hexobarbital has been researched along with mephenytoin in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Latham, AN; Sweeney, GD | 1 |
| Adedoyin, A; Blair, IA; Prakash, C; Wilkinson, GR | 1 |
| Kato, R; Murayama, N; Yamazoe, Y; Yasumori, T | 1 |
| Brian, WR; Guengerich, FP; Lloyd, RS; Srivastava, PK; Umbenhauer, DR | 1 |
| Dubey, RK; Guengerich, FP; Knodell, RG; Wilkinson, GR | 1 |
| Adedoyin, A; Blair, IA; O'Shea, D; Prakash, C; Wilkinson, GR | 1 |
7 other study(ies) available for hexobarbital and mephenytoin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes.
Topics: Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Glucaric Acid; Hexobarbital; In Vitro Techniques; Kinetics; Male; Mephenytoin; Microsomes, Liver; Phenobarbital; Phenylbutyrates; Phenytoin; Rats; Receptors, Drug; Urea | 1976 |
Enantiospecific quantification of hexobarbital and its metabolites in biological fluids by gas chromatography/electron capture negative ion chemical ionization mass spectrometry.
Topics: Adult; Electrochemistry; Gas Chromatography-Mass Spectrometry; Hexobarbital; Humans; Male; Mephenytoin; Oxidation-Reduction; Stereoisomerism | 1991 |
Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2.
Topics: Cytochrome P-450 Enzyme System; Hexobarbital; Humans; Hydantoins; Hydroxylation; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Stereoisomerism | 1990 |
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
Topics: Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Electrophoresis; Gene Expression Regulation; Genetic Vectors; Hexobarbital; Humans; Liver; Mephenytoin; Mixed Function Oxygenases; Oxidation-Reduction; Plasmids; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Sulfaphenazole; Tolbutamide | 1989 |
Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.
Topics: Cytochrome P-450 Enzyme System; Hexobarbital; Humans; Hydantoins; Hydroxylation; In Vitro Techniques; Liver; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic | 1988 |
Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects.
Topics: Administration, Oral; Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Asian People; Barbiturates; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Female; Hexobarbital; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Stereoisomerism; Urine; White People | 1994 |