Microsomes, Liver; Morphinans; Organ Size; Pharmaceutical Preparations; Phenobarbital; Proteins; Time Factors | 1972 |
Microsomal drug-metabolizing enzymes activity and induction in the rat liver after portacaval shunt.
Topics: Animals; Body Weight; Enzyme Induction; Hexobarbital; Male; Microsomes, Liver; Organ Size; Phenobarbital; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Strychnine; Time Factors | 1972 |
5,5'-Diphenyl-2-thiohydantoin (DPTH): an inducer of microsomal drug-metabolizing enzymes.
Topics: Animals; Cytochromes; Electron Transport; Endoplasmic Reticulum; Enzyme Induction; Hexobarbital; Liver; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Microsomes, Liver; Organ Size; Phenobarbital; Phenytoin; Proteins; Rats; Rats, Inbred Strains; Sleep; Sulfides; Time Factors | 1972 |
Effects of phenobarbital pretreatment on rat pancreas.
Topics: Amylases; Animals; Atropine; Carbon Isotopes; Enzyme Induction; Female; Hexobarbital; In Vitro Techniques; Leucine; Lipase; Microsomes; Mixed Function Oxygenases; Morphinans; Organ Size; Oxidoreductases; Pancreas; Phenobarbital; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains; Ribonucleases; Zoxazolamine | 1972 |
Simultaneous identification and quantitation of submicrogram amounts of barbiturates by gas chromatography.
Topics: Barbiturates; Chromatography, Gas; Hexobarbital; Methaqualone; Methods; Methohexital; Pentobarbital; Phenobarbital; Thiamylal; Thiopental | 1972 |
[Synthesis of optically active N-methylbarbiturates. 12. Barbituric acid derivatives].
Topics: Acetates; Barbiturates; Codeine; Cyanides; Hexobarbital; Methylation; Optical Rotation; Phenobarbital; Quinine | 1972 |
Influence of phenobarbital on the metabolism and analgesic effect of methadone in rats.
Topics: Analgesia; Animals; Biotransformation; Estradiol; Hexobarbital; Hydrocarbons; Kinetics; Male; Methadone; Microsomes, Liver; Morphinans; Phenobarbital; Rats; Testosterone | 1972 |
Ethanol tolerance and ethanol-drug interactions in the rat.
Topics: Animals; Barbiturates; Behavior, Animal; Body Weight; Depression, Chemical; Drug Interactions; Drug Tolerance; Ethanol; Female; Hexobarbital; Injections, Intraperitoneal; Male; Meprobamate; Motor Activity; Organ Size; Pentobarbital; Phenobarbital; Rats; Rats, Inbred Strains; Zoxazolamine | 1972 |
A gas-chromatographic method for separating and measuring barbiturates and glutethimide in blood.
Topics: Amobarbital; Barbiturates; Blood Chemical Analysis; Chloroform; Chromatography, Gas; Evaluation Studies as Topic; Glass; Glutethimide; Hexobarbital; Humans; Hydrogen-Ion Concentration; Mathematics; Mephobarbital; Methods; Methohexital; Methylation; Pentobarbital; Phenobarbital; Secobarbital; Solubility; Spectrophotometry; Time Factors; Ultraviolet Rays | 1971 |
[Stimulation and inhibition of hexobarbital metabolism by previous administration of phenobarbital and nikethamide].
Topics: Animals; Biotransformation; Depression, Chemical; Drug Interactions; Enzyme Induction; Hexobarbital; Liver; Male; Mice; Nikethamide; Phenobarbital | 1971 |
[Changes of drug effects caused by their metabolism in the liver].
Topics: Aminopyrine; Animals; Cytochromes; Dogs; Drug Stability; Endoplasmic Reticulum; Female; Fetus; Hexobarbital; Humans; Liver; Male; Metabolism; Mice; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Pregnancy; Rabbits; Rats; Thiopental | 1971 |
Kinetic differences in the microsomal metabolism of the isomers of hexobarbital.
Topics: Animals; Enzyme Induction; Hexobarbital; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rabbits; Rats; Stereoisomerism; Time Factors | 1971 |
Effect of splenectomy on the activity of drug-metabolizing enzymes in the liver of rats.
Topics: Animals; Anisoles; Biological Assay; Carbon Isotopes; Cytochromes; Enzyme Induction; Female; Hexobarbital; Leucine; Liver; Liver Circulation; Microsomes, Liver; Nitroso Compounds; Paralysis; Parathion; Phenobarbital; Rats; Sleep; Spleen; Splenectomy; Time Factors; Zoxazolamine | 1971 |
Propylene glycol as a drug solvent in pharmacologic studies.
Topics: Animals; Anticonvulsants; Drug Interactions; Hexobarbital; Mice; Motor Activity; Phenobarbital; Propylene Glycols; Seizures; Sleep; Solubility; Solvents; Time Factors; Tremor | 1971 |
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat.
Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1971 |
Effect of phenobarbital on the restoration of impaired drug metabolism in carbon tetrachloride-induced liver damage.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Clinical Enzyme Tests; Cytochromes; Enzyme Activation; Hexobarbital; Injections, Subcutaneous; Liver; Liver Cirrhosis, Experimental; Male; Nitrophenols; Organ Size; Phenobarbital; Rats; Time Factors | 1971 |
Influence of hydrophobic character on the relative rate of oxidation of drugs by rat liver microsomes.
Topics: Aniline Compounds; Animals; Barbiturates; Caffeine; Chemical Phenomena; Chemistry, Physical; Chlorine; Codeine; Ephedrine; Fatty Alcohols; Hexobarbital; Kinetics; Male; Mathematics; Microsomes, Liver; Mixed Function Oxygenases; Naphthalenes; Oxidoreductases; Phenobarbital; Physostigmine; Rats; Solubility; Structure-Activity Relationship | 1971 |
Induction and repression of microsomal drug-metabolizing enzymes by polycyclic hydrocarbons and phenobarbital: theoretical models.
Topics: Allosteric Regulation; Animals; Benz(a)Anthracenes; Benzopyrenes; Chlordan; Enzyme Induction; Enzyme Repression; Ethionine; Fluorenes; Genes, Regulator; Hexobarbital; Meperidine; Methylcholanthrene; Microsomes, Liver; Models, Biological; Operon; Oxidoreductases; Phenobarbital; Rats; Zoxazolamine | 1971 |
Effects of non-steroid antirheumatic agents on microsomal drug-metabolizing enzymes of rat liver.
Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Aspirin; Benzyl Compounds; Enzyme Induction; Flufenamic Acid; Hexobarbital; In Vitro Techniques; Indazoles; Indomethacin; Liver; Male; Mefenamic Acid; Methylamines; Methyltransferases; Microsomes, Liver; Organ Size; Oxidoreductases; Phenobarbital; Pyrazoles; Rats; Salicylamides; Salicylates; Sleep; Sodium Salicylate | 1971 |
Studies on the mechanism of tolerance to nicotine-induced elevations of urinary catecholamines.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Catechol O-Methyltransferase; Catecholamines; Catechols; Drug Tolerance; Enzyme Induction; Fluorometry; Heart; Hexobarbital; In Vitro Techniques; Liver; Male; Metabolism; Methylcholanthrene; Methyltransferases; Monoamine Oxidase; Myocardium; Nerve Endings; Nicotine; Norepinephrine; Oxidoreductases; Perfusion; Phenobarbital; Rats; S-Adenosylmethionine; Sleep; Time Factors; Tritium; Zoxazolamine | 1971 |
Inductive effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane(DDT), phenobarbital, and benzpyrene on microsomal cytochrome B450, ethyl isocyanide spectra, and metabolism in vivo of zoxazolamine and hexobarbital in the mouse.
Topics: Animals; Benzopyrenes; Cyanides; Cytochrome P-450 Enzyme System; DDT; Enzyme Induction; Hexobarbital; Male; Mice; Microsomes, Liver; Paralysis; Phenobarbital; Proteins; Sleep; Spectrum Analysis; Time Factors; Zoxazolamine | 1971 |
Effect of partial liver resection and phenobarbital on the restoration of impaired drug metabolism in carbon tetrachloride induced liver damage.
Topics: Animals; Benzoates; Carbon Tetrachloride Poisoning; Cytochromes; Enzyme Induction; Hepatectomy; Hexobarbital; Hydroxylation; Liver; Liver Cirrhosis; Liver Regeneration; Male; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1971 |
Effect of chronic treatment with therapeutically useful antibiotics on the response of certain pharmacologic agents in the rat.
Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Chlordan; Chlortetracycline; Dactinomycin; Drug Antagonism; Drug Tolerance; Enzyme Induction; Enzymes; Hexobarbital; Male; Oxytetracycline; Penicillins; Phenobarbital; Rats; Sleep; Streptomycin | 1970 |
Effect of administration of 3-aminotriazole on the activity of microsomal drug-metabolizing enzyme systems of rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Blood Proteins; Brain; Brain Chemistry; Cytochromes; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Nitrobenzenes; Pentobarbital; Phenobarbital; Pigments, Biological; Rats; Spectrophotometry; Triazoles; Zoxazolamine | 1967 |
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats.
Topics: Aging; Anesthesia; Animals; Carisoprodol; Female; Hexobarbital; Injections, Intraperitoneal; Insecticides; Liver; Male; Microsomes; Paralysis; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Rats; Sex Factors; Strychnine; Time Factors; Zoxazolamine | 1968 |
Effect of phenobarbital and methylcholanthrene treatment on drug-induced difference spectrum of liver microsomes.
Topics: Aniline Compounds; Animals; Cytochromes; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry | 1969 |
Differences in the oxidative metabolism of drugs by liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Oxidoreductases; Pentobarbital; Phenobarbital; Proadifen; Rats; Sex Factors; Starvation; Thyroxine; Zoxazolamine | 1969 |
Studies with N-methyl emetine.
Topics: Alkaloids; Animals; Carbon Isotopes; Depression, Chemical; Emetine; Female; Hexobarbital; In Vitro Techniques; Leucine; Methylation; Microsomes, Liver; Phenobarbital; Phenylalanine; Protein Biosynthesis; Rats; Stimulation, Chemical | 1969 |
Factors affecting the metabolism and response to hexobarbital.
Topics: Age Factors; Animals; Body Weight; Breeding; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Sex Factors; Sleep; Species Specificity; Time Factors | 1969 |
Increased drug-metabolizing activity without increased cytochrome P-450 in rats treated with phenolic antioxidants.
Topics: Animals; Antioxidants; Cresols; Cytochromes; Female; Hexobarbital; Liver; Phenobarbital; Phenols; Rats; Stimulation, Chemical | 1969 |
[Temporal course of the induction of delta aminolevulinic acid synthetase, hexobarbital decorporating enzyme and cytochrome P450 in the rat liver following phenobarbital administration].
Topics: Animals; Cytochromes; Enzyme Induction; Hexobarbital; Liver; Lyases; Male; Microsomes, Liver; Phenobarbital; Rats; Time Factors | 1969 |
Interference of hepatic drug metabolism in Plasmodium berghei-infected mice and its therapeutic modification: A study of hexobarbital sleeping time and phenobarbital-induced liver stimulation.
Topics: Animals; Female; Hematocrit; Hexobarbital; Liver; Malaria; Mice; Organ Size; Phenobarbital; Plasmodium; Sleep | 1970 |
[Increased hydroxylation of estrogens in humans after administration of drugs. Demonstration by HTO analysis of body water].
Topics: Adult; Aged; Barbiturates; Biotransformation; Body Fluids; Cyclophosphamide; Enzyme Induction; Estradiol; Female; Hexobarbital; Humans; Hydroxides; Male; Middle Aged; Mixed Function Oxygenases; Phenobarbital; Stimulation, Chemical; Sulfadimethoxine; Thiopental; Tritium; Water | 1970 |
Aryl 4-hydroxylase, cytochrome P-450 and microsomal lipids in essential fatty acid deficiency.
Topics: Aniline Compounds; Animals; Body Weight; Cytochromes; Deficiency Diseases; Fatty Acids, Essential; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Phospholipids; Rats; Testis | 1970 |
Influence of partial hepatectomy on the induction of liver microsomal drug-metabolizing enzymes produced by phenobarbital. A biochemical and ultrastructural study.
Topics: Animals; Endoplasmic Reticulum; Enzyme Induction; Female; Hepatectomy; Hexobarbital; Liver; Microscopy, Electron; Microsomes, Liver; Phenobarbital; Rats; Strychnine; Time Factors | 1970 |
Studies on stability of drugs in frozen systems. II. The stabilities of hexobarbital sodium and phenobarbital sodium in frozen aqueous solutions.
Topics: Drug Stability; Freezing; Hexobarbital; Hydrogen-Ion Concentration; Phenobarbital; Sodium; Solutions; Time Factors | 1970 |
[Electrocorticogram, steady potential of the brain and energy-rich phosphate fractions of the cerebral cortex during anesthetic overdosage, ischemia and cyanide poisoning].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Anesthetics; Animals; Cerebral Cortex; Chloral Hydrate; Chlorobutanol; Cyanides; Depression, Chemical; Electroencephalography; Ethers; Female; Guinea Pigs; Hexobarbital; Ischemia; Male; Membrane Potentials; Methoxyflurane; Pentobarbital; Phenobarbital; Phosphates; Phosphocreatine; Propanidid; Rats; Urethane | 1970 |
Substrate-induced spectral change of liver microsomes in phenobarbital and methylcholanthrene-treated male and female rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Chemical Phenomena; Chemistry; Female; Hexobarbital; Male; Meperidine; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidation-Reduction; Phenobarbital; Proteins; Rats; Spectrophotometry; Spectrum Analysis; Zoxazolamine | 1970 |
Effect on newborn rats of perinatal exposure to phenobarbital.
Topics: Acetaminophen; Animals; Animals, Newborn; Antipyrine; Brain; Female; Hexobarbital; Microsomes, Liver; Nitrophenols; Phenobarbital; Pregnancy; Pyrazoles; Rats; Sleep; Spectrophotometry | 1970 |
Induction of phenobarbital of microsomal mixed oxidase enzymes in regenerating rat liver.
Topics: Aniline Compounds; Animals; Cell Division; Dietary Proteins; DNA; Enzyme Induction; Hepatectomy; Hexobarbital; Kinetics; Liver Regeneration; Male; Metabolism; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Time Factors; Tritium | 1970 |
Effects of storage on hepatic microsomal cytochromes and substrate-induced difference spectra.
Topics: Aniline Compounds; Animals; Benzphetamine; Cyanides; Cytochromes; Drug Storage; Enzyme Induction; Heme; Hemoglobins; Hexobarbital; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methemoglobin; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrum Analysis; Time Factors | 1970 |
Long-term variation in basal and phenobarbital-stimulated oxidative drug metabolism in the rat.
Topics: Aminopyrine; Animals; Basal Metabolism; Hexobarbital; In Vitro Techniques; Liver; Male; Nitrophenols; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats; Sleep; Time Factors | 1970 |
Effects of malarial infection on host microsomal drug-metabolizing enzymes.
Topics: Aniline Compounds; Animals; Anisoles; Blood Cell Count; Cytochromes; Endoplasmic Reticulum; Enzyme Induction; Hexobarbital; Malaria; Male; Microsomes, Liver; Morphinans; Nitrophenols; Phenobarbital; Phenylhydrazines; Plasmodium; Proteins; Rats; Reticulocytes; Sleep; Time Factors | 1970 |
[Studies on the effect of an inhalation anesthesia and surgery on the liver function with special reference to halothane. 2].
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Aspartate Aminotransferases; Bilirubin; Bromides; Enzyme Induction; Female; Glutamate Dehydrogenase; Halothane; Hexobarbital; L-Lactate Dehydrogenase; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Sleep; Stimulation, Chemical | 1970 |
Further observations upon the effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Hexobarbital; Liver; Liver Diseases; Male; Microscopy, Electron; Necrosis; Phenobarbital; Rats; Stimulation, Chemical | 1971 |
Effects of extraction with isooctane upon the properties of liver microsomes.
Topics: Alkanes; Aniline Compounds; Animals; Blood Proteins; Cytochromes; Hexobarbital; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrum Analysis | 1971 |
[Comparative animal experiments on the influence of muscle relaxants and narcotics on intraocular pressure].
Topics: Anesthesia, General; Anesthetics; Animals; Barbiturates; Chloralose; Female; Fentanyl; Gallamine Triethiodide; Halothane; Hexobarbital; Injections, Intravenous; Intraocular Pressure; Male; Narcotics; Nitrous Oxide; Phenobarbital; Propanidid; Rabbits; Succinylcholine; Urethane | 1971 |
The metabolism of hexobarbital in mice and methodology for isolation and quantitation of its metabolites in vivo and in vitro.
Topics: Alcohols; Animals; Cell-Free System; Countercurrent Distribution; Female; Half-Life; Hexobarbital; Hydrocarbons, Halogenated; Ketones; Kinetics; Male; Mass Spectrometry; Methods; Mice; Microsomes, Liver; Phenobarbital; Phosphates; Stimulation, Chemical; Time Factors | 1971 |
[Phenobarbital and hexobarbital solubility in relation to their biologic activity].
Topics: Dioxins; Ethanol; Hexobarbital; Phenobarbital; Solubility; Solutions; Water | 1971 |
Induction of hepatic microsomal hydroxylating enzymes by technical piperonyl butoxide and some of its analogs.
Topics: Animals; Anisoles; Biotransformation; Body Weight; Cytochromes; Dioxoles; Enzyme Induction; Ethers, Cyclic; Eugenol; Female; Hexobarbital; Liver; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Organ Size; Organophosphonates; Organothiophosphorus Compounds; Phenobarbital; Rats | 1971 |
The effect of hemorrhage on the rate of hexobarbital biotransformation in the dog.
Topics: Aniline Compounds; Animals; Biotransformation; Cytochromes; Dogs; Enzyme Induction; Female; Hemorrhage; Hexobarbital; Male; Microsomes, Liver; Phenobarbital | 1971 |
[On the possibility of transmission to the regenerating liver of pharmacometabolic "induction". I. Time elapsed between the administration of the inducing drug and hepatectomy and maximum enzymatic activity in the newly formed liver].
Topics: Animals; Enzyme Induction; Female; Hepatectomy; Hexobarbital; Liver; Liver Regeneration; Phenobarbital; Rats; Strychnine | 1967 |
["Inducing" power of a drug on hepatic pharmacometabolic enzymes and on variations in relation to situations of the organism which can modify the metabolic degradation of the drug itself].
Topics: Animals; Enzyme Induction; Female; Hexobarbital; Liver; Male; Phenobarbital; Rats; Strychnine | 1967 |
Intravenous anaesthesia for the ambulant patient.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Anesthesia, Conduction; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Barbiturates; Blood Pressure; Female; Guinea Pigs; Halothane; Hexobarbital; Humans; Methohexital; Mice; Middle Aged; Phenobarbital; Secobarbital; Succinylcholine; Thiopental | 1968 |
Stress-induced alterations in microsomal drug metabolism in the adrenalectomized rat.
Topics: Adrenalectomy; Aniline Compounds; Animals; Cold Temperature; Enzyme Induction; Hexobarbital; Hydrocortisone; In Vitro Techniques; Liver; Male; Microsomes; Morphine; Organ Size; Phenobarbital; Rats; Steroids; Stress, Physiological; Thymus Gland | 1968 |
Separation of oxy- and thiobarbiturates by thin-layer chromatography.
Topics: Amobarbital; Barbiturates; Chromatography, Thin Layer; Hexobarbital; Methods; Methohexital; Pentobarbital; Phenobarbital; Secobarbital; Thiopental | 1968 |
Effects of various chemical agents on drug metabolism and cholesterol biosynthesis.
Topics: Acetanilides; Acetates; Aminopyrine; Animals; Anticholesteremic Agents; Benzopyrenes; Carbon Isotopes; Chloramphenicol; Cholesterol; Depression, Chemical; Drug Synergism; Ethers; Ethylamines; Hexobarbital; Insecticides; Iproniazid; Liver; Male; Mevalonic Acid; Microsomes; Nitrophenols; Phenobarbital; Proadifen; Rabbits; Rats; Sleep; Time Factors | 1968 |
Enhanced biliary excretion of thyroxine glucuronide in rats pretreated with benzpyrene.
Topics: Animals; Autoradiography; Benzopyrenes; Bile; Bile Ducts; Chromatography, Paper; Female; Glucuronates; Hexobarbital; In Vitro Techniques; Iodine Isotopes; Male; Phenobarbital; Phenols; Rats; Sex Factors; Stimulation, Chemical; Thyroxine; Transferases | 1968 |
Hepatic drug metabolism after phenobarbital or 3-methylcholanthrene pretreatment of rats bearing a pituitary tumor.
Topics: Aminopyrine; Animals; Benzopyrenes; Hexobarbital; Liver; Male; Methylcholanthrene; Phenobarbital; Pituitary Neoplasms; Rats; Zoxazolamine | 1968 |
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental | 1968 |
Metabolism of hexobarbital and zoxazolamine by placentae and fetal liver supernatant fraction and response to phenobarbital and chlordane treatment.
Topics: Age Factors; Animals; Chlordan; Female; Fetus; Hexobarbital; Liver; Phenobarbital; Placenta; Pregnancy; Rabbits; Zoxazolamine | 1968 |
Studies on hepatic microsomal N- and O-dealkylation of morphine analogues.
Topics: Animals; Carbon Monoxide; Cytochromes; Fasting; Hexobarbital; Hot Temperature; Kinetics; Light; Liver; Male; Microsomes; Morphine; Phenobarbital; Rats | 1968 |
Effect of partial hepatectomy of the responsiveness of microsomal enzymes and cytochrome P-450 to phenobarbital or 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Cytochromes; Enzyme Induction; Hepatectomy; Hexobarbital; Liver; Liver Regeneration; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Organ Size; Phenobarbital; Proteins; Rats | 1968 |
[Microcrystalloscopic reaction on hexenal and phenobarbital].
Topics: Crystallography; Hexobarbital; Methods; Phenobarbital | 1968 |
Responses of isolated, perfused rat and guinea pig lungs to barbiturates.
Topics: Animals; Female; Guinea Pigs; Hexobarbital; In Vitro Techniques; Lung; Male; Pentobarbital; Perfusion; Phenobarbital; Rats; Respiration; Species Specificity; Spirometry; Thiopental; Vascular Resistance | 1968 |
[Behavior of energy-rich phosphates in the cerebral cortex during elimination of electrical activity by high doses of various anesthetics].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Blood Pressure; Cats; Cerebral Cortex; Chloral Hydrate; Electroencephalography; Electrophysiology; Guinea Pigs; Heart Rate; Hexobarbital; Methoxyflurane; Pentobarbital; Phenobarbital; Phenylacetates; Phosphates; Phosphocreatine; Rats; Respiration, Artificial; Urethane | 1968 |
[Comparison of distribution, narcotic activity and metabolic elimination of the optical antipodes of methylphenobarbital].
Topics: Animals; Barbiturates; Brain; Female; Hexobarbital; Liver; Phenobarbital; Rats; Stereoisomerism; Time Factors | 1968 |
Induction of microsomal hydroxylase: involvement of a second factor besides cytochrome P-450.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochromes; DDT; Enzyme Induction; Female; Formaldehyde; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats | 1968 |
[The influence of anti-inflammatory agents on the central effects of barbiturates].
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Barbiturates; Brain; Drug Synergism; Female; Hexobarbital; Male; Mice; Muscle Relaxants, Central; Phenobarbital; Phenylbutazone; Sodium Salicylate | 1968 |
On the problem of possible other forms of cytochrome P450 in liver microsomes.
Topics: Animals; Benzopyrenes; Cytochromes; Female; Hexobarbital; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrum Analysis | 1969 |
Barbiturate mortality in hypothyroid and hyperthyroid rats.
Topics: Amobarbital; Animals; Barbiturates; Basal Metabolism; Body Temperature; Body Weight; Hexobarbital; Hyperthyroidism; Hypothyroidism; Male; Pentobarbital; Phenobarbital; Rats; Thiopental; Thyroidectomy; Triiodothyronine; Zoxazolamine | 1969 |
Demethylation studies. VI. The inhibition of hepatic microsomal oxygenation by 2,4-dichloro(6-phenylphenoxy)ethylamine and related compounds.
Topics: Aminopyrine; Amitriptyline; Animals; Butylamines; Carbamates; Carbon Isotopes; Dextropropoxyphene; Dogs; Ethylamines; Hexobarbital; Imipramine; In Vitro Techniques; Liver; Male; Mice; Microsomes; Morphinans; Naphthalenes; Nitriles; Phenethylamines; Phenobarbital; Propylamines; Rats | 1969 |
Factors affecting the rate of disappearance of amphetamine in rats.
Topics: Age Factors; Animals; Dextroamphetamine; Estradiol; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Sex Factors; Time Factors; Zoxazolamine | 1969 |
The influence of lynestrenol on the rate of metabolism of phenobarbital, phenytoin and hexobarbital in mice.
Topics: Animals; Bemegride; Electroshock; Enzyme Induction; Female; Hexobarbital; Lynestrenol; Male; Mice; Phenobarbital; Phenytoin; Seizures; Sleep; Time Factors | 1969 |
Induction of drug metabolism. 3. Further information of a new P-450 hemoprotein after treatment of rats with 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Binding Sites; Blood Proteins; Cold Temperature; Cytochromes; Hexobarbital; Lipase; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Protein Binding; Proteins; Rats | 1969 |
[Identification of barbiturate metabolites by means of mass spectrometry and infrared spectroscopy].
Topics: Amobarbital; Barbiturates; Cycloheptanes; Hexobarbital; Infrared Rays; Methods; Pentobarbital; Phenobarbital; Spectrum Analysis | 1969 |
The influence of age, sex and drug treatment on microsomal drug metabolism in four rat strains.
Topics: Age Factors; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphine; Phenobarbital; Proteins; Rabbits; Rats; Sex Factors; Species Specificity | 1969 |
Stereoselective metabolism of the enantiomers of hexobarbital.
Topics: Animals; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Sex Factors; Sleep; Stereoisomerism; Time Factors | 1969 |
Effect of anaesthetics on mature infections of Schistosoma mansoni in the white mouse.
Topics: Amobarbital; Animals; Barbiturates; Chloroform; Ethyl Ethers; Halothane; Hexobarbital; In Vitro Techniques; Liver Circulation; Mesenteric Arteries; Mesenteric Veins; Mice; Pentobarbital; Phenobarbital; Schistosoma; Schistosomiasis; Secobarbital | 1965 |
[Acute isoniazid poisoning. Points of onset in the macro-organism, symptoms and measures of treatment].
Topics: Amino Acids; Ammonia; Animals; Barbiturates; Biochemical Phenomena; Biochemistry; Blood; Hexobarbital; Humans; Isoniazid; Mice; Phenobarbital; Prognosis; Pyridoxine; Rabbits; Rats; Seizures; Vitamins | 1965 |
Time course differences in the metabolism of drugs by hepatic microsomes from rats, rabbits and mice.
Topics: Aminopyrine; Animals; Benzoates; Benzopyrenes; Codeine; Hexobarbital; In Vitro Techniques; Liver; Mice; Microsomes; Phenobarbital; Rabbits; Rats; Species Specificity; Sulfonamides; Time; Zoxazolamine | 1966 |
The effect of actinomycin D on post-phenobarbital activity of hepatic microsomal drug-metabolizing enzymes in the rat.
Topics: Aminopyrine; Animals; Dactinomycin; Hexobarbital; In Vitro Techniques; Liver; Microsomes; Phenobarbital; Rats | 1966 |
Effect of Tiomebumal upon resistance of mice to anoxia.
Topics: Amobarbital; Animals; Barbiturates; Brain; Carbon Dioxide; Hexobarbital; Hypoxia; Mice; Oxygen Consumption; Phenobarbital; Thiopental | 1966 |
Identification of some barbiturates by paper and thin-layer chromatography.
Topics: Amobarbital; Barbiturates; Chromatography, Paper; Chromatography, Thin Layer; Hexobarbital; Pentobarbital; Phenobarbital; Secobarbital | 1966 |
Inhibition of drug metabolism. IV. Induction of drug metabolism by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and 2,4-dichloro-6-phenylphenoxyethylamine HBr (Lilly 18947) and the effect of induction on the inhibitory properties of SKF 525-A
Topics: Animals; Antimetabolites; Enzymes; Hexobarbital; Male; Microsomes; Morphine; Phenobarbital; Proadifen; Proteins; Rats | 1966 |
The effect of chronic phenobarbital administration on some hepatic drug-metabolizing enzyme activities in the rat.
Topics: Animals; Benzopyrenes; Codeine; Hexobarbital; Liver; Male; Microsomes; Nitrobenzenes; Phenobarbital; Rats | 1966 |
The induction of drug-metabolizing enzymes in rat liver during growth and regeneration. A biochemical and ultrastructural study.
Topics: Animals; Butylene Glycols; Endoplasmic Reticulum; Enzyme Induction; Female; Hepatectomy; Hexobarbital; Liver; Liver Regeneration; Microscopy, Electron; Microsomes; Pentobarbital; Phenobarbital; Rats; Strychnine; Tranquilizing Agents | 1967 |
Estimation of the turnover rate of barbiturate sidechain oxidation enzyme in rat liver.
Topics: Animals; Glucosyltransferases; Hexobarbital; In Vitro Techniques; Liver; Male; Metabolic Diseases; Mutation; Phenobarbital; Rats | 1967 |
Synthesis and basic pharmacology of N-substituted and N,N'-disubstituted ALLYL BARBITURATES.
Topics: Animals; Barbiturates; Behavior, Animal; Central Nervous System; Chemistry, Organic; Hexobarbital; Male; Mice; Organic Chemistry Phenomena; Phenobarbital | 1967 |
Effect of pretreatment of rabbits with phenobarbital or 3-methylcholanthrene on the distribution of drug-metabolizing enzyme activity in subfractions of hepatic microsomes.
Topics: Aminopyrine; Amphetamine; Animals; Benzopyrenes; Codeine; Hexobarbital; Liver; Male; Methylcholanthrene; Microscopy, Electron; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pigments, Biological; Rabbits; Zoxazolamine | 1967 |
Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies.
Topics: Animals; Barbiturates; Drug Interactions; Half-Life; Hexobarbital; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Comparison of hepatic drug-metabolizing enzymes induced by 3-methylcholanthrene and phenobarbital between pre- and postnatal rats.
Topics: Aminopyrine; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fetus; Gestational Age; Hexobarbital; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1984 |
Nonsubstrate induction of a soluble bacterial cytochrome P-450 monooxygenase by phenobarbital and its analogs.
Topics: Bacillus megaterium; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Hot Temperature; Kinetics; Oxygenases; Phenobarbital; Structure-Activity Relationship | 1983 |
[Liver mono-oxygenases and the pharmacodynamics of carminomycin and rubomycin].
Topics: Animals; Carubicin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Induction; Hexobarbital; Liver; Male; Mice; Mice, Inbred CBA; Oxygenases; Phenobarbital; Proadifen; Sleep; Time Factors | 1984 |
Potentiated toxicity of 2-sec-butylphenyl methylcarbamate (BPMC) by O,O-dimethyl O-(3-methyl-4-nitrophenyl)phosphorothioate (fenitrothion) in mice; relationship between acute toxicity and metabolism of BPMC.
Topics: Animals; Carbamates; Drug Synergism; Fenitrothion; Hexobarbital; In Vitro Techniques; Insecticides; Male; Mice; Mice, Inbred ICR; Mixed Function Oxygenases; Phenobarbital; Sleep | 1984 |
Capillary gas chromatography on fused silica columns with splitless injection: the determination of phenobarbital in blood plasma.
Topics: Chromatography, Gas; Hexobarbital; Humans; Phenobarbital | 1983 |
Interaction between manganese and phenobarbital on hexobarbital hypnosis in the male rat.
Topics: Animals; Biotransformation; Drug Interactions; Hexobarbital; Hypnosis, Anesthetic; Male; Manganese; Microsomes, Liver; Phenobarbital; Rats | 1983 |
Liver microsomal cytochrome P-450-dependent O-dealkylation reaction in various animals.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dealkylation; Guinea Pigs; Hexobarbital; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microsomes, Liver; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Influence of impairment of the immune system on hepatic biotransformation reactions, their postnatal development and inducibility.
Topics: Animals; Animals, Newborn; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Liver; Male; Methylnitrosourea; Phenobarbital; Rats; Rats, Inbred Strains; Sleep; Splenectomy; Thymectomy; Thymus Gland | 1983 |
Loss of substrate binding capacity of the hepatic microsomal cytochrome P-450 in Fasciola hepatica infected rats: toxicological implications.
Topics: Alcohol Oxidoreductases; Animals; Cytochrome P-450 Enzyme System; Fasciola hepatica; Fascioliasis; Hexobarbital; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Sleep | 1982 |
Inhibition of lipid peroxide decomposition by compounds which bind with cytochrome p-450.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Lipid Peroxides; Male; Microsomes, Liver; Peroxidases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1983 |
[The effect of thiamine deficiency on the actions of drugs affecting the central nervous system in rats (author's transl)].
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Brain; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Hypothalamus; Male; Neurons; Phenobarbital; Proadifen; Rats; Sleep; Tetrabenazine; Thiamine Deficiency | 1980 |
Effect of total body X-irradiation on the hexobarbital oxidase activity in the rat liver.
Topics: Alcohol Oxidoreductases; Aminopyrine N-Demethylase; Animals; Enzyme Induction; Hexobarbital; Lipid Peroxides; Liver; Male; Phenobarbital; Rats; X-Rays | 1980 |
Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat.
Topics: Animals; Erythrocytes; Hexobarbital; Kinetics; Liver; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Rats; Rats, Inbred Strains; Thiopental | 1982 |
The effect of various modifiers on rat microsomal peroxidase kinetics.
Topics: Aniline Compounds; Animals; Hexobarbital; Kinetics; Lipid Peroxides; Male; Microsomes, Liver; Peroxidases; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1982 |
Potentiation of barbiturate hypnosis by probenecid: differential effect in tolerant animals.
Topics: Animals; Barbiturates; Brain; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Hexobarbital; Injections, Intraventricular; Liver; Male; Motor Activity; Phenobarbital; Probenecid; Rats; Reflex | 1981 |
Cimetidine: a specific inhibitor of hepatic aryl hydrocarbon hydroxylase (AHH) in the rat.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cimetidine; Guanidines; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Sleep | 1981 |
Enzyme inducer effects after liver denervation in the rat.
Topics: Animals; Denervation; Enzyme Induction; Female; Hexobarbital; Liver; Phenobarbital; Rats; Sleep; Swimming; Time Factors | 1981 |
Oxidation-reduction states of pyridine nucleotide and cytochrome P-450 during mixed-function oxidation in perfused rat liver.
Topics: Aminopyrine; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Liver; Male; Mixed Function Oxygenases; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
[Activity of nonspecific hepatic oxidases and the biological effects of the antineoplastic antibiotic adriamycin].
Topics: Animals; Doxorubicin; Hexobarbital; Liver; Male; Mice; Mice, Inbred CBA; Oxidoreductases; Phenobarbital; Proadifen; Sleep | 1981 |
Interaction between cadmium and phenobarbital on the activity of the hepatic microsomal monooxygenase system in the male rat.
Topics: Animals; Biotransformation; Cadmium; Drug Interactions; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Sleep; Time Factors | 1980 |
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents.
Topics: Adult; Aged; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Enzyme Induction; Female; Hexobarbital; Humans; Inactivation, Metabolic; Kinetics; Liver; Male; Metabolic Clearance Rate; Middle Aged; Phenobarbital; Phenytoin; Rifampin | 1980 |
Inhibition of cytochrome P-448 mixed function oxidase activity following administration of 9-hydroxyellipticine to rats.
Topics: Alkaloids; Aniline Compounds; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1980 |
Development and regression of the hepatic microsomal enzyme induction and stimulation of biliary excretion produced by phenobarbital in rats.
Topics: Animals; Bile; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Stimulation, Chemical; Time Factors | 1980 |
Hexobarbital-binding, hydroxylation and hexobarbital-dependent hydrogen peroxide production in hepatic microsomes of guinea pig, rat and rabbit.
Topics: Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Hexobarbital; Humans; Hydrogen Peroxide; Hydroxylation; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rabbits; Rats | 1980 |
Restriction of hexobarbital metabolism by t-butyl hydroperoxide in perfused rat liver.
Topics: Animals; Hexobarbital; In Vitro Techniques; Liver; Male; Oxygen Consumption; Peroxides; Phenobarbital; Rats; tert-Butylhydroperoxide | 1980 |
[An analysis of the mechanism of the resistance to barbiturate action by using exogenous RNA].
Topics: Animals; Barbiturates; Dactinomycin; Drug Resistance; Drug Tolerance; Hexobarbital; Methods; Microsomes, Liver; Organ Specificity; Phenobarbital; Protein Biosynthesis; Proteins; Rats; RNA; Sleep; Time Factors | 1993 |
Experimental model of cirrhosis in rabbits exposed to carbon tetrachloride by inhalation.
Topics: Administration, Inhalation; Animals; Body Weight; Carbon Tetrachloride Poisoning; Hexobarbital; Liver; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Microsomes, Liver; Phenobarbital; Rabbits | 1995 |
Neonatal phenobarbital-induced defects in age- and sex-specific growth hormone profiles regulating monooxygenases.
Topics: Aging; Animals; Animals, Newborn; Female; Growth Hormone; Hexobarbital; Male; Microsomes, Liver; Mixed Function Oxygenases; Periodicity; Phenobarbital; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1995 |
The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Longitudinal Studies; Male; Metabolic Clearance Rate; Phenobarbital; Rats; Rats, Inbred BN; Stereoisomerism | 1994 |
The effect of the cytochrome P-450 system inducers on the development of Drosophila melanogaster.
Topics: Aminophylline; Animals; Cytochrome P-450 Enzyme System; Drosophila melanogaster; Ecdysterone; Enzyme Induction; Female; Hexobarbital; Larva; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide | 1993 |
Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners.
Topics: Amino Acid Sequence; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Feprazone; Hexobarbital; Humans; Isoenzymes; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Phenobarbital; Phenylbutazone; Rabbits; Rats; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity; Templates, Genetic | 1997 |
[The influence of hexobarbital and phenobarbital on alcohol elimination in rabbits].
Topics: Animals; Biological Transport; Ethanol; Hexobarbital; Lagomorpha; Phenobarbital; Rabbits | 1960 |
Effect of ethionine and carbon tetrachloride on urethan and phenobarbital induced changes in hexobarbital action.
Topics: Carbon Tetrachloride; Ethionine; Hexobarbital; Phenobarbital; Urethane | 1961 |
Rapid differentiation of barbiturates in blood serum by thin-layer chromatography.
Topics: Amobarbital; Barbiturates; Chromatography; Chromatography, Thin Layer; Hexobarbital; Pentobarbital; Phenobarbital; Serum | 1962 |
[Deviations in the pharmacodynamic action of various drugs by hypo- and hyperthermia. 2].
Topics: Acetylcholine; Aminobutyrates; Amphetamine; Amphetamines; Atropine; Chlordiazepoxide; Chlorpromazine; Cocaine; Convulsive Therapy; Electroconvulsive Therapy; Fever; Hexobarbital; Histamine; Hypothermia; Hypothermia, Induced; Lidocaine; Lobeline; Morphine; Papaverine; Phenobarbital; Promethazine; Thiopental | 1962 |
A comparison of the effects of six barbiturates and a placebo on insomnia and motility in psychiatric patients.
Topics: Barbiturates; Double-Blind Method; Female; Hexobarbital; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pentobarbital; Phenobarbital; Secobarbital; Sleep; Sleep Initiation and Maintenance Disorders | 1963 |
Enhanced phenobarbital induction of liver microsomal drug-metabolizing enzymes in mice infected with murine hepatitus virus.
Topics: Animals; Hepatitis Viruses; Hexobarbital; Liver; Mice; Phenobarbital; Strychnine | 1963 |
CONDITIONED SUPPRESSION IN RATS AND THE EFFECT OF PHARMACOLOGICAL AGENTS THEREON.
Topics: Amobarbital; Amphetamine; Amphetamines; Avoidance Learning; Barbiturates; Carisoprodol; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Conditioning, Psychological; Ethanol; Hexobarbital; Hypnotics and Sedatives; Meprobamate; Morphine; Phenobarbital; Rats; Research | 1963 |
[IDENTIFICATION OF SEDATIVES IN AQUEOUS SOLUTIONS AND URINE BY THIN-LAYER CHROMATOGRAPHY].
Topics: Barbiturates; Bemegride; Chromatography; Chromatography, Thin Layer; Glutethimide; Hexobarbital; Hypnotics and Sedatives; Pentobarbital; Phenobarbital; Research; Thalidomide; Thiopental; Urine | 1963 |
THE METABOLISM OF DRUGS BY LIVER MICROSOMES FROM ALLOXAN-DIABETIC RATS: LONG TERM DIABETES.
Topics: Alloxan; Aminopyrine; Aniline Compounds; Animals; Codeine; Diabetes Mellitus, Experimental; Hexobarbital; Insulin; Liver; Liver Glycogen; Metabolism; Microsomes, Liver; Pharmacology; Phenobarbital; Rats; Research | 1963 |
[SEPARATION OF SOME BARBITURATES WITH THIN LAYER CHROMATOGRAPHY AND THE EFFECT OF ADSORBENT BUFFERING].
Topics: Adsorption; Amobarbital; Barbiturates; Chromatography; Chromatography, Thin Layer; Hexobarbital; Phenobarbital; Research | 1964 |
[BRIEF INTRAVENOUS ANESTHESIA].
Topics: Anesthesia; Anesthesia, Intravenous; Barbiturates; Hexobarbital; Humans; Pharmacology; Phenobarbital; Thiopental | 1964 |
FACTORS THAT AFFECT THE STIMULATION OF THE MICROSOMAL DRUG ENZYMES INDUCED BY FOREIGN COMPOUNDS.
Topics: Acetanilides; Adrenocorticotropic Hormone; Benzopyrenes; Hexobarbital; Liver; Methylcholanthrene; Methyltestosterone; Microsomes; Nandrolone; Pharmacology; Phenobarbital; Pyrazoles; Rats; Research; Testosterone; Zoxazolamine | 1963 |
FACTORS AFFECTING HEPATIC MICROSOMAL ENZYME SYSTEMS INVOLVED IN DRUG METABOLISM.
Topics: Alloxan; Aminopyrine; Carcinoma, Hepatocellular; Chlordan; Chlorpromazine; Codeine; Hexobarbital; Jaundice; Jaundice, Obstructive; Liver; Liver Glycogen; Liver Neoplasms; Liver Regeneration; Microsomes; Phenobarbital; Portal System; Research; Starvation | 1963 |
THE PLACE OF ACETYLSALICYLIC ACID IN PSYCHOPHARMACOLOGY. AN EXPERIMENTAL STUDY.
Topics: Amphetamine; Amphetamines; Animals; Aspirin; Body Temperature Regulation; Chlordiazepoxide; Chlorpromazine; Electrophysiology; Ether; Guinea Pigs; Hexobarbital; Meprobamate; Mice; Morphine; Nikethamide; Pain; Pentylenetetrazole; Pharmacology; Phenobarbital; Poisoning; Psychopharmacology; Rabbits; Research; Sensory Receptor Cells; Sleep; Strychnine; Thiopental | 1963 |
KINETICS OF DRUG METABOLISM BY HEPATIC MICROSOMES.
Topics: Acetanilides; Chlorpromazine; Hexobarbital; Kinetics; Liver; Metabolism; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Morphine; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylbutazone; Rats; Research; Zoxazolamine | 1964 |
A RAPID METHOD FOR PARTIAL IDENTIFICATION OF BARBITURATES IN BLOOD USING THIN LAYER CHROMATOGRAPHY ON MICROSCOPE SLIDES.
Topics: Amobarbital; Barbiturates; Blood Chemical Analysis; Chromatography; Chromatography, Thin Layer; Hexobarbital; Humans; Microscopy; Phenobarbital | 1964 |
STUDY OF THE EFFECTS OF MORPHINE AND NALORPHINE.
Topics: Animals; Body Temperature Regulation; Chlordiazepoxide; Chlorpromazine; Electroshock; Ether; Guinea Pigs; Hexobarbital; Meprobamate; Morphine; Nalorphine; Nikethamide; Pharmacology; Phenobarbital; Research; Respiration; Seizures; Sleep; Thiopental | 1964 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmacology; Phenobarbital; Proadifen; Rats; Research; Sex; Steroid Hydroxylases; Testosterone | 1964 |
[ACCELERATED DRUG DEGRADATION BY ENZYME INDUCTION IN DOGS AFTER TREATMENT WITH PHENOBARBITAL].
Topics: Aminopyrine; Dogs; Enzyme Induction; Hexobarbital; Liver; Metabolism; Microsomes; Phenobarbital; Research; Toxicology | 1964 |
SIMULTANEOUS DETERMINATION OF BARBITURATES AND SALICYLATES BY ULTRAVIOLET SPECTROPHOTOMETRY.
Topics: Amobarbital; Barbiturates; Blood Chemical Analysis; Hexobarbital; Humans; Hydrogen-Ion Concentration; Phenobarbital; Salicylates; Secobarbital; Spectrophotometry; Spectrophotometry, Ultraviolet; Ultraviolet Rays | 1965 |
[BIOCHEMICAL AND ULTRASTRUCTURAL CHANGES CAUSED BY VARIOUS TREATMENTS AT THE HEPATIC LEVEL].
Topics: Hepatectomy; Hexobarbital; Liver; Metabolism; Microsomes; Phenobarbital; Proteins; Rats; Research; RNA; Strychnine | 1964 |
ENDOCRINE MODIFICATION OF DRUG RESPONSES IN THE RAT.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Ascorbic Acid; Barbiturates; Corticosterone; Hexobarbital; Histamine; Hypophysectomy; Injections, Intraperitoneal; Meprobamate; Pentobarbital; Pharmacology; Phenobarbital; Rats; Research; Stress, Physiological; Zoxazolamine | 1965 |
DIFFERENCES IN HEPATIC DRUG METABOLISM IN VARIOUS RABBIT STRAINS BEFORE AND AFTER PRETREATMENT WITH PHENOBARBITAL.
Topics: Aminopyrine; Amphetamine; Amphetamines; Aniline Compounds; Animals; Benzoates; Benzopyrenes; Chlorpromazine; Codeine; Hexobarbital; Liver; Metabolism; Phenobarbital; Rabbits; Research; Species Specificity; Transferases; Zoxazolamine | 1965 |
EFFECT OF GUM TRAGACANTH, URETHAN, AND PHENOBARBITAL ON HEXOBARBITAL NARCOSIS IN MICE.
Topics: Hexobarbital; Liver; Mice; Pharmacology; Phenobarbital; Research; Resins, Synthetic; Stupor; Tragacanth; Urethane | 1965 |
CENTRAL NERVOUS SYSTEM DEPRESSANT ACTIVITY OF MA1337, 3-(3-(4-M-CHLOROPHENYL-1-PIPERAZYL)PROPYL)-2,4(1H,3H)QUINAZOLINEDIONE HYDROCHLORIDE.
Topics: Amphetamine; Amphetamines; Behavior, Animal; Body Temperature; Catalepsy; Cats; Central Nervous System; Central Nervous System Depressants; Chlordiazepoxide; Chlorpromazine; Dogs; Hexobarbital; Hypnotics and Sedatives; Meprobamate; Mice; Pharmacology; Phenobarbital; Quinazolines; Quinazolinones; Research; Secobarbital; Toxicology | 1965 |
STRESS-DRUG INTERACTIONS: EVIDENCE FOR RAPID ENZYME INDUCTION.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Blood; Corticosterone; Dactinomycin; Drug Interactions; Enzyme Induction; Hexobarbital; Hypophysectomy; Liver; Meprobamate; Metabolism; Morphine; Pentobarbital; Pharmacology; Phenobarbital; Physiology; Rats; Research; Stress, Physiological | 1965 |
EFFECT OF PHENOBARBITAL DERIVATIVES ON THE DURATION OF HEXOBARBITAL HYPNOSIS.
Topics: Hexobarbital; Hypnosis; Pharmacology; Phenobarbital; Rats; Research | 1965 |
EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG-METABOLIZING ENZYMES.
Topics: Animals; Electrons; Endoplasmic Reticulum; Endoplasmic Reticulum, Smooth; Esterases; Hexobarbital; Histocytochemistry; Liver; Microscopy; Microscopy, Electron; Oxidoreductases; Pathology; Pharmacology; Phenobarbital; Rats; Research; Spectrophotometry; Tolbutamide; Toxicology | 1965 |
DRUG-INDUCED CHANGES IN STEROID METABOLISM.
Topics: Androsterone; Chromatography; Corticosterone; Cortisone; Dogs; Estradiol; Hexobarbital; Histamine H1 Antagonists; Hydrocortisone; Liver; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Phenylbutazone; Piperazines; Rats; Research; Steroids; Testosterone; Toxicology | 1965 |
THE STIMULATION OF DRUG METABOLISM IN VARIOUS RAT HEPATOMAS.
Topics: Aminopyrine; Aniline Compounds; Benzoates; Blood; Carcinoma, Hepatocellular; Chlordan; Hexobarbital; Liver; Liver Neoplasms; Metabolism; Neoplasms; Neoplasms, Experimental; p-Dimethylaminoazobenzene; Pathology; Pharmacology; Phenobarbital; Rats; Research; Sulfanilamide; Sulfanilamides; Sulfonamides; Toxicology | 1965 |
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Excitatory Amino Acid Antagonists; Hexobarbital; Liver; Liver Diseases; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 1981 |