hexobarbital has been researched along with antipyrine in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (82.35) | 18.7374 |
| 1990's | 6 (11.76) | 18.2507 |
| 2000's | 3 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caron, G; Ermondi, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Conney, AH; Kapitulnik, J; Popper, PJ | 1 |
| Breimer, DD; Richter, E; Zilly, W | 1 |
| Buening, MK; Conney, AH; Fortner, JG; Kapitulnik, J; Poppers, PJ | 1 |
| Dreher, W; Freundt, KJ; Kuttner, P | 1 |
| O'Malley, K; Stevenson, IH; West, M | 1 |
| Becher, H; Klinger, W; Schnupp, P | 1 |
| Breimer, DD; Buchenau, D; Richter, E; Wernze, H; Zilly, W | 1 |
| Alvares, AP; Anderson, KE; Fischbein, A; Kappas, A; Sassa, S | 1 |
| Ben-Zvi, Z; Hreash, F; Kaplanski, J | 1 |
| Breimer, DD; Janssens, AR; Schellens, JH; van der Velde, EA; van der Wart, JH | 1 |
| Breimer, DD; Danhof, M; Schellens, JH; van der Velde, EA; van der Wart, JH | 1 |
| Hanano, M; Harashima, H; Iga, T; Sawada, Y; Sugiyama, Y | 1 |
| Bien, E; Gebert, I; Skorka, G | 1 |
| Conney, AH; Kappas, A | 1 |
| Blumberg, JB; Hayes, KC; Meydani, M | 1 |
| Alexanderson, B; Kolmodin-Hedman, B; Sjöqvist, F | 1 |
| Edds, GT; Himes, JA; Shetty, SN | 1 |
| den Tonkelaar, EM; van Esch, GJ | 1 |
| Estabrook, RW; Greim, H; Remmer, H; Schenkman, J | 1 |
| Noordhoek, J; Rümke, CL | 2 |
| Ghazal, A; Ghoneim, MT; Mahfouz, M; Makar, AB | 1 |
| Hospador, MA; Manthei, RW | 1 |
| Grosso, LS; Hospador, MA; Manthei, RW | 1 |
| Kanazawa, T; Miyao, K; Ogo, T; Sato, M; Shiojiri, H | 1 |
| McEwen, J; Stevenson, IH | 1 |
| O'Malley, K; Sawyer, PR; Stevenson, IH | 1 |
| Murai, S; Oizumi, Y; Ozawa, H; Seto, S | 1 |
| Kappas, A; Poland, A | 1 |
| LeValley, SE; Mitoma, C | 1 |
| Dreher, W; Freundt, KJ | 1 |
| Avnimelech, M; Jondorf, WR; Simon, DC | 1 |
| Ben Zvi, Z; Kaplanski, J | 1 |
| Biltz, H; Pentz, R; Siegers, CP | 1 |
| Borchert, HH; Pfeifer, S; Schuster, S | 1 |
| Breimer, DD; Joeres, RP; van der Graaff, M; Vermeulen, NP | 1 |
| Breimer, DD; Joeres, RP; van der Graaff, M; Vermeulen, NP; Vlietstra, T | 1 |
| Belpaire, FM; De Rick, A; Rosseel, MT | 1 |
| Masnyj, J; Shargel, L | 1 |
| Bien, E; Buntrock, P; Skorka, G | 1 |
| Bachmann, K; Valentovic, M | 1 |
| Epping, J; Fuchshofen-Röckel, M; Heusler, H; Richter, E; Zilly, W | 1 |
| Blouin, RA; Hill, DB; Israel, BC; McClain, CJ; Shedlofsky, SI | 1 |
| Breimer, DD; Groen, K; Jansen, EJ; van Bezooijen, CF | 1 |
| Breimer, DD; Groen, K | 1 |
| Blouin, RA; Israel, BC; McIntyre, W; Shedlofsky, SI | 1 |
| Blouin, RA; Israel, BC; Shedlofsky, SI; Tosheva, R | 1 |
| GORDH, T | 1 |
2 review(s) available for hexobarbital and antipyrine
| Article | Year |
|---|---|
Interindividual differences in the metabolism of xenobiotics.
Topics: Aflatoxin B1; Aflatoxins; Antipyrine; Benzopyrenes; Biotransformation; Carcinogens; Coumarins; Desipramine; Diet; Dihydroxydihydrobenzopyrenes; Hexobarbital; Humans; Liver; Microsomes, Liver; Pharmaceutical Preparations; Smoking; Steroids; Zoxazolamine | 1985 |
Drug metabolism.
Topics: Adult; Aged; Alcohol Oxidoreductases; Animals; Antipyrine; Dogs; Enzyme Induction; Enzyme Inhibitors; Enzymes; Female; Half-Life; Hexobarbital; Humans; Liver; Liver Diseases; Male; Mice; Middle Aged; Pharmaceutical Preparations; Phenacetin; Rabbits; Rats; Species Specificity | 1972 |
2 trial(s) available for hexobarbital and antipyrine
| Article | Year |
|---|---|
Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients.
Topics: Aged; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Hexobarbital; Humans; Interferon-alpha; Liver; Male; Middle Aged; Neoplasms; Theophylline | 1993 |
Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; C-Reactive Protein; Cytochrome P-450 Enzyme System; Female; Fever; Hexobarbital; Humans; Hypnotics and Sedatives; Interleukin-6; Lipopolysaccharides; Liver; Middle Aged; Nephelometry and Turbidimetry; Phosphodiesterase Inhibitors; Regression Analysis; Theophylline; Tumor Necrosis Factor-alpha | 1997 |
47 other study(ies) available for hexobarbital and antipyrine
| Article | Year |
|---|---|
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Comparative metabolism of benzo[a]pyrene and drugs in human liver.
Topics: Adolescent; Adult; Aged; Antipyrine; Benzopyrene Hydroxylase; Benzopyrenes; Coumarins; Female; Hexobarbital; Humans; In Vitro Techniques; Liver; Male; Middle Aged; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Zoxazolamine | 1977 |
Influence of rifampicin on drug metabolism: differences between hexobarbital and antipyrine.
Topics: Adult; Antipyrine; Galactose; Half-Life; Hexobarbital; Humans; Indocyanine Green; Male; Metabolic Clearance Rate; Rifampin | 1977 |
Activation of monooxygenases in human liver by 7,8-benzoflavone.
Topics: Adolescent; Adult; Antipyrine; Autopsy; Benzopyrenes; Biopsy; Coumarins; Dealkylation; Enzyme Activation; Female; Flavonoids; Hexobarbital; Humans; Hydroxylation; In Vitro Techniques; Liver; Male; Microsomes, Liver; Middle Aged; Oxygenases; Zoxazolamine | 1977 |
Specifity and sensitivity of the inhibition of drug metabolism following inhalation of carbon disulphide-air mixtures.
Topics: Acetanilides; Animals; Antipyrine; Carbon Disulfide; Female; Hexobarbital; Mice; Microsomes, Liver; Pharmaceutical Preparations; Procaine; Rats; Sleep; Sulfisomidine; Trichloroethylene | 1976 |
The effect of fenfluramine on disposition and rate of antipyrine elimination.
Topics: Adolescent; Adult; Animals; Antipyrine; Body Height; Body Weight; Female; Fenfluramine; Half-Life; Hexobarbital; Humans; Male; Metabolic Clearance Rate; Middle Aged; Obesity; Rats | 1975 |
Daily rhythmic variation in hepatic amidopyrine-N-demethylation, hexobarbital sleeping time and acetanilide and phenazone toxicity in rats of different age.
Topics: Acetanilides; Age Factors; Aminopyrine; Animals; Antipyrine; Biotransformation; Circadian Rhythm; Hexobarbital; Liver; Male; Rats; Sleep | 1975 |
[Influence of rifampicin on the metabolic clearance of galactose and antipyrine as compared with hexobarbital].
Topics: Adult; Antipyrine; Galactose; Hexobarbital; Humans; Liver; Metabolic Clearance Rate; Rifampin; Stimulation, Chemical | 1975 |
Lead intoxication: effects on cytochrome P-450-mediated hepatic oxidations.
Topics: Adult; Aniline Hydroxylase; Animals; Antipyrine; Body Weight; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Half-Life; Hexobarbital; Humans; Lead; Lead Poisoning; Liver; Male; Microsomes, Liver; Middle Aged; Occupational Diseases; Oxidation-Reduction; Rats; Sleep | 1976 |
Disposition of hexobarbitone and antipyrine in DOCA-hypertensive rats.
Topics: Animals; Antipyrine; Desoxycorticosterone; Hemodynamics; Hexobarbital; Hypertension; Liver; Male; Mixed Function Oxygenases; Organ Size; Rats; Regional Blood Flow; Sleep; Time Factors | 1991 |
Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a 'cocktail' approach.
Topics: Adult; Aged; Antipyrine; Female; Hexobarbital; Humans; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Theophylline | 1989 |
Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach.
Topics: Adult; Antipyrine; Contraceptives, Oral; Female; Hexobarbital; Humans; Male; Metabolic Clearance Rate; Oxidation-Reduction; Regression Analysis; Sex Factors; Smoking; Theophylline | 1988 |
Prediction of serum concentration time course of quinidine in human using a physiologically based pharmacokinetic model developed from the rat.
Topics: Animals; Antipyrine; Half-Life; Hexobarbital; Humans; Kidney; Kinetics; Liver; Metabolic Clearance Rate; Models, Biological; Phenytoin; Quinidine; Rats; Time Factors | 1986 |
Biphasic effect of pyrazolone derivatives on drug-metabolizing enzyme in rat liver.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Dealkylation; Female; Hexobarbital; Liver; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Dietary fat unsaturation enhances drug metabolism in cebus but not in squirrel monkeys.
Topics: Animals; Antipyrine; Cebus; Chromatography, High Pressure Liquid; Dietary Fats; Drug Interactions; Fats, Unsaturated; Female; Half-Life; Hexobarbital; Injections, Intravenous; Male; Pentobarbital; Saimiri; Sex Factors; Sleep; Species Specificity | 1985 |
Effect of exposure to lindane on drug metabolism: decreased hexobarbital sleeping-times and increased antipyrine disappearance rate in rats.
Topics: Animals; Antipyrine; Brain Chemistry; Female; Hexachlorocyclohexane; Hexobarbital; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Sleep | 1971 |
Enzyme induction in sheep: effects of phenobarbital on in vivo and in vitro drug metabolism.
Topics: Anesthesia; Aniline Compounds; Animals; Antipyrine; Cytochromes; Dicumarol; Enzyme Induction; Female; Formaldehyde; Half-Life; Hexobarbital; Metabolic Clearance Rate; Microsomes, Liver; Pentobarbital; Phenobarbital; Phenols; Proteins; Sheep; Sleep; Sulfobromophthalein; Time Factors | 1972 |
No-effect levels of organochlorine pesticides based on induction of microsomal liver enzymes in short-term toxicity experiments.
Topics: Aniline Compounds; Animals; Antipyrine; Chlordan; DDT; Dichlorodiphenyldichloroethane; Dieldrin; Dose-Response Relationship, Drug; Endosulfan; Enzyme Induction; Germ-Free Life; Heptachlor; Hexachlorocyclohexane; Hexobarbital; Insecticides; Male; Methoxychlor; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Nitriles; Oxidoreductases; Polychlorinated Biphenyls; Rats | 1974 |
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action.
Topics: Aniline Compounds; Animals; Antipyrine; Benzopyrenes; Cytochromes; Dicumarol; Electron Transport; Enzyme Induction; Hexobarbital; Kinetics; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Protein Binding; Prothrombin Time | 1968 |
[Sex-specific differences in drug degradation in mice].
Topics: Animals; Antipyrine; Biotransformation; Female; Hexobarbital; Male; Mice; Microsomes, Liver; Pyrazoles; Sex Factors; Testosterone | 1969 |
Effect of schistosomal infection and of schistosomicidal drugs on the drug metabolizing enzymes of mouse liver.
Topics: Aniline Compounds; Animals; Anthelmintics; Antimony; Antipyrine; Benzenesulfonates; Dealkylation; Hexobarbital; Hydroxylation; Liver; Lucanthone; Male; Mice; Microsomes, Liver; Niridazole; Oxidation-Reduction; Paraoxon; Pharmaceutical Preparations; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Tartrates | 1974 |
Influence of age and diet on the induction of hexobarbital-metabolizing enzymes in the mouse.
Topics: Age Factors; Animals; Animals, Newborn; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Diet; Enzyme Induction; Hexobarbital; Histamine H1 Antagonists; Liver; Male; Metronidazole; Mice; Microsomes; Oils; Phenobarbital; Piperazines; Sleep; Starvation; Zea mays | 1968 |
Influence of age and diet on the induction of microsomal enzymes in the mouse.
Topics: Aging; Animals; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Cytochromes; Dietary Proteins; Enzyme Induction; Hexobarbital; Male; Mice; Microsomes, Liver; Phenobarbital; Piperazines; Protein Binding; Proteins; Spectrophotometry; Stimulation, Chemical; Ultracentrifugation | 1971 |
Effect of consecutive dosing of thiamphenicol on its own serm concentration and liver drug metabolizing enzyme activities.
Topics: Animals; Antipyrine; Chloramphenicol; Cytochrome P-450 Enzyme System; Formaldehyde; Hexobarbital; Hydroxylation; Immune Sera; Liver; Male; Microsomes, Liver; Phenethylamines; Rabbits | 1972 |
Proceedings: Effect of tricyclic antidepressants on drug metabolism.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents; Antipyrine; Desipramine; Dibenzazepines; Female; Half-Life; Hexobarbital; Humans; Imipramine; Liver; Male; Nortriptyline; Rats | 1972 |
[Pharmacological studies of troponoids. I. Hypothermic, analgesic and anti-inflammatory actions of troponoids].
Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Antipyrine; Aspirin; Body Temperature; Capillary Permeability; Chlorpromazine; Cycloheptanes; Erythema; Hexobarbital; Ketones; Male; Mice; Motor Activity; Pentylenetetrazole; Rats; Salicylates; Sleep; Strychnine | 1971 |
The metabolism of aminopyrine in chick embryo hepatic cell culture: effects of competitive substrates and carbon monoxide.
Topics: Aminopyrine; Animals; Antipyrine; Carbon Monoxide; Cells, Cultured; Chick Embryo; Dealkylation; Fatty Acids; Hexobarbital; Intestinal Mucosa; Kidney; Kinetics; Liver; Oxygen Consumption; Piperonyl Butoxide; Proadifen; Testosterone | 1971 |
Sex differences in the rate of drug metabolism in mice.
Topics: Animals; Antipyrine; Castration; Cytochromes; Depression, Chemical; Female; Hexobarbital; Liver; Male; Methylation; Mice; Ovary; Sex Factors; Testis; Testosterone; Time Factors | 1969 |
Effect on newborn rats of perinatal exposure to phenobarbital.
Topics: Acetaminophen; Animals; Animals, Newborn; Antipyrine; Brain; Female; Hexobarbital; Microsomes, Liver; Nitrophenols; Phenobarbital; Pregnancy; Pyrazoles; Rats; Sleep; Spectrophotometry | 1970 |
Inhibition of drug metabolism by small concentrations of carbon disulfide.
Topics: Aminopyrine; Animals; Antipyrine; Carbon Disulfide; Depression, Chemical; Female; Hexobarbital; Liver; Procaine; Pyrazoles; Rats; Sleep | 1969 |
Further studies on the stimulation of L-(14C)-amino acid incorporation with cycloheximide.
Topics: Aminopyrine; Aniline Compounds; Animals; Antifungal Agents; Antipyrine; Body Weight; Carbon Isotopes; Cycloheximide; Female; Growth; Hexobarbital; In Vitro Techniques; Liver; Magnesium; Microsomes; Organ Size; Phenylalanine; Proadifen; Rats; RNA; RNA, Messenger; Sleep; Sulfonamides | 1966 |
Effects of chronic heat exposure on drug metabolism in the rat.
Topics: Animals; Antipyrine; Body Temperature; Half-Life; Hexobarbital; Hot Temperature; Kinetics; Male; Oxidation-Reduction; Pharmaceutical Preparations; Rats; Sleep; Time Factors | 1980 |
Effect of diethyldithiocarbamate on the metabolic elimination of hexobarbital, phenazone, tolbutamide and four halogenated hydrocarbons.
Topics: Animals; Antipyrine; Ditiocarb; Hexobarbital; Hydrocarbons, Halogenated; Kinetics; Male; Mice; Mixed Function Oxygenases; Thiocarbamates; Tolbutamide | 1981 |
[Metabolic interactions of propyphenazone].
Topics: Animals; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Hexobarbital; Liver; NADPH-Ferrihemoprotein Reductase; Organ Size; Proteins; Rats; Rats, Inbred Strains | 1983 |
Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt.
Topics: Animals; Antipyrine; Biotransformation; Half-Life; Hexobarbital; Kinetics; Liver; Male; Oxidation-Reduction; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains | 1984 |
Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Hexobarbital; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Enhanced plasma binding of propranolol and oxprenolol and induction of hexobarbital and antipyrine metabolism by rifampicin treatment in the dog.
Topics: Animals; Antipyrine; Blood Proteins; Dogs; Female; Half-Life; Hexobarbital; Male; Oxprenolol; Propranolol; Protein Binding; Rifampin | 1982 |
Effect of stannous fluoride and sodium fluoride on hepatic mixed-function oxidase activities in the rat.
Topics: Animals; Antipyrine; Fluorides; Hexobarbital; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Rats; Sleep; Sodium Fluoride; Tin Fluorides | 1981 |
[Hepatotoxicological studies of pyrazolone derivatives on rats. Part 2: The study of propyphenazone and phenazone (author's transl)].
Topics: Aminopyrine N-Demethylase; Animals; Antipyrine; Body Weight; Chemical and Drug Induced Liver Injury; Female; Hexobarbital; Organ Size; Rats; Sleep; Time Factors | 1981 |
Effects of urea on hexobarbital and antipyrine disposition in rats.
Topics: Animals; Antipyrine; Blood Urea Nitrogen; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Half-Life; Hexobarbital; In Vitro Techniques; Liver; Rats; Sleep; Urea; Uremia | 1980 |
[Drug metabolism in patients with liver disease (author's transl)].
Topics: Acute Disease; Adult; Antipyrine; Biological Availability; Biotransformation; Cholestasis; Female; Hepatitis; Hexobarbital; Humans; Lidocaine; Liver Cirrhosis; Liver Diseases; Male; Methohexital; Middle Aged | 1980 |
Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
Topics: Administration, Oral; Adult; Antipyrine; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Endotoxins; Hexobarbital; Humans; Interleukin-6; Lipopolysaccharides; Liver; Male; Metabolic Clearance Rate; Orosomucoid; Pharmacokinetics; Theophylline; Tumor Necrosis Factor-alpha | 1994 |
The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Longitudinal Studies; Male; Metabolic Clearance Rate; Phenobarbital; Rats; Rats, Inbred BN; Stereoisomerism | 1994 |
Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Half-Life; Hexobarbital; Humans; Molecular Probes; Rats; Substrate Specificity; Theophylline | 1996 |
[LOCAL COMPLICATIONS OF INTRAVENOUS ANESTHESIA].
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics; Antipyrine; Glycerol; Hexobarbital; Humans; Injections; Injections, Intra-Arterial; Injections, Intravenous; Necrosis; Thrombosis; Toxicology | 1964 |