Compounds > hexobarbital

hexobarbital and mercaptopurine

hexobarbital has been researched along with mercaptopurine in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Beck, FJ; Whitehouse, MW1
Bresnick, E; Grogan, DE; Lane, M; Smith, FE; Stone, K1
KLINGER, W1

Other Studies

7 other study(ies) available for hexobarbital and mercaptopurine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Impaired drug metabolism in rats associated with acute inflammation: a possible assay for anti-injury agents.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 145, Issue:1

    Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Azathioprine; Biological Assay; Cyclophosphamide; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Freund's Adjuvant; Hexobarbital; Humans; Hydroxylation; Inflammation; Irritants; Male; Mercaptopurine; Microsomes, Liver; Rats; Rats, Inbred Lew; Sleep; Time Factors

1974
Interaction of flavins and chloramphenicol with microsomal enzyme systems.
    Biochemical pharmacology, 1972, Dec-01, Volume: 21, Issue:23

    Topics: Acetanilides; Aminopyrine; Animals; Anisoles; Chloramphenicol; Dealkylation; Drug Interactions; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Formaldehyde; Hexobarbital; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mercaptopurine; Mice; Microsomes, Liver; Nitro Compounds; Organ Size; Proteins; Sleep; Time Factors

1972
[STUDIES ON THE MECHANISM OF ENZYME INDUCTION IN RATS AND MICE. I. THE EFFECTS OF 6-MERCAPTOPURINE AND RIBOAZAURACIL ON THE INCREASE IN L-ASCORBIC ACID SECRETION AND THE REDUCTION OF HEXOBARBITAL SLEEPING TIME AFTER BARBITAL ADMINISTRATION].
    Acta biologica et medica Germanica, 1964, Volume: 13

    Topics: Animals; Antimetabolites; Ascorbic Acid; Barbital; Body Fluids; Enzyme Induction; Fluids and Secretions; Hexobarbital; Mercaptopurine; Mice; Nucleosides; Pharmacology; Rats; Research; Sleep; Uracil; Urine

1964