hexobarbital has been researched along with morphine in 88 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 83 (94.32) | 18.7374 |
| 1990's | 1 (1.14) | 18.2507 |
| 2000's | 3 (3.41) | 29.6817 |
| 2010's | 1 (1.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fujimoto, Y; Nakata, C; Ogura, M; Shika, K; Tamada, T | 1 |
| Bridges, JW; Elcombe, CR; Illing, HP; King, LJ; Netter, KJ; Nimmo-Smith, RH; Wolf, CR | 1 |
| Ishii, Y; Kasuya, Y; Miyasaka, K; Watanabe, M | 1 |
| Kharalambieva, M; Micheva, M; Raĭnova, L; Staneva-Stoĭcheva, D | 1 |
| Bhattacharya, SK; Ghosal, S; Reddy, PK; Sharma, PV; Singh, AK | 1 |
| Beloiartsev, FF; Vladimirov, PV | 1 |
| Bhattacharya, SK; Chaudhuri, RK; Ghosal, S; Sharma, PV | 1 |
| Contreras, E; Quijada, L; Tamayo, L | 1 |
| Cenajek, D | 1 |
| Bantounova, I; Mihaylova, S; Stanoeva, L; Todorov, D; Yakimova, K | 1 |
| Eklöw-Låstbom, L; Moldéus, P; Orrenius, S | 1 |
| Achterrath-Tuckermann, U; Jakovlev, V; Stroman, F; Thiemer, K; von Schlichtegroll, A | 1 |
| Heppeler, G; Messerschmidt, O | 1 |
| Estabrook, RW; Werringloer, J | 1 |
| Abaskulieva, LI | 1 |
| Schlede, E | 1 |
| Gillette, JR; Kato, R | 1 |
| Greengard, P; Quinn, GP; Reid, MB | 1 |
| Gillette, JR; Stripp, B | 1 |
| Frohman, LA; Wilson, JT | 1 |
| Almirante, L; Murmann, W; Saccani-Guelfi, M | 1 |
| Gigon, PL; Gillette, JR; Gram, TE | 1 |
| Daly, MJ; Lightowler, JE; Pickering, RW | 1 |
| Burberi, S; Catanese, B; Cioli, V; Silvestrini, B | 1 |
| Kato, R; Onoda, K; Takayanagi, M | 1 |
| Leibman, KC | 1 |
| Kato, R; Onoda, K; Sasajima, M | 1 |
| Fuller, GC; Lal, H; Olshan, A; Puri, SK | 1 |
| Gillette, JR; Hamrick, M; Stripp, B; Zampaglione, N | 1 |
| Bousquet, WF; Miya, TS; Paolino, RM; Saunders, DR | 1 |
| Bhattacharya, SK; Ghosal, S; Sanyal, AK | 1 |
| Alvares, AP; Bickers, DR; Harber, LC; Kappas, A | 1 |
| Feller, DR; Lubawy, WC | 1 |
| Bass, A; Wilson, JT | 1 |
| Bolotova, MF | 1 |
| Feller, DR; Lewis, NJ; Witiak, DT | 1 |
| Burke, DH; Mann, DE | 1 |
| Bhattacharya, SK; Chaudhuri, RK; Ghosal, S; Sharma, PV; Singh, AK | 1 |
| Saito, C; Sakai, S; Takagi, H; Yamamoto, H; Yukawa, Y | 1 |
| Iida, M; Iwata, H; Miichi, H; Shikimi, T | 1 |
| Moriya, R; Nagawa, Y; Nakajima, R; Saji, Y; Take, Y; Yui, T | 1 |
| Ostrovskaia, RU; Parin, VV; Tsybina, NM | 1 |
| Inoki, R; Iwatsubo, K; Shigenaga, Y | 1 |
| Furukawa, T; Hanabusa, Y; Kushiku, K; Ono, N | 1 |
| Kato, R; Onoda, KI; Takanaka, A | 1 |
| Bär, H; Behrend, U; Fermum, R; Grisk, A; Möritz, KU | 1 |
| Kato, R | 1 |
| Kato, R; Onoda, K | 1 |
| Friedman, L; Quaife, ML | 1 |
| Coville, PF; Telford, JM | 1 |
| Katz, MH; Krop, S; Yen, HC | 1 |
| Fermum, R; Greiner-Leben, H; Hüller, H; Marx, E; Peters, R; Scheler, W | 1 |
| Furner, RL; Stitzel, RE | 1 |
| Mannering, GJ; Tephly, TR | 1 |
| Mannering, GJ; Stitzel, RE; Tephly, TR | 1 |
| Burgison, RM; Dietz, AJ | 1 |
| George, WJ; Tephly, TR | 1 |
| Anders, MW | 1 |
| Barzu, T; Cojocaru, Z; Cuparencu, B; Ghiran, D; Pitea, M; Safta, L; Ticsla, I | 1 |
| Furner, RL; Gram, TE; Stitzel, RE | 1 |
| Haas, H; Jantos, W | 1 |
| Anders, MW; Mannering, GJ | 1 |
| Richman, JE; Rudzik, AD; Trepanier, DL | 1 |
| Kaneto, H; Kosaka, N; Mino, T; Takasu, M | 1 |
| Itharat, A; Matsumoto, K; Reanmongkol, W; Watanabe, H | 1 |
| JACOB, J; MICHAUD, G | 1 |
| BEGUIN, M; FLEURY, C; FROMMEL, E; VON LEDEBUR, I | 1 |
| HAPKE, HJ | 1 |
| HOFFMEISTER, F | 1 |
| BOUSQUET, WF; MIYA, TS; RUPE, BD | 2 |
| BELLARE, RA; DELIWALA, CV; SHETH, UK; VAZ, A | 1 |
| LAUENER, H | 1 |
| ENDROECZI, E; KORANYI, L; LISSAK, K | 1 |
| HIDALGO, J; THOMPSON, CR | 1 |
| DEJONGE, MC; DONNER, R; FUNCKE, AB; HARMS, AF; MULDER, D; NAUTA, WT; RUEMKE, CL; TERSTEEGE, HM | 1 |
| FREY, R; KOLB, E | 1 |
| BEGUIN, M; FAMILY, S; FLEURY, C; FROMMEL, E; LEDEBUR, IV | 1 |
| MANNERING, GJ; RUBIN, A; TEPHLY, TR | 1 |
| MANNERING, GJ; RUBIN, A; TEPHYL, TR | 1 |
| CLIFT, JW; KIPLINGER, GF | 1 |
| FROMMEL, E; SEYDOUX, J | 1 |
| FOUTS, JR; JOHANNESSON, T; ROGERS, LA; WOODS, LA | 1 |
| BOUSQUET, WF; DRIEVER, CW | 1 |
88 other study(ies) available for hexobarbital and morphine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
[Inhibitory effects of methyl o-(4-hydroxy-3-methoxycinnamoyl) reserpate (CD-3400) on the central nervous system (author's transl)].
Topics: Agonistic Behavior; Animals; Avoidance Learning; Blepharoptosis; Body Temperature; Cats; Central Nervous System; Cooperative Behavior; Depression, Chemical; Drug Synergism; Electroencephalography; Female; Hexobarbital; Male; Methamphetamine; Mice; Morphine; Motor Activity; Pentylenetetrazole; Rats; Reserpine; Seizures; Serotonin | 1977 |
Measurement of substrate-induced oxygen uptake during microsomal drug oxidation using a gold micro-electrode.
Topics: Animals; Biphenyl Compounds; Cell-Free System; Gold; Hexobarbital; Kinetics; Male; Microelectrodes; Microsomes, Liver; Morphine; Morphine Derivatives; NADP; Naphthalenes; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Polarography; Proadifen; Rats | 1975 |
Potentiation of antitussive effect of codeine by some 1-dimethoxyphenyl-3-alkylaminobutanols in guinea pigs.
Topics: Amino Alcohols; Analgesics; Anesthesia; Animals; Antitussive Agents; Codeine; Dogs; Drug Synergism; Female; Guinea Pigs; Hemodynamics; Hexobarbital; In Vitro Techniques; Lethal Dose 50; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Pulmonary Stretch Receptors; Respiration; Trachea | 1977 |
[Neurophoarmacologic profile of an aminotetraline derivative].
Topics: Amphetamine; Analgesics; Animals; Apomorphine; Central Nervous System; Drug Interactions; Hexobarbital; Mice; Morphine; Motor Activity; Muscle Tonus; Naphthols; Nervous System; Pentylenetetrazole; Piperazines; Rats; Reserpine; Strychnine | 1977 |
Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Depression, Chemical; Drug Interactions; Glucosides; Glycosides; Hexobarbital; Iridoid Glucosides; Mice; Morphine; Motor Skills; Phenytoin; Plant Extracts; Plants, Medicinal; Pyrans; Pyrones; Rats; Sleep; Xanthenes; Xanthones | 1976 |
[Hemodynamic effects of hexenal, seduxen and morphine in patients with low cardiac output].
Topics: Cardiac Output; Diazepam; Heart Valve Diseases; Hexobarbital; Humans; Mitral Valve; Morphine; Preanesthetic Medication | 1976 |
Chemical constituents of gentianaceae XIV: tetraoxygenated and pentaoxygenated xanthones of Swertia purpurascens Wall.
Topics: Amphetamine; Animals; Chromatography, Thin Layer; Dogs; Drug Synergism; Ethers; Flavonoids; Hexobarbital; Magnetic Resonance Spectroscopy; Mice; Morphine; Motor Activity; Oxidation-Reduction; Piloerection; Plants, Medicinal; Rats; Rats, Inbred Strains; Reserpine; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Tremor; Xanthines | 1975 |
Sensitivity changes to morphine and other drugs induced by cholinergic blockade.
Topics: Amphetamine; Analgesics; Animals; Arecoline; Atropine; Drug Tolerance; Female; Hexobarbital; Humans; Mice; Morphine; Parasympatholytics; Pentylenetetrazole; Reserpine; Sleep; Substance Withdrawal Syndrome; Time Factors | 1975 |
Influence of disorders of adrenal function of activity and pharmacokinetics of some neurotropic drugs. I. Influence of adrenalectomy on potency and pharmacokinetics of drugs.
Topics: Adrenal Glands; Adrenalectomy; Animals; Biotransformation; Hexobarbital; Kinetics; Morphine; Rats; Salicylamides; Sleep; Time Factors | 1975 |
Modification of the analgesic effect and the effect on body temperature of morphine and fentanyl, included in liposomal suspensions.
Topics: Analgesics; Animals; Body Temperature; Fentanyl; Hexobarbital; Injections, Intraperitoneal; Liposomes; Male; Morphine; Pain; Rabbits; Rats; Rats, Inbred Strains; Sensory Thresholds; Suspensions | 1986 |
On the mechanisms of glutathione depletion in hepatocytes exposed to morphine and ethylmorphine.
Topics: Animals; Carmustine; Ethylmorphine; Glutathione; Glutathione Reductase; Hexobarbital; Hydrogen Peroxide; Liver; Male; Morphine; Morphine Derivatives; NADP; Rats; Rats, Inbred Strains | 1986 |
[General pharmacologic studies on the analgesic flupirtine].
Topics: Aminopyridines; Amphetamine; Analgesics; Animals; Anticonvulsants; Catalepsy; Central Nervous System; Diuresis; Dogs; Drug Interactions; Female; Hemodynamics; Hexobarbital; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Morphine; Motor Activity; Muscle Tonus; Oxotremorine; Parasympatholytics; Rats; Respiration | 1985 |
[Effect of various drugs on NMRI mice damaged by radiation and combined noxas].
Topics: Animals; Barbiturates; Blood Circulation; Drug Tolerance; Hexobarbital; Hydromorphone; Hypoxia; Lethal Dose 50; Mice; Mice, Inbred Strains; Morphine; Radiation Injuries, Experimental; Respiratory Paralysis; Wounds and Injuries | 1972 |
Evidence for an inhibitory product-cytochrome P-450 complex generated during benzphetamine metabolism by liver microsomes.
Topics: Aerobiosis; Animals; Appetite Depressants; Benzphetamine; Binding Sites; Cytochrome P-450 Enzyme System; Ethanol; Hexobarbital; Kinetics; Male; Microsomes, Liver; Morphine; NADP; Oxidoreductases, N-Demethylating; Phenethylamines; Protein Binding; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
[The effect of the type of premedication on the cardiovascular effects of inolin].
Topics: Adrenergic beta-Agonists; Anesthesia, General; Animals; Atropine; Blood Flow Velocity; Blood Pressure; Cardiovascular System; Chlorpromazine; Dogs; Drug Interactions; Hexobarbital; Isoquinolines; Morphine; Preanesthetic Medication; Pulmonary Circulation; Reaction Time; Regional Blood Flow; Thiopental; Vena Cava, Inferior; Venous Pressure | 1974 |
Varying effect of phenobarbital on hepatic drug metabolism in rats of different ages.
Topics: Age Factors; Animals; Animals, Newborn; Benzopyrenes; Enzyme Induction; Female; Fetus; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphine; Organ Size; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1974 |
Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aminopyrine; Aniline Compounds; Animals; Castration; Diabetes Mellitus, Experimental; Epinephrine; Female; Formaldehyde; Hexobarbital; Hypoxia; In Vitro Techniques; Liver; Male; Microsomes; Mixed Function Oxygenases; Morphine; Rats; Sex; Thyroxine; Zoxazolamine | 1965 |
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine | 1966 |
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Cortisone; Cytochrome c Group; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Female; Guinea Pigs; Hexobarbital; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Oxidoreductases; Pentylenetetrazole; Pharmaceutical Preparations; Phenobarbital; Rats; Research; Sleep; Spironolactone | 1972 |
Concomitant association between high plasma levels of growth hormone and low hepatic mixed-function oxidase activity in the young rat.
Topics: Age Factors; Aminopyrine; Aniline Compounds; Animals; Animals, Newborn; Body Weight; Cytochrome c Group; Cytochrome P-450 Enzyme System; Electron Transport; Female; Growth Hormone; Hexobarbital; Kinetics; Liver; Microsomes, Liver; Morphine; Oxidoreductases; Pharmaceutical Preparations; Pregnancy; Radioimmunoassay; Rats | 1974 |
Effects of hexobarbitone, ether, morphine, and urethane upon the acute toxicity of propranolol and D-(--)-INPEA.
Topics: Amino Alcohols; Animals; Atropine; Bradycardia; Central Nervous System; Drug Synergism; Ethers; Heart Arrest; Heart Rate; Hexobarbital; Lidocaine; Male; Mice; Morphine; Nitrobenzenes; Propranolol; Quinidine; Seizures; Sleep; Urethane | 1966 |
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; Kinetics; Liver; Male; Microsomes; Morphine; NADP; Niacinamide; Oxidation-Reduction; Pigments, Biological; Proadifen; Rats; Sex Factors; Spectrophotometry; Transferases | 1968 |
Taloximine, a new respiratory stimulant with brochodilator properties.
Topics: Anaphylaxis; Animals; Bronchi; Bronchodilator Agents; Cats; Dogs; Guinea Pigs; Heterocyclic Compounds; Hexobarbital; Histamine; Histamine H1 Antagonists; Humans; Mice; Morphine; Pentobarbital; Rabbits; Respiration; Stimulation, Chemical | 1969 |
Pharmacological properties of AF 1161, a new psychotropic drug.
Topics: Amphetamine; Animals; Avoidance Learning; Cats; Chlordiazepoxide; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Dogs; Electroencephalography; Female; Guinea Pigs; Hexobarbital; Histamine H1 Antagonists; Male; Mice; Morphine; Motor Activity; Pentobarbital; Piperazines; Psychopharmacology; Pyridines; Rabbits; Rats; Reflex; Serotonin Antagonists; Sleep; Triazoles | 1968 |
Species difference in the inhibition of drug metabolism by liver microsomes by different inhibitors.
Topics: Aminopyrine; Aniline Compounds; Animals; Cocaine; Depression, Chemical; Drug Antagonism; Ethylamines; Hexobarbital; Histamine H1 Antagonists; Kinetics; Male; Meperidine; Mice; Microsomes, Liver; Morphine; Nitrophenols; Oxidation-Reduction; Pentobarbital; Pharmaceutical Preparations; Phenacetin; Phenylhydrazines; Piperazines; Proadifen; Rabbits; Rats; Species Specificity; Zoxazolamine | 1969 |
Effects of metyrapone on liver microsomal drug oxidations.
Topics: Acetanilides; Aminopyrine; Animals; Depression, Chemical; Hexobarbital; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Morphine; NADP; Phenobarbital; Rats; Sleep; Stimulation, Chemical; Trichloroethylene; Tyramine | 1969 |
Effects of morphine treatment and starvation on the substrate interaction with P-450 in the oxidation of drugs by liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Blood Proteins; Castration; Chemical Phenomena; Chemistry; Depression, Chemical; Electron Transport; Female; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methyltestosterone; Microsomes, Liver; Morphine; NADP; Oxidation-Reduction; Oxidoreductases; Pigments, Biological; Rats; Spectrophotometry; Starvation; Stimulation, Chemical; Testosterone; Zoxazolamine | 1970 |
Induction of hepatic drug metabolism in rats by methylchloroform inhalation.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine; Animals; Chloroform; Cycloheximide; Cytochromes; Dactinomycin; Enzyme Induction; Hexobarbital; In Vitro Techniques; Liver; Male; Meprobamate; Microsomes, Liver; Morphine; NADP; Protein Binding; Rats; Reflex; Zoxazolamine | 1970 |
An approach measurement of the stoichiometric relationship between hepatic microsomal drug metabolism and the oxidation of reduced nicotinamide adenine dinucleotide phosphate.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Benzyl Compounds; Chlorine; Dealkylation; Ethylamines; Hexobarbital; Imipramine; Male; Methylamines; Microsomes, Liver; Morphine; NADP; Oxidation-Reduction; Pharmaceutical Preparations; Rats | 1972 |
Age-related responsiveness of the rat to drugs affecting the central nervous system.
Topics: Age Factors; Analgesia; Animals; Body Temperature; Brain; Chlorpromazine; Dextroamphetamine; Electroencephalography; Hexobarbital; Male; Morphine; Motor Activity; Rats | 1974 |
Monoamine oxidase-inhibiting activity of mangiferin isolated from Canscora decussata.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Dihydroxyphenylalanine; Drug Synergism; Hexobarbital; Ketones; Mice; Monoamine Oxidase Inhibitors; Morphine; Plants, Medicinal; Rats; Reserpine; Xanthenes | 1972 |
Polychlorinated biphenyls: comparative effects of high and low chlorine containing Aroclors on hepatic mixed function oxidase.
Topics: Aniline Compounds; Animals; Biphenyl Compounds; Cytochromes; Drug Interactions; Enzyme Induction; Hexobarbital; Injections, Intraperitoneal; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphine; Oxidoreductases; Polychlorinated Biphenyls; Rats; Spectrum Analysis; Stimulation, Chemical; Structure-Activity Relationship; Zoxazolamine | 1972 |
Interactions of the hexobarbital enantiomers with rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; Hemeproteins; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methyltransferases; Microsomes, Liver; Morphinans; Morphine; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1973 |
Growth hormone modulation of liver drug metabolic enzyme activity in the rat. II. Specificity of the hormone effect.
Topics: Albumins; Amino Acids; Aniline Compounds; Animals; Benzoates; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Globulins; Growth Hormone; Hexobarbital; Liver; Male; Microsomes, Liver; Morphine; Nitrobenzenes; Placental Lactogen; Prolactin; Rats; Swine | 1973 |
[Effect of anesthesia on the cardio-pulmonary reflexes in acute myocardial ischemia].
Topics: Acute Disease; Anesthesia, General; Animals; Dogs; Ethyl Ethers; Heart; Hexobarbital; Lung; Morphine; Myocardial Infarction; Reflex; Respiration; Vagus Nerve | 1973 |
Influence of clofibrate (ethyl-4-chlorophenoxyisobutyrate) on hepatic drug metabolism in male rats.
Topics: Age Factors; Aminopyrine; Aniline Compounds; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Glucosephosphate Dehydrogenase; Hexobarbital; Hydroxylation; Liver; Male; Microsomes, Liver; Morphine; Pentobarbital; Proteins; Rats; Sleep; Zoxazolamine | 1974 |
Thiazine dye antagonism of opioid lethality in mice.
Topics: Animals; Codeine; Dextropropoxyphene; Drug Synergism; Hexobarbital; Lethal Dose 50; Levorphanol; Male; Meperidine; Methadone; Methylene Blue; Mice; Morphinans; Morphine; Sleep; Thiazines; Time Factors; Tolonium Chloride | 1974 |
Letter: Chemical constituents of gentianaceae. XI. Antipsychotic activity of gentianine.
Topics: Alkaloids; Amphetamine; Animals; Anticonvulsants; Blepharoptosis; Drug Synergism; Hexobarbital; Humans; Hypnotics and Sedatives; Lethal Dose 50; Lysergic Acid Diethylamide; Mice; Morphine; Motor Activity; Plants, Medicinal; Rats; Stereotyped Behavior; Terpenes | 1974 |
Pharmacological studies on 2-methyl-3(2'-methyl-4'-chlorophenyl)-5-chloro-4[H)-quinazolinone (SL-164).
Topics: Aggression; Analgesics; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Blood Pressure; Cats; Chlordiazepoxide; Chlorpromazine; Drug Synergism; Electroencephalography; Haplorhini; Heart; Hexobarbital; Humans; Hypnotics and Sedatives; In Vitro Techniques; Male; Meprobamate; Methaqualone; Mice; Morphine; Muscle Relaxants, Central; Muscle, Smooth; Pentylenetetrazole; Quinazolines; Rabbits; Rats; Respiration; Strychnine; Tranquilizing Agents | 1969 |
Pharmacological significances of peptidase and proteinase in the brain. 4. Effect of bradykinin on the central nervous system and role of the enzyme inactivating bradykinin in mouse brain.
Topics: Aminophylline; Animals; Bradykinin; Brain; Central Nervous System; Edetic Acid; Endopeptidases; Glutathione; Hexobarbital; Injections; Injections, Intravenous; Kinins; Male; Mice; Morphine; Motor Activity; Sleep | 1970 |
Pharmacological studies on new potent central depressants, 8-chloro-6-phenyl-4H-s-triazolo [4,3a][1,4] benzodiazepine (D-40tA) and its 1-methyl analogue (D-65MT).
Topics: Administration, Oral; Aggression; Animals; Anticonvulsants; Antiemetics; Apomorphine; Avoidance Learning; Azepines; Behavior, Animal; Benzazepines; Cats; Central Nervous System; Chlordiazepoxide; Chlorprothixene; Diazepam; Discrimination Learning; Dogs; Drug Synergism; Female; Haplorhini; Hexobarbital; Humans; Injections, Intraperitoneal; Lethal Dose 50; Male; Mescaline; Methamphetamine; Mice; Morphine; Motor Activity; Muscle Relaxants, Central; Reserpine; Sleep; Tetrabenazine; Triazoles | 1971 |
[Comparative neurotropic activity of gamma-aminobutyric acid and its cetylic ester].
Topics: Aminobutyrates; Analgesics; Animals; Barbiturates; Cats; Cerebral Cortex; Drug Synergism; Hexobarbital; Hypoxia; Lethal Dose 50; Mice; Morphine; Piperidines; Rabbits; Rats; Seizures; Thiopental; Thiosemicarbazones; Visual Cortex | 1972 |
[Pharmacological studies of a new minor tranquilizer, dipotassium chlorazepate (7-chloro-1,3-dihydro-2-oxo-5-phenyl-1H-1, 4-benzodiazepine 3-carboxylic acid monopotassium salt monopotassium hydroxide). 1. Central action].
Topics: Animals; Anticonvulsants; Apomorphine; Bemegride; Benzazepines; Central Nervous System; Cerebral Cortex; Diazepam; Dogs; Electroencephalography; Evoked Potentials; Hexobarbital; Hypothalamus; Limbic System; Male; Mice; Morphine; Nicotine; Pentylenetetrazole; Rats; Strychnine; Tranquilizing Agents; Tremorine | 1972 |
[Effects of Natulan (procarbazine hydrochloride) on the central nervous system].
Topics: Analgesics; Animals; Behavior, Animal; Benzoates; Catalepsy; Central Nervous System; Chlorpromazine; Depression, Chemical; Electric Stimulation; Electroencephalography; Hexobarbital; Humans; Male; Mice; Morphine; Movement; Muscle Relaxants, Central; Pentylenetetrazole; Procarbazine; Rabbits; Rats; Reserpine; Sleep; Spasm | 1971 |
Species differences in the effect of morphine administration or adrenalectomy on the substrate interactions with cytochrome P-450 and drug oxidations by liver microsomes.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aminopyrine; Androgens; Aniline Compounds; Animals; Cytochromes; Dealkylation; Depression, Chemical; Female; Hexobarbital; Male; Methylation; Mice; Microsomes, Liver; Morphine; Oxidation-Reduction; Protein Binding; Proteins; Rabbits; Rats; Sex Factors; Species Specificity; Spectrophotometry | 1971 |
[Influence of various choleretics on biotransformation and biliary elimination of low molecular substances].
Topics: Aminopyrine; Animals; Bile; Biotransformation; Cholagogues and Choleretics; Codeine; Dehydrocholic Acid; Female; Hexobarbital; Liver; Male; Mice; Morphine; Phenols; Procaine; Rats; Salicylamides; Salicylates; Thiocyanates | 1971 |
Substrate interaction with P-450 in the hydroxylation of drugs under abnormal physiological states.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine; Androgens; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Female; Hexobarbital; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Morphine; Rats; Sex Factors; Spectrophotometry; Starvation; Thyroid Gland; Thyroidectomy; Thyroxine; Zoxazolamine | 1971 |
Effect of morphine administration on the activities of microsomal drug-metabolizing enzyme systems in liver of different species.
Topics: Aminopyrine; Aniline Compounds; Animals; Female; Guinea Pigs; Hexobarbital; Liver; Male; Mice; Microsomes; Mixed Function Oxygenases; Morphine; Rabbits; Rats | 1966 |
Failure of the vitamin E-deficient rat to show decreased liver codeine-O-demethylase activity.
Topics: Animals; Biotransformation; Body Weight; Codeine; Enzyme Induction; Hexobarbital; Liver; Male; Morphine; Organ Size; Rats; Spectrophotometry; Testis; Time Factors; Transferases; Vitamin E Deficiency | 1970 |
The effect of thyroid hormones on the action of some centrally acting drugs.
Topics: Analgesia; Animals; Caffeine; Castration; Dextroamphetamine; Drug Synergism; Ethinyl Estradiol; Hexobarbital; Male; Mice; Morphine; Motor Activity; Rats; Sex Factors; Sleep; Thyroidectomy; Thyroxine; Time Factors | 1970 |
Effects of various drugs on 3,4-dihydroxyphenylalanine (DL-DOPA)-induced excitation (agressive behavior) in mice.
Topics: Aggression; Animals; Antidepressive Agents; Autonomic Agents; Behavior, Animal; Bretylium Compounds; Chlordiazepoxide; Chlorpromazine; Diazepam; Dihydroxyphenylalanine; Drug Antagonism; Haloperidol; Hexobarbital; Humans; Imipramine; Iproniazid; Male; Mice; Morphine; Oxazepam; Reserpine; Tranquilizing Agents; Tranylcypromine; Trifluoperazine | 1970 |
[On pharmacology of a series of phenylalkylamines].
Topics: Aminopyrine; Analgesics; Animals; Appetite Depressants; Blood Pressure; Cardiovascular System; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Heart; Hexobarbital; In Vitro Techniques; Male; Methamphetamine; Mice; Morphine; Movement; Phenethylamines; Propylamines; Rabbits; Rats | 1967 |
Stress-induced alterations in microsomal drug metabolism in the adrenalectomized rat.
Topics: Adrenalectomy; Aniline Compounds; Animals; Cold Temperature; Enzyme Induction; Hexobarbital; Hydrocortisone; In Vitro Techniques; Liver; Male; Microsomes; Morphine; Organ Size; Phenobarbital; Rats; Steroids; Stress, Physiological; Thymus Gland | 1968 |
Inhibition of drug metabolism. V. Inhibition of drug metabolism by steroids.
Topics: Androsterone; Animals; Chlorpromazine; Cholesterol; Estradiol; Hexobarbital; Hydrocortisone; In Vitro Techniques; Liver; Male; Microsomes; Morphine; Progesterone; Rats; Steroids; Testosterone | 1968 |
Inhibition of drug metabolism. VI. Inhibition of hexobarbital metabolism in the isolated perfused liver of the rat.
Topics: Animals; Chlorpromazine; Codeine; Hexobarbital; In Vitro Techniques; Liver; Male; Morphine; Narcotics; Proadifen; Rats | 1968 |
The hypnotic properties of 8-ethylthio-6-thiotheophylline sodium.
Topics: Amphetamine; Animals; Caffeine; Chloral Hydrate; Chlorpromazine; Dogs; Drug Synergism; Hexobarbital; Hypnotics and Sedatives; Male; Meprobamate; Methylphenidate; Mice; Morphine; Nalorphine; Nikethamide; Pentobarbital; Pentylenetetrazole; Phenobarbital; Rabbits; Rats; Reserpine; Sleep; Theophylline; Thiopental | 1968 |
Studies on hepatic microsomal N- and O-dealkylation of morphine analogues.
Topics: Animals; Carbon Monoxide; Cytochromes; Fasting; Hexobarbital; Hot Temperature; Kinetics; Light; Liver; Male; Microsomes; Morphine; Phenobarbital; Rats | 1968 |
Inhibition of microsomal drug metabolism by methylenedioxybenzenes.
Topics: Aniline Compounds; Animals; Benzene Derivatives; Depression, Chemical; Dioxoles; Drug Synergism; Enzyme Induction; Glucosephosphate Dehydrogenase; Hexobarbital; Insecticides; Isocitrate Dehydrogenase; Liver; Male; Mice; Microsomes; Morphine; Proadifen; Rats; Sleep; Time Factors | 1968 |
[Pharmacologic study of certain sulfhydrazide and diacylhydrazine derivatives].
Topics: Animals; Barbiturates; Dihydroxyphenylalanine; Drug Antagonism; Drug Synergism; Hexobarbital; Hydrazines; Mice; Mitochondria, Liver; Monoamine Oxidase; Morphine; Nervous System; Nialamide; Reserpine; Seizures; Sulfones; Tyramine | 1968 |
The influence of age, sex and drug treatment on microsomal drug metabolism in four rat strains.
Topics: Age Factors; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphine; Phenobarbital; Proteins; Rabbits; Rats; Sex Factors; Species Specificity | 1969 |
[Modification of central mechanisms of action by anticholinergics].
Topics: Aggression; Amphetamine; Animals; Apomorphine; Atropine; Biperiden; Bridged-Ring Compounds; Central Nervous System; Chlorpromazine; Depression, Chemical; Drug Synergism; Esters; Female; Hexobarbital; Humans; Imipramine; Male; Mice; Morphine; Nicotine; Parasympatholytics; Pentylenetetrazole; Perphenazine; Rats; Stimulation, Chemical; Strychnine; Tremorine | 1969 |
Inhibition of drug metabolism. IV. Induction of drug metabolism by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and 2,4-dichloro-6-phenylphenoxyethylamine HBr (Lilly 18947) and the effect of induction on the inhibitory properties of SKF 525-A
Topics: Animals; Antimetabolites; Enzymes; Hexobarbital; Male; Microsomes; Morphine; Phenobarbital; Proadifen; Proteins; Rats | 1966 |
1,4,5,6-tetrahydro-as-triazines. II. Condensation of beta-aminoalkylhydrazines with iminoesters and orthoesters.
Topics: Amphetamine; Animals; Chemistry, Organic; Drug Synergism; Electric Stimulation; Electrophysiology; Hexobarbital; Hydrazines; Male; Mice; Morphine; Movement; Organic Chemistry Phenomena; Pain; Sleep; Triazines | 1967 |
[Studies on the physical dependence liability to guanabenz].
Topics: Analgesics; Animals; Antihypertensive Agents; Barbital; Body Weight; Drug Synergism; Guanabenz; Guanidines; Hexobarbital; Humans; Male; Mice; Morphine; Rats; Rats, Inbred Strains; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders | 1982 |
Antinociceptive effects of Randia siamensis extract and its constituent, pseudoginsenoside-RP1 in experimental animals.
Topics: Analgesics; Animals; Aspirin; Hexobarbital; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Pain Measurement; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Saponins; Sleep | 1994 |
[The effect of various pharmacological agents (amphetamine, cocaine, caffeine, hexobarbital, meprobamate, morphine, dextromoramide, 1-methadone, pethidine and CT 3570) on the time of exhaustion and behavior of animals swimming at 20 degrees C].
Topics: Amphetamine; Amphetamines; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Behavior; Caffeine; Central Nervous System Stimulants; Cocaine; Dextromoramide; Hexobarbital; Hypnotics and Sedatives; Meperidine; Meprobamate; Methadone; Morphine; Physical Exertion; Swimming; Tomography, X-Ray Computed | 1960 |
[Deviations in the pharmacodynamic action of various drugs by hypo- and hyperthermia. 2].
Topics: Acetylcholine; Aminobutyrates; Amphetamine; Amphetamines; Atropine; Chlordiazepoxide; Chlorpromazine; Cocaine; Convulsive Therapy; Electroconvulsive Therapy; Fever; Hexobarbital; Histamine; Hypothermia; Hypothermia, Induced; Lidocaine; Lobeline; Morphine; Papaverine; Phenobarbital; Promethazine; Thiopental | 1962 |
[Effect of narcotics, analeptics, secale preparations and phenothiazine derivatives on the vagal respiratory and circulatory reflexes in the rat and guinea pig].
Topics: Animals; Bemegride; Blood Circulation; Central Nervous System Stimulants; Chloralose; Chlorpromazine; Ergot Alkaloids; Guinea Pigs; Hexobarbital; Morphine; Narcotics; Pentobarbital; Pentylenetetrazole; Promazine; Promethazine; Rats; Reflex; Respiration; Secale; Thiopental; Vagus Nerve | 1962 |
[On cerebral polysynaptic reflexes in dogs and their modification by drugs].
Topics: Aminopyrine; Animals; Brain; Carisoprodol; Chlorpromazine; Dogs; Glutethimide; Hexobarbital; Hypnotics and Sedatives; Mephenesin; Morphine; Muscle Relaxants, Central; Reserpine; Tranquilizing Agents; Zoxazolamine | 1962 |
STRESS MODIFICATION OF DRUG RESPONSE.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Drug Tolerance; Hexobarbital; Meprobamate; Morphine; Pentobarbital; Pituitary Gland; Rats; Research; Stress, Physiological | 1963 |
BEHAVIOURAL AND PHARMACOLOGICAL STUDIES OF A TRANQUILISING FRACTION FROM THE OIL OF CELASTRUS PANICULATUS (MALKANGUNI OIL).
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Blood Pressure Determination; Body Temperature; Cats; Celastrus; Diuresis; Dogs; Haplorhini; Hexobarbital; Hypnotics and Sedatives; Mice; Morphine; Nervous System; Oils; Pentylenetetrazole; Pharmacology; Plants, Medicinal; Research; Reserpine; Toxicology; Tranquilizing Agents | 1963 |
CONDITIONED SUPPRESSION IN RATS AND THE EFFECT OF PHARMACOLOGICAL AGENTS THEREON.
Topics: Amobarbital; Amphetamine; Amphetamines; Avoidance Learning; Barbiturates; Carisoprodol; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Conditioning, Psychological; Ethanol; Hexobarbital; Hypnotics and Sedatives; Meprobamate; Morphine; Phenobarbital; Rats; Research | 1963 |
HYPERMOTILITY EVOKED BY LESIONS OF THE SEPTUM AND ANTERIOR HYPOTHALAMUS.
Topics: Aminopyrine; Amygdala; Atropine; Body Temperature; Caudate Nucleus; Cerebral Ventricles; Chlorpromazine; Electrocoagulation; Ephedrine; Hexobarbital; Hippocampus; Hypothalamus; Hypothalamus, Anterior; Imipramine; Iproniazid; Metabolism; Morphine; Movement Disorders; Physostigmine; Rats; Research; Reserpine; Scopolamine | 1963 |
ANTAGONISM OF MORPHINE AND OF RESERPINE BY LEVOROTATORY AND DEXTROROTATORY ISOMERS OF 2,2-DIPHENYL-4-(2-PIPERIDYL)-1,3-DIOXOLANE HCL.
Topics: Amphetamine; Amphetamines; Biphenyl Compounds; Chemical Phenomena; Chemistry; Dioxolanes; Heterocyclic Compounds; Hexobarbital; Hot Temperature; Hyperesthesia; Mice; Morphine; Pharmacology; Piperidines; Quinones; Reaction Time; Research; Reserpine; Sleep | 1963 |
MORPHINE INHIBITION OF DRUG METABOLISM IN THE RAT.
Topics: Adrenocorticotropic Hormone; Antimetabolites; Barbiturates; Hexobarbital; Meprobamate; Metabolism; Morphine; Pharmacology; Rats; Research | 1964 |
INVESTIGATION OF 3-(10,11-DIHYDRO-5H-DIBENZO (A,D) CYCLOHEPTEN-5-YLOXY) TROPANE CITRATE (DIBENZHEPTROPINE CITRATE, BRONTINE). I. PHARMACOLOGICAL PROPERTIES. II. TOXICOLOGICAL PROPERTIES.
Topics: Acetylcholine; Albumins; Animals; Asthma; Atropine; Bronchi; Citric Acid; Cyproheptadine; Diphenhydramine; Dogs; Edema; Fever; Gastric Juice; Guinea Pigs; Heterocyclic Compounds; Hexobarbital; Histamine H1 Antagonists; Morphine; Muscle Relaxants, Central; Parasympatholytics; Pentylenetetrazole; Pharmacology; Pupil; Quaternary Ammonium Compounds; Rabbits; Rats; Research; Salivation; Serotonin; Toxicology; Tranquilizing Agents; Tropanes | 1964 |
[ADVANCES IN ANESTHESIOLOGY].
Topics: Adjuvants, Anesthesia; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anesthesia; Anesthesia, Conduction; Anesthesia, Endotracheal; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; Anesthesiology; Antipyretics; Atropine; Blood Circulation; Halothane; Hexobarbital; Humans; Morphine; Muscle Relaxants, Central; Procaine; Respiration; Resuscitation; Shock, Surgical; Sympatholytics | 1964 |
THE PLACE OF ACETYLSALICYLIC ACID IN PSYCHOPHARMACOLOGY. AN EXPERIMENTAL STUDY.
Topics: Amphetamine; Amphetamines; Animals; Aspirin; Body Temperature Regulation; Chlordiazepoxide; Chlorpromazine; Electrophysiology; Ether; Guinea Pigs; Hexobarbital; Meprobamate; Mice; Morphine; Nikethamide; Pain; Pentylenetetrazole; Pharmacology; Phenobarbital; Poisoning; Psychopharmacology; Rabbits; Research; Sensory Receptor Cells; Sleep; Strychnine; Thiopental | 1963 |
KINETICS OF DRUG METABOLISM BY HEPATIC MICROSOMES.
Topics: Acetanilides; Chlorpromazine; Hexobarbital; Kinetics; Liver; Metabolism; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Morphine; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylbutazone; Rats; Research; Zoxazolamine | 1964 |
INHIBITION OF HEXOBARBITAL METABOLISM BY ETHYLMORPHINE AND CODEINE IN THE INTACT RAT.
Topics: Acetanilides; Antimetabolites; Antitussive Agents; Blood; Codeine; Ethylmorphine; Hexobarbital; Meprobamate; Morphine; Pharmacology; Proadifen; Rats; Research | 1964 |
PHARMACOLOGICAL PROPERTIES OF MORPHINE-POTENTIATING SERUM OBTAINED FROM MORPHINE-TOLERANT DOGS AND MEN.
Topics: Analgesia; Animals; Blood; Dogs; Drug Tolerance; Hexobarbital; Mice; Morphine; Morphine Dependence; Pain; Pain Management; Pharmacology; Research | 1964 |
STUDY OF THE EFFECTS OF MORPHINE AND NALORPHINE.
Topics: Animals; Body Temperature Regulation; Chlordiazepoxide; Chlorpromazine; Electroshock; Ether; Guinea Pigs; Hexobarbital; Meprobamate; Morphine; Nalorphine; Nikethamide; Pharmacology; Phenobarbital; Research; Respiration; Seizures; Sleep; Thiopental | 1964 |
THE EFFECT OF CODEINE TOLERANCE ON HEPATIC MICROSOMAL DRUG METABOLISM IN THE RAT.
Topics: Aminopyrine; Aniline Compounds; Benzoates; Benzopyrenes; Chlorpromazine; Codeine; Drug Tolerance; Hexobarbital; Liver; Metabolism; Morphine; Rats; Research; Sulfonamides; Zoxazolamine | 1965 |
STRESS-DRUG INTERACTIONS: EVIDENCE FOR RAPID ENZYME INDUCTION.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Blood; Corticosterone; Dactinomycin; Drug Interactions; Enzyme Induction; Hexobarbital; Hypophysectomy; Liver; Meprobamate; Metabolism; Morphine; Pentobarbital; Pharmacology; Phenobarbital; Physiology; Rats; Research; Stress, Physiological | 1965 |